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Detecting earlier stages of amyloid deposition using PET in cognitively normal elderly adults
Guo T, Landau SM, Jagust WJ, Alzheimer's Disease Neuroimaging Initiative.. Neurology, 2020-03-18
Topic: Amyloid, tau and blood-test diagnosis
Objective To examine the feasibility of using cross-sectional PET to identify cognitive decliners among β-amyloid (Aβ)-negative cognitively normal (CN) elderly adults. Methods We determined the highest Aβ-affected region by ranking baseline and accumulation rates of florbetapir-PET regions in 355 CN elderly adults using 18 F-florbetapir-PET from the Alzheimer's Disease Neuroimaging Initiative (ADNI). The banks of the superior temporal sulcus (BANKSSTS) were found as the highest Aβ-affected region, and Aβ positivity in this region was defined as above the lowest boundary of BANKSSTS standardized uptake value ratio of Aβ+ (ADNI-defined COMPOSITE region) CN individuals. The entire CN cohort was divided as follows: stage 0, BANKSSTS-COMPOSITE-; stage 1, BANKSSTS+COMPOSITE-; and stage 2, BANKSSTS+COMPOSITE+. Linear mixed-effect (LME) models investigated subsequent longitudinal cognitive change, and 18 F-flortaucipir (FTP)-PET was measured 4.8 ± 1.6 years later to track tau deposition. Results LME analysis revealed that individuals in stage 1 (n = 64) and stage 2 (n = 99) showed 2.5 ( p < 0.05) and 4.8 ( p < 0.001) times faster memory decline, respectively, than those in stage 0 (n = 191) over >4 years of mean follow-up. Compared to stage 0, both stage 1 ( p < 0.05) and stage 2 ( p < 0.001) predicted higher FTP in entorhinal cortex. Conclusions Nominally Aβ- CN individuals with high Aβ in BANKSSTS are at increased risk of cognitive decline, probably showing an earlier stage of Aβ deposition. Our findings may help elucidate the association between brain Aβ accumulation and cognition in Aβ- CN cohorts. Classification of evidence This study provides Class II evidence that in elderly CN individuals those with high PET-identified superior temporal sulcus Aβ burden have an increased risk of cognitive decline.
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APA 7th
Guo, T., Landau, S. M., Jagust, W. J., & Alzheimer's Disease Neuroimaging Initiative. (2020). Detecting earlier stages of amyloid deposition using PET in cognitively normal elderly adults. Neurology. https://doi.org/10.1212/wnl.0000000000009216
Vancouver
Guo T, Landau SM, Jagust WJ, Alzheimer's Disease Neuroimaging Initiative. Detecting earlier stages of amyloid deposition using PET in cognitively normal elderly adults. Neurology. 2020. doi:10.1212/wnl.0000000000009216. PMID: 32188766.
BibTeX
@article{guo2020-32188766,
author = {Guo, T. and Landau, S. M. and Jagust, W. J. and {Alzheimer's Disease Neuroimaging Initiative}},
title = {{Detecting earlier stages of amyloid deposition using PET in cognitively normal elderly adults}},
journal = {Neurology},
year = {2020},
doi = {10.1212/wnl.0000000000009216},
pmid = {32188766},
url = {https://doi.org/10.1212/wnl.0000000000009216}
}
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Key findings
- Results LME analysis revealed that individuals in stage 1 (n = 64) and stage 2 (n = 99) showed 2.5 ( p < 0.05) and 4.8 ( p < 0.001) times faster memory decline, respectively, than those in stage 0 (n = 191) over >4 years of mean follow-up.
- Compared to stage 0, both stage 1 ( p < 0.05) and stage 2 ( p < 0.001) predicted higher FTP in entorhinal cortex.
- Conclusions Nominally Aβ- CN individuals with high Aβ in BANKSSTS are at increased risk of cognitive decline, probably showing an earlier stage of Aβ deposition.
- Our findings may help elucidate the association between brain Aβ accumulation and cognition in Aβ- CN cohorts.
- Classification of evidence This study provides Class II evidence that in elderly CN individuals those with high PET-identified superior temporal sulcus Aβ burden have an increased risk of cognitive decline.
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Study details
- Study designcross-sectional
- Participants64
- Evidence strengthModerate
How this study scored 59/100
Published in a leading specialty journal, and it is a snapshot of people at one point in time. Scored zero for effect reported and randomized / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multicenter collaboration, so those were left out: it earned 34 of the 58 points we could judge it on, which is 59 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 9 / 10 | Tier 2 — leading specialty journal (Neurology) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 4 / 12 | A snapshot of people at one point in time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 2 / 5 | 2020 — within 10 year(s) of the newest study here |
| Sample size | 1 / 4 | 64 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multicenter collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 32188766) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 34 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 34 of the 58 points we could judge it on is 59 out of 100. |
| Total | 59 / 100 | — |
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