Get help now — free helplines

You can call any of these for free. You do not need a diagnosis, an appointment, or a crisis to call — questions and plain exhaustion are reasons enough.

  • Alzheimer's Association 24/7 Helpline 800-272-3900 24 hours a day, 365 days a year Free, confidential support and information for people with dementia, caregivers, families and the public. Master's-level clinicians. Also Spanish.
  • 988 Suicide & Crisis Lifeline 988 24/7 Call or text 988, or chat at 988lifeline.org. For anyone in emotional distress or a mental-health crisis, including caregivers.
  • Alzheimer's Foundation of America (AFA) Helpline 866-232-8484 9:00 am - 9:00 pm ET, seven days a week Licensed social workers providing support, info and referrals. Also text message and web chat. Text: 646-586-5283

In a medical emergency, call 911. More numbers, and what each line does, on the help page.

Newest in this topic

  1. Interventions for Cognitive Impairment in Type 2 Diabetes Mellitus: An Umbrella Review of Pharmacological and Lifestyle Strategies, Mechanisms, and Clinical Implications 2026-10-26
  2. Visit-to-Visit Blood Pressure Variability, Glycemic Status and the Risk of Dementia, Stroke, and All-Cause Mortality: A UK Biobank Cohort Study 2026-10-13
  3. Plasma metabolomic profiling of frailty in older adults at risk of dementia 2026-10-08

Studies

304 studies carry this tag.

Date range

1984 to 2026

Top journals

  • Journal of Alzheimer's disease : JAD 21
  • medRxiv 16
  • Alzheimer's & dementia : the journal of the Alzheimer's Association 14
  • Neurology 10
  • Nutrients 10

164 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. Dementia risk and prevention by targeting modifiable vascular risk factors

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Journal of neurochemistry 2017-09-06 Prevention trials

    The incidence of dementia is expected to double in the next 20 years and will contribute to heavy social and economic burden.

  2. Association between chronic periodontitis and the risk of Alzheimer's disease: a retrospective, population-based, matched-cohort study

    ✓ Peer-reviewed alzhub usefulness score 72 out of 100. Alzheimer's research & therapy 2017-08-08 Costs and economics

    Our findings demonstrate that 10-year CP exposure was associated with a 1.707-fold increase in the risk of developing AD.

  3. Effects of metformin exposure on neurodegenerative diseases in elderly patients with type 2 diabetes mellitus

    ✓ Peer-reviewed alzhub usefulness score 69 out of 100. Progress in neuro-psychopharmacology & biological psychiatry 2017-06-03 Costs and economics

    Epidemiological evidence reveals that patients with type 2 diabetes mellitus (T2DM) have an increased risk of neurodegenerative diseases (NDs), including dementia and Parkinson's disease (PD).

  4. Dementia and osteoporosis in a geriatric population: Is there a common link?

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. World journal of orthopedics 2017-05-18 Prevention and risk

    Dementia and osteoporosis are multifaceted disease processes with similar epidemiology and a marked increase in prevalence in elderly populations.

  5. Evidence for benefit of statins to modify cognitive decline and risk in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 66 out of 100. Alzheimer's research & therapy 2017-02-17 Drug development

    These results indicate that the use of statins may benefit all AD patients with potentially greater therapeutic efficacy in those homozygous for ApoE4.

  6. Some observational studies raised concern that statins may cause memory impairment, leading to a US Food and Drug Administration warning.

  7. Sex and Race Differences in the Association Between Statin Use and the Incidence of Alzheimer Disease

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. JAMA neurology 2017-02-01 Drug development

    However, several drugs prescribed for other conditions have been associated with reducing its risk.

  8. Metabolic syndrome, hypertension, and nervous system injury: Epidemiological correlates

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Clinical and experimental hypertension (New York, N.Y. : 1993) 2017-01-10 Risk factors

    Metabolic syndrome (MetS) is a common and complex disorder combining hypertension, obesity, dyslipidemia, and insulin resistance.

  9. Association Between Androgen Deprivation Therapy and Risk of Dementia

    ✓ Peer-reviewed alzhub usefulness score 67 out of 100. JAMA oncology 2017-01-01 Digital health tools

    Androgen deprivation therapy in the treatment of prostate cancer may be associated with an increased risk of dementia.

