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Newest in this topic

  1. Evidence that the perinatal maternal microbiome mediates metabolite signaling programs that drive sex-specific microglial metabolic alterations and Alzheimer’s disease susceptibility 2026-10-23
  2. Change in gut microbiome precedes symptomatic Alzheimer’s disease and is correlated with amyloid-beta accumulation in the brain 2026-10-19
  3. The microbial soy metabolite S-equol mitigates cadmium neurotoxicity in mice 2026-10-06

Studies

173 studies carry this tag.

Date range

1998 to 2026

Top journals

  • Journal of Alzheimer's disease : JAD 13
  • Scientific reports 8
  • Molecular neurobiology 5
  • bioRxiv 5
  • Aging 4

104 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. Dysbiosis and Alzheimer's disease: role of probiotics, prebiotics and synbiotics

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Naunyn-Schmiedeberg's archives of pharmacology 2023-06-07 Disease mechanisms

    Alzheimer's disease (AD) is a neurodegenerative disease characterized by dementia and the accumulation of amyloid beta in the brain.

  2. Emerging role of gut microbiota dysbiosis in neuroinflammation and neurodegeneration

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Frontiers in neurology 2023-05-15 Disease mechanisms

    Alzheimer's disease (AD), is a chronic age-related progressive neurodegenerative disorder, characterized by neuroinflammation and extracellular aggregation of Aβ peptide.

  3. Microbiota-gut-brain axis and related therapeutics in Alzheimer's disease: prospects for multitherapy and inflammation control

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Reviews in the neurosciences 2023-04-20 Disease mechanisms

    Alzheimer's disease (AD) is the most common type of dementia in the elderly and causes neurodegeneration, leading to memory loss, behavioral disorder, and psychiatric impairment.

  4. Probiotic intervention benefits multiple neural behaviors in older adults with mild cognitive impairment

    ✓ Peer-reviewed alzhub usefulness score 70 out of 100. Geriatric nursing (New York, N.Y.) 2023-03-28 Disease mechanisms

    Probiotic supplements were shown to improve cognitive function in Alzheimer's disease (AD) patients.

  5. Gut Microbiota, an Additional Hallmark of Human Aging and Neurodegeneration

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Neuroscience 2023-03-08 Disease mechanisms

    Gut microbiota represents a diverse and dynamic population of microorganisms harbouring the gastrointestinal tract, which influences host health and disease.

  6. ApoE isoform- and microbiota-dependent progression of neurodegeneration in a mouse model of tauopathy

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Science (New York, N.Y.) 2023-01-13 Disease mechanisms

    Tau-mediated neurodegeneration is a hallmark of Alzheimer's disease.

  7. ALZHEIMER'S DISEASE AND ITS RELATIONSHIP WITH THE MICROBIOTA-GUT-BRAIN AXIS

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Arquivos de gastroenterologia 2023 Disease mechanisms

    The composition of the gut microbiota influences the CNS, resulting in changes in host behavior and may be related to the development of neurodegenerative diseases.

  8. Gut-derived β-amyloid: Likely a centerpiece of the gut-brain axis contributing to Alzheimer's pathogenesis

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Gut microbes 2023 Disease mechanisms

    Peripheral β-amyloid (Aβ), including those contained in the gut, may contribute to the formation of Aβ plaques in the brain, and gut microbiota appears to exert an impact on Alzheimer's disease (AD) via the gut-brain axis, although detailed mechanisms are not clearly defined.

  9. Gut microbiome and human health: Exploring how the probiotic genus Lactobacillus modulate immune responses

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Frontiers in pharmacology 2022-10-24 Disease mechanisms

    The highest density of microbes resides in human gastrointestinal tract, known as "Gut microbiome".

  10. The emerging role of the microbiome in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. International review of neurobiology 2022-10-13 Disease mechanisms

    Alzheimer's disease (AD) is the most prevalent form of dementia and can be influenced by genetic and environmental factors.

  11. Diet, Gut Microbiome, and Cognitive Decline

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Current nutrition reports 2022-08-26 Disease mechanisms

    An epidemic of age-associated cognitive decline, most commonly ascribed to neurodegenerative conditions such as Alzheimer's and Parkinson's disease, is causing healthcare costs to soar and devastating caregivers.

