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44/100

✓ Peer-reviewed alzhub usefulness score 44 out of 100. Tau biomarkers

Topic: Amyloid, tau and blood-test diagnosis

We found a positive main effect of CSF Aβ42/40 (p = 0.011) and p-tau181 (p = 0.012) on BC of the Dorsal Attention Network (DAN) (Figure 1). Significant interactions between Aβ42/40 and sex were observed on the APL, CC and Strength of the Default Mode Network (DMN) (Figure 2). Finally, significant interactions were observed between Aβ42/40 and graph metrics of the DMN- APL (p = 0.005), LE (p = 0.009), and CC (p = 0.008)- on PACC changes (Figure 3). Our data suggest that, in CU individuals, soluble Ab and p-tau exert opposite effects in the DAN information flow. Moreover, our interaction models suggest that a lower integration between DMN and the rest of the brain, as well as a lower centrality of DMN regions might be beneficial to preserve cognitive performance in the presence of AD. This study highlights the role of network topology in early AD and its potential to support cognitive resilience, providing potential targets for intervention.

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APA 7th

Lizarraga, A., Kassinopoulos, M., Gónzalez‐de‐Echávarri, J. M., Huguet, J., Sánchez‐Benavides, G., Grau‐Rivera, O., et al. (2025). Association of graph network properties with Alzheimer's pathological hallmarks early in the disease continuum. Alzheimer s & Dementia. https://doi.org/10.1002/alz70856_099727

Vancouver

Lizarraga A, Kassinopoulos M, Gónzalez‐de‐Echávarri JM, Huguet J, Sánchez‐Benavides G, Grau‐Rivera O, et al. Association of graph network properties with Alzheimer's pathological hallmarks early in the disease continuum. Alzheimer s & Dementia. 2025. doi:10.1002/alz70856_099727. PMID: 41447546.

BibTeX

@article{lizarraga2025-41447546,
  author  = {Lizarraga, Aldana and Kassinopoulos, Michalis and Gónzalez‐de‐Echávarri, José María and Huguet, Jordi and Sánchez‐Benavides, Gonzalo and Grau‐Rivera, Oriol and Suárez‐Calvet, Marc and Milà‐Alomà, Marta and others},
  title   = {{Association of graph network properties with Alzheimer's pathological hallmarks early in the disease continuum}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70856_099727},
  pmid    = {41447546},
  url     = {https://doi.org/10.1002/alz70856_099727}
}

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Key findings

We found a positive main effect of CSF Aβ42/40 (p = 0.011) and p-tau181 (p = 0.012) on BC of the Dorsal Attention Network (DAN) (Figure 1).
Significant interactions between Aβ42/40 and sex were observed on the APL, CC and Strength of the Default Mode Network (DMN) (Figure 2).
Finally, significant interactions were observed between Aβ42/40 and graph metrics of the DMN- APL (p = 0.005), LE (p = 0.009), and CC (p = 0.008)- on PACC changes (Figure 3).
Our data suggest that, in CU individuals, soluble Ab and p-tau exert opposite effects in the DAN information flow.
Moreover, our interaction models suggest that a lower integration between DMN and the rest of the brain, as well as a lower centrality of DMN regions might be beneficial to preserve cognitive performance in the presence of AD.

Why it matters

In cognitively unimpaired individuals, this study found that cerebrospinal fluid Aβ42/40 and p-tau181 were associated with network properties of the dorsal attention network, and that interactions between Aβ42/40 and default mode network metrics related to cognitive changes. The authors suggest network topology may support cognitive resilience and provide potential targets for intervention, but this is an observational study and does not test any treatment or cure.

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Study details

Study designlongitudinal study
Evidence strengthModerate

How this study scored 44/100

Published in a peer-reviewed journal, and it is a longitudinal study following the same people over time. Scored zero for sample size, effect reported, studied in people and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Alzheimer s & Dementia)
Journal's citation record	2 / 4	Alzheimer s & Dementia: journal h-index 228 (OpenAlex, 2026-10-29)
Study design	7 / 12	A longitudinal study following the same people over time
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	0 / 7	Cited 0 times (OpenAlex, 2026-10-10)
Citations per year	0 / 5	0.0 citations a year over 3 year(s) since 2025
Impact for its field and year	0 / 6	Cited 0.0× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	0 / 4	Cited 0 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	2 / 4	Last-listed author Raffaele Cacciaglia: h-index 29 (OpenAlex, whole career)
Institution's track record	2 / 3	University College London: institution h-index 2,029 (OpenAlex)
Multi-centre collaboration	3 / 3	OpenAlex lists 18 institution(s) in 5 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 41447546)
Free to read	2 / 2	Free to read
Total	44 / 100	—

What each of these 20 components measures, and what this score is not →

Read the original

Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

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