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Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Highest usefulness score first. Studies without a score come last.

  1. Traffic-related air pollution impact on mouse brain accelerates myelin and neuritic aging changes with specificity for CA1 neurons

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Neurobiology of aging 2017-01-13 Risk factors

    Traffic-related air pollution (TRAP) is associated with lower cognition and reduced white matter volume in older adults, specifically for particulate matter <2.5-μm diameter (PM 2.5 ).

  2. Combustion-Derived Nanoparticles in Key Brain Target Cells and Organelles in Young Urbanites: Culprit Hidden in Plain Sight in Alzheimer's Disease Development

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Journal of Alzheimer's disease : JAD 2017-01-01 Risk factors

    Millions of children and young adults are exposed to fine particulate matter (PM2.5) and ozone, associated with Alzheimer's disease (AD) risk.

  3. Pesticides: an update of human exposure and toxicity

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Archives of toxicology 2016-10-08 Risk factors

    Pesticides are a family of compounds which have brought many benefits to mankind in the agricultural, industrial, and health areas, but their toxicities in both humans and animals have always been a concern.

  4. Neurotoxicity of traffic-related air pollution

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Neurotoxicology 2015-11-21 Risk factors

    The central nervous system is emerging as an important target for adverse health effects of air pollution, where it may contribute to neurodevelopmental and neurodegenerative disorders.

  5. Glyphosate’s Suppression of Cytochrome P450 Enzymes and Amino Acid Biosynthesis by the Gut Microbiome: Pathways to Modern Diseases

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Entropy 2013-04-18 Disease mechanisms

    Glyphosate, the active ingredient in Roundup®, is the most popular herbicide used worldwide.

  6. Cerebrospinal Fluid Biomarkers in Highly Exposed PM2.5 Urbanites: The Risk of Alzheimer's and Parkinson's Diseases in Young Mexico City Residents

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of Alzheimer's disease : JAD 2016-09-01 Risk factors

    Exposure to fine particulate matter (PM2.5) and ozone (O3) above US EPA standards is associated with Alzheimer's disease (AD) risk, while Mn toxicity induces parkinsonism.

  7. Millions of urban children are chronically exposed to high concentrations of air pollutants, i.e., fine particulate matter (PM2.5) and ozone, associated with increased risk for Alzheimer's disease.

  8. Air pollution, a rising environmental risk factor for cognition, neuroinflammation and neurodegeneration: The clinical impact on children and beyond

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Revue neurologique 2015-12-21 Risk factors

    Air pollution (indoors and outdoors) is a major issue in public health as epidemiological studies have highlighted its numerous detrimental health consequences (notably, respiratory and cardiovascular pathological conditions).

  9. Organophosphate pesticide exposure and neurodegeneration

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Cortex; a journal devoted to the study of the nervous system and behavior 2015-10-20 Risk factors

    Organophosphate pesticides (OPs) are used extensively throughout the world.

  10. Redox- and non-redox-metal-induced formation of free radicals and their role in human disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Archives of toxicology 2015-09-07 Disease mechanisms

    The depletion of zinc may enhance DNA damage by impairing DNA repair mechanisms.

  11. NLRP3 inflammasome activation by mitochondrial reactive oxygen species plays a key role in long-term cognitive impairment induced by paraquat exposure

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neurobiology of aging 2015-06-06 Risk factors

    Exposure to environmental toxins such as pesticides is implicated in increasing Alzheimer's disease risk.

  12. Air pollution and children: neural and tight junction antibodies and combustion metals, the role of barrier breakdown and brain immunity in neurodegeneration

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of Alzheimer's disease : JAD 2015-01-01 Risk factors

    Millions of children are exposed to concentrations of air pollutants, including fine particulate matter (PM2.5), above safety standards.

  13. Decreases in Short Term Memory, IQ, and Altered Brain Metabolic Ratios in Urban Apolipoprotein ε4 Children Exposed to Air Pollution

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of Alzheimer's disease : JAD 2015-01-01 Risk factors

    Children's urban air pollution exposures result in systemic and brain inflammation and the early hallmarks of Alzheimer's disease (AD).

