% alzhub.org topic: Brain proteins, microglia and lab models
% Source: https://alzhub.org/topic/tau-protein
% 4766 entries, in the order the page lists them. Built from alzhub.org's own records.
% 3 entries have no readable author in the source record and carry no author field.

@article{sims2017-28714976,
  author  = {Sims, R. and van der Lee, S. J. and Naj, A. C. and Bellenguez, C. and Badarinarayan, N. and Jakobsdottir, J. and Kunkle, B. W. and Boland, A. and others},
  title   = {{Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease}},
  journal = {Nature genetics},
  year    = {2017},
  doi     = {10.1038/ng.3916},
  pmid    = {28714976},
  url     = {https://doi.org/10.1038/ng.3916}
}

@article{gilman2005-15883316,
  author  = {Gilman, S. and Koller, M. and Black, R. S. and Jenkins, L. and Griffith, S. G. and Fox, N. C. and Eisner, L. and Kirby, L. and others},
  title   = {{Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial}},
  journal = {Neurology},
  year    = {2005},
  doi     = {10.1212/01.wnl.0000159740.16984.3c},
  pmid    = {15883316},
  url     = {https://doi.org/10.1212/01.wnl.0000159740.16984.3c}
}

@article{ossenkoppele2025-40155777,
  author  = {Ossenkoppele, R. and Salvadó, G. and Janelidze, S. and Pichet Binette, A. and Bali, D. and Karlsson, L. and Palmqvist, S. and Mattsson-Carlgren, N. and Stomrud, E. and Therriault, J. and Rahmouni, N. and Rosa-Neto, P. and others},
  title   = {{Plasma p-tau217 and tau-PET predict future cognitive decline among cognitively unimpaired individuals: implications for clinical trials}},
  journal = {Nature Aging},
  year    = {2025},
  doi     = {10.1038/s43587-025-00835-z},
  pmid    = {40155777},
  url     = {https://doi.org/10.1038/s43587-025-00835-z}
}

@article{warmenhoven2025-39468767,
  author  = {Warmenhoven, N. and Salvadó, G. and Janelidze, S. and Mattsson-Carlgren, N. and Bali, D. and Orduña Dolado, A. and Kolb, H. and Triana-Baltzer, G. and Barthélemy, N. R. and Schindler, S. E. and Aschenbrenner, A. J. and Raji, C. A. and others},
  title   = {{A comprehensive head-to-head comparison of key plasma phosphorylated tau 217 biomarker tests}},
  journal = {Brain},
  year    = {2025},
  doi     = {10.1093/brain/awae346},
  pmid    = {39468767},
  url     = {https://doi.org/10.1093/brain/awae346}
}

@article{solomon2018-29356827,
  author  = {Solomon, A. and Turunen, H. and Ngandu, T. and Peltonen, M. and Levälahti, E. and Helisalmi, S. and Antikainen, R. and Bäckman, L. and others},
  title   = {{Effect of the Apolipoprotein E Genotype on Cognitive Change During a Multidomain Lifestyle Intervention: A Subgroup Analysis of a Randomized Clinical Trial}},
  journal = {JAMA neurology},
  year    = {2018},
  doi     = {10.1001/jamaneurol.2017.4365},
  pmid    = {29356827},
  url     = {https://doi.org/10.1001/jamaneurol.2017.4365}
}

@article{thompson2014-24399358,
  author  = {Thompson, P. M. and Stein, J. L. and Medland, S. E. and Hibar, D. P. and Vasquez, A. A. and Renteria, M. E. and Toro, R. and Jahanshad, N. and others},
  title   = {{The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data}},
  journal = {Brain imaging and behavior},
  year    = {2014},
  doi     = {10.1007/s11682-013-9269-5},
  pmid    = {24399358},
  url     = {https://doi.org/10.1007/s11682-013-9269-5}
}

@article{pereira2021-34259835,
  author  = {Pereira, J. B. and Janelidze, S. and Smith, R. and Mattsson-Carlgren, N. and Palmqvist, S. and Teunissen, C. E. and Zetterberg, H. and Stomrud, E. and others},
  title   = {{Plasma GFAP is an early marker of amyloid-β but not tau pathology in Alzheimer's disease}},
  journal = {Brain : a journal of neurology},
  year    = {2021},
  doi     = {10.1093/brain/awab223},
  pmid    = {34259835},
  url     = {https://doi.org/10.1093/brain/awab223}
}

@article{hibar2017-28098162,
  author  = {Hibar, D. P. and Adams, H. H. H. and Jahanshad, N. and Chauhan, G. and Stein, J. L. and Hofer, E. and Renteria, M. E. and Bis, J. C. and others},
  title   = {{Novel genetic loci associated with hippocampal volume}},
  journal = {Nature communications},
  year    = {2017},
  doi     = {10.1038/ncomms13624},
  pmid    = {28098162},
  url     = {https://doi.org/10.1038/ncomms13624}
}

@article{henderson2016-26795874,
  author  = {Henderson, E. J. and Lord, SR. and Brodie, M. A. and Gaunt, D. M. and Lawrence, A. D. and Close, J. C. and Whone, A. L. and others},
  title   = {{Rivastigmine for gait stability in patients with Parkinson's disease (ReSPonD): a randomised, double-blind, placebo-controlled, phase 2 trial}},
  journal = {The Lancet. Neurology},
  year    = {2016},
  doi     = {10.1016/s1474-4422(15)00389-0},
  pmid    = {26795874},
  url     = {https://doi.org/10.1016/s1474-4422(15)00389-0}
}

@article{smith2010-20838622,
  author  = {Smith, A. D. and Smith, S. M. and de Jager, C. A. and Whitbread, P. and Johnston, C. and Agacinski, G. and Oulhaj, A. and Bradley, K. M. and others},
  title   = {{Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial}},
  journal = {PloS one},
  year    = {2010},
  doi     = {10.1371/journal.pone.0012244},
  pmid    = {20838622},
  url     = {https://doi.org/10.1371/journal.pone.0012244}
}

@article{pascoal2021-34446931,
  author  = {Pascoal, T. A. and Benedet, A. L. and Ashton, N. J. and Kang, M. S. and Therriault, J. and Chamoun, M. and Savard, M. and Lussier, F. Z. and others},
  title   = {{Microglial activation and tau propagate jointly across Braak stages}},
  journal = {Nature medicine},
  year    = {2021},
  doi     = {10.1038/s41591-021-01456-w},
  pmid    = {34446931},
  url     = {https://doi.org/10.1038/s41591-021-01456-w}
}

@article{erickson2011-21282661,
  author  = {Erickson, K. I. and Voss, M. W. and Prakash, R. S. and Basak, C. and Szabo, A. and Chaddock, L. and Kim, J. S. and Heo, S. and others},
  title   = {{Exercise training increases size of hippocampus and improves memory}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2011},
  doi     = {10.1073/pnas.1015950108},
  pmid    = {21282661},
  url     = {https://doi.org/10.1073/pnas.1015950108}
}

@article{moscoso2025-40522652,
  author  = {Moscoso, Alexis and Heeman, Fiona and Raghavan, Sheelakumari and Costoya‐Sánchez, Alejandro and van Essen, Martijn and Mainta, Ismini and Camacho, Valle and Rodríguez-Fonseca, Omar Darío and others},
  title   = {{Frequency and Clinical Outcomes Associated With Tau Positron Emission Tomography Positivity}},
  journal = {JAMA},
  year    = {2025},
  doi     = {10.1001/jama.2025.7817},
  pmid    = {40522652},
  url     = {https://doi.org/10.1001/jama.2025.7817}
}

@article{wang2025-40172303,
  author  = {Wang, H. and Serap Monkul Nery, E. and Ardayfio, P. and Khanna, R. and Otero Svaldi, D. and Gueorguieva, I. and Shcherbinin, S. and Andersen, S. W. and Hauck, P. M. and Engle, S. E. and others},
  title   = {{Modified titration of donanemab reduces ARIA risk and maintains amyloid reduction}},
  journal = {Alzheimer's \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz.70062},
  pmid    = {40172303},
  url     = {https://doi.org/10.1002/alz.70062}
}

@article{janelidze2024-39068669,
  author  = {Janelidze, S. and Barthélemy, N. R. and Salvadó, G. and Schindler, S. E. and Palmqvist, S. and Mattsson-Carlgren, N. and Braunstein, J. B. and Ovod, V. and Bollinger, J. G. and He, Y. and Li, Y. and Raji, C. A. and others},
  title   = {{Plasma Phosphorylated Tau 217 and Aβ42/40 to Predict Early Brain Aβ Accumulation in People Without Cognitive Impairment}},
  journal = {JAMA Neurology},
  year    = {2024},
  doi     = {10.1001/jamaneurol.2024.2619},
  pmid    = {39068669},
  url     = {https://doi.org/10.1001/jamaneurol.2024.2619}
}

@article{shanks2024-38760589,
  author  = {Shanks, H. R. C. and Chen, K. and Reiman, E. M. and Blennow, K. and Cummings, J. L. and Massa, S. M. and Longo, F. M. and Börjesson-Hanson, A. and others},
  title   = {{p75 neurotrophin receptor modulation in mild to moderate Alzheimer disease: a randomized, placebo-controlled phase 2a trial}},
  journal = {Nature medicine},
  year    = {2024},
  doi     = {10.1038/s41591-024-02977-w},
  pmid    = {38760589},
  url     = {https://doi.org/10.1038/s41591-024-02977-w}
}

@article{shcherbinin2022-36094645,
  author  = {Shcherbinin, S. and Evans, C. D. and Lu, M. and Andersen, S. W. and Pontecorvo, M. J. and Willis, B. A. and Gueorguieva, I. and Hauck, P. M. and others},
  title   = {{Association of Amyloid Reduction After Donanemab Treatment With Tau Pathology and Clinical Outcomes: The TRAILBLAZER-ALZ Randomized Clinical Trial}},
  journal = {JAMA neurology},
  year    = {2022},
  doi     = {10.1001/jamaneurol.2022.2793},
  pmid    = {36094645},
  url     = {https://doi.org/10.1001/jamaneurol.2022.2793}
}

@article{liu2021-34527222,
  author  = {Liu, X. and Dhana, K. and Furtado, J. D. and Agarwal, P. and Aggarwal, N. T. and Tangney, C. and Laranjo, N. and Carey, V. and others},
  title   = {{Higher circulating α-carotene was associated with better cognitive function: an evaluation among the MIND trial participants}},
  journal = {Journal of nutritional science},
  year    = {2021},
  doi     = {10.1017/jns.2021.56},
  pmid    = {34527222},
  url     = {https://doi.org/10.1017/jns.2021.56}
}

@article{nilsson2020-32157099,
  author  = {Nilsson, J. and Ö, Ekblom and Ekblom, M. and Lebedev, A. and Tarassova, O. and Moberg, M. and Lövdén, M.},
  title   = {{Acute increases in brain-derived neurotrophic factor in plasma following physical exercise relates to subsequent learning in older adults}},
  journal = {Scientific reports},
  year    = {2020},
  doi     = {10.1038/s41598-020-60124-0},
  pmid    = {32157099},
  url     = {https://doi.org/10.1038/s41598-020-60124-0}
}

@article{stephen2020-32925045,
  author  = {Stephen, R. and Solomon, A. and Ngandu, T. and Levälahti, E. and Rinne, J. O. and Kemppainen, N. and Parkkola, R. and Antikainen, R. and others},
  title   = {{White Matter Changes on Diffusion Tensor Imaging in the FINGER Randomized Controlled Trial}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2020},
  doi     = {10.3233/jad-200423},
  pmid    = {32925045},
  url     = {https://doi.org/10.3233/jad-200423}
}

@article{logue2018-29217296,
  author  = {Logue, M. W. and van Rooij, S. J. H. and Dennis, E. L. and Davis, S. L. and Hayes, J. P. and Stevens, J. S. and Densmore, M. and Haswell, C. C. and others},
  title   = {{Smaller Hippocampal Volume in Posttraumatic Stress Disorder: A Multisite ENIGMA-PGC Study: Subcortical Volumetry Results From Posttraumatic Stress Disorder Consortia}},
  journal = {Biological psychiatry},
  year    = {2018},
  doi     = {10.1016/j.biopsych.2017.09.006},
  pmid    = {29217296},
  url     = {https://doi.org/10.1016/j.biopsych.2017.09.006}
}

@article{sampson2007-17006875,
  author  = {Sampson, E. L. and Raven, P. R. and Ndhlovu, P. N. and Vallance, A. and Garlick, N. and Watts, J. and Blanchard, M. R. and Bruce, A. and others},
  title   = {{A randomized, double-blind, placebo-controlled trial of donepezil hydrochloride (Aricept) for reducing the incidence of postoperative delirium after elective total hip replacement}},
  journal = {International journal of geriatric psychiatry},
  year    = {2007},
  doi     = {10.1002/gps.1679},
  pmid    = {17006875},
  url     = {https://doi.org/10.1002/gps.1679}
}

@article{pottier2025-40280976,
  author  = {Pottier, Cyril P. and Küçükali, Fahri and Baker, Matt C. and Batzler, Anthony and Jenkins, Gregory D. and van Blitterswijk, Marka and Vicente, Cristina T. and De Coster, Wouter and others},
  title   = {{Deciphering distinct genetic risk factors for FTLD-TDP pathological subtypes via whole-genome sequencing}},
  journal = {Nature Communications},
  year    = {2025},
  doi     = {10.1038/s41467-025-59216-0},
  pmid    = {40280976},
  url     = {https://doi.org/10.1038/s41467-025-59216-0}
}

@article{cummings2015-26393847,
  author  = {Cummings, J. L. and Lyketsos, C. G. and Peskind, E. R. and Porsteinsson, A. P. and Mintzer, J. E. and Scharre, D. W. and De La Gandara, J. E. and Agronin, M. and others},
  title   = {{Effect of Dextromethorphan-Quinidine on Agitation in Patients With Alzheimer Disease Dementia: A Randomized Clinical Trial}},
  journal = {JAMA},
  year    = {2015},
  doi     = {10.1001/jama.2015.10214},
  pmid    = {26393847},
  url     = {https://doi.org/10.1001/jama.2015.10214}
}

@article{lill2015-25936935,
  author  = {Lill, C. M. and Rengmark, A. and Pihlstrøm, L. and Fogh, I. and Shatunov, A. and Sleiman, P. M. and Wang, L. S. and Liu, T. and others},
  title   = {{The role of TREM2 R47H as a risk factor for Alzheimer's disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson's disease}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2015},
  doi     = {10.1016/j.jalz.2014.12.009},
  pmid    = {25936935},
  url     = {https://doi.org/10.1016/j.jalz.2014.12.009}
}

@article{fornage2011-21681796,
  author  = {Fornage, M. and Debette, S. and Bis, J. C. and Schmidt, H. and Ikram, M. A. and Dufouil, C. and Sigurdsson, S. and Lumley, T. and others},
  title   = {{Genome-wide association studies of cerebral white matter lesion burden: the CHARGE consortium}},
  journal = {Annals of neurology},
  year    = {2011},
  doi     = {10.1002/ana.22403},
  pmid    = {21681796},
  url     = {https://doi.org/10.1002/ana.22403}
}

@article{mckeith2000-11145488,
  author  = {McKeith, I. and Del Ser, T. and Spano, P. and Emre, M. and Wesnes, K. and Anand, R. and Cicin-Sain, A. and Ferrara, R. and others},
  title   = {{Efficacy of rivastigmine in dementia with Lewy bodies: a randomised, double-blind, placebo-controlled international study}},
  journal = {Lancet (London, England)},
  year    = {2000},
  doi     = {10.1016/s0140-6736(00)03399-7},
  pmid    = {11145488},
  url     = {https://doi.org/10.1016/s0140-6736(00)03399-7}
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@article{rojas2021-33827960,
  author  = {Rojas, J. C. and Wang, P. and Staffaroni, A. M. and Heller, C. and Cobigo, Y. and Wolf, A. and Goh, S. M. and Ljubenkov, P. A. and others},
  title   = {{Plasma Neurofilament Light for Prediction of Disease Progression in Familial Frontotemporal Lobar Degeneration}},
  journal = {Neurology},
  year    = {2021},
  doi     = {10.1212/wnl.0000000000011848},
  pmid    = {33827960},
  url     = {https://doi.org/10.1212/wnl.0000000000011848}
}

@article{firth2018-29113943,
  author  = {Firth, J. and Stubbs, B. and Vancampfort, D. and Schuch, F. and Lagopoulos, J. and Rosenbaum, S. and Ward, P. B.},
  title   = {{Effect of aerobic exercise on hippocampal volume in humans: A systematic review and meta-analysis}},
  journal = {NeuroImage},
  year    = {2018},
  doi     = {10.1016/j.neuroimage.2017.11.007},
  pmid    = {29113943},
  url     = {https://doi.org/10.1016/j.neuroimage.2017.11.007}
}

@article{ruiz2014-24041969,
  author  = {Ruiz, A. and Dols-Icardo, O. and Bullido, M. J. and Pastor, P. and Rodríguez-Rodríguez, E. and López de Munain, A. and de Pancorbo, M. M. and Pérez-Tur, J. and others},
  title   = {{Assessing the role of the TREM2 p.R47H variant as a risk factor for Alzheimer's disease and frontotemporal dementia}},
  journal = {Neurobiology of aging},
  year    = {2014},
  doi     = {10.1016/j.neurobiolaging.2013.08.011},
  pmid    = {24041969},
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}

@article{rolinski2012-22419314,
  author  = {Rolinski, M. and Fox, C. and Maidment, I. and McShane, R.},
  title   = {{Cholinesterase inhibitors for dementia with Lewy bodies, Parkinson's disease dementia and cognitive impairment in Parkinson's disease}},
  journal = {The Cochrane database of systematic reviews},
  year    = {2012},
  doi     = {10.1002/14651858.cd006504.pub2},
  pmid    = {22419314},
  url     = {https://doi.org/10.1002/14651858.cd006504.pub2}
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@article{schwartz2009-19942676,
  author  = {Schwartz, M. F. and Kimberg, D. Y. and Walker, G. M. and Faseyitan, O. and Brecher, A. and Dell, G. S. and Coslett, H. B.},
  title   = {{Anterior temporal involvement in semantic word retrieval: voxel-based lesion-symptom mapping evidence from aphasia}},
  journal = {Brain : a journal of neurology},
  year    = {2009},
  doi     = {10.1093/brain/awp284},
  pmid    = {19942676},
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@article{resnick2009-19139364,
  author  = {Resnick, S. M. and Espeland, M. A. and Jaramillo, S. A. and Hirsch, C. and Stefanick, M. L. and Murray, A. M. and Ockene, J. and Davatzikos, C.},
  title   = {{Postmenopausal hormone therapy and regional brain volumes: the WHIMS-MRI Study}},
  journal = {Neurology},
  year    = {2009},
  doi     = {10.1212/01.wnl.0000339037.76336.cf},
  pmid    = {19139364},
  url     = {https://doi.org/10.1212/01.wnl.0000339037.76336.cf}
}

@article{smith2005-15988763,
  author  = {Smith, M. E.},
  title   = {{Bilateral hippocampal volume reduction in adults with post-traumatic stress disorder: a meta-analysis of structural MRI studies}},
  journal = {Hippocampus},
  year    = {2005},
  doi     = {10.1002/hipo.20102},
  pmid    = {15988763},
  url     = {https://doi.org/10.1002/hipo.20102}
}

@article{study2026-c3d280c0,
  title   = {{The glymphatic system clears amyloid beta and tau from brain to plasma in humans}},
  journal = {Nature Communications},
  year    = {2026}
}

@article{tsai2020-31710340,
  author  = {Tsai, R. M. and Miller, Z. and Koestler, M. and Rojas, J. C. and Ljubenkov, P. A. and Rosen, H. J. and Rabinovici, G. D. and Fagan, A. M. and others},
  title   = {{Reactions to Multiple Ascending Doses of the Microtubule Stabilizer TPI-287 in Patients With Alzheimer Disease, Progressive Supranuclear Palsy, and Corticobasal Syndrome: A Randomized Clinical Trial}},
  journal = {JAMA neurology},
  year    = {2020},
  doi     = {10.1001/jamaneurol.2019.3812},
  pmid    = {31710340},
  url     = {https://doi.org/10.1001/jamaneurol.2019.3812}
}

@article{chew2015-26305649,
  author  = {Chew, E. Y. and Clemons, T. E. and Agrón, E. and Launer, L. J. and Grodstein, F. and Bernstein, P. S.},
  title   = {{Effect of Omega-3 Fatty Acids, Lutein/Zeaxanthin, or Other Nutrient Supplementation on Cognitive Function: The AREDS2 Randomized Clinical Trial}},
  journal = {JAMA},
  year    = {2015},
  doi     = {10.1001/jama.2015.9677},
  pmid    = {26305649},
  url     = {https://doi.org/10.1001/jama.2015.9677}
}

@article{anderson2011-20980201,
  author  = {Anderson, C. and Teo, K. and Gao, P. and Arima, H. and Dans, A. and Unger, T. and Commerford, P. and Dyal, L. and others},
  title   = {{Renin-angiotensin system blockade and cognitive function in patients at high risk of cardiovascular disease: analysis of data from the ONTARGET and TRANSCEND studies}},
  journal = {The Lancet. Neurology},
  year    = {2011},
  doi     = {10.1016/s1474-4422(10)70250-7},
  pmid    = {20980201},
  url     = {https://doi.org/10.1016/s1474-4422(10)70250-7}
}

@article{temba2025-40181181,
  author  = {Temba, Godfrey S. and Pecht, Tal and Kullaya, Vesla I. and Vadaq, Nadira and Mosha, Mary and Ulas, Thomas and Kanungo, Sneha and van Emst, Liesbeth and others},
  title   = {{Immune and metabolic effects of African heritage diets versus Western diets in men: a randomized controlled trial}},
  journal = {Nature Medicine},
  year    = {2025},
  doi     = {10.1038/s41591-025-03602-0},
  pmid    = {40181181},
  url     = {https://doi.org/10.1038/s41591-025-03602-0}
}

@article{nilsson2024-38325331,
  author  = {Nilsson, J. and Pichet Binette, A. and Palmqvist, S. and Brum, W. S. and Janelidze, S. and Ashton, N. J. and Spotorno, N. and Stomrud, E. and others},
  title   = {{Cerebrospinal fluid biomarker panel for synaptic dysfunction in a broad spectrum of neurodegenerative diseases}},
  journal = {Brain : a journal of neurology},
  year    = {2024},
  doi     = {10.1093/brain/awae032},
  pmid    = {38325331},
  url     = {https://doi.org/10.1093/brain/awae032}
}

@article{bhattarai2024-38598053,
  author  = {Bhattarai, P. and Gunasekaran, T. I. and Belloy, M. E. and Reyes-Dumeyer, D. and Jülich, D. and Tayran, H. and Yilmaz, E. and Flaherty, D. and Turgutalp, B. and Sukumar, G. and Alba, C. and McGrath, E. M. and others},
  title   = {{Rare genetic variation in fibronectin 1 (FN1) protects against APOEε4 in Alzheimer's disease}},
  journal = {Acta Neuropathologica},
  year    = {2024},
  doi     = {10.1007/s00401-024-02721-1},
  pmid    = {38598053},
  url     = {https://doi.org/10.1007/s00401-024-02721-1}
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@article{rivasi2025-40067602,
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  title   = {{Plasma proteomics for cognitive decline and dementia—A Southeast Asian cohort study}},
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  title   = {{Lipid-associated macrophages' promotion of fibrosis resolution during MASH regression requires TREM2}},
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  title   = {{Apolipoprotein E4 impairs the response of neurodegenerative retinal microglia and prevents neuronal loss in glaucoma}},
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  title   = {{TREM2-dependent lipid droplet biogenesis in phagocytes is required for remyelination}},
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  title   = {{Oxidized phosphatidylcholines found in multiple sclerosis lesions mediate neurodegeneration and are neutralized by microglia}},
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  title   = {{Plasma phosphorylated tau (p-tau231) and total tau (t-tau) as prognostic markers of neurological outcome after cardiac arrest - a multicentre study}},
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@article{fabre2023-37027478,
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  title   = {{Identification of a broadly fibrogenic macrophage subset induced by type 3 inflammation}},
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@article{wang2023-36521495,
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  title   = {{Prolonged hypernutrition impairs TREM2-dependent efferocytosis to license chronic liver inflammation and NASH development}},
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  year    = {2023},
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  title   = {{TREM2-independent microgliosis promotes tau-mediated neurodegeneration in the presence of ApoE4}},
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@article{wong2022-36229464,
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  title   = {{Single cell analysis of cribriform prostate cancer reveals cell intrinsic and tumor microenvironmental pathways of aggressive disease}},
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@article{zhao2022-36107206,
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  title   = {{Elevating microglia TREM2 reduces amyloid seeding and suppresses disease-associated microglia}},
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@article{do2022-35867799,
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  title   = {{TREM2 macrophages induced by human lipids drive inflammation in acne lesions}},
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  pmid    = {35867799},
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@article{simon2022-35473943,
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  title   = {{Loss of perivascular aquaporin-4 localization impairs glymphatic exchange and promotes amyloid β plaque formation in mice}},
  journal = {Alzheimer's research \& therapy},
  year    = {2022},
  doi     = {10.1186/s13195-022-00999-5},
  pmid    = {35473943},
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@article{nunes2022-35130181,
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  title   = {{Cholesterol metabolism in aging simultaneously altered in liver and nervous system}},
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@article{you2022-35029059,
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  title   = {{Human neural cell type-specific extracellular vesicle proteome defines disease-related molecules associated with activated astrocytes in Alzheimer's disease brain}},
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@article{sayed2021-34851693,
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  title   = {{AD-linked R47H-TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation}},
  journal = {Science translational medicine},
  year    = {2021},
  doi     = {10.1126/scitranslmed.abe3947},
  pmid    = {34851693},
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  title   = {{Integrative brain transcriptome analysis links complement component 4 and HSPA2 to the APOE ε2 protective effect in Alzheimer disease}},
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@article{logan2021-34450028,
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  title   = {{Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic}},
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@article{malik2021-34140671,
  author  = {Malik, I. and Kelley, C. P. and Wang, E. T. and Todd, P. K.},
  title   = {{Molecular mechanisms underlying nucleotide repeat expansion disorders}},
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  year    = {2021},
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@article{iizasa2021-33863908,
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  title   = {{TREM2 is a receptor for non-glycosylated mycolic acids of mycobacteria that limits anti-mycobacterial macrophage activation}},
  journal = {Nature communications},
  year    = {2021},
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  title   = {{TauIQ: A Canonical Image Based Algorithm to Quantify Tau PET Scans}},
  journal = {Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year    = {2021},
  doi     = {10.2967/jnumed.120.258962},
  pmid    = {33517326},
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  title   = {{The SARS-CoV-2 spike protein alters barrier function in 2D static and 3D microfluidic in-vitro models of the human blood-brain barrier}},
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  year    = {2020},
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@article{belbin2020-32807227,
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  title   = {{Cerebrospinal fluid profile of NPTX2 supports role of Alzheimer's disease-related inhibitory circuit dysfunction in adults with Down syndrome}},
  journal = {Molecular neurodegeneration},
  year    = {2020},
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  title   = {{Coupled scRNA-Seq and Intracellular Protein Activity Reveal an Immunosuppressive Role of TREM2 in Cancer}},
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  pmid    = {32783915},
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  title   = {{Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain}},
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@article{chen2020-32466767,
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  title   = {{TREM2 activation attenuates neuroinflammation and neuronal apoptosis via PI3K/Akt pathway after intracerebral hemorrhage in mice}},
  journal = {Journal of neuroinflammation},
  year    = {2020},
  doi     = {10.1186/s12974-020-01853-x},
  pmid    = {32466767},
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@article{vanveen2020-31996848,
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  title   = {{ATP13A2 deficiency disrupts lysosomal polyamine export}},
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@article{nugent2020-31902528,
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  title   = {{TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge}},
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  year    = {2020},
  doi     = {10.1016/j.neuron.2019.12.007},
  pmid    = {31902528},
  url     = {https://doi.org/10.1016/j.neuron.2019.12.007}
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@article{zhang2020-31903107,
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  title   = {{Microglia exacerbate white matter injury via complement C3/C3aR pathway after hypoperfusion}},
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  year    = {2020},
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  title   = {{Synaptic biomarkers in CSF aid in diagnosis, correlate with cognition and predict progression in MCI and Alzheimer's disease}},
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  year    = {2019},
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  pmid    = {31853477},
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@article{wang2020-31825859,
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  title   = {{Spatial-Temporal Dependency Modeling and Network Hub Detection for Functional MRI Analysis via Convolutional-Recurrent Network}},
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  year    = {2020},
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@article{harrison2019-31653847,
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  title   = {{Tau deposition is associated with functional isolation of the hippocampus in aging}},
  journal = {Nature communications},
  year    = {2019},
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  pmid    = {31653847},
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@article{ewers2019-31462511,
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  title   = {{Increased soluble TREM2 in cerebrospinal fluid is associated with reduced cognitive and clinical decline in Alzheimer's disease}},
  journal = {Science translational medicine},
  year    = {2019},
  doi     = {10.1126/scitranslmed.aav6221},
  pmid    = {31462511},
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@article{delaguila2019-31068200,
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  title   = {{TREM2 brain transcript-specific studies in AD and TREM2 mutation carriers}},
  journal = {Molecular neurodegeneration},
  year    = {2019},
  doi     = {10.1186/s13024-019-0319-3},
  pmid    = {31068200},
  url     = {https://doi.org/10.1186/s13024-019-0319-3}
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@article{baker2019-30877180,
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  title   = {{Effect of Off-Target Binding on 18F-Flortaucipir Variability in Healthy Controls Across the Life Span}},
  journal = {Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year    = {2019},
  doi     = {10.2967/jnumed.118.224113},
  pmid    = {30877180},
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@article{marinescu2019-30844504,
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  title   = {{DIVE: A spatiotemporal progression model of brain pathology in neurodegenerative disorders}},
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  year    = {2019},
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  pmid    = {30844504},
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@article{mann2019-30826182,
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  title   = {{RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43}},
  journal = {Neuron},
  year    = {2019},
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  pmid    = {30826182},
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@article{rauchmann2019-30458365,
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  title   = {{CSF soluble TREM2 as a measure of immune response along the Alzheimer's disease continuum}},
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  year    = {2019},
  doi     = {10.1016/j.neurobiolaging.2018.10.022},
  pmid    = {30458365},
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  title   = {{Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy}},
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  year    = {2018},
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  pmid    = {30232263},
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  title   = {{Lewy Body Pathology and Chronic Traumatic Encephalopathy Associated With Contact Sports}},
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@article{teipel2018-30158893,
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  title   = {{Basal Forebrain Volume, but Not Hippocampal Volume, Is a Predictor of Global Cognitive Decline in Patients With Alzheimer's Disease Treated With Cholinesterase Inhibitors}},
  journal = {Frontiers in neurology},
  year    = {2018},
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  pmid    = {30158893},
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@article{mcgurk2018-30100264,
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  title   = {{Poly(ADP-Ribose) Prevents Pathological Phase Separation of TDP-43 by Promoting Liquid Demixing and Stress Granule Localization}},
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  pmid    = {30100264},
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@article{carmona2018-30033062,
  author  = {Carmona, S. and Zahs, K. and Wu, E. and Dakin, K. and Bras, J. and Guerreiro, R.},
  title   = {{The role of TREM2 in Alzheimer's disease and other neurodegenerative disorders}},
  journal = {The Lancet. Neurology},
  year    = {2018},
  doi     = {10.1016/s1474-4422(18)30232-1},
  pmid    = {30033062},
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@article{chenghathaway2018-29859094,
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  title   = {{The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer's disease}},
  journal = {Molecular neurodegeneration},
  year    = {2018},
  doi     = {10.1186/s13024-018-0262-8},
  pmid    = {29859094},
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@article{portelius2018-29700597,
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  title   = {{Cerebrospinal fluid neurogranin concentration in neurodegeneration: relation to clinical phenotypes and neuropathology}},
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  title   = {{Optical coherence tomography identifies outer retina thinning in frontotemporal degeneration}},
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  title   = {{The seeds of neurodegeneration: prion-like spreading in ALS}},
  journal = {Cell},
  year    = {2011},
  doi     = {10.1016/j.cell.2011.10.011},
  pmid    = {22036560},
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}

@article{lee2011-21593437,
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  title   = {{Identification of pure subcortical vascular dementia using 11C-Pittsburgh compound B}},
  journal = {Neurology},
  year    = {2011},
  doi     = {10.1212/wnl.0b013e318221acee},
  pmid    = {21593437},
  url     = {https://doi.org/10.1212/wnl.0b013e318221acee}
}

@article{hu2010-21092856,
  author  = {Hu, F. and Padukkavidana, T. and Vægter, C. B. and Brady, O. A. and Zheng, Y. and Mackenzie, I. R. and Feldman, H. H. and Nykjaer, A. and others},
  title   = {{Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin}},
  journal = {Neuron},
  year    = {2010},
  doi     = {10.1016/j.neuron.2010.09.034},
  pmid    = {21092856},
  url     = {https://doi.org/10.1016/j.neuron.2010.09.034}
}

@article{mckee2010-20720505,
  author  = {McKee, A. C. and Gavett, B. E. and Stern, R. A. and Nowinski, C. J. and Cantu, R. C. and Kowall, N. W. and Perl, D. P. and Hedley-Whyte, E. T. and others},
  title   = {{TDP-43 proteinopathy and motor neuron disease in chronic traumatic encephalopathy}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2010},
  doi     = {10.1097/nen.0b013e3181ee7d85},
  pmid    = {20720505},
  url     = {https://doi.org/10.1097/nen.0b013e3181ee7d85}
}

@article{xu2010-20702714,
  author  = {Xu, Y. F. and Gendron, T. F. and Zhang, Y. J. and Lin, W. L. and D'Alton, S. and Sheng, H. and Casey, M. C. and Tong, J. and others},
  title   = {{Wild-type human TDP-43 expression causes TDP-43 phosphorylation, mitochondrial aggregation, motor deficits, and early mortality in transgenic mice}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2010},
  doi     = {10.1523/jneurosci.1630-10.2010},
  pmid    = {20702714},
  url     = {https://doi.org/10.1523/jneurosci.1630-10.2010}
}

@article{dormann2010-20606625,
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  title   = {{ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import}},
  journal = {The EMBO journal},
  year    = {2010},
  doi     = {10.1038/emboj.2010.143},
  pmid    = {20606625},
  url     = {https://doi.org/10.1038/emboj.2010.143}
}

@article{schulzschaeffer2010-20563819,
  author  = {Schulz-Schaeffer, W. J.},
  title   = {{The synaptic pathology of alpha-synuclein aggregation in dementia with Lewy bodies, Parkinson's disease and Parkinson's disease dementia}},
  journal = {Acta neuropathologica},
  year    = {2010},
  doi     = {10.1007/s00401-010-0711-0},
  pmid    = {20563819},
  url     = {https://doi.org/10.1007/s00401-010-0711-0}
}

@article{urwin2010-20490813,
  author  = {Urwin, H. and Josephs, K. A. and Rohrer, J. D. and Mackenzie, I. R. and Neumann, M. and Authier, A. and Seelaar, H. and Van Swieten, J. C. and others},
  title   = {{FUS pathology defines the majority of tau- and TDP-43-negative frontotemporal lobar degeneration}},
  journal = {Acta neuropathologica},
  year    = {2010},
  doi     = {10.1007/s00401-010-0698-6},
  pmid    = {20490813},
  url     = {https://doi.org/10.1007/s00401-010-0698-6}
}

@article{clinton2010-20505094,
  author  = {Clinton, L. K. and Blurton-Jones, M. and Myczek, K. and Trojanowski, J. Q. and LaFerla, F. M.},
  title   = {{Synergistic Interactions between Abeta, tau, and alpha-synuclein: acceleration of neuropathology and cognitive decline}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2010},
  doi     = {10.1523/jneurosci.0490-10.2010},
  pmid    = {20505094},
  url     = {https://doi.org/10.1523/jneurosci.0490-10.2010}
}

@article{mckee2009-19535999,
  author  = {McKee, A. C. and Cantu, R. C. and Nowinski, C. J. and Hedley-Whyte, E. T. and Gavett, B. E. and Budson, A. E. and Santini, V. E. and Lee, H. S. and others},
  title   = {{Chronic traumatic encephalopathy in athletes: progressive tauopathy after repetitive head injury}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2009},
  doi     = {10.1097/nen.0b013e3181a9d503},
  pmid    = {19535999},
  url     = {https://doi.org/10.1097/nen.0b013e3181a9d503}
}

@article{johnson2009-19465477,
  author  = {Johnson, B. S. and Snead, D. and Lee, J. J. and McCaffery, J. M. and Shorter, J. and Gitler, A. D.},
  title   = {{TDP-43 is intrinsically aggregation-prone, and amyotrophic lateral sclerosis-linked mutations accelerate aggregation and increase toxicity}},
  journal = {The Journal of biological chemistry},
  year    = {2009},
  doi     = {10.1074/jbc.m109.010264},
  pmid    = {19465477},
  url     = {https://doi.org/10.1074/jbc.m109.010264}
}

@article{lace2009-19321462,
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  title   = {{Hippocampal tau pathology is related to neuroanatomical connections: an ageing population-based study}},
  journal = {Brain : a journal of neurology},
  year    = {2009},
  doi     = {10.1093/brain/awp059},
  pmid    = {19321462},
  url     = {https://doi.org/10.1093/brain/awp059}
}

@article{qin2009-19273754,
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  title   = {{PGC-1alpha expression decreases in the Alzheimer disease brain as a function of dementia}},
  journal = {Archives of neurology},
  year    = {2009},
  doi     = {10.1001/archneurol.2008.588},
  pmid    = {19273754},
  url     = {https://doi.org/10.1001/archneurol.2008.588}
}

@article{okello2009-19122031,
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  title   = {{Microglial activation and amyloid deposition in mild cognitive impairment: a PET study}},
  journal = {Neurology},
  year    = {2009},
  doi     = {10.1212/01.wnl.0000338622.27876.0d},
  pmid    = {19122031},
  url     = {https://doi.org/10.1212/01.wnl.0000338622.27876.0d}
}

@article{kantarci2008-19064749,
  author  = {Kantarci, K. and Petersen, R. C. and Przybelski, S. A. and Weigand, S. D. and Shiung, M. M. and Whitwell, J. L. and Negash, S. and Ivnik, R. J. and others},
  title   = {{Hippocampal volumes, proton magnetic resonance spectroscopy metabolites, and cerebrovascular disease in mild cognitive impairment subtypes}},
  journal = {Archives of neurology},
  year    = {2008},
  doi     = {10.1001/archneur.65.12.1621},
  pmid    = {19064749},
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}

@article{gregory2008-18799783,
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  title   = {{Neurodegeneration associated with genetic defects in phospholipase A(2)}},
  journal = {Neurology},
  year    = {2008},
  doi     = {10.1212/01.wnl.0000327094.67726.28},
  pmid    = {18799783},
  url     = {https://doi.org/10.1212/01.wnl.0000327094.67726.28}
}

@article{piccio2008-18790823,
  author  = {Piccio, Laura M. and Buonsanti, Cecilia and Cella, Marina and Tassi, Ilaria and Schmidt, Robert E. and Fenoglio, Chiara and Rinker, John Robert and Naismith, Robert T. and Panina‐Bordignon, Paola and Passini, Nadia and Galimberti, Daniela and Scarpini, Elio Angelo and Colonna, Marco and Cross, Anne Haney},
  title   = {{Identification of soluble TREM-2 in the cerebrospinal fluid and its association with multiple sclerosis and CNS inflammation}},
  journal = {Brain},
  year    = {2008},
  doi     = {10.1093/brain/awn217},
  pmid    = {18790823},
  url     = {https://doi.org/10.1093/brain/awn217}
}

@article{whitwell2008-18765650,
  author  = {Whitwell, J. L. and Josephs, K. A. and Murray, M. E. and Kantarci, K. and Przybelski, S. A. and Weigand, S. D. and Vemuri, P. and Senjem, M. L. and others},
  title   = {{MRI correlates of neurofibrillary tangle pathology at autopsy: a voxel-based morphometry study}},
  journal = {Neurology},
  year    = {2008},
  doi     = {10.1212/01.wnl.0000324924.91351.7d},
  pmid    = {18765650},
  url     = {https://doi.org/10.1212/01.wnl.0000324924.91351.7d}
}

@article{bian2008-18458217,
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  title   = {{CSF biomarkers in frontotemporal lobar degeneration with known pathology}},
  journal = {Neurology},
  year    = {2008},
  doi     = {10.1212/01.wnl.0000311445.21321.fc},
  pmid    = {18458217},
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}

@article{bombois2008-18436882,
  author  = {Bombois, S. and Debette, S. and Bruandet, A. and Delbeuck, X. and Delmaire, C. and Leys, D. and Pasquier, F.},
  title   = {{Vascular subcortical hyperintensities predict conversion to vascular and mixed dementia in MCI patients}},
  journal = {Stroke},
  year    = {2008},
  doi     = {10.1161/strokeaha.107.505206},
  pmid    = {18436882},
  url     = {https://doi.org/10.1161/strokeaha.107.505206}
}

@article{winton2008-18305110,
  author  = {Winton, M. J. and Igaz, L. M. and Wong, M. M. and Kwong, L. K. and Trojanowski, J. Q. and Lee, V. M.},
  title   = {{Disturbance of nuclear and cytoplasmic TAR DNA-binding protein (TDP-43) induces disease-like redistribution, sequestration, and aggregate formation}},
  journal = {The Journal of biological chemistry},
  year    = {2008},
  doi     = {10.1074/jbc.m800342200},
  pmid    = {18305110},
  url     = {https://doi.org/10.1074/jbc.m800342200}
}

@article{chetelat2008-18289618,
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  title   = {{Three-dimensional surface mapping of hippocampal atrophy progression from MCI to AD and over normal aging as assessed using voxel-based morphometry}},
  journal = {Neuropsychologia},
  year    = {2008},
  doi     = {10.1016/j.neuropsychologia.2007.11.037},
  pmid    = {18289618},
  url     = {https://doi.org/10.1016/j.neuropsychologia.2007.11.037}
}

@article{zhang2007-17898224,
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  title   = {{Progranulin mediates caspase-dependent cleavage of TAR DNA binding protein-43}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2007},
  doi     = {10.1523/jneurosci.3421-07.2007},
  pmid    = {17898224},
  url     = {https://doi.org/10.1523/jneurosci.3421-07.2007}
}

@article{braak2006-17078043,
  author  = {Braak, H. and Bohl, JR. and Müller, C. M. and Rüb, U. and de Vos, R. A. and Del Tredici, K.},
  title   = {{Stanley Fahn Lecture 2005: The staging procedure for the inclusion body pathology associated with sporadic Parkinson's disease reconsidered}},
  journal = {Movement disorders : official journal of the Movement Disorder Society},
  year    = {2006},
  doi     = {10.1002/mds.21065},
  pmid    = {17078043},
  url     = {https://doi.org/10.1002/mds.21065}
}

@article{turnbull2006-16951310,
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  title   = {{Cutting Edge: TREM-2 Attenuates Macrophage Activation}},
  journal = {The Journal of Immunology},
  year    = {2006},
  doi     = {10.4049/jimmunol.177.6.3520},
  pmid    = {16951310},
  url     = {https://doi.org/10.4049/jimmunol.177.6.3520}
}

@article{hamerman2006-16887962,
  author  = {Hamerman, Jessica A. and Jarjoura, Jessica R and Humphrey, Mary Beth and Nakamura, Mary C. and Seaman, William E. and Lanier, Lewis L.},
  title   = {{Cutting Edge: Inhibition of TLR and FcR Responses in Macrophages by Triggering Receptor Expressed on Myeloid Cells (TREM)-2 and DAP12}},
  journal = {The Journal of Immunology},
  year    = {2006},
  doi     = {10.4049/jimmunol.177.4.2051},
  pmid    = {16887962},
  url     = {https://doi.org/10.4049/jimmunol.177.4.2051}
}

@article{velakoulis2006-16461856,
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  title   = {{Hippocampal and amygdala volumes according to psychosis stage and diagnosis: a magnetic resonance imaging study of chronic schizophrenia, first-episode psychosis, and ultra-high-risk individuals}},
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  year    = {2006},
  doi     = {10.1001/archpsyc.63.2.139},
  pmid    = {16461856},
  url     = {https://doi.org/10.1001/archpsyc.63.2.139}
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@article{bartzokis2006-16389198,
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  title   = {{Apolipoprotein E genotype and age-related myelin breakdown in healthy individuals: implications for cognitive decline and dementia}},
  journal = {Archives of general psychiatry},
  year    = {2006},
  doi     = {10.1001/archpsyc.63.1.63},
  pmid    = {16389198},
  url     = {https://doi.org/10.1001/archpsyc.63.1.63}
}

@article{martin2006-16399671,
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  title   = {{Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2006},
  doi     = {10.1523/jneurosci.4308-05.2006},
  pmid    = {16399671},
  url     = {https://doi.org/10.1523/jneurosci.4308-05.2006}
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@article{beacher2005-16330724,
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  title   = {{Hippocampal myo-inositol and cognitive ability in adults with Down syndrome: an in vivo proton magnetic resonance spectroscopy study}},
  journal = {Archives of general psychiatry},
  year    = {2005},
  doi     = {10.1001/archpsyc.62.12.1360},
  pmid    = {16330724},
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@article{tangwai2004-15477533,
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  title   = {{Clinical, genetic, and neuropathologic characteristics of posterior cortical atrophy}},
  journal = {Neurology},
  year    = {2004},
  doi     = {10.1212/01.wnl.0000140289.18472.15},
  pmid    = {15477533},
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@article{du2004-14872024,
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  title   = {{Higher atrophy rate of entorhinal cortex than hippocampus in AD}},
  journal = {Neurology},
  year    = {2004},
  doi     = {10.1212/01.wnl.0000106462.72282.90},
  pmid    = {14872024},
  url     = {https://doi.org/10.1212/01.wnl.0000106462.72282.90}
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@article{rodrigue2004-14749440,
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  title   = {{Shrinkage of the entorhinal cortex over five years predicts memory performance in healthy adults}},
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  year    = {2004},
  doi     = {10.1523/jneurosci.4166-03.2004},
  pmid    = {14749440},
  url     = {https://doi.org/10.1523/jneurosci.4166-03.2004}
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@article{leissring2003-14687544,
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  title   = {{Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death}},
  journal = {Neuron},
  year    = {2003},
  doi     = {10.1016/s0896-6273(03)00787-6},
  pmid    = {14687544},
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@article{rosso2003-12975285,
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  title   = {{Total tau and phosphorylated tau 181 levels in the cerebrospinal fluid of patients with frontotemporal dementia due to P301L and G272V tau mutations}},
  journal = {Archives of neurology},
  year    = {2003},
  doi     = {10.1001/archneur.60.9.1209},
  pmid    = {12975285},
  url     = {https://doi.org/10.1001/archneur.60.9.1209}
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@article{wysscoray2003-12612547,
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  title   = {{Adult mouse astrocytes degrade amyloid-β in vitro and in situ}},
  journal = {Nature Medicine},
  year    = {2003},
  doi     = {10.1038/nm838},
  pmid    = {12612547},
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@article{dickson2002-12430710,
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  title   = {{Office of Rare Diseases neuropathologic criteria for corticobasal degeneration}},
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  year    = {2002},
  doi     = {10.1093/jnen/61.11.935},
  pmid    = {12430710},
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@article{allen2002-12417659,
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  title   = {{Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301S tau protein}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2002},
  doi     = {10.1523/jneurosci.22-21-09340.2002},
  pmid    = {12417659},
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@article{paloneva2002-12080485,
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  title   = {{Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype}},
  journal = {American journal of human genetics},
  year    = {2002},
  doi     = {10.1086/342259},
  pmid    = {12080485},
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@article{li2002-11875758,
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  title   = {{Age at onset in two common neurodegenerative diseases is genetically controlled}},
  journal = {American journal of human genetics},
  year    = {2002},
  doi     = {10.1086/339815},
  pmid    = {11875758},
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@article{apaydin2002-11790237,
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  title   = {{Parkinson disease neuropathology: later-developing dementia and loss of the levodopa response}},
  journal = {Archives of neurology},
  year    = {2002},
  doi     = {10.1001/archneur.59.1.102},
  pmid    = {11790237},
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@article{masliah2001-11572944,
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  title   = {{beta-amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease}},
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  year    = {2001},
  doi     = {10.1073/pnas.211412398},
  pmid    = {11572944},
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  title   = {{Loss-of-function mutations in TYROBP (DAP12) result in a presenile dementia with bone cysts}},
  journal = {Nature genetics},
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  title   = {{Childhood adversity heightens the impact of later-life caregiving stress on telomere length and inflammation}},
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  title   = {{Motor and cognitive outcome in patients with Parkinson's disease 8 years after subthalamic implants}},
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  title   = {{The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1}},
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  title   = {{Hypoxia-inducible factor 1alpha (HIF-1alpha)-mediated hypoxia increases BACE1 expression and beta-amyloid generation}},
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  title   = {{Phenotypic variation in a large Swedish pedigree due to SNCA duplication and triplication}},
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  title   = {{Progression of tremor and ataxia in male carriers of the FMR1 premutation}},
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  title   = {{Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction}},
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  title   = {{Diffusion magnetic resonance histograms as a surrogate marker and predictor of disease progression in CADASIL: a two-year follow-up study}},
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  title   = {{Medial temporal lobe atrophy and white matter hyperintensities are associated with mild cognitive deficits in non-disabled elderly people: the LADIS study}},
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@article{tupler2006-16199014,
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  year    = {2006},
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  pmid    = {39819375},
  url     = {https://doi.org/10.1186/s13148-025-01815-1}
}

@article{assogna2025-40046339,
  author  = {Assogna, Martina and Di Lorenzo, Francesco and Bonnı̀, Sonia and Borghi, Ilaria and Irelli, Emanuele Cerulli and Mencarelli, Lucia and Maiella, Michele and Minei, Marilena and others},
  title   = {{Phase 2 study of palmitoylethanolamide combined with luteoline in frontotemporal dementia patients}},
  journal = {Brain Communications},
  year    = {2025},
  doi     = {10.1093/braincomms/fcaf080},
  pmid    = {40046339},
  url     = {https://doi.org/10.1093/braincomms/fcaf080}
}

@article{vilortejedor2025-41092763,
  author  = {Vilor‐Tejedor, Natàlia and Rodrigo, Albert and Genius, Patricia and Rodríguez‐Fernández, Blanca and Anastasi, Federica and Pelkmans, Wiesje and Navarro, Arcadi and Adams, Hieab H.H. and others},
  title   = {{Genetic drivers of hippocampal atrophy highlight the role of APOE functional variants and AD polygenicity in Mild Cognitive Impairment}},
  journal = {NeuroImage Clinical},
  year    = {2025},
  doi     = {10.1016/j.nicl.2025.103889},
  pmid    = {41092763},
  url     = {https://doi.org/10.1016/j.nicl.2025.103889}
}

@article{deboer2025-40486666,
  author  = {de Boer, Sterre C.M. and Fenoglio, Chiara and Arighi, Andrea and Wissink, Lisa and Riedl, Lina and Rue, Ishana and Landín-Romero, Ramón and Matis, Sophie and others},
  title   = {{Serum neurofilament light is superior to glial fibrillary acidic protein to distinguish sporadic frontotemporal dementia from late-onset primary psychiatric disorders: a retrospective DIPPA-FTD study}},
  journal = {BMJ Neurology Open},
  year    = {2025},
  doi     = {10.1136/bmjno-2024-001007},
  pmid    = {40486666},
  url     = {https://doi.org/10.1136/bmjno-2024-001007}
}

@article{duggan2024-39143319,
  author  = {Duggan, M. R. and Peng, Z. and Sipilä, P. N. and Lindbohm, J. V. and Chen, J. and Lu, Y. and Davatzikos, C. and Erus, G. and others},
  title   = {{Proteomics identifies potential immunological drivers of postinfection brain atrophy and cognitive decline}},
  journal = {Nature aging},
  year    = {2024},
  doi     = {10.1038/s43587-024-00682-4},
  pmid    = {39143319},
  url     = {https://doi.org/10.1038/s43587-024-00682-4}
}

@article{guimaraes2024-38972873,
  author  = {Guimarães, G. R. and Maklouf, G. R. and Teixeira, C. E. and de Oliveira Santos, L. and Tessarollo, N. G. and de Toledo, N. E. and Serain, A. F. and de Lanna, C. A. and others},
  title   = {{Single-cell resolution characterization of myeloid-derived cell states with implication in cancer outcome}},
  journal = {Nature communications},
  year    = {2024},
  doi     = {10.1038/s41467-024-49916-4},
  pmid    = {38972873},
  url     = {https://doi.org/10.1038/s41467-024-49916-4}
}

@article{coley2024-38310892,
  author  = {Coley, N. and Zetterberg, H. and Cantet, C. and Guyonnet, S. and Ashton, N. J. and Vellas, B. and Blennow, K. and Andrieu, S. and others},
  title   = {{Plasma p-tau181 as an outcome and predictor of multidomain intervention effects: a secondary analysis of a randomised, controlled, dementia prevention trial}},
  journal = {The lancet. Healthy longevity},
  year    = {2024},
  doi     = {10.1016/s2666-7568(23)00255-6},
  pmid    = {38310892},
  url     = {https://doi.org/10.1016/s2666-7568(23)00255-6}
}

@article{yu2024-38289348,
  author  = {Yu, C. and Lad, E. M. and Mathew, R. and Shiraki, N. and Littleton, S. and Chen, Y. and Hou, J. and Schlepckow, K. and others},
  title   = {{Microglia at sites of atrophy restrict the progression of retinal degeneration via galectin-3 and Trem2}},
  journal = {The Journal of experimental medicine},
  year    = {2024},
  doi     = {10.1084/jem.20231011},
  pmid    = {38289348},
  url     = {https://doi.org/10.1084/jem.20231011}
}

@article{dzobo2024-38269588,
  author  = {Dzobo, K. E. and Cupido, A. J. and Mol, B. M. and Stiekema, L. C. A. and Versloot, M. and Winkelmeijer, M. and Peter, J. and Pennekamp, A. M. and others},
  title   = {{Diacylglycerols and Lysophosphatidic Acid, Enriched on Lipoprotein(a), Contribute to Monocyte Inflammation}},
  journal = {Arteriosclerosis, thrombosis, and vascular biology},
  year    = {2024},
  doi     = {10.1161/atvbaha.123.319937},
  pmid    = {38269588},
  url     = {https://doi.org/10.1161/atvbaha.123.319937}
}

@article{gong2024-38182899,
  author  = {Gong, S. and Zhai, M. and Shi, J. and Yu, G. and Lei, Z. and Shi, Y. and Zeng, Y. and Ju, P. and others},
  title   = {{TREM2 macrophage promotes cardiac repair in myocardial infarction by reprogramming metabolism via SLC25A53}},
  journal = {Cell death and differentiation},
  year    = {2024},
  doi     = {10.1038/s41418-023-01252-8},
  pmid    = {38182899},
  url     = {https://doi.org/10.1038/s41418-023-01252-8}
}

@article{kim2024-38669527,
  author  = {Kim, D. and Jamrasi, P. and Li, X. and Ahn, S. and Sung, Y. and Kang, Y. and Song, W.},
  title   = {{Effects of Exercise on Urinary AD7c-NTP (Alzheimer-Associated Neuronal Thread Protein) Levels and Cognitive Function Among Active Korean Elderly: A Randomized Controlled Trial}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2024},
  doi     = {10.3233/jad-230946},
  pmid    = {38669527},
  url     = {https://doi.org/10.3233/jad-230946}
}

@article{he2023-38017580,
  author  = {He, K. Y. and Khramtsova, E. A. and Cabrera-Socorro, A. and Zhang, Y. and Li, S. and Sarver, B. A. J. and Smets, B. and Li, Q. S. and De Muynck, L. and Parrado, A. R. and Lovestone, S. and Black, M. H.},
  title   = {{Characterization of APOE Christchurch carriers in 455,306 UK Biobank participants}},
  journal = {Molecular Neurodegeneration},
  year    = {2023},
  doi     = {10.1186/s13024-023-00684-7},
  pmid    = {38017580},
  url     = {https://doi.org/10.1186/s13024-023-00684-7}
}

@article{zheng2024-37837382,
  author  = {Zheng, L. and Rubinski, A. and Denecke, J. and Luan, Y. and Smith, R. and Strandberg, O. and Stomrud, E. and Ossenkoppele, R. and others},
  title   = {{Combined Connectomics, MAPT Gene Expression, and Amyloid Deposition to Explain Regional Tau Deposition in Alzheimer Disease}},
  journal = {Annals of neurology},
  year    = {2024},
  doi     = {10.1002/ana.26818},
  pmid    = {37837382},
  url     = {https://doi.org/10.1002/ana.26818}
}

@article{yoo2023-37541210,
  author  = {Yoo, Y. and Neumayer, G. and Shibuya, Y. and Mader, M. M. and Wernig, M.},
  title   = {{A cell therapy approach to restore microglial Trem2 function in a mouse model of Alzheimer's disease}},
  journal = {Cell stem cell},
  year    = {2023},
  doi     = {10.1016/j.stem.2023.07.006},
  pmid    = {37541210},
  url     = {https://doi.org/10.1016/j.stem.2023.07.006}
}

@article{zhong2023-37442133,
  author  = {Zhong, L. and Sheng, X. and Wang, W. and Li, Y. and Zhuo, R. and Wang, K. and Zhang, L. and Hu, D. D. and others},
  title   = {{TREM2 receptor protects against complement-mediated synaptic loss by binding to complement C1q during neurodegeneration}},
  journal = {Immunity},
  year    = {2023},
  doi     = {10.1016/j.immuni.2023.06.016},
  pmid    = {37442133},
  url     = {https://doi.org/10.1016/j.immuni.2023.06.016}
}

@article{sun2023-37172094,
  author  = {Sun, R. and Han, R. and McCornack, C. and Khan, S. and Tabor, G. T. and Chen, Y. and Hou, J. and Jiang, H. and others},
  title   = {{TREM2 inhibition triggers antitumor cell activity of myeloid cells in glioblastoma}},
  journal = {Science advances},
  year    = {2023},
  doi     = {10.1126/sciadv.ade3559},
  pmid    = {37172094},
  url     = {https://doi.org/10.1126/sciadv.ade3559}
}

@article{parhizkar2023-37099634,
  author  = {Parhizkar, S. and Gent, G. and Chen, Y. and Rensing, N. and Gratuze, M. and Strout, G. and Sviben, S. and Tycksen, E. and others},
  title   = {{Sleep deprivation exacerbates microglial reactivity and Aβ deposition in a TREM2-dependent manner in mice}},
  journal = {Science translational medicine},
  year    = {2023},
  doi     = {10.1126/scitranslmed.ade6285},
  pmid    = {37099634},
  url     = {https://doi.org/10.1126/scitranslmed.ade6285}
}

@article{conte2023-37189346,
  author  = {Conte, M. and De Feo, M. S. and Corica, F. and Gorica, J. and Sidrak, M. M. A. and De Cristofaro, F. and Filippi, L. and Ricci, M. and others},
  title   = {{A Systematic Review on Dementia and Translocator Protein (TSPO): When Nuclear Medicine Highlights an Underlying Expression}},
  journal = {Biomolecules},
  year    = {2023},
  doi     = {10.3390/biom13040598},
  pmid    = {37189346},
  url     = {https://doi.org/10.3390/biom13040598}
}

@article{bancaro2023-36868226,
  author  = {Bancaro, N. and Calì, B. and Troiani, M. and Elia, A. R. and Arzola, R. A. and Attanasio, G. and Lai, P. and Crespo, M. and others},
  title   = {{Apolipoprotein E induces pathogenic senescent-like myeloid cells in prostate cancer}},
  journal = {Cancer cell},
  year    = {2023},
  doi     = {10.1016/j.ccell.2023.02.004},
  pmid    = {36868226},
  url     = {https://doi.org/10.1016/j.ccell.2023.02.004}
}

@article{giudici2023-36508390,
  author  = {Giudici, K. V. and de Souto Barreto, P. and Guyonnet, S. and Morley, J. E. and Nguyen, A. D. and Aggarwal, G. and Parini, A. and Li, Y. and others},
  title   = {{TNFR-1 and GDF-15 Are Associated With Plasma Neurofilament Light Chain and Progranulin Among Community-Dwelling Older Adults: A Secondary Analysis of the MAPT Study}},
  journal = {The journals of gerontology. Series A, Biological sciences and medical sciences},
  year    = {2023},
  doi     = {10.1093/gerona/glac244},
  pmid    = {36508390},
  url     = {https://doi.org/10.1093/gerona/glac244}
}

