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Prediction of continuous amyloid positron emission tomography with fluid measures of phosphorylated tau and β-amyloid
Niklas Mattsson, Linda Karlsson, Weizhong Tang, Kaj Blennow, Henrik Zetterberg, Randall John Bateman, Suzanne Elizabeth Schindler, Nicolas R. Barthélemy et al.. EMBO Molecular Medicine, 2025-12-01
Topic: Brain proteins, microglia and lab models
Abstract Brain amyloid-β (Aβ) pathology is a core feature of Alzheimer disease (AD) and can be quantified using positron emission tomography (PET). Cerebrospinal fluid (CSF) and plasma biomarkers detect abnormal Aβ, but it is unclear to what degree they can predict quantitative Aβ-PET. We explored plasma and CSF biomarkers in relation to Aβ-PET in the BioFINDER-2 study ( N = 1053), and the BioFINDER-1 study ( N = 238). We developed a machine learning pipeline to predict Aβ-PET using CSF and plasma measures. The best models achieved R 2 = 0.79. Plasma P-tau217 and CSF Aβ42/Aβ40 contributed the most. CSF Aβ42/Aβ40 contributed most to identify Aβ-positivity, while continuous Aβ-PET load within the positive range was best predicted by plasma P-tau217. Models using only plasma measures approached performance of CSF models. Altered metabolism of soluble Aβ may be highly associated with presence of Aβ plaques, while soluble P-tau217 levels may continue to change during build-up of Aβ pathology.
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APA 7th
Mattsson, N., Karlsson, L., Tang, W., Blennow, K., Zetterberg, H., Bateman, R. J., et al. (2025). Prediction of continuous amyloid positron emission tomography with fluid measures of phosphorylated tau and β-amyloid. EMBO Molecular Medicine. https://doi.org/10.1038/s44321-025-00348-7
Vancouver
Mattsson N, Karlsson L, Tang W, Blennow K, Zetterberg H, Bateman RJ, et al. Prediction of continuous amyloid positron emission tomography with fluid measures of phosphorylated tau and β-amyloid. EMBO Molecular Medicine. 2025. doi:10.1038/s44321-025-00348-7. PMID: 41326715.
BibTeX
@article{mattsson2025-41326715,
author = {Mattsson, Niklas and Karlsson, Linda and Tang, Weizhong and Blennow, Kaj and Zetterberg, Henrik and Bateman, Randall John and Schindler, Suzanne Elizabeth and Barthélemy, Nicolas R. and others},
title = {{Prediction of continuous amyloid positron emission tomography with fluid measures of phosphorylated tau and β-amyloid}},
journal = {EMBO Molecular Medicine},
year = {2025},
doi = {10.1038/s44321-025-00348-7},
pmid = {41326715},
url = {https://doi.org/10.1038/s44321-025-00348-7}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- Altered metabolism of soluble Aβ may be highly associated with presence of Aβ plaques, while soluble P-tau217 levels may continue to change during build-up of Aβ pathology.
Why it matters
Machine learning models using CSF and plasma measures predicted quantitative amyloid PET, with plasma P-tau217 and CSF Aβ42/Aβ40 contributing most. Models using only plasma measures approached the performance of CSF models, suggesting blood tests may help track amyloid burden without PET.
New to this subject? Start with our plain-English guide: Blood tests & biomarkers →
Study details
- Participants1,053
- Evidence strengthLow
How this study scored 46/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (EMBO Molecular Medicine) |
| Journal's citation record | 2 / 4 | EMBO Molecular Medicine: journal h-index 186 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 3 / 4 | 1,053 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 1 / 7 | Cited 2 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.7 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 2 / 6 | Cited 1.3× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 2 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Oskar Hansson: h-index 148 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | University College London: institution h-index 2,029 (OpenAlex) |
| Multi-centre collaboration | 3 / 3 | OpenAlex lists 14 institution(s) in 5 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 41326715) |
| Free to read | 2 / 2 | Free to read |
| Total | 46 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1038/s44321-025-00348-7
- PubMed: 41326715
- Original source →
- Free full text: EMBO Molecular Medicine →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
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