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Newest in this topic

  1. Pathway-specific polygenic risk scores reveal underlying mechanisms of cerebral small vessel disease 2026-09-14
  2. Cerebral Small Vessel Disease and Risk of Cardiovascular Events and All-Cause Mortality: The Framingham Heart Study 2026-09-07
  3. Regional Distribution of Mineralized Blood Vessels in Alzheimer Disease and Clinicopathological Associations: A Multicenter Autopsy Study 2026-09-01

Studies

908 studies carry this tag.

Date range

1975 to 2026

Top journals

  • Neurology 93
  • Stroke 61
  • Alzheimer s & Dementia 31
  • Brain : a journal of neurology 20
  • Annals of neurology 19

343 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. Genome-wide association studies of cerebral white matter lesion burden: the CHARGE consortium

    ✓ Peer-reviewed alzhub usefulness score 75 out of 100. Annals of neurology 2011-06-01 Caregiving

    This large GWAS of WMH burden in community-based cohorts of individuals of European descent identifies a novel locus on chromosome 17.

  2. Identification of pure subcortical vascular dementia using 11C-Pittsburgh compound B

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Neurology 2011-05-18 Brain scans and imaging

    SVaD without abnormal amyloid imaging was more common than expected.

  3. Hypothesis for the pathophysiology of delirium: role of baseline brain network connectivity and changes in inhibitory tone

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Medical hypotheses 2011-04-16 Clinical safety

    Normal brain function is facilitated by a highly organized and interconnected structure allowing complex integration of sensory information and motor responses.

  4. Matrix metalloproteinases are associated with increased blood-brain barrier opening in vascular cognitive impairment

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Stroke 2011-03-31 Inflammation and the immune system

    Our results support the hypothesis that MMPs are associated with increased CSF albumin and suggest that they may contribute to the pathophysiology of SIVD.

  5. Surface-based TBM boosts power to detect disease effects on the brain: an N=804 ADNI study

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. NeuroImage 2011-03-23 Mild cognitive impairment

    Computational anatomy methods are now widely used in clinical neuroimaging to map the profile of disease effects on the brain and its clinical correlates.

  6. Prevalence of stroke and related burden among older people living in Latin America, India and China

    ✓ Peer-reviewed alzhub usefulness score 58 out of 100. Journal of neurology, neurosurgery, and psychiatry 2011-03-14 Disparities

    The prevalence of stroke in urban LA and Chinese sites is nearly as high as in industrialised countries.

  7. Mediterranean diet and magnetic resonance imaging-assessed cerebrovascular disease

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Annals of neurology 2011-02-01 Prevention trials

    Higher adherence to the MeDi is associated with reduced cerebrovascular disease burden.

  8. Review: cerebral microvascular pathology in ageing and neurodegeneration

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Neuropathology and applied neurobiology 2011-02-01 Lewy body dementia

    This review of age-related brain microvascular pathologies focuses on topics studied by this laboratory, including anatomy of the blood supply, tortuous vessels, venous collagenosis, capillary remnants, vascular density and microembolic brain injury.

  9. Review: sporadic cerebral amyloid angiopathy

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Neuropathology and applied neurobiology 2011-02-01 Getting a diagnosis

    Cerebral amyloid angiopathy (CAA) may result from focal to widespread amyloid-β protein (Aβ) deposition within leptomeningeal and intracortical cerebral blood vessels.

  10. Chronic traumatic encephalopathy: a potential late effect of sport-related concussive and subconcussive head trauma

    ✓ Peer-reviewed alzhub usefulness score 49 out of 100. Clinics in sports medicine 2011-01-01 Getting a diagnosis

    Chronic traumatic encephalopathy (CTE) is a form of neurodegeneration believed to result from repeated head injuries.

  11. Role of iron in brain injury after intraventricular hemorrhage

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Stroke 2010-12-16 Hippocampus size on brain scans

    Iron has a role in brain injury after IVH.

