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Reexpression of a developmentally regulated antigen in Down syndrome and Alzheimer disease
Wolozin B, Scicutella A, Davies P.. Proceedings of the National Academy of Sciences of the United States of America, 1988-08-01
Topic: Brain proteins, microglia and lab models
ALZ-50 is a monoclonal antibody that recognizes a protein of apparent molecular mass 68 kilodaltons (A68). The protein is present in the brains of patients with Alzheimer disease but is not detectable in normal adult brain tissue. We now report that ALZ-50-reactive neurons are found in normal fetal and neonatal human brain and in brain tissue from neonatal individuals with Down syndrome. Reactive neurons decrease sharply in number after age 2 and reappear in older individuals with Down syndrome and in patients with Alzheimer disease.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Wolozin, B., Scicutella, A., & Davies, P. (1988). Reexpression of a developmentally regulated antigen in Down syndrome and Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. https://doi.org/10.1073/pnas.85.16.6202
Vancouver
Wolozin B, Scicutella A, Davies P. Reexpression of a developmentally regulated antigen in Down syndrome and Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. 1988. doi:10.1073/pnas.85.16.6202. PMID: 2970636.
BibTeX
@article{wolozin1988-2970636,
author = {Wolozin, B. and Scicutella, A. and Davies, P.},
title = {{Reexpression of a developmentally regulated antigen in Down syndrome and Alzheimer disease}},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
year = {1988},
doi = {10.1073/pnas.85.16.6202},
pmid = {2970636},
url = {https://doi.org/10.1073/pnas.85.16.6202}
}
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Key findings
- ALZ-50 is a monoclonal antibody that recognizes a protein of apparent molecular mass 68 kilodaltons (A68).
- The protein is present in the brains of patients with Alzheimer disease but is not detectable in normal adult brain tissue.
- We now report that ALZ-50-reactive neurons are found in normal fetal and neonatal human brain and in brain tissue from neonatal individuals with Down syndrome.
- Reactive neurons decrease sharply in number after age 2 and reappear in older individuals with Down syndrome and in patients with Alzheimer disease.
Why it matters
A protein called A68, recognized by the ALZ-50 antibody, was found in fetal and neonatal brain tissue and in older people with Down syndrome and Alzheimer's disease, but not in normal adult brain. This is a laboratory observation about protein expression and does not test any treatment or prevention.
Study details
- Evidence strengthLow
How this study scored 41/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Proceedings of the National Academy of Sciences of the United States of America) |
| Journal's citation record | 4 / 4 | Proceedings of the National Academy of Sciences: journal h-index 1,167 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 1988 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 104 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 2.6 citations a year over 40 year(s) since 1988 |
| Impact for its field and year | 4 / 6 | Cited 11.8× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 4 other studies in this library |
| Still being cited | 0 / 4 | Cited 2 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 3 / 4 | Last-listed author Peter Davies: h-index 92 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Albert Einstein College of Medicine: institution h-index 973 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 2970636) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 41 / 100 | — |
What each of these 20 components measures, and what this score is not →
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Also tagged “down”
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