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Objective subtle cognitive decline and plasma phosphorylated tau181: Early markers of Alzheimer's disease‐related declines
Kelsey R. Thomas, Katherine J. Bangen, Emily C. Edmonds, Alexandra J. Weigand, Kayla S. Walker, Mark W. Bondi, Douglas R. Galasko, for the Alzheimer's Disease Neuroimaging Initiative. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 2021-01
Topic: Plasma and spinal-fluid biomarkers
CU and Obj‐SCD has lower baseline p‐tau181 than MCI and did not differ from one another. Longitudinally, Obj‐SCD had the steepest p‐tau181 increase. Obj‐SCD/p‐tau181‐positive participants had the fastest rates of amyloid accumulation, cognitive decline, and functional decline. Despite assumptions that cognitive changes invariably follow biomarker changes, early neuropsychological difficulties may emerge before/concurrently with plasma p‐tau181 changes. Combining Obj‐SCD and p‐tau181, two potentially accessible early markers, was associated with the faster declines in AD‐related outcomes.
Key findings
- CU and Obj‐SCD has lower baseline p‐tau181 than MCI and did not differ from one another.
- Longitudinally, Obj‐SCD had the steepest p‐tau181 increase.
- Obj‐SCD/p‐tau181‐positive participants had the fastest rates of amyloid accumulation, cognitive decline, and functional decline.
- Despite assumptions that cognitive changes invariably follow biomarker changes, early neuropsychological difficulties may emerge before/concurrently with plasma p‐tau181 changes.
- Combining Obj‐SCD and p‐tau181, two potentially accessible early markers, was associated with the faster declines in AD‐related outcomes.
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Study details
- Study designlongitudinal study
- Participants402
- Evidence strengthModerate
How this study scored 64/100
Published in a peer-reviewed journal, and it is a longitudinal study following the same people over time. Scored zero for effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record, multi-centre collaboration and free to read, so those were left out: it earned 36 of the 56 points we could judge it on, which is 64 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 7 / 12 | A longitudinal study following the same people over time |
| Strength of evidence | 3 / 5 | Rated “moderate” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 3 / 5 | 2021 — within 6 year(s) of the newest study here |
| Sample size | 2 / 4 | 402 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 1 / 2 | Not in PubMed, but has a DOI |
| Free to read | — / 2 | Access not recorded — left out of this score |
| Points | 36 / 56 | Scored on 10 of 20 parts. We have no data for the rest, so they are left out: 36 of the 56 points we could judge it on is 64 out of 100. |
| Total | 64 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 8 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.
APA 7th
Thomas, K. R., Bangen, K. J., Edmonds, E. C., Weigand, A. J., Walker, K. S., Bondi, M. W., et al. (2021). Objective subtle cognitive decline and plasma phosphorylated tau181: Early markers of Alzheimer's disease‐related declines. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring. https://doi.org/10.1002/dad2.12238
Vancouver
Thomas KR, Bangen KJ, Edmonds EC, Weigand AJ, Walker KS, Bondi MW, et al. Objective subtle cognitive decline and plasma phosphorylated tau181: Early markers of Alzheimer's disease‐related declines. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring. 2021. doi:10.1002/dad2.12238.
BibTeX
@article{thomas2021-2dde0399,
author = {Thomas, Kelsey R. and Bangen, Katherine J. and Edmonds, Emily C. and Weigand, Alexandra J. and Walker, Kayla S. and Bondi, Mark W. and Galasko, Douglas R. and {Alzheimer's Disease Neuroimaging Initiative}},
title = {{Objective subtle cognitive decline and plasma phosphorylated tau181: Early markers of Alzheimer's disease‐related declines}},
journal = {Alzheimer's \& Dementia: Diagnosis, Assessment \& Disease Monitoring},
year = {2021},
doi = {10.1002/dad2.12238},
url = {https://doi.org/10.1002/dad2.12238}
}
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