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Home › Research › Topic

Brain proteins, microglia and lab models

4,766 studies in this group. A computer grouped them by what their titles and summaries are about, not by a hand-made list. The name describes most of the group, not every study in it.

Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Download bibliography of all 4,766 studies, highest score first: BibTeX (.bib) · RIS (.ris)

Highest usefulness score first. Studies without a score come last.

  1. Suboptimal hydration remodels metabolism, promotes degenerative diseases, and shortens life

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. JCI insight 2019-09-05 Long-term cohort studies

    With increased life expectancy worldwide, there is an urgent need for improving preventive measures that delay the development of age-related degenerative diseases.

    Why it matters

    This study reports evidence from mouse and human studies that maintaining optimal hydration throughout life may delay age-related degenerative diseases. It found that restricting drinking water shortened mouse lifespan and caused metabolic and inflammatory changes.

  2. A farnesyltransferase inhibitor activates lysosomes and reduces tau pathology in mice with tauopathy

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Science translational medicine 2019-03-01 Disease mechanisms

    Tau inclusions are a shared feature of many neurodegenerative diseases, among them frontotemporal dementia caused by tau mutations.

  3. Artificial intelligence in neuropathology: deep learning-based assessment of tauopathy

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Laboratory investigation; a journal of technical methods and pathology 2019-02-15 Disease mechanisms

    Accumulation of abnormal tau in neurofibrillary tangles (NFT) occurs in Alzheimer disease (AD) and a spectrum of tauopathies.

  4. Understanding the role of the perivascular space in cerebral small vessel disease

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Cardiovascular research 2018-09-01 Vascular contributions

    Small vessel diseases (SVDs) are a group of disorders that result from pathological alteration of the small blood vessels in the brain, including the small arteries, capillaries and veins.

  5. Benfotiamine treatment activates the Nrf2/ARE pathway and is neuroprotective in a transgenic mouse model of tauopathy

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Human molecular genetics 2018-08-01 Disease mechanisms

    Impaired glucose metabolism, decreased levels of thiamine and its phosphate esters, and reduced activity of thiamine-dependent enzymes, such as pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenase and transketolase occur in Alzheimer's disease (AD).

  6. Graphene quantum dots prevent α-synucleinopathy in Parkinson's disease

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Nature nanotechnology 2018-07-09 Lewy body dementia

    Though emerging evidence indicates that the pathogenesis of Parkinson's disease is strongly correlated to the accumulation 1,2 and transmission 3,4 of α-synuclein (α-syn) aggregates in the midbrain, no anti-aggregation agents have been successful at treating the disease in the clinic.

  7. Reversal of endothelial dysfunction reduces white matter vulnerability in cerebral small vessel disease in rats

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Science translational medicine 2018-07-01 Vascular contributions

    Dementia is a major social and economic problem for our aging population.

  8. Treatment of autonomic dysfunction in Parkinson disease and other synucleinopathies

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Movement disorders : official journal of the Movement Disorder Society 2018-03-01 Clinical safety

    Dysfunction of the autonomic nervous system afflicts most patients with Parkinson disease and other synucleinopathies such as dementia with Lewy bodies, multiple system atrophy, and pure autonomic failure, reducing quality of life and increasing mortality.

  9. Progranulin Gene Therapy Improves Lysosomal Dysfunction and Microglial Pathology Associated with Frontotemporal Dementia and Neuronal Ceroid Lipofuscinosis

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. The Journal of neuroscience : the official journal of the Society for Neuroscience 2018-01-29 Inflammation and the immune system

    AAV-mediated progranulin delivery reduced lipofuscinosis in Grn -/- mice even after the onset of pathology.

  10. The neuropathology of chronic traumatic encephalopathy

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Handbook of clinical neurology 2018-01-01 Disease mechanisms

    Chronic traumatic encephalopathy (CTE) is a neurodegenerative tauopathy associated with repetitive head trauma, including concussion and subconcussion.

  11. Distinct differences in prion-like seeding and aggregation between Tau protein variants provide mechanistic insights into tauopathies

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. The Journal of biological chemistry 2017-12-19 Disease mechanisms

    The accumulation of aberrantly aggregated MAPT (microtubule-associated protein Tau) defines a spectrum of tauopathies, including Alzheimer's disease.

  12. Neural basis of major depressive disorder: Beyond monoamine hypothesis

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Psychiatry and clinical neurosciences 2017-10-19 Hippocampus size on brain scans

    The monoamine hypothesis has been accepted as the most common hypothesis of major depressive disorder (MDD) for a long period because of its simplicity and understandability.