@article{brandebura2023-36316501,
  author  = {Brandebura, A. N. and Paumier, A. and Onur, T. S. and Allen, N. J.},
  title   = {{Astrocyte contribution to dysfunction, risk and progression in neurodegenerative disorders}},
  journal = {Nature reviews. Neuroscience},
  year    = {2023},
  doi     = {10.1038/s41583-022-00641-1},
  pmid    = {36316501},
  url     = {https://doi.org/10.1038/s41583-022-00641-1}
}

@article{saunders2022-36041266,
  author  = {Saunders, T. S. and Jenkins, N. and Blennow, K. and Ritchie, C. and Muniz-Terrera, G.},
  title   = {{Interactions between apolipoprotein E, sex, and amyloid-beta on cerebrospinal fluid p-tau levels in the European prevention of Alzheimer's dementia longitudinal cohort study (EPAD LCS)}},
  journal = {EBioMedicine},
  year    = {2022},
  doi     = {10.1016/j.ebiom.2022.104241},
  pmid    = {36041266},
  url     = {https://doi.org/10.1016/j.ebiom.2022.104241}
}

@article{hendrikx2022-35750138,
  author  = {Hendrikx, T. and Porsch, F. and Kiss, M. G. and Rajcic, D. and Papac-Miličević, N. and Hoebinger, C. and Goederle, L. and Hladik, A. and others},
  title   = {{Soluble TREM2 levels reflect the recruitment and expansion of TREM2+ macrophages that localize to fibrotic areas and limit NASH}},
  journal = {Journal of hepatology},
  year    = {2022},
  doi     = {10.1016/j.jhep.2022.06.004},
  pmid    = {35750138},
  url     = {https://doi.org/10.1016/j.jhep.2022.06.004}
}

@article{li2022-35658903,
  author  = {Li, R. Y. and Qin, Q. and Yang, H. C. and Wang, Y. Y. and Mi, Y. X. and Yin, Y. S. and Wang, M. and Yu, C. J. and others},
  title   = {{TREM2 in the pathogenesis of AD: a lipid metabolism regulator and potential metabolic therapeutic target}},
  journal = {Molecular neurodegeneration},
  year    = {2022},
  doi     = {10.1186/s13024-022-00542-y},
  pmid    = {35658903},
  url     = {https://doi.org/10.1186/s13024-022-00542-y}
}

@article{heshmatollah2022-35232820,
  author  = {Heshmatollah, A. and Fani, L. and Koudstaal, P. J. and Ghanbari, M. and Ikram, M. A. and Ikram, M. K.},
  title   = {{Plasma β-Amyloid, Total-Tau, and Neurofilament Light Chain Levels and the Risk of Stroke: A Prospective Population-Based Study}},
  journal = {Neurology},
  year    = {2022},
  doi     = {10.1212/wnl.0000000000200004},
  pmid    = {35232820},
  url     = {https://doi.org/10.1212/wnl.0000000000200004}
}

@article{filipello2022-35041990,
  author  = {Filipello, F. and Goldsbury, C. and You, S. F. and Locca, A. and Karch, C. M. and Piccio, L.},
  title   = {{Soluble TREM2: Innocent bystander or active player in neurological diseases?}},
  journal = {Neurobiology of disease},
  year    = {2022},
  doi     = {10.1016/j.nbd.2022.105630},
  pmid    = {35041990},
  url     = {https://doi.org/10.1016/j.nbd.2022.105630}
}

@article{reifschneider2022-35019161,
  author  = {Reifschneider, A. and Robinson, S. and van Lengerich, B. and Gnörich, J. and Logan, T. and Heindl, S. and Vogt, M. A. and Weidinger, E. and others},
  title   = {{Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency}},
  journal = {The EMBO journal},
  year    = {2022},
  doi     = {10.15252/embj.2021109108},
  pmid    = {35019161},
  url     = {https://doi.org/10.15252/embj.2021109108}
}

@article{marriott2022-34978125,
  author  = {Marriott, R. J. and Murray, K. and Flicker, L. and Hankey, G. J. and Matsumoto, A. M. and Dwivedi, G. and Antonio, L. and Almeida, O. P. and others},
  title   = {{Lower serum testosterone concentrations are associated with a higher incidence of dementia in men: The UK Biobank prospective cohort study}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2022},
  doi     = {10.1002/alz.12529},
  pmid    = {34978125},
  url     = {https://doi.org/10.1002/alz.12529}
}

@article{malik2021-34626176,
  author  = {Malik, R. and Beaufort, N. and Frerich, S. and Gesierich, B. and Georgakis, M. K. and Rannikmäe, K. and Ferguson, A. C. and Haffner, C. and others},
  title   = {{Whole-exome sequencing reveals a role of HTRA1 and EGFL8 in brain white matter hyperintensities}},
  journal = {Brain : a journal of neurology},
  year    = {2021},
  doi     = {10.1093/brain/awab253},
  pmid    = {34626176},
  url     = {https://doi.org/10.1093/brain/awab253}
}

@article{zhao2021-34530866,
  author  = {Zhao, Y. and Zhang, J. and Zheng, Y. and Zhang, Y. and Zhang, X. J. and Wang, H. and Du, Y. and Guan, J. and others},
  title   = {{NAD+ improves cognitive function and reduces neuroinflammation by ameliorating mitochondrial damage and decreasing ROS production in chronic cerebral hypoperfusion models through Sirt1/PGC-1α pathway}},
  journal = {Journal of neuroinflammation},
  year    = {2021},
  doi     = {10.1186/s12974-021-02250-8},
  pmid    = {34530866},
  url     = {https://doi.org/10.1186/s12974-021-02250-8}
}

@article{zhang2021-34363732,
  author  = {Zhang, W. B. and Ye, K. and Barzilai, N. and Milman, S.},
  title   = {{The antagonistic pleiotropy of insulin-like growth factor 1}},
  journal = {Aging cell},
  year    = {2021},
  doi     = {10.1111/acel.13443},
  pmid    = {34363732},
  url     = {https://doi.org/10.1111/acel.13443}
}

@article{ardighieri2021-34220848,
  author  = {Ardighieri, L. and Missale, F. and Bugatti, M. and Gatta, L. B. and Pezzali, I. and Monti, M. and Gottardi, S. and Zanotti, L. and others},
  title   = {{Infiltration by CXCL10 Secreting Macrophages Is Associated With Antitumor Immunity and Response to Therapy in Ovarian Cancer Subtypes}},
  journal = {Frontiers in immunology},
  year    = {2021},
  doi     = {10.3389/fimmu.2021.690201},
  pmid    = {34220848},
  url     = {https://doi.org/10.3389/fimmu.2021.690201}
}

@article{fitz2021-34099706,
  author  = {Fitz, N. F. and Nam, K. N. and Wolfe, C. M. and Letronne, F. and Playso, B. E. and Iordanova, B. E. and Kozai, T. D. Y. and Biedrzycki, R. J. and others},
  title   = {{Phospholipids of APOE lipoproteins activate microglia in an isoform-specific manner in preclinical models of Alzheimer's disease}},
  journal = {Nature communications},
  year    = {2021},
  doi     = {10.1038/s41467-021-23762-0},
  pmid    = {34099706},
  url     = {https://doi.org/10.1038/s41467-021-23762-0}
}

@article{lee2021-33675684,
  author  = {Lee, S. H. and Meilandt, W. J. and Xie, L. and Gandham, V. D. and Ngu, H. and Barck, K. H. and Rezzonico, M. G. and Imperio, J. and others},
  title   = {{Trem2 restrains the enhancement of tau accumulation and neurodegeneration by β-amyloid pathology}},
  journal = {Neuron},
  year    = {2021},
  doi     = {10.1016/j.neuron.2021.02.010},
  pmid    = {33675684},
  url     = {https://doi.org/10.1016/j.neuron.2021.02.010}
}

@article{haller2021-33620291,
  author  = {Haller, S. and Haacke, E. M. and Thurnher, M. M. and Barkhof, F.},
  title   = {{Susceptibility-weighted Imaging: Technical Essentials and Clinical Neurologic Applications}},
  journal = {Radiology},
  year    = {2021},
  doi     = {10.1148/radiol.2021203071},
  pmid    = {33620291},
  url     = {https://doi.org/10.1148/radiol.2021203071}
}

@article{vilalta2021-33823153,
  author  = {Vilalta, A. and Zhou, Y. and Sevalle, J. and Griffin, J. K. and Satoh, K. and Allendorf, D. H. and De, S. and Puigdellívol, M. and others},
  title   = {{Wild-type sTREM2 blocks Aβ aggregation and neurotoxicity, but the Alzheimer's R47H mutant increases Aβ aggregation}},
  journal = {The Journal of biological chemistry},
  year    = {2021},
  doi     = {10.1016/j.jbc.2021.100631},
  pmid    = {33823153},
  url     = {https://doi.org/10.1016/j.jbc.2021.100631}
}

@article{propson2021-32990682,
  author  = {Propson, N. E. and Roy, E. R. and Litvinchuk, A. and Köhl, J. and Zheng, H.},
  title   = {{Endothelial C3a receptor mediates vascular inflammation and blood-brain barrier permeability during aging}},
  journal = {The Journal of clinical investigation},
  year    = {2021},
  doi     = {10.1172/jci140966},
  pmid    = {32990682},
  url     = {https://doi.org/10.1172/jci140966}
}

@article{liu2020-32959884,
  author  = {Liu, W. and Taso, O. and Wang, R. and Bayram, S. and Graham, A. C. and Garcia-Reitboeck, P. and Mallach, A. and Andrews, W. D. and others},
  title   = {{Trem2 promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions}},
  journal = {Human molecular genetics},
  year    = {2020},
  doi     = {10.1093/hmg/ddaa209},
  pmid    = {32959884},
  url     = {https://doi.org/10.1093/hmg/ddaa209}
}

@article{jo2020-33051572,
  author  = {Jo, M. and Lee, S. and Jeon, Y. M. and Kim, S. and Kwon, Y. and Kim, H. J.},
  title   = {{The role of TDP-43 propagation in neurodegenerative diseases: integrating insights from clinical and experimental studies}},
  journal = {Experimental \& molecular medicine},
  year    = {2020},
  doi     = {10.1038/s12276-020-00513-7},
  pmid    = {33051572},
  url     = {https://doi.org/10.1038/s12276-020-00513-7}
}

@article{cook2020-32878979,
  author  = {Cook, C. N. and Wu, Y. and Odeh, H. M. and Gendron, T. F. and Jansen-West, K. and Del Rosso, G. and Yue, M. and Jiang, P. and others},
  title   = {{C9orf72 poly(GR) aggregation induces TDP-43 proteinopathy}},
  journal = {Science translational medicine},
  year    = {2020},
  doi     = {10.1126/scitranslmed.abb3774},
  pmid    = {32878979},
  url     = {https://doi.org/10.1126/scitranslmed.abb3774}
}

@article{price2020-32795308,
  author  = {Price, B. R. and Sudduth, T. L. and Weekman, E. M. and Johnson, S. and Hawthorne, D. and Woolums, A. and Wilcock, D. M.},
  title   = {{Therapeutic Trem2 activation ameliorates amyloid-beta deposition and improves cognition in the 5XFAD model of amyloid deposition}},
  journal = {Journal of neuroinflammation},
  year    = {2020},
  doi     = {10.1186/s12974-020-01915-0},
  pmid    = {32795308},
  url     = {https://doi.org/10.1186/s12974-020-01915-0}
}

@article{rodriguezgomez2020-32709045,
  author  = {Rodríguez-Gómez, J. A. and Kavanagh, E. and Engskog-Vlachos, P. and Engskog, M. K. R. and Herrera, A. J. and Espinosa-Oliva, A. M. and Joseph, B. and Hajji, N. and others},
  title   = {{Microglia: Agents of the CNS Pro-Inflammatory Response}},
  journal = {Cells},
  year    = {2020},
  doi     = {10.3390/cells9071717},
  pmid    = {32709045},
  url     = {https://doi.org/10.3390/cells9071717}
}

@article{gomezbenito2020-32390826,
  author  = {Gómez-Benito, M. and Granado, N. and García-Sanz, P. and Michel, A. and Dumoulin, M. and Moratalla, R.},
  title   = {{Modeling Parkinson's Disease With the Alpha-Synuclein Protein}},
  journal = {Frontiers in pharmacology},
  year    = {2020},
  doi     = {10.3389/fphar.2020.00356},
  pmid    = {32390826},
  url     = {https://doi.org/10.3389/fphar.2020.00356}
}

@article{willemsen2020-32003464,
  author  = {Willemsen, L. and de Winther, M. P.},
  title   = {{Macrophage subsets in atherosclerosis as defined by single-cell technologies}},
  journal = {The Journal of pathology},
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  title   = {{The relation of dietary choline to cognitive performance and white-matter hyperintensity in the Framingham Offspring Cohort}},
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  title   = {{The diabetes drug liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease}},
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  title   = {{Surface-based TBM boosts power to detect disease effects on the brain: an N=804 ADNI study}},
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  title   = {{Association of TMEM106B gene polymorphism with age at onset in granulin mutation carriers and plasma granulin protein levels}},
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  title   = {{Gamma-secretase-dependent amyloid-beta is increased in Niemann-Pick type C: a cross-sectional study}},
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@article{ayala2011-21131904,
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  title   = {{TDP-43 regulates its mRNA levels through a negative feedback loop}},
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  title   = {{A novel Abeta isoform pattern in CSF reflects gamma-secretase inhibition in Alzheimer disease}},
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  title   = {{Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP disease}},
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  title   = {{TDP-43 is recruited to stress granules in conditions of oxidative insult}},
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  title   = {{Neural stem cells improve cognition via BDNF in a transgenic model of Alzheimer disease}},
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  title   = {{Vascular structure and function is correlated to cognitive performance and white matter hyperintensities in older hypertensive patients with subjective memory complaints}},
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  title   = {{Expression of TDP-43 C-terminal Fragments in Vitro Recapitulates Pathological Features of TDP-43 Proteinopathies}},
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  year    = {2009},
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  title   = {{Phosphorylated TDP-43 in Alzheimer's disease and dementia with Lewy bodies}},
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  title   = {{Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins}},
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  title   = {{TREM2 is upregulated in amyloid plaque-associated microglia in aged APP23 transgenic mice}},
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  title   = {{Periventricular white matter hyperintensities increase the likelihood of progression from amnestic mild cognitive impairment to dementia}},
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@article{rademakers2008-18723524,
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  title   = {{Common variation in the miR-659 binding-site of GRN is a major risk factor for TDP43-positive frontotemporal dementia}},
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@article{desikan2008-18672473,
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  title   = {{MRI measures of temporoparietal regions show differential rates of atrophy during prodromal AD}},
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  year    = {2008},
  doi     = {10.1212/01.wnl.0000320055.57329.34},
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@article{uryu2008-18520774,
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  title   = {{Concomitant TAR-DNA-binding protein 43 pathology is present in Alzheimer disease and corticobasal degeneration but not in other tauopathies}},
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}

@article{he2025-41366787,
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  title   = {{Development of language composites for enhanced sensitivity to multiple plasma biomarkers}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
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  pmid    = {41366787},
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}

@article{buonocore2025-41206819,
  author  = {Buonocore, Jolanda and Fratto, Enrico and Arcuri, Fulvia and Vescio, Basilio and Calomino, Camilla and Talarico, Mariagrazia and Cristiani, Costanza Maria and Quattrone, Aldo and others},
  title   = {{Plasma NfL and GFAP in the preclinical stages of neurodegenerative diseases: insights from the UK Biobank}},
  journal = {Journal of Neurology},
  year    = {2025},
  doi     = {10.1007/s00415-025-13498-y},
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}

@article{rotblatt2025-41104612,
  author  = {Rotblatt, Lindsay J. and Edwards, Lauren and Erani, Fareshte R. and Terao, Caitlin Marie and Bangen, Katherine J. and Thomas, Kelsey R.},
  title   = {{Impact of regional white matter hyperintensity patterns on cognitive trajectories in NACC}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz.70764},
  pmid    = {41104612},
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}

@article{yoo2025-40935607,
  author  = {Yoo, Hye Bin and Kang, Seung Kwan and Shin, Seong Ah and Kim, Daewoon and Choi, Hongyoon and Kim, Yoon‐Keun and Yi, Dahyun and Byun, Min Soo and others},
  title   = {{Artificial Intelligence–Powered Quantification of Flortaucipir PET for Detecting Tau Pathology}},
  journal = {Journal of Nuclear Medicine},
  year    = {2025},
  doi     = {10.2967/jnumed.125.269636},
  pmid    = {40935607},
  url     = {https://doi.org/10.2967/jnumed.125.269636}
}

@article{song2025-40902587,
  author  = {Song, Z. and Xie, X. and Chen, Y. and Zhang, B. and Li, X. and Yang, Y. and Mo, W. and Zhang, J. and Xu, D.},
  title   = {{Innate immune sensing of Z-nucleic acids by ZBP1-RIPK1 axis drives neuroinflammation in Alzheimer's disease}},
  journal = {Immunity},
  year    = {2025},
  doi     = {10.1016/j.immuni.2025.07.024},
  pmid    = {40902587},
  url     = {https://doi.org/10.1016/j.immuni.2025.07.024}
}

@article{oveisgharan2025-40845264,
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  title   = {{Cortical Gray Matter Proteins Associated With Cerebral Amyloid Angiopathy in Community-Dwelling Older Adults}},
  journal = {Neurology},
  year    = {2025},
  doi     = {10.1212/wnl.0000000000214024},
  pmid    = {40845264},
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}

@article{mastrangelo2025-40549179,
  author  = {Mastrangelo, Andrea and Caldera, Serena and Mastenbroek, Sophie E and Vittoriosi, Erica and Janelidze, Shorena and Serrano, Geidy E. and Atri, Alireza and Shill, Holly A. and others},
  title   = {{Quantification of Lewy body pathology by cerebrospinal fluid endpoint dilution RT-QuIC in a neuropathological autopsy cohort of clinically heterogeneous participants}},
  journal = {Acta Neuropathologica},
  year    = {2025},
  doi     = {10.1007/s00401-025-02904-4},
  pmid    = {40549179},
  url     = {https://doi.org/10.1007/s00401-025-02904-4}
}

@article{wang2025-40537069,
  author  = {Wang, Shuyue and Zhang, Fan and Zeng, Qingze and Hong, Hui and Zhang, Yao and Xie, Linyun and Miao, Lin and Jiaerken, Yeerfan and others},
  title   = {{Association of Superficial White Matter Microstructure With Cortical Pathology Deposition Across Early Stages of the AD Continuum}},
  journal = {Neurology},
  year    = {2025},
  doi     = {10.1212/wnl.0000000000213666},
  pmid    = {40537069},
  url     = {https://doi.org/10.1212/wnl.0000000000213666}
}

@article{bonham2025-40443531,
  author  = {Bonham, Luke W. and Sirkis, Daniel W. and Pang, Alina P.S. and Sugrue, Leo P. and Santamaría‐García, Hernando A and Ibáñez, Agustín M. and Miller, Bruce Leonard and Yokoyama, Jennifer S. and others},
  title   = {{DNA methylation age from peripheral blood predicts progression to Alzheimer’s disease, white matter disease burden, and cortical atrophy}},
  journal = {npj Dementia},
  year    = {2025},
  doi     = {10.1038/s44400-025-00007-1},
  pmid    = {40443531},
  url     = {https://doi.org/10.1038/s44400-025-00007-1}
}

@article{bellelli2025-40352263,
  author  = {Bellelli, Federico and Raffin, Jérémy and Angioni, Davide and Romana, Julie and Soto, María and Delrieu, Julien and Barreto, Philipe De Souto and {MAPT/DSA study group}},
  title   = {{The relationship between neurofilament light chain and depressive symptoms according to cognitive status}},
  journal = {Alzheimer s \& Dementia Translational Research \& Clinical Interventions},
  year    = {2025},
  doi     = {10.1002/trc2.70048},
  pmid    = {40352263},
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}

@article{jung2025-40149001,
  author  = {Jung, E. S. and Choi, H. and Mook-Jung, I.},
  title   = {{Decoding microglial immunometabolism: a new frontier in Alzheimer's disease research}},
  journal = {Molecular neurodegeneration},
  year    = {2025},
  doi     = {10.1186/s13024-025-00825-0},
  pmid    = {40149001},
  url     = {https://doi.org/10.1186/s13024-025-00825-0}
}

@article{mancini2025-40118834,
  author  = {Mancini, Martina and Afshari, Mitra and Almeida, Quincy J. and Huffmaster, Sommer L. Amundsen and Balfany, Katherine and Camicioli, Richard M. and Christiansen, Cory L. and Dale, Marian L. and others},
  title   = {{Digital gait biomarkers in Parkinson’s disease: susceptibility/risk, progression, response to exercise, and prognosis}},
  journal = {npj Parkinson s Disease},
  year    = {2025},
  doi     = {10.1038/s41531-025-00897-1},
  pmid    = {40118834},
  url     = {https://doi.org/10.1038/s41531-025-00897-1}
}

@article{bonomi2025-40112273,
  author  = {Bonomi, Chiara Giuseppina and Martorana, Alessandro and Motta, Caterina and Serafini, Chiara and Chiaravalloti, Agostino and Lauretti, Benedetta and Schillaci, Orazio and Mercuri, Nicola Biagio and others},
  title   = {{Autonomic Dysfunction in Patients With Dementia With Lewy Bodies and Its Relationship With Nigrostriatal Denervation}},
  journal = {Neurology},
  year    = {2025},
  doi     = {10.1212/wnl.0000000000213463},
  pmid    = {40112273},
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}

@article{martinezthompson2025-39820267,
  author  = {Martinez‐Thompson, Jennifer M. and Mazurek, Kevin A. and Cantu, Carolina Parra and Naddaf, Elie and Gogineni, Venkatsampath and Botha, Hugo and Jones, David Thomas and Laughlin, Ruple S. and others},
  title   = {{Artificial intelligence models using F-wave responses predict amyotrophic lateral sclerosis}},
  journal = {Brain},
  year    = {2025},
  doi     = {10.1093/brain/awaf014},
  pmid    = {39820267},
  url     = {https://doi.org/10.1093/brain/awaf014}
}

@article{goldstein2025-39817492,
  author  = {Goldstein, David S. and Alam, Parvez and Sullivan, Patti and Holmes, Courtney S. and Gelsomino, Janna and Hughson, Andrew G. and Caughey, Byron},
  title   = {{Elevated Cerebrospinal Fluid α‐Synuclein Seeding Activity Predicts Central Lewy Body Diseases}},
  journal = {Movement Disorders Clinical Practice},
  year    = {2025},
  doi     = {10.1002/mdc3.14333},
  pmid    = {39817492},
  url     = {https://doi.org/10.1002/mdc3.14333}
}

@article{jiang2024-38649866,
  author  = {Jiang, S. and Cai, G. and Yang, Z. and Shi, H. and Zeng, H. and Ye, Q. and Hu, Z. and Wang, Z.},
  title   = {{Biomimetic Nanovesicles as a Dual Gene Delivery System for the Synergistic Gene Therapy of Alzheimer's Disease}},
  journal = {ACS nano},
  year    = {2024},
  doi     = {10.1021/acsnano.3c13150},
  pmid    = {38649866},
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}

@article{fernandez2024-38553642,
  author  = {Fernandez, A. and Hoq, M. R. and Hallinan, G. I. and Li, D. and Bharath, SR. and Vago, F. S. and Zhang, X. and Ozcan, K. A. and others},
  title   = {{Cryo-EM structures of amyloid-β and tau filaments in Down syndrome}},
  journal = {Nature structural \& molecular biology},
  year    = {2024},
  doi     = {10.1038/s41594-024-01252-3},
  pmid    = {38553642},
  url     = {https://doi.org/10.1038/s41594-024-01252-3}
}

@article{yashaswini2024-38508241,
  author  = {Yashaswini, C. N. and Qin, T. and Bhattacharya, D. and Amor, C. and Lowe, S. and Lujambio, A. and Wang, S. and Friedman, S. L.},
  title   = {{Phenotypes and ontogeny of senescent hepatic stellate cells in metabolic dysfunction-associated steatohepatitis}},
  journal = {Journal of hepatology},
  year    = {2024},
  doi     = {10.1016/j.jhep.2024.03.014},
  pmid    = {38508241},
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}

@article{yofe2023-37756565,
  author  = {Yofe, I. and Shami, T. and Cohen, N. and Landsberger, T. and Sheban, F. and Stoler-Barak, L. and Yalin, A. and Phan, T. S. and others},
  title   = {{Spatial and Temporal Mapping of Breast Cancer Lung Metastases Identify TREM2 Macrophages as Regulators of the Metastatic Boundary}},
  journal = {Cancer discovery},
  year    = {2023},
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  pmid    = {37756565},
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}

@article{huang2024-37917301,
  author  = {Huang, P. and Zhang, Z. and Zhang, P. and Feng, J. and Xie, J. and Zheng, Y. and Liang, X. and Zhu, B. and others},
  title   = {{TREM2 Deficiency Aggravates NLRP3 Inflammasome Activation and Pyroptosis in MPTP-Induced Parkinson's Disease Mice and LPS-Induced BV2 Cells}},
  journal = {Molecular neurobiology},
  year    = {2024},
  doi     = {10.1007/s12035-023-03713-0},
  pmid    = {37917301},
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}

@article{patterson2023-38646596,
  author  = {Patterson, M. T. and Firulyova, M. M. and Xu, Y. and Hillman, H. and Bishop, C. and Zhu, A. and Hickok, G. H. and Schrank, P. R. and others},
  title   = {{Trem2 promotes foamy macrophage lipid uptake and survival in atherosclerosis}},
  journal = {Nature cardiovascular research},
  year    = {2023},
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}

@article{demuynck2024-37535809,
  author  = {De Muynck, K. and Heyerick, L. and De Ponti, F. F. and Vanderborght, B. and Meese, T. and Van Campenhout, S. and Baudonck, L. and Gijbels, E. and others},
  title   = {{Osteopontin characterizes bile duct-associated macrophages and correlates with liver fibrosis severity in primary sclerosing cholangitis}},
  journal = {Hepatology (Baltimore, Md.)},
  year    = {2024},
  doi     = {10.1097/hep.0000000000000557},
  pmid    = {37535809},
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}

@article{chen2023-37573807,
  author  = {Chen, L. and Zhen, Y. and Wang, X. and Wang, J. and Zhu, G.},
  title   = {{Neurovascular glial unit: A target of phytotherapy for cognitive impairments}},
  journal = {Phytomedicine : international journal of phytotherapy and phytopharmacology},
  year    = {2023},
  doi     = {10.1016/j.phymed.2023.155009},
  pmid    = {37573807},
  url     = {https://doi.org/10.1016/j.phymed.2023.155009}
}

@article{im2023-37494443,
  author  = {Im, E. and Jiang, Y. and Stavrides, P. H. and Darji, S. and Erdjument-Bromage, H. and Neubert, T. A. and Choi, J. Y. and Wegiel, J. and others},
  title   = {{Lysosomal dysfunction in Down syndrome and Alzheimer mouse models is caused by v-ATPase inhibition by Tyr682-phosphorylated APP βCTF}},
  journal = {Science advances},
  year    = {2023},
  doi     = {10.1126/sciadv.adg1925},
  pmid    = {37494443},
  url     = {https://doi.org/10.1126/sciadv.adg1925}
}

@article{tan2023-36889359,
  author  = {Tan, J. and Fan, W. and Liu, T. and Zhu, B. and Liu, Y. and Wang, S. and Wu, J. and Liu, J. and others},
  title   = {{TREM2+ macrophages suppress CD8+ T-cell infiltration after transarterial chemoembolisation in hepatocellular carcinoma}},
  journal = {Journal of hepatology},
  year    = {2023},
  doi     = {10.1016/j.jhep.2023.02.032},
  pmid    = {36889359},
  url     = {https://doi.org/10.1016/j.jhep.2023.02.032}
}

@article{zhou2023-36658241,
  author  = {Zhou, Y. and Tada, M. and Cai, Z. and Andhey, P. S. and Swain, A. and Miller, K. R. and Gilfillan, S. and Artyomov, M. N. and others},
  title   = {{Human early-onset dementia caused by DAP12 deficiency reveals a unique signature of dysregulated microglia}},
  journal = {Nature immunology},
  year    = {2023},
  doi     = {10.1038/s41590-022-01403-y},
  pmid    = {36658241},
  url     = {https://doi.org/10.1038/s41590-022-01403-y}
}

@article{roshan2023-36776051,
  author  = {Roshan, S. A. and Elangovan, G. and Gunaseelan, D. and Jayachandran, S. K. and Kandasamy, M. and Anusuyadevi, M.},
  title   = {{Pathogenomic Signature and Aberrant Neurogenic Events in Experimental Cerebral Ischemic Stroke: A Neurotranscriptomic-Based Implication for Dementia}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2023},
  doi     = {10.3233/jad-220831},
  pmid    = {36776051},
  url     = {https://doi.org/10.3233/jad-220831}
}

@article{rother2022-36443293,
  author  = {Rother, C. and Uhlmann, R. E. and Müller, S. A. and Schelle, J. and Skodras, A. and Obermüller, U. and Häsler, L. M. and Lambert, M. and others},
  title   = {{Experimental evidence for temporal uncoupling of brain Aβ deposition and neurodegenerative sequelae}},
  journal = {Nature communications},
  year    = {2022},
  doi     = {10.1038/s41467-022-34538-5},
  pmid    = {36443293},
  url     = {https://doi.org/10.1038/s41467-022-34538-5}
}

@article{saloner2022-36041868,
  author  = {Saloner, R. and Fonseca, C. and Paolillo, E. W. and Asken, B. M. and Djukic, N. A. and Lee, S. and Nilsson, J. and Brinkmalm, A. and others},
  title   = {{Combined Effects of Synaptic and Axonal Integrity on Longitudinal Gray Matter Atrophy in Cognitively Unimpaired Adults}},
  journal = {Neurology},
  year    = {2022},
  doi     = {10.1212/wnl.0000000000201165},
  pmid    = {36041868},
  url     = {https://doi.org/10.1212/wnl.0000000000201165}
}

@article{hauremirande2022-36002854,
  author  = {Haure-Mirande, J. V. and Audrain, M. and Ehrlich, M. E. and Gandy, S.},
  title   = {{Microglial TYROBP/DAP12 in Alzheimer's disease: Transduction of physiological and pathological signals across TREM2}},
  journal = {Molecular neurodegeneration},
  year    = {2022},
  doi     = {10.1186/s13024-022-00552-w},
  pmid    = {36002854},
  url     = {https://doi.org/10.1186/s13024-022-00552-w}
}

@article{meeker2022-35167933,
  author  = {Meeker, K. L. and Butt, O. H. and Gordon, B. A. and Fagan, A. M. and Schindler, S. E. and Morris, J. C. and Benzinger, T. L. S. and Ances, B. M.},
  title   = {{Cerebrospinal fluid neurofilament light chain is a marker of aging and white matter damage}},
  journal = {Neurobiology of disease},
  year    = {2022},
  doi     = {10.1016/j.nbd.2022.105662},
  pmid    = {35167933},
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}

@article{belsare2022-35082148,
  author  = {Belsare, K. D. and Wu, H. and Mondal, D. and Bond, A. and Castillo, E. and Jin, J. and Jo, H. and Roush, A. E. and others},
  title   = {{Soluble TREM2 inhibits secondary nucleation of Aβ fibrillization and enhances cellular uptake of fibrillar Aβ}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2022},
  doi     = {10.1073/pnas.2114486119},
  pmid    = {35082148},
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}

@article{perluigi2022-34812584,
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  title   = {{Aberrant crosstalk between insulin signaling and mTOR in young Down syndrome individuals revealed by neuronal-derived extracellular vesicles}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2022},
  doi     = {10.1002/alz.12499},
  pmid    = {34812584},
  url     = {https://doi.org/10.1002/alz.12499}
}

@article{kotredes2021-34707490,
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  title   = {{Uncovering Disease Mechanisms in a Novel Mouse Model Expressing Humanized APOEε4 and Trem2*R47H}},
  journal = {Frontiers in aging neuroscience},
  year    = {2021},
  doi     = {10.3389/fnagi.2021.735524},
  pmid    = {34707490},
  url     = {https://doi.org/10.3389/fnagi.2021.735524}
}

@article{qiu2021-34526055,
  author  = {Qiu, S. and Palavicini, J. P. and Wang, J. and Gonzalez, N. S. and He, S. and Dustin, E. and Zou, C. and Ding, L. and others},
  title   = {{Adult-onset CNS myelin sulfatide deficiency is sufficient to cause Alzheimer's disease-like neuroinflammation and cognitive impairment}},
  journal = {Molecular neurodegeneration},
  year    = {2021},
  doi     = {10.1186/s13024-021-00488-7},
  pmid    = {34526055},
  url     = {https://doi.org/10.1186/s13024-021-00488-7}
}

@article{kaliszewska2022-34491551,
  author  = {Kaliszewska, A. and Allison, J. and Col, T. T. and Shaw, C. and Arias, N.},
  title   = {{Elucidating the Role of Cerebellar Synaptic Dysfunction in C9orf72-ALS/FTD - a Systematic Review and Meta-Analysis}},
  journal = {Cerebellum (London, England)},
  year    = {2022},
  doi     = {10.1007/s12311-021-01320-0},
  pmid    = {34491551},
  url     = {https://doi.org/10.1007/s12311-021-01320-0}
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@article{claes2021-34301296,
  author  = {Claes, C. and Danhash, E. P. and Hasselmann, J. and Chadarevian, J. P. and Shabestari, S. K. and England, W. E. and Lim, T. E. and Hidalgo, J. L. S. and others},
  title   = {{Plaque-associated human microglia accumulate lipid droplets in a chimeric model of Alzheimer's disease}},
  journal = {Molecular neurodegeneration},
  year    = {2021},
  doi     = {10.1186/s13024-021-00473-0},
  pmid    = {34301296},
  url     = {https://doi.org/10.1186/s13024-021-00473-0}
}

@article{park2021-33902708,
  author  = {Park, J. S. and Kam, T. I. and Lee, S. and Park, H. and Oh, Y. and Kwon, S. H. and Song, J. J. and Kim, D. and others},
  title   = {{Blocking microglial activation of reactive astrocytes is neuroprotective in models of Alzheimer's disease}},
  journal = {Acta neuropathologica communications},
  year    = {2021},
  doi     = {10.1186/s40478-021-01180-z},
  pmid    = {33902708},
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@article{andersen2021-33899255,
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  title   = {{Reduced Synaptic Density in Patients with Lewy Body Dementia: An [11 C]UCB-J PET Imaging Study}},
  journal = {Movement disorders : official journal of the Movement Disorder Society},
  year    = {2021},
  doi     = {10.1002/mds.28617},
  pmid    = {33899255},
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@article{lananna2020-33328329,
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  title   = {{Chi3l1/YKL-40 is controlled by the astrocyte circadian clock and regulates neuroinflammation and Alzheimer's disease pathogenesis}},
  journal = {Science translational medicine},
  year    = {2020},
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  pmid    = {33328329},
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@article{zhao2020-32887883,
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  title   = {{Pharmacologically reversible zonation-dependent endothelial cell transcriptomic changes with neurodegenerative disease associations in the aged brain}},
  journal = {Nature communications},
  year    = {2020},
  doi     = {10.1038/s41467-020-18249-3},
  pmid    = {32887883},
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@article{dsouza2020-32986108,
  author  = {D'Souza, H. and Mason, L. and Mok, K. Y. and Startin, C. M. and Hamburg, S. and Hithersay, R. and Baksh, R. A. and Hardy, J. and others},
  title   = {{Differential Associations of Apolipoprotein E ε4 Genotype With Attentional Abilities Across the Life Span of Individuals With Down Syndrome}},
  journal = {JAMA network open},
  year    = {2020},
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  pmid    = {32986108},
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  title   = {{The role of liquid-liquid phase separation in aggregation of the TDP-43 low-complexity domain}},
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  title   = {{Effect of a PROtein-enriched MEDiterranean diet and EXercise (PROMED-EX) on nutritional status and cognitive performance in older adults at risk of undernutrition and cognitive decline: the PROMED-EX randomized controlled trial}},
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  title   = {{Arc mediates intercellular tau transmission via extracellular vesicles}},
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  title   = {{Impact of Postlabeling Delay on Arterial Spin-Labeling MRI-Based Measures of Cerebral Blood Flow in a Simultaneous PET/MRI Study of Aging}},
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@article{alwesabi2026-41996958,
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  title   = {{Toward precision risk stratification of postoperative cognitive dysfunction: Preoperative inflammatory and neurodegenerative protein biomarkers in orthopedic surgery: A systematic review}},
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@article{mastrangelo2026-41792827,
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  title   = {{Prevalence and clinical effects of Lewy Body pathology in non-prion rapidly progressive dementias: a retrospective cohort study}},
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@article{brossaud2026-41786890,
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  title   = {{The short-chain fatty acid butyrate prevents gut-brain amyloid-β pathology and neuroinflammation in an Alzheimer mouse model}},
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@article{hall2026-41650358,
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  title   = {{Association of Cortical Free Water With Brain Tau Tangle Load in the Alzheimer Disease Continuum}},
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  year    = {2026},
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@article{goldstein2026-41517809,
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  title   = {{Preclinical Catecholaminergic Biomarkers of Central Lewy Body Diseases}},
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  year    = {2026},
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@article{tanner2025-2217c07a,
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  title   = {{Plasma Biomarker Association with Cognition in Uganda}},
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  year    = {2025},
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@article{moqadam2025-41519606,
  author  = {Moqadam, Roqaie and Azizi, Houman and Zeighami, Yashar and Dadar, Mahsa},
  title   = {{Gray and white matter pathology progression in Parkinson's disease patients that develop mild cognitive impairment}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
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@article{zarkali2025-41290734,
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  title   = {{Evidence for divergent cortical organisation in Parkinson’s disease and Lewy Body Dementia}},
  journal = {Nature Communications},
  year    = {2025},
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@article{vokali2025-41136425,
  author  = {Vokali, Efthymia and Chevalier, Elodie and Dreyfus, Nicolas and Charmey, Dorian and Melly, Tania and Kocher, Jacqueline and Ratnam, Monisha and Serra, Andreia M. and others},
  title   = {{Development of [18F]ACI-19626 as a first-in-class brain PET tracer for imaging TDP-43 pathology}},
  journal = {Nature Communications},
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@article{boyanova2025-40856010,
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  title   = {{Multi-modal comparative phenotyping of knock-in mouse models of frontotemporal dementia/amyotrophic lateral sclerosis}},
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@article{noh2025-40640892,
  author  = {Noh, Min‐Young and Kwon, Hyuk Sung and Kwon, Min‐Soo and Nahm, Minyeop and Jin, Hee Kyung and Bae, Jae‐sung and Kim, Seung Hyun},
  title   = {{Biomarkers and therapeutic strategies targeting microglia in neurodegenerative diseases: current status and future directions}},
  journal = {Molecular Neurodegeneration},
  year    = {2025},
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@article{liu2025-40605462,
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  title   = {{Accuracy of blood-based neurofilament light to different genetic frontotemporal dementia from primary psychiatric disorders}},
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  year    = {2025},
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@article{giudici2025-40601428,
  author  = {Giudici, K. V. and de Souto Barreto, P. and Cantet, C. and Zetterberg, H. and Blennow, K. and Vellas, B. and {MAPT/DSA group}},
  title   = {{Associations between intrinsic capacity, plasma p-tau181 and cognitive function over a 5-year follow-up among community-dwelling older adults: a secondary analysis of the MAPT Study}},
  journal = {The Journal of frailty \& aging},
  year    = {2025},
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  pmid    = {40601428},
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@article{nordestgaard2025-40504878,
  author  = {Nordestgaard, Ask Tybjærg and Nordestgaard, Børge Grønne},
  title   = {{Remnant cholesterol lowering in cardiovascular disease risk reduction in statin, ezetimibe, and PCSK9 inhibitor trials: meta-regression analyses}},
  journal = {European Journal of Preventive Cardiology},
  year    = {2025},
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@article{perrone2025-40289944,
  author  = {Perrone, Pasquale and D’Angelo, Stefania},
  title   = {{Gut Microbiota Modulation Through Mediterranean Diet Foods: Implications for Human Health}},
  journal = {Nutrients},
  year    = {2025},
  doi     = {10.3390/nu17060948},
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@article{gonzalez2025-39994784,
  author  = {González, Alba Cervantes and Goossens, Julie and Campuzano, E. Vera and Sala, Isabel and Sánchez‐Saudinós, María Belén and Rodríguez‐Baz, Íñigo and Lidón, Laia and Perlaza, Danna and others},
  title   = {{Evaluation of cerebrospinal fluid levels of VAMP-2 and SNAP-25 in a dementia with Lewy bodies clinical cohort stratified by Alzheimer’s pathophysiological biomarkers}},
  journal = {Alzheimer s Research \& Therapy},
  year    = {2025},
  doi     = {10.1186/s13195-025-01685-y},
  pmid    = {39994784},
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@article{hawley2025-39978410,
  author  = {Hawley, John A. and Forster, Samuel C. and Giles, Edward M.},
  title   = {{Exercise, the Gut Microbiome and Gastrointestinal Diseases: Therapeutic Impact and Molecular Mechanisms}},
  journal = {Gastroenterology},
  year    = {2025},
  doi     = {10.1053/j.gastro.2025.01.224},
  pmid    = {39978410},
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@article{delima2025-39997749,
  author  = {de Lima, Enzo Pereira and Laurindo, Lucas Fornari and Catharin, Vitor Cavallari Strozze and Direito, Rosa and Tanaka, Masaru and German, Íris Jasmin Santos and Lamas, Caroline Barbalho and Guiguer, Élen Landgraf and others},
  title   = {{Polyphenols, Alkaloids, and Terpenoids Against Neurodegeneration: Evaluating the Neuroprotective Effects of Phytocompounds Through a Comprehensive Review of the Current Evidence}},
  journal = {Metabolites},
  year    = {2025},
  doi     = {10.3390/metabo15020124},
  pmid    = {39997749},
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@article{wolner2025-39912369,
  author  = {Wolner, Sofia Hjorth and Gleerup, Helena Sophia and Musaeus, Christian Sandøe and Høgh, Peter and Ashton, Nicholas J. and Brinkmalm, Ann and Nilsson, Johanna E. and Grötschel, Lana and others},
  title   = {{Synaptosomal‐Associated Protein 25 kDA (SNAP‐25) Levels in Cerebrospinal Fluid: Implications for Alzheimer's Disease Diagnosis and Monitoring}},
  journal = {Synapse},
  year    = {2025},
  doi     = {10.1002/syn.70010},
  pmid    = {39912369},
  url     = {https://doi.org/10.1002/syn.70010}
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@article{jung2025-39916501,
  author  = {Jung, Inha and Park, So Young and Lee, Da Young and Cho, Hyun Joo and Lee, Seung Ku and Seo, Ji A and Kim, Nan Hee and Shin, Chol and others},
  title   = {{Association of metabolic dysfunction‐associated fatty liver disease with white matter hyperintensity and cognitive decline: A longitudinal cohort study}},
  journal = {Diabetes Obesity and Metabolism},
  year    = {2025},
  doi     = {10.1111/dom.16232},
  pmid    = {39916501},
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@article{scaglione2025-39861488,
  author  = {Scaglione, Stefania and Di Chiara, Tiziana and Daidone, Mario and Tuttolomondo, Antonino},
  title   = {{Effects of the Mediterranean Diet on the Components of Metabolic Syndrome Concerning the Cardiometabolic Risk}},
  journal = {Nutrients},
  year    = {2025},
  doi     = {10.3390/nu17020358},
  pmid    = {39861488},
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@article{ryczek2025-39789939,
  author  = {Ryczek, Cameron A. and Rivas, Rhiannon and Hemphill, Lea and Zanotelli, Zackary and Renteria, Nicholas and Dashtipour, Khashayar and Jones, Jacob D.},
  title   = {{Association of Favorable Cerebrospinal Fluid Markers With Reversion of Mild Cognitive Impairment Due to Parkinson’s Disease}},
  journal = {Journal of Neuropsychiatry},
  year    = {2025},
  doi     = {10.1176/appi.neuropsych.20240099},
  pmid    = {39789939},
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@article{wezel2025-41426431,
  author  = {Wezel, Denise and Parent, Olivier and Costantino, Manuela and Sifi, Lina and Pigeau, Grace and Gervais, Nicole J and McQuarrie, Ann and Maranzano, Josefina and others},
  title   = {{Investigating links between white matter hyperintensities and menopausal status using robust age-correction methods in UK Biobank}},
  journal = {Brain Communications},
  year    = {2025},
  doi     = {10.1093/braincomms/fcaf475},
  pmid    = {41426431},
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  title   = {{TREM2 promotes macrophage polarization from M1 to M2 and suppresses osteoarthritis through the NF-κB/CXCL3 axis}},
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  title   = {{TREM2 regulates microglial lipid droplet formation and represses post-ischemic brain injury}},
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@article{kent2024-37452201,
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  title   = {{Transcriptomic atlas and interaction networks of brain cells in mouse CNS demyelination and remyelination}},
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@article{stern2023-cdf6b8dd,
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  title   = {{Plasma NT1-tau and Aβ42correlate with age and cognitive function in two large Down syndrome cohorts}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2023},
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@article{liebold2023-36766683,
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  title   = {{TREM2 Regulates the Removal of Apoptotic Cells and Inflammatory Processes during the Progression of NAFLD}},
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  year    = {2023},
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@article{wang2022-36031601,
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  title   = {{Emerging strategies in targeting tumor-resident myeloid cells for cancer immunotherapy}},
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  title   = {{Single-cell RNA-Seq reveals changes in immune landscape in post-traumatic osteoarthritis}},
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  title   = {{Galectin-3, a rising star in modulating microglia activation under conditions of neurodegeneration}},
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@article{jairaman2022-35191835,
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  title   = {{TREM2 regulates purinergic receptor-mediated calcium signaling and motility in human iPSC-derived microglia}},
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  title   = {{A Perspective on Nrf2 Signaling Pathway for Neuroinflammation: A Potential Therapeutic Target in Alzheimer's and Parkinson's Diseases}},
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  year    = {2021},
  doi     = {10.3389/fncel.2021.787258},
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@article{eratne2022-35179048,
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  title   = {{Plasma neurofilament light chain protein is not increased in treatment-resistant schizophrenia and first-degree relatives}},
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  year    = {2022},
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@article{gaikwad2021-34289368,
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  title   = {{Tau oligomer induced HMGB1 release contributes to cellular senescence and neuropathology linked to Alzheimer's disease and frontotemporal dementia}},
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@article{bondarev2021-33971031,
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  title   = {{Recent developments of HDAC inhibitors: Emerging indications and novel molecules}},
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  year    = {2021},
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@article{moore2021-34031194,
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  title   = {{Association of Aortic Stiffness With Biomarkers of Neuroinflammation, Synaptic Dysfunction, and Neurodegeneration}},
  journal = {Neurology},
  year    = {2021},
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  pmid    = {34031194},
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@article{tziortzouda2021-33654312,
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  title   = {{Triad of TDP43 control in neurodegeneration: autoregulation, localization and aggregation}},
  journal = {Nature reviews. Neuroscience},
  year    = {2021},
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@article{sharif2021-33627323,
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  title   = {{Beneficial Metabolic Effects of TREM2 in Obesity Are Uncoupled From Its Expression on Macrophages}},
  journal = {Diabetes},
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  title   = {{Frontotemporal lobar degeneration proteinopathies have disparate microscopic patterns of white and grey matter pathology}},
  journal = {Acta neuropathologica communications},
  year    = {2021},
  doi     = {10.1186/s40478-021-01129-2},
  pmid    = {33622418},
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@article{chen2021-33680283,
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  title   = {{Associations among Cognitive Functions, Plasma DNA, and Diffusion Tensor Image along the Perivascular Space (DTI-ALPS) in Patients with Parkinson's Disease}},
  journal = {Oxidative medicine and cellular longevity},
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@article{yanelli2021-33555200,
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  title   = {{Fine Particle Exposure and Clinical Aggravation in Neurodegenerative Diseases in New York State}},
  journal = {Environmental health perspectives},
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@article{portz2021-33446423,
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  title   = {{FUS and TDP-43 Phases in Health and Disease}},
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  year    = {2021},
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@article{pan2021-32894711,
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  title   = {{Multi-View Separable Pyramid Network for AD Prediction at MCI Stage by 18F-FDG Brain PET Imaging}},
  journal = {IEEE transactions on medical imaging},
  year    = {2021},
  doi     = {10.1109/tmi.2020.3022591},
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@article{andreone2020-32514138,
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  title   = {{Alzheimer's-associated PLCγ2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia}},
  journal = {Nature neuroscience},
  year    = {2020},
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  pmid    = {32514138},
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@article{chowdhury2020-32178745,
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  title   = {{Systematic review of gene expression studies in people with Lewy body dementia}},
  journal = {Acta neuropsychiatrica},
  year    = {2020},
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  pmid    = {32178745},
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@article{derossi2020-32160554,
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  title   = {{Neuronal BIN1 Regulates Presynaptic Neurotransmitter Release and Memory Consolidation}},
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  title   = {{A locked immunometabolic switch underlies TREM2 R47H loss of function in human iPSC-derived microglia}},
  journal = {FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year    = {2020},
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@article{zhang2019-31590042,
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  title   = {{Curcumin inhibits LPS-induced neuroinflammation by promoting microglial M2 polarization via TREM2/ TLR4/ NF-κB pathways in BV2 cells}},
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@article{schwartz2019-31461676,
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  title   = {{Autoidentification of perivascular spaces in white matter using clinical field strength T1 and FLAIR MR imaging}},
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@article{duan2019-30728452,
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  title   = {{PARylation regulates stress granule dynamics, phase separation, and neurotoxicity of disease-related RNA-binding proteins}},
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  title   = {{Conditional BDNF Delivery from Astrocytes Rescues Memory Deficits, Spine Density, and Synaptic Properties in the 5xFAD Mouse Model of Alzheimer Disease}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2019},
  doi     = {10.1523/jneurosci.2121-18.2019},
  pmid    = {30700530},
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  title   = {{The complexity of neuroinflammation consequent to traumatic brain injury: from research evidence to potential treatments}},
  journal = {Acta neuropathologica},
  year    = {2019},
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  title   = {{Human Induced Pluripotent Stem Cell-Derived Microglia-Like Cells Harboring TREM2 Missense Mutations Show Specific Deficits in Phagocytosis}},
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  pmid    = {30157425},
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@article{quadri2018-29887161,
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  title   = {{LRP10 genetic variants in familial Parkinson's disease and dementia with Lewy bodies: a genome-wide linkage and sequencing study}},
  journal = {The Lancet. Neurology},
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  pmid    = {29887161},
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  title   = {{Genome-wide association study identifies two loci influencing plasma neurofilament light levels}},
  journal = {BMC medical genomics},
  year    = {2018},
  doi     = {10.1186/s12920-018-0364-8},
  pmid    = {29747637},
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@article{mecca2018-29361745,
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  title   = {{Microglia and Aging: The Role of the TREM2-DAP12 and CX3CL1-CX3CR1 Axes}},
  journal = {International journal of molecular sciences},
  year    = {2018},
  doi     = {10.3390/ijms19010318},
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@article{simone2018-29113975,
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  title   = {{G-quadruplex-binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo}},
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  pmid    = {29113975},
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@article{paulson2018-29325606,
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  title   = {{Repeat expansion diseases}},
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  title   = {{ADAM17 is the main sheddase for the generation of human triggering receptor expressed in myeloid cells (hTREM2) ectodomain and cleaves TREM2 after Histidine 157}},
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  year    = {2017},
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@article{ladenbauer2017-28637840,
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  title   = {{Promoting Sleep Oscillations and Their Functional Coupling by Transcranial Stimulation Enhances Memory Consolidation in Mild Cognitive Impairment}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2017},
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  pmid    = {28637840},
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@article{yeh2017-28442216,
  author  = {Yeh, F. L. and Hansen, D. V. and Sheng, M.},
  title   = {{TREM2, Microglia, and Neurodegenerative Diseases}},
  journal = {Trends in molecular medicine},
  year    = {2017},
  doi     = {10.1016/j.molmed.2017.03.008},
  pmid    = {28442216},
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@article{wang2017-28188218,
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  title   = {{Focal Solute Trapping and Global Glymphatic Pathway Impairment in a Murine Model of Multiple Microinfarcts}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2017},
  doi     = {10.1523/jneurosci.2112-16.2017},
  pmid    = {28188218},
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@article{brendel2017-28197095,
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  title   = {{Increase of TREM2 during Aging of an Alzheimer's Disease Mouse Model Is Paralleled by Microglial Activation and Amyloidosis}},
  journal = {Frontiers in aging neuroscience},
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}

@article{li2009-19456322,
  author  = {Li, H. and Borinskaya, S. and Yoshimura, K. and Kal'ina, N. and Marusin, A. and Stepanov, V. A. and Qin, Z. and Khaliq, S. and others},
  title   = {{Refined geographic distribution of the oriental ALDH2*504Lys (nee 487Lys) variant}},
  journal = {Annals of human genetics},
  year    = {2009},
  doi     = {10.1111/j.1469-1809.2009.00517.x},
  pmid    = {19456322},
  url     = {https://doi.org/10.1111/j.1469-1809.2009.00517.x}
}

@article{xu2009-18266214,
  author  = {Xu, L. and Groth, K. M. and Pearlson, G. and Schretlen, D. J. and Calhoun, V. D.},
  title   = {{Source-based morphometry: the use of independent component analysis to identify gray matter differences with application to schizophrenia}},
  journal = {Human brain mapping},
  year    = {2009},
  doi     = {10.1002/hbm.20540},
  pmid    = {18266214},
  url     = {https://doi.org/10.1002/hbm.20540}
}

@article{ohrfelt2009-19022350,
  author  = {Ohrfelt, A. and Grognet, P. and Andreasen, N. and Wallin, A. and Vanmechelen, E. and Blennow, K. and Zetterberg, H.},
  title   = {{Cerebrospinal fluid alpha-synuclein in neurodegenerative disorders-a marker of synapse loss?}},
  journal = {Neuroscience letters},
  year    = {2009},
  doi     = {10.1016/j.neulet.2008.11.015},
  pmid    = {19022350},
  url     = {https://doi.org/10.1016/j.neulet.2008.11.015}
}

@article{hemming2008-18942891,
  author  = {Hemming, M. L. and Elias, J. E. and Gygi, S. P. and Selkoe, D. J.},
  title   = {{Proteomic profiling of gamma-secretase substrates and mapping of substrate requirements}},
  journal = {PLoS biology},
  year    = {2008},
  doi     = {10.1371/journal.pbio.0060257},
  pmid    = {18942891},
  url     = {https://doi.org/10.1371/journal.pbio.0060257}
}

@article{weihl2008-18796596,
  author  = {Weihl, C. C. and Temiz, P. and Miller, S. E. and Watts, G. and Smith, C. and Forman, M. and Hanson, P. I. and Kimonis, V. and others},
  title   = {{TDP-43 accumulation in inclusion body myopathy muscle suggests a common pathogenic mechanism with frontotemporal dementia}},
  journal = {Journal of neurology, neurosurgery, and psychiatry},
  year    = {2008},
  doi     = {10.1136/jnnp.2007.131334},
  pmid    = {18796596},
  url     = {https://doi.org/10.1136/jnnp.2007.131334}
}

@article{schilling2008-18836460,
  author  = {Schilling, S. and Zeitschel, U. and Hoffmann, T. and Heiser, U. and Francke, M. and Kehlen, A. and Holzer, M. and Hutter-Paier, B. and others},
  title   = {{Glutaminyl cyclase inhibition attenuates pyroglutamate Abeta and Alzheimer's disease-like pathology}},
  journal = {Nature medicine},
  year    = {2008},
  doi     = {10.1038/nm.1872},
  pmid    = {18836460},
  url     = {https://doi.org/10.1038/nm.1872}
}

@article{cataldo2008-18535180,
  author  = {Cataldo, A. M. and Mathews, P. M. and Boiteau, A. B. and Hassinger, L. C. and Peterhoff, C. M. and Jiang, Y. and Mullaney, K. and Neve, R. L. and others},
  title   = {{Down syndrome fibroblast model of Alzheimer-related endosome pathology: accelerated endocytosis promotes late endocytic defects}},
  journal = {The American journal of pathology},
  year    = {2008},
  doi     = {10.2353/ajpath.2008.071053},
  pmid    = {18535180},
  url     = {https://doi.org/10.2353/ajpath.2008.071053}
}

@article{rezaizadeh2008-18457818,
  author  = {Rezai-Zadeh, K. and Arendash, G. W. and Hou, H. and Fernandez, F. and Jensen, M. and Runfeldt, M. and Shytle, R. D. and Tan, J.},
  title   = {{Green tea epigallocatechin-3-gallate (EGCG) reduces beta-amyloid mediated cognitive impairment and modulates tau pathology in Alzheimer transgenic mice}},
  journal = {Brain research},
  year    = {2008},
  doi     = {10.1016/j.brainres.2008.02.107},
  pmid    = {18457818},
  url     = {https://doi.org/10.1016/j.brainres.2008.02.107}
}

@article{winklhofer2008-18216876,
  author  = {Winklhofer, K. F. and Tatzelt, J. and Haass, C.},
  title   = {{The two faces of protein misfolding: gain- and loss-of-function in neurodegenerative diseases}},
  journal = {The EMBO journal},
  year    = {2008},
  doi     = {10.1038/sj.emboj.7601930},
  pmid    = {18216876},
  url     = {https://doi.org/10.1038/sj.emboj.7601930}
}

@article{verwer2007-18055496,
  author  = {Verwer, R. W. and Sluiter, A. A. and Balesar, R. A. and Baayen, J. C. and Noske, D. P. and Dirven, C. M. and Wouda, J. and van Dam, A. M. and others},
  title   = {{Mature astrocytes in the adult human neocortex express the early neuronal marker doublecortin}},
  journal = {Brain : a journal of neurology},
  year    = {2007},
  doi     = {10.1093/brain/awm264},
  pmid    = {18055496},
  url     = {https://doi.org/10.1093/brain/awm264}
}

@article{higashi2007-17963732,
  author  = {Higashi, S. and Iseki, E. and Yamamoto, R. and Minegishi, M. and Hino, H. and Fujisawa, K. and Togo, T. and Katsuse, O. and others},
  title   = {{Concurrence of TDP-43, tau and alpha-synuclein pathology in brains of Alzheimer's disease and dementia with Lewy bodies}},
  journal = {Brain research},
  year    = {2007},
  doi     = {10.1016/j.brainres.2007.09.048},
  pmid    = {17963732},
  url     = {https://doi.org/10.1016/j.brainres.2007.09.048}
}

@article{beyer2007-17709706,
  author  = {Beyer, M. K. and Larsen, J. P. and Aarsland, D.},
  title   = {{Gray matter atrophy in Parkinson disease with dementia and dementia with Lewy bodies}},
  journal = {Neurology},
  year    = {2007},
  doi     = {10.1212/01.wnl.0000269666.62598.1c},
  pmid    = {17709706},
  url     = {https://doi.org/10.1212/01.wnl.0000269666.62598.1c}
}

@article{snowden2007-17569065,
  author  = {Snowden, J. and Neary, D. and Mann, D.},
  title   = {{Frontotemporal lobar degeneration: clinical and pathological relationships}},
  journal = {Acta neuropathologica},
  year    = {2007},
  doi     = {10.1007/s00401-007-0236-3},
  pmid    = {17569065},
  url     = {https://doi.org/10.1007/s00401-007-0236-3}
}

@article{sikk2007-17511846,
  author  = {Sikk, K. and Taba, P. and Haldre, S. and Bergquist, J. and Nyholm, D. and Zjablov, G. and Asser, T. and Aquilonius, S. M.},
  title   = {{Irreversible motor impairment in young addicts--ephedrone, manganism or both?}},
  journal = {Acta neurologica Scandinavica},
  year    = {2007},
  doi     = {10.1111/j.1600-0404.2007.00818.x},
  pmid    = {17511846},
  url     = {https://doi.org/10.1111/j.1600-0404.2007.00818.x}
}

@article{shaftel2007-17549256,
  author  = {Shaftel, S. S. and Kyrkanides, S. and Olschowka, J. A. and Miller, J. N. and Johnson, R. E. and O'Banion, M. K.},
  title   = {{Sustained hippocampal IL-1 beta overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology}},
  journal = {The Journal of clinical investigation},
  year    = {2007},
  doi     = {10.1172/jci31450},
  pmid    = {17549256},
  url     = {https://doi.org/10.1172/jci31450}
}

