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Factors regulating microglia activation
Kierdorf K, Prinz M.. Frontiers in cellular neuroscience, 2013-04-23
Topic: Brain proteins, microglia and lab models
Microglia are resident macrophages of the central nervous system (CNS) that display high functional similarities to other tissue macrophages. However, it is especially important to create and maintain an intact tissue homeostasis to support the neuronal cells, which are very sensitive even to minor changes in their environment. The transition from the "resting" but surveying microglial phenotype to an activated stage is tightly regulated by several intrinsic (e.g., Runx-1, Irf8, and Pu.1) and extrinsic factors (e.g., CD200, CX3CR1, and TREM2).
Key findings
- However, it is especially important to create and maintain an intact tissue homeostasis to support the neuronal cells, which are very sensitive even to minor changes in their environment.
- The transition from the "resting" but surveying microglial phenotype to an activated stage is tightly regulated by several intrinsic (e.g., Runx-1, Irf8, and Pu.1) and extrinsic factors (e.g., CD200, CX3CR1, and TREM2).
- Under physiological conditions, minor changes of those factors are sufficient to cause fatal dysregulation of microglial cell homeostasis and result in severe CNS pathologies.
- In this review, we discuss recent achievements that gave new insights into mechanisms that ensure microglia quiescence.
Why it matters
This is a review of factors that regulate microglial activation, including TREM2. It reports no new treatment, cure, or prevention for Alzheimer's disease.
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Study details
- Evidence strengthLow
How this study scored 49/100
Published in a peer-reviewed journal. Scored zero for study design, sample size, effect reported, studied in people and randomised / blinded because the record does not state it.
| Component | Points | Why |
|---|---|---|
| Journal tier | 7 / 10 | Tier 3 — peer-reviewed journal (Frontiers in cellular neuroscience) |
| Journal's citation record | 2 / 4 | Frontiers in Cellular Neuroscience: journal h-index 175 (OpenAlex, 2026-10-29) |
| Study design | 0 / 12 | No study design recorded — scores zero, not guessed (not stated in the record — scored 0) |
| Strength of evidence | 1 / 5 | Rated “low” in our summary |
| Peer-review validation | 10 / 10 | Peer-reviewed. Published as an article in a named peer-reviewed journal. |
| How recent | 1 / 5 | 2013 — within 20 year(s) of the newest study here |
| Sample size | 0 / 4 | Participant count not stated — scores zero (not stated in the record — scored 0) |
| Effect reported | 0 / 3 | No effect size reported — scores zero (not stated in the record — scored 0) |
| Studied in people | 0 / 3 | Not stated whether this was studied in people — scores zero (not stated in the record — scored 0) |
| Randomised / blinded | 0 / 2 | No randomisation or blinding stated — scores zero (not stated in the record — scored 0) |
| Times cited | 6 / 7 | Cited 358 times (OpenAlex, 2026-10-10) |
| Citations per year | 4 / 5 | 23.9 citations a year over 15 year(s) since 2013 |
| Impact for its field and year | 4 / 6 | Cited 14.8× the average for papers of its field and year (OpenAlex FWCI) |
| Cited by studies here | 2 / 6 | Cited by 6 other studies in this library |
| Still being cited | 3 / 4 | Cited 50 times in 2024–2026 (2026 still in progress; OpenAlex) |
| Senior author's track record | 4 / 4 | Last-listed author Marco Prinz: h-index 131 (OpenAlex, whole career) |
| Institution's track record | 1 / 3 | University of Freiburg: institution h-index 1,068 (OpenAlex) |
| Multi-centre collaboration | 0 / 3 | OpenAlex lists 1 institution(s) in 1 country — scores zero (affiliation lists can be incomplete) |
| Indexed in PubMed | 2 / 2 | Indexed in PubMed (PMID 23630462) |
| Free to read | 2 / 2 | Free to read |
| Total | 49 / 100 | — |
What each of these 20 components measures, and what this score is not →
Read the original
- DOI: 10.3389/fncel.2013.00044
- PubMed: 23630462
- Original source →
- Free full text: Frontiers in Cellular Neuroscience →
Full text: free to read — OpenAlex lists this copy as free to read: the link above (checked 6 Feb 1020).
Cite this study APA, Vancouver, BibTeX · download .bib or .ris
Built from the record alzhub holds for this paper, not looked up. Volume, issue and page numbers are not held in the record. Check the citation against the original before you use it.
APA 7th
Kierdorf, K., & Prinz, M. (2013). Factors regulating microglia activation. Frontiers in cellular neuroscience. https://doi.org/10.3389/fncel.2013.00044
Vancouver
Kierdorf K, Prinz M. Factors regulating microglia activation. Frontiers in cellular neuroscience. 2013. doi:10.3389/fncel.2013.00044. PMID: 23630462.
BibTeX
@article{kierdorf2013-23630462,
author = {Kierdorf, K. and Prinz, M.},
title = {{Factors regulating microglia activation}},
journal = {Frontiers in cellular neuroscience},
year = {2013},
doi = {10.3389/fncel.2013.00044},
pmid = {23630462},
url = {https://doi.org/10.3389/fncel.2013.00044}
}
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