Apolipoprotein E in sporadic Alzheimer's disease: Allelic variation and receptor interactions
George William Rebeck, Joell S. Reiter, Dudley K. Strickland, Bradley T. Hyman. Neuron, 1993-10-01
Topic: Amyloid, tau and blood-test diagnosis
We do not hold a plain-English summary of this study yet. Use the links to the original below for its abstract and findings.
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APA 7th
Rebeck, G. W., Reiter, J. S., Strickland, D. K., & Hyman, B. T. (1993). Apolipoprotein E in sporadic Alzheimer's disease: Allelic variation and receptor interactions. Neuron. https://doi.org/10.1016/0896-6273(93)90070-8
Vancouver
Rebeck GW, Reiter JS, Strickland DK, Hyman BT. Apolipoprotein E in sporadic Alzheimer's disease: Allelic variation and receptor interactions. Neuron. 1993. doi:10.1016/0896-6273(93)90070-8. PMID: 8398148.
BibTeX
@article{rebeck1993-8398148,
author = {Rebeck, George William and Reiter, Joell S. and Strickland, Dudley K. and Hyman, Bradley T.},
title = {{Apolipoprotein E in sporadic Alzheimer's disease: Allelic variation and receptor interactions}},
journal = {Neuron},
year = {1993},
doi = {10.1016/0896-6273(93)90070-8},
pmid = {8398148},
url = {https://doi.org/10.1016/0896-6273(93)90070-8}
}
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Key findings
- 62% of patients with sporadic Alzheimer's disease possessed an ApoE-epsilon 4 allele, compared with 20% of controls.
- ApoE-epsilon 4/4 patients had more senile plaques (SPs) than epsilon 3/3 patients.
- ApoE immunoreactivity of SPs was equivalent in both ApoE-epsilon 4/4 and epsilon 3/3 groups.
- In normal brain, anti-LRP antibodies strongly stained neurons and lightly stained astrocytes, whereas anti-LDL receptor antibodies stained only the neuropil and astrocytes.
- In Alzheimer's disease, SPs and reactive astrocytes were also strongly LRP immunoreactive, and colocalization of ApoE and LRP to SPs implies these molecules may be involved in metabolism of components of SPs.
Why it matters
Examines allelic variation in apolipoprotein E in sporadic Alzheimer's disease and the protein's interactions with receptors.
New to this subject? Start with our plain-English guide: Genetics →
How this study scored 54/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on strength of evidence, so that was left out: it earned 51 of the 95 points we could judge it on, which is 54 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Neuron) |
| Journal's citation record | 4 / 4 | Neuron: journal h-index 689 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | — / 5 | No evidence rating recorded — left out of this score |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 1993 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 7 / 7 | Cited 1,109 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 31.7 citations a year over 35 year(s) since 1993 |
| Impact for its field and year | 6 / 6 | Cited 44.9× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 3 / 4 | Cited 57 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Bradley T. Hyman: h-index 190 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | Massachusetts General Hospital: institution h-index 2,057 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 1 country |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 8398148) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 51 / 95 | Scored on 19 of 20 parts. We have no data for the rest, so they are left out: 51 of the 95 points we could judge it on is 54 out of 100. |
| Total | 54 / 100 | — |
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