@article{berger2007-17409229,
  author  = {Berger, Z. and Roder, H. and Hanna, A. and Carlson, A. and Rangachari, V. and Yue, M. and Wszolek, Z. and Ashe, K. and others},
  title   = {{Accumulation of pathological tau species and memory loss in a conditional model of tauopathy}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2007},
  doi     = {10.1523/jneurosci.0587-07.2007},
  pmid    = {17409229},
  url     = {https://doi.org/10.1523/jneurosci.0587-07.2007}
}

@article{neumann2007-17279000,
  author  = {Neumann, M. and Mackenzie, I. R. and Cairns, N. J. and Boyer, P. J. and Markesbery, W. R. and Smith, C. D. and Taylor, J. P. and Kretzschmar, H. A. and others},
  title   = {{TDP-43 in the ubiquitin pathology of frontotemporal dementia with VCP gene mutations}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2007},
  doi     = {10.1097/nen.0b013e31803020b9},
  pmid    = {17279000},
  url     = {https://doi.org/10.1097/nen.0b013e31803020b9}
}

@article{krabbe2007-17151862,
  author  = {Krabbe, K. S. and Nielsen, A. R. and Krogh-Madsen, R. and Plomgaard, P. and Rasmussen, P. and Erikstrup, C. and Fischer, C. P. and Lindegaard, B. and others},
  title   = {{Brain-derived neurotrophic factor (BDNF) and type 2 diabetes}},
  journal = {Diabetologia},
  year    = {2007},
  doi     = {10.1007/s00125-006-0537-4},
  pmid    = {17151862},
  url     = {https://doi.org/10.1007/s00125-006-0537-4}
}

@article{kimura2007-17135279,
  author  = {Kimura, R. and Kamino, K. and Yamamoto, M. and Nuripa, A. and Kida, T. and Kazui, H. and Hashimoto, R. and Tanaka, T. and others},
  title   = {{The DYRK1A gene, encoded in chromosome 21 Down syndrome critical region, bridges between beta-amyloid production and tau phosphorylation in Alzheimer disease}},
  journal = {Human molecular genetics},
  year    = {2007},
  doi     = {10.1093/hmg/ddl437},
  pmid    = {17135279},
  url     = {https://doi.org/10.1093/hmg/ddl437}
}

@article{lee2006-17015225,
  author  = {Lee, V. M. and Trojanowski, J. Q.},
  title   = {{Mechanisms of Parkinson's disease linked to pathological alpha-synuclein: new targets for drug discovery}},
  journal = {Neuron},
  year    = {2006},
  doi     = {10.1016/j.neuron.2006.09.026},
  pmid    = {17015225},
  url     = {https://doi.org/10.1016/j.neuron.2006.09.026}
}

@article{ziegenhorn2007-16879899,
  author  = {Ziegenhorn, A. A. and Schulte-Herbrüggen, O. and Danker-Hopfe, H. and Malbranc, M. and Hartung, H. D. and Anders, D. and Lang, U. E. and Steinhagen-Thiessen, E. and others},
  title   = {{Serum neurotrophins--a study on the time course and influencing factors in a large old age sample}},
  journal = {Neurobiology of aging},
  year    = {2007},
  doi     = {10.1016/j.neurobiolaging.2006.06.011},
  pmid    = {16879899},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2006.06.011}
}

@article{takeuchi2006-16720574,
  author  = {Takeuchi, H. and Jin, S. and Wang, J. and Zhang, G. and Kawanokuchi, J. and Kuno, R. and Sonobe, Y. and Mizuno, T. and others},
  title   = {{Tumor necrosis factor-alpha induces neurotoxicity via glutamate release from hemichannels of activated microglia in an autocrine manner}},
  journal = {The Journal of biological chemistry},
  year    = {2006},
  doi     = {10.1074/jbc.m600504200},
  pmid    = {16720574},
  url     = {https://doi.org/10.1074/jbc.m600504200}
}

@article{galvan2006-16641106,
  author  = {Galvan, V. and Gorostiza, O. F. and Banwait, S. and Ataie, M. and Logvinova, A. V. and Sitaraman, S. and Carlson, E. and Sagi, S. A. and others},
  title   = {{Reversal of Alzheimer's-like pathology and behavior in human APP transgenic mice by mutation of Asp664}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2006},
  doi     = {10.1073/pnas.0509695103},
  pmid    = {16641106},
  url     = {https://doi.org/10.1073/pnas.0509695103}
}

@article{pueschel2006-16621446,
  author  = {Pueschel, S. M.},
  title   = {{The effect of acetyl-L-carnitine administration on persons with Down syndrome}},
  journal = {Research in developmental disabilities},
  year    = {2006},
  doi     = {10.1016/j.ridd.2004.07.009},
  pmid    = {16621446},
  url     = {https://doi.org/10.1016/j.ridd.2004.07.009}
}

@article{persson2006-16606914,
  author  = {Persson, J. and Lind, J. and Larsson, A. and Ingvar, M. and Cruts, M. and Van Broeckhoven, C. and Adolfsson, R. and Nilsson, L. G. and others},
  title   = {{Altered brain white matter integrity in healthy carriers of the APOE epsilon4 allele: a risk for AD?}},
  journal = {Neurology},
  year    = {2006},
  doi     = {10.1212/01.wnl.0000204180.25361.48},
  pmid    = {16606914},
  url     = {https://doi.org/10.1212/01.wnl.0000204180.25361.48}
}

@article{au2006-16476813,
  author  = {Au, R. and Massaro, J. M. and Wolf, P. A. and Young, M. E. and Beiser, A. and Seshadri, S. and D'Agostino, R. B. and DeCarli, C.},
  title   = {{Association of white matter hyperintensity volume with decreased cognitive functioning: the Framingham Heart Study}},
  journal = {Archives of neurology},
  year    = {2006},
  doi     = {10.1001/archneur.63.2.246},
  pmid    = {16476813},
  url     = {https://doi.org/10.1001/archneur.63.2.246}
}

@article{town2005-16259628,
  author  = {Town, T. and Nikolic, V. and Tan, J.},
  title   = {{The microglial "activation" continuum: from innate to adaptive responses}},
  journal = {Journal of neuroinflammation},
  year    = {2005},
  doi     = {10.1186/1742-2094-2-24},
  pmid    = {16259628},
  url     = {https://doi.org/10.1186/1742-2094-2-24}
}

@article{wahrle2005-16207708,
  author  = {Wahrle, S. E. and Jiang, H. and Parsadanian, M. and Hartman, R. E. and Bales, K. R. and Paul, S. M. and Holtzman, D. M.},
  title   = {{Deletion of Abca1 increases Abeta deposition in the PDAPP transgenic mouse model of Alzheimer disease}},
  journal = {The Journal of biological chemistry},
  year    = {2005},
  doi     = {10.1074/jbc.m508780200},
  pmid    = {16207708},
  url     = {https://doi.org/10.1074/jbc.m508780200}
}

@article{lukiw2005-16151530,
  author  = {Lukiw, W. J. and Cui, J. G. and Marcheselli, V. L. and Bodker, M. and Botkjaer, A. and Gotlinger, K. and Serhan, C. N. and Bazan, N. G.},
  title   = {{A role for docosahexaenoic acid-derived neuroprotectin D1 in neural cell survival and Alzheimer disease}},
  journal = {The Journal of clinical investigation},
  year    = {2005},
  doi     = {10.1172/jci25420},
  pmid    = {16151530},
  url     = {https://doi.org/10.1172/jci25420}
}

@article{masliah2005-15953415,
  author  = {Masliah, E. and Rockenstein, E. and Adame, A. and Alford, M. and Crews, L. and Hashimoto, M. and Seubert, P. and Lee, M. and others},
  title   = {{Effects of alpha-synuclein immunization in a mouse model of Parkinson's disease}},
  journal = {Neuron},
  year    = {2005},
  doi     = {10.1016/j.neuron.2005.05.010},
  pmid    = {15953415},
  url     = {https://doi.org/10.1016/j.neuron.2005.05.010}
}

@article{klunemann2005-15883308,
  author  = {Klünemann, H. H. and Ridha, B. H. and Magy, L. and Wherrett, JR. and Hemelsoet, D. M. and Keen, R. W. and De Bleecker, J. L. and Rossor, M. N. and others},
  title   = {{The genetic causes of basal ganglia calcification, dementia, and bone cysts: DAP12 and TREM2}},
  journal = {Neurology},
  year    = {2005},
  doi     = {10.1212/01.wnl.0000160304.00003.ca},
  pmid    = {15883308},
  url     = {https://doi.org/10.1212/01.wnl.0000160304.00003.ca}
}

@article{david2005-15831501,
  author  = {David, D. C. and Hauptmann, S. and Scherping, I. and Schuessel, K. and Keil, U. and Rizzu, P. and Ravid, R. and Dröse, S. and others},
  title   = {{Proteomic and functional analyses reveal a mitochondrial dysfunction in P301L tau transgenic mice}},
  journal = {The Journal of biological chemistry},
  year    = {2005},
  doi     = {10.1074/jbc.m500356200},
  pmid    = {15831501},
  url     = {https://doi.org/10.1074/jbc.m500356200}
}

@article{vonarnim2005-15749709,
  author  = {von Arnim, C. A. and Kinoshita, A. and Peltan, I. D. and Tangredi, M. M. and Herl, L. and Lee, B. M. and Spoelgen, R. and Hshieh, T. T. and others},
  title   = {{The low density lipoprotein receptor-related protein (LRP) is a novel beta-secretase (BACE1) substrate}},
  journal = {The Journal of biological chemistry},
  year    = {2005},
  doi     = {10.1074/jbc.m414248200},
  pmid    = {15749709},
  url     = {https://doi.org/10.1074/jbc.m414248200}
}

@article{brendza2005-15668737,
  author  = {Brendza, R. P. and Bacskai, B. J. and Cirrito, JR. and Simmons, K. A. and Skoch, J. M. and Klunk, W. E. and Mathis, C. A. and Bales, K. R. and others},
  title   = {{Anti-Abeta antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic mice}},
  journal = {The Journal of clinical investigation},
  year    = {2005},
  doi     = {10.1172/jci23269},
  pmid    = {15668737},
  url     = {https://doi.org/10.1172/jci23269}
}

@article{gonzalezscarano2005-15630430,
  author  = {González-Scarano, F. and Martín-García, J.},
  title   = {{The neuropathogenesis of AIDS}},
  journal = {Nature reviews. Immunology},
  year    = {2005},
  doi     = {10.1038/nri1527},
  pmid    = {15630430},
  url     = {https://doi.org/10.1038/nri1527}
}

@article{taniguchi2005-15611092,
  author  = {Taniguchi, S. and Suzuki, N. and Masuda, M. and Hisanaga, S. and Iwatsubo, T. and Goedert, M. and Hasegawa, M.},
  title   = {{Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols, and porphyrins}},
  journal = {The Journal of biological chemistry},
  year    = {2005},
  doi     = {10.1074/jbc.m408714200},
  pmid    = {15611092},
  url     = {https://doi.org/10.1074/jbc.m408714200}
}

@article{fellgiebel2004-15087585,
  author  = {Fellgiebel, A. and Wille, P. and Müller, M. J. and Winterer, G. and Scheurich, A. and Vucurevic, G. and Schmidt, L. G. and Stoeter, P.},
  title   = {{Ultrastructural hippocampal and white matter alterations in mild cognitive impairment: a diffusion tensor imaging study}},
  journal = {Dementia and geriatric cognitive disorders},
  year    = {2004},
  doi     = {10.1159/000077817},
  pmid    = {15087585},
  url     = {https://doi.org/10.1159/000077817}
}

@article{nestor2003-12902311,
  author  = {Nestor, P. J. and Graham, N. L. and Fryer, T. D. and Williams, G. B. and Patterson, K. and Hodges, JR.},
  title   = {{Progressive non-fluent aphasia is associated with hypometabolism centred on the left anterior insula}},
  journal = {Brain : a journal of neurology},
  year    = {2003},
  doi     = {10.1093/brain/awg240},
  pmid    = {12902311},
  url     = {https://doi.org/10.1093/brain/awg240}
}

@article{lee2003-12655043,
  author  = {Lee, J. and Ryu, H. and Ferrante, R. J. and Morris, S. M. and Ratan, R. R.},
  title   = {{Translational control of inducible nitric oxide synthase expression by arginine can explain the arginine paradox}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2003},
  doi     = {10.1073/pnas.0735876100},
  pmid    = {12655043},
  url     = {https://doi.org/10.1073/pnas.0735876100}
}

@article{wilson2002-12473019,
  author  = {Wilson, C. J. and Finch, C. E. and Cohen, H. J.},
  title   = {{Cytokines and cognition--the case for a head-to-toe inflammatory paradigm}},
  journal = {Journal of the American Geriatrics Society},
  year    = {2002},
  doi     = {10.1046/j.1532-5415.2002.50619.x},
  pmid    = {12473019},
  url     = {https://doi.org/10.1046/j.1532-5415.2002.50619.x}
}

@article{klunk2002-12230326,
  author  = {Klunk, W. E. and Bacskai, B. J. and Mathis, C. A. and Kajdasz, S. T. and McLellan, M. E. and Frosch, M. P. and Debnath, M. L. and Holt, D. P. and others},
  title   = {{Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2002},
  doi     = {10.1093/jnen/61.9.797},
  pmid    = {12230326},
  url     = {https://doi.org/10.1093/jnen/61.9.797}
}

@article{deltredici2002-12030260,
  author  = {Del Tredici, K. and Rüb, U. and De Vos, R. A. and Bohl, JR. and Braak, H.},
  title   = {{Where does parkinson disease pathology begin in the brain?}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2002},
  doi     = {10.1093/jnen/61.5.413},
  pmid    = {12030260},
  url     = {https://doi.org/10.1093/jnen/61.5.413}
}

@article{liu2002-12076984,
  author  = {Liu, B. and Gao, H. M. and Wang, J. Y. and Jeohn, G. H. and Cooper, C. L. and Hong, J. S.},
  title   = {{Role of nitric oxide in inflammation-mediated neurodegeneration}},
  journal = {Annals of the New York Academy of Sciences},
  year    = {2002},
  doi     = {10.1111/j.1749-6632.2002.tb04077.x},
  pmid    = {12076984},
  url     = {https://doi.org/10.1111/j.1749-6632.2002.tb04077.x}
}

@article{uryu2002-11784789,
  author  = {Uryu, K. and Laurer, H. and McIntosh, T. and Praticò, D. and Martinez, D. and Leight, S. and Lee, V. M. and Trojanowski, J. Q.},
  title   = {{Repetitive mild brain trauma accelerates Abeta deposition, lipid peroxidation, and cognitive impairment in a transgenic mouse model of Alzheimer amyloidosis}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2002},
  doi     = {10.1523/jneurosci.22-02-00446.2002},
  pmid    = {11784789},
  url     = {https://doi.org/10.1523/jneurosci.22-02-00446.2002}
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  title   = {{Lecanemab in DIAD: 6‐Month Amyloid PET Results from the DIAN‐TU‐001 Trial}},
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  title   = {{ApoE Genotyping and 12‐Month Longitudinal Tracking of p ‐Tau217 Using Fingerstick Collection in a Population‐Based Cohort}},
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@article{day2025-41513292,
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  title   = {{Tau PET imaging in Black and Latino participants with and without cognitive impairment}},
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  title   = {{Tongxinluo capsule in the treatment of cerebral small vessel disease: protocol of a randomised, double-blind, placebo-controlled, multicentre clinical study (TOPS-CSVD)}},
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  title   = {{Detecting amyloid and tau pathology in Parkinson’s disease, 4R-tauopathies and control subjects with plasma pTau217}},
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@article{zhang2025-40715455,
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  title   = {{Single-cell polygenic risk scores dissect cellular and molecular heterogeneity of complex human diseases}},
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@article{liu2025-40712453,
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@article{su2025-40595567,
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  title   = {{Connexin43 hemichannel blockade turns microglia neuroprotective and mitigates cognitive deficits in a mouse model of amyloidosis}},
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@article{xiao2025-40581647,
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  title   = {{Exercise-induced irisin ameliorates cognitive impairment following chronic cerebral hypoperfusion by suppressing neuroinflammation and hippocampal neuronal apoptosis}},
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@article{wu2025-40260707,
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  title   = {{WMH ‐ DualTasker : A Weakly Supervised Deep Learning Model for Automated White Matter Hyperintensities Segmentation and Visual Rating Prediction}},
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  title   = {{UNC13A Polymorphism Influences Survival in Patients with Frontotemporal Dementia}},
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@article{lapid2025-40170189,
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  title   = {{A pilot randomized controlled double-blind trial of intermittent theta burst stimulation (iTBS) repetitive transcranial magnetic stimulation (rTMS) to improve memory in mild cognitive impairment (MCI): a study protocol}},
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  year    = {2025},
  doi     = {10.1186/s40814-025-01625-5},
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@article{suk2025-40149017,
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  title   = {{A stress-dependent TDP-43 SUMOylation program preserves neuronal function}},
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  year    = {2025},
  doi     = {10.1186/s13024-025-00826-z},
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@article{askelandgjerde2025-40330223,
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  title   = {{Mediation Analyses Link Cardiometabolic Factors and Liver Fat With White Matter Hyperintensities and Cognitive Performance: A UK Biobank Study}},
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  year    = {2025},
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@article{woo2025-39985502,
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  title   = {{Cholinergic degeneration and early cognitive signs in prodromal Lewy body dementia}},
  journal = {Alzheimer s \& Dementia},
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@article{cairns2025-39772530,
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  title   = {{Repetitive injury induces phenotypes associated with Alzheimer’s disease by reactivating HSV-1 in a human brain tissue model}},
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  year    = {2025},
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@article{bayram2025-39886324,
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  title   = {{Sex differences for regional pathology in people with a high likelihood of Lewy body dementia phenotype based on underlying pathology}},
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  year    = {2025},
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@article{jerele2025-40391186,
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  title   = {{Cerebrovascular co-pathology and cholinergic white matter pathways along the Lewy body continuum}},
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@article{rosas2024-39583646,
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  title   = {{Association of plasma neurofilament light chain with microstructural white matter changes in Down syndrome}},
  journal = {Alzheimer's \& dementia (Amsterdam, Netherlands)},
  year    = {2024},
  doi     = {10.1002/dad2.70023},
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@article{zhong2024-38788719,
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  title   = {{Distinct roles of TREM2 in central nervous system cancers and peripheral cancers}},
  journal = {Cancer cell},
  year    = {2024},
  doi     = {10.1016/j.ccell.2024.05.001},
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@article{diluccia2024-38758808,
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  title   = {{TREM2 deficiency reprograms intestinal macrophages and microbiota to enhance anti-PD-1 tumor immunotherapy}},
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  year    = {2024},
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@article{rakina2024-38571605,
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@article{alvarado2024-38181731,
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  title   = {{omicSynth: An open multi-omic community resource for identifying druggable targets across neurodegenerative diseases}},
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@article{gonzales2023-37813589,
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  title   = {{Demographic and Clinical Characteristics Associated With Serum GFAP Levels in an Ethnically Diverse Cohort}},
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@article{chen2023-37563723,
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  title   = {{Target delivery of a PD-1-TREM2 scFv by CAR-T cells enhances anti-tumor efficacy in colorectal cancer}},
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  title   = {{The bidirectional lung brain-axis of amyloid-β pathology: ozone dysregulates the peri-plaque microenvironment}},
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  year    = {2023},
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@article{zhang2023-36635449,
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  title   = {{TREM2hi resident macrophages protect the septic heart by maintaining cardiomyocyte homeostasis}},
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  title   = {{TREM2 activation alleviates neural damage via Akt/CREB/BDNF signalling after traumatic brain injury in mice}},
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  title   = {{Plasma p-tau181/Aβ1-42 ratio predicts Aβ-PET status and correlates with CSF-p-tau181/Aβ1-42 and future cognitive decline}},
  journal = {Alzheimer's \& dementia (Amsterdam, Netherlands)},
  year    = {2022},
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@article{zhu2022-36056435,
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  title   = {{Trem2 deletion enhances tau dispersion and pathology through microglia exosomes}},
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@article{blomeke2022-35655068,
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  title   = {{Quantitative detection of α-Synuclein and Tau oligomers and other aggregates by digital single particle counting}},
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@article{endoumeda2022-35477277,
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  title   = {{Myeloid LXR (Liver X Receptor) Deficiency Induces Inflammatory Gene Expression in Foamy Macrophages and Accelerates Atherosclerosis}},
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  year    = {2022},
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@article{bao2022-35347329,
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  title   = {{Integrative spatial analysis of cell morphologies and transcriptional states with MUSE}},
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@article{zhou2022-35359989,
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  title   = {{Integrated Analysis Highlights the Immunosuppressive Role of TREM2+ Macrophages in Hepatocellular Carcinoma}},
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  year    = {2022},
  doi     = {10.3389/fimmu.2022.848367},
  pmid    = {35359989},
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@article{kim2022-35260170,
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  title   = {{Novel diagnostic tools for identifying cognitive impairment using olfactory-stimulated functional near-infrared spectroscopy: patient-level, single-group, diagnostic trial}},
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  doi     = {10.1186/s13195-022-00978-w},
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@article{walker2022-35164877,
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  title   = {{Differential protein expression in the hippocampi of resilient individuals identified by digital spatial profiling}},
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  title   = {{First-in-Humans Evaluation of 18F-SMBT-1, a Novel 18F-Labeled Monoamine Oxidase-B PET Tracer for Imaging Reactive Astrogliosis}},
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@article{lu2022-34908159,
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  title   = {{Associations of plasma neurofilament light chain and progranulin with frailty in older adults}},
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@article{cohn2021-34925024,
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  title   = {{Multi-Omics Analysis of Microglial Extracellular Vesicles From Human Alzheimer's Disease Brain Tissue Reveals Disease-Associated Signatures}},
  journal = {Frontiers in pharmacology},
  year    = {2021},
  doi     = {10.3389/fphar.2021.766082},
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@article{henn2021-34851663,
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  title   = {{Xenogeneic skin transplantation promotes angiogenesis and tissue regeneration through activated Trem2+ macrophages}},
  journal = {Science advances},
  year    = {2021},
  doi     = {10.1126/sciadv.abi4528},
  pmid    = {34851663},
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@article{bown2022-34810243,
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  title   = {{Physiology and Clinical Relevance of Enlarged Perivascular Spaces in the Aging Brain}},
  journal = {Neurology},
  year    = {2022},
  doi     = {10.1212/wnl.0000000000013077},
  pmid    = {34810243},
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@article{deneubourg2022-34130600,
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  title   = {{The spectrum of neurodevelopmental, neuromuscular and neurodegenerative disorders due to defective autophagy}},
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  title   = {{Cholesterol alters mitophagy by impairing optineurin recruitment and lysosomal clearance in Alzheimer's disease}},
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  title   = {{Crocetin promotes clearance of amyloid-β by inducing autophagy via the STK11/LKB1-mediated AMPK pathway}},
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  title   = {{Dystrophic microglia are associated with neurodegenerative disease and not healthy aging in the human brain}},
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  title   = {{Acute targeting of pre-amyloid seeds in transgenic mice reduces Alzheimer-like pathology later in life}},
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  title   = {{Human brain connectivity: Clinical applications for clinical neurophysiology}},
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  title   = {{Elevated methylation levels, reduced expression levels, and frequent contractions in a clinical cohort of C9orf72 expansion carriers}},
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  title   = {{GWAS Identifies 44 Independent Associated Genomic Loci for Self-Reported Adult Hearing Difficulty in UK Biobank}},
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  title   = {{The BDNFVal66Met SNP modulates the association between beta-amyloid and hippocampal disconnection in Alzheimer's disease}},
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@article{tsai2019-30704514,
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  title   = {{18F-flortaucipir (AV-1451) tau PET in frontotemporal dementia syndromes}},
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  pmid    = {30704514},
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@article{pulliam2019-30610738,
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  title   = {{Plasma neuronal exosomes serve as biomarkers of cognitive impairment in HIV infection and Alzheimer's disease}},
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@article{linnartzgerlach2019-30548312,
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  title   = {{TREM2 triggers microglial density and age-related neuronal loss}},
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@article{suarezcalvet2018-30482868,
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  title   = {{CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline}},
  journal = {EMBO molecular medicine},
  year    = {2018},
  doi     = {10.15252/emmm.201809712},
  pmid    = {30482868},
  url     = {https://doi.org/10.15252/emmm.201809712}
}

@article{hauremirande2019-30283032,
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  title   = {{Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in cerebral Aβ amyloidosis mouse normalizes clinical phenotype and complement subnetwork molecular pathology without reducing Aβ burden}},
  journal = {Molecular psychiatry},
  year    = {2019},
  doi     = {10.1038/s41380-018-0255-6},
  pmid    = {30283032},
  url     = {https://doi.org/10.1038/s41380-018-0255-6}
}

@article{audrain2019-30283031,
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  title   = {{Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in a tauopathy mouse model reduces C1q and normalizes clinical phenotype while increasing spread and state of phosphorylation of tau}},
  journal = {Molecular psychiatry},
  year    = {2019},
  doi     = {10.1038/s41380-018-0258-3},
  pmid    = {30283031},
  url     = {https://doi.org/10.1038/s41380-018-0258-3}
}

@article{barberocamps2018-29862881,
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  title   = {{Cholesterol impairs autophagy-mediated clearance of amyloid beta while promoting its secretion}},
  journal = {Autophagy},
  year    = {2018},
  doi     = {10.1080/15548627.2018.1438807},
  pmid    = {29862881},
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}

@article{camposobando2018-29766437,
  author  = {Campos-Obando, N. and Lahousse, L. and Brusselle, G. and Stricker, B. H. and Hofman, A. and Franco, O. H. and Uitterlinden, A. G. and Zillikens, M. C.},
  title   = {{Serum phosphate levels are related to all-cause, cardiovascular and COPD mortality in men}},
  journal = {European journal of epidemiology},
  year    = {2018},
  doi     = {10.1007/s10654-018-0407-7},
  pmid    = {29766437},
  url     = {https://doi.org/10.1007/s10654-018-0407-7}
}

@article{skaper2018-29618972,
  author  = {Skaper, S. D. and Facci, L. and Zusso, M. and Giusti, P.},
  title   = {{An Inflammation-Centric View of Neurological Disease: Beyond the Neuron}},
  journal = {Frontiers in cellular neuroscience},
  year    = {2018},
  doi     = {10.3389/fncel.2018.00072},
  pmid    = {29618972},
  url     = {https://doi.org/10.3389/fncel.2018.00072}
}

@article{hannan2018-29398703,
  author  = {Hannan, A. J.},
  title   = {{Tandem repeats mediating genetic plasticity in health and disease}},
  journal = {Nature reviews. Genetics},
  year    = {2018},
  doi     = {10.1038/nrg.2017.115},
  pmid    = {29398703},
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}

@article{lemoine2017-29229003,
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  title   = {{Comparative binding properties of the tau PET tracers THK5117, THK5351, PBB3, and T807 in postmortem Alzheimer brains}},
  journal = {Alzheimer's research \& therapy},
  year    = {2017},
  doi     = {10.1186/s13195-017-0325-z},
  pmid    = {29229003},
  url     = {https://doi.org/10.1186/s13195-017-0325-z}
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@article{fahrenhold2018-28987033,
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  title   = {{TREM2 expression in the human brain: a marker of monocyte recruitment?}},
  journal = {Brain pathology (Zurich, Switzerland)},
  year    = {2018},
  doi     = {10.1111/bpa.12564},
  pmid    = {28987033},
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@article{calderon2017-29106824,
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  title   = {{Inferring Relevant Cell Types for Complex Traits by Using Single-Cell Gene Expression}},
  journal = {American journal of human genetics},
  year    = {2017},
  doi     = {10.1016/j.ajhg.2017.09.009},
  pmid    = {29106824},
  url     = {https://doi.org/10.1016/j.ajhg.2017.09.009}
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@article{choi2018-28775201,
  author  = {Choi, J. Y. and Cho, H. and Ahn, S. J. and Lee, J. H. and Ryu, Y. H. and Lee, M. S. and Lyoo, C. H.},
  title   = {{Off-Target 18F-AV-1451 Binding in the Basal Ganglia Correlates with Age-Related Iron Accumulation}},
  journal = {Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year    = {2018},
  doi     = {10.2967/jnumed.117.195248},
  pmid    = {28775201},
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@article{ramirez2017-28729832,
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  title   = {{The Role of Microglia in Retinal Neurodegeneration: Alzheimer's Disease, Parkinson, and Glaucoma}},
  journal = {Frontiers in aging neuroscience},
  year    = {2017},
  doi     = {10.3389/fnagi.2017.00214},
  pmid    = {28729832},
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@article{tabei2017-28638338,
  author  = {Tabei, K. I. and Satoh, M. and Ogawa, J. I. and Tokita, T. and Nakaguchi, N. and Nakao, K. and Kida, H. and Tomimoto, H.},
  title   = {{Physical Exercise with Music Reduces Gray and White Matter Loss in the Frontal Cortex of Elderly People: The Mihama-Kiho Scan Project}},
  journal = {Frontiers in aging neuroscience},
  year    = {2017},
  doi     = {10.3389/fnagi.2017.00174},
  pmid    = {28638338},
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@article{he2017-28579942,
  author  = {He, X. F. and Liu, D. X. and Zhang, Q. and Liang, F. Y. and Dai, G. Y. and Zeng, J. S. and Pei, Z. and Xu, G. Q. and others},
  title   = {{Voluntary Exercise Promotes Glymphatic Clearance of Amyloid Beta and Reduces the Activation of Astrocytes and Microglia in Aged Mice}},
  journal = {Frontiers in molecular neuroscience},
  year    = {2017},
  doi     = {10.3389/fnmol.2017.00144},
  pmid    = {28579942},
  url     = {https://doi.org/10.3389/fnmol.2017.00144}
}

@article{kirkley2017-28476157,
  author  = {Kirkley, K. S. and Popichak, K. A. and Afzali, M. F. and Legare, M. E. and Tjalkens, R. B.},
  title   = {{Microglia amplify inflammatory activation of astrocytes in manganese neurotoxicity}},
  journal = {Journal of neuroinflammation},
  year    = {2017},
  doi     = {10.1186/s12974-017-0871-0},
  pmid    = {28476157},
  url     = {https://doi.org/10.1186/s12974-017-0871-0}
}

@article{kober2017-28432014,
  author  = {Kober, D. L. and Brett, T. J.},
  title   = {{TREM2-Ligand Interactions in Health and Disease}},
  journal = {Journal of molecular biology},
  year    = {2017},
  doi     = {10.1016/j.jmb.2017.04.004},
  pmid    = {28432014},
  url     = {https://doi.org/10.1016/j.jmb.2017.04.004}
}

@article{nobuhara2017-28408124,
  author  = {Nobuhara, C. K. and DeVos, S. L. and Commins, C. and Wegmann, S. and Moore, B. D. and Roe, A. D. and Costantino, I. and Frosch, M. P. and others},
  title   = {{Tau Antibody Targeting Pathological Species Blocks Neuronal Uptake and Interneuron Propagation of Tau in Vitro}},
  journal = {The American journal of pathology},
  year    = {2017},
  doi     = {10.1016/j.ajpath.2017.01.022},
  pmid    = {28408124},
  url     = {https://doi.org/10.1016/j.ajpath.2017.01.022}
}

@article{mcmanus2017-28259169,
  author  = {McManus, R. M. and Heneka, M. T.},
  title   = {{Role of neuroinflammation in neurodegeneration: new insights}},
  journal = {Alzheimer's research \& therapy},
  year    = {2017},
  doi     = {10.1186/s13195-017-0241-2},
  pmid    = {28259169},
  url     = {https://doi.org/10.1186/s13195-017-0241-2}
}

@article{takahashi2017-28070672,
  author  = {Takahashi, H. and Klein, Z. A. and Bhagat, S. M. and Kaufman, A. C. and Kostylev, M. A. and Ikezu, T. and Strittmatter, S. M. and {Alzheimer’s Disease Neuroimaging Initiative}},
  title   = {{Opposing effects of progranulin deficiency on amyloid and tau pathologies via microglial TYROBP network}},
  journal = {Acta neuropathologica},
  year    = {2017},
  doi     = {10.1007/s00401-017-1668-z},
  pmid    = {28070672},
  url     = {https://doi.org/10.1007/s00401-017-1668-z}
}

@article{tarantini2017-27845201,
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  title   = {{Impaired neurovascular coupling in aging and Alzheimer's disease: Contribution of astrocyte dysfunction and endothelial impairment to cognitive decline}},
  journal = {Experimental gerontology},
  year    = {2017},
  doi     = {10.1016/j.exger.2016.11.004},
  pmid    = {27845201},
  url     = {https://doi.org/10.1016/j.exger.2016.11.004}
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@article{varga2016-27568802,
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  title   = {{Reduced Slow-Wave Sleep Is Associated with High Cerebrospinal Fluid Aβ42 Levels in Cognitively Normal Elderly}},
  journal = {Sleep},
  year    = {2016},
  doi     = {10.5665/sleep.6240},
  pmid    = {27568802},
  url     = {https://doi.org/10.5665/sleep.6240}
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@article{raju2016-27803687,
  author  = {Raju, H. B. and Tsinoremas, N. F. and Capobianco, E.},
  title   = {{Emerging Putative Associations between Non-Coding RNAs and Protein-Coding Genes in Neuropathic Pain: Added Value from Reusing Microarray Data}},
  journal = {Frontiers in neurology},
  year    = {2016},
  doi     = {10.3389/fneur.2016.00168},
  pmid    = {27803687},
  url     = {https://doi.org/10.3389/fneur.2016.00168}
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@article{daerr2017-28138429,
  author  = {Daerr, S. and Brendel, M. and Zach, C. and Mille, E. and Schilling, D. and Zacherl, M. J. and Bürger, K. and Danek, A. and others},
  title   = {{Evaluation of early-phase [18F]-florbetaben PET acquisition in clinical routine cases}},
  journal = {NeuroImage. Clinical},
  year    = {2017},
  doi     = {10.1016/j.nicl.2016.10.005},
  pmid    = {28138429},
  url     = {https://doi.org/10.1016/j.nicl.2016.10.005}
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@article{kobayashi2016-27798193,
  author  = {Kobayashi, M. and Konishi, H. and Sayo, A. and Takai, T. and Kiyama, H.},
  title   = {{TREM2/DAP12 Signal Elicits Proinflammatory Response in Microglia and Exacerbates Neuropathic Pain}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2016},
  doi     = {10.1523/jneurosci.1238-16.2016},
  pmid    = {27798193},
  url     = {https://doi.org/10.1523/jneurosci.1238-16.2016}
}

@article{xiang2016-27402340,
  author  = {Xiang, X. and Werner, G. and Bohrmann, B. and Liesz, A. and Mazaheri, F. and Capell, A. and Feederle, R. and Knuesel, I. and others},
  title   = {{TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance}},
  journal = {EMBO molecular medicine},
  year    = {2016},
  doi     = {10.15252/emmm.201606370},
  pmid    = {27402340},
  url     = {https://doi.org/10.15252/emmm.201606370}
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@article{bereczki2016-27224930,
  author  = {Bereczki, E. and Francis, P. T. and Howlett, D. and Pereira, J. B. and Höglund, K. and Bogstedt, A. and Cedazo-Minguez, A. and Baek, J. H. and others},
  title   = {{Synaptic proteins predict cognitive decline in Alzheimer's disease and Lewy body dementia}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2016},
  doi     = {10.1016/j.jalz.2016.04.005},
  pmid    = {27224930},
  url     = {https://doi.org/10.1016/j.jalz.2016.04.005}
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@article{zheng2016-27143430,
  author  = {Zheng, H. and Liu, C. C. and Atagi, Y. and Chen, X. F. and Jia, L. and Yang, L. and He, W. and Zhang, X. and others},
  title   = {{Opposing roles of the triggering receptor expressed on myeloid cells 2 and triggering receptor expressed on myeloid cells-like transcript 2 in microglia activation}},
  journal = {Neurobiology of aging},
  year    = {2016},
  doi     = {10.1016/j.neurobiolaging.2016.03.004},
  pmid    = {27143430},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2016.03.004}
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@article{chen2016-26935478,
  author  = {Chen, W. W. and Zhang, X. and Huang, W. J.},
  title   = {{Role of neuroinflammation in neurodegenerative diseases (Review)}},
  journal = {Molecular medicine reports},
  year    = {2016},
  doi     = {10.3892/mmr.2016.4948},
  pmid    = {26935478},
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@article{cavallari2016-26920674,
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  title   = {{Neural substrates of vulnerability to postsurgical delirium as revealed by presurgical diffusion MRI}},
  journal = {Brain : a journal of neurology},
  year    = {2016},
  doi     = {10.1093/brain/aww010},
  pmid    = {26920674},
  url     = {https://doi.org/10.1093/brain/aww010}
}

@article{paillusson2016-26899735,
  author  = {Paillusson, S. and Stoica, R. and Gomez-Suaga, P. and Lau, D. H. W. and Mueller, S. and Miller, T. and Miller, C. C. J.},
  title   = {{There's Something Wrong with my MAM; the ER-Mitochondria Axis and Neurodegenerative Diseases}},
  journal = {Trends in neurosciences},
  year    = {2016},
  doi     = {10.1016/j.tins.2016.01.008},
  pmid    = {26899735},
  url     = {https://doi.org/10.1016/j.tins.2016.01.008}
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@article{jiang2016-26802771,
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  title   = {{TREM2 modifies microglial phenotype and provides neuroprotection in P301S tau transgenic mice}},
  journal = {Neuropharmacology},
  year    = {2016},
  doi     = {10.1016/j.neuropharm.2016.01.028},
  pmid    = {26802771},
  url     = {https://doi.org/10.1016/j.neuropharm.2016.01.028}
}

@article{heywood2015-26627638,
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  title   = {{Identification of novel CSF biomarkers for neurodegeneration and their validation by a high-throughput multiplexed targeted proteomic assay}},
  journal = {Molecular neurodegeneration},
  year    = {2015},
  doi     = {10.1186/s13024-015-0059-y},
  pmid    = {26627638},
  url     = {https://doi.org/10.1186/s13024-015-0059-y}
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@article{schmidburgk2016-26553871,
  author  = {Schmid-Burgk, J. L. and Chauhan, D. and Schmidt, T. and Ebert, T. S. and Reinhardt, J. and Endl, E. and Hornung, V.},
  title   = {{A Genome-wide CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) Screen Identifies NEK7 as an Essential Component of NLRP3 Inflammasome Activation}},
  journal = {The Journal of biological chemistry},
  year    = {2016},
  doi     = {10.1074/jbc.c115.700492},
  pmid    = {26553871},
  url     = {https://doi.org/10.1074/jbc.c115.700492}
}

@article{jiang2015-26364736,
  author  = {Jiang, T. and Tan, L. and Zhu, X. C. and Zhou, J. S. and Cao, L. and Tan, M. S. and Wang, H. F. and Chen, Q. and others},
  title   = {{Silencing of TREM2 exacerbates tau pathology, neurodegenerative changes, and spatial learning deficits in P301S tau transgenic mice}},
  journal = {Neurobiology of aging},
  year    = {2015},
  doi     = {10.1016/j.neurobiolaging.2015.08.019},
  pmid    = {26364736},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2015.08.019}
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@article{paumier2015-26093169,
  author  = {Paumier, K. L. and Luk, K. C. and Manfredsson, F. P. and Kanaan, N. M. and Lipton, J. W. and Collier, T. J. and Steece-Collier, K. and Kemp, C. J. and others},
  title   = {{Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration}},
  journal = {Neurobiology of disease},
  year    = {2015},
  doi     = {10.1016/j.nbd.2015.06.003},
  pmid    = {26093169},
  url     = {https://doi.org/10.1016/j.nbd.2015.06.003}
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@article{mckee2015-25904048,
  author  = {McKee, A. C. and Stein, T. D. and Kiernan, P. T. and Alvarez, V. E.},
  title   = {{The neuropathology of chronic traumatic encephalopathy}},
  journal = {Brain pathology (Zurich, Switzerland)},
  year    = {2015},
  doi     = {10.1111/bpa.12248},
  pmid    = {25904048},
  url     = {https://doi.org/10.1111/bpa.12248}
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@article{savage2015-25904803,
  author  = {Savage, J. C. and Jay, T. and Goduni, E. and Quigley, C. and Mariani, M. M. and Malm, T. and Ransohoff, R. M. and Lamb, B. T. and others},
  title   = {{Nuclear receptors license phagocytosis by trem2+ myeloid cells in mouse models of Alzheimer's disease}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2015},
  doi     = {10.1523/jneurosci.4586-14.2015},
  pmid    = {25904803},
  url     = {https://doi.org/10.1523/jneurosci.4586-14.2015}
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@article{kaushal2015-25744023,
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  title   = {{Neuronal NLRP1 inflammasome activation of Caspase-1 coordinately regulates inflammatory interleukin-1-beta production and axonal degeneration-associated Caspase-6 activation}},
  journal = {Cell death and differentiation},
  year    = {2015},
  doi     = {10.1038/cdd.2015.16},
  pmid    = {25744023},
  url     = {https://doi.org/10.1038/cdd.2015.16}
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@article{ayton2015-25716857,
  author  = {Ayton, S. and Lei, P. and Hare, D. J. and Duce, J. A. and George, J. L. and Adlard, P. A. and McLean, C. and Rogers, J. T. and others},
  title   = {{Parkinson's disease iron deposition caused by nitric oxide-induced loss of β-amyloid precursor protein}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2015},
  doi     = {10.1523/jneurosci.3439-14.2015},
  pmid    = {25716857},
  url     = {https://doi.org/10.1523/jneurosci.3439-14.2015}
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@article{hick2015-25432317,
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  title   = {{Acute function of secreted amyloid precursor protein fragment APPsα in synaptic plasticity}},
  journal = {Acta neuropathologica},
  year    = {2015},
  doi     = {10.1007/s00401-014-1368-x},
  pmid    = {25432317},
  url     = {https://doi.org/10.1007/s00401-014-1368-x}
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@article{liguori2015-25121572,
  author  = {Liguori, C. and Stefani, A. and Sancesario, G. and Sancesario, G. M. and Marciani, M. G. and Pierantozzi, M.},
  title   = {{CSF lactate levels, τ proteins, cognitive decline: a dynamic relationship in Alzheimer's disease}},
  journal = {Journal of neurology, neurosurgery, and psychiatry},
  year    = {2015},
  doi     = {10.1136/jnnp-2014-308577},
  pmid    = {25121572},
  url     = {https://doi.org/10.1136/jnnp-2014-308577}
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@article{cabezas2014-25136294,
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  title   = {{Astrocytic modulation of blood brain barrier: perspectives on Parkinson's disease}},
  journal = {Frontiers in cellular neuroscience},
  year    = {2014},
  doi     = {10.3389/fncel.2014.00211},
  pmid    = {25136294},
  url     = {https://doi.org/10.3389/fncel.2014.00211}
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@article{mandler2014-24525765,
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  title   = {{Next-generation active immunization approach for synucleinopathies: implications for Parkinson's disease clinical trials}},
  journal = {Acta neuropathologica},
  year    = {2014},
  doi     = {10.1007/s00401-014-1256-4},
  pmid    = {24525765},
  url     = {https://doi.org/10.1007/s00401-014-1256-4}
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@article{lewis2014-24318290,
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@article{chai2026-41884592,
  author  = {Chai, Yuek Ling and Hilal, Saima and Cai, Vera Yuan and Mok, Vincent C. T. and Chong, Joyce Ruifen and Liao, Yingqi and Tan, Boon Yeow and Venketasubramanian, Narayanaswamy and others},
  title   = {{Elevated serum inflammasome adaptor protein ASC is associated with white matter hyperintensities in vascular cognitive impairment}},
  journal = {Brain Communications},
  year    = {2026},
  doi     = {10.1093/braincomms/fcag068},
  pmid    = {41884592},
  url     = {https://doi.org/10.1093/braincomms/fcag068}
}

@article{zhou2025-41346438,
  author  = {Zhou, Su and Kuai, Jun and Yi, Tingting and Wu, Hao and Gan, Jinghuan and Shi, Zhihong and Liu, Shuai and Ji, Yong Il},
  title   = {{Delineation of the cognitive and neuropsychiatric features of Pisa syndrome in dementia with Lewy bodies}},
  journal = {Frontiers in Aging Neuroscience},
  year    = {2025},
  doi     = {10.3389/fnagi.2025.1637930},
  pmid    = {41346438},
  url     = {https://doi.org/10.3389/fnagi.2025.1637930}
}

@article{sekiya2025-41185066,
  author  = {Sekiya, Hiroaki and Matsubara, Tomoyasu and Deture, Michael A. and Dickson, Dennis W.},
  title   = {{Neuropathology of Lewy body dementia: Lewy-related pathology, α-synuclein oligomers, and comorbid pathologies}},
  journal = {Molecular Neurodegeneration},
  year    = {2025},
  doi     = {10.1186/s13024-025-00900-6},
  pmid    = {41185066},
  url     = {https://doi.org/10.1186/s13024-025-00900-6}
}

@article{krogsaeter2025-41103078,
  author  = {Krogsaeter, Einar Kleinhans and McKetney, Justin and Valiente‐Banuet, Leopoldo and Marquez, Angelica and Willis, Alexandra R. and Cakir, Zeynep and Stevenson, Erica J. and Jang, Gwendolyn Μ. and others},
  title   = {{Lysosomal proteomics reveals mechanisms of neuronal APOE4-associated lysosomal dysfunction}},
  journal = {Autophagy},
  year    = {2025},
  doi     = {10.1080/15548627.2025.2576613},
  pmid    = {41103078},
  url     = {https://doi.org/10.1080/15548627.2025.2576613}
}

@article{lee2025-01baa622,
  author  = {Lee, Wen-Teng},
  title   = {{GLP-1 Receptor Agonists Reduce Dementia and Alzheimer Disease Risk in Patients with Diabetes and Advanced CKD: Real-World Evidence from TriNetX}},
  journal = {Journal of the American Society of Nephrology},
  year    = {2025},
  doi     = {10.1681/asn.2025rdy8v05v},
  url     = {https://doi.org/10.1681/asn.2025rdy8v05v}
}

@article{terrabuio2025-40993111,
  author  = {Terrabuio, E. and Pietronigro, E. C. and Bani, A. and Della Bianca, V. and Laudanna, C. and Rossi, B. and Finotti, G. and Santos-Lima, B. and Zenaro, E. and Turano, E. and Tosadori, G. and Calgaro, M. and others},
  title   = {{CD103-CD8+ T cells promote neurotoxic inflammation in Alzheimer's disease via granzyme K-PAR-1 signaling}},
  journal = {Nature Communications},
  year    = {2025},
  doi     = {10.1038/s41467-025-62405-6},
  pmid    = {40993111},
  url     = {https://doi.org/10.1038/s41467-025-62405-6}
}

@article{lenoel2025-40858618,
  author  = {Lenoël, Isadora and Ribon, Matthieu and Lorenc, Félicie and Diebold, Aurélien and Philibert, Clémentine Eva and Robaldo, David and Badsi, Manel and Perronnet, Julianne and others},
  title   = {{ALS/FTD-linked TBK1 deficiency in microglia induces an aged-like microglial signature and drives social recognition deficits in mice}},
  journal = {Nature Communications},
  year    = {2025},
  doi     = {10.1038/s41467-025-63211-w},
  pmid    = {40858618},
  url     = {https://doi.org/10.1038/s41467-025-63211-w}
}

@article{verstappen2025-40757800,
  author  = {Verstappen, Damon and de Jong, Joost J.A. and Voorter, Paulien and van Dinther, Maud and van Oostenbrugge, Robert J. and Staals, Julie and Jansen, Jacobus F.A. and Backes, Walter H.},
  title   = {{DCE-MRI reveals spatial pattern in heterogeneous blood-brain barrier leakage within white matter in cerebral small vessel disease}},
  journal = {Journal of Cerebral Blood Flow \& Metabolism},
  year    = {2025},
  doi     = {10.1177/0271678x251364151},
  pmid    = {40757800},
  url     = {https://doi.org/10.1177/0271678x251364151}
}

@article{ozdemir2025-40735406,
  author  = {ÖZDEMİR, Kübra and Demir, Yeliz},
  title   = {{Phenolic Compounds in Exercise Physiology: Dual Role in Oxidative Stress and Recovery Adaptation}},
  journal = {Food Science \& Nutrition},
  year    = {2025},
  doi     = {10.1002/fsn3.70714},
  pmid    = {40735406},
  url     = {https://doi.org/10.1002/fsn3.70714}
}

@article{gezegen2025-40613333,
  author  = {Gezegen, Haşim and Alaylıoğlu, Merve and Şahin, Erdi and Swann, Owen and Veleva, Elena and Guven, Gamze Senol and Yaman, Ümran and Salih, Dervis A. M. and others},
  title   = {{Unravelling the plasma proteome: Pioneering biomarkers for differential dementia diagnosis}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz.70162},
  pmid    = {40613333},
  url     = {https://doi.org/10.1002/alz.70162}
}

@article{mahammedi2025-40506229,
  author  = {Mahammedi, Abdelkader and Fettahoglu, Ates and Heit, Jeremy Josef and Wardlaw, Joanna Marguerite and Zaharchuk, Greg},
  title   = {{Arterial Spin-Labeling MRI Identifies Abnormal Perfusion Metric at the Gray Matter/CSF Interface in Cerebral Small Vessel Disease}},
  journal = {American Journal of Neuroradiology},
  year    = {2025},
  doi     = {10.3174/ajnr.a8682},
  pmid    = {40506229},
  url     = {https://doi.org/10.3174/ajnr.a8682}
}

@article{hein2025-40322968,
  author  = {Hein, Zaw Myo and Nassir, Che Mohd Nasril Che Mohd and Ramli, Muhammad Danial Che and Jaffer, Usman and Mehat, Muhammad Zulfadli and Mustapha, Muzaimi and Hamid, Hafizah Abdul},
  title   = {{Cerebral small vessel disease: The impact of glymphopathy and sleep disorders}},
  journal = {Journal of Cerebral Blood Flow \& Metabolism},
  year    = {2025},
  doi     = {10.1177/0271678x251333933},
  pmid    = {40322968},
  url     = {https://doi.org/10.1177/0271678x251333933}
}

@article{saari2025-40352683,
  author  = {Saari, Toni Tapani and Palviainen, Teemu and Hiltunen, Mikko O. and Herukka, Sanna‐Kaisa and Kokkola, Tarja and Kärkkäinen, Sari and Urjansson, Mia and Aaltonen, Aino and others},
  title   = {{Cross‐sectional study of plasma phosphorylated tau 217 in persons without dementia}},
  journal = {Alzheimer s \& Dementia Diagnosis Assessment \& Disease Monitoring},
  year    = {2025},
  doi     = {10.1002/dad2.70107},
  pmid    = {40352683},
  url     = {https://doi.org/10.1002/dad2.70107}
}

@article{li2025-40218880,
  author  = {Li, Mengyan and Ren, Ruodi and Wang, Kunkun and Wang, Shan and Chow, Andrew and Yang, Andrew and Lu, Yun and Leo, Christopher},
  title   = {{Effects of B Vitamins on Homocysteine Lowering and Thrombotic Risk Reduction—A Review of Randomized Controlled Trials Published Since January 1996}},
  journal = {Nutrients},
  year    = {2025},
  doi     = {10.3390/nu17071122},
  pmid    = {40218880},
  url     = {https://doi.org/10.3390/nu17071122}
}

@article{tunali2025-40081955,
  author  = {Tunali, Ilke and Wang, Jian and Arora, Anupa and Kim, Min Jung and Shcherbinin, Sergey and Pontecorvo, Michael J. and Iaccarino, Leonardo},
  title   = {{Development and Validation of a 18 F-Flortaucipir PET Visual Stratification Method}},
  journal = {Journal of Nuclear Medicine},
  year    = {2025},
  doi     = {10.2967/jnumed.124.268700},
  pmid    = {40081955},
  url     = {https://doi.org/10.2967/jnumed.124.268700}
}

@article{simon2025-40134937,
  author  = {Simon, Christopher and Graves, Occam Kelly and Akeju, Oluwaseun and McKay, Tina B.},
  title   = {{Elevated TDP-43 serum levels associated with postoperative delirium following major cardiac surgery}},
  journal = {Brain Behavior \& Immunity - Health},
  year    = {2025},
  doi     = {10.1016/j.bbih.2025.100974},
  pmid    = {40134937},
  url     = {https://doi.org/10.1016/j.bbih.2025.100974}
}

@article{hazelton2025-39987747,
  author  = {Hazelton, Jessica L. and Della Bella, Gabriel A. and Barttfeld, Pablo and Dottori, Martín and González-Gómez, Raúl and Migeot, Joaquín and Moguilner, Sebastián and Legaz, Agustina and others},
  title   = {{Altered spatiotemporal brain dynamics of interoception in behavioural-variant frontotemporal dementia}},
  journal = {EBioMedicine},
  year    = {2025},
  doi     = {10.1016/j.ebiom.2025.105614},
  pmid    = {39987747},
  url     = {https://doi.org/10.1016/j.ebiom.2025.105614}
}

@article{vandijk2025-39950450,
  author  = {van Dijk, Suzanne E. and Drenth, Nadieh and Hafkemeijer, Anne and Labadie, Gerda and Witjes‐Ané, Marie‐Noëlle W. and Baas, Frank F. and Vreijling, Jeroen P. and Blauw, Gerard J. and others},
  title   = {{Neurovascular Decoupling Is Associated With Lobar Intracerebral Hemorrhages and White Matter Hyperintensities}},
  journal = {Journal of the American Heart Association},
  year    = {2025},
  doi     = {10.1161/jaha.124.038819},
  pmid    = {39950450},
  url     = {https://doi.org/10.1161/jaha.124.038819}
}

@article{huang2025-39921653,
  author  = {Huang, Yixuan and Shang, Li and Li, Bo and Wang, Tianyi and Zhang, Xiao and Wei, Junji and Mao, Chenhui and Gao, Jing},
  title   = {{Normal pressure hydrocephalus combined with quadruple misfolded proteinopathy: An autopsy case report and a short review of literature}},
  journal = {Journal of Neuropathology \& Experimental Neurology},
  year    = {2025},
  doi     = {10.1093/jnen/nlaf006},
  pmid    = {39921653},
  url     = {https://doi.org/10.1093/jnen/nlaf006}
}

@article{chen2025-39863325,
  author  = {Chen, James Xiao Yuan and Vipin, Ashwati and Sandhu, Gurveen Kaur and Leow, Yi Jin and Zailan, Fatin Zahra and Tanoto, Pricilia and Lee, Ee Soo and Lee, Khang Leng and others},
  title   = {{Blood-brain barrier integrity disruption is associated with both chronic vascular risk factors and white matter hyperintensities}},
  journal = {The Journal of Prevention of Alzheimer s Disease},
  year    = {2025},
  doi     = {10.1016/j.tjpad.2024.100029},
  pmid    = {39863325},
  url     = {https://doi.org/10.1016/j.tjpad.2024.100029}
}

@article{xiang2025-39757220,
  author  = {Xiang, Jie and Zhang, Zhentao and Wu, Shengxi and Ye, Keqiang},
  title   = {{Positron emission tomography tracers for synucleinopathies}},
  journal = {Molecular Neurodegeneration},
  year    = {2025},
  doi     = {10.1186/s13024-024-00787-9},
  pmid    = {39757220},
  url     = {https://doi.org/10.1186/s13024-024-00787-9}
}

@article{ferrara2025-40354379,
  author  = {Ferrara, María Cristina and Lozano-Vicario, Lucía and Arosio, Beatrice and D’Orlando, Cristina and De Luca, Lara and Ornago, Alice Margherita and Pinardi, Elena and Mazzola, Paolo and others},
  title   = {{Neurofilament-Light Chain and Glial Fibrillary Acidic Protein as Blood-Based Delirium Risk Markers: A Multicohort Study}},
  journal = {Aging and Disease},
  year    = {2025},
  doi     = {10.14336/ad.2025.0107},
  pmid    = {40354379},
  url     = {https://doi.org/10.14336/ad.2025.0107}
}

@article{decaix2025-40249931,
  author  = {Decaix, Théodore and Lilamand, Matthieu and Götze, Karl and Mouton‐Liger, François and Cognat, Emmanuel and Hugon, Jacques and Bouaziz-Amar, Élodie and Sindzingre, Louise and others},
  title   = {{Unraveling Homocysteine's Role in Dementia: No Specific Association with Alzheimer's Disease, but a Connection to White Matter Hyperintensities}},
  journal = {Aging and Disease},
  year    = {2025},
  doi     = {10.14336/ad.225.0020},
  pmid    = {40249931},
  url     = {https://doi.org/10.14336/ad.225.0020}
}

@article{wu2024-39560478,
  author  = {Wu, J. and Li, B. and Wang, J. and Huang, Q. and Chen, X. and You, Z. and He, K. and Guo, Q. and others},
  title   = {{Plasma Glial Fibrillary Acid Protein and Phosphorated Tau 181 Association with Presynaptic Density-Dependent Tau Pathology at 18F-SynVesT-1 Brain PET Imaging}},
  journal = {Radiology},
  year    = {2024},
  doi     = {10.1148/radiol.233019},
  pmid    = {39560478},
  url     = {https://doi.org/10.1148/radiol.233019}
}

@article{cui2024-38849370,
  author  = {Cui, Y. and Chen, C. and Tang, Z. and Yuan, W. and Yue, K. and Cui, P. and Qiu, X. and Zhang, H. and others},
  title   = {{TREM2 deficiency aggravates renal injury by promoting macrophage apoptosis and polarization via the JAK-STAT pathway in mice}},
  journal = {Cell death \& disease},
  year    = {2024},
  doi     = {10.1038/s41419-024-06756-w},
  pmid    = {38849370},
  url     = {https://doi.org/10.1038/s41419-024-06756-w}
}

@article{patterson2024-38695172,
  author  = {Patterson, M. T. and Xu, Y. and Hillman, H. and Osinski, V. and Schrank, P. R. and Kennedy, A. E. and Barrow, F. and Zhu, A. and others},
  title   = {{Trem2 Agonist Reprograms Foamy Macrophages to Promote Atherosclerotic Plaque Stability-Brief Report}},
  journal = {Arteriosclerosis, thrombosis, and vascular biology},
  year    = {2024},
  doi     = {10.1161/atvbaha.124.320797},
  pmid    = {38695172},
  url     = {https://doi.org/10.1161/atvbaha.124.320797}
}

@article{holscher2024-38677445,
  author  = {Hölscher, C.},
  title   = {{Glucagon-like peptide-1 class drugs show clear protective effects in Parkinson's and Alzheimer's disease clinical trials: A revolution in the making?}},
  journal = {Neuropharmacology},
  year    = {2024},
  doi     = {10.1016/j.neuropharm.2024.109952},
  pmid    = {38677445},
  url     = {https://doi.org/10.1016/j.neuropharm.2024.109952}
}

@article{zhou2024-38478630,
  author  = {Zhou, L. and Qiu, X. and Meng, Z. and Liu, T. and Chen, Z. and Zhang, P. and Kuang, H. and Pan, T. and others},
  title   = {{Hepatic danger signaling triggers TREM2+ macrophage induction and drives steatohepatitis via MS4A7-dependent inflammasome activation}},
  journal = {Science translational medicine},
  year    = {2024},
  doi     = {10.1126/scitranslmed.adk1866},
  pmid    = {38478630},
  url     = {https://doi.org/10.1126/scitranslmed.adk1866}
}

@article{terzioglu2023-38017562,
  author  = {Terzioglu, G. and Young-Pearse, T. L.},
  title   = {{Microglial function, INPP5D/SHIP1 signaling, and NLRP3 inflammasome activation: implications for Alzheimer's disease}},
  journal = {Molecular neurodegeneration},
  year    = {2023},
  doi     = {10.1186/s13024-023-00674-9},
  pmid    = {38017562},
  url     = {https://doi.org/10.1186/s13024-023-00674-9}
}

@article{hussong2023-37185259,
  author  = {Hussong, S. A. and Banh, A. Q. and Van Skike, C. E. and Dorigatti, A. O. and Hernandez, S. F. and Hart, M. J. and Ferran, B. and Makhlouf, H. and others},
  title   = {{Soluble pathogenic tau enters brain vascular endothelial cells and drives cellular senescence and brain microvascular dysfunction in a mouse model of tauopathy}},
  journal = {Nature communications},
  year    = {2023},
  doi     = {10.1038/s41467-023-37840-y},
  pmid    = {37185259},
  url     = {https://doi.org/10.1038/s41467-023-37840-y}
}