  12. Microbiota-derived metabolite Indoles induced aryl hydrocarbon receptor activation and inhibited neuroinflammation in APP/PS1 mice

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Brain, behavior, and immunity 2022-08-10 Disease mechanisms

    Gut microbiota alterations might affect the development of Alzheimer's disease (AD) through microbiota-derived metabolites.

  13. Mechanisms of Short-Chain Fatty Acids Derived from Gut Microbiota in Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Aging and disease 2022-07-11 Disease mechanisms

    Short-chain fatty acids (SCFAs) are important metabolites derived from the gut microbiota through fermentation of dietary fiber.

  14. Microbiota-gut-brain axis in the Alzheimer's disease pathology - an overview

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Neuroscience research 2022-05-14 Disease mechanisms

    Alzheimer's disease (AD) and related dementias (ADRD) are still a serious global public health concern more than a century after the German neuropathologist and psychiatrist Dr. Aloysius Alzheimer described the first case.

  15. Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brain

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Microbiome 2022-04-29 Brain scans and imaging

    These findings demonstrate that the aging gut microbiota drives detrimental changes in the gut-brain and gut-retina axes suggesting that microbial modulation may be of therapeutic benefit in preventing inflammation-related tissue decline in later life.

  16. Metabolites of soil microorganisms modulate amyloid β production in Alzheimer's neurons

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Scientific reports 2022-03-02 Biomarkers

    Microbial flora is investigated to be related with neuropathological conditions in Alzheimer's disease (AD), and is attracting attention as a drug discovery resource.

  17. The Potential Role of Gut Microbiota in Alzheimer's Disease: From Diagnosis to Treatment

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Nutrients 2022-02-05 Disease mechanisms

    Gut microbiota is emerging as a key regulator of many disease conditions and its dysregulation is implicated in the pathogenesis of several gastrointestinal and extraintestinal disorders.

  18. Gut microbiota in patients with Alzheimer's disease spectrum: a systematic review and meta-analysis

    ✓ Peer-reviewed alzhub usefulness score 79 out of 100. Aging 2022-01-14 Disease mechanisms

    Patients with AD spectrum demonstrated altered GM abundance, which was differentially mediated by countries and clinical stages.

  19. Gut microbiota regulate Alzheimer's disease pathologies and cognitive disorders via PUFA-associated neuroinflammation

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Gut 2022-01-11 Disease mechanisms

    These findings support that a complex gut microbiome is required for behavioural defects, microglia activation and AD pathologies, the gut microbiome contributes to pathologies in an AD mouse model and that dysbiosis of the human microbiome might be a risk factor for AD.

  20. Diet Patterns, the Gut Microbiome, and Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Journal of Alzheimer's disease : JAD 2022 Disease mechanisms

    Given the complex bidirectional communication system that exists between the gut microbiome and the brain, there is growing interest in the gut microbiome as a novel and potentially modifiable risk factor for Alzheimer's disease (AD).

  21. Gut Microbiota as a Hidden Player in the Pathogenesis of Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Journal of Alzheimer's disease : JAD 2022 Disease mechanisms

    Alzheimer's disease (AD), the most common neurodegenerative disorder, is accompanied by cognitive impairment and shows representative pathological features, including senile plaques and neurofibrillary tangles in the brain.

  22. Periodontitis-related salivary microbiota aggravates Alzheimer's disease via gut-brain axis crosstalk

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Gut microbes 2022 Disease mechanisms

    The oral cavity is the initial chamber of digestive tract; the saliva swallowed daily contains an estimated 1.5 × 1012 oral bacteria.

  23. Relationship Between Plasma Neurofilament Light Chain, Gut Microbiota, and Dementia: A Cross-Sectional Study

    ✓ Peer-reviewed alzhub usefulness score 66 out of 100. Journal of Alzheimer's disease : JAD 2022 Biomarkers

    We analyzed 128 participants (women: 59%, mean age: 74 years).

  24. Relationship Between the Gut Microbiota and Alzheimer's Disease: A Systematic Review

    ✓ Peer-reviewed alzhub usefulness score 63 out of 100. Journal of Alzheimer's disease : JAD 2022 Disease mechanisms

    Eight observational studies were selected, carried out in humans and, therefore, suitable for inclusion in this review.

