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Optical coherence tomography angiography as a potential screening tool for cerebral small vessel diseases
Ju-Yeun Lee, Jun Pyo Kim, Hyemin Jang, Jaeho Kim, Sung Hoon Kang, Ji Sun Kim, Jongmin Lee, Young Hee Jung et al.. Alzheimer's research & therapy, 2020-06-11
Topic: Plasma and spinal-fluid biomarkers
The SVCI group showed lower CD in the temporal quadrant of the RPC network compared to the CN group (mean (SD), 42.34 (6.29) vs 48.45 (7.08); p = 0.001). When compared to the ADCI group, the SVCI showed lower CD in the superior quadrant (mean (SD), 60.14 (6.42) vs 64.15 (6.39); p = 0. 033) as well as in the temporal quadrant (ADCI 45.76, SVCI 42.34; p = 0.048) of the RPC network. The CD was negatively correlated with CSVD score in the superior (B (95%CI), - 0.059 (- 0.097 to - 0.021); p = 0.003) and temporal (B (95%CI), - 0.048 (- 0.080 to - 0.017); p = 0.003) quadrants of the RPC network. RNFL thickness did not differ among the groups nor did it correlate with cortical thickness. CONCLUSIONS AND RELEVANCE: The microvasculature of the RPC network was related to the CSVD burden. However, the RNFL thickness did not reflect cerebral neurodegeneration. Noninvasive and rapid acquisition of the OCTA image might have the potential to be used as a screening tool to detect CSVD.
Key findings
- The SVCI group showed lower CD in the temporal quadrant of the RPC network compared to the CN group (mean (SD), 42.34 (6.29) vs 48.45 (7.08); p = 0.001).
- When compared to the ADCI group, the SVCI showed lower CD in the superior quadrant (mean (SD), 60.14 (6.42) vs 64.15 (6.39); p = 0. 033) as well as in the temporal quadrant (ADCI 45.76, SVCI 42.34; p = 0.048) of the RPC network.
- The CD was negatively correlated with CSVD score in the superior (B (95%CI), - 0.059 (- 0.097 to - 0.021); p = 0.003) and temporal (B (95%CI), - 0.048 (- 0.080 to - 0.017); p = 0.003) quadrants of the RPC network.
- RNFL thickness did not differ among the groups nor did it correlate with cortical thickness.
- CONCLUSIONS AND RELEVANCE: The microvasculature of the RPC network was related to the CSVD burden.
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Study details
- Study designcross-sectional
- Participants69
- Evidence strengthLow
How this study scored 54/100
Published in a peer-reviewed journal, and it is a snapshot of people at one point in time. Scored zero for effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 30 of the 56 points we could judge it on, which is 54 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Alzheimer's research & therapy) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 4 / 12 | A snapshot of people at one point in time |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2020 — within 10 year(s) of the newest study here |
| Sample size | 1 / 4 | 69 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 32527301) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 30 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 30 of the 56 points we could judge it on is 54 out of 100. |
| Total | 54 / 100 | — |
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APA 7th
Lee, J.-Y., Kim, J. P., Jang, H., Kim, J., Kang, S. H., Kim, J. S., et al. (2020). Optical coherence tomography angiography as a potential screening tool for cerebral small vessel diseases. Alzheimer's research & therapy. https://doi.org/10.1186/s13195-020-00638-x
Vancouver
Lee J.-Y, Kim JP, Jang H, Kim J, Kang SH, Kim JS, et al. Optical coherence tomography angiography as a potential screening tool for cerebral small vessel diseases. Alzheimer's research & therapy. 2020. doi:10.1186/s13195-020-00638-x. PMID: 32527301.
BibTeX
@article{lee2020-32527301,
author = {Lee, Ju-Yeun and Kim, Jun Pyo and Jang, Hyemin and Kim, Jaeho and Kang, Sung Hoon and Kim, Ji Sun and Lee, Jongmin and Jung, Young Hee and others},
title = {{Optical coherence tomography angiography as a potential screening tool for cerebral small vessel diseases}},
journal = {Alzheimer's research \& therapy},
year = {2020},
doi = {10.1186/s13195-020-00638-x},
pmid = {32527301},
url = {https://doi.org/10.1186/s13195-020-00638-x}
}