Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.
Highest usefulness score first. Studies without a score come last.
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Study setting should be considered when evaluating SCD as a risk state for MCI and dementia.
Why it matters
Over about 3 years of yearly check-ups, older adults who reported memory worries (subjective cognitive decline) were more likely to move on to mild cognitive impairment if they had come to an academic memory clinic than if they were part of a general-population study. The study reports an adjusted hazard ratio of 15.97 for SCD (95% CI 6.08–42.02), but the people in each setting differed, so a risk figure from a memory clinic should not be applied to people in the wider community, or the other way round.
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Our findings support need for greater ACP discussions between patients and proxies.
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Recent research has linked age-related hearing loss to impaired performance across cognitive domains and increased risk for dementia diagnosis.
Why it matters
This paper links age-related hearing loss to poorer cognitive performance and a higher risk of dementia diagnosis, and suggests possible behavioral and neural reasons for the link. It proposes suggestions for clinicians and a research agenda but does not report a proven way to prevent or treat dementia.
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So-called idiopathic rapid eye movement (REM) sleep behaviour disorder (RBD), formerly seen as a rare parasomnia, is now recognized as the prodromal stage of an α-synucleinopathy.
Why it matters
This review describes idiopathic REM sleep behaviour disorder as the prodromal stage of an alpha-synucleinopathy and as a possible opportunity for disease-modifying intervention. It discusses biomarkers for predicting progression, not a treatment, cure or prevention for Alzheimer's disease.
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Our results provide the first empirical evidence of CF in China.
Why it matters
This study estimated the prevalence of cognitive frailty in China and found depression and hearing impairment were associated factors. It describes prevalence and associated factors and does not test any treatment, cure or prevention.
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Disease-specific patterns of functional network topology and connectivity alterations were observed in patients with EOAD and bvFTD.
Why it matters
Patients with early-onset Alzheimer's disease showed widespread functional network disruption, while those with behavioral variant frontotemporal dementia had relatively preserved global architecture with more focal changes. This helps distinguish the two dementias by brain connectivity patterns, but it does not address treatment, cure or prevention.
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The two overarching themes lend themselves to interventions at a service level and a community level which need to happen in synergy.
Why it matters
This review combined qualitative studies on why ethnic minority groups in the UK have difficulty accessing dementia care, grouping findings into themes of 'inadequacies' and 'cultural habitus'. It addresses barriers to care and does not test any treatment, cure or prevention of Alzheimer's disease.
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52/100
Mild cognitive impairment or dementia is a risk for POD.
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Despite a common misconception, older adults engage in sexual behavior.
Why it matters
This cross-sectional study described the prevalence of sexual activity and physical tenderness and associated characteristics in 2,374 dementia-free older adults. It does not test any treatment, cure, or prevention of Alzheimer's disease.
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During the past ten years, an increasing number of controlled studies have assessed the potential rehabilitative effects of music-based interventions, such as music listening, singing, or playing an instrument, in several neurological diseases.
Why it matters
This review summarizes controlled studies of music-based interventions in neurological diseases including dementia, finding evidence for effects on cognition, motor function, or emotional wellbeing. It describes music-based rehabilitation as promising but states that further controlled studies are needed to establish efficacy.
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Caregivers of care recipients without dementia or disability accounted for the largest absolute number of helpers.
Why it matters
Using nationally representative U.S. surveys, this study found that although much larger proportions of older adults with dementia and disability received caregiving assistance, the largest absolute number receiving assistance were older adults without dementia or disability. It also found a significant linear association between the number of tasks provided and risk of caregiver burden in virtually all caregiver groups and domains of assistance.
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Dementia with Lewy bodies is the second most common form of neurodegenerative dementia, yet scarce evidence is available about its prognosis and natural history, which are crucial to inform clinical practice and research.
Why it matters
This review reports that people with dementia with Lewy bodies may have faster cognitive decline, shorter lifespan, and more residential care admission than people with Alzheimer's disease, with higher health-care costs and caregiver burden. Evidence on quality of life and hospital admission rates remains limited.
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Cerebral microbleeds (CMBs) are MRI markers attributed to the most common cerebral angiopathies in the elderly and in patients with dementia: hypertensive and cerebral amyloid angiopathy.
Why it matters
In Framingham Heart Study participants, this study examined whether cerebral microbleeds seen on MRI are linked to later dementia. Detecting these microbleeds may help identify people at risk, but the study does not show any treatment or way to prevent dementia.
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Identification of subjects at the early stages of Alzheimer's disease (AD) is fundamental for drug development and possible intervention or prevention of cognitive decline.
