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Absence of abnormal hyperphosphorylation of tau in intracellular tangles in Alzheimer's disease
Bondareff W, Harrington CR, Wischik CM, Hauser DL, Roth M.. Journal of neuropathology and experimental neurology, 1995-09-01
Topic: Brain proteins, microglia and lab models
Plain-language summary
Adult human nerve cells contain tau protein, a phosphorylated microtubule-associated protein, that is hyperphosphorylated in the fetus and in patients with Alzheimer's disease. Hyperphosphorylation, which diminishes the microtubule-binding capacity of tau, destabilizes microtubules and may enhance the formation of paired helical filaments that constitute neurofibrillary tangles in Alzheimer's disease. Here, we use phosphorylation-dependent anti-tau antibodies to detect specific epitopes that characterize hyperphosphorylated tau. Our demonstration of intracellular tangles containing full-length tau that are not immunolabeled by these antibodies suggests that hyperphosphorylation of tau is not obligatory in the formation of neurofibrillary tangles in Alzheimer's disease.
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APA 7th
Bondareff, W., Harrington, C. R., Wischik, C. M., Hauser, D. L., & Roth, M. (1995). Absence of abnormal hyperphosphorylation of tau in intracellular tangles in Alzheimer's disease. Journal of neuropathology and experimental neurology. https://doi.org/10.1097/00005072-199509000-00007
Vancouver
Bondareff W, Harrington CR, Wischik CM, Hauser DL, Roth M. Absence of abnormal hyperphosphorylation of tau in intracellular tangles in Alzheimer's disease. Journal of neuropathology and experimental neurology. 1995. doi:10.1097/00005072-199509000-00007. PMID: 7666054.
BibTeX
@article{bondareff1995-7666054,
author = {Bondareff, W. and Harrington, C. R. and Wischik, C. M. and Hauser, D. L. and Roth, M.},
title = {{Absence of abnormal hyperphosphorylation of tau in intracellular tangles in Alzheimer's disease}},
journal = {Journal of neuropathology and experimental neurology},
year = {1995},
doi = {10.1097/00005072-199509000-00007},
pmid = {7666054},
url = {https://doi.org/10.1097/00005072-199509000-00007}
}
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Key findings
- Our demonstration of intracellular tangles containing full-length tau that are not immunolabeled by these antibodies suggests that hyperphosphorylation of tau is not obligatory in the formation of neurofibrillary tangles in Alzheimer's disease.
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Study details
- Evidence strengthLow
How this study scored 36/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it. We have no data on journal's citation record, times cited, citations per year, impact for its field and year, cited by studies here, still being cited, senior author's track record, institution's track record and multicenter collaboration, so those were left out: it earned 21 of the 58 points we could judge it on, which is 36 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Journal of neuropathology and experimental neurology) |
| Journal's citation record | — / 4 | No journal record from OpenAlex — left out of this score |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 1995 — older than 20 years, still counted |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | — / 7 | No citation count (not found in OpenAlex) — left out of this score |
| Citations per year | — / 5 | No citation count or no year — left out of this score |
| Impact for its field and year | — / 6 | No field-weighted citation impact (OpenAlex has none yet) — left out of this score |
| Cited by studies here | — / 6 | Not yet checked against this library's citation graph — left out of this score |
| Still being cited | — / 4 | No yearly citation counts — left out of this score |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multicenter collaboration | — / 3 | Institutions not listed — left out of this score |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 7666054) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 21 / 58 | Scored on 11 of 20 parts. We have no data for the rest, so they are left out: 21 of the 58 points we could judge it on is 36 out of 100. |
| Total | 36 / 100 | — |
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