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White matter hyperintensities and Alzheimer's disease: An alternative view of an alternative hypothesis
Adam M Brickman, Batool Rizvi. Alzheimer's & dementia : the journal of the Alzheimer's Association, 2023-07-12
Topic: Plasma and spinal-fluid biomarkers
White matter hyperintensities (WMH) - - areas of increased signal appearing on T2-weighted magnetic resonance imaging - - are associated with Alzheimer’s disease (AD) risk and progression in late onset and genetic forms. Although typically attributable to macrostructural damage due to small vessel cerebrovascular disease or dysfunction, in a paper by Garnier-Crussard and colleagues[1], the authors review recent work suggesting an additional Wallerian-like component to WMH and argue that the elevated WMH seen in AD is a downstream phenomenon secondary to neurodegeneration. Here, we maintain that consideration of pathological correlates, animal work, brain perfusion patterns, longitudinal and incident data, and vascular risk factors provides evidence that is not inconsistent with a vasculogenic source of WMH. Future studies inspired by the consistent observations linking WMH to AD are needed to continue to understand potential vascular contributions to the disease.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Brickman, A. M., & Rizvi, B. (2023). White matter hyperintensities and Alzheimer's disease: An alternative view of an alternative hypothesis. Alzheimer's & dementia : the journal of the Alzheimer's Association. https://doi.org/10.1002/alz.13371
Vancouver
Brickman AM, Rizvi B. White matter hyperintensities and Alzheimer's disease: An alternative view of an alternative hypothesis. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023. doi:10.1002/alz.13371. PMID: 37437028.
BibTeX
@article{brickman2023-37437028,
author = {Brickman, Adam M and Rizvi, Batool},
title = {{White matter hyperintensities and Alzheimer's disease: An alternative view of an alternative hypothesis}},
journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
year = {2023},
doi = {10.1002/alz.13371},
pmid = {37437028},
url = {https://doi.org/10.1002/alz.13371}
}
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Key findings
- White matter hyperintensities (WMH) - - areas of increased signal appearing on T2-weighted magnetic resonance imaging - - are associated with Alzheimer’s disease (AD) risk and progression in late onset and genetic forms.
Study details
- Study designlongitudinal study
- Evidence strengthModerate
How this study scored 61/100
Published in a leading specialty journal, and it is a longitudinal study following the same people over time. Scored zero for sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 34 of the 56 points we could judge it on, which is 61 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Alzheimer's & dementia : the journal of the Alzheimer's Association) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2023 — within 6 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 37437028) |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 34 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 34 of the 56 points we could judge it on is 61 out of 100. |
| Total | 61 / 100 | — |
What each of these 20 components measures, and what this score is not →
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