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Mild cognitive impairment and Alzheimer disease: regional diffusivity of water
Kantarci K, Jack CR, Xu YC, Campeau NG, O'Brien PC, Smith GE, Ivnik RJ, Boeve BF et al.. Radiology, 2001-04-01
Topic: Amyloid, tau and blood-test diagnosis
Purpose To compare the regional diffusivity of water in the brains of normally aging elderly people and patients with mild cognitive impairment (MCI) or Alzheimer disease. Materials and methods Magnetic resonance images were obtained in 21 patients with Alzheimer disease, 19 patients with MCI, and 55 normally aging elderly control subjects without evidence of cognitive impairment. Regions of interest were drawn to compare the apparent diffusion coefficient (ADC) and the anisotropy index (AI) in frontal, parietal, temporal, occipital, anterior, and posterior cingulate white matter (WM), and the thalami and hippocampi. Results Hippocampal ADC was higher in MCI and Alzheimer disease patients than in control subjects. ADC of the temporal stem and posterior cingulate, occipital, and parietal WM was higher in Alzheimer disease patients than in control subjects. Except for occipital AI, which was lower in MCI patients than in control subjects, there were no differences in AI among the three groups for any of the regions. Conclusion Hippocampal ADC was significantly different between control subjects and MCI patients, many of whom likely have preclinical Alzheimer disease. Elevation in hippocampal ADC may reflect early ultrastructural changes in the progression of Alzheimer disease.
Key findings
- Results Hippocampal ADC was higher in MCI and Alzheimer disease patients than in control subjects.
- Conclusion Hippocampal ADC was significantly different between control subjects and MCI patients, many of whom likely have preclinical Alzheimer disease.
Why it matters
Hippocampal apparent diffusion coefficient was higher in people with mild cognitive impairment and Alzheimer's disease than in controls, while anisotropy index showed no differences among groups except in the occipital region. The authors suggest elevated hippocampal ADC may reflect early ultrastructural changes in Alzheimer's disease progression.
Study details
- Participants21
- Evidence strengthLow
How this study scored 50/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Radiology) |
| Journal's citation record | 3 / 4 | Radiology: journal h-index 431 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2001 — older than 20 years, still counted |
| Sample size | 1 / 4 | 21 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 303 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 11.2 citations a year over 27 year(s) since 2001 |
| Impact for its field and year | 4 / 6 | Cited 8.8× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 3 / 6 | Cited by 13 other studies in this library |
| Still being cited | 0 / 4 | Cited 2 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Ronald Carl Petersen: h-index 209 (OpenAlex, whole career) |
| Institution's track record | 2 / 3 | Mayo Clinic: institution h-index 1,606 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 11274543) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 50 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.1148/radiology.219.1.r01ap14101
- PubMed: 11274543
- Original source →
- Free full text: PubMed Central →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
APA 7th
Kantarci, K., Jack, C. R., Xu, Y. C., Campeau, N. G., O'Brien, P. C., Smith, G. E., et al. (2001). Mild cognitive impairment and Alzheimer disease: regional diffusivity of water. Radiology. https://doi.org/10.1148/radiology.219.1.r01ap14101
Vancouver
Kantarci K, Jack CR, Xu YC, Campeau NG, O'Brien PC, Smith GE, et al. Mild cognitive impairment and Alzheimer disease: regional diffusivity of water. Radiology. 2001. doi:10.1148/radiology.219.1.r01ap14101. PMID: 11274543.
BibTeX
@article{kantarci2001-11274543,
author = {Kantarci, K. and Jack, C. R. and Xu, Y. C. and Campeau, N. G. and O'Brien, P. C. and Smith, G. E. and Ivnik, R. J. and Boeve, B. F. and others},
title = {{Mild cognitive impairment and Alzheimer disease: regional diffusivity of water}},
journal = {Radiology},
year = {2001},
doi = {10.1148/radiology.219.1.r01ap14101},
pmid = {11274543},
url = {https://doi.org/10.1148/radiology.219.1.r01ap14101}
}
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