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You can call any of these for free. You do not need a diagnosis, an appointment, or a crisis to call — questions and plain exhaustion are reasons enough.

  • Alzheimer's Association 24/7 Helpline 800-272-3900 24 hours a day, 365 days a year Free, confidential support and information for people with dementia, caregivers, families and the public. Master's-level clinicians. Also Spanish.
  • 988 Suicide & Crisis Lifeline 988 24/7 Call or text 988, or chat at 988lifeline.org. For anyone in emotional distress or a mental-health crisis, including caregivers.
  • Alzheimer's Foundation of America (AFA) Helpline 866-232-8484 9:00 am - 9:00 pm ET, seven days a week Licensed social workers providing support, info and referrals. Also text message and web chat. Text: 646-586-5283

In a medical emergency, call 911. More numbers, and what each line does, on the help page.

Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Highest usefulness score first. Studies without a score come last.

  1. NLRP3 Inflammasome: A Potential Therapeutic Target in Fine Particulate Matter-Induced Neuroinflammation in Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Journal of Alzheimer's disease : JAD 2020 Inflammation and the immune system

    As one of the most harmful air pollutants, fine particulate matter (PM2.5) has been implicated as a risk factor for multiple diseases, which has generated widespread public concern.

  2. [Breathing: Ambient Air Pollution and Health - Part III]

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Pneumologie (Stuttgart, Germany) 2019-07-10 Risk factors

    The third part of the DGP statement introduces the current body of knowledge on less studied health outcomes associated with exposure to ambient air pollution: the negative impact on metabolism leading to impaired glucose tolerance and diabetes as well as contribution to the development of neurodegenerative disorders and delayed cognitive function in children.

  3. Association between exposure to air pollution and hippocampal volume in adults in the UK Biobank

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Neurotoxicology 2019-06-17 Risk factors

    In these models, PM2.5 concentration was associated with smaller left hippocampal volume.

  4. Dementia Around the World and the Latin America and Mexican Scenarios

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Journal of Alzheimer's disease : JAD 2019 Risk factors

    Dementia has become a major public health concern around the world.

  5. Fine Particulate Matter Exposure and Cerebrospinal Fluid Markers of Vascular Injury

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Journal of Alzheimer's disease : JAD 2019 Risk factors

    Among cognitively normal individuals, a 5 μg/m3 increase in 7-day and 1-year average PM2.5 was associated with elevated VCAM-1 (7-day: 35.4 (9.7, 61.1) ng/ml; 1-year: 51.8 (6.5, 97.1) ng/ml).

  6. Impact of air pollution on depression and suicide

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. International journal of occupational medicine and environmental health 2018-10-03 Risk factors

    Air pollution is one of the greatest public health threats worldwide.

  7. Danger in the Air: Air Pollution and Cognitive Dysfunction

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. American journal of Alzheimer's disease and other dementias 2018-06-06 Risk factors

    Air pollution is a multifaceted toxic chemical mixture capable of assaulting the central nervous system.

  8. Inflammatory effects of particulate matter air pollution

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Environmental science and pollution research international 2020-09-01 Risk factors

    Air pollution is an important cause of non-communicable diseases globally with particulate matter (PM) as one of the main air pollutants.

  9. Oxidative stress and mitochondrial dysfunction in organophosphate pesticide-induced neurotoxicity and its amelioration: a review

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Environmental science and pollution research international 2020-05-01 Risk factors

    Organophosphorus pesticides (OPs) are widely used for controlling pests worldwide.

  10. Emerging risk of environmental factors: insight mechanisms of Alzheimer's diseases

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Environmental science and pollution research international 2020-03-23 Risk factors

    Neurodegenerative disorders are typically sporadic in nature in addition to usually influenced through an extensive range of environmental factors, lifestyle, and genetic elements.

  11. Effects of air pollution on the nervous system and its possible role in neurodevelopmental and neurodegenerative disorders

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Pharmacology & therapeutics 2020-03-09 Risk factors

    Recent extensive evidence indicates that air pollution, in addition to causing respiratory and cardiovascular diseases, may also negatively affect the brain and contribute to central nervous system diseases.

