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Tau covariance patterns in Alzheimer's disease patients match intrinsic connectivity networks in the healthy brain
Rik Ossenkoppele, Leonardo Iaccarino, Daniel R. Schonhaut, Jesse A. Brown, Renaud La Joie, James P. O’Neil, Mustafa Janabi, Suzanne L. Baker et al.. NeuroImage Clinical, 2019-01-01
Topic: Plasma and spinal-fluid biomarkers
According to the network model of neurodegeneration, the spread of pathogenic proteins occurs selectively along connected brain regions. We tested in vivo whether the distribution of filamentous tau (measured with [ 18 F]flortaucipir-PET), fibrillar amyloid-β ([ 11 C]PIB-PET) and glucose hypometabolism ([ 18 F]FDG-PET) follows the intrinsic functional organization of the healthy brain. We included 63 patients with Alzheimer's disease (AD; 30 male, 63 ± 8 years) who underwent [ 18 F]flortaucipir, [ 11 C]PIB and [ 18 F]FDG PET, and 1000 young adults (427 male, 21 ± 3 years) who underwent task-free fMRI. We selected six predefined disease epicenters as seeds for whole-brain voxelwise covariance analyses to compare correlated patterns of tracer uptake across AD patients against fMRI intrinsic connectivity patterns in young adults. We found a striking convergence between [ 18 F]flortaucipir covariance patterns and intrinsic connectivity maps (range Spearman rho's: 0.32–0.78, p < .001), which corresponded with expected functional networks (range goodness-of-fit: 3.8–8.2). The topography of amyloid-β covariance patterns was more diffuse and less network-specific, while glucose hypometabolic patterns were more spatially restricted than tau but overlapped with functional networks. These findings suggest that the spatial patterns of tau and glucose hypometabolism observed in AD resemble the functional organization of the healthy brain, supporting the notion that tau pathology spreads through circumscribed brain networks and drives neurodegeneration. • Tau covariance patterns in AD resemble functional networks in young adults • Hypometabolic patterns spatially resemble tau pathology but are more restricted • Topography of Aβ pathology is more diffuse and less network specific • Tau pathology may spread through neural networks, driving neurodegeneration
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APA 7th
Ossenkoppele, R., Iaccarino, L., Schonhaut, D. R., Brown, J. A., La Joie, R., O’Neil, J. P., et al. (2019). Tau covariance patterns in Alzheimer's disease patients match intrinsic connectivity networks in the healthy brain. NeuroImage Clinical. https://doi.org/10.1016/j.nicl.2019.101848
Vancouver
Ossenkoppele R, Iaccarino L, Schonhaut DR, Brown JA, La Joie R, O’Neil JP, et al. Tau covariance patterns in Alzheimer's disease patients match intrinsic connectivity networks in the healthy brain. NeuroImage Clinical. 2019. doi:10.1016/j.nicl.2019.101848. PMID: 31077982.
BibTeX
@article{ossenkoppele2019-31077982,
author = {Ossenkoppele, Rik and Iaccarino, Leonardo and Schonhaut, Daniel R. and Brown, Jesse A. and La Joie, Renaud and O’Neil, James P. and Janabi, Mustafa and Baker, Suzanne L. and others},
title = {{Tau covariance patterns in Alzheimer's disease patients match intrinsic connectivity networks in the healthy brain}},
journal = {NeuroImage Clinical},
year = {2019},
doi = {10.1016/j.nicl.2019.101848},
pmid = {31077982},
url = {https://doi.org/10.1016/j.nicl.2019.101848}
}
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Key findings
- We found a striking convergence between [ 18 F]flortaucipir covariance patterns and intrinsic connectivity maps (range Spearman rho's: 0.32–0.78, p < .001), which corresponded with expected functional networks (range goodness-of-fit: 3.8–8.2).
- These findings suggest that the spatial patterns of tau and glucose hypometabolism observed in AD resemble the functional organization of the healthy brain, supporting the notion that tau pathology spreads through circumscribed brain networks and drives neurodegeneration. • Tau covariance patterns in AD resemble functional networks in young adults • Hypometabolic patterns spatially resemble tau pathology but are more restricted • Topography of Aβ pathology is more diffuse and less network specific • Tau pathology may spread through neural networks, driving neurodegeneration
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Study details
- Participants63
- Evidence strengthLow
How this study scored 48/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomized / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multicenter collaboration, so those were left out: it earned 28 of the 58 points we could judge it on, which is 48 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (NeuroImage Clinical) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2019 — within 10 year(s) of the newest study here |
| Sample size | 1 / 4 | 63 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multicenter collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 31077982) |
| Free to read | 2 / 2 | Free to read |
| Points | 28 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 28 of the 58 points we could judge it on is 48 out of 100. |
| Total | 48 / 100 | — |
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