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33/100

✓ Peer-reviewed alzhub usefulness score 33 out of 100. Risk factors

Topic: Amyloid, tau and blood-test diagnosis

Older adults with MDD were more likely to endorse MBI. After adjustment, Aβ42/Aβ40 and p-tau217/np-tau217 positivity were associated with MBI among those with MDD but not among those without. Neuropsychatric symptoms (NPS) and biomarkers are AD risk factors. Early identification of MDD may reduce NPS severity, and tracking NPS onset, duration, and frequency is crucial for AD management.

Key findings

Older adults with MDD were more likely to endorse MBI.
After adjustment, Aβ42/Aβ40 and p-tau217/np-tau217 positivity were associated with MBI among those with MDD but not among those without.
Neuropsychatric symptoms (NPS) and biomarkers are AD risk factors.
Early identification of MDD may reduce NPS severity, and tracking NPS onset, duration, and frequency is crucial for AD management.

Why it matters

This study found that older adults with major depressive disorder were more likely to have mild behavioral impairment, and certain Alzheimer's blood biomarkers were linked to that impairment only in those with depression. It suggests early identification of depression may help manage symptoms, but it does not test a treatment or cure.

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Study details

Evidence strengthLow

How this study scored 33/100

Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring)
Journal's citation record	1 / 4	Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring: journal h-index 86 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	5 / 5	2026 — within 1 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	0 / 7	Cited 0 times (OpenAlex, 2026-10-10)
Citations per year	0 / 5	0.0 citations a year over 2 year(s) since 2026
Impact for its field and year	0 / 6	Cited 0.0× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	0 / 4	Cited 0 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	2 / 4	Last-listed author Ganesh Muneshwar Babulal: h-index 31 (OpenAlex, whole career)
Institution's track record	2 / 3	Washington University in St. Louis: institution h-index 1,962 (OpenAlex)
Multi-centre collaboration	1 / 3	OpenAlex lists 3 institution(s) in 3 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 42079383)
Free to read	2 / 2	Free to read
Total	33 / 100	—

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Read the original

Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.

APA 7th

Zhu, Y., Trani, J., Singh, R. K., Bekena, S., Williams, J., Lenze, E. J., et al. (2026). The association between major depressive disorder, plasma biomarkers of Alzheimer's disease, and mild behavioral impairment among older adults. Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring. https://doi.org/10.1002/dad2.70337

Vancouver

Zhu Y, Trani J, Singh RK, Bekena S, Williams J, Lenze EJ, et al. The association between major depressive disorder, plasma biomarkers of Alzheimer's disease, and mild behavioral impairment among older adults. Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring. 2026. doi:10.1002/dad2.70337. PMID: 42079383.

BibTeX

@article{zhu2026-42079383,
  author  = {Zhu, Yiqi and Trani, Jean‐Francois and Singh, Ramkrishna K. and Bekena, Semere and Williams, Jonathan and Lenze, Eric J. and Babulal, Ganesh Muneshwar},
  title   = {{The association between major depressive disorder, plasma biomarkers of Alzheimer's disease, and mild behavioral impairment among older adults}},
  journal = {Alzheimer s \& Dementia Diagnosis Assessment \& Disease Monitoring},
  year    = {2026},
  doi     = {10.1002/dad2.70337},
  pmid    = {42079383},
  url     = {https://doi.org/10.1002/dad2.70337}
}

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