@article{knopman2023-36948153,
  author  = {Knopman, D. S.},
  title   = {{Lecanemab reduces brain amyloid-β and delays cognitive worsening}},
  journal = {Cell reports. Medicine},
  year    = {2023},
  doi     = {10.1016/j.xcrm.2023.100982},
  pmid    = {36948153},
  url     = {https://doi.org/10.1016/j.xcrm.2023.100982}
}

@article{vitek2023-36749830,
  author  = {Vitek, G. E. and Decourt, B. and Sabbagh, M. N.},
  title   = {{Lecanemab (BAN2401): an anti-beta-amyloid monoclonal antibody for the treatment of Alzheimer disease}},
  journal = {Expert opinion on investigational drugs},
  year    = {2023},
  doi     = {10.1080/13543784.2023.2178414},
  pmid    = {36749830},
  url     = {https://doi.org/10.1080/13543784.2023.2178414}
}

@article{thomas2022-36376530,
  author  = {Thomas, A. L. and Lehn, M. A. and Janssen, E. M. and Hildeman, D. A. and Chougnet, C. A.},
  title   = {{Naturally-aged microglia exhibit phagocytic dysfunction accompanied by gene expression changes reflective of underlying neurologic disease}},
  journal = {Scientific reports},
  year    = {2022},
  doi     = {10.1038/s41598-022-21920-y},
  pmid    = {36376530},
  url     = {https://doi.org/10.1038/s41598-022-21920-y}
}

@article{wood2022-36417868,
  author  = {Wood, J. I. and Wong, E. and Joghee, R. and Balbaa, A. and Vitanova, K. S. and Stringer, K. M. and Vanshoiack, A. and Phelan, S. J. and others},
  title   = {{Plaque contact and unimpaired Trem2 is required for the microglial response to amyloid pathology}},
  journal = {Cell reports},
  year    = {2022},
  doi     = {10.1016/j.celrep.2022.111686},
  pmid    = {36417868},
  url     = {https://doi.org/10.1016/j.celrep.2022.111686}
}

@article{lu2022-36411661,
  author  = {Lu, Y. P. and Wu, H. W. and Zhu, T. and Li, X. T. and Zuo, J. and Hasan, A. A. and Reichetzeder, C. and Delic, D. and others},
  title   = {{Empagliflozin reduces kidney fibrosis and improves kidney function by alternative macrophage activation in rats with 5/6-nephrectomy}},
  journal = {Biomedicine \& pharmacotherapy = Biomedecine \& pharmacotherapie},
  year    = {2022},
  doi     = {10.1016/j.biopha.2022.113947},
  pmid    = {36411661},
  url     = {https://doi.org/10.1016/j.biopha.2022.113947}
}

@article{cupido2022-35921096,
  author  = {Cupido, A. J. and Reeskamp, L. F. and Hingorani, A. D. and Finan, C. and Asselbergs, F. W. and Hovingh, G. K. and Schmidt, A. F.},
  title   = {{Joint Genetic Inhibition of PCSK9 and CETP and the Association With Coronary Artery Disease: A Factorial Mendelian Randomization Study}},
  journal = {JAMA cardiology},
  year    = {2022},
  doi     = {10.1001/jamacardio.2022.2333},
  pmid    = {35921096},
  url     = {https://doi.org/10.1001/jamacardio.2022.2333}
}

@article{liu2022-35712121,
  author  = {Liu, Z. and Gao, Z. and Li, B. and Li, J. and Ou, Y. and Yu, X. and Zhang, Z. and Liu, S. and others},
  title   = {{Lipid-associated macrophages in the tumor-adipose microenvironment facilitate breast cancer progression}},
  journal = {Oncoimmunology},
  year    = {2022},
  doi     = {10.1080/2162402x.2022.2085432},
  pmid    = {35712121},
  url     = {https://doi.org/10.1080/2162402x.2022.2085432}
}

@article{shi2022-35672148,
  author  = {Shi, Q. and Chang, C. and Saliba, A. and Bhat, M. A.},
  title   = {{Microglial mTOR Activation Upregulates Trem2 and Enhances β-Amyloid Plaque Clearance in the 5XFAD Alzheimer's Disease Model}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2022},
  doi     = {10.1523/jneurosci.2427-21.2022},
  pmid    = {35672148},
  url     = {https://doi.org/10.1523/jneurosci.2427-21.2022}
}

@article{gui2022-35498045,
  author  = {Gui, Y. and Zheng, H. and Cao, R. Y.},
  title   = {{Foam Cells in Atherosclerosis: Novel Insights Into Its Origins, Consequences, and Molecular Mechanisms}},
  journal = {Frontiers in cardiovascular medicine},
  year    = {2022},
  doi     = {10.3389/fcvm.2022.845942},
  pmid    = {35498045},
  url     = {https://doi.org/10.3389/fcvm.2022.845942}
}

@article{chu2022-34906980,
  author  = {Chu, W. T. and Wang, W. E. and Zaborszky, L. and Golde, T. E. and DeKosky, S. and Duara, R. and Loewenstein, D. A. and Adjouadi, M. and others},
  title   = {{Association of Cognitive Impairment With Free Water in the Nucleus Basalis of Meynert and Locus Coeruleus to Transentorhinal Cortex Tract}},
  journal = {Neurology},
  year    = {2022},
  doi     = {10.1212/wnl.0000000000013206},
  pmid    = {34906980},
  url     = {https://doi.org/10.1212/wnl.0000000000013206}
}

@article{soares2021-34831271,
  author  = {Soares, L. C. and Al-Dalahmah, O. and Hillis, J. and Young, C. C. and Asbed, I. and Sakaguchi, M. and O'Neill, E. and Szele, F. G.},
  title   = {{Novel Galectin-3 Roles in Neurogenesis, Inflammation and Neurological Diseases}},
  journal = {Cells},
  year    = {2021},
  doi     = {10.3390/cells10113047},
  pmid    = {34831271},
  url     = {https://doi.org/10.3390/cells10113047}
}

@article{huggins2021-34389631,
  author  = {Huggins, D. N. and LaRue, R. S. and Wang, Y. and Knutson, T. P. and Xu, Y. and Williams, J. W. and Schwertfeger, K. L.},
  title   = {{Characterizing Macrophage Diversity in Metastasis-Bearing Lungs Reveals a Lipid-Associated Macrophage Subset}},
  journal = {Cancer research},
  year    = {2021},
  doi     = {10.1158/0008-5472.can-21-0101},
  pmid    = {34389631},
  url     = {https://doi.org/10.1158/0008-5472.can-21-0101}
}

@article{schoch2021-34187891,
  author  = {Schoch, K. M. and Ezerskiy, L. A. and Morhaus, M. M. and Bannon, R. N. and Sauerbeck, A. D. and Shabsovich, M. and Jafar-Nejad, P. and Rigo, F. and others},
  title   = {{Acute Trem2 reduction triggers increased microglial phagocytosis, slowing amyloid deposition in mice}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2021},
  doi     = {10.1073/pnas.2100356118},
  pmid    = {34187891},
  url     = {https://doi.org/10.1073/pnas.2100356118}
}

@article{macdonald2021-34143756,
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  title   = {{COVID-19 and RA share an SPP1 myeloid pathway that drives PD-L1+ neutrophils and CD14+ monocytes}},
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  title   = {{Cryo-EM structures of tau filaments from Alzheimer's disease with PET ligand APN-1607}},
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  title   = {{Diet-dependent regulation of TGFβ impairs reparative innate immune responses after demyelination}},
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  title   = {{In vivo tau pathology is associated with synaptic loss and altered synaptic function}},
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  year    = {2021},
  doi     = {10.1186/s13195-021-00772-0},
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  title   = {{Engagement of TREM2 by a novel monoclonal antibody induces activation of microglia and improves cognitive function in Alzheimer's disease models}},
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  year    = {2021},
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  title   = {{Microglial activation in the right amygdala-entorhinal-hippocampal complex is associated with preserved spatial learning in AppNL-G-F mice}},
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  title   = {{Reactive or transgenic increase in microglial TYROBP reveals a TREM2-independent TYROBP-APOE link in wild-type and Alzheimer's-related mice}},
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  title   = {{Integrative Brain Transcriptome Analysis Links Complement Component 4 andHSPA2to theAPOEε2 Protective Effect in Alzheimer Disease}},
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@article{takalo2020-32917267,
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  title   = {{The Alzheimer's disease-associated protective Plcγ2-P522R variant promotes immune functions}},
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  year    = {2020},
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@article{ren2020-32579116,
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  title   = {{Microglia TREM2R47H Alzheimer-linked variant enhances excitatory transmission and reduces LTP via increased TNF-α levels}},
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@article{loving2020-32411016,
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@article{rauchmann2020-31958095,
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  title   = {{Soluble TREM2 and Inflammatory Proteins in Alzheimer's Disease Cerebrospinal Fluid}},
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@article{simpson2020-32139352,
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  title   = {{Can exercise affect immune function to increase susceptibility to infection?}},
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  year    = {2020},
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  title   = {{Depression is Associated with Tau and Not Amyloid Positron Emission Tomography in Cognitively Normal Adults}},
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  title   = {{Glucagon-Like Peptide-1: A Focus on Neurodegenerative Diseases}},
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  title   = {{A single-nuclei RNA sequencing study of Mendelian and sporadic AD in the human brain}},
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  title   = {{Functionalization of Brain Region-specific Spheroids with Isogenic Microglia-like Cells}},
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  title   = {{APOE genotype and sex affect microglial interactions with plaques in Alzheimer's disease mice}},
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  title   = {{Intranasal rapamycin ameliorates Alzheimer-like cognitive decline in a mouse model of Down syndrome}},
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  title   = {{Higher Aortic Stiffness Is Related to Lower Cerebral Blood Flow and Preserved Cerebrovascular Reactivity in Older Adults}},
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@article{rojo2018-30029164,
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  title   = {{Deficiency in the transcription factor NRF2 worsens inflammatory parameters in a mouse model with combined tauopathy and amyloidopathy}},
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@article{karch2018-29630712,
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  title   = {{Selective Genetic Overlap Between Amyotrophic Lateral Sclerosis and Diseases of the Frontotemporal Dementia Spectrum}},
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@article{head2018-29977201,
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  title   = {{Metabolic and Vascular Imaging Biomarkers in Down Syndrome Provide Unique Insights Into Brain Aging and Alzheimer Disease Pathogenesis}},
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@article{bauerl2018-29575030,
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  title   = {{Shifts in gut microbiota composition in an APP/PSS1 transgenic mouse model of Alzheimer's disease during lifespan}},
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  title   = {{Functional Studies of Missense TREM2 Mutations in Human Stem Cell-Derived Microglia}},
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@article{rangaraju2018-29552013,
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  title   = {{Differential Phagocytic Properties of CD45low Microglia and CD45high Brain Mononuclear Phagocytes-Activation and Age-Related Effects}},
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  title   = {{Behavioral and transcriptomic analysis of Trem2-null mice: not all knockout mice are created equal}},
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@article{lall2017-28737506,
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  title   = {{Microglia and C9orf72 in neuroinflammation and ALS and frontotemporal dementia}},
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  title   = {{FGF21 Attenuates High-Fat Diet-Induced Cognitive Impairment via Metabolic Regulation and Anti-inflammation of Obese Mice}},
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  title   = {{Evaluating the Patterns of Aging-Related Tau Astrogliopathy Unravels Novel Insights Into Brain Aging and Neurodegenerative Diseases}},
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  year    = {2017},
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  title   = {{Deconstructing empathy: Neuroanatomical dissociations between affect sharing and prosocial motivation using a patient lesion model}},
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  title   = {{AutoDock and AutoDockTools for Protein-Ligand Docking: Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1(BACE1) as a Case Study}},
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  title   = {{The pre-synaptic vesicle protein synaptotagmin is a novel biomarker for Alzheimer's disease}},
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  year    = {2016},
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  title   = {{Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue}},
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  title   = {{Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women}},
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  title   = {{Rutin prevents cognitive impairments by ameliorating oxidative stress and neuroinflammation in rat model of sporadic dementia of Alzheimer type}},
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@article{lee2012-22339795,
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  title   = {{Inhibitory effect of 4-O-methylhonokiol on lipopolysaccharide-induced neuroinflammation, amyloidogenesis and memory impairment via inhibition of nuclear factor-kappaB in vitro and in vivo models}},
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@article{yuyama2012-22303002,
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  title   = {{Sphingolipid-modulated exosome secretion promotes clearance of amyloid-β by microglia}},
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  year    = {2012},
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@article{mori2012-22219198,
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  title   = {{Tannic acid is a natural β-secretase inhibitor that prevents cognitive impairment and mitigates Alzheimer-like pathology in transgenic mice}},
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  pmid    = {22219198},
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@article{lee2012-22130662,
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@article{murakami2011-22072713,
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  title   = {{SOD1 (copper/zinc superoxide dismutase) deficiency drives amyloid β protein oligomerization and memory loss in mouse model of Alzheimer disease}},
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  title   = {{Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden}},
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  year    = {2010},
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  title   = {{Chaperone-mediated autophagy markers in Parkinson disease brains}},
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  year    = {2010},
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@article{ash2010-20530643,
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@article{tresse2010-20104022,
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  title   = {{VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD}},
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@article{freibaum2010-20020773,
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  year    = {2010},
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@article{sephton2010-20040602,
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  year    = {2010},
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  title   = {{Transactive response DNA-binding protein 43 burden in familial Alzheimer disease and Down syndrome}},
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@article{butterfield2010-19854267,
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  title   = {{In vivo oxidative stress in brain of Alzheimer disease transgenic mice: Requirement for methionine 35 in amyloid beta-peptide of APP}},
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  year    = {2010},
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@article{churchill2009-19743454,
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  title   = {{Extensive astrocyte infection is prominent in human immunodeficiency virus-associated dementia}},
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  year    = {2009},
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@article{zensi2009-19285109,
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  title   = {{Albumin nanoparticles targeted with Apo E enter the CNS by transcytosis and are delivered to neurones}},
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  year    = {2009},
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@article{seno2009-19109436,
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  title   = {{Efficient colonic mucosal wound repair requires Trem2 signaling}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2009},
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@article{mcdonald2008-18946001,
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  title   = {{Diffusion tensor imaging correlates of memory and language impairments in temporal lobe epilepsy}},
  journal = {Neurology},
  year    = {2008},
  doi     = {10.1212/01.wnl.0000327824.05348.3b},
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@article{page2008-17962197,
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  title   = {{Generation of Abeta38 and Abeta42 is independently and differentially affected by familial Alzheimer disease-associated presenilin mutations and gamma-secretase modulation}},
  journal = {The Journal of biological chemistry},
  year    = {2008},
  doi     = {10.1074/jbc.m708754200},
  pmid    = {17962197},
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@article{cao2007-17942401,
  author  = {Cao, D. and Lu, H. and Lewis, T. L. and Li, L.},
  title   = {{Intake of sucrose-sweetened water induces insulin resistance and exacerbates memory deficits and amyloidosis in a transgenic mouse model of Alzheimer disease}},
  journal = {The Journal of biological chemistry},
  year    = {2007},
  doi     = {10.1074/jbc.m703561200},
  pmid    = {17942401},
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}

@article{segers2007-17875967,
  author  = {Segers, V. F. and Tokunou, T. and Higgins, L. J. and MacGillivray, C. and Gannon, J. and Lee, R. T.},
  title   = {{Local delivery of protease-resistant stromal cell derived factor-1 for stem cell recruitment after myocardial infarction}},
  journal = {Circulation},
  year    = {2007},
  doi     = {10.1161/circulationaha.107.718718},
  pmid    = {17875967},
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}

@article{ostrowski2007-17646164,
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  title   = {{Statins reduce amyloid-beta production through inhibition of protein isoprenylation}},
  journal = {The Journal of biological chemistry},
  year    = {2007},
  doi     = {10.1074/jbc.m702640200},
  pmid    = {17646164},
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}

@article{vingtdeux2007-17468104,
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  title   = {{Alkalizing drugs induce accumulation of amyloid precursor protein by-products in luminal vesicles of multivesicular bodies}},
  journal = {The Journal of biological chemistry},
  year    = {2007},
  doi     = {10.1074/jbc.m609475200},
  pmid    = {17468104},
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@article{green2007-17442823,
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  title   = {{Dietary docosahexaenoic acid and docosapentaenoic acid ameliorate amyloid-beta and tau pathology via a mechanism involving presenilin 1 levels}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2007},
  doi     = {10.1523/jneurosci.0055-07.2007},
  pmid    = {17442823},
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}

@article{ohara2007-17353910,
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  title   = {{Serotonin transporter polymorphism, memory and hippocampal volume in the elderly: association and interaction with cortisol}},
  journal = {Molecular psychiatry},
  year    = {2007},
  doi     = {10.1038/sj.mp.4001978},
  pmid    = {17353910},
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@article{farkas2007-17296232,
  author  = {Farkas, E. and Luiten, P. G. and Bari, F.},
  title   = {{Permanent, bilateral common carotid artery occlusion in the rat: a model for chronic cerebral hypoperfusion-related neurodegenerative diseases}},
  journal = {Brain research reviews},
  year    = {2007},
  doi     = {10.1016/j.brainresrev.2007.01.003},
  pmid    = {17296232},
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}

@article{ramsey2007-17204939,
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  title   = {{Expression of Nrf2 in neurodegenerative diseases}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2007},
  doi     = {10.1097/nen.0b013e31802d6da9},
  pmid    = {17204939},
  url     = {https://doi.org/10.1097/nen.0b013e31802d6da9}
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@article{dheen2007-17504139,
  author  = {Dheen, S. T. and Kaur, C. and Ling, E. A.},
  title   = {{Microglial activation and its implications in the brain diseases}},
  journal = {Current medicinal chemistry},
  year    = {2007},
  doi     = {10.2174/092986707780597961},
  pmid    = {17504139},
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}

@article{rubia2006-16683265,
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  title   = {{Progressive increase of frontostriatal brain activation from childhood to adulthood during event-related tasks of cognitive control}},
  journal = {Human brain mapping},
  year    = {2006},
  doi     = {10.1002/hbm.20237},
  pmid    = {16683265},
  url     = {https://doi.org/10.1002/hbm.20237}
}

@article{peskind2006-16831961,
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  title   = {{Age and apolipoprotein E*4 allele effects on cerebrospinal fluid beta-amyloid 42 in adults with normal cognition}},
  journal = {Archives of neurology},
  year    = {2006},
  doi     = {10.1001/archneur.63.7.936},
  pmid    = {16831961},
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@article{obregon2006-16624814,
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  title   = {{ADAM10 activation is required for green tea (-)-epigallocatechin-3-gallate-induced alpha-secretase cleavage of amyloid precursor protein}},
  journal = {The Journal of biological chemistry},
  year    = {2006},
  doi     = {10.1074/jbc.m600617200},
  pmid    = {16624814},
  url     = {https://doi.org/10.1074/jbc.m600617200}
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@article{grudzien2007-16574280,
  author  = {Grudzien, A. and Shaw, P. and Weintraub, S. and Bigio, E. and Mash, D. C. and Mesulam, M. M.},
  title   = {{Locus coeruleus neurofibrillary degeneration in aging, mild cognitive impairment and early Alzheimer's disease}},
  journal = {Neurobiology of aging},
  year    = {2007},
  doi     = {10.1016/j.neurobiolaging.2006.02.007},
  pmid    = {16574280},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2006.02.007}
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@article{ginsberg2006-16539663,
  author  = {Ginsberg, S. D. and Che, S. and Wuu, J. and Counts, S. E. and Mufson, E. J.},
  title   = {{Down regulation of trk but not p75NTR gene expression in single cholinergic basal forebrain neurons mark the progression of Alzheimer's disease}},
  journal = {Journal of neurochemistry},
  year    = {2006},
  doi     = {10.1111/j.1471-4159.2006.03764.x},
  pmid    = {16539663},
  url     = {https://doi.org/10.1111/j.1471-4159.2006.03764.x}
}

@article{bokde2006-16520329,
  author  = {Bokde, A. L. and Lopez-Bayo, P. and Meindl, T. and Pechler, S. and Born, C. and Faltraco, F. and Teipel, S. J. and Möller, H. J. and others},
  title   = {{Functional connectivity of the fusiform gyrus during a face-matching task in subjects with mild cognitive impairment}},
  journal = {Brain : a journal of neurology},
  year    = {2006},
  doi     = {10.1093/brain/awl051},
  pmid    = {16520329},
  url     = {https://doi.org/10.1093/brain/awl051}
}

@article{castillo2006-16476807,
  author  = {Castillo, P. and Woodruff, B. and Caselli, R. and Vernino, S. and Lucchinetti, C. and Swanson, J. and Noseworthy, J. and Aksamit, A. and others},
  title   = {{Steroid-responsive encephalopathy associated with autoimmune thyroiditis}},
  journal = {Archives of neurology},
  year    = {2006},
  doi     = {10.1001/archneur.63.2.197},
  pmid    = {16476807},
  url     = {https://doi.org/10.1001/archneur.63.2.197}
}

@article{heneka2006-16452658,
  author  = {Heneka, M. T. and Ramanathan, M. and Jacobs, A. H. and Dumitrescu-Ozimek, L. and Bilkei-Gorzo, A. and Debeir, T. and Sastre, M. and Galldiks, N. and others},
  title   = {{Locus ceruleus degeneration promotes Alzheimer pathogenesis in amyloid precursor protein 23 transgenic mice}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2006},
  doi     = {10.1523/jneurosci.4236-05.2006},
  pmid    = {16452658},
  url     = {https://doi.org/10.1523/jneurosci.4236-05.2006}
}

@article{wright2006-16501663,
  author  = {Wright, C. B. and Sacco, R. L. and Rundek, T. and Delman, J. and Rabbani, L. and Elkind, M.},
  title   = {{Interleukin-6 is associated with cognitive function: the Northern Manhattan Study}},
  journal = {Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association},
  year    = {2006},
  doi     = {10.1016/j.jstrokecerebrovasdis.2005.08.009},
  pmid    = {16501663},
  url     = {https://doi.org/10.1016/j.jstrokecerebrovasdis.2005.08.009}
}

@article{vetrivel2006-16432149,
  author  = {Vetrivel, K. S. and Thinakaran, G.},
  title   = {{Amyloidogenic processing of beta-amyloid precursor protein in intracellular compartments}},
  journal = {Neurology},
  year    = {2006},
  doi     = {10.1212/01.wnl.0000192107.17175.39},
  pmid    = {16432149},
  url     = {https://doi.org/10.1212/01.wnl.0000192107.17175.39}
}

@article{eugenin2006-16436595,
  author  = {Eugenin, E. A. and Osiecki, K. and Lopez, L. and Goldstein, H. and Calderon, T. M. and Berman, J. W.},
  title   = {{CCL2/monocyte chemoattractant protein-1 mediates enhanced transmigration of human immunodeficiency virus (HIV)-infected leukocytes across the blood-brain barrier: a potential mechanism of HIV-CNS invasion and NeuroAIDS}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2006},
  doi     = {10.1523/jneurosci.3863-05.2006},
  pmid    = {16436595},
  url     = {https://doi.org/10.1523/jneurosci.3863-05.2006}
}

@article{muir2006-16359918,
  author  = {Muir, K. W.},
  title   = {{Glutamate-based therapeutic approaches: clinical trials with NMDA antagonists}},
  journal = {Current opinion in pharmacology},
  year    = {2006},
  doi     = {10.1016/j.coph.2005.12.002},
  pmid    = {16359918},
  url     = {https://doi.org/10.1016/j.coph.2005.12.002}
}

@article{chen2006-16339765,
  author  = {Chen, K. and Iribarren, P. and Hu, J. and Chen, J. and Gong, W. and Cho, E. H. and Lockett, S. and Dunlop, N. M. and others},
  title   = {{Activation of Toll-like receptor 2 on microglia promotes cell uptake of Alzheimer disease-associated amyloid beta peptide}},
  journal = {The Journal of biological chemistry},
  year    = {2006},
  doi     = {10.1074/jbc.m508125200},
  pmid    = {16339765},
  url     = {https://doi.org/10.1074/jbc.m508125200}
}

@article{koldamova2005-16207713,
  author  = {Koldamova, R. and Staufenbiel, M. and Lefterov, I.},
  title   = {{Lack of ABCA1 considerably decreases brain ApoE level and increases amyloid deposition in APP23 mice}},
  journal = {The Journal of biological chemistry},
  year    = {2005},
  doi     = {10.1074/jbc.m504513200},
  pmid    = {16207713},
  url     = {https://doi.org/10.1074/jbc.m504513200}
}

@article{vandijk2005-16061741,
  author  = {van Dijk, E. J. and Prins, N. D. and Vermeer, S. E. and Vrooman, H. A. and Hofman, A. and Koudstaal, P. J. and Breteler, M. M.},
  title   = {{C-reactive protein and cerebral small-vessel disease: the Rotterdam Scan Study}},
  journal = {Circulation},
  year    = {2005},
  doi     = {10.1161/circulationaha.104.506337},
  pmid    = {16061741},
  url     = {https://doi.org/10.1161/circulationaha.104.506337}
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@article{szeszko2005-15768049,
  author  = {Szeszko, P. R. and Lipsky, R. and Mentschel, C. and Robinson, D. and Gunduz-Bruce, H. and Sevy, S. and Ashtari, M. and Napolitano, B. and others},
  title   = {{Brain-derived neurotrophic factor val66met polymorphism and volume of the hippocampal formation}},
  journal = {Molecular psychiatry},
  year    = {2005},
  doi     = {10.1038/sj.mp.4001656},
  pmid    = {15768049},
  url     = {https://doi.org/10.1038/sj.mp.4001656}
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@article{fryer2005-15888448,
  author  = {Fryer, J. D. and Demattos, R. B. and McCormick, L. M. and O'Dell, M. A. and Spinner, M. L. and Bales, K. R. and Paul, S. M. and Sullivan, P. M. and others},
  title   = {{The low density lipoprotein receptor regulates the level of central nervous system human and murine apolipoprotein E but does not modify amyloid plaque pathology in PDAPP mice}},
  journal = {The Journal of biological chemistry},
  year    = {2005},
  doi     = {10.1074/jbc.m502143200},
  pmid    = {15888448},
  url     = {https://doi.org/10.1074/jbc.m502143200}
}

@article{mrak2005-15639313,
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  title   = {{Passive immunotherapy against Abeta in aged APP-transgenic mice reverses cognitive deficits and depletes parenchymal amyloid deposits in spite of increased vascular amyloid and microhemorrhage}},
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  title   = {{Reduction of cortical TrkA but not p75(NTR) protein in early-stage Alzheimer's disease}},
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@article{lee2026-41697144,
  author  = {Lee, Wen-Teng and Jing Tong, W. A. N. G. and Tsai, Ming‐Hsien and Fang, Yu‐Wei},
  title   = {{GLP-1 receptor agonists reduce dementia and Alzheimer disease risk in diabetic patients with CKD}},
  journal = {Nephrology Dialysis Transplantation},
  year    = {2026},
  doi     = {10.1093/ndt/gfag032},
  pmid    = {41697144},
  url     = {https://doi.org/10.1093/ndt/gfag032}
}

@article{genius2026-41561329,
  author  = {Genius, Patricia and Rodríguez‐Fernández, Blanca and Minguillón, Carolina and Anna, Brugulat-Serrat and Huguet, Jordi and Esteller, Manel and Sudre, Carole H. and Cortés‐Canteli, Marta and others},
  title   = {{Polygenic risk for white matter hyperintensities is associated with early cerebrovascular events partly through hemodynamic measures in cognitively unimpaired middle-aged and older adults with low cardiovascular risk}},
  journal = {Frontiers in Neurology},
  year    = {2026},
  doi     = {10.3389/fneur.2025.1667424},
  pmid    = {41561329},
  url     = {https://doi.org/10.3389/fneur.2025.1667424}
}

@article{kron2025-41442936,
  author  = {Kron, J and Metha, Jeremy A. and Daykin, Heather J. and Walker, Leigh C. and Potts, Yasmin and Allocca, Giancarlo and Keenan, Ryan J. and Hoyer, Daniël and others},
  title   = {{PS19 mouse tauopathy is associated with sex-dependent sleep loss and hyperarousal, and predicts cognitive performance}},
  journal = {Neurobiology of Aging},
  year    = {2025},
  doi     = {10.1016/j.neurobiolaging.2025.12.001},
  pmid    = {41442936},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2025.12.001}
}

@article{valerianolorenzo2025-ec93d4d3,
  author  = {Valeriano-Lorenzo, Elizabeth and Ricciardi, Mario Emiliano and Wagner, Sonia and Martinez, Minerva and Frades, Belén and Zea‐Sevilla, María Ascensión and Valenti, Meritxell and del Ser, Teodoro and others},
  title   = {{Modulatory effect of glial fibrillary acidic protein (GFAP) levels on the association between plasma p ‐tau217 levels and cognitive decline in older adults}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70856_106267},
  url     = {https://doi.org/10.1002/alz70856_106267}
}

@article{mattsson2025-41326715,
  author  = {Mattsson, Niklas and Karlsson, Linda and Tang, Weizhong and Blennow, Kaj and Zetterberg, Henrik and Bateman, Randall John and Schindler, Suzanne Elizabeth and Barthélemy, Nicolas R. and others},
  title   = {{Prediction of continuous amyloid positron emission tomography with fluid measures of phosphorylated tau and β-amyloid}},
  journal = {EMBO Molecular Medicine},
  year    = {2025},
  doi     = {10.1038/s44321-025-00348-7},
  pmid    = {41326715},
  url     = {https://doi.org/10.1038/s44321-025-00348-7}
}

@article{wuestefeld2025-41498671,
  author  = {Wuestefeld, Anika and Spotorno, Nicola and Binette, Alexa Pichet and Mattsson, Niklas and Ossenkoppele, Rik and Palmqvist, Sebastian and Smith, Ruben and Stomrud, Erik and others},
  title   = {{Longitudinal tau‐PET accumulation and downstream effects in amyloid‐beta negative cognitively unimpaired individuals}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70856_104826},
  pmid    = {41498671},
  url     = {https://doi.org/10.1002/alz70856_104826}
}

@article{lu2025-41277110,
  author  = {Lu, Jiayi and Di Florio, Damian Nicolas and Boya, Patricia and Maday, Sandra and Springer, Wolfdieter and Chu, Charleen T.},
  title   = {{Autophagy and mitophagy at the synapse and beyond: implications for learning, memory and neurological disorders}},
  journal = {Autophagy},
  year    = {2025},
  doi     = {10.1080/15548627.2025.2581217},
  pmid    = {41277110},
  url     = {https://doi.org/10.1080/15548627.2025.2581217}
}

@article{barnett2025-41188644,
  author  = {BARNETT, DANIEL H. and Zimmer, Till S. and Booraem, Caroline and Palaguachi, Fernando and Meadows, Samantha M. and Xiao, Haopeng and Wong, Man Ying and Luo, Wenjie and others},
  title   = {{Mitochondrial complex III-derived ROS amplify immunometabolic changes in astrocytes and promote dementia pathology}},
  journal = {Nature Metabolism},
  year    = {2025},
  doi     = {10.1038/s42255-025-01390-y},
  pmid    = {41188644},
  url     = {https://doi.org/10.1038/s42255-025-01390-y}
}

@article{vidyadhara2025-41006254,
  author  = {Vidyadhara, D. J. and Bäckström, David C. and Chakraborty, Risha and Ruan, Jiapeng and Park, Jae-Min and Mistry, Pramod Kumar and Chandra, Sreeganga S.},
  title   = {{Synaptic vesicle endocytosis deficits underlie cognitive dysfunction in mouse models of GBA-linked Parkinson’s disease and dementia with Lewy bodies}},
  journal = {Nature Communications},
  year    = {2025},
  doi     = {10.1038/s41467-025-63444-9},
  pmid    = {41006254},
  url     = {https://doi.org/10.1038/s41467-025-63444-9}
}

@article{boccalini2025-40939126,
  author  = {Boccalini, Cecilia and Mathoux, Gregory and Hristovska, Inès and Ribaldi, Federica and Peretti, Débora Elisa and Arnone, Annachiara and Scheffler, Max and Frisoni, Giovanni Battista and others},
  title   = {{Visual Classification of Tau-PET Detects 4 Subtypes With Different Long-Term Outcomes}},
  journal = {Neurology},
  year    = {2025},
  doi     = {10.1212/wnl.0000000000213950},
  pmid    = {40939126},
  url     = {https://doi.org/10.1212/wnl.0000000000213950}
}

@article{garciatoledo2025-40906043,
  author  = {García-Toledo, Irene and Godoy-Corchuelo, Juan Miguel and Fernández-Beltrán, Luis C. and Ali, Zeinab and Guindo-Arroyo, Ariadna and Jiménez-Coca, Irene and Jiménez-Rodríguez, Jesús and Javaloyes-García, Karen and others},
  title   = {{TDP-43 dysregulation impairs cholesterol metabolism linked with myelination defects}},
  journal = {Acta Neuropathologica},
  year    = {2025},
  doi     = {10.1007/s00401-025-02927-x},
  pmid    = {40906043},
  url     = {https://doi.org/10.1007/s00401-025-02927-x}
}

@article{li2025-40888555,
  author  = {Li, Yang and Wang, Jiao and Miao, Yuyang and Dunk, Michelle M. and Liu, Yan and Fang, Zhongze and Zhang, Qiang and Xu, Weili},
  title   = {{Association Between Plasma Metabolomic Profile and Machine Learning‐Based Brain Age}},
  journal = {Aging Cell},
  year    = {2025},
  doi     = {10.1111/acel.70208},
  pmid    = {40888555},
  url     = {https://doi.org/10.1111/acel.70208}
}

@article{mahulmellier2025-40858624,
  author  = {Mahul‐Mellier, Anne‐Laure and Altay, Melek Firat and Maharjan, Niran and Ait‐Bouziad, Nadine and Chiki, Anass and Jagannath, Somanath and Limorenko, Galina and Novello, Salvatore and others},
  title   = {{Differential role of C-terminal truncations on alpha-synuclein pathology and Lewy body formation}},
  journal = {npj Parkinson s Disease},
  year    = {2025},
  doi     = {10.1038/s41531-025-01084-y},
  pmid    = {40858624},
  url     = {https://doi.org/10.1038/s41531-025-01084-y}
}

@article{montoliugaya2025-40791093,
  author  = {Montoliu-Gaya, L. and Valeriano-Lorenzo, E. and Ashton, N. J. and López-González, F. J. and Lantero-Rodriguez, J. and Ruiz-González, A. and Pastor, A. B. and Frades, B. and others},
  title   = {{Plasma tau biomarkers are distinctly associated with tau tangles and decreased with Lewy body pathology}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2025},
  doi     = {10.1002/alz.70562},
  pmid    = {40791093},
  url     = {https://doi.org/10.1002/alz.70562}
}

@article{chu2025-40791104,
  author  = {Chu, Min and Yue, Ailing and Yan, Shaozhen and Yu, Boyang and He, Qianqian and Chen, Yufei and Hou, Jiahui and Nan, Haitian and others},
  title   = {{Glymphatic activity in behavioral variant frontotemporal dementia: Link with vascular function and astrocytic activation}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz.70561},
  pmid    = {40791104},
  url     = {https://doi.org/10.1002/alz.70561}
}

@article{yu2025-40840993,
  author  = {Yu, Congcong and Yang, Huijie and Zhang, Bing and Chen, Shihua and Yang, Sijue and Li, Fangyi and Zhu, Wenhui and Zhai, Beibei and others},
  title   = {{Evaluating the effects of liraglutide, empagliflozin and linagliptin on mild cognitive impairment remission in patients with type 2 diabetes (LIGHT-MCI): study protocol for a multicentre, randomised controlled trial with an extension phase}},
  journal = {BMJ Open},
  year    = {2025},
  doi     = {10.1136/bmjopen-2024-095382},
  pmid    = {40840993},
  url     = {https://doi.org/10.1136/bmjopen-2024-095382}
}

@article{che2025-40622016,
  author  = {Che, Ping and Wang, Siqi and Liu, Xiaojiao and Lu, Yunyao and Tian, Zhuo and Feng, Qixin and Chen, Feifan and Zhang, Nan},
  title   = {{Plasma placental growth factor as a biomarker for subcortical ischemic vascular dementia and its cognitive correlation mediated by white matter hyperintensities}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz.70461},
  pmid    = {40622016},
  url     = {https://doi.org/10.1002/alz.70461}
}

@article{peduzzi2025-40368260,
  author  = {Peduzzi, Giulia and Archibugi, Lívia and Farinella, Riccardo and Pisani, Ruggero Ponz de Leon and Vodičková, Ľudmila and Vodička, Pavel and Kraja, Bledar and Sáinz, Juan and others},
  title   = {{The exposome and pancreatic cancer, lifestyle and environmental risk factors for PDAC}},
  journal = {Seminars in Cancer Biology},
  year    = {2025},
  doi     = {10.1016/j.semcancer.2025.05.004},
  pmid    = {40368260},
  url     = {https://doi.org/10.1016/j.semcancer.2025.05.004}
}

@article{vizziello2025-40287755,
  author  = {Vizziello, Maria and Dellarole, Ilaria Linda and Ciullini, Arianna and Pascuzzo, Riccardo and Lombardo, Annalisa and Bellandi, Floriana and Celauro, Luigi and Battipaglia, Claudia and others},
  title   = {{TDP-43 seeding activity in the olfactory mucosa of patients with amyotrophic lateral sclerosis}},
  journal = {Molecular Neurodegeneration},
  year    = {2025},
  doi     = {10.1186/s13024-025-00833-0},
  pmid    = {40287755},
  url     = {https://doi.org/10.1186/s13024-025-00833-0}
}

@article{reheman2025-40280215,
  author  = {Reheman, Mariyemuguli and Buch, Sagar and He, Naying and Huang, Pei and Yu, Qiurong and Wang, Xinhui and Liu, Yu and Zhang, Youmin and others},
  title   = {{White matter hyperintensity tissue property spatial variations as a function of cognitive status in Parkinson’s disease}},
  journal = {NeuroImage},
  year    = {2025},
  doi     = {10.1016/j.neuroimage.2025.121236},
  pmid    = {40280215},
  url     = {https://doi.org/10.1016/j.neuroimage.2025.121236}
}

@article{du2025-40260760,
  author  = {Du, Wei and Zou, Zhen‐Ping and Ye, Bang‐Ce and Zhou, Ying Qian},
  title   = {{Gut microbiota and associated metabolites: key players in high-fat diet-induced chronic diseases}},
  journal = {Gut Microbes},
  year    = {2025},
  doi     = {10.1080/19490976.2025.2494703},
  pmid    = {40260760},
  url     = {https://doi.org/10.1080/19490976.2025.2494703}
}

@article{serpente2025-40064379,
  author  = {Serpente, María and Delvecchio, Giuseppe and Fenoglio, Chiara and Di Consoli, Lorena and De Giudici, Giovanni and Borracci, Vittoria and Rotondo, Emanuela and Arcaro, Marina and others},
  title   = {{Differential miRNA expression in neural-enriched extracellular vesicles as potential biomarker for frontotemporal dementia and bipolar disorder}},
  journal = {Neurobiology of Disease},
  year    = {2025},
  doi     = {10.1016/j.nbd.2025.106867},
  pmid    = {40064379},
  url     = {https://doi.org/10.1016/j.nbd.2025.106867}
}

@article{bosworth2025-40048429,
  author  = {Bosworth, Alexandra P and Contreras, Minerva and Sancho, Laura and Salas, Isabel H. and Paumier, Adrien and Novak, Sammy Weiser and Manor, Uri and Allen, Nicola J.},
  title   = {{Astrocyte glypican 5 regulates synapse maturation and stabilization}},
  journal = {Cell Reports},
  year    = {2025},
  doi     = {10.1016/j.celrep.2025.115374},
  pmid    = {40048429},
  url     = {https://doi.org/10.1016/j.celrep.2025.115374}
}

@article{kawazoe2025-40007723,
  author  = {Kawazoe, Miki and Koga, Shunsuke and Sekiya, Hiroaki and Josephs, Keith A. and Graff‐Radford, Neill R. and Dickson, Dennis W.},
  title   = {{Disproportionately Enlarged Subarachnoid-Space Hydrocephalus on MRI in Pathologically Confirmed Progressive Supranuclear Palsy}},
  journal = {Neurology Clinical Practice},
  year    = {2025},
  doi     = {10.1212/cpj.0000000000200431},
  pmid    = {40007723},
  url     = {https://doi.org/10.1212/cpj.0000000000200431}
}

@article{islam2025-39944166,
  author  = {Islam, Sadequl and Noorani, Arshad Ali and Sun, Yang and Michikawa, Makoto and Zou, Kun},
  title   = {{Multi-functional role of apolipoprotein E in neurodegenerative diseases}},
  journal = {Frontiers in Aging Neuroscience},
  year    = {2025},
  doi     = {10.3389/fnagi.2025.1535280},
  pmid    = {39944166},
  url     = {https://doi.org/10.3389/fnagi.2025.1535280}
}

@article{brandao2025-39813317,
  author  = {Brandão, Wesley Nogueira and Jain, Nimansha and Yin, Zhuoran and Kleemann, Kilian L. and Carpenter, Madison and Bao, Xin and Serrano, Javier Remolina and Tycksen, Eric and others},
  title   = {{Inhaled xenon modulates microglia and ameliorates disease in mouse models of amyloidosis and tauopathy}},
  journal = {Science Translational Medicine},
  year    = {2025},
  doi     = {10.1126/scitranslmed.adk3690},
  pmid    = {39813317},
  url     = {https://doi.org/10.1126/scitranslmed.adk3690}
}

@article{fremuth2025-39817909,
  author  = {Fremuth, L. E. and Hu, H. and van de Vlekkert, D. and Annunziata, I. and Weesner, J. A. and d'Azzo, Alessandra},
  title   = {{Neuraminidase 1 regulates neuropathogenesis by governing the cellular state of microglia via modulation of Trem2 sialylation}},
  journal = {Cell reports},
  year    = {2025},
  doi     = {10.1016/j.celrep.2024.115204},
  pmid    = {39817909},
  url     = {https://doi.org/10.1016/j.celrep.2024.115204}
}

@article{wang2024-38942796,
  author  = {Wang, Y. and Chen, W. and Qiao, S. and Zou, H. and Yu, X. J. and Yang, Y. and Li, Z. and Wang, J. and others},
  title   = {{Lipid droplet accumulation mediates macrophage survival and Treg recruitment via the CCL20/CCR6 axis in human hepatocellular carcinoma}},
  journal = {Cellular \& molecular immunology},
  year    = {2024},
  doi     = {10.1038/s41423-024-01199-x},
  pmid    = {38942796},
  url     = {https://doi.org/10.1038/s41423-024-01199-x}
}

@article{shi2025-38769824,
  author  = {Shi, Q. and Gutierrez, R. A. and Bhat, M. A.},
  title   = {{Microglia, Trem2, and Neurodegeneration}},
  journal = {The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry},
  year    = {2025},
  doi     = {10.1177/10738584241254118},
  pmid    = {38769824},
  url     = {https://doi.org/10.1177/10738584241254118}
}

@article{ocanas2023-37587511,
  author  = {Ocañas, SR. and Pham, K. D. and Cox, J. E. J. and Keck, A. W. and Ko, S. and Ampadu, F. A. and Porter, H. L. and Ansere, V. A. and others},
  title   = {{Microglial senescence contributes to female-biased neuroinflammation in the aging mouse hippocampus: implications for Alzheimer's disease}},
  journal = {Journal of neuroinflammation},
  year    = {2023},
  doi     = {10.1186/s12974-023-02870-2},
  pmid    = {37587511},
  url     = {https://doi.org/10.1186/s12974-023-02870-2}
}

@article{li2023-37517293,
  author  = {Li, Y. and Xu, H. and Wang, H. and Yang, K. and Luan, J. and Wang, S.},
  title   = {{TREM2: Potential therapeutic targeting of microglia for Alzheimer's disease}},
  journal = {Biomedicine \& pharmacotherapy = Biomedecine \& pharmacotherapie},
  year    = {2023},
  doi     = {10.1016/j.biopha.2023.115218},
  pmid    = {37517293},
  url     = {https://doi.org/10.1016/j.biopha.2023.115218}
}

@article{zhao2022-35717259,
  author  = {Zhao, P. and Xu, Y. and Jiang, L. L. and Fan, X. and Ku, Z. and Li, L. and Liu, X. and Deng, M. and others},
  title   = {{LILRB2-mediated TREM2 signaling inhibition suppresses microglia functions}},
  journal = {Molecular neurodegeneration},
  year    = {2022},
  doi     = {10.1186/s13024-022-00550-y},
  pmid    = {35717259},
  url     = {https://doi.org/10.1186/s13024-022-00550-y}
}

@article{zhang2022-35278107,
  author  = {Zhang, H. and Liu, Z. and Wen, H. and Guo, Y. and Xu, F. and Zhu, Q. and Yuan, W. and Luo, R. and others},
  title   = {{Immunosuppressive TREM2(+) macrophages are associated with undesirable prognosis and responses to anti-PD-1 immunotherapy in non-small cell lung cancer}},
  journal = {Cancer immunology, immunotherapy : CII},
  year    = {2022},
  doi     = {10.1007/s00262-022-03173-w},
  pmid    = {35278107},
  url     = {https://doi.org/10.1007/s00262-022-03173-w}
}

@article{zhang2022-35123512,
  author  = {Zhang, S. S. and Zhu, L. and Peng, Y. and Zhang, L. and Chao, F. L. and Jiang, L. and Xiao, Q. and Liang, X. and others},
  title   = {{Long-term running exercise improves cognitive function and promotes microglial glucose metabolism and morphological plasticity in the hippocampus of APP/PS1 mice}},
  journal = {Journal of neuroinflammation},
  year    = {2022},
  doi     = {10.1186/s12974-022-02401-5},
  pmid    = {35123512},
  url     = {https://doi.org/10.1186/s12974-022-02401-5}
}

@article{rhinn2022-35039149,
  author  = {Rhinn, H. and Tatton, N. and McCaughey, S. and Kurnellas, M. and Rosenthal, A.},
  title   = {{Progranulin as a therapeutic target in neurodegenerative diseases}},
  journal = {Trends in pharmacological sciences},
  year    = {2022},
  doi     = {10.1016/j.tips.2021.11.015},
  pmid    = {35039149},
  url     = {https://doi.org/10.1016/j.tips.2021.11.015}
}

@article{picard2021-34343616,
  author  = {Picard, K. and Bisht, K. and Poggini, S. and Garofalo, S. and Golia, M. T. and Basilico, B. and Abdallah, F. and Ciano Albanese, N. and others},
  title   = {{Microglial-glucocorticoid receptor depletion alters the response of hippocampal microglia and neurons in a chronic unpredictable mild stress paradigm in female mice}},
  journal = {Brain, behavior, and immunity},
  year    = {2021},
  doi     = {10.1016/j.bbi.2021.07.022},
  pmid    = {34343616},
  url     = {https://doi.org/10.1016/j.bbi.2021.07.022}
}

@article{lleo2021-34183050,
  author  = {Lleó, A. and Carmona-Iragui, M. and Videla, L. and Fernández, S. and Benejam, B. and Pegueroles, J. and Barroeta, I. and Altuna, M. and others},
  title   = {{VAMP-2 is a surrogate cerebrospinal fluid marker of Alzheimer-related cognitive impairment in adults with Down syndrome}},
  journal = {Alzheimer's research \& therapy},
  year    = {2021},
  doi     = {10.1186/s13195-021-00861-0},
  pmid    = {34183050},
  url     = {https://doi.org/10.1186/s13195-021-00861-0}
}

@article{root2021-33812000,
  author  = {Root, J. and Merino, P. and Nuckols, A. and Johnson, M. and Kukar, T.},
  title   = {{Lysosome dysfunction as a cause of neurodegenerative diseases: Lessons from frontotemporal dementia and amyotrophic lateral sclerosis}},
  journal = {Neurobiology of disease},
  year    = {2021},
  doi     = {10.1016/j.nbd.2021.105360},
  pmid    = {33812000},
  url     = {https://doi.org/10.1016/j.nbd.2021.105360}
}

@article{butt2021-33765432,
  author  = {Butt, O. H. and Long, J. M. and Henson, R. L. and Herries, E. and Sutphen, C. L. and Fagan, A. M. and Cruchaga, C. and Ladenson, J. H. and others},
  title   = {{Cognitively normal APOE ε4 carriers have specific elevation of CSF SNAP-25}},
  journal = {Neurobiology of aging},
  year    = {2021},
  doi     = {10.1016/j.neurobiolaging.2021.02.008},
  pmid    = {33765432},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2021.02.008}
}

@article{bordeleau2020-32891154,
  author  = {Bordeleau, M. and Lacabanne, C. and Fernández de Cossío, L. and Vernoux, N. and Savage, J. C. and González-Ibáñez, F. and MÈ, Tremblay},
  title   = {{Microglial and peripheral immune priming is partially sexually dimorphic in adolescent mouse offspring exposed to maternal high-fat diet}},
  journal = {Journal of neuroinflammation},
  year    = {2020},
  doi     = {10.1186/s12974-020-01914-1},
  pmid    = {32891154},
  url     = {https://doi.org/10.1186/s12974-020-01914-1}
}

@article{brinn2020-32690528,
  author  = {Brinn, A. and Stone, J.},
  title   = {{Neutrophil-lymphocyte ratio across psychiatric diagnoses: a cross-sectional study using electronic health records}},
  journal = {BMJ open},
  year    = {2020},
  doi     = {10.1136/bmjopen-2020-036859},
  pmid    = {32690528},
  url     = {https://doi.org/10.1136/bmjopen-2020-036859}
}

@article{hammes2021-32620704,
  author  = {Hammes, J. and Bischof, G. N. and Bohn, K. P. and Ö, Onur and Schneider, A. and Fliessbach, K. and Hönig, M. C. and Jessen, F. and others},
  title   = {{One-Stop Shop: 18F-Flortaucipir PET Differentiates Amyloid-Positive and -Negative Forms of Neurodegenerative Diseases}},
  journal = {Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year    = {2021},
  doi     = {10.2967/jnumed.120.244061},
  pmid    = {32620704},
  url     = {https://doi.org/10.2967/jnumed.120.244061}
}

@article{puigdellivol2020-32581723,
  author  = {Puigdellívol, M. and Allendorf, D. H. and Brown, G. C.},
  title   = {{Sialylation and Galectin-3 in Microglia-Mediated Neuroinflammation and Neurodegeneration}},
  journal = {Frontiers in cellular neuroscience},
  year    = {2020},
  doi     = {10.3389/fncel.2020.00162},
  pmid    = {32581723},
  url     = {https://doi.org/10.3389/fncel.2020.00162}
}

@article{muller2020-32326586,
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  year    = {2020},
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}

@article{muddapu2020-32296300,
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  title   = {{Neurodegenerative Diseases - Is Metabolic Deficiency the Root Cause?}},
  journal = {Frontiers in neuroscience},
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@article{mcsweeney2020-32015176,
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  title   = {{Intermediate flortaucipir uptake is associated with Aβ-PET and CSF tau in asymptomatic adults}},
  journal = {Neurology},
  year    = {2020},
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  pmid    = {32015176},
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@article{yao2019-31649511,
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  title   = {{Distinct Signaling Pathways Regulate TREM2 Phagocytic and NFκB Antagonistic Activities}},
  journal = {Frontiers in cellular neuroscience},
  year    = {2019},
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@article{bohlen2019-31518519,
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  title   = {{Microglia in Brain Development, Homeostasis, and Neurodegeneration}},
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  year    = {2019},
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  pmid    = {31518519},
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@article{mezzaroba2019-31377220,
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  title   = {{The role of zinc, copper, manganese and iron in neurodegenerative diseases}},
  journal = {Neurotoxicology},
  year    = {2019},
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@article{baburamani2019-31102269,
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  title   = {{New approaches to studying early brain development in Down syndrome}},
  journal = {Developmental medicine and child neurology},
  year    = {2019},
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@article{taghdiri2019-31068482,
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  title   = {{Elevated cerebrospinal fluid total tau in former professional athletes with multiple concussions}},
  journal = {Neurology},
  year    = {2019},
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  pmid    = {31068482},
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@article{song2019-31033233,
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  title   = {{Dissecting intratumoral myeloid cell plasticity by single cell RNA-seq}},
  journal = {Cancer medicine},
  year    = {2019},
  doi     = {10.1002/cam4.2113},
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@article{shinomoto2019-30951523,
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  title   = {{Plasma neurofilament light chain: A potential prognostic biomarker of dementia in adult Down syndrome patients}},
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  pmid    = {30951523},
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@article{schubert2019-30850505,
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  title   = {{Dynamic 11C-PiB PET Shows Cerebrospinal Fluid Flow Alterations in Alzheimer Disease and Multiple Sclerosis}},
  journal = {Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year    = {2019},
  doi     = {10.2967/jnumed.118.223834},
  pmid    = {30850505},
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@article{claes2019-30442540,
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  title   = {{Human stem cell-derived monocytes and microglia-like cells reveal impaired amyloid plaque clearance upon heterozygous or homozygous loss of TREM2}},
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  year    = {2019},
  doi     = {10.1016/j.jalz.2018.09.006},
  pmid    = {30442540},
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@article{zhou2018-30038567,
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  title   = {{TREM2-Dependent Effects on Microglia in Alzheimer's Disease}},
  journal = {Frontiers in aging neuroscience},
  year    = {2018},
  doi     = {10.3389/fnagi.2018.00202},
  pmid    = {30038567},
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@article{sudom2018-29794134,
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  title   = {{Molecular basis for the loss-of-function effects of the Alzheimer's disease-associated R47H variant of the immune receptor TREM2}},
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  year    = {2018},
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  pmid    = {29794134},
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@article{bekris2018-29685286,
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  title   = {{Soluble TREM2 and biomarkers of central and peripheral inflammation in neurodegenerative disease}},
  journal = {Journal of neuroimmunology},
  year    = {2018},
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  pmid    = {29685286},
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@article{li2018-29511089,
  author  = {Li, H. R. and Chiang, W. C. and Chou, P. C. and Wang, W. J. and Huang, JR.},
  title   = {{TAR DNA-binding protein 43 (TDP-43) liquid-liquid phase separation is mediated by just a few aromatic residues}},
  journal = {The Journal of biological chemistry},
  year    = {2018},
  doi     = {10.1074/jbc.ac117.001037},
  pmid    = {29511089},
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@article{cui2018-28970251,
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  title   = {{Exosomes derived from hypoxia-preconditioned mesenchymal stromal cells ameliorate cognitive decline by rescuing synaptic dysfunction and regulating inflammatory responses in APP/PS1 mice}},
  journal = {FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year    = {2018},
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@article{nelson2018-29186501,
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  title   = {{The Amygdala as a Locus of Pathologic Misfolding in Neurodegenerative Diseases}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2018},
  doi     = {10.1093/jnen/nlx099},
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@article{umoh2018-29191947,
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  title   = {{A proteomic network approach across the ALS-FTD disease spectrum resolves clinical phenotypes and genetic vulnerability in human brain}},
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@article{devous2018-29284675,
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  title   = {{Test-Retest Reproducibility for the Tau PET Imaging Agent Flortaucipir F 18}},
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@article{condello2018-29169609,
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  title   = {{Microglia-Mediated Neuroprotection, TREM2, and Alzheimer's Disease: Evidence From Optical Imaging}},
  journal = {Biological psychiatry},
  year    = {2018},
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@article{parcon2018-28945989,
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  title   = {{Apolipoprotein E4 inhibits autophagy gene products through direct, specific binding to CLEAR motifs}},
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  year    = {2018},
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@article{kim2017-28894284,
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  title   = {{TREM2 promotes Aβ phagocytosis by upregulating C/EBPα-dependent CD36 expression in microglia}},
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@article{faraco2017-28782084,
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  year    = {2017},
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@article{nam2017-28655926,
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  title   = {{Effect of high fat diet on phenotype, brain transcriptome and lipidome in Alzheimer's model mice}},
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@article{wu2017-28592261,
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@article{garciaayllon2017-28559572,
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  title   = {{C-terminal fragments of the amyloid precursor protein in cerebrospinal fluid as potential biomarkers for Alzheimer disease}},
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@article{dardiotis2017-28214109,
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  title   = {{A novel mutation in TREM2 gene causing Nasu-Hakola disease and review of the literature}},
  journal = {Neurobiology of aging},
  year    = {2017},
  doi     = {10.1016/j.neurobiolaging.2017.01.015},
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  title   = {{Glial Activation and Glucose Metabolism in a Transgenic Amyloid Mouse Model: A Triple-Tracer PET Study}},
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  year    = {2016},
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@article{cox2016-26791617,
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@article{catorce2016-26639457,
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@article{schnoder2016-26663083,
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  title   = {{Deficiency of Neuronal p38α MAPK Attenuates Amyloid Pathology in Alzheimer Disease Mouse and Cell Models through Facilitating Lysosomal Degradation of BACE1}},
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  year    = {2016},
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@article{gui2015-26497684,
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@article{saftig2015-26522965,
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@article{buratti2015-26410029,
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  year    = {2015},
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@article{egea2015-26232730,
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@article{kostylev2015-26018073,
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  title   = {{Prion-Protein-interacting Amyloid-β Oligomers of High Molecular Weight Are Tightly Correlated with Memory Impairment in Multiple Alzheimer Mouse Models}},
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  year    = {2015},
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  title   = {{Hydration water mobility is enhanced around tau amyloid fibers}},
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@article{swinnen2014-25311585,
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@article{politis2015-25086269,
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  title   = {{Autophagy in microglia degrades extracellular β-amyloid fibrils and regulates the NLRP3 inflammasome}},
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@article{blurtonjones2014-25022790,
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  title   = {{Neural stem cells genetically-modified to express neprilysin reduce pathology in Alzheimer transgenic models}},
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@article{gutierrez2013-23557952,
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  title   = {{Perivascular spaces are associated with atherosclerosis: an insight from the Northern Manhattan Study}},
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@article{bluher2013-23731879,
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@article{rushworth2013-23386614,
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  year    = {2013},
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  title   = {{SOD1 in cerebral spinal fluid as a pharmacodynamic marker for antisense oligonucleotide therapy}},
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  title   = {{Inhibition of glycogen synthase kinase-3 ameliorates β-amyloid pathology and restores lysosomal acidification and mammalian target of rapamycin activity in the Alzheimer disease mouse model: in vivo and in vitro studies}},
  journal = {The Journal of biological chemistry},
  year    = {2013},
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  title   = {{Disrupted topological organization in white matter structural networks in amnestic mild cognitive impairment: relationship to subtype}},
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  title   = {{δ-Catenin is genetically and biologically associated with cortical cataract and future Alzheimer-related structural and functional brain changes}},
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  title   = {{Targeted delivery of nerve growth factor via encapsulated cell biodelivery in Alzheimer disease: a technology platform for restorative neurosurgery}},
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  year    = {2012},
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@article{seibert2012-22371611,
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  title   = {{Interregional correlations in Parkinson disease and Parkinson-related dementia with resting functional MR imaging}},
  journal = {Radiology},
  year    = {2012},
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@article{choi2012-22354138,
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  title   = {{Correlation of amyloid PET ligand florbetapir F 18 binding with Aβ aggregation and neuritic plaque deposition in postmortem brain tissue}},
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  year    = {2012},
  doi     = {10.1097/wad.0b013e31821300bc},
  pmid    = {22354138},
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@article{perluigi2012-22203843,
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  year    = {2012},
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@article{ito2011-21956652,
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  title   = {{TREM‐2, triggering receptor expressed on myeloid cell‐2, negatively regulates TLR responses in dendritic cells}},
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  year    = {2011},
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@article{vana2011-21945902,
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  title   = {{Progression of tau pathology in cholinergic Basal forebrain neurons in mild cognitive impairment and Alzheimer's disease}},
  journal = {The American journal of pathology},
  year    = {2011},
  doi     = {10.1016/j.ajpath.2011.07.044},
  pmid    = {21945902},
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@article{jimenez2011-21460223,
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  title   = {{Age-dependent accumulation of soluble amyloid beta (Abeta) oligomers reverses the neuroprotective effect of soluble amyloid precursor protein-alpha (sAPP(alpha)) by modulating phosphatidylinositol 3-kinase (PI3K)/Akt-GSK-3beta pathway in Alzheimer mouse model}},
  journal = {The Journal of biological chemistry},
  year    = {2011},
  doi     = {10.1074/jbc.m110.209718},
  pmid    = {21460223},
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@article{grimm2011-21324907,
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  title   = {{Docosahexaenoic acid reduces amyloid beta production via multiple pleiotropic mechanisms}},
  journal = {The Journal of biological chemistry},
  year    = {2011},
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  pmid    = {21324907},
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@article{brown2011-20946471,
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  title   = {{Review: cerebral microvascular pathology in ageing and neurodegeneration}},
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  year    = {2011},
  doi     = {10.1111/j.1365-2990.2010.01139.x},
  pmid    = {20946471},
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@article{pabon2011-21266082,
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  title   = {{CX3CL1 reduces neurotoxicity and microglial activation in a rat model of Parkinson's disease}},
  journal = {Journal of neuroinflammation},
  year    = {2011},
  doi     = {10.1186/1742-2094-8-9},
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@article{austin2010-21127294,
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  title   = {{Endothelial nitric oxide modulates expression and processing of amyloid precursor protein}},
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  year    = {2010},
  doi     = {10.1161/circresaha.110.233080},
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@article{donkin2010-20739291,
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  title   = {{ATP-binding cassette transporter A1 mediates the beneficial effects of the liver X receptor agonist GW3965 on object recognition memory and amyloid burden in amyloid precursor protein/presenilin 1 mice}},
  journal = {The Journal of biological chemistry},
  year    = {2010},
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  pmid    = {20739291},
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@article{josephs2010-20457960,
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  title   = {{Fluorodeoxyglucose F18 positron emission tomography in progressive apraxia of speech and primary progressive aphasia variants}},
  journal = {Archives of neurology},
  year    = {2010},
  doi     = {10.1001/archneurol.2010.78},
  pmid    = {20457960},
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@article{mori2010-19705461,
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  title   = {{Overexpression of human S100B exacerbates cerebral amyloidosis and gliosis in the Tg2576 mouse model of Alzheimer's disease}},
  journal = {Glia},
  year    = {2010},
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  pmid    = {19705461},
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@article{weintraub2009-19700669,
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  title   = {{The northwestern anagram test: measuring sentence production in primary progressive aphasia}},
  journal = {American journal of Alzheimer's disease and other dementias},
  year    = {2009},
  doi     = {10.1177/1533317509343104},
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@article{tolboom2009-19690025,
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  title   = {{Relationship of cerebrospinal fluid markers to 11C-PiB and 18F-FDDNP binding}},
  journal = {Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year    = {2009},
  doi     = {10.2967/jnumed.109.064360},
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@article{rankin2009-19501175,
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  title   = {{Detecting sarcasm from paralinguistic cues: anatomic and cognitive correlates in neurodegenerative disease}},
  journal = {NeuroImage},
  year    = {2009},
  doi     = {10.1016/j.neuroimage.2009.05.077},
  pmid    = {19501175},
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@article{stefano2009-19457124,
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  title   = {{The surface-exposed chaperone, Hsp60, is an agonist of the microglial TREM2 receptor}},
  journal = {Journal of neurochemistry},
  year    = {2009},
  doi     = {10.1111/j.1471-4159.2009.06130.x},
  pmid    = {19457124},
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}

