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late-life-depression
139 studies tagged late-life-depression, dated 1972-06-01 to 2026-10-16. Bibliography: BibTeX (.bib) · RIS (.ris)
Newest in this topic
- The Role of Cortisol in CNS Disease –11β-HSD1 Inhibition as a Potential New Therapeutic Strategy for Alzheimer’s Disease and Major Depressive Disorder 2026-10-16
- Newly diagnosed postoperative depression and incident dementia after major surgery: a Korean nationwide retrospective cohort study 2026-09-30
- Brain Iron Accumulation and Its Cognitive and Olfactory Correlates in Late-Life Depression 2026-09-10
Studies
139 studies carry this tag.
Date range
1972 to 2026
Top journals
- Journal of affective disorders 6
- The British journal of psychiatry : the journal of mental science 6
- International journal of geriatric psychiatry 5
- Journal of Alzheimer's disease : JAD 4
- The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 4
94 journals in all.
Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.
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Experimental data reveal that lithium is capable of attenuating Alzheimer's disease pathology and stimulating adult hippocampal neurogenesis.
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Fifty-eight of 77 patients (75.3%) completed the trial.
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Late-life depression remains an underdiagnosed clinical entity, mainly because the presence of cognitive impairment in the elderly leads clinicians to suspect dementia rather than depression.
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Late-life depression (LLD) is associated with an increased risk of all-cause dementia and may involve Alzheimer's disease pathology.
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The history of medical and psychiatric use of lithium dates back to more than one and a half-century ago.
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Although it is clear that nutrition affects physical and metabolic functions in humans, the importance of nutrition in mental illness has often been overlooked.
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Late-life depression is associated with significant cognitive impairment.
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This article covers current research on the relationship between depression and cognitive impairment in older adults.
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Participants in the placebo group displayed cognitive and functional decline, whereas lithium-treated patients remained stable over 2 years.
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Although cognitive and functional impairment are the hallmark features of Alzheimer's disease (AD), neuropsychiatric symptoms associated with AD account for increased rates of disability and profoundly impact the quality of life of both patients and their caregivers.
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Three major neurobiological features shared by LLD and AD include neurodegeneration, disruption to cerebrovascular functioning, and increased levels of neuroinflammation.
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Lithium as a mood stabilizer has been used as the standard pharmacological treatment for Bipolar Disorder (BD) for more than 60 years.
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Lithium-based medications are used successfully to treat many mental disorders, including bipolar disorder and Alzheimer's disease.
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We carried out systematic review and meta-analysis to evaluate whether peripheral levels of pro-inflammatory markers including Interleukin-1 beta (IL-1β), Interleukin-6 (IL-6), Tumor Necrosis Factor-α (TNF- α) and C-Reactive Protein (CRP) are significantly higher in elderly with depression and Alzheimer's disease.
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Kynurenine pathway (KP) activation is associated with many neuropsychiatric diseases, such as major depressive disorder (MDD) and Alzheimer's disease (AD).
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Major depressive disorder in the elderly-or late-life depression (LLD)-is one of the most common mental illnesses in the aging population.
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Late-life depression is a frequent and severe mental disorder.
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We then review new research on moderators of clinical response and how to use the information for improved efficacy.
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As persons age, their risk of developing late-life depression increases.
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The pattern is manifested in one or more of the following: a) engaging in repetitive sexual activities has become a central focus of the person's life to the point of neglecting health and personal care or other interests, activities and responsibilities; b) the person has made numerous unsuccessful efforts to control or significantly reduce repetitive sexual behaviour; c) the person continues to engage in repetitive sexual behaviour despite adverse consequences (e.g., repeated relationship disruption, occupational consequences, negative impact on health); or d) the person continues to engage in repetitive sexual behaviour even when he/she derives little or no satisfaction from it.
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Higher amyloid beta burden was associated with increasing anxious-depressive symptoms over time in cognitively normal older individuals.
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Data were available from 131 participants with age ranging from 65.4 to 88.2 years and mean follow up of 2.4 years (SD = 1.0).
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A number of biological and clinical characteristics typical of late life depression (LLD) have been suggested by recent research findings.