  25. The Gut Microbiome and Alzheimer's Disease: A Growing Relationship

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Current Alzheimer research 2022 Disease mechanisms

    Evidence that the gut microbiota plays a key role in the pathogenesis of Alzheimer's disease is already unravelling.

  26. Effects of gut microbiota and probiotics on Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Translational neuroscience 2021-12-27 Disease mechanisms

    Alzheimer's disease (AD) is a progressive neurodegenerative disease with high morbidity, disability, and fatality rate, significantly increasing the global burden of public health.

  27. Periodontal Disease: The Good, The Bad, and The Unknown

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Frontiers in cellular and infection microbiology 2021-12-07 Disease mechanisms

    Periodontal disease is classically characterized by progressive destruction of the soft and hard tissues of the periodontal complex, mediated by an interplay between dysbiotic microbial communities and aberrant immune responses within gingival and periodontal tissues.

  28. Extra-virgin olive oil and the gut-brain axis: influence on gut microbiota, mucosal immunity, and cardiometabolic and cognitive health

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Nutrition reviews 2021-11-10 Disease mechanisms

    Extra-virgin olive oil (EVOO), a popular functional food and major source of fat in the Mediterranean diet, possesses a variety of healthful components, including monounsaturated fatty acids and bioactive phenolic compounds that, individually and collectively, exert beneficial effects on cardiometabolic markers of health and act as neuroprotective agents through their anti-inflammatory and antioxidant activities.

  29. Oral frailty and neurodegeneration in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Neural regeneration research 2021-11 Clinical trials

    Frailty is a critical intermediate status of the aging process with a multidimensional and multisystem nature and at higher risk for adverse health-related outcomes, including falls, disability, hospitalizations, institutionalization, mortality, dementia, and Alzheimer's disease.

  30. Identification of Faecalibacterium prausnitzii strains for gut microbiome-based intervention in Alzheimer's-type dementia

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Cell reports. Medicine 2021-09-14 Disease mechanisms

    Evidence linking the gut-brain axis to Alzheimer's disease (AD) is accumulating, but the characteristics of causally important microbes are poorly understood.

  31. Transplantation of gut microbiota derived from Alzheimer's disease mouse model impairs memory function and neurogenesis in C57BL/6 mice

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Brain, behavior, and immunity 2021-09-06 Disease mechanisms

    Alzheimer's disease (AD) is a neurodegenerative disease that causes memory and cognitive decline.

  32. Nutrition, Gut Microbiota, and Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Frontiers in psychiatry 2021-08-05 Disease mechanisms

    Nutrition is known to play an important role in the pathogenesis of Alzheimer's disease.

  33. Fecal Microbiota Transplantation: A Microbiome Modulation Technique for Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Cureus 2021-07-20 Disease mechanisms

    Alzheimer's disease (AD) is the most common form of dementia and the fifth leading cause of death among the elderly.

  34. Western diet as a trigger of Alzheimer's disease: From metabolic syndrome and systemic inflammation to neuroinflammation and neurodegeneration

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Ageing research reviews 2021-06-30 Disease mechanisms

    An excess of saturated fatty acids and simple sugars in the diet is a known environmental risk factor of Alzheimer's disease (AD) but the holistic view of the interacting processes through which such diet may contribute to AD pathogenesis is missing.

  35. The Oral-Gut-Brain AXIS: The Influence of Microbes in Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Frontiers in cellular neuroscience 2021-04-14 Disease mechanisms

    Alzheimer's disease (AD) is one of the most frequently diagnosed neurodegenerative disorders worldwide and poses a major challenge for both affected individuals and their caregivers.

  36. Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. eLife 2021-04-13 Genetics

    Previous studies have identified a crucial role of the gut microbiome in modifying Alzheimer's disease (AD) progression.

  37. Periodontal dysbiosis associates with reduced CSF Aβ42 in cognitively normal elderly

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. Alzheimer's & dementia (Amsterdam, Netherlands) 2021-04-12 Tau biomarkers

    At genera and species levels, higher subgingival periodontal dysbiosis was associated with reduced CSF amyloid beta (Aβ)42 (P = 0.02 and 0.01) but not with P-tau.

  38. Mannan oligosaccharide attenuates cognitive and behavioral disorders in the 5xFAD Alzheimer's disease mouse model via regulating the gut microbiota-brain axis

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Brain, behavior, and immunity 2021-04-09 Disease mechanisms

    Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by cognitive deficits and psychiatric symptoms.