@article{sanz2009-19299738,
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  title   = {{Activation of microglia by amyloid beta requires P2X7 receptor expression}},
  journal = {Journal of immunology (Baltimore, Md. : 1950)},
  year    = {2009},
  doi     = {10.4049/jimmunol.0803612},
  pmid    = {19299738},
  url     = {https://doi.org/10.4049/jimmunol.0803612}
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@article{hoe2009-19164281,
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  title   = {{The effects of amyloid precursor protein on postsynaptic composition and activity}},
  journal = {The Journal of biological chemistry},
  year    = {2009},
  doi     = {10.1074/jbc.m900141200},
  pmid    = {19164281},
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@article{lourenco2009-19148186,
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  title   = {{Netrin-1 interacts with amyloid precursor protein and regulates amyloid-beta production}},
  journal = {Cell death and differentiation},
  year    = {2009},
  doi     = {10.1038/cdd.2008.191},
  pmid    = {19148186},
  url     = {https://doi.org/10.1038/cdd.2008.191}
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@article{josephs2008-18989114,
  author  = {Josephs, K. A. and Duffy, JR.},
  title   = {{Apraxia of speech and nonfluent aphasia: a new clinical marker for corticobasal degeneration and progressive supranuclear palsy}},
  journal = {Current opinion in neurology},
  year    = {2008},
  doi     = {10.1097/wco.0b013e3283168ddd},
  pmid    = {18989114},
  url     = {https://doi.org/10.1097/wco.0b013e3283168ddd}
}

@article{shi2008-18658135,
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  title   = {{Increased dosage of Dyrk1A alters alternative splicing factor (ASF)-regulated alternative splicing of tau in Down syndrome}},
  journal = {The Journal of biological chemistry},
  year    = {2008},
  doi     = {10.1074/jbc.m802645200},
  pmid    = {18658135},
  url     = {https://doi.org/10.1074/jbc.m802645200}
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@article{cole2008-18650431,
  author  = {Cole, S. L. and Vassar, R.},
  title   = {{The role of amyloid precursor protein processing by BACE1, the beta-secretase, in Alzheimer disease pathophysiology}},
  journal = {The Journal of biological chemistry},
  year    = {2008},
  doi     = {10.1074/jbc.r800015200},
  pmid    = {18650431},
  url     = {https://doi.org/10.1074/jbc.r800015200}
}

@article{im2008-18691657,
  author  = {Im, K. and Lee, J. M. and Seo, S. W. and Hyung Kim, S. and Kim, S. I. and Na, D. L.},
  title   = {{Sulcal morphology changes and their relationship with cortical thickness and gyral white matter volume in mild cognitive impairment and Alzheimer's disease}},
  journal = {NeuroImage},
  year    = {2008},
  doi     = {10.1016/j.neuroimage.2008.07.016},
  pmid    = {18691657},
  url     = {https://doi.org/10.1016/j.neuroimage.2008.07.016}
}

@article{liu2008-18509201,
  author  = {Liu, F. and Liang, Z. and Wegiel, J. and Hwang, Y. W. and Iqbal, K. and Grundke-Iqbal, I. and Ramakrishna, N. and Gong, C. X.},
  title   = {{Overexpression of Dyrk1A contributes to neurofibrillary degeneration in Down syndrome}},
  journal = {FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year    = {2008},
  doi     = {10.1096/fj.07-104539},
  pmid    = {18509201},
  url     = {https://doi.org/10.1096/fj.07-104539}
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@article{lee2008-18276590,
  author  = {Lee, J. and Retamal, C. and Cuitiño, L. and Caruano-Yzermans, A. and Shin, J. E. and van Kerkhof, P. and Marzolo, M. P. and Bu, G.},
  title   = {{Adaptor protein sorting nexin 17 regulates amyloid precursor protein trafficking and processing in the early endosomes}},
  journal = {The Journal of biological chemistry},
  year    = {2008},
  doi     = {10.1074/jbc.m800642200},
  pmid    = {18276590},
  url     = {https://doi.org/10.1074/jbc.m800642200}
}

@article{buggiaprevot2008-18263584,
  author  = {Buggia-Prevot, V. and Sevalle, J. and Rossner, S. and Checler, F.},
  title   = {{NFkappaB-dependent control of BACE1 promoter transactivation by Abeta42}},
  journal = {The Journal of biological chemistry},
  year    = {2008},
  doi     = {10.1074/jbc.m706579200},
  pmid    = {18263584},
  url     = {https://doi.org/10.1074/jbc.m706579200}
}

@article{reed2008-18325775,
  author  = {Reed, T. and Perluigi, M. and Sultana, R. and Pierce, W. M. and Klein, J. B. and Turner, D. M. and Coccia, R. and Markesbery, W. R. and others},
  title   = {{Redox proteomic identification of 4-hydroxy-2-nonenal-modified brain proteins in amnestic mild cognitive impairment: insight into the role of lipid peroxidation in the progression and pathogenesis of Alzheimer's disease}},
  journal = {Neurobiology of disease},
  year    = {2008},
  doi     = {10.1016/j.nbd.2007.12.007},
  pmid    = {18325775},
  url     = {https://doi.org/10.1016/j.nbd.2007.12.007}
}

@article{wakabayashi2007-18018486,
  author  = {Wakabayashi, K. and Tanji, K. and Mori, F. and Takahashi, H.},
  title   = {{The Lewy body in Parkinson's disease: molecules implicated in the formation and degradation of alpha-synuclein aggregates}},
  journal = {Neuropathology : official journal of the Japanese Society of Neuropathology},
  year    = {2007},
  doi     = {10.1111/j.1440-1789.2007.00803.x},
  pmid    = {18018486},
  url     = {https://doi.org/10.1111/j.1440-1789.2007.00803.x}
}

@article{ryoo2007-17906291,
  author  = {Ryoo, SR. and Jeong, H. K. and Radnaabazar, C. and Yoo, J. J. and Cho, H. J. and Lee, H. W. and Kim, I. S. and Cheon, Y. H. and others},
  title   = {{DYRK1A-mediated hyperphosphorylation of Tau. A functional link between Down syndrome and Alzheimer disease}},
  journal = {The Journal of biological chemistry},
  year    = {2007},
  doi     = {10.1074/jbc.m707358200},
  pmid    = {17906291},
  url     = {https://doi.org/10.1074/jbc.m707358200}
}

@article{hasegawa2007-17439983,
  author  = {Hasegawa, M. and Arai, T. and Akiyama, H. and Nonaka, T. and Mori, H. and Hashimoto, T. and Yamazaki, M. and Oyanagi, K.},
  title   = {{TDP-43 is deposited in the Guam parkinsonism-dementia complex brains}},
  journal = {Brain : a journal of neurology},
  year    = {2007},
  doi     = {10.1093/brain/awm065},
  pmid    = {17439983},
  url     = {https://doi.org/10.1093/brain/awm065}
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@article{majumdar2007-17314396,
  author  = {Majumdar, A. and Cruz, D. and Asamoah, N. and Buxbaum, A. and Sohar, I. and Lobel, P. and Maxfield, F. R.},
  title   = {{Activation of microglia acidifies lysosomes and leads to degradation of Alzheimer amyloid fibrils}},
  journal = {Molecular biology of the cell},
  year    = {2007},
  doi     = {10.1091/mbc.e06-10-0975},
  pmid    = {17314396},
  url     = {https://doi.org/10.1091/mbc.e06-10-0975}
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@article{colton2006-17005052,
  author  = {Colton, C. A. and Mott, R. T. and Sharpe, H. and Xu, Q. and Van Nostrand, W. E. and Vitek, M. P.},
  title   = {{Expression profiles for macrophage alternative activation genes in AD and in mouse models of AD}},
  journal = {Journal of neuroinflammation},
  year    = {2006},
  doi     = {10.1186/1742-2094-3-27},
  pmid    = {17005052},
  url     = {https://doi.org/10.1186/1742-2094-3-27}
}

@article{abdi2006-16914840,
  author  = {Abdi, F. and Quinn, J. F. and Jankovic, J. and McIntosh, M. and Leverenz, J. B. and Peskind, E. and Nixon, R. and Nutt, J. and others},
  title   = {{Detection of biomarkers with a multiplex quantitative proteomic platform in cerebrospinal fluid of patients with neurodegenerative disorders}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2006},
  doi     = {10.3233/jad-2006-9309},
  pmid    = {16914840},
  url     = {https://doi.org/10.3233/jad-2006-9309}
}

@article{bonifati2007-16698083,
  author  = {Bonifati, D. M. and Kishore, U.},
  title   = {{Role of complement in neurodegeneration and neuroinflammation}},
  journal = {Molecular immunology},
  year    = {2007},
  doi     = {10.1016/j.molimm.2006.03.007},
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  author  = {Brown, Thomas Huntington and James, Sarah‐Naomi and Nicholas, Jennifer M. and Keuss, Sarah E and Keshavan, Ashvini and Malone, Ian B. and Coath, William and Murray‐Smith, Heidi and others},
  title   = {{Association of Increase in White Matter Hyperintensity Volume With Rate of Hippocampal Atrophy in a Population-Based Study of Aging}},
  journal = {Neurology},
  year    = {2025},
  doi     = {10.1212/wnl.0000000000213975},
  pmid    = {40829101},
  url     = {https://doi.org/10.1212/wnl.0000000000213975}
}

@article{chia2025-40826098,
  author  = {Chia, Sook‐Yoong and Li, Mengwei and Li, Zigang and Tu, Haitao and Lee, Jolene Wei Ling and Qiu, Lifeng and Ling, Jingjing and Reynolds, Richard J. and others},
  title   = {{Single-nucleus transcriptomics reveals a distinct microglial state and increased MSR1-mediated phagocytosis as common features across dementia subtypes}},
  journal = {Genome Medicine},
  year    = {2025},
  doi     = {10.1186/s13073-025-01519-4},
  pmid    = {40826098},
  url     = {https://doi.org/10.1186/s13073-025-01519-4}
}

@article{albanus2025-40737431,
  author  = {Albanus, Ricardo D’Oliveira and Finan, Gina M. and Brase, Logan and Sweeney, Nicholas and Kim, Tae Yeon and Chen, Shuo and Ryoo, Yeonsu and others},
  title   = {{Systematic analysis of cellular cross-talk reveals a role for SEMA6D-TREM2 regulating microglial function in Alzheimer’s disease}},
  journal = {Science Translational Medicine},
  year    = {2025},
  doi     = {10.1126/scitranslmed.adx0027},
  pmid    = {40737431},
  url     = {https://doi.org/10.1126/scitranslmed.adx0027}
}

@article{cen2025-40731233,
  author  = {Cen, Si and Wang, Lijuan and Qiu, Meiling and Xu, Zhongqiang and Xu, Li and Bao, Rui and Tang, Xiaolei and Gong, Juanyu and others},
  title   = {{Cholinergic basal forebrain atrophy accelerates cognitive decline via cortical thinning: The moderating role of amyloid-β pathology in preclinical Alzheimer’s disease}},
  journal = {The Journal of Prevention of Alzheimer s Disease},
  year    = {2025},
  doi     = {10.1016/j.tjpad.2025.100315},
  pmid    = {40731233},
  url     = {https://doi.org/10.1016/j.tjpad.2025.100315}
}

@article{hooper2025-40706903,
  author  = {Hooper, Claudie and González, Emmanuel and Coley, Nicola and Vellas, Bruno and Guyonnet, Sophie},
  title   = {{Cross-sectional associations of plasma vitamin D with plasma phosphorylated tau-181 and plasma neurofilament light chain in older adults with memory complaints}},
  journal = {Neurobiology of Disease},
  year    = {2025},
  doi     = {10.1016/j.nbd.2025.107041},
  pmid    = {40706903},
  url     = {https://doi.org/10.1016/j.nbd.2025.107041}
}

@article{leone2025-40712373,
  author  = {Leone, Riccardo and Kobeleva, Xenia},
  title   = {{White matter hyperintensities contribute to early cortical thinning in addition to tau in aging}},
  journal = {Neurobiology of Aging},
  year    = {2025},
  doi     = {10.1016/j.neurobiolaging.2025.07.007},
  pmid    = {40712373},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2025.07.007}
}

@article{tian2025-40592323,
  author  = {Tian, Min and Kawaguchi, Riki and Shen, Yang and Machnicki, Michał and Villegas, Nikole G. and Cooper, Delaney R. and Montgomery, Natalia and Cai, Ying and others},
  title   = {{Deconstructing the intercellular interactome in vascular dementia with focal ischemia for therapeutic applications}},
  journal = {Cell},
  year    = {2025},
  doi     = {10.1016/j.cell.2025.06.002},
  pmid    = {40592323},
  url     = {https://doi.org/10.1016/j.cell.2025.06.002}
}

@article{lisgaras2025-40642994,
  author  = {Lisgaras, Christos Panagiotis and Giménez, Sandra and Carmona‐Iragui, María and Maure‐Blesa, Lucía and Blessing, Esther and Fortea, Juan and Osorio, Ricardo S.},
  title   = {{High‐frequency oscillations >250 Hz in people with Down syndrome and associated Alzheimer's disease dementia}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz.70386},
  pmid    = {40642994},
  url     = {https://doi.org/10.1002/alz.70386}
}

@article{iyer2025-40527900,
  author  = {Iyer, Abhirami Kannan and Vermunt, Lisa and Mirfakhar, Farzaneh Sadat and Minaya, Miguel and Acquarone, Mariana and Koppisetti, Rama K. and Renganathan, Arun and You, Shih‐Feng and others},
  title   = {{Cell autonomous microglia defects in a stem cell model of frontotemporal dementia tau}},
  journal = {Molecular Psychiatry},
  year    = {2025},
  doi     = {10.1038/s41380-025-03073-2},
  pmid    = {40527900},
  url     = {https://doi.org/10.1038/s41380-025-03073-2}
}

@article{dellar2025-40495245,
  author  = {Dellar, Elizabeth R. and Nikel, Lara and Fowler, Stephanie L. and Vahsen, Björn Friedhelm and Dafinca, Ruxandra and Feneberg, Emily and Talbot, Kevin and Turner, Martin R. and others},
  title   = {{Extracellular vesicles in TDP-43 proteinopathies: pathogenesis and biomarker potential}},
  journal = {Molecular Neurodegeneration},
  year    = {2025},
  doi     = {10.1186/s13024-025-00859-4},
  pmid    = {40495245},
  url     = {https://doi.org/10.1186/s13024-025-00859-4}
}

@article{gaetani2025-40405270,
  author  = {Gaetani, Lorenzo and Bellomo, Giovanni and Chiasserini, Davide and De Rocker, Charlotte and Goossens, Julie and Paoletti, Federico Paolini and Vanmechelen, Eugeen and Parnetti, Lucilla},
  title   = {{Influence of co-pathology on CSF and plasma synaptic markers SNAP25 and VAMP2 in Alzheimer’s disease and Parkinson’s disease}},
  journal = {Alzheimer s Research \& Therapy},
  year    = {2025},
  doi     = {10.1186/s13195-025-01762-2},
  pmid    = {40405270},
  url     = {https://doi.org/10.1186/s13195-025-01762-2}
}

@article{castelot2025-40336092,
  author  = {Castelot, Romain and Zaréa, Aline and Wallon, David and Rovelet‐Lecrux, Anne and Schramm, Catherine and Quillard‐Muraine, Muriel and Beaume, Anne and Blanc, Frédéric and others},
  title   = {{Soluble SorLA in CSF, a novel biomarker to explore disrupted trafficking of SorLA protein in Alzheimer disease}},
  journal = {Alzheimer s Research \& Therapy},
  year    = {2025},
  doi     = {10.1186/s13195-025-01748-0},
  pmid    = {40336092},
  url     = {https://doi.org/10.1186/s13195-025-01748-0}
}

@article{brumberg2025-40246540,
  author  = {Brumberg, Joachim and Schröter, Nils and Blazhenets, Ganna and Omrane, Mohamed Aymen and Volz, Christian H. and Weiller, Cornelius and Rijntjes, Michel and Frings, Lars and others},
  title   = {{[18F]Florzolotau PET for the Differential Diagnosis of Parkinsonism in Patients with Suspected 4-Repeat Tauopathies}},
  journal = {Journal of Nuclear Medicine},
  year    = {2025},
  doi     = {10.2967/jnumed.124.268956},
  pmid    = {40246540},
  url     = {https://doi.org/10.2967/jnumed.124.268956}
}

@article{corucci2025-40198794,
  author  = {Corucci, Giacomo and Vadukul, Devkee M. and Paracini, Nicoló and Laux, Valérie and Batchu, Krishna Chaithanya and Aprile, Francesco A. and Pastore, Annalisa},
  title   = {{Membrane Charge Drives the Aggregation of TDP-43 Pathological Fragments}},
  journal = {Journal of the American Chemical Society},
  year    = {2025},
  doi     = {10.1021/jacs.5c00594},
  pmid    = {40198794},
  url     = {https://doi.org/10.1021/jacs.5c00594}
}

@article{padillagodinez2025-40212715,
  author  = {Padilla-Godínez, Francisco Javier and Vázquez-García, Eunice Ruth and Trujillo-Villagrán, María Isabel and Soto-Rojas, Luis Oskar and Palomero‐Rivero, Marcela and Hernández‐González, Omar and Pérez-Eugenio, Francisco and Collazo-Navarrete, Omar and others},
  title   = {{α-synuclein and tau: interactions, cross-seeding, and the redefinition of synucleinopathies as complex proteinopathies}},
  journal = {Frontiers in Neuroscience},
  year    = {2025},
  doi     = {10.3389/fnins.2025.1570553},
  pmid    = {40212715},
  url     = {https://doi.org/10.3389/fnins.2025.1570553}
}

@article{kleinerova2025-40131525,
  author  = {Kleinerová, Jana and Tahedl, Marlene and McKenna, Mary Clare and Garcia-Gallardo, Angela and Hutchinson, Siobhán and Hardiman, Orla M. and Raoul, Cédric and Ango, Fabrice and others},
  title   = {{Cerebellar dysfunction in frontotemporal dementia: intra-cerebellar pathology and cerebellar network degeneration}},
  journal = {Journal of Neurology},
  year    = {2025},
  doi     = {10.1007/s00415-025-13046-8},
  pmid    = {40131525},
  url     = {https://doi.org/10.1007/s00415-025-13046-8}
}

@article{arriolainfante2025-40084922,
  author  = {Arriola-Infante, J. E. and Morcillo-Nieto, A. O. and Zsadanyi, S. E. and Franquesa-Mullerat, M. and Vaqué-Alcázar, L. and Rozalem-Aranha, M. and Arranz, J. and Í, Rodríguez-Baz and others},
  title   = {{Regional Brain Metabolism across the Alzheimer's Disease Continuum in Down Syndrome}},
  journal = {Annals of neurology},
  year    = {2025},
  doi     = {10.1002/ana.27226},
  pmid    = {40084922},
  url     = {https://doi.org/10.1002/ana.27226}
}

@article{dang2025-40032118,
  author  = {Dang, Mei and Wu, Longjiang and Zhang, Xiaoying},
  title   = {{Structural insights and milestones in TDP-43 research: A comprehensive review of its pathological and therapeutic advances}},
  journal = {International Journal of Biological Macromolecules},
  year    = {2025},
  doi     = {10.1016/j.ijbiomac.2025.141677},
  pmid    = {40032118},
  url     = {https://doi.org/10.1016/j.ijbiomac.2025.141677}
}

@article{nordvall2025-40054389,
  author  = {Nordvall, Gunnar and Yan, Ping and Agholme, Lotta and Lundkvist, Johan and Sandin, Johan and Biverstål, Henrik and Winblad, Bengt G. and Zetterberg, Henrik and others},
  title   = {{γ-Secretase modulation inhibits amyloid plaque formation and growth and stimulates plaque regression in amyloid precursor protein/presenilin-1 mice}},
  journal = {Journal of Pharmacology and Experimental Therapeutics},
  year    = {2025},
  doi     = {10.1016/j.jpet.2025.103400},
  pmid    = {40054389},
  url     = {https://doi.org/10.1016/j.jpet.2025.103400}
}

@article{mwale2025-39827337,
  author  = {Mwale, Pharaoh Fellow and Hsieh, Cheng-Ta and Yen, Ting‐Lin and Jan, Jing‐Shiun and Taliyan, Rajeev and Yang, Chih‐Hao and Yang, Wen‐Bin},
  title   = {{Chitinase-3-like-1: a multifaceted player in neuroinflammation and degenerative pathologies with therapeutic implications}},
  journal = {Molecular Neurodegeneration},
  year    = {2025},
  doi     = {10.1186/s13024-025-00801-8},
  pmid    = {39827337},
  url     = {https://doi.org/10.1186/s13024-025-00801-8}
}

@article{cascio2025-39809992,
  author  = {Cascio, Filippa Lo and Park, S.J. and Sengupta, Urmi and Puangmalai, Nicha and Bhatt, Nemil N. and Shchankin, Nikita and Jerez, Cynthia and Moreno, Naomi and others},
  title   = {{Brain-derived tau oligomer polymorphs: distinct aggregations, stability profiles, and biological activities}},
  journal = {Communications Biology},
  year    = {2025},
  doi     = {10.1038/s42003-025-07499-w},
  pmid    = {39809992},
  url     = {https://doi.org/10.1038/s42003-025-07499-w}
}

@article{demeyer2025-40620474,
  author  = {De Meyer, Steffi and Alali, Soha and Laroy, Maarten and Casteele, Thomas Vande and Van Cauwenberge, Margot and Goossens, Julie and De Rocker, Charlotte and Vanbrabant, Jeroen and others},
  title   = {{Plasma vesicle-associated membrane protein 2 and glial fibrillary acidic protein associate with synaptic density in older adults without dementia}},
  journal = {Brain Communications},
  year    = {2025},
  doi     = {10.1093/braincomms/fcaf207},
  pmid    = {40620474},
  url     = {https://doi.org/10.1093/braincomms/fcaf207}
}

@article{jin2025-41234528,
  author  = {Jin, Xinhu and Xing, Yi and Lyu, Baihan and Ding, Junhua and Wang, Xiuyi and Du, Yi and Tang, Yi},
  title   = {{Cognitive training reorganizes lateralization of fronto-parietal network in vascular cognitive impairment}},
  journal = {Brain Communications},
  year    = {2025},
  doi     = {10.1093/braincomms/fcaf394},
  pmid    = {41234528},
  url     = {https://doi.org/10.1093/braincomms/fcaf394}
}

@article{jackson2024-38504517,
  author  = {Jackson, R. J. and Keiser, M. S. and Meltzer, J. C. and Fykstra, D. P. and Dierksmeier, S. E. and Hajizadeh, S. and Kreuzer, J. and Morris, R. and others},
  title   = {{APOE2 gene therapy reduces amyloid deposition and improves markers of neuroinflammation and neurodegeneration in a mouse model of Alzheimer disease}},
  journal = {Molecular therapy : the journal of the American Society of Gene Therapy},
  year    = {2024},
  doi     = {10.1016/j.ymthe.2024.03.024},
  pmid    = {38504517},
  url     = {https://doi.org/10.1016/j.ymthe.2024.03.024}
}

@article{kiianitsa2024-9e48f8fa,
  author  = {Kiianitsa, K. and Lukes, M. E. and Hayes, B. J. and Brutman, J. N. and Valdmanis, P. N. and Bird, T. D. and Raskind, W. H. and Korvatska, O.},
  title   = {{TREM2 variants that cause early dementia and increase Alzheimer's disease risk affect gene splicing}},
  journal = {Brain},
  year    = {2024}
}

@article{creekmore2024-37832941,
  author  = {Creekmore, B. C. and Watanabe, R. and Lee, E. B.},
  title   = {{Neurodegenerative Disease Tauopathies}},
  journal = {Annual review of pathology},
  year    = {2024},
  doi     = {10.1146/annurev-pathmechdis-051222-120750},
  pmid    = {37832941},
  url     = {https://doi.org/10.1146/annurev-pathmechdis-051222-120750}
}

@article{guo2023-37133566,
  author  = {Guo, X. and Li, B. and Wen, C. and Zhang, F. and Xiang, X. and Nie, L. and Chen, J. and Mao, L.},
  title   = {{TREM2 promotes cholesterol uptake and foam cell formation in atherosclerosis}},
  journal = {Cellular and molecular life sciences : CMLS},
  year    = {2023},
  doi     = {10.1007/s00018-023-04786-9},
  pmid    = {37133566},
  url     = {https://doi.org/10.1007/s00018-023-04786-9}
}

@article{molgora2023-36989543,
  author  = {Molgora, M. and Liu, Y. A. and Colonna, M. and Cella, M.},
  title   = {{TREM2: A new player in the tumor microenvironment}},
  journal = {Seminars in immunology},
  year    = {2023},
  doi     = {10.1016/j.smim.2023.101739},
  pmid    = {36989543},
  url     = {https://doi.org/10.1016/j.smim.2023.101739}
}

@article{lin2023-36524682,
  author  = {Lin, P. B. and Tsai, A. P. and Soni, D. and Lee-Gosselin, A. and Moutinho, M. and Puntambekar, S. S. and Landreth, G. E. and Lamb, B. T. and others},
  title   = {{INPP5D deficiency attenuates amyloid pathology in a mouse model of Alzheimer's disease}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2023},
  doi     = {10.1002/alz.12849},
  pmid    = {36524682},
  url     = {https://doi.org/10.1002/alz.12849}
}

@article{yang2023-36259513,
  author  = {Yang, T. and Zhang, S. and Yuan, H. and Wang, Y. and Cai, L. and Chen, H. and Wang, X. and Song, D. and others},
  title   = {{Platinum-Based TREM2 Inhibitor Suppresses Tumors by Remodeling the Immunosuppressive Microenvironment}},
  journal = {Angewandte Chemie (International ed. in English)},
  year    = {2023},
  doi     = {10.1002/anie.202213337},
  pmid    = {36259513},
  url     = {https://doi.org/10.1002/anie.202213337}
}

@article{dayananda2023-36174883,
  author  = {Dayananda, K. K. and Ahmed, S. and Wang, D. and Polis, B. and Islam, R. and Kaffman, A.},
  title   = {{Early life stress impairs synaptic pruning in the developing hippocampus}},
  journal = {Brain, behavior, and immunity},
  year    = {2023},
  doi     = {10.1016/j.bbi.2022.09.014},
  pmid    = {36174883},
  url     = {https://doi.org/10.1016/j.bbi.2022.09.014}
}

@article{giannini2022-36071460,
  author  = {Giannini, G. and Baiardi, S. and Dellavalle, S. and Zenesini, C. and Cevoli, S. and Danner, N. and Jyrkkänen, H. K. and Rossi, M. and others},
  title   = {{In vivo assessment of Lewy body and beta-amyloid copathologies in idiopathic normal pressure hydrocephalus: prevalence and associations with clinical features and surgery outcome}},
  journal = {Fluids and barriers of the CNS},
  year    = {2022},
  doi     = {10.1186/s12987-022-00368-2},
  pmid    = {36071460},
  url     = {https://doi.org/10.1186/s12987-022-00368-2}
}

@article{wang2022-36068223,
  author  = {Wang, Y. and Cao, C. and Zhu, Y. and Fan, H. and Liu, Q. and Liu, Y. and Chen, K. and Wu, Y. and others},
  title   = {{TREM2/β-catenin attenuates NLRP3 inflammasome-mediated macrophage pyroptosis to promote bacterial clearance of pyogenic bacteria}},
  journal = {Cell death \& disease},
  year    = {2022},
  doi     = {10.1038/s41419-022-05193-x},
  pmid    = {36068223},
  url     = {https://doi.org/10.1038/s41419-022-05193-x}
}

@article{fracassi2023-35816404,
  author  = {Fracassi, A. and Marcatti, M. and Tumurbaatar, B. and Woltjer, R. and Moreno, S. and Taglialatela, G.},
  title   = {{TREM2-induced activation of microglia contributes to synaptic integrity in cognitively intact aged individuals with Alzheimer's neuropathology}},
  journal = {Brain pathology (Zurich, Switzerland)},
  year    = {2023},
  doi     = {10.1111/bpa.13108},
  pmid    = {35816404},
  url     = {https://doi.org/10.1111/bpa.13108}
}

@article{xue2022-35847502,
  author  = {Xue, T. and Ji, J. and Sun, Y. and Huang, X. and Cai, Z. and Yang, J. and Guo, W. and Guo, R. and others},
  title   = {{Sphingosine-1-phosphate, a novel TREM2 ligand, promotes microglial phagocytosis to protect against ischemic brain injury}},
  journal = {Acta pharmaceutica Sinica. B},
  year    = {2022},
  doi     = {10.1016/j.apsb.2021.10.012},
  pmid    = {35847502},
  url     = {https://doi.org/10.1016/j.apsb.2021.10.012}
}

@article{baril2022-34310026,
  author  = {Baril, A. A. and Beiser, A. S. and Sanchez, E. and Mysliwiec, V. and Redline, S. and Gottlieb, D. J. and O'Connor, G. T. and Gonzales, M. M. and others},
  title   = {{Insomnia symptom severity and cognitive performance: Moderating role of APOE genotype}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2022},
  doi     = {10.1002/alz.12405},
  pmid    = {34310026},
  url     = {https://doi.org/10.1002/alz.12405}
}

@article{yang2021-33567283,
  author  = {Yang, H. S. and Onos, K. D. and Choi, K. and Keezer, K. J. and Skelly, D. A. and Carter, G. W. and Howell, G. R.},
  title   = {{Natural genetic variation determines microglia heterogeneity in wild-derived mouse models of Alzheimer's disease}},
  journal = {Cell reports},
  year    = {2021},
  doi     = {10.1016/j.celrep.2021.108739},
  pmid    = {33567283},
  url     = {https://doi.org/10.1016/j.celrep.2021.108739}
}

@article{qu2020-33139402,
  author  = {Qu, W. and Li, L.},
  title   = {{Loss of TREM2 Confers Resilience to Synaptic and Cognitive Impairment in Aged Mice}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2020},
  doi     = {10.1523/jneurosci.2193-20.2020},
  pmid    = {33139402},
  url     = {https://doi.org/10.1523/jneurosci.2193-20.2020}
}

@article{jadhav2020-33115519,
  author  = {Jadhav, V. S. and Lin, P. B. C. and Pennington, T. and Di Prisco, G. V. and Jannu, A. J. and Xu, G. and Moutinho, M. and Zhang, J. and others},
  title   = {{Trem2 Y38C mutation and loss of Trem2 impairs neuronal synapses in adult mice}},
  journal = {Molecular neurodegeneration},
  year    = {2020},
  doi     = {10.1186/s13024-020-00409-0},
  pmid    = {33115519},
  url     = {https://doi.org/10.1186/s13024-020-00409-0}
}

@article{kober2020-33090700,
  author  = {Kober, D. L. and Stuchell-Brereton, M. D. and Kluender, C. E. and Dean, H. B. and Strickland, M. R. and Steinberg, D. F. and Nelson, S. S. and Baban, B. and others},
  title   = {{Functional insights from biophysical study of TREM2 interactions with apoE and Aβ1-42}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2020},
  doi     = {10.1002/alz.12194},
  pmid    = {33090700},
  url     = {https://doi.org/10.1002/alz.12194}
}

@article{yang2020-32635934,
  author  = {Yang, J. and Fu, Z. and Zhang, X. and Xiong, M. and Meng, L. and Zhang, Z.},
  title   = {{TREM2 ectodomain and its soluble form in Alzheimer's disease}},
  journal = {Journal of neuroinflammation},
  year    = {2020},
  doi     = {10.1186/s12974-020-01878-2},
  pmid    = {32635934},
  url     = {https://doi.org/10.1186/s12974-020-01878-2}
}

@article{berger2020-32418723,
  author  = {Berger, T. and Lee, H. and Young, A. H. and Aarsland, D. and Thuret, S.},
  title   = {{Adult Hippocampal Neurogenesis in Major Depressive Disorder and Alzheimer's Disease}},
  journal = {Trends in molecular medicine},
  year    = {2020},
  doi     = {10.1016/j.molmed.2020.03.010},
  pmid    = {32418723},
  url     = {https://doi.org/10.1016/j.molmed.2020.03.010}
}

@article{bocchetta2020-31696638,
  author  = {Bocchetta, M. and Iglesias, J. E. and Neason, M. and Cash, D. M. and Warren, J. D. and Rohrer, J. D.},
  title   = {{Thalamic nuclei in frontotemporal dementia: Mediodorsal nucleus involvement is universal but pulvinar atrophy is unique to C9orf72}},
  journal = {Human brain mapping},
  year    = {2020},
  doi     = {10.1002/hbm.24856},
  pmid    = {31696638},
  url     = {https://doi.org/10.1002/hbm.24856}
}

@article{yamazaki2020-31665905,
  author  = {Yamazaki, Y. and Shinohara, M. and Yamazaki, A. and Ren, Y. and Asmann, Y. W. and Kanekiyo, T. and Bu, G.},
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@article{gu2009-19240035,
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  title   = {{beta-Amyloid impairs AMPA receptor trafficking and function by reducing Ca2+/calmodulin-dependent protein kinase II synaptic distribution}},
  journal = {The Journal of biological chemistry},
  year    = {2009},
  doi     = {10.1074/jbc.m806508200},
  pmid    = {19240035},
  url     = {https://doi.org/10.1074/jbc.m806508200}
}

@article{maetzler2009-19162186,
  author  = {Maetzler, W. and Liepelt, I. and Reimold, M. and Reischl, G. and Solbach, C. and Becker, C. and Schulte, C. and Leyhe, T. and others},
  title   = {{Cortical PIB binding in Lewy body disease is associated with Alzheimer-like characteristics}},
  journal = {Neurobiology of disease},
  year    = {2009},
  doi     = {10.1016/j.nbd.2008.12.008},
  pmid    = {19162186},
  url     = {https://doi.org/10.1016/j.nbd.2008.12.008}
}

@article{schwab2008-19018245,
  author  = {Schwab, C. and Arai, T. and Hasegawa, M. and Yu, S. and McGeer, P. L.},
  title   = {{Colocalization of transactivation-responsive DNA-binding protein 43 and huntingtin in inclusions of Huntington disease}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2008},
  doi     = {10.1097/nen.0b013e31818e8951},
  pmid    = {19018245},
  url     = {https://doi.org/10.1097/nen.0b013e31818e8951}
}

@article{boissonneault2009-18986979,
  author  = {Boissonneault, V. and Plante, I. and Rivest, S. and Provost, P.},
  title   = {{MicroRNA-298 and microRNA-328 regulate expression of mouse beta-amyloid precursor protein-converting enzyme 1}},
  journal = {The Journal of biological chemistry},
  year    = {2009},
  doi     = {10.1074/jbc.m807530200},
  pmid    = {18986979},
  url     = {https://doi.org/10.1074/jbc.m807530200}
}

@article{muller2008-18603345,
  author  = {Müller, T. and Meyer, H. E. and Egensperger, R. and Marcus, K.},
  title   = {{The amyloid precursor protein intracellular domain (AICD) as modulator of gene expression, apoptosis, and cytoskeletal dynamics-relevance for Alzheimer's disease}},
  journal = {Progress in neurobiology},
  year    = {2008},
  doi     = {10.1016/j.pneurobio.2008.05.002},
  pmid    = {18603345},
  url     = {https://doi.org/10.1016/j.pneurobio.2008.05.002}
}

@article{thirumangalakudi2008-18410513,
  author  = {Thirumangalakudi, L. and Prakasam, A. and Zhang, R. and Bimonte-Nelson, H. and Sambamurti, K. and Kindy, M. S. and Bhat, N. R.},
  title   = {{High cholesterol-induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice}},
  journal = {Journal of neurochemistry},
  year    = {2008},
  doi     = {10.1111/j.1471-4159.2008.05415.x},
  pmid    = {18410513},
  url     = {https://doi.org/10.1111/j.1471-4159.2008.05415.x}
}

@article{valstar2008-18392742,
  author  = {Valstar, M. J. and Ruijter, G. J. and van Diggelen, O. P. and Poorthuis, B. J. and Wijburg, F. A.},
  title   = {{Sanfilippo syndrome: a mini-review}},
  journal = {Journal of inherited metabolic disease},
  year    = {2008},
  doi     = {10.1007/s10545-008-0838-5},
  pmid    = {18392742},
  url     = {https://doi.org/10.1007/s10545-008-0838-5}
}

@article{whalley2008-18258638,
  author  = {Whalley, L. J. and Deary, I. J. and Starr, J. M. and Wahle, K. W. and Rance, K. A. and Bourne, V. J. and Fox, H. C.},
  title   = {{n-3 Fatty acid erythrocyte membrane content, APOE varepsilon4, and cognitive variation: an observational follow-up study in late adulthood}},
  journal = {The American journal of clinical nutrition},
  year    = {2008},
  doi     = {10.1093/ajcn/87.2.449},
  pmid    = {18258638},
  url     = {https://doi.org/10.1093/ajcn/87.2.449}
}

@article{donnelly2008-18086681,
  author  = {Donnelly, P. S. and Caragounis, A. and Du, T. and Laughton, K. M. and Volitakis, I. and Cherny, R. A. and Sharples, R. A. and Hill, A. F. and others},
  title   = {{Selective intracellular release of copper and zinc ions from bis(thiosemicarbazonato) complexes reduces levels of Alzheimer disease amyloid-beta peptide}},
  journal = {The Journal of biological chemistry},
  year    = {2008},
  doi     = {10.1074/jbc.m705957200},
  pmid    = {18086681},
  url     = {https://doi.org/10.1074/jbc.m705957200}
}

@article{bell2007-17913914,
  author  = {Bell, K. F. and Bennett, D. A. and Cuello, A. C.},
  title   = {{Paradoxical upregulation of glutamatergic presynaptic boutons during mild cognitive impairment}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2007},
  doi     = {10.1523/jneurosci.3269-07.2007},
  pmid    = {17913914},
  url     = {https://doi.org/10.1523/jneurosci.3269-07.2007}
}

@article{goldman2008-17727823,
  author  = {Goldman, A. L. and Pezawas, L. and Mattay, V. S. and Fischl, B. and Verchinski, B. A. and Zoltick, B. and Weinberger, D. R. and Meyer-Lindenberg, A.},
  title   = {{Heritability of brain morphology related to schizophrenia: a large-scale automated magnetic resonance imaging segmentation study}},
  journal = {Biological psychiatry},
  year    = {2008},
  doi     = {10.1016/j.biopsych.2007.06.006},
  pmid    = {17727823},
  url     = {https://doi.org/10.1016/j.biopsych.2007.06.006}
}

@article{honea2008-17689500,
  author  = {Honea, R. A. and Meyer-Lindenberg, A. and Hobbs, K. B. and Pezawas, L. and Mattay, V. S. and Egan, M. F. and Verchinski, B. and Passingham, R. E. and others},
  title   = {{Is gray matter volume an intermediate phenotype for schizophrenia? A voxel-based morphometry study of patients with schizophrenia and their healthy siblings}},
  journal = {Biological psychiatry},
  year    = {2008},
  doi     = {10.1016/j.biopsych.2007.05.027},
  pmid    = {17689500},
  url     = {https://doi.org/10.1016/j.biopsych.2007.05.027}
}

@article{jankowsky2007-17556372,
  author  = {Jankowsky, J. L. and Younkin, L. H. and Gonzales, V. and Fadale, D. J. and Slunt, H. H. and Lester, H. A. and Younkin, S. G. and Borchelt, D. R.},
  title   = {{Rodent A beta modulates the solubility and distribution of amyloid deposits in transgenic mice}},
  journal = {The Journal of biological chemistry},
  year    = {2007},
  doi     = {10.1074/jbc.m611050200},
  pmid    = {17556372},
  url     = {https://doi.org/10.1074/jbc.m611050200}
}

@article{nelson2007-17431506,
  author  = {Nelson, O. and Tu, H. and Lei, T. and Bentahir, M. and de Strooper, B. and Bezprozvanny, I.},
  title   = {{Familial Alzheimer disease-linked mutations specifically disrupt Ca2+ leak function of presenilin 1}},
  journal = {The Journal of clinical investigation},
  year    = {2007},
  doi     = {10.1172/jci30447},
  pmid    = {17431506},
  url     = {https://doi.org/10.1172/jci30447}
}

@article{westmark2007-17298186,
  author  = {Westmark, C. J. and Malter, J. S.},
  title   = {{FMRP mediates mGluR5-dependent translation of amyloid precursor protein}},
  journal = {PLoS biology},
  year    = {2007},
  doi     = {10.1371/journal.pbio.0050052},
  pmid    = {17298186},
  url     = {https://doi.org/10.1371/journal.pbio.0050052}
}

@article{venneti2006-17156911,
  author  = {Venneti, S. and Lopresti, B. J. and Wiley, C. A.},
  title   = {{The peripheral benzodiazepine receptor (Translocator protein 18kDa) in microglia: from pathology to imaging}},
  journal = {Progress in neurobiology},
  year    = {2006},
  doi     = {10.1016/j.pneurobio.2006.10.002},
  pmid    = {17156911},
  url     = {https://doi.org/10.1016/j.pneurobio.2006.10.002}
}

@article{wilkinson2006-17094809,
  author  = {Wilkinson, B. L. and Landreth, G. E.},
  title   = {{The microglial NADPH oxidase complex as a source of oxidative stress in Alzheimer's disease}},
  journal = {Journal of neuroinflammation},
  year    = {2006},
  doi     = {10.1186/1742-2094-3-30},
  pmid    = {17094809},
  url     = {https://doi.org/10.1186/1742-2094-3-30}
}

@article{nicoll2006-17086100,
  author  = {Nicoll, J. A. and Barton, E. and Boche, D. and Neal, J. W. and Ferrer, I. and Thompson, P. and Vlachouli, C. and Wilkinson, D. and others},
  title   = {{Abeta species removal after abeta42 immunization}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2006},
  doi     = {10.1097/01.jnen.0000240466.10758.ce},
  pmid    = {17086100},
  url     = {https://doi.org/10.1097/01.jnen.0000240466.10758.ce}
}

@article{mclarnon2006-17086106,
  author  = {McLarnon, J. G. and Ryu, J. K. and Walker, D. G. and Choi, H. B.},
  title   = {{Upregulated expression of purinergic P2X(7) receptor in Alzheimer disease and amyloid-beta peptide-treated microglia and in peptide-injected rat hippocampus}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2006},
  doi     = {10.1097/01.jnen.0000240470.97295.d3},
  pmid    = {17086106},
  url     = {https://doi.org/10.1097/01.jnen.0000240470.97295.d3}
}

@article{li2006-17186461,
  author  = {Li, D. and Parks, S. B. and Kushner, J. D. and Nauman, D. and Burgess, D. and Ludwigsen, S. and Partain, J. and Nixon, R. R. and others},
  title   = {{Mutations of presenilin genes in dilated cardiomyopathy and heart failure}},
  journal = {American journal of human genetics},
  year    = {2006},
  doi     = {10.1086/509900},
  pmid    = {17186461},
  url     = {https://doi.org/10.1086/509900}
}

@article{dunfee2006-17015824,
  author  = {Dunfee, R. L. and Thomas, E. R. and Gorry, P. R. and Wang, J. and Taylor, J. and Kunstman, K. and Wolinsky, S. M. and Gabuzda, D.},
  title   = {{The HIV Env variant N283 enhances macrophage tropism and is associated with brain infection and dementia}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2006},
  doi     = {10.1073/pnas.0605513103},
  pmid    = {17015824},
  url     = {https://doi.org/10.1073/pnas.0605513103}
}

@article{zerbinatti2006-17012232,
  author  = {Zerbinatti, C. V. and Wahrle, S. E. and Kim, H. and Cam, J. A. and Bales, K. and Paul, S. M. and Holtzman, D. M. and Bu, G.},
  title   = {{Apolipoprotein E and low density lipoprotein receptor-related protein facilitate intraneuronal Abeta42 accumulation in amyloid model mice}},
  journal = {The Journal of biological chemistry},
  year    = {2006},
  doi     = {10.1074/jbc.m604436200},
  pmid    = {17012232},
  url     = {https://doi.org/10.1074/jbc.m604436200}
}

@article{dodson2006-16957580,
  author  = {Dodson, S. E. and Gearing, M. and Lippa, C. F. and Montine, T. J. and Levey, A. I. and Lah, J. J.},
  title   = {{LR11/SorLA expression is reduced in sporadic Alzheimer disease but not in familial Alzheimer disease}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2006},
  doi     = {10.1097/01.jnen.0000228205.19915.20},
  pmid    = {16957580},
  url     = {https://doi.org/10.1097/01.jnen.0000228205.19915.20}
}

@article{martinruiz2006-16685698,
  author  = {Martin-Ruiz, C. and Dickinson, H. O. and Keys, B. and Rowan, E. and Kenny, R. A. and Von Zglinicki, T.},
  title   = {{Telomere length predicts poststroke mortality, dementia, and cognitive decline}},
  journal = {Annals of neurology},
  year    = {2006},
  doi     = {10.1002/ana.20869},
  pmid    = {16685698},
  url     = {https://doi.org/10.1002/ana.20869}
}

@article{boekhoorn2006-16814555,
  author  = {Boekhoorn, K. and Joels, M. and Lucassen, P. J.},
  title   = {{Increased proliferation reflects glial and vascular-associated changes, but not neurogenesis in the presenile Alzheimer hippocampus}},
  journal = {Neurobiology of disease},
  year    = {2006},
  doi     = {10.1016/j.nbd.2006.04.017},
  pmid    = {16814555},
  url     = {https://doi.org/10.1016/j.nbd.2006.04.017}
}

@article{ble2006-16567378,
  author  = {Ble, A. and Cherubini, A. and Volpato, S. and Bartali, B. and Walston, J. D. and Windham, B. G. and Bandinelli, S. and Lauretani, F. and others},
  title   = {{Lower plasma vitamin E levels are associated with the frailty syndrome: the InCHIANTI study}},
  journal = {The journals of gerontology. Series A, Biological sciences and medical sciences},
  year    = {2006},
  doi     = {10.1093/gerona/61.3.278},
  pmid    = {16567378},
  url     = {https://doi.org/10.1093/gerona/61.3.278}
}

@article{butterfield2006-16413966,
  author  = {Butterfield, D. A. and Reed, T. and Perluigi, M. and De Marco, C. and Coccia, R. and Cini, C. and Sultana, R.},
  title   = {{Elevated protein-bound levels of the lipid peroxidation product, 4-hydroxy-2-nonenal, in brain from persons with mild cognitive impairment}},
  journal = {Neuroscience letters},
  year    = {2006},
  doi     = {10.1016/j.neulet.2005.12.017},
  pmid    = {16413966},
  url     = {https://doi.org/10.1016/j.neulet.2005.12.017}
}

@article{wang2006-16364207,
  author  = {Wang, R. and Yan, H. and Tang, X. C.},
  title   = {{Progress in studies of huperzine A, a natural cholinesterase inhibitor from Chinese herbal medicine}},
  journal = {Acta pharmacologica Sinica},
  year    = {2006},
  doi     = {10.1111/j.1745-7254.2006.00255.x},
  pmid    = {16364207},
  url     = {https://doi.org/10.1111/j.1745-7254.2006.00255.x}
}

@article{cordle2005-16085653,
  author  = {Cordle, A. and Koenigsknecht-Talboo, J. and Wilkinson, B. and Limpert, A. and Landreth, G.},
  title   = {{Mechanisms of statin-mediated inhibition of small G-protein function}},
  journal = {The Journal of biological chemistry},
  year    = {2005},
  doi     = {10.1074/jbc.m505268200},
  pmid    = {16085653},
  url     = {https://doi.org/10.1074/jbc.m505268200}
}

@article{matsuda2005-15983050,
  author  = {Matsuda, S. and Giliberto, L. and Matsuda, Y. and Davies, P. and McGowan, E. and Pickford, F. and Ghiso, J. and Frangione, B. and others},
  title   = {{The familial dementia BRI2 gene binds the Alzheimer gene amyloid-beta precursor protein and inhibits amyloid-beta production}},
  journal = {The Journal of biological chemistry},
  year    = {2005},
  doi     = {10.1074/jbc.c500217200},
  pmid    = {15983050},
  url     = {https://doi.org/10.1074/jbc.c500217200}
}

@article{kang2005-15927426,
  author  = {Kang, D. C. and Su, Z. Z. and Sarkar, D. and Emdad, L. and Volsky, D. J. and Fisher, P. B.},
  title   = {{Cloning and characterization of HIV-1-inducible astrocyte elevated gene-1, AEG-1}},
  journal = {Gene},
  year    = {2005},
  doi     = {10.1016/j.gene.2005.04.006},
  pmid    = {15927426},
  url     = {https://doi.org/10.1016/j.gene.2005.04.006}
}

@article{sessa2004-15548205,
  author  = {Sessa, G. and Podini, P. and Mariani, M. and Meroni, A. and Spreafico, R. and Sinigaglia, F. and Colonna, M. and Panina, P. and others},
  title   = {{Distribution and signaling of TREM2/DAP12, the receptor system mutated in human polycystic lipomembraneous osteodysplasia with sclerosing leukoencephalopathy dementia}},
  journal = {The European journal of neuroscience},
  year    = {2004},
  doi     = {10.1111/j.1460-9568.2004.03729.x},
  pmid    = {15548205},
  url     = {https://doi.org/10.1111/j.1460-9568.2004.03729.x}
}

@article{giacobini2004-15304240,
  author  = {Giacobini, E.},
  title   = {{Cholinesterase inhibitors: new roles and therapeutic alternatives}},
  journal = {Pharmacological research},
  year    = {2004},
  doi     = {10.1016/j.phrs.2003.11.017},
  pmid    = {15304240},
  url     = {https://doi.org/10.1016/j.phrs.2003.11.017}
}

@article{dermaut2004-15122701,
  author  = {Dermaut, B. and Kumar-Singh, S. and Engelborghs, S. and Theuns, J. and Rademakers, R. and Saerens, J. and Pickut, B. A. and Peeters, K. and others},
  title   = {{A novel presenilin 1 mutation associated with Pick's disease but not beta-amyloid plaques}},
  journal = {Annals of neurology},
  year    = {2004},
  doi     = {10.1002/ana.20083},
  pmid    = {15122701},
  url     = {https://doi.org/10.1002/ana.20083}
}

@article{daws2003-12847223,
  author  = {Daws, Michael R. and Sullam, Paul M. and Niemi, Eréne C. and Chen, Thomas T. and Tchao, Nadia K. and Seaman, William E.},
  title   = {{Pattern Recognition by TREM-2: Binding of Anionic Ligands}},
  journal = {The Journal of Immunology},
  year    = {2003},
  doi     = {10.4049/jimmunol.171.2.594},
  pmid    = {12847223},
  url     = {https://doi.org/10.4049/jimmunol.171.2.594}
}

@article{nagele2003-12706236,
  author  = {Nagele, R. G. and D'Andrea, M. R. and Lee, H. and Venkataraman, V. and Wang, H. Y.},
  title   = {{Astrocytes accumulate A beta 42 and give rise to astrocytic amyloid plaques in Alzheimer disease brains}},
  journal = {Brain research},
  year    = {2003},
  doi     = {10.1016/s0006-8993(03)02361-8},
  pmid    = {12706236},
  url     = {https://doi.org/10.1016/s0006-8993(03)02361-8}
}

@article{schmid2002-12472885,
  author  = {Schmid, Christoph D. and Sautkulis, Lauren N. and Danielson, Patria E. and Cooper, Judith and Hasel, Karl W. and Hilbush, Brian S. and Sutcliffe, J. Gregor and Carson, Monica J.},
  title   = {{Heterogeneous expression of the triggering receptor expressed on myeloid cells‐2 on adult murine microglia}},
  journal = {Journal of Neurochemistry},
  year    = {2002},
  doi     = {10.1046/j.1471-4159.2002.01243.x},
  pmid    = {12472885},
  url     = {https://doi.org/10.1046/j.1471-4159.2002.01243.x}
}

@article{lee2002-12111820,
  author  = {Lee, Y. B. and Nagai, A. and Kim, S. U.},
  title   = {{Cytokines, chemokines, and cytokine receptors in human microglia}},
  journal = {Journal of neuroscience research},
  year    = {2002},
  doi     = {10.1002/jnr.10253},
  pmid    = {12111820},
  url     = {https://doi.org/10.1002/jnr.10253}
}

@article{lawrie2002-12062886,
  author  = {Lawrie, S. M. and Buechel, C. and Whalley, H. C. and Frith, C. D. and Friston, K. J. and Johnstone, E. C.},
  title   = {{Reduced frontotemporal functional connectivity in schizophrenia associated with auditory hallucinations}},
  journal = {Biological psychiatry},
  year    = {2002},
  doi     = {10.1016/s0006-3223(02)01316-1},
  pmid    = {12062886},
  url     = {https://doi.org/10.1016/s0006-3223(02)01316-1}
}

@article{teicher2002-12136507,
  author  = {Teicher, M. H. and Andersen, S. L. and Polcari, A. and Anderson, C. M. and Navalta, C. P.},
  title   = {{Developmental neurobiology of childhood stress and trauma}},
  journal = {The Psychiatric clinics of North America},
  year    = {2002},
  doi     = {10.1016/s0193-953x(01)00003-x},
  pmid    = {12136507},
  url     = {https://doi.org/10.1016/s0193-953x(01)00003-x}
}

@article{caparroslefebvre2002-11912113,
  author  = {Caparros-Lefebvre, D. and Sergeant, N. and Lees, A. and Camuzat, A. and Daniel, S. and Lannuzel, A. and Brice, A. and Tolosa, E. and others},
  title   = {{Guadeloupean parkinsonism: a cluster of progressive supranuclear palsy-like tauopathy}},
  journal = {Brain : a journal of neurology},
  year    = {2002},
  doi     = {10.1093/brain/awf086},
  pmid    = {11912113},
  url     = {https://doi.org/10.1093/brain/awf086}
}

@article{weidemann2002-11851430,
  author  = {Weidemann, A. and Eggert, S. and Reinhard, F. B. and Vogel, M. and Paliga, K. and Baier, G. and Masters, C. L. and Beyreuther, K. and others},
  title   = {{A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing}},
  journal = {Biochemistry},
  year    = {2002},
  doi     = {10.1021/bi015794o},
  pmid    = {11851430},
  url     = {https://doi.org/10.1021/bi015794o}
}

@article{gorry2001-11581376,
  author  = {Gorry, P. R. and Bristol, G. and Zack, J. A. and Ritola, K. and Swanstrom, R. and Birch, C. J. and Bell, J. E. and Bannert, N. and others},
  title   = {{Macrophage tropism of human immunodeficiency virus type 1 isolates from brain and lymphoid tissues predicts neurotropism independent of coreceptor specificity}},
  journal = {Journal of virology},
  year    = {2001},
  doi     = {10.1128/jvi.75.21.10073-10089.2001},
  pmid    = {11581376},
  url     = {https://doi.org/10.1128/jvi.75.21.10073-10089.2001}
}

@article{rosso2001-11571213,
  author  = {Rosso, S. M. and Kamphorst, W. and de Graaf, B. and Willemsen, R. and Ravid, R. and Niermeijer, M. F. and Spillantini, M. G. and Heutink, P. and others},
  title   = {{Familial frontotemporal dementia with ubiquitin-positive inclusions is linked to chromosome 17q21-22}},
  journal = {Brain : a journal of neurology},
  year    = {2001},
  doi     = {10.1093/brain/124.10.1948},
  pmid    = {11571213},
  url     = {https://doi.org/10.1093/brain/124.10.1948}
}

@article{rosenberg2001-11340226,
  author  = {Rosenberg, G. A. and Sullivan, N. and Esiri, M. M.},
  title   = {{White matter damage is associated with matrix metalloproteinases in vascular dementia}},
  journal = {Stroke},
  year    = {2001},
  doi     = {10.1161/01.str.32.5.1162},
  pmid    = {11340226},
  url     = {https://doi.org/10.1161/01.str.32.5.1162}
}

@article{erkan2000-11128669,
  author  = {Erkan, D. and Yazici, Y. and Sobel, R. and Lockshin, M. D.},
  title   = {{Primary antiphospholipid syndrome: functional outcome after 10 years}},
  journal = {The Journal of rheumatology},
  year    = {2000},
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  title   = {{Neurogranin in cerebrospinal fluid as a marker of synaptic dysfunction in hip fracture patients with delirium: a multicentre cross-sectional study}},
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  title   = {{The gain-of-function TREM2-T96K mutation increases risk for Alzheimer's disease by impairing microglial function}},
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  title   = {{Circulating Brain-Related miRNAs as Predictors of Postoperative Delirium in Cardiac Surgery Patients}},
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}

@article{sandhu2025-40753006,
  author  = {Sandhu, Gurveen Kaur and Vipin, Ashwati and Leonardo, Jacklyn and Zailan, Fatin Zahra and Tanoto, Pricilia and Lee, Faith Phemie Hui En and Sim, Xin Ying and Ghildiyal, Smriti and others},
  title   = {{The role of Tau, amyloid-β and neuroinflammation in the association between cognition and white matter hyperintensities in a southeast Asian cohort}},
  journal = {The Journal of Prevention of Alzheimer s Disease},
  year    = {2025},
  doi     = {10.1016/j.tjpad.2025.100300},
  pmid    = {40753006},
  url     = {https://doi.org/10.1016/j.tjpad.2025.100300}
}

@article{tabassum2025-40860138,
  author  = {Tabassum, Nishat I and Selvaraji, Sharmelee and Fan, Yibo and Lim, Vernise J.T. and Cheng, Xiangru and Peng, Xiangyuan and Arora, Aayushi and Rajeev, Vismitha and others},
  title   = {{Intermittent fasting reprograms the brain proteome to prevent synaptic degeneration and cognitive impairment in vascular dementia}},
  journal = {Theranostics},
  year    = {2025},
  doi     = {10.7150/thno.119422},
  pmid    = {40860138},
  url     = {https://doi.org/10.7150/thno.119422}
}

