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Actin dynamics and cofilin-actin rods in alzheimer disease
Bamburg JR, Bernstein BW.. Cytoskeleton (Hoboken, N.J.), 2016-03-01
Topic: Amyloid, tau and blood-test diagnosis
Plain-language summary
Cytoskeletal abnormalities and synaptic loss, typical of both familial and sporadic Alzheimer disease (AD), are induced by diverse stresses such as neuroinflammation, oxidative stress, and energetic stress, each of which may be initiated or enhanced by proinflammatory cytokines or amyloid-β (Aβ) peptides. Extracellular Aβ-containing plaques and intracellular phospho-tau-containing neurofibrillary tangles are postmortem pathologies required to confirm AD and have been the focus of most studies. However, AD brain, but not normal brain, also have increased levels of cytoplasmic rod-shaped bundles of filaments composed of ADF/cofilin-actin in a 1:1 complex (rods).
What this study adds
Evidence grade: Low
This is a narrative review. This review describes cofilin-actin rods, rod-shaped filament bundles found in Alzheimer's disease brain but not normal brain, and how they relate to cytoskeletal abnormalities and synaptic loss. It is a summary of existing research and reports no new treatment, cure or prevention.
Taken from this record’s own fields, not from reading the paper. The grade is assigned from the abstract’s wording; what that means.
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
APA 7th
Bamburg, JR., & Bernstein, B. W. (2016). Actin dynamics and cofilin-actin rods in alzheimer disease. Cytoskeleton (Hoboken, N.J.). https://doi.org/10.1002/cm.21282
Vancouver
Bamburg JR, Bernstein BW. Actin dynamics and cofilin-actin rods in alzheimer disease. Cytoskeleton (Hoboken, N.J.). 2016. doi:10.1002/cm.21282. PMID: 26873625.
BibTeX
@article{bamburg2016-26873625,
author = {Bamburg, JR. and Bernstein, B. W.},
title = {{Actin dynamics and cofilin-actin rods in alzheimer disease}},
journal = {Cytoskeleton (Hoboken, N.J.)},
year = {2016},
doi = {10.1002/cm.21282},
pmid = {26873625},
url = {https://doi.org/10.1002/cm.21282}
}
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
Key findings
- Extracellular Aβ-containing plaques and intracellular phospho-tau-containing neurofibrillary tangles are postmortem pathologies required to confirm AD and have been the focus of most studies.
- However, AD brain, but not normal brain, also have increased levels of cytoplasmic rod-shaped bundles of filaments composed of ADF/cofilin-actin in a 1:1 complex (rods).
- Cofilin, the major ADF/cofilin isoform in mammalian neurons, severs actin filaments at low cofilin/actin ratios and stabilizes filaments at high cofilin/actin ratios.
- It binds cooperatively to ADP-actin subunits in F-actin.
Why it matters
This review describes cofilin-actin rods, rod-shaped filament bundles found in Alzheimer's disease brain but not normal brain, and how they relate to cytoskeletal abnormalities and synaptic loss. It is a summary of existing research and reports no new treatment, cure or prevention.
Study details
- Evidence strengthLow
How this study scored 39/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomized / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Cytoskeleton (Hoboken, N.J.)) |
| Journal's citation record | 0 / 4 | Cytoskeleton: journal h-index 68 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2016 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomized / blinded | 0 / 2 | No randomization or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 5 / 7 | Cited 179 times (OpenAlex, 2026-10-10) |
| Citations per year | 3 / 5 | 14.9 citations a year over 12 year(s) since 2016 |
| Impact for its field and year | 4 / 6 | Cited 12.1× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 1 / 6 | Cited by 2 other studies in this library |
| Still being cited | 3 / 4 | Cited 54 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 1 / 4 | Last-listed author Barbara W. Bernstein: h-index 16 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | Colorado State University: institution h-index 839 (OpenAlex) |
| Multicenter collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 26873625) |
| Free to read | 0 / 2 | Behind a paywall — scores zero |
| Total | 39 / 100 | — |
What each of these 20 components measures, and what this score is not →
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