down-syndrome

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1. 45/100

   Alzheimer's polygenic risk scores are associated with cognitive phenotypes in Down syndrome

   ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023-10-19 · Biomarkers

   These data indicate that the AD genetic architecture influences cognitive and CSF phenotypes in DS adults, supporting common pathways that influence memory decline in both traits.

   • Biomarkers
   • Genetics
   • Down Syndrome
2. 48/100

   Plasma biomarkers for amyloid, tau, and cytokines in Down syndrome and sporadic Alzheimer's disease

   ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Alzheimer's research & therapy · 2019-03-21 · Biomarkers

   Concentrations of Aβ 40 and Aβ 42 were much higher in adults with DS than in other groups, reflecting APP gene triplication, while no difference in the Aβ 42 /Aβ 40 ratio between those with DS and sAD may indicate similar processing and deposition of Aβ 40 and Aβ 42 in these groups.

   • Biomarkers
   • Down Syndrome
3. 38/100

   Plasma Neurofilament Light and Alzheimer's Disease Biomarkers in Down Syndrome: Results from the Down Syndrome Biomarker Initiative (DSBI)

   ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Journal of Alzheimer's disease : JAD · 2019-01-01 · Biomarkers

   Plasma NF-L is associated with progressive neurodegeneration as well as with declines in cognitive and functional measures in adults with DS.

   • Biomarkers
   • Down Syndrome
4. 47/100

   Blood Beta-Amyloid and Tau in Down Syndrome: A Comparison with Alzheimer's Disease

   ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Frontiers in aging neuroscience · 2017-01-17 · Biomarkers

   The Aβ-40 and tau levels were higher and the Aβ-42 level and Aβ-42/Aβ-40 ratio were lower in DS than in the controls (all p < 0.001).

   • Brain Biology
5. 36/100

   Candidate genes for Alzheimer's disease are associated with individual differences in plasma levels of beta amyloid peptides in adults with Down syndrome

   ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Neurobiology of aging · 2015-06-19 · Biomarkers

   We examined the contribution of candidates genes for Alzheimer's disease (AD) to individual differences in levels of beta amyloid peptides in adults with Down syndrom, a population at high risk for AD.

   • Genetics
   • Down Syndrome
6. 43/100

   Serum NGAL is Associated with Distinct Plasma Amyloid-β Peptides According to the Clinical Diagnosis of Dementia in Down Syndrome

   ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Journal of Alzheimer's disease : JAD · 2015-01-01 · Biomarkers

   Serum NGAL levels are increased in DS and associated with distinct species of Aβ depending on the progression of dementia as diagnosed by baseline and follow-up clinical assessments.

   • Biomarkers
   • Diagnosis
   • Genetics
7. 36/100

   Progressive myoclonus epilepsy in Down syndrome patients with dementia

   ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of neurology · 2014-06-04 · Biomarkers

   This study aimed to elucidate the natural history of senile myoclonic epilepsy, a type of myoclonic epilepsy associated with Alzheimer's disease in adult Down syndrome patients.

   • Biomarkers
   • Down Syndrome
   • Genetics
8. 36/100

   Decreased levels of synaptosomal associated protein 25 in the brain of patients with Down syndrome and Alzheimer's disease

   ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Electrophoresis · 1999-04-01 · Biomarkers

   Synaptosomal associated protein 25 kDa (snap-25) is a widely distributed membrane-associated protein in the brain, mainly localized in nerve terminals.

   • Down Syndrome

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