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Alzheimer degeneration in Down syndrome. Electrophysiologic alterations and histopathologic findings
Crapper DR, Dalton AJ, Skoptiz M, Scott JW, Hachinski VC.. Archives of neurology, 1975-09-01
Topic: Amyloid, tau and blood-test diagnosis
Progressive electroencephalographic disorganization and decreased voltage amplitude in the late components of the averaged visual evoked potentials were recorded in the last two years of life of a patient with Down disease and Alzheimer degeneration. Taken together with quantitative histopathologic findings, the electrophysiologic alterations are interpreted in terms of recent evidence from an experimental animal model of dementia. Neurons with neurofibrillary degeneration become electrically inactive and contribute to the loss of voltage generators associated with neuron death in Alzheimer disease. Loss of voltage generators may result in disfacillitation and disinhibition of surviving neurons, thus causing the loss of normal rhythms.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Crapper, D. R., Dalton, A. J., Skoptiz, M., Scott, J. W., & Hachinski, V. C. (1975). Alzheimer degeneration in Down syndrome. Electrophysiologic alterations and histopathologic findings. Archives of neurology. https://doi.org/10.1001/archneur.1975.00490510074006
Vancouver
Crapper DR, Dalton AJ, Skoptiz M, Scott JW, Hachinski VC. Alzheimer degeneration in Down syndrome. Electrophysiologic alterations and histopathologic findings. Archives of neurology. 1975. doi:10.1001/archneur.1975.00490510074006. PMID: 126052.
BibTeX
@article{crapper1975-126052,
author = {Crapper, D. R. and Dalton, A. J. and Skoptiz, M. and Scott, J. W. and Hachinski, V. C.},
title = {{Alzheimer degeneration in Down syndrome. Electrophysiologic alterations and histopathologic findings}},
journal = {Archives of neurology},
year = {1975},
doi = {10.1001/archneur.1975.00490510074006},
pmid = {126052},
url = {https://doi.org/10.1001/archneur.1975.00490510074006}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- Taken together with quantitative histopathologic findings, the electrophysiologic alterations are interpreted in terms of recent evidence from an experimental animal model of dementia.
- Neurons with neurofibrillary degeneration become electrically inactive and contribute to the loss of voltage generators associated with neuron death in Alzheimer disease.
- Loss of voltage generators may result in disfacillitation and disinhibition of surviving neurons, thus causing the loss of normal rhythms.
Why it matters
In one patient with Down syndrome and Alzheimer degeneration, progressive EEG disorganization and decreased visual evoked potential amplitude were recorded in the last two years of life and interpreted alongside histopathologic findings. This is a single-case observational study and does not test any treatment.
Study details
- Evidence strengthLow
How this study scored 37/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on institution's track record, so that was left out: it earned 36 of the 97 points we could judge it on, which is 37 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Archives of neurology) |
| Journal's citation record | 3 / 4 | Archives of Neurology: journal h-index 353 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 1975 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 4 / 7 | Cited 92 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 1.7 citations a year over 53 year(s) since 1975 |
| Impact for its field and year | 3 / 6 | Cited 4.9× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 8 other studies in this library |
| Still being cited | 0 / 4 | Cited 0 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Donald R. Crapper: h-index 21 (OpenAlex, whole career) |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 0 institution(s) in 0 countries — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 126052) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 36 / 97 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 36 of the 97 points we could judge it on is 37 out of 100. |
| Total | 37 / 100 | — |
What each of these 20 components measures, and what this score is not →
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