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67/100

✓ Peer-reviewed alzhub usefulness score 67 out of 100. Biomarkers

Topic: Amyloid, tau and blood-test diagnosis

Results Among 641 participants with CSF Aβ42 data and at least two 18F-florbetapir scans, 335 (52.3%) were male. Higher stages were associated with lower CSF Aβ42 concentrations (from stage 1 at baseline), greater CSF P-tau (from stage 1) and CSF T-tau (from stage 2), and accelerated cognitive decline (from stage 2) and atrophy (from stage 3), even when adjusting for clinical diagnosis. The regions of different stages differed by gene expression profiles when using the transcriptome from the Allen Human Brain Atlas, especially involving genes associated with voltage-gated ion channel activity especially involving genes associated with voltage-gated ion channel activity, but also blood circulation, axon guidance, and lipid transportation. Conclusions and relevance Results of this study suggest that this robust staging system of Aβ accumulation may be useful for monitoring patients throughout the course of AD.

Key findings

Results Among 641 participants with CSF Aβ42 data and at least two 18F-florbetapir scans, 335 (52.3%) were male.
Higher stages were associated with lower CSF Aβ42 concentrations (from stage 1 at baseline), greater CSF P-tau (from stage 1) and CSF T-tau (from stage 2), and accelerated cognitive decline (from stage 2) and atrophy (from stage 3), even when adjusting for clinical diagnosis.
The regions of different stages differed by gene expression profiles when using the transcriptome from the Allen Human Brain Atlas, especially involving genes associated with voltage-gated ion channel activity especially involving genes associated with voltage-gated ion channel activity, but also blood circulation, axon guidance, and lipid transportation.
Conclusions and relevance Results of this study suggest that this robust staging system of Aβ accumulation may be useful for monitoring patients throughout the course of AD.

Why it matters

In 641 people who had at least two amyloid PET scans, higher stages of amyloid buildup were associated with lower spinal-fluid Aβ42 and higher P-tau from stage 1, higher T-tau and faster cognitive decline from stage 2, and brain shrinkage from stage 3, even after accounting for clinical diagnosis. This suggests that where amyloid has spread on a scan may track how far the disease has progressed. The authors conclude only that the staging "may be useful for monitoring patients throughout the course of AD". It describes associations, not causes, and it is not a treatment.

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Study details

Study designcohort study
Participants402
Effect size52.3%; 98.4%; 14.7%
Evidence strengthModerate

How this study scored 67/100

Published in a leading specialty journal, and it is a cohort study following people over time. Scored zero for randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	9 / 10	Tier 2 — leading specialty journal (JAMA neurology)
Journal's citation record	2 / 4	JAMA Neurology: journal h-index 235 (OpenAlex, 2026-10-29)
Study design	7 / 12	A cohort study following people over time
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	2 / 5	2019 — within 10 year(s) of the newest study here
Sample size	2 / 4	402 participants
Effect reported	2 / 3	Effect reported as a number, without an interval or test
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	5 / 7	Cited 235 times (OpenAlex, 2026-10-10)
Citations per year	4 / 5	26.1 citations a year over 9 year(s) since 2019
Impact for its field and year	4 / 6	Cited 16.5× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	3 / 6	Cited by 23 other studies in this library
Still being cited	3 / 4	Cited 104 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	4 / 4	Last-listed author Oskar Hansson: h-index 148 (OpenAlex, whole career)
Institution's track record	1 / 3	Lund University: institution h-index 1,119 (OpenAlex)
Multi-centre collaboration	1 / 3	OpenAlex lists 3 institution(s) in 2 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 31314895)
Free to read	0 / 2	Behind a paywall — scores zero
Total	67 / 100	—

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Read the original

Full text: free to read — PubMed Central lists this copy as free to read: the link above (checked 10 Oct 2026).

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.

APA 7th

Mattsson, N., Palmqvist, S., Stomrud, E., Vogel, J., & Hansson, O. (2019). Staging β-Amyloid Pathology With Amyloid Positron Emission Tomography. JAMA neurology. https://doi.org/10.1001/jamaneurol.2019.2214

Vancouver

Mattsson N, Palmqvist S, Stomrud E, Vogel J, Hansson O. Staging β-Amyloid Pathology With Amyloid Positron Emission Tomography. JAMA neurology. 2019. doi:10.1001/jamaneurol.2019.2214. PMID: 31314895.

BibTeX

@article{mattsson2019-31314895,
  author  = {Mattsson, N. and Palmqvist, S. and Stomrud, E. and Vogel, J. and Hansson, O.},
  title   = {{Staging β-Amyloid Pathology With Amyloid Positron Emission Tomography}},
  journal = {JAMA neurology},
  year    = {2019},
  doi     = {10.1001/jamaneurol.2019.2214},
  pmid    = {31314895},
  url     = {https://doi.org/10.1001/jamaneurol.2019.2214}
}

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