  39. Alterations in the Gut-Microbial-Inflammasome-Brain Axis in a Mouse Model of Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Cells 2021-04-01 Inflammation and the immune system

    Alzheimer's disease (AD), a progressive neurodegenerative disorder characterized by memory loss and cognitive decline, is a major cause of death and disability among the older population.

  40. The oralome and its dysbiosis: New insights into oral microbiome-host interactions

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Computational and structural biotechnology journal 2021-02-27 Disease mechanisms

    The oralome is the summary of the dynamic interactions orchestrated between the ecological community of oral microorganisms (comprised of up to approximately 1000 species of bacteria, fungi, viruses, archaea and protozoa - the oral microbiome) that live in the oral cavity and the host.

  41. Structural and Functional Dysbiosis of Fecal Microbiota in Chinese Patients With Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Frontiers in cell and developmental biology 2021-02-04 Disease mechanisms

    Increasing evidence suggests that gut dysbiosis plays vital roles in a variety of gut-brain disorders, such as Alzheimer's disease (AD).

  42. Gut Microbiome Features of Chinese Patients Newly Diagnosed with Alzheimer’s Disease or Mild Cognitive Impairment

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Journal of Alzheimer s Disease 2021-01-29 Disease mechanisms

    Although there was no difference in the microbial α-diversity among the three groups, patients with AD or MCI had increased β-diversity compared with healthy controls.

  43. Dysbiosis and Alzheimer's Disease: Cause or Treatment Opportunity?

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Cellular and molecular neurobiology 2021-01-05 Disease mechanisms

    Recent investigations have increased the interest on the connection between the microorganisms inhabiting the gut (gut microbiota) and human health.

  44. Probiotic Supplementation Improves Cognitive Function and Mood with Changes in Gut Microbiota in Community-Dwelling Older Adults: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial

    ✓ Peer-reviewed alzhub usefulness score 77 out of 100. The journals of gerontology. Series A, Biological sciences and medical sciences 2021-01-01 Clinical trials

    Probiotics have been proposed to ameliorate cognitive impairment and depressive disorder via the gut-brain axis in patients and experimental animal models.

  45. The impact of the microbiota-gut-brain axis on Alzheimer's disease pathophysiology

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Pharmacological research 2020-11-25 Disease mechanisms

    The gut microbiota is a complex ecosystem that comprises of more than 100 trillion symbiotic microbial cells.

  46. Metabolic Network Analysis Reveals Altered Bile Acid Synthesis and Metabolism in Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Cell reports. Medicine 2020-11-17 Disease mechanisms

    Increasing evidence suggests Alzheimer's disease (AD) pathophysiology is influenced by primary and secondary bile acids, the end product of cholesterol metabolism.

  47. Gut mycobiome and its interaction with diet, gut bacteria and alzheimer's disease markers in subjects with mild cognitive impairment: A pilot study

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. EBioMedicine 2020-08-30 Disease mechanisms

    Compared to CN counterparts, patients with MCI have higher proportion of families Sclerotiniaceae, Phaffomyceteceae, Trichocomaceae, Cystofilobasidiaceae, Togniniaceae and genera Botrytis, Kazachstania, Phaeoacremonium and Cladosporium and lower abundance of Meyerozyma.

  48. Gut Microbiota and Dysbiosis in Alzheimer's Disease: Implications for Pathogenesis and Treatment

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Molecular neurobiology 2020-08-23 Disease mechanisms

    Understanding how gut flora influences gut-brain communications has been the subject of significant research over the past decade.

  49. Gut dysbiosis contributes to amyloid pathology, associated with C/EBPβ/AEP signaling activation in Alzheimer's disease mouse model

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Science advances 2020-07-29 Disease mechanisms

    The gut-brain axis is bidirectional, and gut microbiota influence brain disorders including Alzheimer's disease (AD).

  50. Dysbiosis, gut barrier dysfunction and inflammation in dementia: a pilot study

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. BMC Geriatrics 2020-07-20 Disease mechanisms

    Dementia was associated with dysbiosis characterized by differences in beta diversity and changes in taxonomic composition.

From across this tag

8 of the 173 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 8. The same 8 appear here every time.

All topic tags with their study counts