Home › Research › How common it is
Neuroexposomics to Prevent Neurodegenerative Disease: Challenges, Next Steps, and Recommendations
Thakur NM, Staats KA.. Preprints.org, 2026-08-31
Topic: Air pollution and environmental exposures
Neuroexposome research investigates associations between physical, chemical, biological, and psychosocial factors and neurological health. It offers great potential to be meaningfully translated into reductions in the incidence of neurodegenerative diseases such as Alzheimer’s Disease, Parkinson’s Disease, and Amyotrophic Lateral Sclerosis. Current translational efforts focus on reducing exposure to identified risk factors through policy or behavior change. Here, we offer a more comprehensive framework for environmental and brain health communities to translate neuroexposomics into public health improvements, based on two premises: 1) Exposome risks are linked to multiple neurodegenerative diseases, therefore prevention efforts arising from neuroexposome research should adopt a multi-disease approach with composite endpoints; and 2) Neuroexposome research translation should consider all possible interventions, not limiting itself to decreased exposure of the risk factors only. A strategy to develop interventions to reduce the incidence of multiple neurodegenerative diseases by blocking harms identified through neuroexposome research is feasible and needed. After describing key challenges hindering the translational pipeline for these mitigations, we advocate for increased research capacity and funding to support large-scale confirmatory studies.
Key findings
- It offers great potential to be meaningfully translated into reductions in the incidence of neurodegenerative diseases such as Alzheimer’s Disease, Parkinson’s Disease, and Amyotrophic Lateral Sclerosis.
- Current translational efforts focus on reducing exposure to identified risk factors through policy or behavior change.
- Here, we offer a more comprehensive framework for environmental and brain health communities to translate neuroexposomics into public health improvements, based on two premises: 1) Exposome risks are linked to multiple neurodegenerative diseases, therefore prevention efforts arising from neuroexposome research should adopt a multi-disease approach with composite endpoints; and 2) Neuroexposome research translation should consider all possible interventions, not limiting itself to decreased exposure of the risk factors only.
- A strategy to develop interventions to reduce the incidence of multiple neurodegenerative diseases by blocking harms identified through neuroexposome research is feasible and needed.
- After describing key challenges hindering the translational pipeline for these mitigations, we advocate for increased research capacity and funding to support large-scale confirmatory studies.
New to this subject? Start with our plain-English guide: Alzheimer's in numbers →
Study details
- Evidence strengthLow
How this study scored 16/100
Preprint — not yet peer-reviewed. It scored 21 on the same rubric, but non-peer-reviewed sources are capped at 16, so it shows as 16. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 13 of the 62 points we could judge it on, which is 21 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 2 / 10 | Tier 4 — not a peer-reviewed journal (Preprints.org) |
| Journal's citation record | 0 / 4 | Not a journal article, so the journal's record does not count |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 4 / 10 | Preprint — not yet peer-reviewed. Hosted on a preprint server. |
| How recent | 5 / 5 | 2026 — within 1 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 1 / 2 | Not in PubMed, but has a DOI |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 13 / 62 | Scored on 12 of 20 parts. We have no data for the rest, so they are left out: 13 of the 62 points we could judge it on is 21 out of 100. |
| Total | 21 / 100 | Capped to 16 because this is not a peer-reviewed article. |
What each of these 20 components measures, and what this score is not →
Read the original
Free copy unknown: no free-copy check has an answer for this record yet. That does not mean it is paywalled.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Thakur, N. M., & Staats, K. A. (2026). Neuroexposomics to Prevent Neurodegenerative Disease: Challenges, Next Steps, and Recommendations. Preprints.org. https://doi.org/10.20944/preprints202608.2189.v1
Vancouver
Thakur NM, Staats KA. Neuroexposomics to Prevent Neurodegenerative Disease: Challenges, Next Steps, and Recommendations. Preprints.org. 2026. doi:10.20944/preprints202608.2189.v1.
BibTeX
@article{thakur2026-31310e7c,
author = {Thakur, N. M. and Staats, K. A.},
title = {{Neuroexposomics to Prevent Neurodegenerative Disease: Challenges, Next Steps, and Recommendations}},
journal = {Preprints.org},
year = {2026},
doi = {10.20944/preprints202608.2189.v1},
url = {https://doi.org/10.20944/preprints202608.2189.v1}
}
Related studies in How common it is
Also tagged “air”
237 studies in the library carry the topic tag “air”; these are this study's neighbours in a fixed, alphabetical-by-hash tour of them, not the closest in content. All 237 tagged studies.