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late-life-depression
139 studies tagged late-life-depression, dated 1972-06-01 to 2026-10-16. Bibliography: BibTeX (.bib) · RIS (.ris)
Newest in this topic
- The Role of Cortisol in CNS Disease –11β-HSD1 Inhibition as a Potential New Therapeutic Strategy for Alzheimer’s Disease and Major Depressive Disorder 2026-10-16
- Newly diagnosed postoperative depression and incident dementia after major surgery: a Korean nationwide retrospective cohort study 2026-09-30
- Brain Iron Accumulation and Its Cognitive and Olfactory Correlates in Late-Life Depression 2026-09-10
Studies
139 studies carry this tag.
Date range
1972 to 2026
Top journals
- Journal of affective disorders 6
- The British journal of psychiatry : the journal of mental science 6
- International journal of geriatric psychiatry 5
- Journal of Alzheimer's disease : JAD 4
- The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 4
94 journals in all.
Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.
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Lithium is an established treatment for affective disorders with good evidence of antisuicidal properties.
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Less than half of older adults with depression achieve remission with antidepressant medications, and rates of remission are even poorer for those with comorbid conditions.
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The age-adjusted smoking prevalence of adults with mental illness or serious psychological distress ranged from 34.3% (phobias or fears) to 59.1% (schizophrenia) compared with 18.3% of adults with no such illness.
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Major depressive disorder (MDD) has until recently been conceptualized as an episodic disorder associated with 'chemical imbalances' but no permanent brain changes.
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Continued treatment with lithium was associated with a reduced rate of dementia in patients with bipolar disorder in contrast to continued treatment with anticonvulsants, antidepressants, or antipsychotics.
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Recent studies revealed a mechanism that ties together these disparate effects of lithium.
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The increase in gray matter volume in these areas, which various neuroimaging and postmortem neuropathology studies have implicated in the neuropathophysiology of bipolar disorder, suggests that the observed effects may be linked to clinical response.
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38/100
Depression and cognitive impairment are both common conditions in old age, and frequently occur together.
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Continued lithium treatment was associated with reduction of the rate of dementia to the same level as that for the general population.
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The most common mental disorders that are currently prevalent in numerous countries are depression, bipolar disorder, schizophrenia, and obsessive-compulsive disorder (OCD).[2] The dietary intake pattern of the general population in many Asian and American countries reflects that they are often deficient in many nutrients, especially essential vitamins, minerals, and omega-3 fatty acids.[3] A notable feature of the diets of patients suffering from mental disorders is the severity of deficiency in these nutrients.[3] Studies have indicated that daily supplements of vital nutrients are often effective in reducing patients' symptoms.[4] Supplements containing amino acids have also been found to reduce symptoms, as they are converted to neurotransmitters which in turn alleviate depression and other mental health problems.[4] On the basis of accumulating scientific evidence, an effective therapeutic intervention is emerging, namely nutritional supplement/treatment.
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Increased levels of circulating AVP are also associated with the risk for suicide.
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Bipolar disorder is associated with increased risk for dementia.
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Clinical and pathological data from the Rush Memory and Aging Project were used to test the hypothesis that distress proneness is associated with increased risk of Alzheimer's disease (AD).
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Recent studies have shown that lithium may block the accumulation of amyloid-beta (Abeta) peptides and to inhibit the hyperphosphorylation of tau via the inhibition of GSK-3alpha in the brain of mice.
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A history of depression may confer an increased risk for later developing AD.
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Elevated plasma amyloid beta 1-42 (Abeta42) level has been linked to increased risk for incident AD in cognitively-intact elderly.
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Major depressive disorder is a potentially debilitating condition that often is unrecognized or undertreated in the elderly.
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In AD, the presence of a lifetime history of depression corresponds to increases in AD-related neuropathological changes within the hippocampus.
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ACTH release results in the release of corticosteroids from the adrenal that, subsequently, through mineralocorticoid and glucocorticoid receptors, exert negative feedback on, among other things, the hippocampus, the pituitary and the hypothalamus.
