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Alzheimer-Krankheit: Wert prädiktiver Blut-Biomarker untersucht
Fortschritte der Neurologie · Psychiatrie, 2025-12-01
Topic: Amyloid, tau and blood-test diagnosis
Als blutbasierter Biomarker zur Diagnose der Alzheimer-Krankheit gilt p-Tau217. Die Bedeutung einer detaillierten kognitiven Phänotypisierung bei Patienten ohne Demenz ist für die Interpretation der p-Tau217-Ergebnisse nicht eindeutig. Daher untersuchten die MEMENTO und BALTAZAR Studien, ob die Genauigkeit und die prädiktiven Werte anhand von p-Tau217 im Blut zwischen den kognitiven Phänotypen variieren. Publication History Article published online: 02 December 2025 © 2025. Thieme. All rights reserved. Georg Thieme Verlag KG Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany
Key findings
- Als blutbasierter Biomarker zur Diagnose der Alzheimer-Krankheit gilt p-Tau217.
- Die Bedeutung einer detaillierten kognitiven Phänotypisierung bei Patienten ohne Demenz ist für die Interpretation der p-Tau217-Ergebnisse nicht eindeutig.
- Daher untersuchten die MEMENTO und BALTAZAR Studien, ob die Genauigkeit und die prädiktiven Werte anhand von p-Tau217 im Blut zwischen den kognitiven Phänotypen variieren.
- Publication History Article published online: 02 December 2025 © 2025.
- Georg Thieme Verlag KG Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany
Why it matters
The MEMENTO and BALTAZAR studies examined whether the accuracy and predictive value of blood p-tau217 vary between cognitive phenotypes in patients without dementia. This is about interpreting a diagnostic biomarker, not about treating, curing, or preventing Alzheimer's disease.
New to this subject? Start with our plain-English guide: Blood tests & biomarkers →
Study details
- Evidence strengthLow
How this study scored 25/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it. We have no data on senior author's track record and institution's track record, so those were left out: it earned 23 of the 93 points we could judge it on, which is 25 out of 100.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Fortschritte der Neurologie · Psychiatrie) |
| Journal's citation record | 0 / 4 | Fortschritte der Neurologie · Psychiatrie: journal h-index 48 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 4 / 5 | 2025 — within 3 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 0 / 7 | Cited 0 times (OpenAlex, 2026-10-10) |
| Citations per year | 0 / 5 | 0.0 citations a year over 3 year(s) since 2025 |
| Impact for its field and year | 0 / 6 | Cited 0.0× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 0 / 6 | No other study in this library cites it |
| Still being cited | 0 / 4 | Cited 0 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | — / 4 | Senior author's record not available — left out of this score |
| Institution's track record | — / 3 | No institution listed in OpenAlex — left out of this score |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 0 institution(s) in 0 countries — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 1 / 2 | Not in PubMed, but has a DOI |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Points | 23 / 93 | Scored on 18 of 20 parts. We have no data for the rest, so they are left out: 23 of the 93 points we could judge it on is 25 out of 100. |
| Total | 25 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
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Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. This record has no authors, so the citation leaves them out. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Alzheimer-Krankheit: Wert prädiktiver Blut-Biomarker untersucht. (2025). Fortschritte der Neurologie · Psychiatrie. https://doi.org/10.1055/a-2700-8954
Vancouver
Alzheimer-Krankheit: Wert prädiktiver Blut-Biomarker untersucht. Fortschritte der Neurologie · Psychiatrie. 2025. doi:10.1055/a-2700-8954.
BibTeX
@article{study2025-f4256268,
title = {{Alzheimer-Krankheit: Wert prädiktiver Blut-Biomarker untersucht}},
journal = {Fortschritte der Neurologie · Psychiatrie},
year = {2025},
doi = {10.1055/a-2700-8954},
url = {https://doi.org/10.1055/a-2700-8954}
}
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