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33/100

✓ Peer-reviewed alzhub usefulness score 33 out of 100. Down syndrome and Alzheimer's

Topic: Amyloid, tau and blood-test diagnosis

Platelets are the main source of 5-hydroxytryptamine (5-HT) and amyloid precursor protein (APP) found in plasma. We studied a possible correlation between platelet markers and the clinical diagnosis of Alzheimer disease (AD). Our results indicate that in AD patients: (a) platelets are elevated, (b) their ability to accumulate 5-HT decreases and, (c) the kinetic parameters of 5-HT uptake are altered (decreased Km and Vmax), compared to non-demented healthy individuals. An aged Down syndrome patient presents even more deviant alterations. Our findings supports the idea that platelets may provide a systemic marker of AD, and eventually be useful for the clinical diagnosis of the disease.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Inestrosa, N. C., Alarcón, R., Arriagada, J., Donoso, A., & Alvarez, J. (1993). Platelet of Alzheimer patients: increased counts and subnormal uptake and accumulation of [14C]5-hydroxytryptamine. Neuroscience letters. https://doi.org/10.1016/0304-3940(93)90216-8

Vancouver

Inestrosa NC, Alarcón R, Arriagada J, Donoso A, Alvarez J. Platelet of Alzheimer patients: increased counts and subnormal uptake and accumulation of [14C]5-hydroxytryptamine. Neuroscience letters. 1993. doi:10.1016/0304-3940(93)90216-8. PMID: 8295739.

BibTeX

@article{inestrosa1993-8295739,
  author  = {Inestrosa, N. C. and Alarcón, R. and Arriagada, J. and Donoso, A. and Alvarez, J.},
  title   = {{Platelet of Alzheimer patients: increased counts and subnormal uptake and accumulation of [14C]5-hydroxytryptamine}},
  journal = {Neuroscience letters},
  year    = {1993},
  doi     = {10.1016/0304-3940(93)90216-8},
  pmid    = {8295739},
  url     = {https://doi.org/10.1016/0304-3940(93)90216-8}
}

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Key findings

Our results indicate that in AD patients: (a) platelets are elevated, (b) their ability to accumulate 5-HT decreases and, (c) the kinetic parameters of 5-HT uptake are altered (decreased Km and Vmax), compared to non-demented healthy individuals.
Our findings supports the idea that platelets may provide a systemic marker of AD, and eventually be useful for the clinical diagnosis of the disease.

Why it matters

Platelets were elevated and their ability to take up and accumulate serotonin was reduced in Alzheimer's disease patients compared with healthy individuals. The authors suggest platelets may provide a systemic marker of Alzheimer's disease, which is about diagnosis rather than treatment.

Study details

Evidence strengthLow

How this study scored 33/100

Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it. We have no data on senior author's track record, so that was left out: it earned 32 of the 96 points we could judge it on, which is 33 out of 100.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Neuroscience letters)
Journal's citation record	3 / 4	Neuroscience Letters: journal h-index 267 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	1 / 5	1993 — older than 20 years, still counted
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomized / blinded	0 / 2	No randomization or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	3 / 7	Cited 28 times (OpenAlex, 2026-10-10)
Citations per year	0 / 5	0.8 citations a year over 35 year(s) since 1993
Impact for its field and year	1 / 6	Cited 0.4× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	2 / 6	Cited by 3 other studies in this library
Still being cited	1 / 4	Cited 4 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	— / 4	OpenAlex's profile for last-listed author Jaime Alvarez holds only 6 work(s), too few to judge a track record — left out of this score
Institution's track record	0 / 3	University of Chile: institution h-index 541 (OpenAlex)
Multicenter collaboration	1 / 3	OpenAlex lists 2 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 8295739)
Free to read	0 / 2	Behind a paywall — scores zero
Points	32 / 96	Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 32 of the 96 points we could judge it on is 33 out of 100.
Total	33 / 100	—

What each of these 20 components measures, and what this score is not →

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