Home › Research › Topics › preclinical
preclinical
4 studies tagged preclinical, dated 2021-02-06 to 2025-01-10. Bibliography: BibTeX (.bib) · RIS (.ris)
Newest in this topic
- Association and multimodal model of retinal and blood-based biomarkers for detection of preclinical Alzheimer's disease 2025-01-10
- Plasma pTau217 predicts continuous brain amyloid levels in preclinical and early Alzheimer's disease 2024-06-28
- Association of APOE ɛ4 and Plasma p-tau181 with Preclinical Alzheimer's Disease and Longitudinal Change in Hippocampus Function 2022-01-01
Studies
4 studies carry this tag.
Date range
2021 to 2025
Top journals
- Alzheimer's & dementia (Amsterdam, Netherlands) 1
- Alzheimer's & dementia : the journal of the Alzheimer's Association 1
- Alzheimer's research & therapy 1
- Journal of Alzheimer's disease : JAD 1
Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.
-
A subgroup cohort of 57 eyes from 32 participants with recent Aβ positron emission tomography (PET) results, comprising 18 preclinical patients (Aβ PET + ve, 32 eyes) and 14 controls (Aβ PET -ve, 25 eyes) with a mean age of 69 vs. 66, p = 0.06, was included for the assessment of a multimodal model to distinguish between the two groups.
-
55/100
Models integrating pTau217R outperformed Aβ42/Aβ40 alone, predicting amyloid levels up to 89.1 CL.
-
Our findings support an association of APOE ɛ4 and p-tau181 with preclinical AD and hippocampus functioning.
-
The Lumipulse platform provides comparable sensitivity and specificity to established CSF immunoassays in identifying pre-symptomatic AD pathology.