  10. Effects of Regular and Long-Acting Insulin on Cognition and Alzheimer's Disease Biomarkers: A Pilot Clinical Trial

    ✓ Peer-reviewed alzhub usefulness score 78 out of 100. Journal of Alzheimer's disease : JAD 2017-01-01 Clinical trials

    Future research is warranted to examine the mechanistic basis of treatment differences, and to further assess the efficacy and safety of intranasal insulin.

  11. Insulin Resistance and Future Cognitive Performance and Cognitive Decline in Elderly Patients with Cardiovascular Disease

    ✓ Peer-reviewed alzhub usefulness score 67 out of 100. Journal of Alzheimer's disease : JAD 2017-01-01 Cognitive tests and assessment

    IR is related to subsequent poorer cognitive performance and greater cognitive decline among patients with cardiovascular disease with and without diabetes.

  12. Midlife Metabolic Profile and the Risk of Late-Life Cognitive Decline

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. Journal of Alzheimer's disease : JAD 2017 Risk factors

    Among metabolic syndrome components, the effects of higher plasma glucose levels on cognitive decline (CD) have been considered in few studies.

  13. Metabolic, inflammatory, and microvascular determinants of white matter disease and cognitive decline

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. American journal of neurodegenerative disease 2016-11-30 Risk factors

    White Matter Disease is increasingly being recognized as an important cause of cognitive decline and dementia.

  14. Interactions between inflammation, sex steroids, and Alzheimer's disease risk factors

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Frontiers in neuroendocrinology 2016-09-17 Risk factors

    Alzheimer's disease (AD) is an age-related neurodegenerative disorder for which there are no effective strategies to prevent or slow its progression.

  15. Predicting dementia in primary care patients with a cardiovascular health metric: a prospective population-based study

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. BMC neurology 2016-07-26 Digital health tools

    Due to complex relationships of body-mass index and blood pressure with dementia individual components cancelled each other out and rendered the sum-scores meaningless for the prediction of dementia.

  16. [Nutrition and cognitive impairment]

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Nutricion hospitalaria 2016-07-12 Prevention and risk

    Dementia, closely linked to environmental predisposing factors such as diet, is a public health problem of increasing magnitude: currently there are more than 35 million patients with Alzheimer´s disease, and is expected to exceed 135 million by 2050.

  17. Diabetes is associated with cerebrovascular but not Alzheimer's disease neuropathology

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2016-01-23 End-of-life care

    This study supports the conclusions that diabetes increases the risk of cerebrovascular but not Alzheimer's disease pathology, and at least some of diabetes' relationship to cognitive impairment may be modified by neuropathology.

  18. Blood metabolite markers of preclinical Alzheimer's disease in two longitudinally followed cohorts of older individuals

    ✓ Peer-reviewed alzhub usefulness score 67 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2016-01-21 Biomarkers

    We believe that ours is the largest blood biomarker study of preclinical AD to date.

  19. Metformin in Amnestic Mild Cognitive Impairment: Results of a Pilot Randomized Placebo Controlled Clinical Trial

    ✓ Peer-reviewed alzhub usefulness score 74 out of 100. Journal of Alzheimer's disease : JAD 2016-01-01 Drug development

    Diabetes and hyperinsulinemia may be risk factors for Alzheimer's disease (AD).

  20. Multi-Nutrient Dietary Intervention Approach to the Management of Alzheimer's Disease - A Mini-Review

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Current Alzheimer research 2016 Prevention and risk

    Alzheimer's disease (AD) is currently the most common incurable forms of dementia.

  21. Androgen Deprivation Therapy and Future Alzheimer's Disease Risk

    ✓ Peer-reviewed alzhub usefulness score 67 out of 100. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2015-12-07 Digital health tools

    Our results support an association between the use of ADT in the treatment of prostate cancer and an increased risk of Alzheimer's disease in a general population cohort.

  22. Is it always Alzheimer's? Let's talk to our patients about "cardiocerebrovascular" prevention

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Aging clinical and experimental research 2015-11-11 Prevention and risk

    Unlike Alzheimer's, vascular dementia can, in part, be prevented.