  12. Pesticides, cognitive functions and dementia: A review

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Toxicology letters 2020-03-04 Risk factors

    Pesticides are widely-used chemicals commonly applied in agriculture for the protection of crops from pests.

  13. Traffic-related air pollutants (TRAP-PM) promote neuronal amyloidogenesis through oxidative damage to lipid rafts

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Free radical biology & medicine 2019-12-26 Risk factors

    Traffic-related air pollution particulate matter (TRAP-PM) is associated with increased risk of Alzheimer Disease (AD).

  14. Airborne, Vehicle-Derived Fe-Bearing Nanoparticles in the Urban Environment: A Review

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Environmental science & technology 2019-08-20 Risk factors

    Airborne particulate matter poses a serious threat to human health.

  15. Deaths: Leading Causes for 2017

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. National vital statistics reports : from the Centers for Disease Control and Prevention, National Center for Health Statistics, National Vital Statistics System 2019-06-01 Disparities

    In 2017, the 10 leading causes of death were, in rank order: Diseases of heart; Malignant neoplasms; Accidents (unintentional injuries); Chronic lower respiratory diseases; Cerebrovascular diseases; Alzheimer disease; Diabetes mellitus; Influenza and pneumonia; Nephritis, nephrotic syndrome and nephrosis; and Intentional self-harm (suicide).

  16. Ambient Air Pollution, Noise, and Late-Life Cognitive Decline and Dementia Risk

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Annual review of public health 2019-04-01 Risk factors

    Exposure to ambient air pollution and noise is ubiquitous globally.

  17. A review of the possible associations between ambient PM2.5 exposures and the development of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Ecotoxicology and environmental safety 2019-03-05 Risk factors

    PM2.5 particles in air pollution have been widely considered associated with respiratory and cardiovascular diseases.

  18. Metal Toxicity Links to Alzheimer's Disease and Neuroinflammation

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Journal of molecular biology 2019-01-18 Costs and economics

    As the median age of the population increases, the number of individuals with Alzheimer's disease (AD) and the associated socio-economic burden are predicted to worsen.

  19. Airborne Magnetite- and Iron-Rich Pollution Nanoparticles: Potential Neurotoxicants and Environmental Risk Factors for Neurodegenerative Disease, Including Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Journal of Alzheimer's disease : JAD 2019-01-01 Risk factors

    Fewer than 5% of Alzheimer's disease (AD) cases are demonstrably directly inherited, indicating that environmental factors may be important in initiating and/or promoting the disease.

  20. Neurotoxic effects of organophosphorus pesticides and possible association with neurodegenerative diseases in man: A review

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Toxicology 2018-09-25 Risk factors

    In this article the neurotoxic disorders appearing in patients exposed to organophosphorus pesticides and known mechanisms involved are reviewed.

  21. Hazardous effects of chemical pesticides on human health-Cancer and other associated disorders

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Environmental toxicology and pharmacology 2018-09-01 Genetics

    Poisoning from pesticides is a global public health problem and accounts for nearly 300,000 deaths worldwide every year.

  22. The link of organophosphorus pesticides with neurodegenerative and neurodevelopmental diseases based on evidence and mechanisms

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Toxicology 2018-07-24 Risk factors

    Organophosphorus (OP) compounds have been known as the most widely used pesticides during the past half century and there have been a huge body of literature regarding their association with human chronic diseases.

  23. There is growing evidence that air pollution is a risk factor for a number of neurodegenerative diseases, most notably Alzheimer's (AD) and Parkinson's (PD).

  24. Association of Low-Level Ozone with Cognitive Decline in Older Adults

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Journal of Alzheimer's disease : JAD 2018-01-01 Risk factors

    Increasing evidence points to an association of airborne pollutant exposure with respiratory, cardiovascular, and neurological pathology.

  25. Clinical effects of air pollution on the central nervous system; a review

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2017-05-18 Risk factors

    The purpose of this review is to describe recent clinical and epidemiological studies examining the adverse effects of urban air pollution on the central nervous system (CNS).

From across this topic

10 of the 294 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

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