  12. Loss of white matter integrity is associated with gait disorders in cerebral small vessel disease

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Brain : a journal of neurology 2010-12-14 Vascular contributions

    Pathological studies have demonstrated abnormalities in white matter that may appear normal on brain imaging.

  13. Cerebral microbleeds, retinopathy, and dementia: the AGES-Reykjavik Study

    ✓ Peer-reviewed alzhub usefulness score 60 out of 100. Neurology 2010-12-01 Digital health tools

    Having multiple CMBs or concomitant CMBs and retinopathy is associated with a profile of vascular cognitive impairment.

  14. HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study

    ✓ Peer-reviewed alzhub usefulness score 64 out of 100. Neurology 2010-12-01 Getting a diagnosis

    The most severe HAND diagnosis (HAD) was rare, but milder forms of impairment remained common, even among those receiving CART who had minimal comorbidities.

  15. Immunohistochemical characterization of microglia in Nasu-Hakola disease brains

    ✓ Peer-reviewed alzhub usefulness score 37 out of 100. Neuropathology : official journal of the Japanese Society of Neuropathology 2010-12-01 TREM2 and immune genetics

    Nasu-Hakola disease (NHD) is a rare autosomal recessive disorder, characterized by progressive presenile dementia and formation of multifocal bone cysts, caused by genetic mutations of DNAX-activation protein 12 (DAP12) or triggering receptor expressed on myeloid cells 2 (TREM2).

  16. Increased brain atrophy rates in cognitively normal older adults with low cerebrospinal fluid Aβ1-42

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Annals of neurology 2010-12-01 Genetics

    Forty of 105 (38%) were classified as NC-low, and 65 (62%) as NC-high.

  17. Vascular basis for brain degeneration: faltering controls and risk factors for dementia

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. Nutrition reviews 2010-12-01 Prevention and risk

    The integrity of the vascular system is essential for the efficient functioning of the brain.

  18. Cerebral amyloid angiopathy pathology and cognitive domains in older persons

    ✓ Peer-reviewed alzhub usefulness score 68 out of 100. Annals of neurology 2010-11-08 Brain tissue and pathology

    Subjects were 404 persons in the Religious Orders Study, a cohort study of aging, who underwent annual clinical evaluations, including 19 neuropsychological tests from which 5 cognitive domain and global summary scores were derived, and brain autopsy at time-of-death (mean age-at-death 86).

  19. Frontal lobe white matter hyperintensities and neurofibrillary pathology in the oldest old

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. Neurology 2010-11-03 Brain scans and imaging

    Our study showed an association between neurofibrillary pathology and frontal PVWMH and DWMH (rather than parietal), as a surrogate of small vessel disease, particularly in very old community-dwelling individuals.

  20. Imaging correlates of pathology in corticobasal syndrome

    ✓ Peer-reviewed alzhub usefulness score 61 out of 100. Neurology 2010-11-01 Brain scans and imaging

    Imaging patterns of atrophy in CBS vary according to pathologic diagnosis.

  21. Experimental models of vascular dementia and vascular cognitive impairment: a systematic review

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. Journal of neurochemistry 2010-10-07 Brain tissue and pathology

    Vascular cognitive impairment (VCI) encompasses vascular dementia and is the second most common cause of dementing illness after Alzheimer's disease.

  22. In this large cohort study of elderly subjects, the degree of dVRS appears independently associated with age, hypertension, volume of white matter hyperintensities, and lacunar infarctions. dVRS should be considered as another MRI marker of cerebral small vessel disease in the elderly with regional variations in their severity.

  23. Distinct cerebral perfusion patterns in FTLD and AD

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. Neurology 2010-09-01 Brain scans and imaging

    Doubly dissociated areas of hypoperfusion in FTLD and AD are consistent with areas of significant histopathologic burden in these groups.

  24. Plasma ceramides are altered in mild cognitive impairment and predict cognitive decline and hippocampal volume loss

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2010-09-01 Mild cognitive impairment

    These plasma ceramides may be early indicators of AD progression.