  23. Meta-analysis of modifiable risk factors for Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 64 out of 100. Journal of neurology, neurosurgery, and psychiatry 2015-08-20 Drug development

    Effective interventions in diet, medications, biochemical exposures, psychological condition, pre-existing disease and lifestyle may decrease new incidence of AD.

  24. Cognitive reserve and lifestyle: moving towards preclinical Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Frontiers in aging neuroscience 2015-08-10 Risk factors

    The large majority of neuroimaging studies in Alzheimer's disease (AD) patients have supported the idea that lifestyle factors may protect against the clinical manifestations of AD rather than influence AD neuropathological processes (the cognitive reserve hypothesis).

  25. Mediterranean diet and preserved brain structural connectivity in older subjects

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2015-07-17 Prevention and risk

    In multivariate voxel-by-voxel analyses, adherence to the MeDi was significantly associated with preserved white matter microstructure in extensive areas, a gain in structural connectivity that was related to strong cognitive benefits.

  26. Association between comorbidities and dementia in diabetes mellitus patients: population-based retrospective cohort study

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Journal of diabetes and its complications 2015-06-29 Digital health tools

    Diabetic patients have an elevated risk of dementia, and comorbidity increases this risk.

  27. Associations between Potentially Modifiable Risk Factors and Alzheimer Disease: A Mendelian Randomization Study

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. PLoS medicine 2015-06-16 Drug development

    Inherited lifetime exposure to higher SBP is associated with lower AD risk.

  28. Gout and the risk of dementia: a nationwide population-based cohort study

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Arthritis research & therapy 2015-05-28 Digital health tools

    Patients with gout have a lower risk of developing dementia.

  29. Reduced plasma desmosterol-to-cholesterol ratio and longitudinal cognitive decline in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. Alzheimer's & dementia (Amsterdam, Netherlands) 2015-03-29 Biomarkers

    Plasma DES/CHO was significantly reduced in Japanese AD patients and significantly correlated with Mini-Mental State Examination (MMSE) score.

  30. Do statins impair cognition? A systematic review and meta-analysis of randomized controlled trials

    ✓ Peer-reviewed alzhub usefulness score 76 out of 100. Journal of general internal medicine 2015-01-10 Drug development

    Statin therapy was not associated with cognitive impairment in RCTs.

  31. Improved serum leptin and ghrelin following bariatric surgery predict better postoperative cognitive function

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Journal of clinical neurology (Seoul, Korea) 2015-01-02 Cognitive tests and assessment

    Improvements in leptin and ghrelin levels following bariatric surgery appear to contribute to postoperative cognitive benefits.

  32. Fatty acid profiles in demented patients: identification of hexacosanoic acid (C26:0) as a blood lipid biomarker of dementia

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of Alzheimer's disease : JAD 2015-01-01 Biomarkers

    The variations of fatty acid levels and the accumulation of C26:0 in the plasma and RBCs highlight an alteration of fatty acid metabolism in demented patients and point toward possible peroxisomal dysfunction.

  33. Mediterranean diet and cognitive health: an update of available knowledge

    ✓ Peer-reviewed alzhub usefulness score 66 out of 100. Current opinion in clinical nutrition and metabolic care 2015-01 Prevention and risk

    RECENT FINDINGS: Based on available epidemiological studies, two meta-analyses published in 2013 have underlined a protective effect of a greater MeDi adherence on cognitive health, including a reduced risk of Alzheimer's disease and cognitive impairment.

  34. Recent data on Mediterranean diet, cardiovascular disease, cancer, diabetes and life expectancy

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Bratislavske lekarske listy 2015 Prevention and risk

    Benefits of dietary moderation when on a Mediterranean diet type (MD) have been known for well over half a century.

  35. Motoric cognitive risk syndrome: Multicenter incidence study

    ✓ Peer-reviewed alzhub usefulness score 70 out of 100. Neurology 2014-10-31 Digital health tools

    The incidence of MCR is high in older adults.

  36. Cardiovascular risk factors and frontotemporal dementia: a case-control study

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Translational neurodegeneration 2014-06-21 Risk factors

    Cardiovascular risk factors (CRF) were widely described as related to dementia.

