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A proteo-transcriptomic map of non-alcoholic fatty liver disease signatures
Govaere O, Hasoon M, Alexander L, Cockell S, Tiniakos D, Ekstedt M, Schattenberg JM, Boursier J et al.. Nature metabolism, 2023-04-10
Topic: Brain proteins, microglia and lab models
Non-alcoholic fatty liver disease (NAFLD) is a common, progressive liver disease strongly associated with the metabolic syndrome. It is unclear how progression of NAFLD towards cirrhosis translates into systematic changes in circulating proteins. Here, we provide a detailed proteo-transcriptomic map of steatohepatitis and fibrosis during progressive NAFLD.
Key findings
- It is unclear how progression of NAFLD towards cirrhosis translates into systematic changes in circulating proteins.
- Here, we provide a detailed proteo-transcriptomic map of steatohepatitis and fibrosis during progressive NAFLD.
- In this multicentre proteomic study, we characterize 4,730 circulating proteins in 306 patients with histologically characterized NAFLD and integrate this with transcriptomic analysis in paired liver tissue.
- We identify circulating proteomic signatures for active steatohepatitis and advanced fibrosis, and correlate these with hepatic transcriptomics to develop a proteo-transcriptomic signature of 31 markers.
Why it matters
This study provides a proteo-transcriptomic map of steatohepatitis and fibrosis in non-alcoholic fatty liver disease, characterizing circulating proteins in 306 patients. It concerns liver disease, not Alzheimer's disease, and reports no Alzheimer's treatment, cure or prevention.
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Study details
- Participants306
- Evidence strengthLow
How this study scored 56/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Nature metabolism) |
| Journal's citation record | 1 / 4 | Nature Metabolism: journal h-index 148 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2023 — within 6 year(s) of the newest study here |
| Sample size | 2 / 4 | 306 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 172 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 34.4 citations a year over 5 year(s) since 2023 |
| Impact for its field and year | 5 / 6 | Cited 29.3× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 3 / 4 | Cited 159 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Quentin Mark Anstee: h-index 115 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | KU Leuven: institution h-index 1,386 (OpenAlex) |
| Multi-centre collaboration | 3 / 3 | OpenAlex lists 17 institution(s) in 8 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 37037945) |
| Free to read | 2 / 2 | Free to read |
| Total | 56 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1038/s42255-023-00775-1
- PubMed: 37037945
- Original source →
- Free full text: Nature Metabolism →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Govaere, O., Hasoon, M., Alexander, L., Cockell, S., Tiniakos, D., Ekstedt, M., et al. (2023). A proteo-transcriptomic map of non-alcoholic fatty liver disease signatures. Nature metabolism. https://doi.org/10.1038/s42255-023-00775-1
Vancouver
Govaere O, Hasoon M, Alexander L, Cockell S, Tiniakos D, Ekstedt M, et al. A proteo-transcriptomic map of non-alcoholic fatty liver disease signatures. Nature metabolism. 2023. doi:10.1038/s42255-023-00775-1. PMID: 37037945.
BibTeX
@article{govaere2023-37037945,
author = {Govaere, O. and Hasoon, M. and Alexander, L. and Cockell, S. and Tiniakos, D. and Ekstedt, M. and Schattenberg, J. M. and Boursier, J. and others},
title = {{A proteo-transcriptomic map of non-alcoholic fatty liver disease signatures}},
journal = {Nature metabolism},
year = {2023},
doi = {10.1038/s42255-023-00775-1},
pmid = {37037945},
url = {https://doi.org/10.1038/s42255-023-00775-1}
}
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