  25. Predictors and assessment of cognitive dysfunction resulting from ischaemic stroke

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. The Lancet. Neurology 2010-09-01 Prevention and risk

    Stroke remains a primary cause of morbidity throughout the world mainly because of its effect on cognition.

  26. Diabetes, Alzheimer disease, and vascular dementia: a population-based neuropathologic study

    ✓ Peer-reviewed alzhub usefulness score 58 out of 100. Neurology 2010-08-25 Genetics

    Elderly patients with diabetes develop more extensive vascular pathology, which alone or together with AD-type pathology (particularly in APOE ε4 carriers) results in increased dementia risk.

  27. Cardiac index is associated with brain aging: the Framingham Heart Study

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. Circulation 2010-08-02 Brain scans and imaging

    Although observational data cannot establish causality, our findings are consistent with the hypothesis that decreasing cardiac function, even at normal cardiac index levels, is associated with accelerated brain aging.

  28. Nitric oxide signaling in brain function, dysfunction, and dementia

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry 2010-08-01 Vascular contributions

    Nitric oxide (NO) is an important signaling molecule that is widely used in the nervous system.

  29. The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: systematic review and meta-analysis

    ✓ Peer-reviewed alzhub usefulness score 56 out of 100. BMJ 2010-07-26 Vascular contributions

    White matter hyperintensities predict an increased risk of stroke, dementia, and death.

  30. Anatomical differences between CBS-corticobasal degeneration and CBS-Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Movement disorders : official journal of the Movement Disorder Society 2010-07-01 Brain scans and imaging

    We compare patterns of gray matter loss on MRI in subjects presenting as corticobasal syndrome (CBS) with Alzheimer disease pathology (CBS-AD) to those presenting as CBS with corticobasal degeneration pathology (CBS-CBD).

  31. Elucidating the nature of deregulated semantic cognition in semantic aphasia: evidence for the roles of prefrontal and temporo-parietal cortices

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Journal of cognitive neuroscience 2010-07-01 Vascular contributions

    Semantic cognition--semantically driven verbal and nonverbal behavior--is composed of at least two interactive principal components: conceptual representations and executive control processes that regulate and shape activation within the semantic system.

  32. We found differential region-specific associations between degenerative and vascular processes and the structural integrity of the CC across the spectrum of cognitive ability.

  33. Mild traumatic brain injury: a risk factor for neurodegeneration

    ✓ Peer-reviewed alzhub usefulness score 56 out of 100. Alzheimer's research & therapy 2010-06-25 Prevention and risk

    Recently, it has become clear that head trauma can lead to a progressive neurodegeneration known as chronic traumatic encephalopathy.

  34. Retinal microvascular signs and 10-year risk of cerebral atrophy: the Atherosclerosis Risk in Communities (ARIC) study

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Stroke 2010-06-24 Long-term cohort studies

    Cerebral atrophy, detected as ventricular enlargement or sulcal widening on MRI, is recognized as a risk factor for vascular dementia or Alzheimer disease.

  35. Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. The Lancet Neurology 2010-06-17 Vascular contributions

    The text describes cerebral small vessel disease as a group of pathological processes affecting the brain's small vessels, with age-related and hypertension-related forms and cerebral amyloid angiopathy being most common.

  36. Obesity is linked with lower brain volume in 700 AD and MCI patients

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. Neurobiology of aging 2010-06-08 Long-term cohort studies

    Obesity is associated with lower brain volumes in cognitively normal elderly subjects, but no study has yet investigated the effects of obesity on brain structure in patients with mild cognitive impairment (MCI) or Alzheimer's disease (AD).

  37. Systemic inflammation induces acute working memory deficits in the primed brain: relevance for delirium

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Neurobiology of aging 2010-05-14 Disease mechanisms

    Delirium is an acute, severe neuropsychiatric syndrome, characterized by cognitive deficits, that is highly prevalent in aging and dementia and is frequently precipitated by peripheral infections.

