Get help now — free helplines

You can call any of these for free. You do not need a diagnosis, an appointment, or a crisis to call — questions and plain exhaustion are reasons enough.

  • Alzheimer's Association 24/7 Helpline 800-272-3900 24 hours a day, 365 days a year Free, confidential support and information for people with dementia, caregivers, families and the public. Master's-level clinicians. Also Spanish.
  • 988 Suicide & Crisis Lifeline 988 24/7 Call or text 988, or chat at 988lifeline.org. For anyone in emotional distress or a mental-health crisis, including caregivers.
  • Alzheimer's Foundation of America (AFA) Helpline 866-232-8484 9:00 am - 9:00 pm ET, seven days a week Licensed social workers providing support, info and referrals. Also text message and web chat. Text: 646-586-5283

In a medical emergency, call 911. More numbers, and what each line does, on the help page.

Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Highest usefulness score first. Studies without a score come last.

  1. Smoking and increased Alzheimer's disease risk: a review of potential mechanisms

    ✓ Peer-reviewed alzhub usefulness score 67 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2014-06-01 Prevention and risk

    A reduction in the incidence of smoking will likely reduce the future prevalence of AD.

  2. Cigarette Smoking is a Risk Factor for Alzheimer's Disease: An Analysis Controlling for Tobacco Industry Affiliation

    ✓ Peer-reviewed alzhub usefulness score 67 out of 100. Journal of Alzheimer s Disease 2010-01-07 Prevention and risk

    To examine the relationship between smoking and Alzheimer's disease (AD) after controlling for study design, quality, secular trend, and tobacco industry affiliation of the authors, electronic databases were searched; 43 individual studies met the inclusion criteria.

  3. Integrating the environmental and genetic architectures of aging and mortality

    ✓ Peer-reviewed alzhub usefulness score 66 out of 100. Nature medicine 2025-02-19 Genetics

    Both environmental exposures and genetics are known to play important roles in shaping human aging.

  4. Air pollution is associated with faster cognitive decline in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 66 out of 100. Annals of clinical and translational neurology 2023-04-27 Risk factors

    Higher chronic exposure to SO2 was associated with a faster decline in memory score, whereas chronic exposure to CO, NO2 , and PM10 were not associated with the rate of cognitive decline.

  5. Association of Long-term Exposure to Ambient Air Pollution With Cognitive Decline and Alzheimer's Disease-Related Amyloidosis

    ✓ Peer-reviewed alzhub usefulness score 66 out of 100. Biological psychiatry 2022-05-18 Risk factors

    Long-term exposure to PM 2.5 contributed to the development of cognitive decline, which may be partly explained by brain amyloid accumulation indicative of increased AD risk.

  6. Urban green space and the risks of dementia and stroke

    ✓ Peer-reviewed alzhub usefulness score 66 out of 100. Environmental research 2020-04-17 Digital health tools

    Increased exposure to urban green space was associated with reduced incidence of dementia and stroke.

  7. Air Pollution and Alzheimer's Disease: A Systematic Review and Meta-Analysis

    ✓ Peer-reviewed alzhub usefulness score 66 out of 100. Journal of Alzheimer's disease : JAD 2020-01-01 Risk factors

    Air pollution exposure may exacerbate AD development.

  8. Air Pollution and Dementia: A Systematic Review

    ✓ Peer-reviewed alzhub usefulness score 66 out of 100. Journal of Alzheimer's disease : JAD 2019-01-01 Risk factors

    Evidence is emerging that greater exposure to airborne pollutants is associated with increased risk of dementia.

  9. Ambient ozone exposure and mental health: A systematic review of epidemiological studies

    ✓ Peer-reviewed alzhub usefulness score 66 out of 100. Environmental research 2018-05-01 Risk factors

    Current evidence for an association between ambient ozone exposure and mental health outcomes is inconclusive and further high quality studies are needed to assess any potential links given the strong biologic plausibility.

  10. Ambient air pollution and neurotoxicity on brain structure: Evidence from women's health initiative memory study

    ✓ Peer-reviewed alzhub usefulness score 66 out of 100. Annals of neurology 2015-07-28 Risk factors

    PM2.5 exposure may contribute to WM loss in older women.

  11. Increased Risk of Dementia in Patients With Chronic Obstructive Pulmonary Disease

    ✓ Peer-reviewed alzhub usefulness score 66 out of 100. Medicine 2015-06-01 Digital health tools

    Neurodegenerative disease in patients with chronic obstructive pulmonary disease (COPD) was observed.

  12. Neighborhood built environment associated with cognition and dementia risk among older adults: A systematic literature review

    ✓ Peer-reviewed alzhub usefulness score 64 out of 100. Social science & medicine (1982) 2021-11-09 Risk factors

    Cognitive impairment associated with aging is a serious and growing public health problem.

