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55/100

✓ Peer-reviewed alzhub usefulness score 55 out of 100. Mild cognitive impairment

Topic: Amyloid, tau and blood-test diagnosis

The speed and severity of clinical progression after Alzheimer disease (AD) diagnosis varies and depends on multiple factors, most not well elucidated. We assessed whether body mass index (BMI) and 1-year weight change (WC) are associated with clinical progression in amnestic mild cognitive impairment (aMCI) and early-stage AD. Longitudinal data comprising 2268 aMCI and 1506 AD participants in the National Alzheimer's Coordinating Center's Uniform Data Set were used to examine nuances of clinical progression by BMI and WC, as well as potential variations in associations by age, sex, BMI (WC model), or apolipoprotein E genotype. In aMCI, high BMI (vs. moderate BMI) was associated with slower progression; weight loss (vs. no WC) was associated with faster progression. In AD, no significant differences were observed in clinical progression by BMI or WC. The association between BMI and clinical progression varied significantly by apolipoprotein E genotype in AD, and the association between WC and clinical progression varied significantly by sex and BMI in aMCI. Baseline BMI and 1-year WC in late life may serve as early prognostic indicators in aMCI and early-stage AD. If replicated, these results may help in counseling patients on anticipated clinical progression and suggest windows of opportunity for intervention.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Besser, L. M., Gill, D. P., Monsell, S. E., Brenowitz, W., Meranus, D. H., Kukull, W., et al. (2014). Body mass index, weight change, and clinical progression in mild cognitive impairment and Alzheimer disease. Alzheimer disease and associated disorders. https://doi.org/10.1097/wad.0000000000000005

Vancouver

Besser LM, Gill DP, Monsell SE, Brenowitz W, Meranus DH, Kukull W, et al. Body mass index, weight change, and clinical progression in mild cognitive impairment and Alzheimer disease. Alzheimer disease and associated disorders. 2014. doi:10.1097/wad.0000000000000005. PMID: 24126214.

BibTeX

@article{besser2014-24126214,
  author  = {Besser, L. M. and Gill, D. P. and Monsell, S. E. and Brenowitz, W. and Meranus, D. H. and Kukull, W. and Gustafson, D. R.},
  title   = {{Body mass index, weight change, and clinical progression in mild cognitive impairment and Alzheimer disease}},
  journal = {Alzheimer disease and associated disorders},
  year    = {2014},
  doi     = {10.1097/wad.0000000000000005},
  pmid    = {24126214},
  url     = {https://doi.org/10.1097/wad.0000000000000005}
}

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.

Key findings

We assessed whether body mass index (BMI) and 1-year weight change (WC) are associated with clinical progression in amnestic mild cognitive impairment (aMCI) and early-stage AD.
In aMCI, high BMI (vs. moderate BMI) was associated with slower progression; weight loss (vs. no WC) was associated with faster progression.
In AD, no significant differences were observed in clinical progression by BMI or WC.
The association between BMI and clinical progression varied significantly by apolipoprotein E genotype in AD, and the association between WC and clinical progression varied significantly by sex and BMI in aMCI.
If replicated, these results may help in counseling patients on anticipated clinical progression and suggest windows of opportunity for intervention.

Why it matters

In amnestic mild cognitive impairment, high body mass index was associated with slower progression and weight loss with faster progression, while in Alzheimer's disease no significant differences were seen by BMI or weight change. These findings suggest BMI and weight change may serve as early prognostic indicators, but they do not show that changing weight alters the disease.

Study details

Study designlongitudinal study
Evidence strengthModerate

How this study scored 55/100

Published in a peer-reviewed journal, and it is a longitudinal study following the same people over time. Scored zero for sample size, effect reported, studied in people and randomized / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (Alzheimer disease and associated disorders)
Journal's citation record	1 / 4	Alzheimer Disease & Associated Disorders: journal h-index 131 (OpenAlex, 2026-10-29)
Study design	7 / 12	A longitudinal study following the same people over time
Strength of evidence	3 / 5	Rated “moderate” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	1 / 5	2014 — within 20 year(s) of the newest study here
Sample size	0 / 4	Participant count not stated — scores zero (not stated in the record — scored 0)
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	0 / 3	Not stated whether this was studied in people — scores zero (not stated in the record — scored 0)
Randomized / blinded	0 / 2	No randomization or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	5 / 7	Cited 150 times (OpenAlex, 2026-10-10)
Citations per year	3 / 5	10.7 citations a year over 14 year(s) since 2014
Impact for its field and year	4 / 6	Cited 8.1× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	2 / 6	Cited by 6 other studies in this library
Still being cited	2 / 4	Cited 21 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	3 / 4	Last-listed author Deborah Gustafson: h-index 59 (OpenAlex, whole career)
Institution's track record	3 / 3	University of Washington: institution h-index 3,540 (OpenAlex)
Multicenter collaboration	2 / 3	OpenAlex lists 7 institution(s) in 3 countries
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 24126214)
Free to read	0 / 2	Behind a paywall — scores zero
Total	55 / 100	—

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