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The Danish Alzheimer intervention study: rationale, study design and baseline characteristics of the cohort
Waldemar G, Waldorff FB, Buss DV, Eckermann A, Keiding N, Rishøj S, Siersma V, Sørensen J et al.. Neuroepidemiology, 2010-12-22
Topic: Amyloid, tau and blood-test diagnosis
Background There is a lack of appropriately designed trials investigating the efficacy of psychosocial interventions for patients with mild dementia and their family caregivers. This paper reports the rationale and design of the Danish Alzheimer Disease Intervention Study and baseline characteristics of the cohort. Methods The study was a 1-year multicentre randomized controlled rater-blinded trial with randomization to follow-up and a multifaceted semitailored intervention programme or to follow-up only (with extension of follow-up to 3 years). The intervention included a counselling programme, teaching courses, written information and logbooks. The outcomes included clinical efficacy parameters, patient satisfaction and health economic consequences. Results A total of 330 patients and their 330 caregivers were included during a period of 18 months. The majority (65.2 %) of the caregivers were spouses. At inclusion the mean age of the patients and caregivers was 76.2 and 66.0 years, respectively. Conclusion The study will explore the added value of a multifaceted intervention programme and contribute to the design of future interventions for patients with mild dementia and their caregivers.
Key findings
- Results A total of 330 patients and their 330 caregivers were included during a period of 18 months.
Why it matters
This paper describes the design and baseline characteristics of a Danish trial of a counselling and teaching programme for people with mild dementia and their caregivers. No results on whether the intervention works are reported here, so it cannot yet say anything about treating, curing, or preventing Alzheimer's disease.
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Study details
- Participants330
- Evidence strengthHigh
How this study scored 57/100
Published in a peer-reviewed journal, and it is a randomised controlled trial. Scored zero for effect reported because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Neuroepidemiology) |
| Journal's citation record | 1 / 4 | Neuroepidemiology: journal h-index 125 (OpenAlex, 2026-10-29) |
| Study design | 11 / 12 | A randomised controlled trial (from PubMed type “Randomized Controlled Trial”) |
| Strength of evidence | 5 / 5 | Rated “high” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2011 — within 20 year(s) of the newest study here |
| Sample size | 2 / 4 | 330 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 2 / 2 | Randomised and blinded or placebo-controlled (as stated in the record) |
| Times cited | 3 / 7 | Cited 28 times (OpenAlex, 2026-10-10) |
| Citations per year | 1 / 5 | 1.6 citations a year over 17 year(s) since 2011 |
| Impact for its field and year | 2 / 6 | Cited 2.0× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 1 other studies in this library |
| Still being cited | 1 / 4 | Cited 4 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 2 / 4 | Last-listed author Asmus Vogel: h-index 33 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | University of Copenhagen: institution h-index 1,378 (OpenAlex) |
| Multi-centre collaboration | 2 / 3 | OpenAlex lists 4 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 21196773) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 57 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
Full text: free to read — Unpaywall lists this copy as free to read: the link above (checked 10 Oct 2026).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Waldemar, G., Waldorff, F. B., Buss, D. V., Eckermann, A., Keiding, N., Rishøj, S., et al. (2011). The Danish Alzheimer intervention study: rationale, study design and baseline characteristics of the cohort. Neuroepidemiology. https://doi.org/10.1159/000322942
Vancouver
Waldemar G, Waldorff FB, Buss DV, Eckermann A, Keiding N, Rishøj S, et al. The Danish Alzheimer intervention study: rationale, study design and baseline characteristics of the cohort. Neuroepidemiology. 2011. doi:10.1159/000322942. PMID: 21196773.
BibTeX
@article{waldemar2011-21196773,
author = {Waldemar, G. and Waldorff, F. B. and Buss, D. V. and Eckermann, A. and Keiding, N. and Rishøj, S. and Siersma, V. and Sørensen, J. and others},
title = {{The Danish Alzheimer intervention study: rationale, study design and baseline characteristics of the cohort}},
journal = {Neuroepidemiology},
year = {2011},
doi = {10.1159/000322942},
pmid = {21196773},
url = {https://doi.org/10.1159/000322942}
}
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