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Blood Beta-Amyloid and Tau in Down Syndrome: A Comparison with Alzheimer's Disease
Lee NC, Yang SY, Chieh JJ, Huang PT, Chang LM, Chiu YN, Huang AC, Chien YH et al.. Frontiers in aging neuroscience, 2017-01-17
Topic: Amyloid, tau and blood-test diagnosis
The Aβ-40 and tau levels were higher and the Aβ-42 level and Aβ-42/Aβ-40 ratio were lower in DS than in the controls (all p < 0.001). Decreased Aβ-40 and increased Aβ-42 levels and Aβ-42/40 ratios were observed in DS_D compared with DS without degeneration (all p < 0.001). The ABDQ score was negatively correlated with the Aβ-40 level ( ρ = -0.556) and the tau protein level ( ρ = -0.410) and positively associated with the Aβ-42 level ( ρ = 0.621) and the Aβ-42/40 ratio ( ρ = 0.544; all p < 0.05). The Aβ-40 and Aβ-42 levels and the Aβ-42/Aβ-40 ratio are considered possible biomarkers for the early detection of degeneration in DS. The elevated Aβ-40 and tau levels in DS may indicate early neurodegeneration. The increased Aβ-42 in DS_D may reflect the neurotoxicity of Aβ-42. The paradox of the tau decreases in DS_D could be explained by a burnout phenomenon during long-term neurodegeneration. The different patterns of the plasma beta amyloids and tau protein may imply a different pathogenesis between DS with degeneration and AD in the general population, in spite of their common key pathological features.
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APA 7th
Lee, N. C., Yang, S. Y., Chieh, J. J., Huang, P. T., Chang, L. M., Chiu, Y. N., et al. (2016). Blood Beta-Amyloid and Tau in Down Syndrome: A Comparison with Alzheimer's Disease. Frontiers in aging neuroscience. https://doi.org/10.3389/fnagi.2016.00316
Vancouver
Lee NC, Yang SY, Chieh JJ, Huang PT, Chang LM, Chiu YN, et al. Blood Beta-Amyloid and Tau in Down Syndrome: A Comparison with Alzheimer's Disease. Frontiers in aging neuroscience. 2016. doi:10.3389/fnagi.2016.00316. PMID: 28144219.
BibTeX
@article{lee2016-28144219,
author = {Lee, N. C. and Yang, S. Y. and Chieh, J. J. and Huang, P. T. and Chang, L. M. and Chiu, Y. N. and Huang, A. C. and Chien, Y. H. and others},
title = {{Blood Beta-Amyloid and Tau in Down Syndrome: A Comparison with Alzheimer's Disease}},
journal = {Frontiers in aging neuroscience},
year = {2016},
doi = {10.3389/fnagi.2016.00316},
pmid = {28144219},
url = {https://doi.org/10.3389/fnagi.2016.00316}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.
Key findings
- The Aβ-40 and tau levels were higher and the Aβ-42 level and Aβ-42/Aβ-40 ratio were lower in DS than in the controls (all p < 0.001).
- Decreased Aβ-40 and increased Aβ-42 levels and Aβ-42/40 ratios were observed in DS_D compared with DS without degeneration (all p < 0.001).
- The ABDQ score was negatively correlated with the Aβ-40 level ( ρ = -0.556) and the tau protein level ( ρ = -0.410) and positively associated with the Aβ-42 level ( ρ = 0.621) and the Aβ-42/40 ratio ( ρ = 0.544; all p < 0.05).
- The Aβ-40 and Aβ-42 levels and the Aβ-42/Aβ-40 ratio are considered possible biomarkers for the early detection of degeneration in DS.
- The elevated Aβ-40 and tau levels in DS may indicate early neurodegeneration.
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Study details
- Participants62
- Evidence strengthLow
How this study scored 47/100
Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomized / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multicenter collaboration, so those were left out: it earned 27 of the 58 points we could judge it on, which is 47 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Frontiers in aging neuroscience) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2016 — within 20 year(s) of the newest study here |
| Sample size | 1 / 4 | 62 participants |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 3 / 3 | Studied in people (participant count stated) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multicenter collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 28144219) |
| Free to read | 2 / 2 | Free to read |
| Points | 27 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 27 of the 58 points we could judge it on is 47 out of 100. |
| Total | 47 / 100 | — |
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