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57/100

✓ Peer-reviewed alzhub usefulness score 57 out of 100. How common it is

Topic: Amyloid, tau and blood-test diagnosis

Plain-language summary

Bariatric surgery was associated with a significantly reduced incidence of ADRD, evidenced by a subdistribution hazard ratio (SHR) of 0.37 (95% confidence interval [CI]: 0.15–0.89; P = 0.03). Similarly, the incidence of MCI was significantly lower in the surgical group, with an SHR of 0.57 (95% CI: 0.39–0.85; P = 0.01). Additionally, patients who underwent bariatric surgery experienced a delay of 2.01 years before developing MCI compared with the control group (95% CI: 0.70–3.50; P = 0.004). These findings suggest that bariatric surgery may serve as an effective strategy to delay the onset of MCI and reduce the risk of both MCI and ADRD in patients with obesity.

What this study adds

Evidence grade: Moderate

This is a follow-up (cohort) study of 5,303 participants. In this retrospective cohort, bariatric surgery was associated with significantly reduced incidence of Alzheimer disease and related dementias and mild cognitive impairment, and with a delay of about two years before developing MCI. These findings suggest bariatric surgery may serve as an effective strategy to delay MCI onset and reduce dementia risk in patients with obesity.

Taken from this record’s own fields, not from reading the paper. The grade is assigned from the abstract’s wording; what that means.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Chen, Y., Feng, Y., Zhang, X., Gifford, K. A., ElManzalawi, Y., Samuels, J. M., et al. (2025). Bariatric Surgery Is Associated With Reduced Incidence of Mild Cognitive Impairment and Alzheimer Disease and Related Dementias: A Retrospective Cohort Study. Annals of Surgery Open. https://doi.org/10.1097/as9.0000000000000541

Vancouver

Chen Y, Feng Y, Zhang X, Gifford KA, ElManzalawi Y, Samuels JM, et al. Bariatric Surgery Is Associated With Reduced Incidence of Mild Cognitive Impairment and Alzheimer Disease and Related Dementias: A Retrospective Cohort Study. Annals of Surgery Open. 2025. doi:10.1097/as9.0000000000000541. PMID: 40134493.

BibTeX

@article{chen2025-40134493,
  author  = {Chen, You and Feng, Yubo and Zhang, Xinmeng and Gifford, Katherine A. and ElManzalawi, Yasser and Samuels, Jason M. and Albaugh, Vance L. and English, Wayne J. and others},
  title   = {{Bariatric Surgery Is Associated With Reduced Incidence of Mild Cognitive Impairment and Alzheimer Disease and Related Dementias: A Retrospective Cohort Study}},
  journal = {Annals of Surgery Open},
  year    = {2025},
  doi     = {10.1097/as9.0000000000000541},
  pmid    = {40134493},
  url     = {https://doi.org/10.1097/as9.0000000000000541}
}

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record's author list ends in “et al.”, so not every author is named. Check the citation against the original before you use it.

How to read this study

Design: this is a follow-up (cohort) study. People are observed over time and not assigned to anything, so an association can reflect other differences between groups. Look at how long follow-up lasted, how many dropped out, and whether the authors adjusted for age, education and other health conditions.
Size: the record lists 5,303 participants. Ask whether that is enough for the question, and who they were.
Effect: the record gives no effect size, so the summary above cannot say how large any difference was.

What the evidence grade means here

This page is graded moderate. alzhub.org assigns the grade automatically from keywords in the abstract, not from reading the paper. Moderate means the abstract mentions a cohort, case-control or longitudinal design. It can add at most 5 of the 100 points in the study score, and it is a label about design, not a verdict on whether the findings are true.

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Key findings

Bariatric surgery was associated with a significantly reduced incidence of ADRD, evidenced by a subdistribution hazard ratio (SHR) of 0.37 (95% confidence interval [CI]: 0.15–0.89; P = 0.03).
Similarly, the incidence of MCI was significantly lower in the surgical group, with an SHR of 0.57 (95% CI: 0.39–0.85; P = 0.01).
Additionally, patients who underwent bariatric surgery experienced a delay of 2.01 years before developing MCI compared with the control group (95% CI: 0.70–3.50; P = 0.004).
These findings suggest that bariatric surgery may serve as an effective strategy to delay the onset of MCI and reduce the risk of both MCI and ADRD in patients with obesity.

Why it matters

In this retrospective cohort, bariatric surgery was associated with significantly reduced incidence of Alzheimer disease and related dementias and mild cognitive impairment, and with a delay of about two years before developing MCI. These findings suggest bariatric surgery may serve as an effective strategy to delay MCI onset and reduce dementia risk in patients with obesity.

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Study details

Study designlongitudinal study
Participants5,303
Evidence strengthModerate

How this study scored 57/100

Published in a peer-reviewed journal, and it is a longitudinal study following the same people over time. Scored zero for effect reported and randomized / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Annals of Surgery Open)
Journal's citation record	0 / 4	Annals of Surgery Open: journal h-index 26 (OpenAlex, 2026-10-29)
Study design	7 / 12	A longitudinal study following the same people over time
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	4 / 5	2025 — within 3 year(s) of the newest study here
Sample size	3 / 4	5,303 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomized / blinded	0 / 2	No randomization or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	2 / 7	Cited 9 times (OpenAlex, 2026-10-10)
Citations per year	2 / 5	3.0 citations a year over 3 year(s) since 2025
Impact for its field and year	4 / 6	Cited 8.0× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	0 / 6	No other study in this library cites it
Still being cited	1 / 4	Cited 9 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	3 / 4	Last-listed author Sayeed Ikramuddin: h-index 57 (OpenAlex, whole career)
Institution's track record	2 / 3	University of Minnesota: institution h-index 1,568 (OpenAlex)
Multicenter collaboration	2 / 3	OpenAlex lists 6 institution(s) in 1 country
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 40134493)
Free to read	2 / 2	Free to read
Total	57 / 100	—

What each of these 20 components measures, and what this score is not →

Read the original

Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

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