@article{hou2025-40707828,
  author  = {Hou, Jia‐Hui and Chu, Min Kyung and Chen, Zhongyun and Jiang, Deming and Chen, Yufei Andy and Yue, Ailing and He, Qianqian and Lu, Hua Rong and others},
  title   = {{Interaction of metabolic and inflammatory dysregulation on central degeneration and cognitive function in behavioral variant Frontotemporal dementia}},
  journal = {Journal of Neurology},
  year    = {2025},
  doi     = {10.1007/s00415-025-13268-w},
  pmid    = {40707828},
  url     = {https://doi.org/10.1007/s00415-025-13268-w}
}

@article{murakami2025-40635087,
  author  = {Murakami, Aya and Koga, Shunsuke and Sekiya, Hiroaki and Nakamura, Masataka and Yakushiji, Yusuke and Dickson, Dennis W.},
  title   = {{Frontotemporal Lobar degeneration with TDP-43 presenting as progressive supranuclear palsy syndrome}},
  journal = {Acta Neuropathologica Communications},
  year    = {2025},
  doi     = {10.1186/s40478-025-02058-0},
  pmid    = {40635087},
  url     = {https://doi.org/10.1186/s40478-025-02058-0}
}

@article{bouzigues2025-40673371,
  author  = {Bouzigues, Arabella and Le Du, Vincent and Joulot, Matthieu and Peysson, Ninon and Houot, Marion and Béranger, Benoît and Russell, Lucy Louise and Foster, Phoebe H. and others},
  title   = {{Structural and functional connectivity in tau mutation carriers: from presymptomatic to symptomatic frontotemporal dementia}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz.70367},
  pmid    = {40673371},
  url     = {https://doi.org/10.1002/alz.70367}
}

@article{kannarkat2025-40521808,
  author  = {Kannarkat, George T. and Zack, Rebecca and Skrinak, R. Tyler and Morley, James F. and Davila‐Rivera, Roseanne and Arezoumandan, Sanaz and Dorfman, Katherine A. and Luk, Kelvin C. and others},
  title   = {{Blood α‐Synuclein Separates Parkinson's Disease from Dementia with Lewy Bodies}},
  journal = {Annals of Neurology},
  year    = {2025},
  doi     = {10.1002/ana.27288},
  pmid    = {40521808},
  url     = {https://doi.org/10.1002/ana.27288}
}

@article{wang2025-40497513,
  author  = {Wang, Youjie and Wang, Ruilin and Wang, Hang and Cao, Le and Ye, Chen and Liu, Junfeng and Wu, Bo and Kwapong, William Robert and others},
  title   = {{Choroidal Vascular Volume, White Matter Hyperintensity, and Their Interaction With Cognitive Function in Aging Adults}},
  journal = {Journal of the American Heart Association},
  year    = {2025},
  doi     = {10.1161/jaha.124.039369},
  pmid    = {40497513},
  url     = {https://doi.org/10.1161/jaha.124.039369}
}

@article{chen2025-40349252,
  author  = {Chen, Jia‐Hung and Chan, Lung and Hong, Chien‐Tai and Hu, Chaur Jong and Hsieh, Yi‐Chen},
  title   = {{Role of apolipoprotein E (ApoE) ε4 in cognitive impairment after a stroke: a prospective cohort study}},
  journal = {Aging},
  year    = {2025},
  doi     = {10.18632/aging.206248},
  pmid    = {40349252},
  url     = {https://doi.org/10.18632/aging.206248}
}

@article{verde2025-40422183,
  author  = {Verde, Enza Maria and Secco, Valentina and Ghezzi, Andrea and Mandrioli, Jessica and Carra, Serena},
  title   = {{Molecular Mechanisms of Protein Aggregation in ALS-FTD: Focus on TDP-43 and Cellular Protective Responses}},
  journal = {Cells},
  year    = {2025},
  doi     = {10.3390/cells14100680},
  pmid    = {40422183},
  url     = {https://doi.org/10.3390/cells14100680}
}

@article{martiskainen2025-40301889,
  author  = {Martiskainen, Henna and Willman, Roosa-Maria and Harju, Päivi and Heikkinen, Sami V. and Heiskanen, Mette and Müller, Stephan A. and Sinisalo, Rosa and Takalo, Mari and others},
  title   = {{Monoallelic TYROBP deletion is a novel risk factor for Alzheimer’s disease}},
  journal = {Molecular Neurodegeneration},
  year    = {2025},
  doi     = {10.1186/s13024-025-00830-3},
  pmid    = {40301889},
  url     = {https://doi.org/10.1186/s13024-025-00830-3}
}

@article{sawada2025-40567454,
  author  = {Sawada, Yoichi and Satoh, Toru and Saba, Hideaki and Kato, Yoshiki and Kuwada, Tomoko and Shima, Sayoko and Murakami, Kana and Sasaki, Megumi and others},
  title   = {{Assessment of localized brain regions correlated with MMSE using VBM analysis of structural MRI in a Japanese sample}},
  journal = {Neuroimage Reports},
  year    = {2025},
  doi     = {10.1016/j.ynirp.2025.100264},
  pmid    = {40567454},
  url     = {https://doi.org/10.1016/j.ynirp.2025.100264}
}

@article{altahrawi2025-40277934,
  author  = {Altahrawi, Aseel Y. and James, Antonisamy William and Shah, Zahoor Ahmad},
  title   = {{The Role of Oxidative Stress and Inflammation in the Pathogenesis and Treatment of Vascular Dementia}},
  journal = {Cells},
  year    = {2025},
  doi     = {10.3390/cells14080609},
  pmid    = {40277934},
  url     = {https://doi.org/10.3390/cells14080609}
}

@article{wright2025-40267731,
  author  = {Wright, Laura and Donaghy, Paul C. and Burn, David John and Taylor, John‐Paul and O'Brien, John Tiernan and Yarnall, Alison Jane and Matthews, Fiona E. and Firbank, Michael John and others},
  title   = {{Brain network connectivity underlying neuropsychiatric symptoms in prodromal Lewy body dementia}},
  journal = {Neurobiology of Aging},
  year    = {2025},
  doi     = {10.1016/j.neurobiolaging.2025.04.007},
  pmid    = {40267731},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2025.04.007}
}

@article{ashok2025-40238886,
  author  = {Ashok, Cheemala and Kimble, Amy L. and Burrage, Emily Nicole and Helming, Stephen B. and Tyburski, Jordan D. and Leclair, Nathan K. and Omar, Omar M. and Zuberi, Aamir R. and others},
  title   = {{Amyotrophic lateral sclerosis and frontotemporal dementia mutation reduces endothelial TDP-43 and causes blood-brain barrier defects}},
  journal = {Science Advances},
  year    = {2025},
  doi     = {10.1126/sciadv.ads0505},
  pmid    = {40238886},
  url     = {https://doi.org/10.1126/sciadv.ads0505}
}

@article{yagi2025-40143815,
  author  = {Yagi, Hitomi and Boeck, Myriam and Neilsen, Katherine and Yang, Jay and Ko, Minji and Tomita, Yohei and Negishi, Kazuno and Fu, Zhongjie and others},
  title   = {{Choroidal Neovascularization Is Suppressed With Activation of TREM2 in Mononuclear Phagocytes—Brief Report}},
  journal = {Arteriosclerosis Thrombosis and Vascular Biology},
  year    = {2025},
  doi     = {10.1161/atvbaha.124.321809},
  pmid    = {40143815},
  url     = {https://doi.org/10.1161/atvbaha.124.321809}
}

@article{mitra2025-40057796,
  author  = {Mitra, Joy and Kodavati, Manohar M. and Dharmalingam, Prakash and Guerrero, Erika N. and Rao, K. S. Jagannatha and Garruto, Ralph M. and Hegde, Muralidhar L.},
  title   = {{Endogenous TDP-43 mislocalization in a novel knock-in mouse model reveals DNA repair impairment, inflammation, and neuronal senescence}},
  journal = {Acta Neuropathologica Communications},
  year    = {2025},
  doi     = {10.1186/s40478-025-01962-9},
  pmid    = {40057796},
  url     = {https://doi.org/10.1186/s40478-025-01962-9}
}

@article{liao2025-40047555,
  author  = {Liao, Y. and Chong, JR. and Kan, C. N. and Zhao, X. and Chai, Y. L. and Hilal, S. and Lai, M. K. P. and Chen, C. P. and others},
  title   = {{Plasma NfL, P-tau181, and P-tau181/Aβ42 Ratio in Predicting Mild Behavioral Impairment in Dementia-Free Multiethnic Asian Older Adults With Mixed Pathology in a 5-Year Clinical Cohort}},
  journal = {The Journal of clinical psychiatry},
  year    = {2025},
  doi     = {10.4088/jcp.24m15558},
  pmid    = {40047555},
  url     = {https://doi.org/10.4088/jcp.24m15558}
}

@article{park2025-39924830,
  author  = {Park, Chang-Hyun and Lee, Hyunji and Lee, Young Min and Lee, Byung Dae and Moon, Eunsoo and Suh, Hwagyu and Kim, Kyungwon and Kim, Hak Jin and others},
  title   = {{Sex-specific effects of apolipoprotein E ε4 genotype on longitudinal hippocampal atrophy in amnestic mild cognitive impairment over a 2-year evaluation period}},
  journal = {Journal of Alzheimer s Disease},
  year    = {2025},
  doi     = {10.1177/13872877241313066},
  pmid    = {39924830},
  url     = {https://doi.org/10.1177/13872877241313066}
}

@article{ye2025-39806423,
  author  = {Ye, Jinwang and Zhong, Suyue and Wan, Huali and Guo, Xing and Yao, Xuanbao and Liu, Qiong and Chen, Liming and Wang, Jian‐Zhi and others},
  title   = {{Upregulated astrocyte HDAC7 induces Alzheimer-like tau pathologies via deacetylating transcription factor-EB and inhibiting lysosome biogenesis}},
  journal = {Molecular Neurodegeneration},
  year    = {2025},
  doi     = {10.1186/s13024-025-00796-2},
  pmid    = {39806423},
  url     = {https://doi.org/10.1186/s13024-025-00796-2}
}

@article{leckey2025-41416248,
  author  = {Leckey, Claire Alexandra and Giovannucci, Tatiana A. and Coulton, John B. and He, Yingxin and Sato, Chihiro and Ghoshal, Nupur and Vignarajah, Tharini and Jaunmuktane, Zane and others},
  title   = {{Stable isotope labelling kinetics of neurofilament light}},
  journal = {Brain Communications},
  year    = {2025},
  doi     = {10.1093/braincomms/fcaf468},
  pmid    = {41416248},
  url     = {https://doi.org/10.1093/braincomms/fcaf468}
}

@article{morato2024-39640195,
  author  = {Morató, X. and Puerta, R. and Cano, A. and Orellana, A. and de Rojas, I. and Capdevila, M. and Montrreal, L. and Rosende-Roca, M. and others},
  title   = {{Associations of plasma SMOC1 and soluble IL6RA levels with the progression from mild cognitive impairment to dementia}},
  journal = {Brain, behavior, \& immunity - health},
  year    = {2024},
  doi     = {10.1016/j.bbih.2024.100899},
  pmid    = {39640195},
  url     = {https://doi.org/10.1016/j.bbih.2024.100899}
}

@article{gunaydin2024-39511891,
  author  = {Günaydin, C. and Sondhi, D. and Kaminsky, S. M. and Lephart, H. C. and Leopold, P. L. and Hackett, N. R. and Khanna, R. and Crystal, R. G.},
  title   = {{AAVrh.10 delivery of novel APOE2-Christchurch variant suppresses amyloid and Tau pathology in Alzheimer's disease mice}},
  journal = {Molecular Therapy},
  year    = {2024},
  doi     = {10.1016/j.ymthe.2024.11.003},
  pmid    = {39511891},
  url     = {https://doi.org/10.1016/j.ymthe.2024.11.003}
}

@article{zhang2025-39193909,
  author  = {Zhang, Z. and Chen, S. and Jun, S. and Xu, X. and Hong, Y. and Yang, X. and Zou, L. and Song, Y. Q. and others},
  title   = {{MLKL-USP7-UBA52 signaling is indispensable for autophagy in brain through maintaining ubiquitin homeostasis}},
  journal = {Autophagy},
  year    = {2025},
  doi     = {10.1080/15548627.2024.2395727},
  pmid    = {39193909},
  url     = {https://doi.org/10.1080/15548627.2024.2395727}
}

@article{prevot2023-37261390,
  author  = {Prévot, V. and Tena-Sempere, M. and Pitteloud, N.},
  title   = {{New Horizons: Gonadotropin-Releasing Hormone and Cognition}},
  journal = {The Journal of clinical endocrinology and metabolism},
  year    = {2023},
  doi     = {10.1210/clinem/dgad319},
  pmid    = {37261390},
  url     = {https://doi.org/10.1210/clinem/dgad319}
}

@article{xu2023-36829205,
  author  = {Xu, J. and Zhang, L. and Li, M. and He, X. and Luo, J. and Wu, R. and Hong, Z. and Zheng, H. and others},
  title   = {{TREM2 mediates physical exercise-promoted neural functional recovery in rats with ischemic stroke via microglia-promoted white matter repair}},
  journal = {Journal of neuroinflammation},
  year    = {2023},
  doi     = {10.1186/s12974-023-02741-w},
  pmid    = {36829205},
  url     = {https://doi.org/10.1186/s12974-023-02741-w}
}

@article{tran2023-36803190,
  author  = {Tran, K. M. and Kawauchi, S. and Kramár, E. A. and Rezaie, N. and Liang, H. Y. and Sakr, J. S. and Gomez-Arboledas, A. and Arreola, M. A. and others},
  title   = {{A Trem2R47H mouse model without cryptic splicing drives age- and disease-dependent tissue damage and synaptic loss in response to plaques}},
  journal = {Molecular neurodegeneration},
  year    = {2023},
  doi     = {10.1186/s13024-023-00598-4},
  pmid    = {36803190},
  url     = {https://doi.org/10.1186/s13024-023-00598-4}
}

@article{peng2023-36662361,
  author  = {Peng, X. and Guo, H. and Zhang, X. and Yang, Z. and Ruganzu, J. B. and Wu, X. and Bi, W. and others},
  title   = {{TREM2 Inhibits Tau Hyperphosphorylation and Neuronal Apoptosis via the PI3K/Akt/GSK-3β Signaling Pathway In vivo and In vitro}},
  journal = {Molecular neurobiology},
  year    = {2023},
  doi     = {10.1007/s12035-023-03217-x},
  pmid    = {36662361},
  url     = {https://doi.org/10.1007/s12035-023-03217-x}
}

@article{church2022-36517889,
  author  = {Church, K. A. and Rodriguez, D. and Vanegas, D. and Gutierrez, I. L. and Cardona, S. M. and Madrigal, J. L. M. and Kaur, T. and Cardona, A. E.},
  title   = {{Models of microglia depletion and replenishment elicit protective effects to alleviate vascular and neuronal damage in the diabetic murine retina}},
  journal = {Journal of neuroinflammation},
  year    = {2022},
  doi     = {10.1186/s12974-022-02659-9},
  pmid    = {36517889},
  url     = {https://doi.org/10.1186/s12974-022-02659-9}
}

@article{khantakova2022-35746551,
  author  = {Khantakova, D. and Brioschi, S. and Molgora, M.},
  title   = {{Exploring the Impact of TREM2 in Tumor-Associated Macrophages}},
  journal = {Vaccines},
  year    = {2022},
  doi     = {10.3390/vaccines10060943},
  pmid    = {35746551},
  url     = {https://doi.org/10.3390/vaccines10060943}
}

@article{sanjay2022-35670898,
  author  = {Sanjay and Shin, J. H. and Park, M. and Lee, H. J.},
  title   = {{Cyanidin-3-O-Glucoside Regulates the M1/M2 Polarization of Microglia via PPARγ and Aβ42 Phagocytosis Through TREM2 in an Alzheimer's Disease Model}},
  journal = {Molecular neurobiology},
  year    = {2022},
  doi     = {10.1007/s12035-022-02873-9},
  pmid    = {35670898},
  url     = {https://doi.org/10.1007/s12035-022-02873-9}
}

@article{strain2022-35358703,
  author  = {Strain, J. F. and Barthelemy, N. and Horie, K. and Gordon, B. A. and Kilgore, C. and Aschenbrenner, A. and Cruchaga, C. and Xiong, C. and others},
  title   = {{CSF Tau phosphorylation at Thr205 is associated with loss of white matter integrity in autosomal dominant Alzheimer disease}},
  journal = {Neurobiology of disease},
  year    = {2022},
  doi     = {10.1016/j.nbd.2022.105714},
  pmid    = {35358703},
  url     = {https://doi.org/10.1016/j.nbd.2022.105714}
}

@article{anad2022-35086142,
  author  = {Anad, A. and Barker, M. K. and Katanga, J. A. and Arfanakis, K. and Bridges, L. R. and Esiri, M. M. and Isaacs, J. D. and Prpar Mihevc, S. and others},
  title   = {{Vasculocentric Axonal NfH in Small Vessel Disease}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2022},
  doi     = {10.1093/jnen/nlab134},
  pmid    = {35086142},
  url     = {https://doi.org/10.1093/jnen/nlab134}
}

@article{song2022-35017668,
  author  = {Song, S. and Yu, L. and Hasan, M. N. and Paruchuri, S. S. and Mullett, S. J. and Sullivan, M. L. G. and Fiesler, V. M. and Young, C. B. and others},
  title   = {{Elevated microglial oxidative phosphorylation and phagocytosis stimulate post-stroke brain remodeling and cognitive function recovery in mice}},
  journal = {Communications biology},
  year    = {2022},
  doi     = {10.1038/s42003-021-02984-4},
  pmid    = {35017668},
  url     = {https://doi.org/10.1038/s42003-021-02984-4}
}

@article{lee2021-34965428,
  author  = {Lee, S. H. and Rezzonico, M. G. and Friedman, B. A. and Huntley, M. H. and Meilandt, W. J. and Pandey, S. and Chen, Y. J. and Easton, A. and others},
  title   = {{TREM2-independent oligodendrocyte, astrocyte, and T cell responses to tau and amyloid pathology in mouse models of Alzheimer disease}},
  journal = {Cell reports},
  year    = {2021},
  doi     = {10.1016/j.celrep.2021.110158},
  pmid    = {34965428},
  url     = {https://doi.org/10.1016/j.celrep.2021.110158}
}

@article{lichtenthaler2022-34689040,
  author  = {Lichtenthaler, S. F. and Tschirner, S. K. and Steiner, H.},
  title   = {{Secretases in Alzheimer's disease: Novel insights into proteolysis of APP and TREM2}},
  journal = {Current opinion in neurobiology},
  year    = {2022},
  doi     = {10.1016/j.conb.2021.09.003},
  pmid    = {34689040},
  url     = {https://doi.org/10.1016/j.conb.2021.09.003}
}

@article{zwirner2021-34114049,
  author  = {Zwirner, J. and Lier, J. and Franke, H. and Hammer, N. and Matschke, J. and Trautz, F. and Tse, R. and Ondruschka, B.},
  title   = {{GFAP positivity in neurons following traumatic brain injuries}},
  journal = {International journal of legal medicine},
  year    = {2021},
  doi     = {10.1007/s00414-021-02568-1},
  pmid    = {34114049},
  url     = {https://doi.org/10.1007/s00414-021-02568-1}
}

@article{chen2021-33729626,
  author  = {Chen, M. J. and Ramesha, S. and Weinstock, L. D. and Gao, T. and Ping, L. and Xiao, H. and Dammer, E. B. and Duong, D. D. and others},
  title   = {{Extracellular signal-regulated kinase regulates microglial immune responses in Alzheimer's disease}},
  journal = {Journal of neuroscience research},
  year    = {2021},
  doi     = {10.1002/jnr.24829},
  pmid    = {33729626},
  url     = {https://doi.org/10.1002/jnr.24829}
}

@article{cheng2021-33679809,
  author  = {Cheng, X. and Wang, X. and Nie, K. and Cheng, L. and Zhang, Z. and Hu, Y. and Peng, W.},
  title   = {{Systematic Pan-Cancer Analysis Identifies TREM2 as an Immunological and Prognostic Biomarker}},
  journal = {Frontiers in immunology},
  year    = {2021},
  doi     = {10.3389/fimmu.2021.646523},
  pmid    = {33679809},
  url     = {https://doi.org/10.3389/fimmu.2021.646523}
}

@article{reich2020-33613545,
  author  = {Reich, M. and Paris, I. and Ebeling, M. and Dahm, N. and Schweitzer, C. and Reinhardt, D. and Schmucki, R. and Prasad, M. and others},
  title   = {{Alzheimer's Risk Gene TREM2 Determines Functional Properties of New Type of Human iPSC-Derived Microglia}},
  journal = {Frontiers in immunology},
  year    = {2020},
  doi     = {10.3389/fimmu.2020.617860},
  pmid    = {33613545},
  url     = {https://doi.org/10.3389/fimmu.2020.617860}
}

@article{ruganzu2021-33065077,
  author  = {Ruganzu, J. B. and Zheng, Q. and Wu, X. and He, Y. and Peng, X. and Jin, H. and Zhou, J. and Ma, R. and others},
  title   = {{TREM2 overexpression rescues cognitive deficits in APP/PS1 transgenic mice by reducing neuroinflammation via the JAK/STAT/SOCS signaling pathway}},
  journal = {Experimental neurology},
  year    = {2021},
  doi     = {10.1016/j.expneurol.2020.113506},
  pmid    = {33065077},
  url     = {https://doi.org/10.1016/j.expneurol.2020.113506}
}

@article{luningham2020-32961112,
  author  = {Luningham, J. M. and Chen, J. and Tang, S. and De Jager, P. L. and Bennett, D. A. and Buchman, A. S. and Yang, J.},
  title   = {{Bayesian Genome-wide TWAS Method to Leverage both cis- and trans-eQTL Information through Summary Statistics}},
  journal = {American journal of human genetics},
  year    = {2020},
  doi     = {10.1016/j.ajhg.2020.08.022},
  pmid    = {32961112},
  url     = {https://doi.org/10.1016/j.ajhg.2020.08.022}
}

@article{lanzillotta2021-32795489,
  author  = {Lanzillotta, C. and Zuliani, I. and Tramutola, A. and Barone, E. and Blarzino, C. and Folgiero, V. and Caforio, M. and Valentini, D. and others},
  title   = {{Chronic PERK induction promotes Alzheimer-like neuropathology in Down syndrome: Insights for therapeutic intervention}},
  journal = {Progress in neurobiology},
  year    = {2021},
  doi     = {10.1016/j.pneurobio.2020.101892},
  pmid    = {32795489},
  url     = {https://doi.org/10.1016/j.pneurobio.2020.101892}
}

@article{fitz2020-32703241,
  author  = {Fitz, N. F. and Wolfe, C. M. and Playso, B. E. and Biedrzycki, R. J. and Lu, Y. and Nam, K. N. and Lefterov, I. and Koldamova, R.},
  title   = {{Trem2 deficiency differentially affects phenotype and transcriptome of human APOE3 and APOE4 mice}},
  journal = {Molecular neurodegeneration},
  year    = {2020},
  doi     = {10.1186/s13024-020-00394-4},
  pmid    = {32703241},
  url     = {https://doi.org/10.1186/s13024-020-00394-4}
}

@article{harada2021-32646880,
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  title   = {{Microglia influence host defense, disease, and repair following murine coronavirus infection of the central nervous system}},
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  title   = {{Convergence between Microglia and Peripheral Macrophages Phenotype during Development and Neuroinflammation}},
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  title   = {{Exercise and metformin counteract altered mitochondrial function in the insulin-resistant brain}},
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  year    = {2019},
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  title   = {{TREM2 is required for microglial instruction of astrocytic synaptic engulfment in neurodevelopment}},
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@article{baldacci2019-31195846,
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  title   = {{The neuroinflammatory biomarker YKL-40 for neurodegenerative diseases: advances in development}},
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@article{wani2019-30894052,
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  title   = {{Alborixin clears amyloid-β by inducing autophagy through PTEN-mediated inhibition of the AKT pathway}},
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@article{goedert2019-32096024,
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  year    = {2019},
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  title   = {{Triggering receptor expressed on myeloid cells-2 expression in the brain is required for maximal phagocytic activity and improved neurological outcomes following experimental stroke}},
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  year    = {2019},
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@article{ovchinnikov2018-29861166,
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  title   = {{The Impact of APP on Alzheimer-like Pathogenesis and Gene Expression in Down Syndrome iPSC-Derived Neurons}},
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@article{garciaesparcia2018-29755340,
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  title   = {{Glutamate Transporter GLT1 Expression in Alzheimer Disease and Dementia With Lewy Bodies}},
  journal = {Frontiers in aging neuroscience},
  year    = {2018},
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@article{zhang2018-29621548,
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  title   = {{TREM2 modulates microglia phenotypes in the neuroinflammation of Parkinson's disease}},
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  year    = {2018},
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  title   = {{Blood-Brain Barrier Dysfunction Precedes Cognitive Decline and Neurodegeneration in Diabetic Insulin Resistant Mouse Model: An Implication for Causal Link}},
  journal = {Frontiers in aging neuroscience},
  year    = {2017},
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  pmid    = {29249964},
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@article{zhong2017-28680398,
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  title   = {{TREM2/DAP12 Complex Regulates Inflammatory Responses in Microglia via the JNK Signaling Pathway}},
  journal = {Frontiers in aging neuroscience},
  year    = {2017},
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@article{vanosch2018-28598243,
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  title   = {{Advances in arterial spin labelling MRI methods for measuring perfusion and collateral flow}},
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  year    = {2018},
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@article{wyatt2017-28601603,
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  title   = {{Enhanced classical complement pathway activation and altered phagocytosis signaling molecules in human epilepsy}},
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  year    = {2017},
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  pmid    = {28601603},
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@article{colomcadena2017-28395086,
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  title   = {{Regional Overlap of Pathologies in Lewy Body Disorders}},
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  title   = {{Pharmacokinetic Evaluation of the Tau PET Radiotracer 18F-T807 (18F-AV-1451) in Human Subjects}},
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  title   = {{Rare TREM2 variants associated with Alzheimer's disease display reduced cell surface expression}},
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  year    = {2016},
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@article{festoff2016-27553758,
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  title   = {{HMGB1 and thrombin mediate the blood-brain barrier dysfunction acting as biomarkers of neuroinflammation and progression to neurodegeneration in Alzheimer's disease}},
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@article{tsai2016-27318702,
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@article{ahmad2016-27211305,
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  title   = {{Human TBK1: A Gatekeeper of Neuroinflammation}},
  journal = {Trends in molecular medicine},
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@article{du2017-27206432,
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  title   = {{Molecular Mechanisms of Vascular Dementia: What Can Be Learned from Animal Models of Chronic Cerebral Hypoperfusion?}},
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@article{saber2017-26976047,
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  title   = {{Triggering Receptor Expressed on Myeloid Cells 2 Deficiency Alters Acute Macrophage Distribution and Improves Recovery after Traumatic Brain Injury}},
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  title   = {{TREM2 upregulation correlates with 5-hydroxymethycytosine enrichment in Alzheimer's disease hippocampus}},
  journal = {Clinical epigenetics},
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  title   = {{Combined Liver X Receptor/Peroxisome Proliferator-activated Receptor γ Agonist Treatment Reduces Amyloid β Levels and Improves Behavior in Amyloid Precursor Protein/Presenilin 1 Mice}},
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  title   = {{Dynamic changes in pro- and anti-inflammatory cytokines in microglia after PPAR-γ agonist neuroprotective treatment in the MPTPp mouse model of progressive Parkinson's disease}},
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  title   = {{mTOR Hyperactivation in down syndrome hippocampus appears early during development}},
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  year    = {2014},
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  title   = {{Intermittent fasting attenuates lipopolysaccharide-induced neuroinflammation and memory impairment}},
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  year    = {2014},
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  title   = {{Phosphorylation of tau protein at sites Ser(396-404) is one of the earliest events in Alzheimer's disease and Down syndrome}},
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  year    = {2014},
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  title   = {{Amyloid precursor protein controls cholesterol turnover needed for neuronal activity}},
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  title   = {{Mesenchymal stem cells enhance autophagy and increase β-amyloid clearance in Alzheimer disease models}},
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  title   = {{Recurrent mutations in DNAJC5 cause autosomal dominant Kufs disease}},
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@article{haining2012-23035126,
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  title   = {{The TspanC8 subgroup of tetraspanins interacts with A disintegrin and metalloprotease 10 (ADAM10) and regulates its maturation and cell surface expression}},
  journal = {The Journal of biological chemistry},
  year    = {2012},
  doi     = {10.1074/jbc.m112.416503},
  pmid    = {23035126},
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}

@article{leroy2012-23026200,
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  title   = {{Lack of tau proteins rescues neuronal cell death and decreases amyloidogenic processing of APP in APP/PS1 mice}},
  journal = {The American journal of pathology},
  year    = {2012},
  doi     = {10.1016/j.ajpath.2012.08.012},
  pmid    = {23026200},
  url     = {https://doi.org/10.1016/j.ajpath.2012.08.012}
}

@article{iannaccone2013-22841687,
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  title   = {{In vivo microglia activation in very early dementia with Lewy bodies, comparison with Parkinson's disease}},
  journal = {Parkinsonism \& related disorders},
  year    = {2013},
  doi     = {10.1016/j.parkreldis.2012.07.002},
  pmid    = {22841687},
  url     = {https://doi.org/10.1016/j.parkreldis.2012.07.002}
}

@article{xie2012-22776459,
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  title   = {{Abnormal insula functional network is associated with episodic memory decline in amnestic mild cognitive impairment}},
  journal = {NeuroImage},
  year    = {2012},
  doi     = {10.1016/j.neuroimage.2012.06.062},
  pmid    = {22776459},
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}

@article{winkler2012-22532566,
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  title   = {{Generation of Alzheimer disease-associated amyloid β42/43 peptide by γ-secretase can be inhibited directly by modulation of membrane thickness}},
  journal = {The Journal of biological chemistry},
  year    = {2012},
  doi     = {10.1074/jbc.m112.356659},
  pmid    = {22532566},
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}

@article{ash2012-22099969,
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  title   = {{Impairments of speech fluency in Lewy body spectrum disorder}},
  journal = {Brain and language},
  year    = {2012},
  doi     = {10.1016/j.bandl.2011.09.004},
  pmid    = {22099969},
  url     = {https://doi.org/10.1016/j.bandl.2011.09.004}
}

@article{fang2012-22015470,
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  title   = {{Multi-faced neuroprotective effects of Ginsenoside Rg1 in an Alzheimer mouse model}},
  journal = {Biochimica et biophysica acta},
  year    = {2012},
  doi     = {10.1016/j.bbadis.2011.10.004},
  pmid    = {22015470},
  url     = {https://doi.org/10.1016/j.bbadis.2011.10.004}
}

@article{bohnen2011-21343896,
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  title   = {{White matter lesions in Parkinson disease}},
  journal = {Nature reviews. Neurology},
  year    = {2011},
  doi     = {10.1038/nrneurol.2011.21},
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}

@article{caccamo2011-21266573,
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  title   = {{Naturally secreted amyloid-beta increases mammalian target of rapamycin (mTOR) activity via a PRAS40-mediated mechanism}},
  journal = {The Journal of biological chemistry},
  year    = {2011},
  doi     = {10.1074/jbc.m110.180638},
  pmid    = {21266573},
  url     = {https://doi.org/10.1074/jbc.m110.180638}
}

@article{delarasse2011-21081501,
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  title   = {{The purinergic receptor P2X7 triggers alpha-secretase-dependent processing of the amyloid precursor protein}},
  journal = {The Journal of biological chemistry},
  year    = {2011},
  doi     = {10.1074/jbc.m110.200618},
  pmid    = {21081501},
  url     = {https://doi.org/10.1074/jbc.m110.200618}
}

@article{thanopoulou2010-21076037,
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  title   = {{Scavenger receptor class B type I (SR-BI) regulates perivascular macrophages and modifies amyloid pathology in an Alzheimer mouse model}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2010},
  doi     = {10.1073/pnas.1005888107},
  pmid    = {21076037},
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}

@article{wan2011-21034809,
  author  = {Wan, L. and Nie, G. and Zhang, J. and Luo, Y. and Zhang, P. and Zhang, Z. and Zhao, B.},
  title   = {{β-Amyloid peptide increases levels of iron content and oxidative stress in human cell and Caenorhabditis elegans models of Alzheimer disease}},
  journal = {Free radical biology \& medicine},
  year    = {2011},
  doi     = {10.1016/j.freeradbiomed.2010.10.707},
  pmid    = {21034809},
  url     = {https://doi.org/10.1016/j.freeradbiomed.2010.10.707}
}

@article{kitazume2010-20952385,
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  title   = {{Brain endothelial cells produce amyloid beta from amyloid precursor protein 770 and preferentially secrete the O-glycosylated form}},
  journal = {The Journal of biological chemistry},
  year    = {2010},
  doi     = {10.1074/jbc.m110.144626},
  pmid    = {20952385},
  url     = {https://doi.org/10.1074/jbc.m110.144626}
}

@article{forlenza2010-20491609,
  author  = {Forlenza, O. V. and Diniz, B. S. and Teixeira, A. L. and Ojopi, E. B. and Talib, L. L. and Mendonça, V. A. and Izzo, G. and Gattaz, W. F.},
  title   = {{Effect of brain-derived neurotrophic factor Val66Met polymorphism and serum levels on the progression of mild cognitive impairment}},
  journal = {The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry},
  year    = {2010},
  doi     = {10.3109/15622971003797241},
  pmid    = {20491609},
  url     = {https://doi.org/10.3109/15622971003797241}
}

@article{shinohara2010-20472556,
  author  = {Shinohara, M. and Sato, N. and Kurinami, H. and Takeuchi, D. and Takeda, S. and Shimamura, M. and Yamashita, T. and Uchiyama, Y. and others},
  title   = {{Reduction of brain beta-amyloid (Abeta) by fluvastatin, a hydroxymethylglutaryl-CoA reductase inhibitor, through increase in degradation of amyloid precursor protein C-terminal fragments (APP-CTFs) and Abeta clearance}},
  journal = {The Journal of biological chemistry},
  year    = {2010},
  doi     = {10.1074/jbc.m110.102277},
  pmid    = {20472556},
  url     = {https://doi.org/10.1074/jbc.m110.102277}
}

@article{vilardo2010-20395292,
  author  = {Vilardo, E. and Barbato, C. and Ciotti, M. and Cogoni, C. and Ruberti, F.},
  title   = {{MicroRNA-101 regulates amyloid precursor protein expression in hippocampal neurons}},
  journal = {The Journal of biological chemistry},
  year    = {2010},
  doi     = {10.1074/jbc.m110.112664},
  pmid    = {20395292},
  url     = {https://doi.org/10.1074/jbc.m110.112664}
}

@article{sultana2010-19686046,
  author  = {Sultana, R. and Perluigi, M. and Newman, S. F. and Pierce, W. M. and Cini, C. and Coccia, R. and Butterfield, D. A.},
  title   = {{Redox proteomic analysis of carbonylated brain proteins in mild cognitive impairment and early Alzheimer's disease}},
  journal = {Antioxidants \& redox signaling},
  year    = {2010},
  doi     = {10.1089/ars.2009.2810},
  pmid    = {19686046},
  url     = {https://doi.org/10.1089/ars.2009.2810}
}

@article{sultana2010-19774677,
  author  = {Sultana, R. and Banks, W. A. and Butterfield, D. A.},
  title   = {{Decreased levels of PSD95 and two associated proteins and increased levels of BCl2 and caspase 3 in hippocampus from subjects with amnestic mild cognitive impairment: Insights into their potential roles for loss of synapses and memory, accumulation of Abeta, and neurodegeneration in a prodromal stage of Alzheimer's disease}},
  journal = {Journal of neuroscience research},
  year    = {2010},
  doi     = {10.1002/jnr.22227},
  pmid    = {19774677},
  url     = {https://doi.org/10.1002/jnr.22227}
}

@article{durakoglugil2009-19805234,
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  title   = {{Reelin signaling antagonizes beta-amyloid at the synapse}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2009},
  doi     = {10.1073/pnas.0908176106},
  pmid    = {19805234},
  url     = {https://doi.org/10.1073/pnas.0908176106}
}

@article{rossi2009-19631259,
  author  = {Rossi, D. and Volterra, A.},
  title   = {{Astrocytic dysfunction: insights on the role in neurodegeneration}},
  journal = {Brain research bulletin},
  year    = {2009},
  doi     = {10.1016/j.brainresbull.2009.07.012},
  pmid    = {19631259},
  url     = {https://doi.org/10.1016/j.brainresbull.2009.07.012}
}

@article{yokota2009-19194716,
  author  = {Yokota, O. and Tsuchiya, K. and Arai, T. and Yagishita, S. and Matsubara, O. and Mochizuki, A. and Tamaoka, A. and Kawamura, M. and others},
  title   = {{Clinicopathological characterization of Pick's disease versus frontotemporal lobar degeneration with ubiquitin/TDP-43-positive inclusions}},
  journal = {Acta neuropathologica},
  year    = {2009},
  doi     = {10.1007/s00401-009-0493-4},
  pmid    = {19194716},
  url     = {https://doi.org/10.1007/s00401-009-0493-4}
}

@article{chouery2008-18546367,
  author  = {Chouery, E. and Delague, V. and Bergougnoux, A. and Koussa, S. and Serre, J. L. and Mégarbané, A.},
  title   = {{Mutations in TREM2 lead to pure early-onset dementia without bone cysts}},
  journal = {Human mutation},
  year    = {2008},
  doi     = {10.1002/humu.20836},
  pmid    = {18546367},
  url     = {https://doi.org/10.1002/humu.20836}
}

@article{kienlencampard2008-18201969,
  author  = {Kienlen-Campard, P. and Tasiaux, B. and Van Hees, J. and Li, M. and Huysseune, S. and Sato, T. and Fei, J. Z. and Aimoto, S. and others},
  title   = {{Amyloidogenic processing but not amyloid precursor protein (APP) intracellular C-terminal domain production requires a precisely oriented APP dimer assembled by transmembrane GXXXG motifs}},
  journal = {The Journal of biological chemistry},
  year    = {2008},
  doi     = {10.1074/jbc.m707142200},
  pmid    = {18201969},
  url     = {https://doi.org/10.1074/jbc.m707142200}
}

@article{hook2008-18184658,
  author  = {Hook, V. Y. and Kindy, M. and Hook, G.},
  title   = {{Inhibitors of cathepsin B improve memory and reduce beta-amyloid in transgenic Alzheimer disease mice expressing the wild-type, but not the Swedish mutant, beta-secretase site of the amyloid precursor protein}},
  journal = {The Journal of biological chemistry},
  year    = {2008},
  doi     = {10.1074/jbc.m708362200},
  pmid    = {18184658},
  url     = {https://doi.org/10.1074/jbc.m708362200}
}

@article{schmidt2007-17855360,
  author  = {Schmidt, V. and Sporbert, A. and Rohe, M. and Reimer, T. and Rehm, A. and Andersen, O. M. and Willnow, T. E.},
  title   = {{SorLA/LR11 regulates processing of amyloid precursor protein via interaction with adaptors GGA and PACS-1}},
  journal = {The Journal of biological chemistry},
  year    = {2007},
  doi     = {10.1074/jbc.m705073200},
  pmid    = {17855360},
  url     = {https://doi.org/10.1074/jbc.m705073200}
}

@article{mcconlogue2007-17616527,
  author  = {McConlogue, L. and Buttini, M. and Anderson, J. P. and Brigham, E. F. and Chen, K. S. and Freedman, S. B. and Games, D. and Johnson-Wood, K. and others},
  title   = {{Partial reduction of BACE1 has dramatic effects on Alzheimer plaque and synaptic pathology in APP Transgenic Mice}},
  journal = {The Journal of biological chemistry},
  year    = {2007},
  doi     = {10.1074/jbc.m611687200},
  pmid    = {17616527},
  url     = {https://doi.org/10.1074/jbc.m611687200}
}

@article{hooijmans2007-17720508,
  author  = {Hooijmans, C. R. and Rutters, F. and Dederen, P. J. and Gambarota, G. and Veltien, A. and van Groen, T. and Broersen, L. M. and Lütjohann, D. and others},
  title   = {{Changes in cerebral blood volume and amyloid pathology in aged Alzheimer APP/PS1 mice on a docosahexaenoic acid (DHA) diet or cholesterol enriched Typical Western Diet (TWD)}},
  journal = {Neurobiology of disease},
  year    = {2007},
  doi     = {10.1016/j.nbd.2007.06.007},
  pmid    = {17720508},
  url     = {https://doi.org/10.1016/j.nbd.2007.06.007}
}

@article{rae2007-17597598,
  author  = {Rae, F. and Woods, K. and Sasmono, T. and Campanale, N. and Taylor, D. and Ovchinnikov, D. A. and Grimmond, S. M. and Hume, D. A. and others},
  title   = {{Characterisation and trophic functions of murine embryonic macrophages based upon the use of a Csf1r-EGFP transgene reporter}},
  journal = {Developmental biology},
  year    = {2007},
  doi     = {10.1016/j.ydbio.2007.05.027},
  pmid    = {17597598},
  url     = {https://doi.org/10.1016/j.ydbio.2007.05.027}
}

@article{leroy2007-17239007,
  author  = {Leroy, K. and Yilmaz, Z. and Brion, J. P.},
  title   = {{Increased level of active GSK-3beta in Alzheimer's disease and accumulation in argyrophilic grains and in neurones at different stages of neurofibrillary degeneration}},
  journal = {Neuropathology and applied neurobiology},
  year    = {2007},
  doi     = {10.1111/j.1365-2990.2006.00795.x},
  pmid    = {17239007},
  url     = {https://doi.org/10.1111/j.1365-2990.2006.00795.x}
}

@article{neumann2007-17239445,
  author  = {Neumann, H. and Takahashi, K.},
  title   = {{Essential role of the microglial triggering receptor expressed on myeloid cells-2 (TREM2) for central nervous tissue immune homeostasis}},
  journal = {Journal of neuroimmunology},
  year    = {2007},
  doi     = {10.1016/j.jneuroim.2006.11.032},
  pmid    = {17239445},
  url     = {https://doi.org/10.1016/j.jneuroim.2006.11.032}
}

@article{kim2006-16959772,
  author  = {Kim, E. J. and Sung, J. Y. and Lee, H. J. and Rhim, H. and Hasegawa, M. and Iwatsubo, T. and Min do, S. and Kim, J. and others},
  title   = {{Dyrk1A phosphorylates alpha-synuclein and enhances intracellular inclusion formation}},
  journal = {The Journal of biological chemistry},
  year    = {2006},
  doi     = {10.1074/jbc.m606147200},
  pmid    = {16959772},
  url     = {https://doi.org/10.1074/jbc.m606147200}
}

@article{culbert2006-16774924,
  author  = {Culbert, A. A. and Skaper, S. D. and Howlett, D. R. and Evans, N. A. and Facci, L. and Soden, P. E. and Seymour, Z. M. and Guillot, F. and others},
  title   = {{MAPK-activated protein kinase 2 deficiency in microglia inhibits pro-inflammatory mediator release and resultant neurotoxicity. Relevance to neuroinflammation in a transgenic mouse model of Alzheimer disease}},
  journal = {The Journal of biological chemistry},
  year    = {2006},
  doi     = {10.1074/jbc.m513646200},
  pmid    = {16774924},
  url     = {https://doi.org/10.1074/jbc.m513646200}
}

@article{vetrivel2006-16930451,
  author  = {Vetrivel, K. S. and Zhang, Y. W. and Xu, H. and Thinakaran, G.},
  title   = {{Pathological and physiological functions of presenilins}},
  journal = {Molecular neurodegeneration},
  year    = {2006},
  doi     = {10.1186/1750-1326-1-4},
  pmid    = {16930451},
  url     = {https://doi.org/10.1186/1750-1326-1-4}
}

@article{williams2006-17118264,
  author  = {Williams, A. and Jahreiss, L. and Sarkar, S. and Saiki, S. and Menzies, F. M. and Ravikumar, B. and Rubinsztein, D. C.},
  title   = {{Aggregate-prone proteins are cleared from the cytosol by autophagy: therapeutic implications}},
  journal = {Current topics in developmental biology},
  year    = {2006},
  doi     = {10.1016/s0070-2153(06)76003-3},
  pmid    = {17118264},
  url     = {https://doi.org/10.1016/s0070-2153(06)76003-3}
}

@article{kayser2006-16356767,
  author  = {Kayser, J. and Tenke, C. E.},
  title   = {{Principal components analysis of Laplacian waveforms as a generic method for identifying ERP generator patterns: I. Evaluation with auditory oddball tasks}},
  journal = {Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology},
  year    = {2006},
  doi     = {10.1016/j.clinph.2005.08.034},
  pmid    = {16356767},
  url     = {https://doi.org/10.1016/j.clinph.2005.08.034}
}

@article{ferrer2005-16242644,
  author  = {Ferrer, I. and Barrachina, M. and Puig, B. and Martínez de Lagrán, M. and Martí, E. and Avila, J. and Dierssen, M.},
  title   = {{Constitutive Dyrk1A is abnormally expressed in Alzheimer disease, Down syndrome, Pick disease, and related transgenic models}},
  journal = {Neurobiology of disease},
  year    = {2005},
  doi     = {10.1016/j.nbd.2005.03.020},
  pmid    = {16242644},
  url     = {https://doi.org/10.1016/j.nbd.2005.03.020}
}

@article{humphrey2006-16418779,
  author  = {Humphrey, M. B. and Daws, M. R. and Spusta, S. C. and Niemi, E. C. and Torchia, J. A. and Lanier, L. L. and Seaman, W. E. and Nakamura, M. C.},
  title   = {{TREM2, a DAP12-associated receptor, regulates osteoclast differentiation and function}},
  journal = {Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year    = {2006},
  doi     = {10.1359/jbmr.051016},
  pmid    = {16418779},
  url     = {https://doi.org/10.1359/jbmr.051016}
}

@article{miao2005-16049335,
  author  = {Miao, J. and Xu, F. and Davis, J. and Otte-Höller, I. and Verbeek, M. M. and Van Nostrand, W. E.},
  title   = {{Cerebral microvascular amyloid beta protein deposition induces vascular degeneration and neuroinflammation in transgenic mice expressing human vasculotropic mutant amyloid beta precursor protein}},
  journal = {The American journal of pathology},
  year    = {2005},
  doi     = {10.1016/s0002-9440(10)62993-8},
  pmid    = {16049335},
  url     = {https://doi.org/10.1016/s0002-9440(10)62993-8}
}

@article{luedi2005-15930497,
  author  = {Luedi, P. P. and Hartemink, A. J. and Jirtle, R. L.},
  title   = {{Genome-wide prediction of imprinted murine genes}},
  journal = {Genome research},
  year    = {2005},
  doi     = {10.1101/gr.3303505},
  pmid    = {15930497},
  url     = {https://doi.org/10.1101/gr.3303505}
}

@article{anthony2005-15977645,
  author  = {Anthony, I. C. and Ramage, S. N. and Carnie, F. W. and Simmonds, P. and Bell, J. E.},
  title   = {{Influence of HAART on HIV-related CNS disease and neuroinflammation}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2005},
  doi     = {10.1093/jnen/64.6.529},
  pmid    = {15977645},
  url     = {https://doi.org/10.1093/jnen/64.6.529}
}

@article{cole2005-15718241,
  author  = {Cole, S. L. and Grudzien, A. and Manhart, I. O. and Kelly, B. L. and Oakley, H. and Vassar, R.},
  title   = {{Statins cause intracellular accumulation of amyloid precursor protein, beta-secretase-cleaved fragments, and amyloid beta-peptide via an isoprenoid-dependent mechanism}},
  journal = {The Journal of biological chemistry},
  year    = {2005},
  doi     = {10.1074/jbc.m413895200},
  pmid    = {15718241},
  url     = {https://doi.org/10.1074/jbc.m413895200}
}

@article{zhang2005-15711015,
  author  = {Zhang, Y. W. and Luo, W. J. and Wang, H. and Lin, P. and Vetrivel, K. S. and Liao, F. and Li, F. and Wong, P. C. and others},
  title   = {{Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components}},
  journal = {The Journal of biological chemistry},
  year    = {2005},
  doi     = {10.1074/jbc.m409467200},
  pmid    = {15711015},
  url     = {https://doi.org/10.1074/jbc.m409467200}
}

@article{takeuchi2005-15640150,
  author  = {Takeuchi, H. and Mizuno, T. and Zhang, G. and Wang, J. and Kawanokuchi, J. and Kuno, R. and Suzumura, A.},
  title   = {{Neuritic beading induced by activated microglia is an early feature of neuronal dysfunction toward neuronal death by inhibition of mitochondrial respiration and axonal transport}},
  journal = {The Journal of biological chemistry},
  year    = {2005},
  doi     = {10.1074/jbc.m413863200},
  pmid    = {15640150},
  url     = {https://doi.org/10.1074/jbc.m413863200}
}

@article{chao2005-15668426,
  author  = {Chao, L. L. and Schuff, N. and Kramer, J. H. and Du, A. T. and Capizzano, A. A. and O'Neill, J. and Wolkowitz, O. M. and Jagust, W. J. and others},
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  title   = {{Evidence for reduced somatic T-cell receptor sequence diversity profiles among Midwestern Amish in an aging cohort study}},
  journal = {Annals of human genetics},
  year    = {2026},
  doi     = {10.64898/2026.01.25.26344754},
  url     = {https://doi.org/10.64898/2026.01.25.26344754}
}

@article{hadad2026-41799019,
  author  = {Hadad, Rafi and Cobigo, Yann and Milicic, Andjelika and Tsoy, Elena and Mandelli, Maria Luisa and Wolf, Amy A. and Gaynor, Leslie S. and Possin, Katherine L. and others},
  title   = {{White Matter Hyperintensities in Behavioral Variant Frontotemporal Dementia and Semantic Variant Primary Progressive Aphasia}},
  journal = {Neurology Open Access},
  year    = {2026},
  doi     = {10.1212/wn9.0000000000000064},
  pmid    = {41799019},
  url     = {https://doi.org/10.1212/wn9.0000000000000064}
}

@article{arbaciauskaite2026-41678018,
  author  = {Arbaciauskaite, Skaiste and Silvestri, Simona and Luo, Pingyan and Krüger, Christina and Mossmann, Zoé J. and Allelein, Susann and Scholz, Alexander and Löffler, Dennis and others},
  title   = {{Microglia-Derived Extracellular Vesicles from Alzheimer’s Disease Patients Carry miRNAs Driving a Neuroinflammatory Response}},
  journal = {Molecular Neurobiology},
  year    = {2026},
  doi     = {10.1007/s12035-026-05719-w},
  pmid    = {41678018},
  url     = {https://doi.org/10.1007/s12035-026-05719-w}
}

@article{wang2026-41478827,
  author  = {Wang, Han and Li, Zhi-Ming and Xiong, Benbo and Wang, Zi-Jie and Qian, Yi and Hu, Xiao and Zhang, Shan-Yu and Chen, Chu and others},
  title   = {{The association of estimated glucose disposal rate with white matter hyperintensities: A large prospective cohort study}},
  journal = {The Journal of Prevention of Alzheimer s Disease},
  year    = {2026},
  doi     = {10.1016/j.tjpad.2025.100464},
  pmid    = {41478827},
  url     = {https://doi.org/10.1016/j.tjpad.2025.100464}
}

@article{rajkumar2025-41385896,
  author  = {Rajkumar, Anto Praveen and Hye, Abdul and Tan, Shirlee and Green, Holly and Killick, Richard and Nizamudeen, Zubair Ahmed and Işık, Fatma Büşra and Figueredo, Grazziela Patrocinio and others},
  title   = {{Transcriptomic analysis of plasma small extracellular vesicles identifies potential diagnostic biomarkers for Parkinson's disease dementia}},
  journal = {Parkinsonism \& Related Disorders},
  year    = {2025},
  doi     = {10.1016/j.parkreldis.2025.108150},
  pmid    = {41385896},
  url     = {https://doi.org/10.1016/j.parkreldis.2025.108150}
}

@article{josephmathurin2025-41517928,
  author  = {Joseph‐Mathurin, Nelly and Chen, Charles D. and Hobbs, Diana A and Jiang, Meng and Flores, Shaney E. and Scott, Jalen and Anand, Sanjana and Franklin, Erin E. and others},
  title   = {{Imaging‐neuropathology evaluation of Amyloid Related Imaging Abnormality sulcal effusion in a DIAN‐TU‐001 participant treated with gantenerumab}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70856_107139},
  pmid    = {41517928},
  url     = {https://doi.org/10.1002/alz70856_107139}
}

@article{morcillonieto2025-41433511,
  author  = {Morcillo-Nieto, Alejandra Omaira and Arriola‐Infante, José Enrique and Franquesa‐Mullerat, María and Zsadanyi, Sára E. and Vaqué‐Alcázar, Lídia and Aranha, Mateus Rozalem and Parra, Jose Allende and Zhao, Zili and others},
  title   = {{Early Detection of White Matter Integrity Changes in Down Syndrome: The Promise of PSMD as a Sensitive Biomarker}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70862_109982},
  pmid    = {41433511},
  url     = {https://doi.org/10.1002/alz70862_109982}
}

@article{paes2025-41499176,
  author  = {Paes, Vítor Ribeiro and Justo, Alberto Fernando Oliveira and Silva, Caroline Matos and Rodriguez, Roberta and Leite, Renata Elaine Paraízo and Suemoto, Cláudia Kimie and Pasqualucci, Carlos Augusto and Ferriolli, Eduardo and others},
  title   = {{Bridging the Gap: Can Hippocampal Sclerosis Serve as a Surrogate Biomarker for LATE‐NC?}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70856_107174},
  pmid    = {41499176},
  url     = {https://doi.org/10.1002/alz70856_107174}
}

@article{didomenico2025-41269384,
  author  = {Di Domenico, F. and Greco, V. and Tramutola, A. and Rataj-Baniowska, M. and Barone, E. and Lanzillotta, C. and Pieroni, L. and Butterfield, D. A. and others},
  title   = {{Proteome Signature of Alzheimer-Like Phenotypes in Frontal Cortices From Young and Old Individuals With Down Syndrome}},
  journal = {Molecular neurobiology},
  year    = {2025},
  doi     = {10.1007/s12035-025-05432-0},
  pmid    = {41269384},
  url     = {https://doi.org/10.1007/s12035-025-05432-0}
}

@article{etani2025-41261421,
  author  = {Etani, Hayato and Takatori, Sho and Wang, Wenbo and Omi, Jumpei and Amiya, Yusuke and Akahori, Aika and Watanabe, Hirotaka and Sonn, Iki and others},
  title   = {{Selective agonism of GPR34 stimulates microglial uptake and clearance of amyloid β fibrils}},
  journal = {Alzheimer s Research \& Therapy},
  year    = {2025},
  doi     = {10.1186/s13195-025-01891-8},
  pmid    = {41261421},
  url     = {https://doi.org/10.1186/s13195-025-01891-8}
}

@article{labarbera2025-41077614,
  author  = {La Barbera, Livia and Krashia, Paraskevi and Loffredo, Gilda and Cauzzi, Emma and De Paolis, Maria Luisa and Montanari, Martina and Saba, Luana and Spoleti, Elena and others},
  title   = {{Midbrain degeneration triggers astrocyte reactivity and tau pathology in experimental Alzheimer’s Disease}},
  journal = {Molecular Neurodegeneration},
  year    = {2025},
  doi     = {10.1186/s13024-025-00893-2},
  pmid    = {41077614},
  url     = {https://doi.org/10.1186/s13024-025-00893-2}
}

@article{james2025-41061670,
  author  = {James, Rebecca E. and Bekier, Michael E. and Lee, P. and Schroeder, Frederick A. and Evans, Lauren Jayne and Wagner, Florence F. and Hickman, Dean and Richardson, Tom and others},
  title   = {{A next-generation HDAC6 inhibitor for amyotrophic lateral sclerosis and frontotemporal dementia}},
  journal = {Brain},
  year    = {2025},
  doi     = {10.1093/brain/awaf380},
  pmid    = {41061670},
  url     = {https://doi.org/10.1093/brain/awaf380}
}

@article{woo2025-41075284,
  author  = {Woo, Kyung Ah and Yoon, Eun Jin and Kim, Ryul and Kim, Heejung and Kim, Seo-Yeon and Jin, Bora and Lee, Seungmin and Kim, Yu Kyeong and others},
  title   = {{Plasma p‐tau217 and Aβ42/40 as markers of Aβ pathology in the Lewy body continuum}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz.70788},
  pmid    = {41075284},
  url     = {https://doi.org/10.1002/alz.70788}
}

@article{pir2025-40891506,
  author  = {Pir, Ghulam Jeelani and Buddenkotte, Joerg and Alam, Majid Ali and Own, Ahmed M. and Eck, Randall J. and Kraemer, Brian C. and Mandelkow�, Eckhard and Steinhoff, Martin S.},
  title   = {{TDP ‐43 proteinopathies and neurodegeneration: insights from Caenorhabditis elegans models}},
  journal = {FEBS Journal},
  year    = {2025},
  doi     = {10.1111/febs.70239},
  pmid    = {40891506},
  url     = {https://doi.org/10.1111/febs.70239}
}

@article{ambaw2025-40922380,
  author  = {Ambaw, Yohannes Abere and Ljubenkov, Peter Alexander and Singh, Shubham and Hamed, Abdi and Boland, Sebastian and Boxer, Adam L. and Walther, Tobias C. and Farese, Robert V.},
  title   = {{Plasma lipidome dysregulation in frontotemporal dementia reveals shared, genotype‐specific, and severity‐linked alterations}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz.70631},
  pmid    = {40922380},
  url     = {https://doi.org/10.1002/alz.70631}
}

@article{hauer2025-40885039,
  author  = {Hauer, Kevin Oliveira and Hall, Sara and Nahimi, Adjmal and Strandberg, Olof T. and Ohlsson, Tomas G. and Jögi, Jonas and Stomrud, Erik and Janelidze, Shorena and others},
  title   = {{CSF markers of neuroinflammation, synaptic dysfunction and [18F]DOPA-PET in Parkinson's disease}},
  journal = {Parkinsonism \& Related Disorders},
  year    = {2025},
  doi     = {10.1016/j.parkreldis.2025.108005},
  pmid    = {40885039},
  url     = {https://doi.org/10.1016/j.parkreldis.2025.108005}
}

@article{feneberg2025-40826370,
  author  = {Feneberg, Emily and Thompson, Alexander G. and Charles, Philip D. and Vendrell, Iolanda and Kessler, Benedikt M. and Fischer, Román and Ansorge, Olaf and Gray, Elizabeth E. and others},
  title   = {{TDP-43 pathology is associated with divergent protein profiles in ALS brain and spinal cord}},
  journal = {Acta Neuropathologica Communications},
  year    = {2025},
  doi     = {10.1186/s40478-025-02084-y},
  pmid    = {40826370},
  url     = {https://doi.org/10.1186/s40478-025-02084-y}
}

@article{sekiya2025-40755115,
  author  = {Sekiya, Hiroaki and Franke, Lukas and Ono, Daisuke and Deture, Michael A. and Ross, Owen A. and Murray, Melissa Erin and McLean, Pamela J. and Ferman, Tanis J. and others},
  title   = {{Impact of hippocampal α‐synuclein oligomers on cognitive trajectory in patients with dementia with Lewy bodies}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz.70374},
  pmid    = {40755115},
  url     = {https://doi.org/10.1002/alz.70374}
}

@article{langness2025-40826256,
  author  = {Langness, Vanessa F. and Simmons, Danielle A. and McHugh, Tyne L.M. and Butler, Robert R. and Zhou, James and Liu, Harry and Yang, Tao and Ellerby, Lisa and others},
  title   = {{Twenty years of therapeutic development in tauopathy mouse models: a scoping review}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz.70578},
  pmid    = {40826256},
  url     = {https://doi.org/10.1002/alz.70578}
}

@article{xu2025-40757274,
  author  = {Xu, Guangqi and Zhang, Qinghua and Li, Yinan and Du, Anqi and Xu, Xiaona and Bai, Ruyu and Bi, Chao and Li, Yanxia and others},
  title   = {{Cerebrospinal Fluid p-Tau181/Amyloid Beta 42 Ratio Identifies Lymphatic-Venous Anastomosis Patients Who Respond to and Benefit from the Surgery for Relief of Cognitive Impairment with a Diagnostic Accuracy of 0.744}},
  journal = {ACS Omega},
  year    = {2025},
  doi     = {10.1021/acsomega.5c03650},
  pmid    = {40757274},
  url     = {https://doi.org/10.1021/acsomega.5c03650}
}