  38. ADF/Cofilin-actin rods in neurodegenerative diseases

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Current Alzheimer research 2010-05-01 Disease mechanisms

    Dephosphorylation (activation) of cofilin, an actin binding protein, is stimulated by initiators of neuronal dysfunction and degeneration including oxidative stress, excitotoxic glutamate, ischemia, and soluble forms of beta-amyloid peptide (Abeta).

  39. Microglia in neurodegenerative disease

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. Nature reviews. Neurology 2010-03-16 Inflammation and the immune system

    Microglia, the resident macrophages of the CNS, are exquisitely sensitive to brain injury and disease, altering their morphology and phenotype to adopt a so-called activated state in response to pathophysiological brain insults.

  40. Serum C-reactive protein is linked to cerebral microstructural integrity and cognitive function

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Neurology 2010-03-01 Vascular contributions

    These data suggest that low-grade inflammation as assessed by high-sensitivity C-reactive protein is associated with cerebral microstructural disintegration that predominantly affects frontal pathways and corresponding executive function.

  41. In a large community-based sample of middle-aged adults, BI predicted an increased risk of stroke and dementia independent of vascular risk factors.

  42. Systemic infection and delirium: when cytokines and acetylcholine collide

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. Lancet (London, England) 2010-02-01 Inflammation and the immune system

    Systemic infection and drugs with anticholinergic effects are well-recognised and prevalent risk factors for delirium in elderly people.

  43. Cerebrovascular dysfunction and microcirculation rarefaction precede white matter lesions in a mouse genetic model of cerebral ischemic small vessel disease

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. The Journal of clinical investigation 2010-01-11 Lewy body dementia

    Cerebral ischemic small vessel disease (SVD) is the leading cause of vascular dementia and a major contributor to stroke in humans.

  44. Vascular care in patients with Alzheimer disease with cerebrovascular lesions slows progression of WMLs.

  45. Transporters in the brain endothelial barrier

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Current medicinal chemistry 2010-01-01 Disease mechanisms

    The blood-brain barrier (BBB) not only impedes the influx of intravascular substances from blood to brain, but also promotes transport of substances from blood to brain or from brain to blood through several transport systems such as carrier-mediated transport, active efflux transport, and receptor-mediated transport systems.

  46. Anterior temporal involvement in semantic word retrieval: voxel-based lesion-symptom mapping evidence from aphasia

    ✓ Peer-reviewed alzhub usefulness score 74 out of 100. Brain : a journal of neurology 2009-12-01 Vascular contributions

    Analysis of error types provides useful information about the stages and processes involved in normal and aphasic word production.

  47. Differences in brain volume, hippocampal volume, cerebrovascular risk factors, and apolipoprotein E4 among mild cognitive impairment subtypes

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. Archives of neurology 2009-11-01 Brain scans and imaging

    Amnestic forms of MCI appear to have demographic, genetic, and MRI findings suggestive of Alzheimer disease pathology, whereas the nonamnestic forms of MCI have findings suggestive of vascular disease.

  48. Blood pressure lowering in patients without prior cerebrovascular disease for prevention of cognitive impairment and dementia

    ✓ Peer-reviewed alzhub usefulness score 67 out of 100. The Cochrane database of systematic reviews 2009-10-07 Prevention and risk

    Main results Four trials including 15,936 hypertensive subjects were identified.

  49. CNS inflammation and macrophage/microglial biology associated with HIV-1 infection

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2009-09-19 Inflammation and the immune system

    Human immunodeficiency virus type 1 (HIV-1) infection of the central nervous system (CNS) can result in neurological dysfunction with devastating consequences in a significant proportion of individuals with acquired immune deficiency syndrome.

  50. Extensive astrocyte infection is prominent in human immunodeficiency virus-associated dementia

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Annals of neurology 2009-08-01 Inflammation and the immune system

    Astrocyte infection with human immunodeficiency virus (HIV) is considered rare, so astrocytes are thought to play a secondary role in HIV neuropathogenesis.

From across this tag

10 of the 907 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

All topic tags with their study counts