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Optical coherence tomography angiography in preclinical Alzheimer's disease
van de Kreeke JA, Nguyen HT, Konijnenberg E, Tomassen J, den Braber A, Ten Kate M, Yaqub M, van Berckel B et al.. The British journal of ophthalmology, 2019-05-22
Topic: Amyloid, tau and blood-test diagnosis
Background/aims As a protrusion from the brain, the retina might reflect the status of the brain. Previous studies showed a decrease in vessel density and foveal avascular zone (FAZ) enlargement on optical coherence tomography angiography (OCTA) in individuals suffering from Alzheimer's disease (AD). This study aims to assess whether such changes are already present in preclinical stages of AD, in a population of monozygotic (MZ) twins. Methods 124 cognitively healthy individuals (MZ twins, ages 60-93 years) underwent [ 18 F]flutemetamol amyloid positron emission tomography (PET) scanning and OCTA. PET scans were visually rated for cortical amyloid-beta (Aβ) positivity. Parametric global cortical non-displaceable binding potential ( BP ND ) was used as a continuous measure for Aβ aggregation. FAZ size and vessel densities for the inner and outer ring of the macular ETDRS grid and in a 3-6 mm ring around the optic nerve head (ONH) were measured.OCTA measures were associated with visual Aβ score, BP ND and amyloid load estimated by twin concordance on visual Aβ score. Twin correlations were estimated as a measure of maximum heritability of OCTA measures. Results 13 of 124 participants were Aβ+. Aβ+ individuals had significantly higher vessel density than Aβ- individuals in all regions but did not differ in FAZ size. Twin analyses showed a positive association between and vessel densities in all regions. BP ND tended to be associated with higher vessel density in the inner ring. Twin correlations were moderate/high for all OCTA parameters except vessel density around the ONH, which correlated weakly. Conclusion Retinal vessel density was higher in individuals with preclinical AD.
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APA 7th
van de Kreeke, J. A., Nguyen, H. T., Konijnenberg, E., Tomassen, J., den Braber, A., Ten Kate, M., et al. (2020). Optical coherence tomography angiography in preclinical Alzheimer's disease. The British journal of ophthalmology. https://doi.org/10.1136/bjophthalmol-2019-314127
Vancouver
van de Kreeke JA, Nguyen HT, Konijnenberg E, Tomassen J, den Braber A, Ten Kate M, et al. Optical coherence tomography angiography in preclinical Alzheimer's disease. The British journal of ophthalmology. 2020. doi:10.1136/bjophthalmol-2019-314127. PMID: 31118186.
BibTeX
@article{vandekreeke2020-31118186,
author = {van de Kreeke, J. A. and Nguyen, H. T. and Konijnenberg, E. and Tomassen, J. and den Braber, A. and Ten Kate, M. and Yaqub, M. and van Berckel, B. and others},
title = {{Optical coherence tomography angiography in preclinical Alzheimer's disease}},
journal = {The British journal of ophthalmology},
year = {2020},
doi = {10.1136/bjophthalmol-2019-314127},
pmid = {31118186},
url = {https://doi.org/10.1136/bjophthalmol-2019-314127}
}
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Key findings
- FAZ size and vessel densities for the inner and outer ring of the macular ETDRS grid and in a 3-6 mm ring around the optic nerve head (ONH) were measured.OCTA measures were associated with visual Aβ score, BP ND and amyloid load estimated by twin concordance on visual Aβ score.
- Aβ+ individuals had significantly higher vessel density than Aβ- individuals in all regions but did not differ in FAZ size.
- BP ND tended to be associated with higher vessel density in the inner ring.
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Study details
- Participants124
- Evidence strengthLow
How this study scored 50/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 29 of the 58 points we could judge it on, which is 50 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (The British journal of ophthalmology) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2020 — within 10 year(s) of the newest study here |
| Sample size | 2 / 4 | 124 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 31118186) |
| Free to read | 2 / 2 | Free to read |
| Points | 29 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 29 of the 58 points we could judge it on is 50 out of 100. |
| Total | 50 / 100 | — |
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