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54/100

✓ Peer-reviewed alzhub usefulness score 54 out of 100. Mild cognitive impairment

Topic: Risk, prevention and care in population studies

When an individual with MCI-LB endorsed more clinical features, they typically experienced a faster cognitive decline (ACE-R Score Difference β = -1.1 [-1.7 to -0.5]), specifically when experiencing visual hallucinations (β = -2.1 [-3.5 to -0.8]) or cognitive fluctuations (β = -3.4 [-4.8 to -2.1]).Individuals with MCI-LB typically acquired more clinical features with the passage of time (25.5% [20.0-32.0%] one-year probability), limiting the prognostic utility of baseline-only features. The clinical presentation of MCI-LB may evolve over time. The accumulation of more clinical features of Lewy body disease, in particular visual hallucinations and cognitive fluctuations, may be associated with a worse prognosis in clinical settings.

Key findings

When an individual with MCI-LB endorsed more clinical features, they typically experienced a faster cognitive decline (ACE-R Score Difference β = -1.1 [-1.7 to -0.5]), specifically when experiencing visual hallucinations (β = -2.1 [-3.5 to -0.8]) or cognitive fluctuations (β = -3.4 [-4.8 to -2.1]).Individuals with MCI-LB typically acquired more clinical features with the passage of time (25.5% [20.0-32.0%] one-year probability), limiting the prognostic utility of baseline-only features.
The clinical presentation of MCI-LB may evolve over time.
The accumulation of more clinical features of Lewy body disease, in particular visual hallucinations and cognitive fluctuations, may be associated with a worse prognosis in clinical settings.

Why it matters

This study found that people with mild cognitive impairment with Lewy bodies who had more clinical features, especially visual hallucinations and cognitive fluctuations, declined faster. The clinical picture evolves over time, which may help prognosis, but no treatment or cure is tested.

Study details

Study designcohort study
Participants74
Effect size25.5%; 32.0%
Evidence strengthModerate

How this study scored 54/100

Published in a peer-reviewed journal, and it is a cohort study following people over time. Scored zero for randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Psychological Medicine)
Journal's citation record	3 / 4	Psychological Medicine: journal h-index 331 (OpenAlex, 2026-10-29)
Study design	7 / 12	A cohort study following people over time
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	1 / 4	74 participants
Effect reported	2 / 3	Effect reported as a number, without an interval or test
Studied in people	3 / 3	Studied in people (participant count stated)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	1 / 7	Cited 2 times (OpenAlex, 2026-10-10)
Citations per year	0 / 5	0.7 citations a year over 3 year(s) since 2025
Impact for its field and year	2 / 6	Cited 1.3× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	0 / 4	Cited 2 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	3 / 4	Last-listed author Alan J. Thomas: h-index 81 (OpenAlex, whole career)
Institution's track record	2 / 3	University College London: institution h-index 2,029 (OpenAlex)
Multi-centre collaboration	2 / 3	OpenAlex lists 6 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 40552972)
Free to read	2 / 2	Free to read
Total	54 / 100	—

What each of these 20 components measures, and what this score is not →

Read the original

Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.

APA 7th

Hamilton, C. A., Donaghy, P. C., Taylor, J., Ciafone, J., Durcan, R., Firbank, M. J., et al. (2025). Progression of clinical diagnostic features and cognitive decline in mild cognitive impairment with Lewy bodies. Psychological Medicine. https://doi.org/10.1017/s0033291725100895

Vancouver

Hamilton CA, Donaghy PC, Taylor J, Ciafone J, Durcan R, Firbank MJ, et al. Progression of clinical diagnostic features and cognitive decline in mild cognitive impairment with Lewy bodies. Psychological Medicine. 2025. doi:10.1017/s0033291725100895. PMID: 40552972.

BibTeX

@article{hamilton2025-40552972,
  author  = {Hamilton, Calum Alexander and Donaghy, Paul C. and Taylor, John‐Paul and Ciafone, Joanna and Durcan, Rory and Firbank, Michael John and Greenfinch, Gemma and Allan, Louise M. and others},
  title   = {{Progression of clinical diagnostic features and cognitive decline in mild cognitive impairment with Lewy bodies}},
  journal = {Psychological Medicine},
  year    = {2025},
  doi     = {10.1017/s0033291725100895},
  pmid    = {40552972},
  url     = {https://doi.org/10.1017/s0033291725100895}
}

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