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The endocannabinoids are a family of bioactive lipids that activate CB1 cannabinoid receptors in the brain and exert intense emotional and cognitive effects.
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There is an increasing body evidence pointing to a close integration between the central nervous system (CNS) and immunological functions with lymphocytes playing therein a central role.
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Despite the use of a common, reliable methodology for the assessment and diagnosis of major depressive episodes, the prevalence of major depression in Alzheimer's disease ranged widely from 22.5% to 54.4% across the recruitment sites.
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Depression symptoms before the onset of AD are associated with the development of AD, even in families where first depression symptoms occurred more than 25 years before the onset of AD.
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This article focuses on diagnostic and nosologic challenges intrinsic to geriatric depression, including characteristics interfering with symptom and syndrome ascertainment, the impact of medical and cognitive disorders, the usefulness of screening instruments, and barriers imposed by treatment settings.
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38/100
Depression has an overall prevalence of 5-8%.
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A better understanding of the role of cytokines in various brain activities will enhance knowledge of specific psychobiological mechanisms in health and disease and provide opportunities for novel treatment interventions.
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Although mood disorders have traditionally been conceptualized as "neurochemical disorders," considerable literature from a variety of sources demonstrates significant reductions in regional central nervous system (CNS) volume and cell numbers (both neurons and glia) in persons with mood disorders.
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At baseline, 211 (3.6%) of the women had 6 or more depressive symptoms.
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These findings demonstrate that alpha-1 adrenoceptor stimulation in the PFC impairs cognitive function.
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If these results can be generalised then virtually all mental disorders have an increased risk of suicide excepting mental retardation and dementia.
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Twenty-one depressed patients with probable Alzheimer's disease (AD) were randomized to receive a 6-week treatment with clomipramine or placebo in a study with a double-blind crossover design.
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This article reviews the significance of the Geriatric Depression Scale (GDS) to practitioners and researchers in clinical gerontology, more than 10 years after the scale was introduced to the scientific community.
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Major depression is more common and more severe in patients with vascular dementia.
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57/100
The existing evidence paints an unclear picture of whether an association exists between depression and memory impairment.
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Considerable evidence has accrued in the last two decades to support the hypothesis that alterations in serotonergic neuronal function in the central nervous system occur in patients with major depression.
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Irreversible dementia developed significantly more frequently in the depressed group with reversible dementia (43%) than in the group with depression alone (12%).
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Depressive symptoms have been reported in patients with mild to moderate Alzheimer's disease (AD).
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The possibility that hypersecretion of corticotropin-releasing factor (CRF) contributes to the hyperactivity of the hypothalamo-pituitary-adrenal axis observed in patients with major depression was investigated by measuring the concentration of this peptide in cerebrospinal fluid of normal healthy volunteers and in drug-free patients with DSM-III diagnoses of major depression, schizophrenia, or dementia.
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The German psychiatrist Emil Kraepelin (1856 - 1926) is justly called father of modern psychiatry.
From across this tag
9 of the 139 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 9. The same 9 appear here every time.
- Omega-3 Use in Psychiatry: Evidence-Based or Elegance-Based?
- Newly diagnosed postoperative depression and incident dementia after major surgery: a Korean nationwide retrospective cohort study
- Distinguishing Apathy from Depression in Dementia: Implications for Diagnosis and Treatment
- Lithium in drinking water and Alzheimer's dementia: Epidemiological Findings from National Data Base of Japan
- Point Prevalence of Common Mental Health Conditions in Nigeria: A Systematic Review and Meta-Analysis
- Brain pathology and cognitive scores prior to onset of late-life depression
- Association of Lithium in Drinking Water With the Incidence of Dementia
- The role of cognitive and brain reserve in late-life depressive events: The Rotterdam Study
- Cerebrospinal fluid synaptic biomarker changes in bipolar disorder - A longitudinal case-control study