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41/100

✓ Peer-reviewed alzhub usefulness score 41 out of 100. Disease mechanisms

Topic: Amyloid, tau and blood-test diagnosis

• EEG microstate analyses were performed in a cohort of autosomal dominant AD. • Coverage of class C decreased in symptomatic mutation carriers • Coverage of class D decreased in presymptomatic and symptomatic mutation carriers. • Coverage of class E increased in presymptomatic and symptomatic mutation carriers. • The findings may support presymptomatic changes in resting-state neuronal networks. EEG microstates are transient and short-lasting periods of stable scalp potential fields that are associated with disturbed temporal dynamics of large-scale brain networks, affected by early synaptic loss in Alzheimer disease (AD). We investigated changes in EEG microstates in presymptomatic (PMC) and symptomatic mutation carriers (SMC) compared to healthy non-carrier (NC) controls in families with autosomal dominant AD (ADAD). A total of 99 EEG recordings from 7 SMC, 17 PMC and 24 NC were selected from a Swedish ADAD cohort. Seven classes (A to G) of microstate topographical maps were fitted to their resting-state EEG. Next, microstate parameters of coverage (fraction of total recording time), duration (average time in milliseconds) and occurrence (frequency per second) of different topographical maps were assessed in repeated-measures analyses to compare differences between NC, PMC and SMC. Selective decreases in coverage of class B (SMC vs NC, p = 0.023) and class C (SMC vs PMC and NC, p = 0.017 and p = 0.004) were observed in symptomatic individuals. In contrast, mutation carriers had a decrease in coverage of class D (SMC and PMC vs NC, p = 0.015 and p = 0.001) and an increase in coverage of class E compared to controls (SMC and PMC vs NC, both p = 0.001). Thus, global brain network dynamics as described by EEG microstate classes were selectively affected in this cohort of monogenic AD, associated with either clinical symptoms (class B and C) or mutation status (class D and E). The latter suggests early mutation-related changes that are detectable already in the presymptomatic stages.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Johansson, C., Koenig, T. W., Smailović, U., Hallström, V., Jelić, V., & Graff, C. (2025). Selective association of EEG microstates with clinical symptoms and mutation status in monogenic Alzheimer disease. NeuroImage Clinical. https://doi.org/10.1016/j.nicl.2025.103879

Vancouver

Johansson C, Koenig TW, Smailović U, Hallström V, Jelić V, Graff C. Selective association of EEG microstates with clinical symptoms and mutation status in monogenic Alzheimer disease. NeuroImage Clinical. 2025. doi:10.1016/j.nicl.2025.103879. PMID: 41005266.

BibTeX

@article{johansson2025-41005266,
  author  = {Johansson, Charlotte and Koenig, Thomas W. and Smailović, Una and Hallström, Vanessa and Jelić, Vesna and Graff, Caroline},
  title   = {{Selective association of EEG microstates with clinical symptoms and mutation status in monogenic Alzheimer disease}},
  journal = {NeuroImage Clinical},
  year    = {2025},
  doi     = {10.1016/j.nicl.2025.103879},
  pmid    = {41005266},
  url     = {https://doi.org/10.1016/j.nicl.2025.103879}
}

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Key findings

EEG microstates are transient and short-lasting periods of stable scalp potential fields that are associated with disturbed temporal dynamics of large-scale brain networks, affected by early synaptic loss in Alzheimer disease (AD).
We investigated changes in EEG microstates in presymptomatic (PMC) and symptomatic mutation carriers (SMC) compared to healthy non-carrier (NC) controls in families with autosomal dominant AD (ADAD).
In contrast, mutation carriers had a decrease in coverage of class D (SMC and PMC vs NC, p = 0.015 and p = 0.001) and an increase in coverage of class E compared to controls (SMC and PMC vs NC, both p = 0.001).
Thus, global brain network dynamics as described by EEG microstate classes were selectively affected in this cohort of monogenic AD, associated with either clinical symptoms (class B and C) or mutation status (class D and E).

Why it matters

In families with autosomal dominant Alzheimer's disease, EEG microstate coverage differed in presymptomatic and symptomatic mutation carriers compared with non-carriers, which may reflect early changes in resting-state neuronal networks. This is a small EEG study and does not test any treatment, cure or prevention.

Study details

Participants99
Evidence strengthModerate

How this study scored 41/100

Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (NeuroImage Clinical)
Journal's citation record	1 / 4	NeuroImage Clinical: journal h-index 133 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	1 / 4	99 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	1 / 7	Cited 2 times (OpenAlex, 2026-10-10)
Citations per year	0 / 5	0.7 citations a year over 3 year(s) since 2025
Impact for its field and year	2 / 6	Cited 1.3× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	0 / 4	Cited 2 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	3 / 4	Last-listed author Caroline Graff: h-index 79 (OpenAlex, whole career)
Institution's track record	1 / 3	Karolinska Institutet: institution h-index 1,477 (OpenAlex)
Multi-centre collaboration	1 / 3	OpenAlex lists 3 institution(s) in 2 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 41005266)
Free to read	2 / 2	Free to read
Total	41 / 100	—

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