  13. Exposure to Air Pollution in Relation to Risk of Dementia and Related Outcomes: An Updated Systematic Review of the Epidemiological Literature

    ✓ Peer-reviewed alzhub usefulness score 64 out of 100. Environmental health perspectives 2021-09-24 Risk factors

    Strong conclusions remain elusive, although the weight of the evidence suggests an adverse association between PM2.5 and cognitive decline.

  14. Air Pollution Is Associated with Cognitive Deterioration of Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 64 out of 100. Gerontology 2021-04-21 Risk factors

    The PSI was higher in Kaohsiung and compared with Pingtung patients, Kaohsiung patients were exposed to higher average annual concentrations of CO, NO2, PM10, and SO2.

  15. Long-term effects of PM 2·5 on neurological disorders in the American Medicare population: a longitudinal cohort study

    ✓ Peer-reviewed alzhub usefulness score 64 out of 100. The Lancet. Planetary health 2020-10-19 Risk factors

    Between Jan 1, 2000, and Dec 31, 2016, of 63 038 019 individuals who were aged 65 years or older during the study period, we identified 1·0 million cases of Parkinson's disease and 3·4 million cases of Alzheimer's disease and related dementias based on primary and secondary diagnosis billing codes.

  16. We also identified several common challenges.

  17. Susceptibility to mortality in weather extremes: effect modification by personal and small-area characteristics

    ✓ Peer-reviewed alzhub usefulness score 64 out of 100. Epidemiology (Cambridge, Mass.) 2013-11-01 Costs and economics

    We identified several subgroups of the population who are particularly susceptible to temperature extremes, including persons with atrial fibrillation.

  18. Risk of dementia due to Co-exposure to air pollution and neighborhood disadvantage

    ✓ Peer-reviewed alzhub usefulness score 63 out of 100. Environmental research 2024-03-15 Risk factors

    SDI score (aHR = 1.08; 95% CI 0.96, 1.22), joint air pollution (aHR = 1.03, 95% CI 0.92, 1.16) and joint SDI with air pollution (aHR = 1.04, 95% CI 0.89, 1.22) were not associated with dementia risk.

  19. Association between air pollution and risk of vascular dementia: A multipollutant analysis in Taiwan

    ✓ Peer-reviewed alzhub usefulness score 63 out of 100. Environment international 2019-11-01 Risk factors

    Evidence regarding the association of specific air pollutants with vascular dementia (VaD) risk is limited.

  20. Cohort Profile Update: The Study of Health in Pomerania (SHIP)

    ✓ Peer-reviewed alzhub usefulness score 62 out of 100. International Journal of Epidemiology 2022-02-25 Drug development

    Therefore, respective software was developed in-house.8,9 Segmentation results are then analysed for potential associations with disease risks and to establish reference intervals of organ size and function.10 SHIP is also used as a basis for meta-research with a particular focus on incidental MRI findings and their effects on study participants.11,12 With its large amount of standardized data and the option to internally replicate findings from SHIP-START using data of the independent SHIP-TREND, the project offers good opportunities to apply new bioinformatical tools to mine the data and gain new insights into risk factors and pathomechanisms.

  21. Long-term effects of PM2.5 components on incident dementia in the northeastern United States

    ✓ Peer-reviewed alzhub usefulness score 62 out of 100. The Innovation 2022-01-17 Risk factors

    Growing evidence has linked long-term fine particulate matter (PM 2.5 ) exposure to neurological disorders.

  22. Impact of urban environmental exposures on cognitive performance and brain structure of healthy individuals at risk for Alzheimer's dementia

    ✓ Peer-reviewed alzhub usefulness score 62 out of 100. Environment international 2020-03-06 Risk factors

    In cognitively unimpaired adults with increased risk for AD, increased exposure to air pollution was suggested to be associated with greater global atrophy and reduced volume and thickness in specific brain areas known to be affected in AD, thus suggesting a potential link between environmental exposures and cerebral vulnerability to AD.

  23. Long-term exposure to air pollution and hospitalization for dementia in the Rome longitudinal study

    ✓ Peer-reviewed alzhub usefulness score 62 out of 100. Environmental health : a global access science source 2019-08-09 Risk factors

    Our results showed a positive association between exposure to NOx and O 3 and hospitalization for dementia and a negative association between NO 2 exposure and hospitalization for dementia.

  24. Anemia or low hemoglobin levels preceding Parkinson disease: a case-control study

    ✓ Peer-reviewed alzhub usefulness score 62 out of 100. Neurology 2009-10-01 Risk factors

    Our results support an association between anemia experienced early in life and the later development of Parkinson disease.

  25. Risk factors for Creutzfeldt-Jakob disease: a reanalysis of case-control studies

    ✓ Peer-reviewed alzhub usefulness score 62 out of 100. Neurology 1996-05-01 Risk factors

    To review the evidence for risk factors of Creutzfeldt-Jakob disease (CJD), we pooled and reanalyzed the raw data of three case-control studies.

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