  13. Neuroprotective effects of a triple GLP-1/GIP/glucagon receptor agonist in the APP/PS1 transgenic mouse model of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Brain research 2017-10-16 Disease mechanisms

    Type 2 diabetes mellitus (T2DM) is a risk factor for Alzheimer disease (AD).

  14. Tau-based therapies in neurodegeneration: opportunities and challenges

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Nature reviews. Drug discovery 2017-10-06 Disease mechanisms

    Aggregates of the microtubule-associated protein tau are a defining feature of several neurodegenerative diseases that are collectively known as tauopathies, and constitute one of the hallmark lesions of Alzheimer disease (AD).

  15. Astrocyte-derived lipocalin-2 mediates hippocampal damage and cognitive deficits in experimental models of vascular dementia

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Glia 2017-06-05 Inflammation and the immune system

    Lipocalin-2 (LCN2) has diverse functions in multiple pathophysiological conditions; however, its pathogenic role in vascular dementia (VaD) is unknown.

  16. Calcineurin/NFAT Signaling in Activated Astrocytes Drives Network Hyperexcitability in Aβ-Bearing Mice

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. The Journal of neuroscience : the official journal of the Society for Neuroscience 2017-05-30 Clinical safety

    Hyperexcitable neuronal networks are mechanistically linked to the pathologic and clinical features of Alzheimer's disease (AD).

  17. The physiological phosphorylation of tau is critically changed in fetal brains of individuals with Down syndrome

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Neuropathology and applied neurobiology 2017-05-25 Down syndrome and Alzheimer's

    Our observations suggest functional tau disturbance in DS brains during development, rather than axonal loss.

    Why it matters

    This brain tissue study found that the normal phosphorylation of the tau protein was critically changed in fetal Down syndrome brains, suggesting tau problems begin early in development. The findings are from tissue analysis and suggest tau may play a role in cognitive impairment in Down syndrome and related Alzheimer's disease, but no treatment was tested.

  18. Stress and Loss of Adult Neurogenesis Differentially Reduce Hippocampal Volume

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Biological psychiatry 2017-05-22 Hippocampus size on brain scans

    The findings suggest that adult neurogenesis is required to maintain hippocampal volume but is not responsible for stress-induced volume loss.

  19. Binding Sites for Amyloid-β Oligomers and Synaptic Toxicity

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Cold Spring Harbor perspectives in medicine 2017-05-01 Disease mechanisms

    In Alzheimer's disease (AD), insoluble and fibrillary amyloid-β (Aβ) peptide accumulates in plaques.

  20. Prion-like Spreading in Tauopathies

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Biological psychiatry 2017-04-13 Disease mechanisms

    Tau is a microtubule-associated protein that functions in regulating cytoskeleton dynamics, especially in neurons.

  21. Targeting the HDAC2/HNF-4A/miR-101b/AMPK Pathway Rescues Tauopathy and Dendritic Abnormalities in Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Molecular therapy : the journal of the American Society of Gene Therapy 2017-02-13 Disease mechanisms

    Histone deacetylase 2 (HDAC2) plays a major role in the epigenetic regulation of gene expression.

  22. Novel Blood-Based Biomarkers of Cognition, Stress, and Physical or Cognitive Training in Older Adults at Risk of Dementia: Preliminary Evidence for a Role of BDNF, Irisin, and the Kynurenine Pathway

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Journal of Alzheimer's disease : JAD 2017-01-01 Prevention trials

    Psychosocial stress and physical, cognitive, and social activity predict the risk of cognitive decline and dementia.

  23. Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Science translational medicine 2017-01-01 Hippocampus size on brain scans

    Accumulation of hyperphosphorylated tau directly correlates with cognitive decline in Alzheimer's disease and other primary tauopathies.

  24. TNF-α Differentially Regulates Synaptic Plasticity in the Hippocampus and Spinal Cord by Microglia-Dependent Mechanisms after Peripheral Nerve Injury

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. The Journal of neuroscience : the official journal of the Society for Neuroscience 2017-01-01 Hippocampus size on brain scans

    Here, we show that the dendrite lengths and spine densities are reduced significantly in hippocampal CA1 pyramidal neurons, but increased in spinal neurokinin-1-positive neurons in mice after SNI, indicating that the excitatory synaptic connectivity is reduced in hippocampus but enhanced in spinal dorsal horn in this neuropathic pain model.

  25. [18 F]AV-1451 tau positron emission tomography in progressive supranuclear palsy

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Movement disorders : official journal of the Movement Disorder Society 2016-10-27 Disease mechanisms

    Progressive supranuclear palsy is associated with an elevated [ 18 F]AV-1451 signal in a characteristic and distinct regional pattern that correlates with disease severity and differs from the patterns observed in Alzheimer's dementia. © 2016 International Parkinson and Movement Disorder Society.

From across this topic

10 of the 4,748 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

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