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Lithium therapy is generally accepted as a first-line treatment for bipolar disorder, and it is also identified as one of the best augmenting options for treatment-resistant depression.
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This article covers current research on the relationship between depression and cognitive impairment in older adults.
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Depression symptoms were observed in 33.8% of LTCF residents.
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A total of 73 731 patients with dementia and 733 653 controls (median age, 80.3 years; interquartile range, 74.9-84.6 years; 44 760 female [60.7%] and 28 971 male [39.3%]) were included in the study.
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Use of omega-3 in psychiatric practice is on the rise.
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We identified 63,347 cases with Alzheimer's disease and 126,694 controls.
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This article appraises several facets of the linkage between depression and cognitive impairment, including dementia, mild cognitive impairment, and vascular dementia.
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Depression and dementia are both common conditions in older people, and they frequently occur together.
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To elucidate an involvement of amyloid dysmetabolism in the pathophysiology of depression, we investigated associations of plasma amyloid-β (Aβ) levels with Alzheimer's disease-related changes in neuroimaging and cognitive dysfunction in patients with late-life depression.
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We studied neuroinflammation in individuals with late-life depression, as a risk factor for dementia, using [11C]PK11195 positron emission tomography (PET).
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There were nine inclusion/exclusion criteria that were used in more than half of the late life depression AETs: minimum severity on a symptom severity scale (100.0%), significant suicidal ideation (77.8%), psychotic features during the current episode of depression or history of a psychotic disorder (94.4%), history of bipolar disorder (77.8%), diagnosis of alcohol or drug abuse or dependence (83.3%), presence of a comorbid nondepressive, nonsubstance use Axis I disorder (55.6%), episode duration too short (66.7%), and an insufficient score on a cognitive screen (88.3%) or the presence of a cognitive disorder (55.6%).
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Higher scores on the appetite and weight loss symptom factor were associated with an increased hazard of both AD and non-AD dementia.
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GDS was not associated with cognitive status, NP score, Braak Stages, or their interaction.
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Depression is a frequent cause of morbidity in surgery patients suffering from a wide range of conditions.
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In the full cohort, 9.4% were diagnosed with major depression and 8.6% had chronically elevated depressive symptoms, both of which were related to adverse cognitive outcomes.
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Cognitive impairment in late-life depression is prevalent, disabling, and heterogeneous.
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Neuropsychiatric symptoms of Alzheimer’s disease (NPS-AD) are highly prevalent and lead to poor medical and functional outcomes.
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The results indicate that lithium treatment may have beneficial effects on cognitive performance in subjects with MCI and AD dementia.
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This brief report provides an introduction to the topic of cognitive functioning in late-life depression (LLD).
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Late life depression (LLD) frequently presents with cognitive impairment, and growing evidence suggests that these disease processes are "linked" in multiple ways.
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The purpose of this article is to identify the cognitive deficits commonly associated with geriatric depression and describe their clinical significance.
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A new Geriatric Depression Scale (GDS) designed specifically for rating depression in the elderly was tested for reliability and validity and compared with the Hamilton Rating Scale for Depression (HRS-D) and the Zung Self-Rating Depression Scale (SDS).
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Randomisation: Allocated 1 : 1 : 1 through Trials Unit, independently of trial team.
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The diagnostic criteria continued to result in rather frequent diagnosis of comorbidity.
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62/100
A lower incidence of dementia in bipolar patients treated with lithium has been described.
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They concluded that their results “challenge our understanding of major depression as a homogeneous categorical entity”.
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The present data support the notion that lithium has disease-modifying properties with potential clinical implications in the prevention of Alzheimer's disease.
From across this tag
8 of the 139 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 8. The same 8 appear here every time.
- Suicide as an outcome for mental disorders. A meta-analysis
- Does lithium protect against dementia?
- Lithium treatment and risk of dementia
- The prevalence, associations and symptoms of depression amongst dementia sufferers
- Role of serotonin in the pathophysiology of depression: focus on the serotonin transporter
- Chronic psychological distress and risk of Alzheimer's disease in old age
- A longitudinal study of the effects of lithium treatment on prefrontal and subgenual prefrontal gray matter volume in treatment-responsive bipolar disorder patients
- Course and outcomes of depression in the elderly