  14. Megacities air pollution problems: Mexico City Metropolitan Area critical issues on the central nervous system pediatric impact

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Environmental research 2014-12-23 Risk factors

    The chronic health effects associated with sustained exposures to high concentrations of air pollutants are an important issue for millions of megacity residents and millions more living in smaller urban and rural areas.

  15. Free radicals: properties, sources, targets, and their implication in various diseases

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Indian journal of clinical biochemistry : IJCB 2014-07-15 Risk factors

    Free radicals and other oxidants have gained importance in the field of biology due to their central role in various physiological conditions as well as their implication in a diverse range of diseases.

  16. The contribution of vaccination to global health: past, present and future

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2014-05-12 Risk factors

    Vaccination has made an enormous contribution to global health.

  17. Pesticides exposure as etiological factors of Parkinson's disease and other neurodegenerative diseases--a mechanistic approach

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Toxicology letters 2014-02-03 Risk factors

    The etiology of most neurodegenerative disorders is multifactorial and consists of an interaction between environmental factors and genetic predisposition.

  18. Deaths: leading causes for 2010

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. National vital statistics reports : from the Centers for Disease Control and Prevention, National Center for Health Statistics, National Vital Statistics System 2013-12-01 Disparities

    In 2010, the 10 leading causes of death were, in rank order: Diseases of heart; Malignant neoplasms; Chronic lower respiratory diseases; Cerebrovascular diseases; Accidents (unintentional injuries); Alzheimer's disease; Diabetes mellitus; Nephritis, nephrotic syndrome and nephrosis; Influenza and pneumonia; and Intentional self-harm (suicide).

  19. Linking pesticide exposure and dementia: what is the evidence?

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Toxicology 2013-02-14 Risk factors

    There has been a steep increase in the prevalence of dementia in recent decades, which has roughly followed an increase in pesticide use some decades earlier, a time when it is probable that current dementia patients could have been exposed to pesticides.

  20. Pesticides and human chronic diseases: evidences, mechanisms, and perspectives

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Toxicology and applied pharmacology 2013-02-09 Risk factors

    Along with the wide use of pesticides in the world, the concerns over their health impacts are rapidly growing.

  21. Neuroactive insecticides: targets, selectivity, resistance, and secondary effects

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Annual review of entomology 2013-01-01 Risk factors

    Neuroactive insecticides are the principal means of protecting crops, people, livestock, and pets from pest insect attack and disease transmission.

  22. Neurotoxic potential of iron oxide nanoparticles in the rat brain striatum and hippocampus

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neurotoxicology 2012-09-18 Risk factors

    It has recently been reported that iron oxide nanoparticles (Fe(3)O(4)-NPs, 30 nm) have the ability to translocate directly from the olfactory nerve to the brain.

  23. Functional consequences of repeated organophosphate exposure: potential non-cholinergic mechanisms

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Pharmacology & therapeutics 2012-03-20 Risk factors

    The class of chemicals known as the "organophosphates" (OPs) comprises many of the most common agricultural and commercial pesticides that are used worldwide as well as the highly toxic chemical warfare agents.

  24. Neuroinflammation, hyperphosphorylated tau, diffuse amyloid plaques, and down-regulation of the cellular prion protein in air pollution exposed children and young adults

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of Alzheimer's disease : JAD 2012-01-01 Risk factors

    Air pollution exposures have been linked to neuroinflammation and neuropathology.

  25. Advances in metal-induced oxidative stress and human disease

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Toxicology 2011-03-23 Risk factors

    Detailed studies in the past two decades have shown that redox active metals like iron (Fe), copper (Cu), chromium (Cr), cobalt (Co) and other metals undergo redox cycling reactions and possess the ability to produce reactive radicals such as superoxide anion radical and nitric oxide in biological systems.

From across this topic

9 of the 294 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 9. The same 9 appear here every time.

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