@article{vikner2025-40671018,
  author  = {Vikner, Tomas P. and Garpebring, Anders and Björnfot, Cecilia and Malm, Jan and Eklund, Anders and Wåhlin, Anders},
  title   = {{MRI contrast accumulation in features of cerebral small vessel disease: blood-brain barrier dysfunction or elevated vascular density?}},
  journal = {Fluids and Barriers of the CNS},
  year    = {2025},
  doi     = {10.1186/s12987-025-00675-4},
  pmid    = {40671018},
  url     = {https://doi.org/10.1186/s12987-025-00675-4}
}

@article{bommarito2025-40646592,
  author  = {Bommarito, Giulia and Griffa, Alessandra and Michel, Patrik and Caroline, Hall and Salvioni, Chiabotti Paolo and Pistocchi, Silvia and Alemán-Gómez, Yasser and Damian, Daniel and others},
  title   = {{Cerebral small vessel disease in memory center patients with dementia with lewy bodies and Alzheimer’s disease}},
  journal = {Alzheimer s Research \& Therapy},
  year    = {2025},
  doi     = {10.1186/s13195-025-01805-8},
  pmid    = {40646592},
  url     = {https://doi.org/10.1186/s13195-025-01805-8}
}

@article{bregendahl2025-40598304,
  author  = {Bregendahl, Maria Esperanza and Kaya, Zeynep Bengisu and Singer, Wolfgang and McLean, Pamela J.},
  title   = {{Alpha-synuclein seeding amplification assays in Lewy body dementia: a brief review}},
  journal = {Molecular Neurodegeneration},
  year    = {2025},
  doi     = {10.1186/s13024-025-00868-3},
  pmid    = {40598304},
  url     = {https://doi.org/10.1186/s13024-025-00868-3}
}

@article{rory2025-40463548,
  author  = {Rory, Boyle and Nadia, Dehghani and Sheina, Emrani and Wadhwani Anil, R. and Melanie, Matyi and Cousins Katheryn A, Q. and Emma, Rhodes and Brian, Nelson and others},
  title   = {{Higher neighborhood deprivation is associated with accelerated disease progression in behavioral-variant frontotemporal degeneration}},
  journal = {Alzheimer's \& dementia. Behavior \& socioeconomics of aging},
  year    = {2025},
  doi     = {10.1101/2025.05.12.25327099},
  pmid    = {40463548},
  url     = {https://doi.org/10.1101/2025.05.12.25327099}
}

@article{kurose2025-40488253,
  author  = {Kurose, Shin and Moriguchi, Sho and Kubota, Manabu and Tagai, Kenji and Momota, Yuki and Ichihashi, Masanori and Sano, Yasunori and Endo, Hironobu and others},
  title   = {{Diverse tau pathologies in late‐life mood disorders revealed by PET and autopsy assays}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz.70195},
  pmid    = {40488253},
  url     = {https://doi.org/10.1002/alz.70195}
}

@article{miller2025-40279247,
  author  = {Miller, Cameron R. and Ealy, Alyssa and Gregory, Amanda and Janarthanam, Chelva and Albers, William G and Richardson, Gabriel and Jin, Huajun and Zenitsky, Gary D. and others},
  title   = {{Pathological α-synuclein dysregulates epitranscriptomic writer METTL3 to drive neuroinflammation in microglia}},
  journal = {Cell Reports},
  year    = {2025},
  doi     = {10.1016/j.celrep.2025.115618},
  pmid    = {40279247},
  url     = {https://doi.org/10.1016/j.celrep.2025.115618}
}

@article{kallai2025-40214958,
  author  = {Kállai, Attila and Ungvari, Anna and Csabán, Dóra and Őrfi, Zoltán and Lehoczki, Andrea and Harasztdombi, József and Yabluchanskiy, Andriy and Benyó, Zoltán and others},
  title   = {{Clonal hematopoiesis of indeterminate potential (CHIP) in cerebromicrovascular aging: implications for vascular contributions to cognitive impairment and dementia (VCID)}},
  journal = {GeroScience},
  year    = {2025},
  doi     = {10.1007/s11357-025-01654-1},
  pmid    = {40214958},
  url     = {https://doi.org/10.1007/s11357-025-01654-1}
}

@article{amato2025-40188185,
  author  = {Amato, Lorenzo Gaetano and Vergani, Alberto Arturo and Lassi, Michael and Carpaneto, Jacopo and Mazzeo, Salvatore and Moschini, Valentina and Burali, Rachele and Salvestrini, Giovanni and others},
  title   = {{Personalized brain models link cognitive decline progression to underlying synaptic and connectivity degeneration}},
  journal = {Alzheimer s Research \& Therapy},
  year    = {2025},
  doi     = {10.1186/s13195-025-01718-6},
  pmid    = {40188185},
  url     = {https://doi.org/10.1186/s13195-025-01718-6}
}

@article{patai2025-40169521,
  author  = {Patai, Roland and Patel, Krish and Csík, Boglárka and Gulej, Rafał and Nagaraja, Raghavendra Yelahanka and Nagy, Dorina and Chandragiri, Siva Sai and Shanmugarama, Santny and others},
  title   = {{Aging, mitochondrial dysfunction, and cerebral microhemorrhages: a preclinical evaluation of SS-31 (elamipretide) and development of a high-throughput machine learning-driven imaging pipeline for cerebromicrovascular protection therapeutic screening}},
  journal = {GeroScience},
  year    = {2025},
  doi     = {10.1007/s11357-025-01634-5},
  pmid    = {40169521},
  url     = {https://doi.org/10.1007/s11357-025-01634-5}
}

@article{hou2025-40309932,
  author  = {Hou, Xu and Heckman, Michael G. and Fiesel, Fabienne C. and Koga, Shunsuke and Soto‐Beasley, Alexandra I. and Watzlawik, Jens O. and Zhao, Jing and Valentino, Rebecca R. and others},
  title   = {{Genome‐wide association analysis identifies APOE as a mitophagy modifier in Lewy body disease}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz.70198},
  pmid    = {40309932},
  url     = {https://doi.org/10.1002/alz.70198}
}

@article{nemati2025-40170060,
  author  = {Nemati, Reza and Sohrabi-Ashlaghi, Ahmadreza and Saberian, Parsa and Sadeghi, Mohammad and Mardani, Sajjad and Abadi, Alireza and Yaghoobpoor, Ali and Heydari, Atefeh Sadat and others},
  title   = {{Growth associated protein 43 (GAP-43) predicts brain amyloidosis in Alzheimer’s dementia continuum: an [18 F] AV-45 study}},
  journal = {BMC Neurology},
  year    = {2025},
  doi     = {10.1186/s12883-025-04140-5},
  pmid    = {40170060},
  url     = {https://doi.org/10.1186/s12883-025-04140-5}
}

@article{peterson2025-40352684,
  author  = {Peterson, Amalia Jo and Sun, Yunyi and Archer, Derek B. and Kresge, Hailey A. and Moore, Elizabeth E. and Deberghes, Isabella and Pechman, Kimberly R. and Shashikumar, Niranjana and others},
  title   = {{Cerebrospinal fluid YKL‐40 relates to white matter hyperintensity progression in females but not males over a 6‐year period}},
  journal = {Alzheimer s \& Dementia Diagnosis Assessment \& Disease Monitoring},
  year    = {2025},
  doi     = {10.1002/dad2.70110},
  pmid    = {40352684},
  url     = {https://doi.org/10.1002/dad2.70110}
}

@article{ceccarelli2025-40137124,
  author  = {Ceccarelli, Daniela Ceccarelli and Solerte, Sebastiano Bruno},
  title   = {{Unravelling Shared Pathways Linking Metabolic Syndrome, Mild Cognitive Impairment, Dementia, and Sarcopenia}},
  journal = {Metabolites},
  year    = {2025},
  doi     = {10.3390/metabo15030159},
  pmid    = {40137124},
  url     = {https://doi.org/10.3390/metabo15030159}
}

@article{alcalalozano2025-40004217,
  author  = {Alcalá‐Lozano, Ruth and Carmona-Hernández, Rocio and Ocampo-Romero, Ana Gabriela and Sosa-Millán, Adriana Leticia and Morelos-Santana, E. and Abarca, Diana Zapata and Castro-de-Aquino, Dana Vianey and Cabrera-Muñoz, Edith Araceli and others},
  title   = {{Predicting the Beneficial Effects of Cognitive Stimulation and Transcranial Direct Current Stimulation in Amnestic Mild Cognitive Impairment with Clinical, Inflammation, and Human Microglia Exposed to Serum as Potential Markers: A Double-Blind Placebo-Controlled Randomized Clinical Trial}},
  journal = {International Journal of Molecular Sciences},
  year    = {2025},
  doi     = {10.3390/ijms26041754},
  pmid    = {40004217},
  url     = {https://doi.org/10.3390/ijms26041754}
}

@article{xie2025-39941141,
  author  = {Xie, Haihua and Jiang, Jia‐Qian and Cao, Sihui and Xu, Xuan and Zhou, Jingyin and Zhang, Ruhan and Huang, Bo and Lu, Peicheng and others},
  title   = {{The Role of Gut Microbiota-Derived Trimethylamine N-Oxide in the Pathogenesis and Treatment of Mild Cognitive Impairment}},
  journal = {International Journal of Molecular Sciences},
  year    = {2025},
  doi     = {10.3390/ijms26031373},
  pmid    = {39941141},
  url     = {https://doi.org/10.3390/ijms26031373}
}

@article{sampson2025-39885558,
  author  = {Sampson, Timothy Robert and Tansey, Malú G. and West, Andrew B. and Liddle, Rodger A.},
  title   = {{Lewy body diseases and the gut}},
  journal = {Molecular Neurodegeneration},
  year    = {2025},
  doi     = {10.1186/s13024-025-00804-5},
  pmid    = {39885558},
  url     = {https://doi.org/10.1186/s13024-025-00804-5}
}

@article{liu2025-39755715,
  author  = {Liu, Qing H. and Sun, Ye and He, Baodong and Chen, Haodong and Wang, Lijing and Wang, Gaojie and Zhang, Kang and Zhao, Ximeng and others},
  title   = {{Gain-of-function ANXA11 mutation cause late-onset ALS with aberrant protein aggregation, neuroinflammation and autophagy impairment}},
  journal = {Acta Neuropathologica Communications},
  year    = {2025},
  doi     = {10.1186/s40478-024-01919-4},
  pmid    = {39755715},
  url     = {https://doi.org/10.1186/s40478-024-01919-4}
}

@article{nassan2025-40103583,
  author  = {Nassan, Malik M. and Daghlas, Iyas and Diamond, Bram R and Martersteck, Adam and Rogalski, Emily Joy},
  title   = {{The causal association between resting state intrinsic functional networks and neurodegeneration}},
  journal = {Brain Communications},
  year    = {2025},
  doi     = {10.1093/braincomms/fcaf098},
  pmid    = {40103583},
  url     = {https://doi.org/10.1093/braincomms/fcaf098}
}

@article{chiu2025-39758054,
  author  = {Chiu, Yen‐Ling and Yan, Sui‐Hing and Fan, Yang‐Teng and Chang, Chiung‐Fang and Hung, Ruo‐Wei and Liu, Yi‐Chien and Yang, TienYu Owen and Chuang, Yi‐Fang},
  title   = {{Aβ‐reactive T cell polyfunctionality response as a new biomarker for mild cognitive impairment}},
  journal = {Alzheimer s \& Dementia Diagnosis Assessment \& Disease Monitoring},
  year    = {2025},
  doi     = {10.1002/dad2.70042},
  pmid    = {39758054},
  url     = {https://doi.org/10.1002/dad2.70042}
}

@article{park2024-39255397,
  author  = {Park, G. and Kadyan, S. and Hochuli, N. and Salazar, G. and Laitano, O. and Chakrabarty, P. and Efron, P. A. and Zafar, M. A. and others},
  title   = {{An Enteric Bacterial Infection Triggers Neuroinflammation and Neurobehavioral Impairment in 3xTg-AD Transgenic Mice}},
  journal = {The Journal of infectious diseases},
  year    = {2024},
  doi     = {10.1093/infdis/jiae165},
  pmid    = {39255397},
  url     = {https://doi.org/10.1093/infdis/jiae165}
}

@article{chen2024-38747498,
  author  = {Chen, X. Q. and Becker, A. and Albay, R. and Nguyen, P. D. and Karachentsev, D. and Roberts, A. J. and Rynearson, K. D. and Tanzi, R. E. and others},
  title   = {{γ-Secretase Modulator BPN15606 Reduced Aβ42 and Aβ40 and Countered Alzheimer-Related Pathologies in a Mouse Model of Down Syndrome}},
  journal = {Annals of neurology},
  year    = {2024},
  doi     = {10.1002/ana.26958},
  pmid    = {38747498},
  url     = {https://doi.org/10.1002/ana.26958}
}

@article{tang2024-37915255,
  author  = {Tang, X. and Walter, E. and Wohleb, E. and Fan, Y. and Wang, C.},
  title   = {{ATG5 (autophagy related 5) in microglia controls hippocampal neurogenesis in Alzheimer disease}},
  journal = {Autophagy},
  year    = {2024},
  doi     = {10.1080/15548627.2023.2277634},
  pmid    = {37915255},
  url     = {https://doi.org/10.1080/15548627.2023.2277634}
}

@article{xie2023-37859748,
  author  = {Xie, X. and Song, Q. and Dai, C. and Cui, S. and Tang, R. and Li, S. and Chang, J. and Li, P. and others},
  title   = {{Clinical safety and efficacy of allogenic human adipose mesenchymal stromal cells-derived exosomes in patients with mild to moderate Alzheimer's disease: a phase I/II clinical trial}},
  journal = {General psychiatry},
  year    = {2023},
  doi     = {10.1136/gpsych-2023-101143},
  pmid    = {37859748},
  url     = {https://doi.org/10.1136/gpsych-2023-101143}
}

@article{feng2023-37351177,
  author  = {Feng, S. and Wu, C. and Zou, P. and Deng, Q. and Chen, Z. and Li, M. and Zhu, L. and Li, F. and others},
  title   = {{High-intensity interval training ameliorates Alzheimer's disease-like pathology by regulating astrocyte phenotype-associated AQP4 polarization}},
  journal = {Theranostics},
  year    = {2023},
  doi     = {10.7150/thno.81951},
  pmid    = {37351177},
  url     = {https://doi.org/10.7150/thno.81951}
}

@article{micheli2023-37049607,
  author  = {Micheli, L. and Bertini, L. and Bonato, A. and Villanova, N. and Caruso, C. and Caruso, M. and Bernini, R. and Tirone, F.},
  title   = {{Role of Hydroxytyrosol and Oleuropein in the Prevention of Aging and Related Disorders: Focus on Neurodegeneration, Skeletal Muscle Dysfunction and Gut Microbiota}},
  journal = {Nutrients},
  year    = {2023},
  doi     = {10.3390/nu15071767},
  pmid    = {37049607},
  url     = {https://doi.org/10.3390/nu15071767}
}

@article{luo2023-37003186,
  author  = {Luo, Q. and Deng, D. and Li, Y. and Shi, H. and Zhao, J. and Qian, Q. and Wang, W. and Cai, J. and others},
  title   = {{TREM2 Insufficiency Protects against Pulmonary Fibrosis by Inhibiting M2 Macrophage Polarization}},
  journal = {International immunopharmacology},
  year    = {2023},
  doi     = {10.1016/j.intimp.2023.110070},
  pmid    = {37003186},
  url     = {https://doi.org/10.1016/j.intimp.2023.110070}
}

@article{zhou2023-36989373,
  author  = {Zhou, J. and Wade, S. D. and Graykowski, D. and Xiao, M. F. and Zhao, B. and Giannini, L. A. A. and Hanson, J. E. and van Swieten, J. C. and others},
  title   = {{The neuronal pentraxin Nptx2 regulates complement activity and restrains microglia-mediated synapse loss in neurodegeneration}},
  journal = {Science translational medicine},
  year    = {2023},
  doi     = {10.1126/scitranslmed.adf0141},
  pmid    = {36989373},
  url     = {https://doi.org/10.1126/scitranslmed.adf0141}
}

@article{kalyan2022-36552802,
  author  = {Kalyan, M. and Tousif, A. H. and Sonali, S. and Vichitra, C. and Sunanda, T. and Praveenraj, S. S. and Ray, B. and Gorantla, V. R. and others},
  title   = {{Role of Endogenous Lipopolysaccharides in Neurological Disorders}},
  journal = {Cells},
  year    = {2022},
  doi     = {10.3390/cells11244038},
  pmid    = {36552802},
  url     = {https://doi.org/10.3390/cells11244038}
}

@article{faridar2022-36180898,
  author  = {Faridar, A. and Vasquez, M. and Thome, A. D. and Yin, Z. and Xuan, H. and Wang, J. H. and Wen, S. and Li, X. and others},
  title   = {{Ex vivo expanded human regulatory T cells modify neuroinflammation in a preclinical model of Alzheimer's disease}},
  journal = {Acta neuropathologica communications},
  year    = {2022},
  doi     = {10.1186/s40478-022-01447-z},
  pmid    = {36180898},
  url     = {https://doi.org/10.1186/s40478-022-01447-z}
}

@article{han2022-36041498,
  author  = {Han, X. and Cheng, X. and Xu, J. and Liu, Y. and Zhou, J. and Jiang, L. and Gu, X. and Xia, T.},
  title   = {{Activation of TREM2 attenuates neuroinflammation via PI3K/Akt signaling pathway to improve postoperative cognitive dysfunction in mice}},
  journal = {Neuropharmacology},
  year    = {2022},
  doi     = {10.1016/j.neuropharm.2022.109231},
  pmid    = {36041498},
  url     = {https://doi.org/10.1016/j.neuropharm.2022.109231}
}

@article{dabla2022-35924849,
  author  = {Dabla, A. and Liang, Y. C. and Rajabalee, N. and Irwin, C. and Moonen, C. G. J. and Willis, J. V. and Berton, S. and Sun, J.},
  title   = {{TREM2 Promotes Immune Evasion by Mycobacterium tuberculosis in Human Macrophages}},
  journal = {mBio},
  year    = {2022},
  doi     = {10.1128/mbio.01456-22},
  pmid    = {35924849},
  url     = {https://doi.org/10.1128/mbio.01456-22}
}

@article{moreau2022-35740400,
  author  = {Moreau, M. and Carmona-Iragui, M. and Altuna, M. and Dalzon, L. and Barroeta, I. and Vilaire, M. and Durand, S. and Fortea, J. and others},
  title   = {{DYRK1A and Activity-Dependent Neuroprotective Protein Comparative Diagnosis Interest in Cerebrospinal Fluid and Plasma in the Context of Alzheimer-Related Cognitive Impairment in Down Syndrome Patients}},
  journal = {Biomedicines},
  year    = {2022},
  doi     = {10.3390/biomedicines10061380},
  pmid    = {35740400},
  url     = {https://doi.org/10.3390/biomedicines10061380}
}

@article{liu2022-35366241,
  author  = {Liu, H. and Jin, M. and Ji, M. and Zhang, W. and Liu, A. and Wang, T.},
  title   = {{Hypoxic pretreatment of adipose-derived stem cell exosomes improved cognition by delivery of circ-Epc1 and shifting microglial M1/M2 polarization in an Alzheimer's disease mice model}},
  journal = {Aging},
  year    = {2022},
  doi     = {10.18632/aging.203989},
  pmid    = {35366241},
  url     = {https://doi.org/10.18632/aging.203989}
}

@article{dodge2022-35105352,
  author  = {Dodge, J. C. and Tamsett, T. J. and Treleaven, C. M. and Taksir, T. V. and Piepenhagen, P. and Sardi, S. P. and Cheng, S. H. and Shihabuddin, L. S.},
  title   = {{Glucosylceramide synthase inhibition reduces ganglioside GM3 accumulation, alleviates amyloid neuropathology, and stabilizes remote contextual memory in a mouse model of Alzheimer's disease}},
  journal = {Alzheimer's research \& therapy},
  year    = {2022},
  doi     = {10.1186/s13195-022-00966-0},
  pmid    = {35105352},
  url     = {https://doi.org/10.1186/s13195-022-00966-0}
}

@article{boyarko2021-34744602,
  author  = {Boyarko, B. and Hook, V.},
  title   = {{Human Tau Isoforms and Proteolysis for Production of Toxic Tau Fragments in Neurodegeneration}},
  journal = {Frontiers in neuroscience},
  year    = {2021},
  doi     = {10.3389/fnins.2021.702788},
  pmid    = {34744602},
  url     = {https://doi.org/10.3389/fnins.2021.702788}
}

@article{hoyerkimura2021-34654436,
  author  = {Hoyer-Kimura, C. and Konhilas, J. P. and Mansour, H. M. and Polt, R. and Doyle, K. P. and Billheimer, D. and Hay, M.},
  title   = {{Neurofilament light: a possible prognostic biomarker for treatment of vascular contributions to cognitive impairment and dementia}},
  journal = {Journal of neuroinflammation},
  year    = {2021},
  doi     = {10.1186/s12974-021-02281-1},
  pmid    = {34654436},
  url     = {https://doi.org/10.1186/s12974-021-02281-1}
}

@article{zhao2021-34593014,
  author  = {Zhao, F. and Xu, Y. and Gao, S. and Qin, L. and Austria, Q. and Siedlak, S. L. and Pajdzik, K. and Dai, Q. and others},
  title   = {{METTL3-dependent RNA m6A dysregulation contributes to neurodegeneration in Alzheimer's disease through aberrant cell cycle events}},
  journal = {Molecular neurodegeneration},
  year    = {2021},
  doi     = {10.1186/s13024-021-00484-x},
  pmid    = {34593014},
  url     = {https://doi.org/10.1186/s13024-021-00484-x}
}

@article{kim2021-34363663,
  author  = {Kim, S. H. and Farrell, K. and Cosentino, S. and Vonsattel, J. G. and Faust, P. L. and Cortes, E. P. and Bennet, D. A. and Louis, E. D. and others},
  title   = {{Tau Isoform Profile in Essential Tremor Diverges From Other Tauopathies}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2021},
  doi     = {10.1093/jnen/nlab073},
  pmid    = {34363663},
  url     = {https://doi.org/10.1093/jnen/nlab073}
}

@article{tong2022-34313551,
  author  = {Tong, B. C. and Wu, A. J. and Huang, A. S. and Dong, R. and Malampati, S. and Iyaswamy, A. and Krishnamoorthi, S. and Sreenivasmurthy, S. G. and others},
  title   = {{Lysosomal TPCN (two pore segment channel) inhibition ameliorates beta-amyloid pathology and mitigates memory impairment in Alzheimer disease}},
  journal = {Autophagy},
  year    = {2022},
  doi     = {10.1080/15548627.2021.1945220},
  pmid    = {34313551},
  url     = {https://doi.org/10.1080/15548627.2021.1945220}
}

@article{zhou2021-34108016,
  author  = {Zhou, Y. and Xu, J. and Hou, Y. and Leverenz, J. B. and Kallianpur, A. and Mehra, R. and Liu, Y. and Yu, H. and others},
  title   = {{Network medicine links SARS-CoV-2/COVID-19 infection to brain microvascular injury and neuroinflammation in dementia-like cognitive impairment}},
  journal = {Alzheimer's research \& therapy},
  year    = {2021},
  doi     = {10.1186/s13195-021-00850-3},
  pmid    = {34108016},
  url     = {https://doi.org/10.1186/s13195-021-00850-3}
}

@article{apodaca2021-33676561,
  author  = {Apodaca, L. A. and Baddour, A. A. D. and Garcia, C. and Alikhani, L. and Giedzinski, E. and Ru, N. and Agrawal, A. and Acharya, M. M. and others},
  title   = {{Human neural stem cell-derived extracellular vesicles mitigate hallmarks of Alzheimer's disease}},
  journal = {Alzheimer's research \& therapy},
  year    = {2021},
  doi     = {10.1186/s13195-021-00791-x},
  pmid    = {33676561},
  url     = {https://doi.org/10.1186/s13195-021-00791-x}
}

@article{zheng2021-33548579,
  author  = {Zheng, Y. and Zhang, J. and Zhao, Y. and Zhang, Y. and Zhang, X. and Guan, J. and Liu, Y. and Fu, J.},
  title   = {{Curcumin protects against cognitive impairments in a rat model of chronic cerebral hypoperfusion combined with diabetes mellitus by suppressing neuroinflammation, apoptosis, and pyroptosis}},
  journal = {International immunopharmacology},
  year    = {2021},
  doi     = {10.1016/j.intimp.2021.107422},
  pmid    = {33548579},
  url     = {https://doi.org/10.1016/j.intimp.2021.107422}
}

@article{lanzillotta2021-33516914,
  author  = {Lanzillotta, C. and Tramutola, A. and Di Giacomo, G. and Marini, F. and Butterfield, D. A. and Di Domenico, F. and Perluigi, M. and Barone, E.},
  title   = {{Insulin resistance, oxidative stress and mitochondrial defects in Ts65dn mice brain: A harmful synergistic path in down syndrome}},
  journal = {Free radical biology \& medicine},
  year    = {2021},
  doi     = {10.1016/j.freeradbiomed.2021.01.042},
  pmid    = {33516914},
  url     = {https://doi.org/10.1016/j.freeradbiomed.2021.01.042}
}

@article{jagdale2021-33481554,
  author  = {Jagdale, Abhijit and Kumar, Vineeta and Anderson, Douglas J. and Locke, Jayme E. and Hanaway, Michael J. and Eckhoff, Devin E. and Iwase, Hayato and Cooper, David K.C.},
  title   = {{Suggested Patient Selection Criteria for Initial Clinical Trials of Pig Kidney Xenotransplantation in the United States}},
  journal = {Transplantation},
  year    = {2021},
  doi     = {10.1097/tp.0000000000003632},
  pmid    = {33481554},
  url     = {https://doi.org/10.1097/tp.0000000000003632}
}

@article{weng2021-33486152,
  author  = {Weng, Y. and Wang, H. and Li, L. and Feng, Y. and Xu, S. and Wang, Z.},
  title   = {{Trem2 mediated Syk-dependent ROS amplification is essential for osteoclastogenesis in periodontitis microenvironment}},
  journal = {Redox biology},
  year    = {2021},
  doi     = {10.1016/j.redox.2020.101849},
  pmid    = {33486152},
  url     = {https://doi.org/10.1016/j.redox.2020.101849}
}

@article{hallroberts2020-33198789,
  author  = {Hall-Roberts, H. and Agarwal, D. and Obst, J. and Smith, T. B. and Monzón-Sandoval, J. and Di Daniel, E. and Webber, C. and James, W. S. and others},
  title   = {{TREM2 Alzheimer's variant R47H causes similar transcriptional dysregulation to knockout, yet only subtle functional phenotypes in human iPSC-derived macrophages}},
  journal = {Alzheimer's research \& therapy},
  year    = {2020},
  doi     = {10.1186/s13195-020-00709-z},
  pmid    = {33198789},
  url     = {https://doi.org/10.1186/s13195-020-00709-z}
}

@article{wang2020-33081801,
  author  = {Wang, Y. and Shi, Y. and Huang, Y. and Liu, W. and Cai, G. and Huang, S. and Zeng, Y. and Ren, S. and others},
  title   = {{Resveratrol mediates mechanical allodynia through modulating inflammatory response via the TREM2-autophagy axis in SNI rat model}},
  journal = {Journal of neuroinflammation},
  year    = {2020},
  doi     = {10.1186/s12974-020-01991-2},
  pmid    = {33081801},
  url     = {https://doi.org/10.1186/s12974-020-01991-2}
}

@article{kim2020-33008094,
  author  = {Kim, R. E. and Shin, C. Y. and Han, S. H. and Kwon, K. J.},
  title   = {{Astaxanthin Suppresses PM2.5-Induced Neuroinflammation by Regulating Akt Phosphorylation in BV-2 Microglial Cells}},
  journal = {International journal of molecular sciences},
  year    = {2020},
  doi     = {10.3390/ijms21197227},
  pmid    = {33008094},
  url     = {https://doi.org/10.3390/ijms21197227}
}

@article{wang2020-33015803,
  author  = {Wang, X. X. and Zhang, B. and Xia, R. and Jia, Q. Y.},
  title   = {{Inflammation, apoptosis and autophagy as critical players in vascular dementia}},
  journal = {European review for medical and pharmacological sciences},
  year    = {2020},
  doi     = {10.26355/eurrev_202009_23048},
  pmid    = {33015803},
  url     = {https://doi.org/10.26355/eurrev_202009_23048}
}

@article{floresdorantes2020-32982666,
  author  = {Flores-Dorantes, M. T. and Díaz-López, Y. E. and Gutiérrez-Aguilar, R.},
  title   = {{Environment and Gene Association With Obesity and Their Impact on Neurodegenerative and Neurodevelopmental Diseases}},
  journal = {Frontiers in neuroscience},
  year    = {2020},
  doi     = {10.3389/fnins.2020.00863},
  pmid    = {32982666},
  url     = {https://doi.org/10.3389/fnins.2020.00863}
}

@article{perluigi2020-32839417,
  author  = {Perluigi, M. and Tramutola, A. and Pagnotta, S. and Barone, E. and Butterfield, D. A.},
  title   = {{The BACH1/Nrf2 Axis in Brain in Down Syndrome and Transition to Alzheimer Disease-Like Neuropathology and Dementia}},
  journal = {Antioxidants (Basel, Switzerland)},
  year    = {2020},
  doi     = {10.3390/antiox9090779},
  pmid    = {32839417},
  url     = {https://doi.org/10.3390/antiox9090779}
}

@article{jahangard2020-32625049,
  author  = {Jahangard, Y. and Monfared, H. and Moradi, A. and Zare, M. and Mirnajafi-Zadeh, J. and Mowla, S. J.},
  title   = {{Therapeutic Effects of Transplanted Exosomes Containing miR-29b to a Rat Model of Alzheimer's Disease}},
  journal = {Frontiers in neuroscience},
  year    = {2020},
  doi     = {10.3389/fnins.2020.00564},
  pmid    = {32625049},
  url     = {https://doi.org/10.3389/fnins.2020.00564}
}

@article{zhu2020-32401783,
  author  = {Zhu, Z. and Zhang, X. and Dong, W. and Wang, X. and He, S. and Zhang, H. and Wei, R. and others},
  title   = {{TREM2 suppresses the proinflammatory response to facilitate PRRSV infection via PI3K/NF-κB signaling}},
  journal = {PLoS pathogens},
  year    = {2020},
  doi     = {10.1371/journal.ppat.1008543},
  pmid    = {32401783},
  url     = {https://doi.org/10.1371/journal.ppat.1008543}
}

@article{guan2020-32413556,
  author  = {Guan, Y. F. and Huang, G. B. and Xu, M. D. and Gao, F. and Lin, S. and Huang, J. and Wang, J. and Li, Y. Q. and others},
  title   = {{Anti-depression effects of ketogenic diet are mediated via the restoration of microglial activation and neuronal excitability in the lateral habenula}},
  journal = {Brain, behavior, and immunity},
  year    = {2020},
  doi     = {10.1016/j.bbi.2020.05.032},
  pmid    = {32413556},
  url     = {https://doi.org/10.1016/j.bbi.2020.05.032}
}

@article{liu2019-31477129,
  author  = {Liu, C. and Li, P. and Li, H. and Wang, S. and Ding, L. and Wang, H. and Ye, H. and Jin, Y. and others},
  title   = {{TREM2 regulates obesity-induced insulin resistance via adipose tissue remodeling in mice of high-fat feeding}},
  journal = {Journal of translational medicine},
  year    = {2019},
  doi     = {10.1186/s12967-019-2050-9},
  pmid    = {31477129},
  url     = {https://doi.org/10.1186/s12967-019-2050-9}
}

@article{mayeli2019-31305887,
  author  = {Mayeli, M. and Mirshahvalad, S. M. and Aghamollaii, V. and Tafakhori, A. and Abdolalizadeh, A. and Rahmani, F. and {Alzheimer's Disease Neuroimaging Initiative}},
  title   = {{Plasma Neurofilament Light Chain Levels Are Associated With Cortical Hypometabolism in Alzheimer Disease Signature Regions}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2019},
  doi     = {10.1093/jnen/nlz054},
  pmid    = {31305887},
  url     = {https://doi.org/10.1093/jnen/nlz054}
}

@article{guo2019-31370707,
  author  = {Guo, Y. and Wei, X. and Yan, H. and Qin, Y. and Yan, S. and Liu, J. and Zhao, Y. and Jiang, F. and others},
  title   = {{TREM2 deficiency aggravates α-synuclein-induced neurodegeneration and neuroinflammation in Parkinson's disease models}},
  journal = {FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year    = {2019},
  doi     = {10.1096/fj.201900992r},
  pmid    = {31370707},
  url     = {https://doi.org/10.1096/fj.201900992r}
}

@article{anderson2019-31091440,
  author  = {Anderson, SR. and Roberts, J. M. and Zhang, J. and Steele, M. R. and Romero, C. O. and Bosco, A. and Vetter, M. L.},
  title   = {{Developmental Apoptosis Promotes a Disease-Related Gene Signature and Independence from CSF1R Signaling in Retinal Microglia}},
  journal = {Cell reports},
  year    = {2019},
  doi     = {10.1016/j.celrep.2019.04.062},
  pmid    = {31091440},
  url     = {https://doi.org/10.1016/j.celrep.2019.04.062}
}

@article{seitz2018-29899084,
  author  = {Seitz, S. and Clarke, P. and Tyler, K. L.},
  title   = {{Pharmacologic Depletion of Microglia Increases Viral Load in the Brain and Enhances Mortality in Murine Models of Flavivirus-Induced Encephalitis}},
  journal = {Journal of virology},
  year    = {2018},
  doi     = {10.1128/jvi.00525-18},
  pmid    = {29899084},
  url     = {https://doi.org/10.1128/jvi.00525-18}
}

@article{zhao2018-29637444,
  author  = {Zhao, Y. and Lukiw, W. J.},
  title   = {{Bacteroidetes Neurotoxins and Inflammatory Neurodegeneration}},
  journal = {Molecular neurobiology},
  year    = {2018},
  doi     = {10.1007/s12035-018-1015-y},
  pmid    = {29637444},
  url     = {https://doi.org/10.1007/s12035-018-1015-y}
}

@article{karpenko2018-29478949,
  author  = {Karpenko, M. N. and Vasilishina, A. A. and Gromova, E. A. and Muruzheva, Z. M. and Miliukhina, IV. and Bernadotte, A.},
  title   = {{Interleukin-1β, interleukin-1 receptor antagonist, interleukin-6, interleukin-10, and tumor necrosis factor-α levels in CSF and serum in relation to the clinical diversity of Parkinson's disease}},
  journal = {Cellular immunology},
  year    = {2018},
  doi     = {10.1016/j.cellimm.2018.02.011},
  pmid    = {29478949},
  url     = {https://doi.org/10.1016/j.cellimm.2018.02.011}
}

@article{ren2018-29407460,
  author  = {Ren, M. and Guo, Y. and Wei, X. and Yan, S. and Qin, Y. and Zhang, X. and Jiang, F. and Lou, H.},
  title   = {{TREM2 overexpression attenuates neuroinflammation and protects dopaminergic neurons in experimental models of Parkinson's disease}},
  journal = {Experimental neurology},
  year    = {2018},
  doi     = {10.1016/j.expneurol.2018.01.016},
  pmid    = {29407460},
  url     = {https://doi.org/10.1016/j.expneurol.2018.01.016}
}

@article{ventura2017-29259496,
  author  = {Ventura, M. T. and Casciaro, M. and Gangemi, S. and Buquicchio, R.},
  title   = {{Immunosenescence in aging: between immune cells depletion and cytokines up-regulation}},
  journal = {Clinical and molecular allergy : CMA},
  year    = {2017},
  doi     = {10.1186/s12948-017-0077-0},
  pmid    = {29259496},
  url     = {https://doi.org/10.1186/s12948-017-0077-0}
}

@article{wirths2017-28978359,
  author  = {Wirths, O. and Walter, S. and Kraus, I. and Klafki, H. W. and Stazi, M. and Oberstein, T. J. and Ghiso, J. and Wiltfang, J. and others},
  title   = {{N-truncated Aβ4-x peptides in sporadic Alzheimer's disease cases and transgenic Alzheimer mouse models}},
  journal = {Alzheimer's research \& therapy},
  year    = {2017},
  doi     = {10.1186/s13195-017-0309-z},
  pmid    = {28978359},
  url     = {https://doi.org/10.1186/s13195-017-0309-z}
}

@article{sosa2017-28677143,
  author  = {Sosa, L. J. and Cáceres, A. and Dupraz, S. and Oksdath, M. and Quiroga, S. and Lorenzo, A.},
  title   = {{The physiological role of the amyloid precursor protein as an adhesion molecule in the developing nervous system}},
  journal = {Journal of neurochemistry},
  year    = {2017},
  doi     = {10.1111/jnc.14122},
  pmid    = {28677143},
  url     = {https://doi.org/10.1111/jnc.14122}
}

@article{pinto2017-28567000,
  author  = {Pinto, S. and Cunha, C. and Barbosa, M. and Vaz, A. R. and Brites, D.},
  title   = {{Exosomes from NSC-34 Cells Transfected with hSOD1-G93A Are Enriched in miR-124 and Drive Alterations in Microglia Phenotype}},
  journal = {Frontiers in neuroscience},
  year    = {2017},
  doi     = {10.3389/fnins.2017.00273},
  pmid    = {28567000},
  url     = {https://doi.org/10.3389/fnins.2017.00273}
}

@article{yao2017-28330719,
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  title   = {{Nicotinamide mononucleotide inhibits JNK activation to reverse Alzheimer disease}},
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  title   = {{Polyubiquitinylation Profile in Down Syndrome Brain Before and After the Development of Alzheimer Neuropathology}},
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  title   = {{Eating behavior in frontotemporal dementia: Peripheral hormones vs hypothalamic pathology}},
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  title   = {{Stereotactic brain injection of human umbilical cord blood mesenchymal stem cells in patients with Alzheimer's disease dementia: A phase 1 clinical trial}},
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  year    = {2015},
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  title   = {{Mexico City normal weight children exposed to high concentrations of ambient PM2.5 show high blood leptin and endothelin-1, vitamin D deficiency, and food reward hormone dysregulation versus low pollution controls. Relevance for obesity and Alzheimer disease}},
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@article{elobeid2015-25868149,
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  title   = {{In vivo characterization of chronic traumatic encephalopathy using [F-18]FDDNP PET brain imaging}},
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  title   = {{Mediterranean diet and leukocyte telomere length in a multi-ethnic elderly population}},
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  title   = {{Understanding the broad-spectrum neuroprotective action profile of green tea polyphenols in aging and neurodegenerative diseases}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2011},
  doi     = {10.3233/jad-2011-101803},
  pmid    = {21368374},
  url     = {https://doi.org/10.3233/jad-2011-101803}
}

@article{wegiel2011-21157379,
  author  = {Wegiel, J. and Kaczmarski, W. and Barua, M. and Kuchna, I. and Nowicki, K. and Wang, K. C. and Yang, S. M. and others},
  title   = {{Link between DYRK1A overexpression and several-fold enhancement of neurofibrillary degeneration with 3-repeat tau protein in Down syndrome}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2011},
  doi     = {10.1097/nen.0b013e318202bfa1},
  pmid    = {21157379},
  url     = {https://doi.org/10.1097/nen.0b013e318202bfa1}
}

@article{wegiel2011-21156028,
  author  = {Wegiel, J. and Gong, C. X. and Hwang, Y. W.},
  title   = {{The role of DYRK1A in neurodegenerative diseases}},
  journal = {The FEBS journal},
  year    = {2011},
  doi     = {10.1111/j.1742-4658.2010.07955.x},
  pmid    = {21156028},
  url     = {https://doi.org/10.1111/j.1742-4658.2010.07955.x}
}

@article{maezawa2011-20971854,
  author  = {Maezawa, I. and Zimin, P. I. and Wulff, H. and Jin, L. W.},
  title   = {{Amyloid-beta protein oligomer at low nanomolar concentrations activates microglia and induces microglial neurotoxicity}},
  journal = {The Journal of biological chemistry},
  year    = {2011},
  doi     = {10.1074/jbc.m110.135244},
  pmid    = {20971854},
  url     = {https://doi.org/10.1074/jbc.m110.135244}
}

@article{hampstead2011-20935339,
  author  = {Hampstead, B. M. and Stringer, A. Y. and Stilla, R. F. and Deshpande, G. and Hu, X. and Moore, A. B. and Sathian, K.},
  title   = {{Activation and effective connectivity changes following explicit-memory training for face-name pairs in patients with mild cognitive impairment: a pilot study}},
  journal = {Neurorehabilitation and neural repair},
  year    = {2011},
  doi     = {10.1177/1545968310382424},
  pmid    = {20935339},
  url     = {https://doi.org/10.1177/1545968310382424}
}

@article{tamboli2010-20876579,
  author  = {Tamboli, I. Y. and Barth, E. and Christian, L. and Siepmann, M. and Kumar, S. and Singh, S. and Tolksdorf, K. and Heneka, M. T. and others},
  title   = {{Statins promote the degradation of extracellular amyloid beta-peptide by microglia via stimulation of exosome-associated insulin-degrading enzyme (IDE) secretion}},
  journal = {The Journal of biological chemistry},
  year    = {2010},
  doi     = {10.1074/jbc.m110.149468},
  pmid    = {20876579},
  url     = {https://doi.org/10.1074/jbc.m110.149468}
}

@article{pietrzik2010-20608755,
  author  = {Pietrzik, K. and Bailey, L. and Shane, B.},
  title   = {{Folic acid and L-5-methyltetrahydrofolate: comparison of clinical pharmacokinetics and pharmacodynamics}},
  journal = {Clinical pharmacokinetics},
  year    = {2010},
  doi     = {10.2165/11532990-000000000-00000},
  pmid    = {20608755},
  url     = {https://doi.org/10.2165/11532990-000000000-00000}
}

@article{yin2010-20667979,
  author  = {Yin, F. and Dumont, M. and Banerjee, R. and Ma, Y. and Li, H. and Lin, M. T. and Beal, M. F. and Nathan, C. and others},
  title   = {{Behavioral deficits and progressive neuropathology in progranulin-deficient mice: a mouse model of frontotemporal dementia}},
  journal = {FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year    = {2010},
  doi     = {10.1096/fj.10-161471},
  pmid    = {20667979},
  url     = {https://doi.org/10.1096/fj.10-161471}
}

@article{park2010-20670674,
  author  = {Park, H. R. and Park, M. and Choi, J. and Park, K. Y. and Chung, H. Y. and Lee, J.},
  title   = {{A high-fat diet impairs neurogenesis: involvement of lipid peroxidation and brain-derived neurotrophic factor}},
  journal = {Neuroscience letters},
  year    = {2010},
  doi     = {10.1016/j.neulet.2010.07.046},
  pmid    = {20670674},
  url     = {https://doi.org/10.1016/j.neulet.2010.07.046}
}

@article{melchior2010-20640189,
  author  = {Melchior, B. and Garcia, A. E. and Hsiung, B. K. and Lo, K. M. and Doose, J. M. and Thrash, J. C. and Stalder, A. K. and Staufenbiel, M. and others},
  title   = {{Dual induction of TREM2 and tolerance-related transcript, Tmem176b, in amyloid transgenic mice: implications for vaccine-based therapies for Alzheimer's disease}},
  journal = {ASN neuro},
  year    = {2010},
  doi     = {10.1042/an20100010},
  pmid    = {20640189},
  url     = {https://doi.org/10.1042/an20100010}
}

@article{apostolova2010-20538372,
  author  = {Apostolova, L. G. and Hwang, K. S. and Andrawis, J. P. and Green, A. E. and Babakchanian, S. and Morra, J. H. and Cummings, J. L. and Toga, A. W. and others},
  title   = {{3D PIB and CSF biomarker associations with hippocampal atrophy in ADNI subjects}},
  journal = {Neurobiology of aging},
  year    = {2010},
  doi     = {10.1016/j.neurobiolaging.2010.05.003},
  pmid    = {20538372},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2010.05.003}
}

@article{groen2010-20494265,
  author  = {Groen, W. and Teluij, M. and Buitelaar, J. and Tendolkar, I.},
  title   = {{Amygdala and hippocampus enlargement during adolescence in autism}},
  journal = {Journal of the American Academy of Child and Adolescent Psychiatry},
  year    = {2010},
  doi     = {10.1016/j.jaac.2009.12.023},
  pmid    = {20494265},
  url     = {https://doi.org/10.1016/j.jaac.2009.12.023}
}

@article{bruno2009-19915485,
  author  = {Bruno, M. A. and Mufson, E. J. and Wuu, J. and Cuello, A. C.},
  title   = {{Increased matrix metalloproteinase 9 activity in mild cognitive impairment}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2009},
  doi     = {10.1097/nen.0b013e3181c22569},
  pmid    = {19915485},
  url     = {https://doi.org/10.1097/nen.0b013e3181c22569}
}

@article{uemura2009-19924286,
  author  = {Uemura, K. and Lill, C. M. and Li, X. and Peters, J. A. and Ivanov, A. and Fan, Z. and DeStrooper, B. and Bacskai, B. J. and others},
  title   = {{Allosteric modulation of PS1/gamma-secretase conformation correlates with amyloid beta(42/40) ratio}},
  journal = {PloS one},
  year    = {2009},
  doi     = {10.1371/journal.pone.0007893},
  pmid    = {19924286},
  url     = {https://doi.org/10.1371/journal.pone.0007893}
}

@article{lee2009-19631409,
  author  = {Lee, M. and Schwab, C. and Yu, S. and McGeer, E. and McGeer, P. L.},
  title   = {{Astrocytes produce the antiinflammatory and neuroprotective agent hydrogen sulfide}},
  journal = {Neurobiology of aging},
  year    = {2009},
  doi     = {10.1016/j.neurobiolaging.2009.06.001},
  pmid    = {19631409},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2009.06.001}
}

@article{marklund2009-19216653,
  author  = {Marklund, N. and Blennow, K. and Zetterberg, H. and Ronne-Engström, E. and Enblad, P. and Hillered, L.},
  title   = {{Monitoring of brain interstitial total tau and beta amyloid proteins by microdialysis in patients with traumatic brain injury}},
  journal = {Journal of neurosurgery},
  year    = {2009},
  doi     = {10.3171/2008.9.jns08584},
  pmid    = {19216653},
  url     = {https://doi.org/10.3171/2008.9.jns08584}
}

@article{bluher2009-19358089,
  author  = {Blüher, M.},
  title   = {{Adipose tissue dysfunction in obesity}},
  journal = {Experimental and clinical endocrinology \& diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association},
  year    = {2009},
  doi     = {10.1055/s-0029-1192044},
  pmid    = {19358089},
  url     = {https://doi.org/10.1055/s-0029-1192044}
}

@article{gralle2009-19336403,
  author  = {Gralle, M. and Botelho, M. G. and Wouters, F. S.},
  title   = {{Neuroprotective secreted amyloid precursor protein acts by disrupting amyloid precursor protein dimers}},
  journal = {The Journal of biological chemistry},
  year    = {2009},
  doi     = {10.1074/jbc.m808755200},
  pmid    = {19336403},
  url     = {https://doi.org/10.1074/jbc.m808755200}
}

@article{mueller2009-19249372,
  author  = {Mueller, S. G. and Laxer, K. D. and Barakos, J. and Cheong, I. and Garcia, P. and Weiner, M. W.},
  title   = {{Widespread neocortical abnormalities in temporal lobe epilepsy with and without mesial sclerosis}},
  journal = {NeuroImage},
  year    = {2009},
  doi     = {10.1016/j.neuroimage.2009.02.020},
  pmid    = {19249372},
  url     = {https://doi.org/10.1016/j.neuroimage.2009.02.020}
}

@article{bruehl2009-19167831,
  author  = {Bruehl, H. and Wolf, O. T. and Convit, A.},
  title   = {{A blunted cortisol awakening response and hippocampal atrophy in type 2 diabetes mellitus}},
  journal = {Psychoneuroendocrinology},
  year    = {2009},
  doi     = {10.1016/j.psyneuen.2008.12.010},
  pmid    = {19167831},
  url     = {https://doi.org/10.1016/j.psyneuen.2008.12.010}
}

@article{belyaev2009-19057576,
  author  = {Belyaev, N. D. and Nalivaeva, N. N. and Makova, N. Z. and Turner, A. J.},
  title   = {{Neprilysin gene expression requires binding of the amyloid precursor protein intracellular domain to its promoter: implications for Alzheimer disease}},
  journal = {EMBO reports},
  year    = {2009},
  doi     = {10.1038/embor.2008.222},
  pmid    = {19057576},
  url     = {https://doi.org/10.1038/embor.2008.222}
}

@article{zhang2008-18952609,
  author  = {Zhang, L. and Bukulin, M. and Kojro, E. and Roth, A. and Metz, V. V. and Fahrenholz, F. and Nawroth, P. P. and Bierhaus, A. and others},
  title   = {{Receptor for advanced glycation end products is subjected to protein ectodomain shedding by metalloproteinases}},
  journal = {The Journal of biological chemistry},
  year    = {2008},
  doi     = {10.1074/jbc.m806948200},
  pmid    = {18952609},
  url     = {https://doi.org/10.1074/jbc.m806948200}
}

@article{kimonis2008-18845250,
  author  = {Kimonis, V. E. and Fulchiero, E. and Vesa, J. and Watts, G.},
  title   = {{VCP disease associated with myopathy, Paget disease of bone and frontotemporal dementia: review of a unique disorder}},
  journal = {Biochimica et biophysica acta},
  year    = {2008},
  doi     = {10.1016/j.bbadis.2008.09.003},
  pmid    = {18845250},
  url     = {https://doi.org/10.1016/j.bbadis.2008.09.003}
}

@article{sotiropoulos2008-18691381,
  author  = {Sotiropoulos, I. and Catania, C. and Riedemann, T. and Fry, J. P. and Breen, K. C. and Michaelidis, T. M. and Almeida, O. F.},
  title   = {{Glucocorticoids trigger Alzheimer disease-like pathobiochemistry in rat neuronal cells expressing human tau}},
  journal = {Journal of neurochemistry},
  year    = {2008},
  doi     = {10.1111/j.1471-4159.2008.05613.x},
  pmid    = {18691381},
  url     = {https://doi.org/10.1111/j.1471-4159.2008.05613.x}
}

@article{foulds2008-18506455,
  author  = {Foulds, P. and McAuley, E. and Gibbons, L. and Davidson, Y. and Pickering-Brown, S. M. and Neary, D. and Snowden, J. S. and Allsop, D. and others},
  title   = {{TDP-43 protein in plasma may index TDP-43 brain pathology in Alzheimer's disease and frontotemporal lobar degeneration}},
  journal = {Acta neuropathologica},
  year    = {2008},
  doi     = {10.1007/s00401-008-0389-8},
  pmid    = {18506455},
  url     = {https://doi.org/10.1007/s00401-008-0389-8}
}

@article{lee2008-18492487,
  author  = {Lee, H. J. and Suk, J. E. and Bae, E. J. and Lee, S. J.},
  title   = {{Clearance and deposition of extracellular alpha-synuclein aggregates in microglia}},
  journal = {Biochemical and biophysical research communications},
  year    = {2008},
  doi     = {10.1016/j.bbrc.2008.05.045},
  pmid    = {18492487},
  url     = {https://doi.org/10.1016/j.bbrc.2008.05.045}
}

@article{bernhardt2008-18554926,
  author  = {Bernhardt, B. C. and Worsley, K. J. and Besson, P. and Concha, L. and Lerch, J. P. and Evans, A. C. and Bernasconi, N.},
  title   = {{Mapping limbic network organization in temporal lobe epilepsy using morphometric correlations: insights on the relation between mesiotemporal connectivity and cortical atrophy}},
  journal = {NeuroImage},
  year    = {2008},
  doi     = {10.1016/j.neuroimage.2008.04.261},
  pmid    = {18554926},
  url     = {https://doi.org/10.1016/j.neuroimage.2008.04.261}
}

@article{martin2008-18431258,
  author  = {Martin, L. J.},
  title   = {{DNA damage and repair: relevance to mechanisms of neurodegeneration}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2008},
  doi     = {10.1097/nen.0b013e31816ff780},
  pmid    = {18431258},
  url     = {https://doi.org/10.1097/nen.0b013e31816ff780}
}

@article{parachikova2008-18258444,
  author  = {Parachikova, A. and Nichol, K. E. and Cotman, C. W.},
  title   = {{Short-term exercise in aged Tg2576 mice alters neuroinflammation and improves cognition}},
  journal = {Neurobiology of disease},
  year    = {2008},
  doi     = {10.1016/j.nbd.2007.12.008},
  pmid    = {18258444},
  url     = {https://doi.org/10.1016/j.nbd.2007.12.008}
}

@article{tweedie2007-17908040,
  author  = {Tweedie, D. and Sambamurti, K. and Greig, N. H.},
  title   = {{TNF-alpha inhibition as a treatment strategy for neurodegenerative disorders: new drug candidates and targets}},
  journal = {Current Alzheimer research},
  year    = {2007},
  doi     = {10.2174/156720507781788873},
  pmid    = {17908040},
  url     = {https://doi.org/10.2174/156720507781788873}
}

@article{marutle2007-17640880,
  author  = {Marutle, A. and Ohmitsu, M. and Nilbratt, M. and Greig, N. H. and Nordberg, A. and Sugaya, K.},
  title   = {{Modulation of human neural stem cell differentiation in Alzheimer (APP23) transgenic mice by phenserine}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2007},
  doi     = {10.1073/pnas.0705346104},
  pmid    = {17640880},
  url     = {https://doi.org/10.1073/pnas.0705346104}
}

@article{yin2007-17556361,
  author  = {Yin, Y. I. and Bassit, B. and Zhu, L. and Yang, X. and Wang, C. and Li, Y. M.},
  title   = {{gamma-Secretase Substrate Concentration Modulates the Abeta42/Abeta40 Ratio: IMPLICATIONS FOR ALZHEIMER DISEASE}},
  journal = {The Journal of biological chemistry},
  year    = {2007},
  doi     = {10.1074/jbc.m704601200},
  pmid    = {17556361},
  url     = {https://doi.org/10.1074/jbc.m704601200}
}

@article{tampellini2007-17468102,
  author  = {Tampellini, D. and Magrané, J. and Takahashi, R. H. and Li, F. and Lin, M. T. and Almeida, C. G. and Gouras, G. K.},
  title   = {{Internalized antibodies to the Abeta domain of APP reduce neuronal Abeta and protect against synaptic alterations}},
  journal = {The Journal of biological chemistry},
  year    = {2007},
  doi     = {10.1074/jbc.m700373200},
  pmid    = {17468102},
  url     = {https://doi.org/10.1074/jbc.m700373200}
}

@article{kuhn2007-17307738,
  author  = {Kuhn, P. H. and Marjaux, E. and Imhof, A. and De Strooper, B. and Haass, C. and Lichtenthaler, S. F.},
  title   = {{Regulated intramembrane proteolysis of the interleukin-1 receptor II by alpha-, beta-, and gamma-secretase}},
  journal = {The Journal of biological chemistry},
  year    = {2007},
  doi     = {10.1074/jbc.m700356200},
  pmid    = {17307738},
  url     = {https://doi.org/10.1074/jbc.m700356200}
}

@article{medina2007-17169528,
  author  = {Medina, K. L. and Schweinsburg, A. D. and Cohen-Zion, M. and Nagel, B. J. and Tapert, S. F.},
  title   = {{Effects of alcohol and combined marijuana and alcohol use during adolescence on hippocampal volume and asymmetry}},
  journal = {Neurotoxicology and teratology},
  year    = {2007},
  doi     = {10.1016/j.ntt.2006.10.010},
  pmid    = {17169528},
  url     = {https://doi.org/10.1016/j.ntt.2006.10.010}
}

@article{klos2006-17159105,
  author  = {Klos, K. J. and Ahlskog, J. E. and Kumar, N. and Cambern, S. and Butz, J. and Burritt, M. and Fealey, R. D. and Cowl, C. T. and others},
  title   = {{Brain metal concentrations in chronic liver failure patients with pallidal T1 MRI hyperintensity}},
  journal = {Neurology},
  year    = {2006},
  doi     = {10.1212/01.wnl.0000247037.37807.76},
  pmid    = {17159105},
  url     = {https://doi.org/10.1212/01.wnl.0000247037.37807.76}
}

@article{rosenmann2006-17030663,
  author  = {Rosenmann, H. and Grigoriadis, N. and Karussis, D. and Boimel, M. and Touloumi, O. and Ovadia, H. and Abramsky, O.},
  title   = {{Tauopathy-like abnormalities and neurologic deficits in mice immunized with neuronal tau protein}},
  journal = {Archives of neurology},
  year    = {2006},
  doi     = {10.1001/archneur.63.10.1459},
  pmid    = {17030663},
  url     = {https://doi.org/10.1001/archneur.63.10.1459}
}

@article{akisaki2006-16506272,
  author  = {Akisaki, T. and Sakurai, T. and Takata, T. and Umegaki, H. and Araki, A. and Mizuno, S. and Tanaka, S. and Ohashi, Y. and others},
  title   = {{Cognitive dysfunction associates with white matter hyperintensities and subcortical atrophy on magnetic resonance imaging of the elderly diabetes mellitus Japanese elderly diabetes intervention trial (J-EDIT)}},
  journal = {Diabetes/metabolism research and reviews},
  year    = {2006},
  doi     = {10.1002/dmrr.632},
  pmid    = {16506272},
  url     = {https://doi.org/10.1002/dmrr.632}
}

@article{veereshwarayya2006-16887805,
  author  = {Veereshwarayya, V. and Kumar, P. and Rosen, K. M. and Mestril, R. and Querfurth, H. W.},
  title   = {{Differential effects of mitochondrial heat shock protein 60 and related molecular chaperones to prevent intracellular beta-amyloid-induced inhibition of complex IV and limit apoptosis}},
  journal = {The Journal of biological chemistry},
  year    = {2006},
  doi     = {10.1074/jbc.m602533200},
  pmid    = {16887805},
  url     = {https://doi.org/10.1074/jbc.m602533200}
}

@article{tolia2006-16844686,
  author  = {Tolia, A. and Chávez-Gutiérrez, L. and De Strooper, B.},
  title   = {{Contribution of presenilin transmembrane domains 6 and 7 to a water-containing cavity in the gamma-secretase complex}},
  journal = {The Journal of biological chemistry},
  year    = {2006},
  doi     = {10.1074/jbc.m604997200},
  pmid    = {16844686},
  url     = {https://doi.org/10.1074/jbc.m604997200}
}

@article{saha2006-16771683,
  author  = {Saha, R. N. and Pahan, K.},
  title   = {{Regulation of inducible nitric oxide synthase gene in glial cells}},
  journal = {Antioxidants \& redox signaling},
  year    = {2006},
  doi     = {10.1089/ars.2006.8.929},
  pmid    = {16771683},
  url     = {https://doi.org/10.1089/ars.2006.8.929}
}

@article{cao2006-16236385,
  author  = {Cao, D. and Fukuchi, K. and Wan, H. and Kim, H. and Li, L.},
  title   = {{Lack of LDL receptor aggravates learning deficits and amyloid deposits in Alzheimer transgenic mice}},
  journal = {Neurobiology of aging},
  year    = {2006},
  doi     = {10.1016/j.neurobiolaging.2005.09.011},
  pmid    = {16236385},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2005.09.011}
}

@article{cruts2005-15888485,
  author  = {Cruts, M. and Rademakers, R. and Gijselinck, I. and van der Zee, J. and Dermaut, B. and de Pooter, T. and de Rijk, P. and Del-Favero, J. and others},
  title   = {{Genomic architecture of human 17q21 linked to frontotemporal dementia uncovers a highly homologous family of low-copy repeats in the tau region}},
  journal = {Human molecular genetics},
  year    = {2005},
  doi     = {10.1093/hmg/ddi182},
  pmid    = {15888485},
  url     = {https://doi.org/10.1093/hmg/ddi182}
}