  37. Smoking and increased Alzheimer's disease risk: a review of potential mechanisms

    ✓ Peer-reviewed alzhub usefulness score 67 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2014-06-01 Prevention and risk

    A reduction in the incidence of smoking will likely reduce the future prevalence of AD.

  38. [Metabolic syndrome]

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Nihon rinsho. Japanese journal of clinical medicine 2014-04 Risk factors

    Considerable attention has focused on the prevention of dementia in terms of non-genetic risk factors, including midlife obesity, especially visceral obesity associated with hyperglycemia, hypertension, and hypercholesterolemia.

  39. Diabetes mellitus and the risk of Alzheimer's disease: a nationwide population-based study

    ✓ Peer-reviewed alzhub usefulness score 59 out of 100. PloS one 2014-01-29 Costs and economics

    Newly diagnosed DM was associated with increased risk of AD.

  40. Cardiovascular risk profile in women and dementia

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Journal of Alzheimer's disease : JAD 2014 Risk factors

    There is growing evidence for the importance of cardiovascular risk factors in dementia development, including Alzheimer's disease.

  41. Statins and cognitive function: a systematic review

    ✓ Peer-reviewed alzhub usefulness score 67 out of 100. Annals of internal medicine 2013-11-01 Drug development

    Larger and better-designed studies are needed to draw unequivocal conclusions about the effect of statins on cognition.

  42. Improved memory function two years after bariatric surgery

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Obesity (Silver Spring, Md.) 2013-10-15 Cognitive tests and assessment

    These findings suggest that cognitive benefits of bariatric surgery may extend to 24-months postoperatively.

  43. Statins and cognition: a systematic review and meta-analysis of short- and long-term cognitive effects

    ✓ Peer-reviewed alzhub usefulness score 76 out of 100. Mayo Clinic proceedings 2013-10-01 Drug development

    In patients without baseline cognitive dysfunction, short-term data are most compatible with no adverse effect of statins on cognition, and long-term data may support a beneficial role for statins in the prevention of dementia.

  44. Increased risk of cognitive impairment in patients with diabetes is associated with metformin

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. Diabetes care 2013-09-05 Drug development

    Metformin use was associated with impaired cognitive performance.

  45. Cognitive frailty: rational and definition from an (I.A.N.A./I.A.G.G.) international consensus group

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. The journal of nutrition, health & aging 2013-09-01 Prevention trials

    The frailty syndrome has recently attracted attention of the scientific community and public health organizations as precursor and contributor of age-related conditions (particularly disability) in older persons.

  46. Antihypertensive drugs decrease risk of Alzheimer disease: Ginkgo Evaluation of Memory Study

    ✓ Peer-reviewed alzhub usefulness score 78 out of 100. Neurology 2013-08-02 Drug development

    Diuretic, ARB, and ACE-I use was, in addition to and/or independently of mean systolic blood pressure, associated with reduced risk of AD dementia in participants with normal cognition, while only diuretic use was associated with reduced risk in participants with MCI.

  47. Development of a new method for assessing global risk of Alzheimer's disease for use in population health approaches to prevention

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Prevention science : the official journal of the Society for Prevention Research 2013-08-01 Prevention trials

    Alzheimer's disease (AD) affects approximately 35 million people worldwide.

  48. Risk Factors for β-Amyloid Deposition in Healthy Aging

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. JAMA Neurology 2013-03-18 Brain scans and imaging

    Participants in the hypertension group with at least 1 ε4 allele showed significantly greater amyloid burden than those with only 1 risk factor or no risk factors.

  49. Cerebral and extracerebral cholesterol metabolism and CSF markers of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Biochemical pharmacology 2013-01-03 Biomarkers

    The disturbances of the cholesterol synthesis and metabolism described in Alzheimer's disease (AD) may be both a consequence of the neurodegenerative process and a contributor to the pathogenesis.

  50. Biomarkers of Alzheimer's disease among Mexican Americans

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of Alzheimer's disease : JAD 2013-01-01 Drug development

    The biomarker profile for AD among Mexican American cases is significantly different from that previously identified among non-Hispanic cases from many large-scale studies.

From across this tag

6 of the 304 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 6. The same 6 appear here every time.

All topic tags with their study counts