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Air Pollution Is Associated with Cognitive Deterioration of Alzheimer's Disease
Feng Cheng Lin, Chih Yin Chen, Chung Wei Lin, Ming Tsang Wu, Hsuan Yu Chen, Poyin Huang. Gerontology, 2021-04-21
Topic: Air pollution and environmental exposures
The PSI was higher in Kaohsiung and compared with Pingtung patients, Kaohsiung patients were exposed to higher average annual concentrations of CO, NO2, PM10, and SO2. AD patients living in Kaohsiung suffered from faster cognitive deterioration in comparison with Pingtung patients (log-rank test: p = 0.016). When using multivariate Cox proportional hazards regression analysis, higher levels of CO, NO2, PM10, and SO2 exposure were associated with increased risk of AD cognitive deterioration. Among all these air pollutants, high SO2 exposure has the greatest impact while O3 has a neutral effect on AD cognitive deterioration. Air pollution is an environment-related risk factor that can be controlled and is associated with cognitive deterioration of AD. This finding could contribute to the implementation of public intervention strategies of AD.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Lin, F. C., Chen, C. Y., Lin, C. W., Wu, M. T., Chen, H. Y., & Huang, P. (2022). Air Pollution Is Associated with Cognitive Deterioration of Alzheimer's Disease. Gerontology. https://doi.org/10.1159/000515162
Vancouver
Lin FC, Chen CY, Lin CW, Wu MT, Chen HY, Huang P. Air Pollution Is Associated with Cognitive Deterioration of Alzheimer's Disease. Gerontology. 2022. doi:10.1159/000515162. PMID: 33882496.
BibTeX
@article{lin2022-33882496,
author = {Lin, Feng Cheng and Chen, Chih Yin and Lin, Chung Wei and Wu, Ming Tsang and Chen, Hsuan Yu and Huang, Poyin},
title = {{Air Pollution Is Associated with Cognitive Deterioration of Alzheimer's Disease}},
journal = {Gerontology},
year = {2022},
doi = {10.1159/000515162},
pmid = {33882496},
url = {https://doi.org/10.1159/000515162}
}
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Key findings
- The PSI was higher in Kaohsiung and compared with Pingtung patients, Kaohsiung patients were exposed to higher average annual concentrations of CO, NO2, PM10, and SO2.
- AD patients living in Kaohsiung suffered from faster cognitive deterioration in comparison with Pingtung patients (log-rank test: p = 0.016).
- When using multivariate Cox proportional hazards regression analysis, higher levels of CO, NO2, PM10, and SO2 exposure were associated with increased risk of AD cognitive deterioration.
- Among all these air pollutants, high SO2 exposure has the greatest impact while O3 has a neutral effect on AD cognitive deterioration.
- Air pollution is an environment-related risk factor that can be controlled and is associated with cognitive deterioration of AD.
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Study details
- Study designcase-control study
- Participants704
- Evidence strengthModerate
How this study scored 64/100
Published in a peer-reviewed journal, and it is a case-control study. Scored zero for effect reported and randomized / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multicenter collaboration and free to read, so those were left out: it earned 36 of the 56 points we could judge it on, which is 64 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Gerontology) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 6 / 12 | A case-control study |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2022 — within 6 year(s) of the newest study here |
| Sample size | 2 / 4 | 704 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multicenter collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 33882496) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 36 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 36 of the 56 points we could judge it on is 64 out of 100. |
| Total | 64 / 100 | — |
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