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Androgens Prevent the Heat Shock-Induced Hyperphosphorylation but not Dephosphorylation of t in Female Rats. Implications for Alzheimer's Disease
Papasozomenos SC, Papasozomenos T.. Journal of Alzheimer's disease : JAD, 1999-10-01
Topic: Brain proteins, microglia and lab models
We have previously shown that heat shock induces rapid dephosphorylation of tau in both female and male rats followed by hyperphosphorylation only in female rats (J Neurochem 66 (1996), 1140-1149). We have also shown that the heat shock-induced hyperphos-phorylation of tau is estrogen-independent in female rats and prevented by androgens in male rats (Proc Natl Acad Sci USA 94 (1997), 6612-6617). To investigate whether androgens could prevent the hyperphosphorylation of tau also in female rats, twenty-three 2- to 3-month-old Sprague-Dawley rats were ovariectomized and given daily subcutaneous injections of 1 mg/250 g of testosterone propionate for 3-5 weeks. Immunoblots of SDS cerebral extracts were analysed qualitatively using the peroxidase-antiperoxidase technique and phosphate-dependent and -independent anti-tau antibodies, and quantitatively using Tau-1 and 125I-labeled protein A. We have found that while at 0 h after heat shock tau was dephosphorylated, at 3 h and 6 h after heat shock tau was not hyperphosphorylated, as would be the case in non-androgen-treated female rats (ref. above). In addition, tau became dephosphorylated in non-heat-shocked control rats. Because tau is abnormally hyperphosphorylated in Alzheimer's disease, the possibility of using combined estrogen/androgen replacement therapy in postmenopausal women as a preventive measure against Alzheimer's disease should be investigated.
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APA 7th
Papasozomenos, S. C., & Papasozomenos, T. (1999). Androgens Prevent the Heat Shock-Induced Hyperphosphorylation but not Dephosphorylation of t in Female Rats. Implications for Alzheimer's Disease. Journal of Alzheimer's disease : JAD. https://doi.org/10.3233/jad-1999-1302
Vancouver
Papasozomenos SC, Papasozomenos T. Androgens Prevent the Heat Shock-Induced Hyperphosphorylation but not Dephosphorylation of t in Female Rats. Implications for Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 1999. doi:10.3233/jad-1999-1302. PMID: 12214000.
BibTeX
@article{papasozomenos1999-12214000,
author = {Papasozomenos, S. C. and Papasozomenos, T.},
title = {{Androgens Prevent the Heat Shock-Induced Hyperphosphorylation but not Dephosphorylation of t in Female Rats. Implications for Alzheimer's Disease}},
journal = {Journal of Alzheimer's disease : JAD},
year = {1999},
doi = {10.3233/jad-1999-1302},
pmid = {12214000},
url = {https://doi.org/10.3233/jad-1999-1302}
}
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Key findings
- We have previously shown that heat shock induces rapid dephosphorylation of tau in both female and male rats followed by hyperphosphorylation only in female rats (J Neurochem 66 (1996), 1140-1149).
- We have also shown that the heat shock-induced hyperphos-phorylation of tau is estrogen-independent in female rats and prevented by androgens in male rats (Proc Natl Acad Sci USA 94 (1997), 6612-6617).
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Study details
- Evidence strengthLow
How this study scored 36/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported and randomised / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multi-centre collaboration, so those were left out: it earned 21 of the 58 points we could judge it on, which is 36 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of Alzheimer's disease : JAD) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 1999 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Laboratory or animal study (title names “rats”) — scores zero |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 12214000) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 21 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 21 of the 58 points we could judge it on is 36 out of 100. |
| Total | 36 / 100 | — |
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