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48/100

✓ Peer-reviewed alzhub usefulness score 48 out of 100. Getting a diagnosis

Topic: Risk, prevention and care in population studies

Linear mixed modelling of time effects found progression of all CBI-R domains, aside from sleep, beliefs and mood domains, and all ACE-III domains. Modelling of group effects found that bvFTD had greater symptoms than AD in most CBI-R domains. Notably, SDL and SDR compared differently with AD and bvFTD; whilst SDR did not differ significantly from bvFTD in any CBI-R domain, SDL had less severe symptoms than bvFTD in everyday skills, motivation, sleep and eating habits; whilst SDL had greater disturbances in abnormal behaviour and stereotypic behaviour than AD, SDR had greater disturbances in addition in motivation and eating habits. Motivation, eating habits, abnormal behaviour and stereotypic behaviour were the most frequently different behavioural domains between groups. We have shown that the combined, longitudinal use of existing behavioural and cognitive assessments could capture distinct clinical profiles of common and rare dementia syndromes. Our findings also highlight the importance of select behavioural domains such as motivation and the usefulness of separate clinical characterisations of SDL and SDR.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Zhang, X., Irish, M., Piguet, O., & Ahmed, R. M. (2025). Behavioural and cognitive profiles in frontotemporal dementia and Alzheimer’s disease: a longitudinal study. Journal of Neurology. https://doi.org/10.1007/s00415-025-13025-z

Vancouver

Zhang X, Irish M, Piguet O, Ahmed RM. Behavioural and cognitive profiles in frontotemporal dementia and Alzheimer’s disease: a longitudinal study. Journal of Neurology. 2025. doi:10.1007/s00415-025-13025-z. PMID: 40116949.

BibTeX

@article{zhang2025-40116949,
  author  = {Zhang, Xin and Irish, Muireann and Piguet, Olivier and Ahmed, Rebekah M.},
  title   = {{Behavioural and cognitive profiles in frontotemporal dementia and Alzheimer’s disease: a longitudinal study}},
  journal = {Journal of Neurology},
  year    = {2025},
  doi     = {10.1007/s00415-025-13025-z},
  pmid    = {40116949},
  url     = {https://doi.org/10.1007/s00415-025-13025-z}
}

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Key findings

Linear mixed modelling of time effects found progression of all CBI-R domains, aside from sleep, beliefs and mood domains, and all ACE-III domains.
Modelling of group effects found that bvFTD had greater symptoms than AD in most CBI-R domains.
Notably, SDL and SDR compared differently with AD and bvFTD; whilst SDR did not differ significantly from bvFTD in any CBI-R domain, SDL had less severe symptoms than bvFTD in everyday skills, motivation, sleep and eating habits; whilst SDL had greater disturbances in abnormal behaviour and stereotypic behaviour than AD, SDR had greater disturbances in addition in motivation and eating habits.
Motivation, eating habits, abnormal behaviour and stereotypic behaviour were the most frequently different behavioural domains between groups.
We have shown that the combined, longitudinal use of existing behavioural and cognitive assessments could capture distinct clinical profiles of common and rare dementia syndromes.

Why it matters

This longitudinal study found that combined behavioural and cognitive assessments can capture distinct clinical profiles of frontotemporal dementia and Alzheimer's disease. It is about clinical characterisation, not treatment, cure, or prevention.

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Study details

Study designlongitudinal study
Evidence strengthModerate

How this study scored 48/100

Published in a peer-reviewed journal, and it is a longitudinal study following the same people over time. Scored zero for sample size, effect reported, studied in people and randomised / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Journal of Neurology)
Journal's citation record	2 / 4	Journal of Neurology: journal h-index 208 (OpenAlex, 2026-10-29)
Study design	7 / 12	A longitudinal study following the same people over time
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomised / blinded	0 / 2	No randomisation or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	1 / 7	Cited 3 times (OpenAlex, 2026-10-10)
Citations per year	1 / 5	1.0 citations a year over 3 year(s) since 2025
Impact for its field and year	2 / 6	Cited 1.9× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	1 / 4	Cited 3 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	2 / 4	Last-listed author Rebekah M. Ahmed: h-index 37 (OpenAlex, whole career)
Institution's track record	2 / 3	University College London: institution h-index 2,029 (OpenAlex)
Multi-centre collaboration	2 / 3	OpenAlex lists 4 institution(s) in 2 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 40116949)
Free to read	2 / 2	Free to read
Total	48 / 100	—

What each of these 20 components measures, and what this score is not →

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