This page is alzhub.org's plain-English summary of a published study, not the paper itself. It is generated from the record we hold for this study, sourced and linked below — check the original for the full text and methods.

47/100

✓ Peer-reviewed alzhub usefulness score 47 out of 100. Long-term cohort studies

Topic: Amyloid, tau and blood-test diagnosis

We examined differences in cerebral blood flow (CBF) measured by Arterial Spin Labeled perfusion MRI (ASL MRI) across the continuum from cognitively normal (CN) older adults to mild Alzheimer's Disease (AD) using data from the multi-site Alzheimer's Disease Neuroimaging Initiative (ADNI). Measures of CBF, in a predetermined set of regions (meta-ROI), and hippocampal volume were compared between CN (n = 47), patients with early and late Mild Cognitive Impairment [EMCI (n = 32), LMCI (n = 35)], and AD (n = 15). Associations between these measures and disease severity, assessed by Clinical Dementia Rating scale sum of boxes (CDR SB), were also assessed.

Cite this study APA, Vancouver, BibTeX · download .bib or .ris

APA 7th

Wang, Z., Das, SR., Xie, S. X., Arnold, S. E., Detre, J. A., Wolk, D. A., et al. (2013). Arterial spin labeled MRI in prodromal Alzheimer's disease: A multi-site study. NeuroImage. Clinical. https://doi.org/10.1016/j.nicl.2013.04.014

Vancouver

Wang Z, Das SR, Xie SX, Arnold SE, Detre JA, Wolk DA, et al. Arterial spin labeled MRI in prodromal Alzheimer's disease: A multi-site study. NeuroImage. Clinical. 2013. doi:10.1016/j.nicl.2013.04.014. PMID: 24179814.

BibTeX

@article{wang2013-24179814,
  author  = {Wang, Z. and Das, SR. and Xie, S. X. and Arnold, S. E. and Detre, J. A. and Wolk, D. A. and {Alzheimer's Disease Neuroimaging Initiative}},
  title   = {{Arterial spin labeled MRI in prodromal Alzheimer's disease: A multi-site study}},
  journal = {NeuroImage. Clinical},
  year    = {2013},
  doi     = {10.1016/j.nicl.2013.04.014},
  pmid    = {24179814},
  url     = {https://doi.org/10.1016/j.nicl.2013.04.014}
}

Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. The record names 7 authors; APA and Vancouver show the first six, BibTeX and the downloads carry all of them. Check the citation against the original before you use it.

Key findings

Measures of CBF, in a predetermined set of regions (meta-ROI), and hippocampal volume were compared between CN (n = 47), patients with early and late Mild Cognitive Impairment [EMCI (n = 32), LMCI (n = 35)], and AD (n = 15).
Associations between these measures and disease severity, assessed by Clinical Dementia Rating scale sum of boxes (CDR SB), were also assessed.
Mean meta-ROI CBF was associated with group status and significant hypoperfusion was observed in LMCI and AD relative to CN.
Hippocampal volume was associated with group status, but only AD patients had significantly smaller volumes than the CN.

Why it matters

Using arterial spin labeled MRI, this multi-site study found lower cerebral blood flow in late mild cognitive impairment and Alzheimer's disease compared with cognitively normal older adults. It is an imaging study of blood flow and does not test any treatment, cure, or prevention.

Study details

Participants47
Evidence strengthLow

How this study scored 47/100

Published in a peer-reviewed journal. Scored zero for study design, effect reported and randomized / blinded because the record does not state it.

Component	Points	Why
Journal tier	7 / 10	Tier 3 — peer-reviewed journal (NeuroImage. Clinical)
Journal's citation record	1 / 4	NeuroImage Clinical: journal h-index 133 (OpenAlex, 2026-10-29)
Study design	0 / 12	No study design recorded — scores zero, not guessed (not stated in the record — scored 0)
Strength of evidence	1 / 5	Rated “low” in our summary
Peer-review validation	10 / 10	Peer-reviewed. Published as an article in a named peer-reviewed journal.
How recent	1 / 5	2013 — within 20 year(s) of the newest study here
Sample size	1 / 4	47 participants
Effect reported	0 / 3	No effect size reported — scores zero (not stated in the record — scored 0)
Studied in people	3 / 3	Studied in people (participant count stated)
Randomized / blinded	0 / 2	No randomization or blinding stated — scores zero (not stated in the record — scored 0)
Times cited	5 / 7	Cited 105 times (OpenAlex, 2026-10-10)
Citations per year	2 / 5	7.0 citations a year over 15 year(s) since 2013
Impact for its field and year	3 / 6	Cited 6.0× the average for papers of its field and year (OpenAlex FWCI)
Cited by studies here	2 / 6	Cited by 3 other studies in this library
Still being cited	2 / 4	Cited 25 times in 2024–2026 (2026 still in progress; OpenAlex)
Senior author's track record	3 / 4	Last-listed author David A. Wolk: h-index 96 (OpenAlex, whole career)
Institution's track record	2 / 3	University of Pennsylvania: institution h-index 1,859 (OpenAlex)
Multicenter collaboration	0 / 3	OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete)
Indexed in PubMed	2 / 2	Indexed in PubMed (PMID 24179814)
Free to read	2 / 2	Free to read
Total	47 / 100	—

What each of these 20 components measures, and what this score is not →

Read the original

Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).

Studies in the library that share something with this one. The line above each title says what.

Studies this one cites

Referenced by this study and also in the alzhub library, so you can read them here. Showing 12 of 23.

Later studies that cite this one

3 studies in the alzhub library list this one in their references.

Related studies in Long-term cohort studies

Also tagged “machine”

834 studies in the library carry the topic tag “machine”; these are this study's neighbours in a fixed, alphabetical-by-hash tour of them, not the closest in content. All 834 tagged studies.

Studies sharing this one's topic tags

Similar studies

More on Long-term cohort studies

See all studies in Long-term cohort studies →