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Prevalence and severity of microbleeds in a memory clinic setting
Cordonnier C, van der Flier WM, Sluimer JD, Leys D, Barkhof F, Scheltens P.. Neurology, 2006-05-01
Topic: Risk, prevention and care in population studies
Objective To determine prevalence and severity of microbleeds (MBs) in a large cohort of patients attending a memory clinic. Methods The authors consecutively included patients attending their memory clinic between January 2002 and April 2005. They analyzed prevalence and number of MBs according to demographic, diagnostic, and MRI data. Results The authors included 772 patients (53% men, age 66 +/- 11). One hundred twenty-seven patients (17%) exhibited at least one MB. The prevalence differed according to diagnostic groups (p Conclusion The prevalence of microbleeds (MBs) in a large cohort of patients attending a memory clinic is higher than previously described in community samples and lower than reported in stroke patients. This finding of a relatively high proportion of MBs in Alzheimer disease and mild cognitive impairment provides further evidence for the involvement of vascular factors in neurodegenerative diseases such as Alzheimer disease.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Cordonnier, C., van der Flier, W. M., Sluimer, J. D., Leys, D., Barkhof, F., & Scheltens, P. (2006). Prevalence and severity of microbleeds in a memory clinic setting. Neurology. https://doi.org/10.1212/01.wnl.0000210535.20297.ae
Vancouver
Cordonnier C, van der Flier WM, Sluimer JD, Leys D, Barkhof F, Scheltens P. Prevalence and severity of microbleeds in a memory clinic setting. Neurology. 2006. doi:10.1212/01.wnl.0000210535.20297.ae. PMID: 16682667.
BibTeX
@article{cordonnier2006-16682667,
author = {Cordonnier, C. and van der Flier, W. M. and Sluimer, J. D. and Leys, D. and Barkhof, F. and Scheltens, P.},
title = {{Prevalence and severity of microbleeds in a memory clinic setting}},
journal = {Neurology},
year = {2006},
doi = {10.1212/01.wnl.0000210535.20297.ae},
pmid = {16682667},
url = {https://doi.org/10.1212/01.wnl.0000210535.20297.ae}
}
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Key findings
- Results The authors included 772 patients (53% men, age 66 +/- 11).
Why it matters
Among 772 memory clinic patients, 17% had at least one microbleed, and prevalence differed by diagnosis, with a relatively high proportion in Alzheimer disease and mild cognitive impairment. The authors say this provides further evidence for vascular factors in neurodegenerative diseases, but it does not offer a treatment or cure.
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Study details
- Participants772
- Evidence strengthModerate
How this study scored 58/100
Published in a leading specialty journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Neurology) |
| Journal's citation record | 4 / 4 | Neurology: journal h-index 525 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2006 — older than 20 years, still counted |
| Sample size | 2 / 4 | 772 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 307 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 14.0 citations a year over 22 year(s) since 2006 |
| Impact for its field and year | 4 / 6 | Cited 8.2× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 3 / 6 | Cited by 24 other studies in this library |
| Still being cited | 2 / 4 | Cited 21 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Philip Scheltens: h-index 181 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Amsterdam UMC Location Vrije Universiteit Amsterdam: institution h-index 938 (OpenAlex) |
| Multi-centre collaboration | 1 / 3 | OpenAlex lists 2 institution(s) in 2 countries |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 16682667) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 58 / 100 | — |
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