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63/100

✓ Peer-reviewed alzhub usefulness score 63 out of 100. Caregiving

Reviewed as evidence on: Sex, race, genetics and dementia risk after age 90 2 studies (what the news said). Being listed means the study bears on the question, not that it agrees with the news.

Topic: Risk, prevention and care in population studies

Objective The oldest old are the fastest growing segment of the US population, and accurate estimates of dementia incidence in this group are crucial for healthcare planning. Although dementia incidence doubles every 5 years from ages 65 to 90 years, it is unknown if this exponential increase continues past age 90 years. Here, we estimate age- and sex-specific incidence rates of all-cause dementia in people aged 90 years and older, including estimates for centenarians. Methods Participants are from The 90+ Study, a population-based longitudinal study of aging and dementia. Three hundred thirty nondemented participants aged 90 years and older at baseline were followed between January 2003 and December 2007. Age- and sex-specific incidence rates of all-cause dementia were estimated by person-years analysis. Results The overall incidence rate of all-cause dementia was 18.2% (95% confidence interval [CI], 15.3-21.5) per year and was similar for men and women (risk ratio, 0.94; 95% CI, 0.65-1.37). Rates increased exponentially with age from 12.7% per year in the 90-94-year age group, to 21.2% per year in the 95-99-year age group, to 40.7% per year in the 100+-year age group. The doubling time based on a Poisson regression was 5.5 years. Interpretation Incidence of all-cause dementia is very high in people aged 90 years and older and continues to increase exponentially with age in both men and women. Projections of the number of people with dementia should incorporate this continuing increase of dementia incidence after age 90 years. Our results foretell the growing public health burden of dementia in an increasingly aging population.

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APA 7th

Corrada, M. M., Brookmeyer, R., Paganini-Hill, A., Berlau, D., & Kawas, C. H. (2010). Dementia incidence continues to increase with age in the oldest old: the 90+ study. Annals of neurology. https://doi.org/10.1002/ana.21915

Vancouver

Corrada MM, Brookmeyer R, Paganini-Hill A, Berlau D, Kawas CH. Dementia incidence continues to increase with age in the oldest old: the 90+ study. Annals of neurology. 2010. doi:10.1002/ana.21915. PMID: 20186856.

BibTeX

@article{corrada2010-20186856,
  author  = {Corrada, M. M. and Brookmeyer, R. and Paganini-Hill, A. and Berlau, D. and Kawas, C. H.},
  title   = {{Dementia incidence continues to increase with age in the oldest old: the 90+ study}},
  journal = {Annals of neurology},
  year    = {2010},
  doi     = {10.1002/ana.21915},
  pmid    = {20186856},
  url     = {https://doi.org/10.1002/ana.21915}
}

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Key findings

Results The overall incidence rate of all-cause dementia was 18.2% (95% confidence interval [CI], 15.3-21.5) per year and was similar for men and women (risk ratio, 0.94; 95% CI, 0.65-1.37).
Our results foretell the growing public health burden of dementia in an increasingly aging population.

Why it matters

In people aged 90 and older, the incidence of all-cause dementia was very high and continued to increase exponentially with age, with similar rates in men and women. The authors say these results foretell a growing public health burden of dementia in an aging population, which is about planning for care rather than treatment or prevention.

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Study details

Study designlongitudinal study
Effect size18.2%; 12.7%; 21.2%
Evidence strengthModerate

How this study scored 63/100

Published in a leading specialty journal, and it is a longitudinal study following the same people over time. Scored zero for sample size, studied in people and randomized / blinded because the record does not state it.

Component	Points	Why
Journal tier	9 / 10	Tier 2 — leading specialty journal (Annals of neurology)
Journal's citation record	3 / 4	Annals of Neurology: journal h-index 437 (OpenAlex, 2026-10-29)
Study design	7 / 12	A longitudinal study following the same people over time
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	1 / 5	2010 — within 20 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	2 / 3	Effect reported as a number, without an interval or test
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomized / blinded	0 / 2	No randomization or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	6 / 7	Cited 523 times (OpenAlex, 2026-10-10)
Citations per year	4 / 5	29.1 citations a year over 18 year(s) since 2010
Impact for its field and year	4 / 6	Cited 11.1× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	3 / 6	Cited by 22 other studies in this library
Still being cited	3 / 4	Cited 98 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	3 / 4	Last-listed author Claudia H. Kawas: h-index 85 (OpenAlex, whole career)
Institution's track record	2 / 3	Johns Hopkins University: institution h-index 2,306 (OpenAlex)
Multicenter collaboration	1 / 3	OpenAlex lists 3 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 20186856)
Free to read	0 / 2	Behind a paywall — scores zero
Total	63 / 100	—

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Dementia incidence continues to increase with age in the oldest old: the 90+ study