Why it matters
This paper describes how the concept of mild cognitive impairment evolved to identify people at risk of Alzheimer's, with an annual conversion rate of 5%-17%, and how subjective cognitive decline was introduced to capture an even earlier stage. It notes that earlier drug trials in mild cognitive impairment were disappointing and that more long-term studies are needed, but it reports no treatment.
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Our findings suggest that poor chewing ability is associated with cognitive impairment or dementia in the elderly living in rural area.
Why it matters
This cross-sectional study looked at whether chewing ability was linked to cognitive impairment in rural elderly people in Korea. It found that poor chewing ability was associated with higher risk of cognitive impairment, but it does not test any treatment or cure.
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The MEPA screener captures several components of the Mediterranean style pattern, although further testing of the MEPA screener is indicated.
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A projected doubling in the global population of people aged ≥60 y by the year 2050 has major health and economic implications, especially in developing regions.
Why it matters
This review states that burdens of unhealthy aging, including age-related diseases, may be largely preventable with lifestyle modification such as diet. It highlights nutritional frailty in older adults and discusses nutrition care for conditions including cognitive decline and dementia.
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A clinical tool can be used to predict 30-day mortality in patients hospitalized with lower gastrointestinal bleeding.
Why it matters
This study developed a clinical prediction tool for 30-day mortality in lower gastrointestinal bleeding that included dementia as one of eight variables. It is about predicting death risk in a different condition, not about treating or preventing Alzheimer's disease.
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52/100
Hospital-based palliative care is primarily utilized to clarify goals of care in neurological patients and that advance directives were commonly not completed prior to consultation.
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The estimated total annual costs of dementia in China increased from 0.9 billion United States dollars (US$) in 1990 to US$ 47.2 billion in 2010 and were predicted to reach US$ 69.0 billion in 2020 and US$ 114.2 billion in 2030.
Why it matters
In China, the yearly cost of dementia was estimated to rise from US$ 0.9 billion in 1990 to US$ 47.2 billion in 2010 and was predicted to reach US$ 114.2 billion by 2030, driven mainly by population ageing and rising dementia prevalence. Informal care, the unpaid work families do, made up 81–94% of the estimated cost between 1990 and 2010, which is why the authors call for a national dementia plan with integrated health and social care. This is a cost-modelling study. It does not test any treatment or prevention, and its 2020 and 2030 figures are projections.
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After carefully reviewing the literature, the group concluded that there were insufficient data to make evidence-based recommendations.
Why it matters
This scientific statement concludes that midlife hypertension has a harmful influence on late-life cognitive function, but that evidence from clinical trials that antihypertensive treatment improves cognition is not conclusive. It does not establish that treating hypertension prevents or cures Alzheimer's disease.
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Studies have yielded clues to the etiology and natural history of cognitive impairment in PD, but much remains unclear and effective therapies are needed.
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These relationships appear to differ between individuals who do and do not develop depression.
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Intervention participants in all four disease groups had less hospital use and lower hospital costs nonintervention participants, which drove lower overall healthcare costs.
Why it matters
This study found that a home-based palliative care program reduced hospital use and costs in the final months of life for participants, including those with dementia. It does not test any treatment, cure, or prevention for Alzheimer's disease.
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The Mediterranean diet is currently considered a functional diet with an increasing amount of scientific evidence that supports its beneficial effects in human health.
From across this topic
10 of the 7,967 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.
- Cognitive impairment in motor neuron disease with bulbar onset
- User evaluation of the DEMentia-specific Digital Interactive Social Chart (DEM-DISC). A pilot study among informal carers on its impact, user friendliness and, usefulness
- Visual assessment of atrophy on magnetic resonance imaging in the diagnosis of pathologically confirmed young-onset dementias
- Risk for Fractures with Centrally Acting Muscle Relaxants: An Analysis of a National Medicare Advantage Claims Database
- A systematic review and meta-analysis of the prevalence and associations of stress and burnout among staff in long-term care facilities for people with dementia
- Introduction of an open‐access national‐level U.S. dementia surveillance system
- Performance validity testing in neuropsychology: a clinical guide, critical review, and update on a rapidly evolving literature
- Prevalence and Factors Associated with Pain in Nursing Home Residents: A Systematic Review of the Literature
- Effects of Exercise Alone or Combined With Cognitive Training and Vitamin D Supplementation to Improve Cognition in Adults With Mild Cognitive Impairment: A Randomized Clinical Trial
- Multidomain Interventions to Prevent Cognitive Impairment, Alzheimer's Disease, and Dementia: From FINGER to World-Wide FINGERS