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Computerised cognitive training in Parkinson's disease: a protocol for a systematic review and updated meta-analysis
Hanna Malmberg Gavelin, Magdalena Domellöf, Isabella Leung, Anna Stigsdotter Neely, Carsten Finke, Amit Lampit. BMJ open, 2020-11-24
Topic: Brain imaging, connectivity and assessment
INTRODUCTION: Cognitive impairment is recognised as an important non-motor symptom in Parkinson's disease (PD) and there is a need for evidence-based non-pharmacological interventions that may prevent or slow cognitive decline in this patient group. One such intervention is computerised cognitive training (CCT), which has shown efficacious for cognition across older adult populations. This systematic review aims to investigate the efficacy of CCT across cognitive, psychosocial and functional domains for people with PD and examine study and intervention design factors that could moderate CCT effects on cognition. METHODS AND ANALYSIS: Randomised controlled trials investigating the effects of CCT in patients with PD without dementia, on cognitive, psychosocial or functional outcomes, will be included. The primary outcome is overall cognitive function. Secondary outcomes are domain-specific cognitive function, psychosocial functioning and functional abilities. We systematically searched MEDLINE, Embase and PsycINFO through 14 May 2020 to identify relevant literature. Risk of bias will be assessed using the revised Cochrane Risk of Bias tool. Effect sizes will be calculated as standardised mean difference of baseline to postintervention change (Hedges' g) with 95% CI for each eligible outcome measure. Pooling of outcomes across studies will be conducted using random-effects models, accounting for dependency structure of effect sizes within studies. Heterogeneity will be assessed using τ2 and I2 statistic. Potential moderators, based on key study and intervention design factors, will be investigated using mixed-effects meta-regression models. ETHICS AND DISSEMINATION: No ethical approval is required. The findings will be disseminated in a peer-reviewed scientific journal. PROSPERO REGISTRATION NUMBER: CRD42020185386.
Key findings
- The primary outcome is overall cognitive function.
Study details
- Study designsystematic review
- Evidence strengthHigh
How this study scored 68/100
Published in a peer-reviewed journal, and it is a systematic review of all the studies on the question. Scored zero for sample size, effect reported and studied in people because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 38 of the 56 points we could judge it on, which is 68 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (BMJ open) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 12 / 12 | A systematic review of all the studies on the question |
| Strength of evidence | 5 / 5 | Rated “high” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2020 — within 10 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | A review of other studies — randomisation is not credited here |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 33234647) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 38 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 38 of the 56 points we could judge it on is 68 out of 100. |
| Total | 68 / 100 | — |
What each of these 20 components measures, and what this score is not →
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APA 7th
Gavelin, H. M., Domellöf, M., Leung, I., Neely, A. S., Finke, C., & Lampit, A. (2020). Computerised cognitive training in Parkinson's disease: a protocol for a systematic review and updated meta-analysis. BMJ open. https://doi.org/10.1136/bmjopen-2020-040656
Vancouver
Gavelin HM, Domellöf M, Leung I, Neely AS, Finke C, Lampit A. Computerised cognitive training in Parkinson's disease: a protocol for a systematic review and updated meta-analysis. BMJ open. 2020. doi:10.1136/bmjopen-2020-040656. PMID: 33234647.
BibTeX
@article{gavelin2020-33234647,
author = {Gavelin, Hanna Malmberg and Domellöf, Magdalena and Leung, Isabella and Neely, Anna Stigsdotter and Finke, Carsten and Lampit, Amit},
title = {{Computerised cognitive training in Parkinson's disease: a protocol for a systematic review and updated meta-analysis}},
journal = {BMJ open},
year = {2020},
doi = {10.1136/bmjopen-2020-040656},
pmid = {33234647},
url = {https://doi.org/10.1136/bmjopen-2020-040656}
}