@article{migliore2005-15708428,
  author  = {Migliore, L. and Fontana, I. and Trippi, F. and Colognato, R. and Coppedè, F. and Tognoni, G. and Nucciarone, B. and Siciliano, G.},
  title   = {{Oxidative DNA damage in peripheral leukocytes of mild cognitive impairment and AD patients}},
  journal = {Neurobiology of aging},
  year    = {2005},
  doi     = {10.1016/j.neurobiolaging.2004.07.016},
  pmid    = {15708428},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2004.07.016}
}

@article{camden2005-15778502,
  author  = {Camden, J. M. and Schrader, A. M. and Camden, R. E. and González, F. A. and Erb, L. and Seye, C. I. and Weisman, G. A.},
  title   = {{P2Y2 nucleotide receptors enhance alpha-secretase-dependent amyloid precursor protein processing}},
  journal = {The Journal of biological chemistry},
  year    = {2005},
  doi     = {10.1074/jbc.m500219200},
  pmid    = {15778502},
  url     = {https://doi.org/10.1074/jbc.m500219200}
}

@article{angeletti2005-15722349,
  author  = {Angeletti, B. and Waldron, K. J. and Freeman, K. B. and Bawagan, H. and Hussain, I. and Miller, C. C. and Lau, K. F. and Tennant, M. E. and others},
  title   = {{BACE1 cytoplasmic domain interacts with the copper chaperone for superoxide dismutase-1 and binds copper}},
  journal = {The Journal of biological chemistry},
  year    = {2005},
  doi     = {10.1074/jbc.m412034200},
  pmid    = {15722349},
  url     = {https://doi.org/10.1074/jbc.m412034200}
}

@article{martin2005-15734684,
  author  = {Martin, G. M.},
  title   = {{Genetic modulation of senescent phenotypes in Homo sapiens}},
  journal = {Cell},
  year    = {2005},
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@article{polito2026-41669531,
  author  = {Polito, Cristina and Martinelli, Giulia and Della Bella, Sara and Pavan, Eleonora and Crocetto, Ylenia and Abagnale, Simona and Rondoni, Cristiana and Voscarelli, Alfonso and others},
  title   = {{Integrated bio-cooperative robotic platform for virtual cognitive training in Parkinson's disease: design and methodology of the OPERA project}},
  journal = {Frontiers in Neurology},
  year    = {2026},
  doi     = {10.3389/fneur.2025.1680215},
  pmid    = {41669531},
  url     = {https://doi.org/10.3389/fneur.2025.1680215}
}

@article{satoh2026-41571432,
  author  = {Satoh, Ryota and Ali, Farwa and Dickson, Dennis W. and Lowe, Val J. and Josephs, Keith A. and Whitwell, Jennifer L.},
  title   = {{Subtracting First Principal Component May Improve 4R Tau Detectability on [ 18 F]Flortaucipir Tau PET}},
  journal = {Journal of Nuclear Medicine},
  year    = {2026},
  doi     = {10.2967/jnumed.125.271019},
  pmid    = {41571432},
  url     = {https://doi.org/10.2967/jnumed.125.271019}
}

@article{silvallanes2026-41486173,
  author  = {Silva-Llanes, Ignacio and Smith, Lilia A. and Abdelkader-Guillén, Aaron and Jiménez-Villegas, José and Sarrió, David and Gema, Moreno-Bueno and Lastres‐Becker, Isabel},
  title   = {{GASDERMIN D-mediated pyroptosis as a therapeutic target in TAU-dependent frontotemporal dementia mouse model}},
  journal = {Journal of Biomedical Science},
  year    = {2026},
  doi     = {10.1186/s12929-025-01210-1},
  pmid    = {41486173},
  url     = {https://doi.org/10.1186/s12929-025-01210-1}
}

@article{tsai2026-41516384,
  author  = {Tsai, Hui‐Yun and Qiu, Jing Yi and Liao, Han-Wei and Chang, Chi‐I and Chen, Yu-Hsiang and Ho, Chi‐Tang and Chen, Yu-Kuo and others},
  title   = {{Propyl Gallate Attenuates Methylglyoxal-Induced Alzheimer-like Cognitive Deficits and Neuroinflammation in Mice}},
  journal = {International Journal of Molecular Sciences},
  year    = {2026},
  doi     = {10.3390/ijms27010511},
  pmid    = {41516384},
  url     = {https://doi.org/10.3390/ijms27010511}
}

@article{benussi2026-41700307,
  author  = {Benussi, Alberto and Cantoni, Valentina and Palacino, Federica and Altomare, Daniele and Moretti, Davide Vito and Manganotti, Paolo and Borroni, Barbara},
  title   = {{EEG network reorganization across Alzheimer's disease, frontotemporal dementia, and dementia with Lewy bodies}},
  journal = {Alzheimer s \& Dementia Diagnosis Assessment \& Disease Monitoring},
  year    = {2026},
  doi     = {10.1002/dad2.70275},
  pmid    = {41700307},
  url     = {https://doi.org/10.1002/dad2.70275}
}

@article{white2026-41546756,
  author  = {White, Matthew A. and Crowley, Leon and Massenzio, Francesca and Li, Xingli and Niblock, Michael and Milani, Sara and Coleman, Michael P. and Barmada, Sami J. and others},
  title   = {{Inhibiting Glycogen Synthase Kinase 3 Suppresses TDP-43-Mediated Neurotoxicity in a Caspase-Dependent Manner}},
  journal = {Molecular Neurobiology},
  year    = {2026},
  doi     = {10.1007/s12035-026-05675-5},
  pmid    = {41546756},
  url     = {https://doi.org/10.1007/s12035-026-05675-5}
}

@article{mason2025-41388643,
  author  = {Mason, Andrew C. and Fatih, Nasri and Sofat, Reecha and Rentsch, Christopher T. and Smeeth, Liam L and Bhaskaran, Krishnan and Chaturvedi, Nish and Garfield, Victoria},
  title   = {{Disentangling the relationship between glucose, insulin and brain health: A UK Biobank study}},
  journal = {Diabetes Obesity and Metabolism},
  year    = {2025},
  doi     = {10.1111/dom.70353},
  pmid    = {41388643},
  url     = {https://doi.org/10.1111/dom.70353}
}

@article{conti2025-41348997,
  author  = {Conti, Matteo and Mascioli, Davide and Simonetta, Clara and Ferrari, Valerio and Bissacco, Jacopo and Bagetta, Silvio and Carparelli, Federico and Bernardini, Sergio and others},
  title   = {{Clinical, Biological, and Functional Connectivity Profile of Patients With De Novo Parkinson Disease Who Are APOE ε4 Carriers}},
  journal = {Neurology},
  year    = {2025},
  doi     = {10.1212/wnl.0000000000214449},
  pmid    = {41348997},
  url     = {https://doi.org/10.1212/wnl.0000000000214449}
}

@article{norgren2025-41434470,
  author  = {Norgren, Jakob and Carballo‐Casla, Adrián and Börjesson‐Hanson, Anne and Eriksdotter, Maria and Laukka, Erika J and Ptacek, Sara Garcia},
  title   = {{APOE‐Genotype Modifies the Association of Meat Consumption with Cognitive Decline: Longitudinal Analyses of The Swedish National Study on Aging and Care, SNAC‐K}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70860_107412},
  pmid    = {41434470},
  url     = {https://doi.org/10.1002/alz70860_107412}
}

@article{kusiak2025-41447596,
  author  = {Kusiak, Coco M and Mak-McCully, Rachel A. and Murray, Carolyn and Walsh, Jonathan R.},
  title   = {{Leveraging digital twins for sample size reduction, powering secondary endpoints or subgroups in a simulated TRAILBLAZER‐ALZ 2 trial}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70859_101285},
  pmid    = {41447596},
  url     = {https://doi.org/10.1002/alz70859_101285}
}

@article{rehra2025-41187812,
  author  = {Rehra, Lena and Erdinger, Susanne and Wagner, Lelia and Baltissen, Danny and Just, Jennifer and König, Leo and Mühlberg, Eric and Eisenzapf, Tom and others},
  title   = {{Brain delivery of a neurotrophic peptide derived from secreted amyloid precursor protein APPsα as a therapeutic strategy for Alzheimer's disease}},
  journal = {Journal of Controlled Release},
  year    = {2025},
  doi     = {10.1016/j.jconrel.2025.114374},
  pmid    = {41187812},
  url     = {https://doi.org/10.1016/j.jconrel.2025.114374}
}

@article{li2025-40967343,
  author  = {Li, Kai and Bian, Yueyan and Xing, Yi and Jia, Xiuqin},
  title   = {{Altered glymphatic function and cerebrovascular reactivity in white matter hyperintensities: Insights into cognitive impairment}},
  journal = {Brain Research Bulletin},
  year    = {2025},
  doi     = {10.1016/j.brainresbull.2025.111552},
  pmid    = {40967343},
  url     = {https://doi.org/10.1016/j.brainresbull.2025.111552}
}

@article{sandhof2025-40851193,
  author  = {Sandhof, Carl Alexander and Martin, Nicole and Tittelmeier, Jessica and Schlueter, Annabelle and Pezzali, Martina and Schoendorf, David C. and Lange, Timo and Reinhardt, Peter P. and others},
  title   = {{A novel C. elegans model for MAPT/Tau spreading reveals genes critical for endolysosomal integrity and seeded MAPT/Tau aggregation}},
  journal = {Autophagy},
  year    = {2025},
  doi     = {10.1080/15548627.2025.2551676},
  pmid    = {40851193},
  url     = {https://doi.org/10.1080/15548627.2025.2551676}
}

@article{mitterova2025-40849483,
  author  = {Mitterová, Kristína and Výtvarová, Eva and Kovářová, Anežka and Lamoš, Martin and Fousek, Jan and Rektorová, Irena},
  title   = {{Early functional changes in lewy body dementia: roles of dynamics, locus coeruleus, and compensation}},
  journal = {Alzheimer s Research \& Therapy},
  year    = {2025},
  doi     = {10.1186/s13195-025-01828-1},
  pmid    = {40849483},
  url     = {https://doi.org/10.1186/s13195-025-01828-1}
}

@article{yu2025-f0768c81,
  author  = {Yu, Jun and Zhang, Yuzhou and Ho, Mary T. and Kam, Ka Wai and Rong, Shi Song and Young, Alvin Lerrmann and Pang, Chi Pui and Tham, Clement Chee Yung and others},
  title   = {{Integrated Roles of Systemic Diseases and Serum Biomarkers in the Incidence of Age‐Related Macular Degeneration: The UK Biobank Study}},
  journal = {Medicine Bulletin},
  year    = {2025},
  doi     = {10.1002/mdb2.70008},
  url     = {https://doi.org/10.1002/mdb2.70008}
}

@article{prinse2025-40754329,
  author  = {Prinse, F. A. M. and van der Weerd, L. and van Swieten, J. C. and Ronen, I. and Seelaar, H. and Hirschler, L. and Najac, C. and Dopper, E. G. P.},
  title   = {{Investigating the role of neuroinflammation and brain clearance in frontotemporal lobar degeneration using 7T MRI and fluid biomarkers: protocol for a cross-sectional study in a tertiary care setting}},
  journal = {BMJ open},
  year    = {2025},
  doi     = {10.1136/bmjopen-2025-102668},
  pmid    = {40754329},
  url     = {https://doi.org/10.1136/bmjopen-2025-102668}
}

@article{beharry2025-40794874,
  author  = {Beharry, Aruun and Ward, Cian and Moore, Henry and Hoffman, Kyle S. and Chan, Patricia P. and Lowe, Todd M. and O’Donoghue, Patrick},
  title   = {{High-fidelity and differential nonsense suppression in live cells and a frontotemporal dementia allele with human transfer RNAs}},
  journal = {Nucleic Acids Research},
  year    = {2025},
  doi     = {10.1093/nar/gkaf730},
  pmid    = {40794874},
  url     = {https://doi.org/10.1093/nar/gkaf730}
}

@article{lanzillotta2025-40684658,
  author  = {Lanzillotta, C. and Prestia, F. and Greco, V. and Iavarone, F. and Cordella, F. and Sette, C. and Forte, E. and Tramutola, A. and others},
  title   = {{Enhancing protein O-GlcNAcylation in down syndrome mice mitigates memory dysfunctions through the rescue of mitochondrial bioenergetics, stress responses and pathological markers}},
  journal = {Redox biology},
  year    = {2025},
  doi     = {10.1016/j.redox.2025.103769},
  pmid    = {40684658},
  url     = {https://doi.org/10.1016/j.redox.2025.103769}
}

@article{chen2025-40588144,
  author  = {Chen, Dongmei and Li, Ruomeng and She, Fei and Chen, Jiawen and Cho, Sang Min and Yang, Bohyun and Tian, Yuan and Guan, Le and others},
  title   = {{Saikosaponin C ameliorates tau-related pathology by modulating oxidative stress and MAPK axis in Alzheimer's disease}},
  journal = {Journal of Ethnopharmacology},
  year    = {2025},
  doi     = {10.1016/j.jep.2025.120221},
  pmid    = {40588144},
  url     = {https://doi.org/10.1016/j.jep.2025.120221}
}

@article{devkota2025-40723827,
  author  = {Devkota, Sujan and Maesako, Masato and Wolfe, Michael S.},
  title   = {{Presenilin-1 Familial Alzheimer Mutations Impair γ-Secretase Cleavage of APP Through Stabilized Enzyme–Substrate Complex Formation}},
  journal = {Biomolecules},
  year    = {2025},
  doi     = {10.3390/biom15070955},
  pmid    = {40723827},
  url     = {https://doi.org/10.3390/biom15070955}
}

@article{choi2025-40592207,
  author  = {Choi, Jae-Won and Im, Joo Young and Balakrishnan, Rengasamy},
  title   = {{Paeoniflorin exercise-mimetic potential regulates the Nrf2/HO-1/BDNF/CREB and APP/BACE-1/NF-κB/MAPK signaling pathways to reduce cognitive impairments and neuroinflammation in amnesic mouse model}},
  journal = {Biomedicine \& Pharmacotherapy},
  year    = {2025},
  doi     = {10.1016/j.biopha.2025.118299},
  pmid    = {40592207},
  url     = {https://doi.org/10.1016/j.biopha.2025.118299}
}

@article{carra2025-40398193,
  author  = {Carra, Serena and Fábián, Balázs and Taghavi, Hamed Vaez and Milanetti, Edoardo and Giliberti, Valeria and Ruocco, Giancarlo and Shepherd, Jason D. and Vendruscolo, Michele and others},
  title   = {{Virus-like particles of retroviral origin in protein aggregation and neurodegenerative diseases}},
  journal = {Molecular Aspects of Medicine},
  year    = {2025},
  doi     = {10.1016/j.mam.2025.101369},
  pmid    = {40398193},
  url     = {https://doi.org/10.1016/j.mam.2025.101369}
}

@article{ali2025-40336141,
  author  = {Ali, Muhammad and Garcia, Pierre and Lunkes, Laetitia P. and Sciortino, Alessia and Thomas, Mélanie H. and Heurtaux, Tony and Grzyb, Kamil and Halder, Rashi and others},
  title   = {{Temporal transcriptomic changes in the THY-Tau22 mouse model of tauopathy display cell type- and sex-specific differences}},
  journal = {Acta Neuropathologica Communications},
  year    = {2025},
  doi     = {10.1186/s40478-025-02013-z},
  pmid    = {40336141},
  url     = {https://doi.org/10.1186/s40478-025-02013-z}
}

@article{du2025-40320714,
  author  = {Du, Fang Ling and Yu, Qing and Hu, Gang and Lin, Chyuan‐Sheng and Yan, Shirley ShiDu},
  title   = {{PINK1-dependent NFKB signaling contributes to amyloid pathology in Alzheimer disease}},
  journal = {Autophagy},
  year    = {2025},
  doi     = {10.1080/15548627.2025.2463322},
  pmid    = {40320714},
  url     = {https://doi.org/10.1080/15548627.2025.2463322}
}

@article{xu2025-40248881,
  author  = {Xu, Xiangming and Yi, Ming and Xiao, Chi and Yang, Jing and Guo, Jiayu and Zhou, Wenli and Zhou, Kun and Hu, Liuting and others},
  title   = {{IGF-1 Provides Protective Role in Arteriosclerotic Cerebral Small Vessel Disease}},
  journal = {Hypertension},
  year    = {2025},
  doi     = {10.1161/hypertensionaha.124.24341},
  pmid    = {40248881},
  url     = {https://doi.org/10.1161/hypertensionaha.124.24341}
}

@article{kaurani2025-40216778,
  author  = {Kaurani, Lalit and Pradhan, Ranjit and Schröder, Sophie and Burkhardt, Susanne and Schuetz, Anna-Lena and Krüger, Dennis Manfred and Centeno, Tonatiuh Peña and Heutink, Peter and others},
  title   = {{A role for astrocytic miR-129-5p in frontotemporal dementia}},
  journal = {Translational Psychiatry},
  year    = {2025},
  doi     = {10.1038/s41398-025-03338-y},
  pmid    = {40216778},
  url     = {https://doi.org/10.1038/s41398-025-03338-y}
}

@article{cunningham2025-40172482,
  author  = {Cunningham, Mauro César Quintão e Silva and Camargos, Sarah and Jeunon, Vinícius Ribeiro and Rocha, Natália Pessoa and Teixeira, Antônio Lúcio and Maciel, Thiago de Oliveira and Resende, Elisa de Paula França and Cardoso, Francisco and others},
  title   = {{Does Midbrain Atrophy Distinguish Progressive Supranuclear Palsy from Frontotemporal Dementia?}},
  journal = {Movement Disorders Clinical Practice},
  year    = {2025},
  doi     = {10.1002/mdc3.70058},
  pmid    = {40172482},
  url     = {https://doi.org/10.1002/mdc3.70058}
}

@article{ylmaz2025-40699631,
  author  = {Yılmaz, Habibe and Bayraktutan, Ulvi},
  title   = {{Cerebral Small Vessel Disease: Therapeutic Approaches Targeting Neuroinflammation, Oxidative Stress, and Endothelial Dysfunction}},
  journal = {Current Issues in Molecular Biology},
  year    = {2025},
  doi     = {10.3390/cimb47040232},
  pmid    = {40699631},
  url     = {https://doi.org/10.3390/cimb47040232}
}

@article{lee2025-40243457,
  author  = {Lee, Pei-Hua and Huang, Shao-Min and Tsai, Yi-Ching and Wang, Yu-Ting and Chew, Fatt Yang},
  title   = {{Biomarkers in Contrast-Induced Nephropathy: Advances in Early Detection, Risk Assessment, and Prevention Strategies}},
  journal = {International Journal of Molecular Sciences},
  year    = {2025},
  doi     = {10.3390/ijms26072869},
  pmid    = {40243457},
  url     = {https://doi.org/10.3390/ijms26072869}
}

@article{beckers2025-40395983,
  author  = {Beckers, Jimmy and Van Damme, Philip},
  title   = {{The role of autophagy in the pathogenesis and treatment of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD)}},
  journal = {Autophagy Reports},
  year    = {2025},
  doi     = {10.1080/27694127.2025.2474796},
  pmid    = {40395983},
  url     = {https://doi.org/10.1080/27694127.2025.2474796}
}

@article{yang2025-40045356,
  author  = {Yang, Qu and Chen, Qi and Zhang, Kai-Bing and Liu, Yu and Zheng, Jia-Cheng and Hu, Dong-Xia and Luo, Jun},
  title   = {{Sinomenine alleviates neuroinflammation in chronic cerebral hypoperfusion by promoting M2 microglial polarization and inhibiting neuronal pyroptosis via exosomal miRNA-223-3p}},
  journal = {Acta Neuropathologica Communications},
  year    = {2025},
  doi     = {10.1186/s40478-025-01950-z},
  pmid    = {40045356},
  url     = {https://doi.org/10.1186/s40478-025-01950-z}
}

@article{dohl2025-40042516,
  author  = {Dohl, J. and Treadwell, Z. and Norris, C. and Head, E.},
  title   = {{Calcineurin inhibition may prevent Alzheimer disease in people with Down syndrome}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2025},
  doi     = {10.1002/alz.70034},
  pmid    = {40042516},
  url     = {https://doi.org/10.1002/alz.70034}
}

@article{huyghe2025-40400392,
  author  = {Huyghe, Lara and Quenon, Lisa and Salman, Yasmine and Colmant, Lise and Gérard, Thomas and Malotaux, Vincent and Boyer, Emilien and Dricot, Laurence and others},
  title   = {{Entorhinal tau impairs short-term memory binding in preclinical Alzheimer’s disease}},
  journal = {Journal of the International Neuropsychological Society},
  year    = {2025},
  doi     = {10.1017/s1355617725000165},
  pmid    = {40400392},
  url     = {https://doi.org/10.1017/s1355617725000165}
}

@article{tandoro2025-39939643,
  author  = {Tandoro, Yohanes and Chiu, Hui‐Fang and Tan, Chei-Ling and Hsieh, Ming‐Hong and Huang, Yi‐Wen and Yu, Jianhua and Wang, Li‐Shu and Chan, Chi‐Ho and others},
  title   = {{Black raspberry supplementation on overweight and Helicobacter pylori infected mild dementia patients a pilot study}},
  journal = {npj Science of Food},
  year    = {2025},
  doi     = {10.1038/s41538-024-00356-w},
  pmid    = {39939643},
  url     = {https://doi.org/10.1038/s41538-024-00356-w}
}

@article{zhang2025-39929674,
  author  = {Zhang, Fan and Yu, Xiaomei and Tian, Yimei and Zeng, Jia and Zhuang, Pan and Jia, Wei and Zhang, Yu},
  title   = {{Joint control of multiple food processing contaminants in Maillard reaction: A comprehensive review of health risks and prevention}},
  journal = {Comprehensive Reviews in Food Science and Food Safety},
  year    = {2025},
  doi     = {10.1111/1541-4337.70138},
  pmid    = {39929674},
  url     = {https://doi.org/10.1111/1541-4337.70138}
}

@article{xu2025-39936244,
  author  = {Xu, Ziming and Ji, Yong Il and Chen, Wen and Gan, Jinghuan and Chen, Zhichao and Li, Rui and Lin, Xiaoqi and Dou, Jiaqi and others},
  title   = {{Tracer kinetic model detecting heterogeneous blood–brain barrier permeability to water and contrast agent in Alzheimer's disease and dementia with Lewy bodies}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz.14529},
  pmid    = {39936244},
  url     = {https://doi.org/10.1002/alz.14529}
}

@article{rui2025-39853966,
  author  = {Rui, Tongyu and Huang, He‐Zhou and Zheng, Kai and Fan, Hong‐Wei and Zhang, Juan and Guo, Ziyuan and Man, Heng‐Ye and Brazhe, Nadezda A. and others},
  title   = {{Tau Pathology Drives Disease‐Associated Astrocyte Reactivity in Salt‐Induced Neurodegeneration}},
  journal = {Advanced Science},
  year    = {2025},
  doi     = {10.1002/advs.202410799},
  pmid    = {39853966},
  url     = {https://doi.org/10.1002/advs.202410799}
}

@article{bernhard2025-39826021,
  author  = {Bernhard, Johannes and Galli, Lukas and Speidl, Walter Stefan and Krychtiuk, Konstantin Alexander},
  title   = {{Cardiovascular Risk Reduction in Metabolic Dysfunction-Associated Steatotic Liver Disease and Metabolic Dysfunction-Associated Steatohepatitis}},
  journal = {Current Cardiology Reports},
  year    = {2025},
  doi     = {10.1007/s11886-024-02185-5},
  pmid    = {39826021},
  url     = {https://doi.org/10.1007/s11886-024-02185-5}
}

@article{shen2025-39813987,
  author  = {Shen, Hongtao and Xie, Yuying and Wang, Yan and Xie, Yusheng and Wang, Yongxiang and Su, Zhenyan and Zhao, Laixi and Yao, Shi and others},
  title   = {{The ER protein CANX (calnexin)-mediated autophagy protects against alzheimer disease}},
  journal = {Autophagy},
  year    = {2025},
  doi     = {10.1080/15548627.2024.2447206},
  pmid    = {39813987},
  url     = {https://doi.org/10.1080/15548627.2024.2447206}
}

@article{fine2025-39872995,
  author  = {Fine, Jared M. and Kosyakovsky, Jacob and Bowe, Tate T. and Faltesek, Katherine A. and STROEBEL, BENJAMIN M. and Abrahante, Juan E. and Kelly, Michael Robert and Thompson, Elizabeth A. and others},
  title   = {{Low-dose intranasal deferoxamine modulates memory, neuroinflammation, and the neuronal transcriptome in the streptozotocin rodent model of Alzheimer’s disease}},
  journal = {Frontiers in Neuroscience},
  year    = {2025},
  doi     = {10.3389/fnins.2024.1528374},
  pmid    = {39872995},
  url     = {https://doi.org/10.3389/fnins.2024.1528374}
}

@article{wang2025-39755599,
  author  = {Wang, Jie and Zhang, Mengqing and Wei, Xiaomei and Yang, Cheng and Dai, Meng and Dou, Zulin and Wang, Yonghui},
  title   = {{Effects of intermittent theta burst stimulation on cognitive and swallowing function in patients with MCI and dysphagia risk: a randomized controlled trial}},
  journal = {BMC Geriatrics},
  year    = {2025},
  doi     = {10.1186/s12877-024-05625-7},
  pmid    = {39755599},
  url     = {https://doi.org/10.1186/s12877-024-05625-7}
}

@article{kaur2024-39136022,
  author  = {Kaur, S. and Sharma, K. and Sharma, A. and Sandha, K. K. and Ali, S. M. and Ahmed, R. and Ramajayan, P. and Singh, P. P. and others},
  title   = {{Fluvoxamine maleate alleviates amyloid-beta load and neuroinflammation in 5XFAD mice to ameliorate Alzheimer disease pathology}},
  journal = {Frontiers in immunology},
  year    = {2024},
  doi     = {10.3389/fimmu.2024.1418422},
  pmid    = {39136022},
  url     = {https://doi.org/10.3389/fimmu.2024.1418422}
}

@article{antoine2023-37984835,
  author  = {Antoine, Lisa H. and Tanner, Jared J. and Mickle, Angela M. and Gonzalez, Cesar E. and Kusko, Daniel A. and Allen-Watts, Kristen and Rumble, Deanna and Buchanan, Taylor and others},
  title   = {{Greater socioenvironmental risk factors and higher chronic pain stage are associated with thinner bilateral temporal lobes}},
  journal = {Brain and Behavior},
  year    = {2023},
  doi     = {10.1002/brb3.3330},
  pmid    = {37984835},
  url     = {https://doi.org/10.1002/brb3.3330}
}

@article{rahhal2023-37662495,
  author  = {Rahhal, S. and Farmer, C. and Thurm, A. and Wassif, C. A. and Cawley, N. X. and Perreault, J. and Dang Do, A. and Bianconi, S. and others},
  title   = {{Elevated amyloid beta peptides and total tau in cerebrospinal fluid in individuals with Creatine transporter deficiency}},
  journal = {Molecular genetics and metabolism reports},
  year    = {2023},
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@article{admati2023-37572658,
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  title   = {{Two distinct molecular faces of preeclampsia revealed by single-cell transcriptomics}},
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@article{he2022-36316319,
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  title   = {{The Hong Kong Grocery Shopping Dialog Task (HK-GSDT): A Quick Screening Test for Neurocognitive Disorders}},
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@article{bajaj2022-35537854,
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  title   = {{Area Deprivation Index and Gut-Brain Axis in Cirrhosis}},
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@article{neri2022-35596580,
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  title   = {{Epilepsy in neurodegenerative diseases}},
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@article{si2021-34386016,
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  journal = {Frontiers in immunology},
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@article{crews2021-33611821,
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@article{kalayc2021-33155700,
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@article{wu2022-35224156,
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  title   = {{“Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene-dose-sensitive AD-suppressor in human brain”}},
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  title   = {{Age and Sex Influence the Neuro-inflammatory Response to a Peripheral Acute LPS Challenge}},
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@article{gervois2019-31379859,
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@article{ladak2019-31301445,
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@article{sheng2019-31219699,
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@article{fu2019-31066686,
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  title   = {{Natural Language Processing for the Identification of Silent Brain Infarcts From Neuroimaging Reports}},
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@article{chalatsa2019-30971876,
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  title   = {{The Crocus sativus Compounds trans-Crocin 4 and trans-Crocetin Modulate the Amyloidogenic Pathway and Tau Misprocessing in Alzheimer Disease Neuronal Cell Culture Models}},
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@article{zhou2019-30756214,
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@article{tang2019-30683932,
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  title   = {{TREM2 acts as a tumor suppressor in hepatocellular carcinoma by targeting the PI3K/Akt/β-catenin pathway}},
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@article{mukherjee2019-30733664,
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  title   = {{A Microglial Signature Directing Human Aging and Neurodegeneration-Related Gene Networks}},
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  title   = {{Baseline Performance Predicts tDCS-Mediated Improvements in Language Symptoms in Primary Progressive Aphasia}},
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  title   = {{An intranasally delivered peptide drug ameliorates cognitive decline in Alzheimer transgenic mice}},
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  title   = {{Phenotypic Screening Identifies Modulators of Amyloid Precursor Protein Processing in Human Stem Cell Models of Alzheimer's Disease}},
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@article{trudler2014-24355073,
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  title   = {{γ-Secretase associated with lipid rafts: multiple interactive pathways in the stepwise processing of β-carboxyl-terminal fragment}},
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  year    = {2014},
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  title   = {{Intracerebroventricular streptozotocin exacerbates Alzheimer-like changes of 3xTg-AD mice}},
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@article{cheng2013-23546882,
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  journal = {The Journal of biological chemistry},
  year    = {2013},
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@article{oneill2013-23470275,
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@article{nagao2012-23026537,
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  title   = {{Progressive supranuclear palsy presenting as primary lateral sclerosis but lacking parkinsonism, gaze palsy, aphasia, or dementia}},
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@article{fisette2012-22303960,
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  year    = {2012},
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@article{young2012-22155432,
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  title   = {{Putting proteins in their place: palmitoylation in Huntington disease and other neuropsychiatric diseases}},
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  year    = {2012},
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@article{guo2012-22144675,
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  title   = {{Amyloid precursor protein revisited: neuron-specific expression and highly stable nature of soluble derivatives}},
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  year    = {2012},
  doi     = {10.1074/jbc.m111.315051},
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@article{landt2011-21403005,
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  title   = {{Using positron emission tomography and Carbon 11-labeled Pittsburgh Compound B to image Brain Fibrillar β-amyloid in adults with down syndrome: safety, acceptability, and feasibility}},
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  year    = {2011},
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@article{mei2010-20813165,
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  journal = {Neuroscience},
  year    = {2010},
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@article{lefterov2010-20739292,
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  title   = {{Apolipoprotein A-I deficiency increases cerebral amyloid angiopathy and cognitive deficits in APP/PS1DeltaE9 mice}},
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  year    = {2010},
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@article{lee2010-20595668,
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  title   = {{Vascular and degenerative processes differentially affect regional interhemispheric connections in normal aging, mild cognitive impairment, and Alzheimer disease}},
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@article{liang2010-20595388,
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  year    = {2010},
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@article{desmaele2010-20380821,
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@article{venkataramani2010-20145244,
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  title   = {{Histone deacetylase inhibitor valproic acid inhibits cancer cell proliferation via down-regulation of the alzheimer amyloid precursor protein}},
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@article{kolla2010-19902006,
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  year    = {2010},
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@article{porayette2009-19542221,
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  title   = {{Differential processing of amyloid-beta precursor protein directs human embryonic stem cell proliferation and differentiation into neuronal precursor cells}},
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@article{sarsoza2009-19360426,
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  year    = {2009},
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@article{lukiw2008-19022980,
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@article{sitz2008-18938227,
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  title   = {{The Down syndrome candidate dual-specificity tyrosine phosphorylation-regulated kinase 1A phosphorylates the neurodegeneration-related septin 4}},
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  year    = {2008},
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  pmid    = {18938227},
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@article{matos2008-18790019,
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  title   = {{Amyloid-beta peptide decreases glutamate uptake in cultured astrocytes: involvement of oxidative stress and mitogen-activated protein kinase cascades}},
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  year    = {2008},
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  pmid    = {18790019},
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@article{ringman2008-18332257,
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  title   = {{Mosaicism for trisomy 21 in a patient with young-onset dementia: a case report and brief literature review}},
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  year    = {2008},
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  pmid    = {18332257},
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@article{mandel2008-19040558,
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  title   = {{Simultaneous manipulation of multiple brain targets by green tea catechins: a potential neuroprotective strategy for Alzheimer and Parkinson diseases}},
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  year    = {2008},
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  pmid    = {19040558},
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@article{cheon2008-18163181,
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  title   = {{Protein expression of BACE1, BACE2 and APP in Down syndrome brains}},
  journal = {Amino acids},
  year    = {2008},
  doi     = {10.1007/s00726-007-0618-9},
  pmid    = {18163181},
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@article{flanary2007-17378753,
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@article{medhurst2007-17327487,
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  title   = {{GSK189254, a novel H3 receptor antagonist that binds to histamine H3 receptors in Alzheimer's disease brain and improves cognitive performance in preclinical models}},
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  year    = {2007},
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@article{mehta2007-17275850,
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  year    = {2007},
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@article{carlson2007-17546681,
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  title   = {{Perinatal iron deficiency results in altered developmental expression of genes mediating energy metabolism and neuronal morphogenesis in hippocampus}},
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  year    = {2007},
  doi     = {10.1002/hipo.20307},
  pmid    = {17546681},
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@article{muller2007-17093061,
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  title   = {{Modulation of gene expression and cytoskeletal dynamics by the amyloid precursor protein intracellular domain (AICD)}},
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  doi     = {10.1091/mbc.e06-04-0283},
  pmid    = {17093061},
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@article{haltia2006-16908122,
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  title   = {{The neuronal ceroid-lipofuscinoses: from past to present}},
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  year    = {2006},
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  pmid    = {16908122},
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@article{bendszus2006-16545753,
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  year    = {2006},
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  pmid    = {16545753},
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@article{hussein2006-16562856,
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  title   = {{Astaxanthin, a carotenoid with potential in human health and nutrition}},
  journal = {Journal of natural products},
  year    = {2006},
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  pmid    = {16562856},
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@article{moreira2006-16432155,
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  title   = {{Brain and brawn: parallels in oxidative strength}},
  journal = {Neurology},
  year    = {2006},
  doi     = {10.1212/01.wnl.0000192307.15103.83},
  pmid    = {16432155},
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@article{omuro2005-16216945,
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  title   = {{Delayed neurotoxicity in primary central nervous system lymphoma}},
  journal = {Archives of neurology},
  year    = {2005},
  doi     = {10.1001/archneur.62.10.1595},
  pmid    = {16216945},
  url     = {https://doi.org/10.1001/archneur.62.10.1595}
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@article{hatters2005-16076841,
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  title   = {{Modulation of apolipoprotein E structure by domain interaction: differences in lipid-bound and lipid-free forms}},
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  title   = {{Microglial histone H3K18 crotonylation promotes STAT1 expression and induces cognitive deficit in Alzheimer disease}},
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  title   = {{Aldehyde-Mediated Neurotoxicity and Lutein Intervention: A Novel Therapeutic Strategy for Alzheimer's Disease}},
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@article{chen2026-42411051,
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@article{zhang2025-41421073,
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@article{neupane2025-41465242,
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  title   = {{Molecular Crossroads: Shared and Divergent Molecular Signatures in Alzheimer’s Disease and Dementia with Lewy Bodies}},
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@article{carbonell2025-41447351,
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  title   = {{Tau is associated with atrophy in MCI independently of beta‐amyloid and APOE e4 genotype}},
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@article{flores2025-41447668,
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  title   = {{Comparing Off‐Target Meningeal and Skull Signal in Head‐to‐Head MK‐6240 and AV‐1451 Tau PET}},
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  pmid    = {41447668},
  url     = {https://doi.org/10.1002/alz70856_101657}
}

@article{robinson2025-41443270,
  author  = {Robinson, Carling G. and Binette, Alexa Pichet and Horie, Kanta and Sato, Chihiro and Schindler, Suzanne Elizabeth and Barthélemy, Nicolas R. and Bateman, Randall John and Benzinger, Tammie L.S. and others},
  title   = {{Associations between tau PET and CSF MTBR243 do not vary by sex}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70856_098213},
  pmid    = {41443270},
  url     = {https://doi.org/10.1002/alz70856_098213}
}

@article{halder2025-41326481,
  author  = {Halder, Debojyoti and Banerjee, Suvankar and Biswas, Swati and Adhikari, Nilanjan and Ghosh, Balaram},
  title   = {{Molecular modeling to simulation: insights into Gaussian QSAR, molecular docking, and DFT for identification of HDAC3 inhibitors for neurocognitive vascular dementia}},
  journal = {Scientific Reports},
  year    = {2025},
  doi     = {10.1038/s41598-025-28304-y},
  pmid    = {41326481},
  url     = {https://doi.org/10.1038/s41598-025-28304-y}
}

@article{lin2025-41404035,
  author  = {Lin, Zihao and Li, Yangdanyu and Liu, Yuning and Yang, Bo and Yin, Peixiao and Guan, Chenyang and Fang, Yating and Yang, Liying and others},
  title   = {{Alterations in gut microbiota and plasma metabolites: a multi-omics study of mild cognitive impairment in Parkinson’s disease}},
  journal = {Frontiers in Neuroscience},
  year    = {2025},
  doi     = {10.3389/fnins.2025.1667331},
  pmid    = {41404035},
  url     = {https://doi.org/10.3389/fnins.2025.1667331}
}

@article{garciagonzalez2025-41447255,
  author  = {García‐González, Pablo and Puerta, Raquel and Dehairs, Jonas and de Rojas, Itziar and Montrreal, Laura and Marquié, Marta and Rosende‐Roca, Maitée and Emon, Asif Imran and others},
  title   = {{Integrative multi‐omics analysis reveals physiological and genetic drivers of CSF biomarker variability: implications in neurodegeneration studies}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70856_099623},
  pmid    = {41447255},
  url     = {https://doi.org/10.1002/alz70856_099623}
}

@article{dellarole2025-41399249,
  author  = {Dellarole, Ilaria Linda and Aprea, Vittoria and Catania, Marcella and Battipaglia, Claudia and Romeo, Aurora and Villa, Cristina and Burato, Anna and Celauro, Luigi and others},
  title   = {{Detection of TDP‐43 seeds in CSF of presymptomatic and symptomatic genetic FTD/ALS}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz.70989},
  pmid    = {41399249},
  url     = {https://doi.org/10.1002/alz.70989}
}

@article{ferrarisouza2025-41449556,
  author  = {Ferrari‐Souza, João Pedro and Povala, Guilherme and Rahmouni, Nesrine and Bellaver, Bruna and Ferreira, Pâmela C.L. and Leffa, Douglas Teixeira and Lussier, Firoza Zubeida and Aguzzoli, Cristiano Schaffer and others},
  title   = {{Microglia as a key player in Aβ‐related astrocyte reactivity}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70856_102677},
  pmid    = {41449556},
  url     = {https://doi.org/10.1002/alz70856_102677}
}

@article{raeesi2025-41399254,
  author  = {Raeesi, Shima and Zeighami, Yashar and Moqadam, Roqaie and Morrison, Cassandra and Dadar, Mahsa},
  title   = {{Vascular risk factors mediate the relationship between education and white matter hyperintensities}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz.70972},
  pmid    = {41399254},
  url     = {https://doi.org/10.1002/alz.70972}
}

@article{ji2025-41249845,
  author  = {Ji, Jeff X. and Giles, Brian L. and Bhattacharjee, Surjyadipta and Kautzmann, Marie-Audrey Ines and Masson, Alasdair P. and Carmo, Sonia Do and Cuello, A. Claudio and Bazan, Nicolas Guillermo},
  title   = {{Intercellular signaling and synaptic deconstruction uncovered by single-cell and spatial transcriptomics in an AD tauopathy model}},
  journal = {Communications Biology},
  year    = {2025},
  doi     = {10.1038/s42003-025-08959-z},
  pmid    = {41249845},
  url     = {https://doi.org/10.1038/s42003-025-08959-z}
}

@article{zhao2025-41198459,
  author  = {Zhao, Huimin and Li, Fangjie and Xu, Sheng and Du, Yanan and Chen, Peipei and Wei, Jie and Hao, Kun and Liu, Xiaoquan and others},
  title   = {{Restoration neurite growth by removing the blockage of endosome trafficking in Alzheimer-like mice}},
  journal = {Neurotherapeutics},
  year    = {2025},
  doi     = {10.1016/j.neurot.2025.e00777},
  pmid    = {41198459},
  url     = {https://doi.org/10.1016/j.neurot.2025.e00777}
}

@article{tchuisseukwangoua2025-41182006,
  author  = {Tchuisseu‐Kwangoua, Larissa Ange and Omarov, Murad and Shatunov, Aleksey and Markus, Hugh Stephen and Tatuene, Joseph Kamtchum and Georgakis, Marios K.},
  title   = {{Genetic Downregulation of Interleukin‐6 Signaling and Arteriolosclerotic Cerebral Small Vessel Disease: A Drug Target Mendelian Randomization Analysis}},
  journal = {Journal of the American Heart Association},
  year    = {2025},
  doi     = {10.1161/jaha.124.041814},
  pmid    = {41182006},
  url     = {https://doi.org/10.1161/jaha.124.041814}
}

@article{crans2025-7fc8ca4a,
  author  = {Crans, R. A. J. and Fructuoso, M. and Cardozo, K. B. and Recaioglu, H. and Fonseca, J. S. and Vermeiren, Y. and Strydom, A. and Dam, D. V. and others},
  title   = {{Common pathogenic mechanisms in the hippocampus across neurodegenerative dementias: Alzheimer's disease, Down syndrome, and Parkinson's disease}},
  journal = {NPJ dementia},
  year    = {2025},
  doi     = {10.21203/rs.3.rs-7703742/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-7703742/v1}
}

@article{bruno2025-40986437,
  author  = {Bruno, Davide and Plaska, Chelsea Reichert and Zinkunegi, Ainara Jauregi and Ashton, Nicholas J. and Zetterberg, Henrik and Blennow, Kaj and Pomara, Nunzio},
  title   = {{Associations of plasma p‐tau231 with serial position recall performance in free‐of‐dementia individuals}},
  journal = {Journal of Neuropsychology},
  year    = {2025},
  doi     = {10.1111/jnp.70012},
  pmid    = {40986437},
  url     = {https://doi.org/10.1111/jnp.70012}
}

@article{zeng2025-40816274,
  author  = {Zeng, Peng-Ming and Sun, Xin-Yao and Li, Yang and Wu, Wen-di and Huang, Jing and Cao, Dongdong and Qian, Pin-jue and Ju, Xiang-Chun and others},
  title   = {{Thymosin beta 4 as an Alzheimer disease intervention target identified using human brain organoids}},
  journal = {Stem Cell Reports},
  year    = {2025},
  doi     = {10.1016/j.stemcr.2025.102601},
  pmid    = {40816274},
  url     = {https://doi.org/10.1016/j.stemcr.2025.102601}
}

@article{fornage2025-40750903,
  author  = {Fornage, Myriam and Tarraf, Wassim and Daviglus, Martha L. and DeCarli, Charles S and González, Kevin A. and Isasi, Carmen R. and Kuwayama, Sayaka and Lamar, Melissa and others},
  title   = {{Association of epigenetic aging with plasma biomarkers of amyloid, tau, neurodegeneration, and neuroinflammation in Hispanic/Latino adults}},
  journal = {Clinical Epigenetics},
  year    = {2025},
  doi     = {10.1186/s13148-025-01941-w},
  pmid    = {40750903},
  url     = {https://doi.org/10.1186/s13148-025-01941-w}
}

@article{miedema2025-40713859,
  author  = {Miedema, Suzanne S. M. and Rajicic, Ana and Mol, Merel O. and Paliukhovich, Iryna and Klaassen, Remco V. and van Buuren, Renee and Li, Ka Wan and Koopmans, Frank and others},
  title   = {{Proteomics of the temporal cortex in semantic dementia reveals brain-region specific molecular pathology and regulation of the TDP-43-ANXA11 interactome}},
  journal = {Acta Neuropathologica Communications},
  year    = {2025},
  doi     = {10.1186/s40478-025-02077-x},
  pmid    = {40713859},
  url     = {https://doi.org/10.1186/s40478-025-02077-x}
}

@article{ueno2025-40675920,
  author  = {Ueno, Asako and Hamano, Tadanori and Nagata, Miwako and Yamaguchi, Tomohisa and Endo, Yoshinori and Enomoto, Soichi and Kimura, Hirohiko and Ikawa, Masamichi and others},
  title   = {{Association of vitamin B12 deficiency in a dementia cohort with hippocampal atrophy on MRI}},
  journal = {The Journal of Prevention of Alzheimer s Disease},
  year    = {2025},
  doi     = {10.1016/j.tjpad.2025.100265},
  pmid    = {40675920},
  url     = {https://doi.org/10.1016/j.tjpad.2025.100265}
}

@article{dematteis2025-40615914,
  author  = {Dematteis, Giulia and Gong, Chunmei and Malecka, Justyna and Tonelli, Elisa and Genazzani, Armando A. and Tapella, Laura and Eleuteri, Anna Maria and Lim, Dmitry and others},
  title   = {{Rescue of protein dyshomeostasis in hippocampal astrocytes from an Alzheimer’s disease mouse model by stabilizing ER-mitochondrial interactions at a 20 nm distance}},
  journal = {Alzheimer s Research \& Therapy},
  year    = {2025},
  doi     = {10.1186/s13195-025-01793-9},
  pmid    = {40615914},
  url     = {https://doi.org/10.1186/s13195-025-01793-9}
}

@article{watanabe2025-40677151,
  author  = {Watanabe, Ryohei and Papatriantafyllou, John D. and Maeda, Kengo and Aguirre, Geoffrey K. and Ando, Masahiro and Benoit, Bernice M. and Grossman, Murray and Irwin, David John and others},
  title   = {{Clinicopathological characterization of vacuolar tauopathy associated with VCP D395G}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz.70427},
  pmid    = {40677151},
  url     = {https://doi.org/10.1002/alz.70427}
}

@article{akif2025-40462117,
  author  = {Akif, Adnan and Nguyen, T.T. and Liu, Langni and Xu, Xiaotian and Kulkarni, Amol A. and Jiang, Jianxiong and Zhang, Yang and Hao, Jiukuan},
  title   = {{Targeting NLRP3 signaling with a novel sulfonylurea compound for the treatment of vascular cognitive impairment and dementia}},
  journal = {Fluids and Barriers of the CNS},
  year    = {2025},
  doi     = {10.1186/s12987-025-00665-6},
  pmid    = {40462117},
  url     = {https://doi.org/10.1186/s12987-025-00665-6}
}

@article{liao2025-40455292,
  author  = {Liao, Fan and Calvo-Rodríguez, María and Chhaya, Meha and Sefrin, Julian P. and Charych, Erik I. and Mezler, Mario and Clausznitzer, Diana and McGlame, Emily J. and others},
  title   = {{Anti-pyroglutamate-3 Aβ immunotherapy engages microglia and inhibits amyloid accumulation in transgenic mouse models of Aβ amyloidosis}},
  journal = {Acta Neuropathologica},
  year    = {2025},
  doi     = {10.1007/s00401-025-02892-5},
  pmid    = {40455292},
  url     = {https://doi.org/10.1007/s00401-025-02892-5}
}

@article{gan2025-40457423,
  author  = {Gan, Jinghuan and Xu, Ziming and Chen, Wen and Wu, Hao and Chen, Zhichao and Shi, Zhihong and Lu, Hao and Wang, Yajie and others},
  title   = {{Potential role of Amyloid-β on the association between Orexin-A and blood-brain barrier leakage of globus pallidus in Alzheimer’s disease and dementia with lewy bodies}},
  journal = {Alzheimer s Research \& Therapy},
  year    = {2025},
  doi     = {10.1186/s13195-025-01770-2},
  pmid    = {40457423},
  url     = {https://doi.org/10.1186/s13195-025-01770-2}
}

@article{xu2025-40414977,
  author  = {Xu, Yawen and Zhang, Hailing and Jiao, Xuehao and Zhang, Yanbo and Yin, Ge and Wang, Cui and Du, Zengkan and Liang, Meng and others},
  title   = {{Dysregulations of C1QA, C1QB, C1QC and C5AR1 as candidate biomarkers of vascular dementia}},
  journal = {npj Aging},
  year    = {2025},
  doi     = {10.1038/s41514-025-00228-x},
  pmid    = {40414977},
  url     = {https://doi.org/10.1038/s41514-025-00228-x}
}

@article{feng2025-40361183,
  author  = {Feng, Wenjing and Ju, Mengwei and Wang, Tao and Cui, Shanshan and Yang, Kexin and Guo, Zhiting and Liu, Miao and Tao, Jiaxuan and others},
  title   = {{Linking oxysterols and different stages of mild cognitive impairment: insights from gut metabolites and N6-methyladenosine}},
  journal = {Alzheimer s Research \& Therapy},
  year    = {2025},
  doi     = {10.1186/s13195-025-01743-5},
  pmid    = {40361183},
  url     = {https://doi.org/10.1186/s13195-025-01743-5}
}

@article{pagano2025-40362435,
  author  = {Pagano, Lorenzo and Lagrotteria, Davide and Facconi, Alessandro and Saraceno, Claudia and Longobardi, Antonio and Bellini, Sonia and Ingannato, Assunta and Bagnoli, Silvia and others},
  title   = {{Evaluation of Illumina and Oxford Nanopore Sequencing for the Study of DNA Methylation in Alzheimer’s Disease and Frontotemporal Dementia}},
  journal = {International Journal of Molecular Sciences},
  year    = {2025},
  doi     = {10.3390/ijms26094198},
  pmid    = {40362435},
  url     = {https://doi.org/10.3390/ijms26094198}
}

@article{cokdinleyen2025-40430450,
  author  = {Cokdinleyen, Melis and Valdés, Alberto and Kara, Hüseyin and Ibáñez, Elena and Cifuentes, Alejandro},
  title   = {{Neuroprotective Potential of Tetraselmis chuii Compounds: Insights into Blood–Brain Barrier Permeability and Intestinal Transport}},
  journal = {Pharmaceuticals},
  year    = {2025},
  doi     = {10.3390/ph18050629},
  pmid    = {40430450},
  url     = {https://doi.org/10.3390/ph18050629}
}

@article{han2025-40239644,
  author  = {Han, Xudong and Zhang, Yichi and Petrosky, Jillian N and Bald, Sarah and Sherva, Richard and Labadorf, Adam Thomas and Cherry, Jonathan D. and Chung, Jaeyoon and others},
  title   = {{A structural haplotype in the 17q21.31 MAPT region is associated with increased risk for chronic traumatic encephalopathy endophenotypes}},
  journal = {Cell Reports Medicine},
  year    = {2025},
  doi     = {10.1016/j.xcrm.2025.102084},
  pmid    = {40239644},
  url     = {https://doi.org/10.1016/j.xcrm.2025.102084}
}

@article{yoon2025-40277896,
  author  = {Yoon, Chi‐Su},
  title   = {{Natural Products in the Treatment of Neuroinflammation at Microglia: Recent Trend and Features}},
  journal = {Cells},
  year    = {2025},
  doi     = {10.3390/cells14080571},
  pmid    = {40277896},
  url     = {https://doi.org/10.3390/cells14080571}
}

@article{zhai2025-40151913,
  author  = {Zhai, Yanyu and Lu, Kaili and Yuan, Yuan and Zhang, Ziyao and Xue, Lixia and Zhao, Fei and Xu, Xiaofeng and Wang, Hongmei},
  title   = {{Semaglutide improves cognitive function and neuroinflammation in APP/PS1 transgenic mice by activating AMPK and inhibiting TLR4/NF-κB pathway}},
  journal = {Journal of Alzheimer s Disease},
  year    = {2025},
  doi     = {10.1177/13872877251329439},
  pmid    = {40151913},
  url     = {https://doi.org/10.1177/13872877251329439}
}

@article{yasin2025-40128451,
  author  = {Yasin, Elham Tahsin and Erturk, Mediha and Taşsöker, Melek and Köklü, Murat},
  title   = {{Automatic mandibular third molar and mandibular canal relationship determination based on deep learning models for preoperative risk reduction}},
  journal = {Clinical Oral Investigations},
  year    = {2025},
  doi     = {10.1007/s00784-025-06285-6},
  pmid    = {40128451},
  url     = {https://doi.org/10.1007/s00784-025-06285-6}
}

@article{sordu2025-40116694,
  author  = {Sordu, Pelin and Alaylıoğlu, Merve and Samancı, Bedia and Bulu, Ersel and Güleç, Zeynep Ece Kaya and Bılgıç, Başar and Hanagasi, Hasmet Ayhan and Gurvit, Hakan I. and others},
  title   = {{Cerebrospinal fluid HSP90AA1, HSPA4, and STUB1/CHIP levels in Alzheimer's disease, mild cognitive impairment, and frontotemporal dementia}},
  journal = {Journal of Alzheimer s Disease},
  year    = {2025},
  doi     = {10.1177/13872877251329540},
  pmid    = {40116694},
  url     = {https://doi.org/10.1177/13872877251329540}
}

@article{moran2025-40119105,
  author  = {Moran, Katie L. and Smith, Craig J. and McManus, Elizabeth and Allan, Stuart McRae and Montaldi, Daniela and Muhlert, Nils},
  title   = {{Cerebrovascular health impacts processing speed through anterior white matter alterations: a UK biobank study}},
  journal = {Scientific Reports},
  year    = {2025},
  doi     = {10.1038/s41598-025-93399-2},
  pmid    = {40119105},
  url     = {https://doi.org/10.1038/s41598-025-93399-2}
}

@article{zheng2025-40114219,
  author  = {Zheng, Xi and Liu, Xueli and Guo, Yuqian and Lv, Yi and Lin, Chensheng and Wang, Dan and Wang, Shaobing and Liu, Yiping and others},
  title   = {{Physical exercise and epigenetic modifications in skeletal muscle, brain, and heart}},
  journal = {Epigenetics \& Chromatin},
  year    = {2025},
  doi     = {10.1186/s13072-025-00576-8},
  pmid    = {40114219},
  url     = {https://doi.org/10.1186/s13072-025-00576-8}
}

@article{alami2025-40111935,
  author  = {Alami, Mehdi and Zerif, Echarki and Khalil, Abdelouahed and Hajji, Nabil and Ramassamy, Charles and Lacombe, Guy and Laurent, Benoît and Cohen, Alan A. and others},
  title   = {{Neuroprotective effects of SGLT2 inhibitors empagliflozin and dapagliflozin on Aβ 1–42 -induced neurotoxicity and neuroinflammation in cellular models of Alzheimer's disease}},
  journal = {Journal of Alzheimer s Disease},
  year    = {2025},
  doi     = {10.1177/13872877251329474},
  pmid    = {40111935},
  url     = {https://doi.org/10.1177/13872877251329474}
}

@article{silvallanes2025-40081780,
  author  = {Silva-Llanes, Ignacio and Rodríguez-López, Silvia and González-Naranjo, Pedro and del Sastre, Eric and López, Manuela G. and Paez, Juan Antonio and Campillo, Nuria Eugenia and Lastres‐Becker, Isabel},
  title   = {{Targeting CB2 receptor with a novel antagonist reverses cognitive decline, neurodegeneration and pyroptosis in a TAU-dependent frontotemporal dementia mouse model}},
  journal = {Brain Behavior and Immunity},
  year    = {2025},
  doi     = {10.1016/j.bbi.2025.03.008},
  pmid    = {40081780},
  url     = {https://doi.org/10.1016/j.bbi.2025.03.008}
}

@article{pereira2025-40036368,
  author  = {Pereira, Pedro Ervilha and De Bleecker, Jan and Bogaert, Elke and Dermaut, Bart},
  title   = {{Myopathic aggregation-prone variants in the TDP-43 prion-like domain: genetics paving the way}},
  journal = {Brain},
  year    = {2025},
  doi     = {10.1093/brain/awaf076},
  pmid    = {40036368},
  url     = {https://doi.org/10.1093/brain/awaf076}
}

@article{jakalski2025-39998604,
  author  = {Jąkalski, Marcin and Bruhn‐Olszewska, Bożena and Rychlicka-Buniowska, Edyta and Davies, Hanna and Sarkisyan, Daniil and Siedlar, Maciej and Baran, Jarosław and Węglarczyk, Kazimierz and others},
  title   = {{DNA methylation patterns contribute to changes of cellular differentiation pathways in leukocytes with LOY from patients with Alzheimer´s disease}},
  journal = {Cellular and Molecular Life Sciences},
  year    = {2025},
  doi     = {10.1007/s00018-025-05618-8},
  pmid    = {39998604},
  url     = {https://doi.org/10.1007/s00018-025-05618-8}
}

@article{lovdal2025-39964544,
  author  = {Lövdal, Sofie and van Veen, Rick and Carli, Giulia and Renken, Remco J. and Shiner, Tamara and Bregman, Noa and Orad, Rotem Iris and Arnaldi, Dario and others},
  title   = {{IRMA: Machine learning-based harmonization of \$\$^18\$\$F-FDG PET brain scans in multi-center studies}},
  journal = {European Journal of Nuclear Medicine and Molecular Imaging},
  year    = {2025},
  doi     = {10.1007/s00259-025-07114-4},
  pmid    = {39964544},
  url     = {https://doi.org/10.1007/s00259-025-07114-4}
}

@article{talaat2025-39966086,
  author  = {Talaat, Aya N. and Ibrahim, Nehal and Ayoub, Iriny M. and Labib, Rola Milad and Singab, Abdel Nasser B.},
  title   = {{Gas Chromatography‐Mass Spectrometry Profiling of Crateva magna Leaf Lipophilic Extract and Evaluation of Its Anti‐Alzheimer and Cytotoxic Properties}},
  journal = {Chemistry \& Biodiversity},
  year    = {2025},
  doi     = {10.1002/cbdv.202402770},
  pmid    = {39966086},
  url     = {https://doi.org/10.1002/cbdv.202402770}
}

@article{zhang2025-39923958,
  author  = {Zhang, Han and Bi, F.H. Tra and Zhao, Peng and Cui, Herong and Tao, Xiaojun and Zhang, Jianghua and Li, Chang and Cao, Yang and others},
  title   = {{Longan Aril polysaccharides ameliorate cognitive impairment in AD mice via restoration of the immune phagocytosis of microglia}},
  journal = {Journal of Ethnopharmacology},
  year    = {2025},
  doi     = {10.1016/j.jep.2025.119464},
  pmid    = {39923958},
  url     = {https://doi.org/10.1016/j.jep.2025.119464}
}

@article{cai2025-40012224,
  author  = {Cai, Huaying and Zhang, Nan and Jiang, Yun and Wu, Qianwen and Ni, Linhui and Han, Guocan and Liaocheng, Jiaao and Wu, Dan and others},
  title   = {{State-dependent functional network connectivity alterations in post-stroke dementia with subcortical lesions}},
  journal = {Journal of Alzheimer s Disease},
  year    = {2025},
  doi     = {10.1177/13872877241313056},
  pmid    = {40012224},
  url     = {https://doi.org/10.1177/13872877241313056}
}

@article{counts2025-40008917,
  author  = {Counts, Scott and Beck, John Swanson and Maloney, Bryan J. and Malek‐Ahmadi, Michael H. and Ginsberg, Stephen D. and Mufson, Elliott Jay and Lahiri, Debomoy K.},
  title   = {{Posterior cingulate cortex microRNA dysregulation differentiates cognitive resilience, mild cognitive impairment, and Alzheimer's disease}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz.70019},
  pmid    = {40008917},
  url     = {https://doi.org/10.1002/alz.70019}
}

@article{aljarba2025-39892578,
  author  = {Aljarba, Nada Hamad and Al-Kuraishy, Hayder Mutter and Al-Gareeb, Ali Ismail and Shokr, Mustafa M and Papadakis, Marios and Alexiou, Athanasios T. and Alruwaili, Mubarak and Alrouji, Mohammed and others},
  title   = {{The possible therapeutic role of advanced glycation end-product inhibitors in ischemic stroke}},
  journal = {Brain Research Bulletin},
  year    = {2025},
  doi     = {10.1016/j.brainresbull.2025.111236},
  pmid    = {39892578},
  url     = {https://doi.org/10.1016/j.brainresbull.2025.111236}
}

@article{cartee2025-39864627,
  author  = {Cartee, Naw May Pearl and Lee, Soo Jung and Wu, Emily and Sukpraphrute, Richard and Sukpraphrute, Catherine and Greenbaum, Jolie and Wang, Michael M.},
  title   = {{Light-chain split luciferase assay implicates pathological NOTCH3 thiol reactivity in inherited cerebral small vessel disease}},
  journal = {Journal of Biological Chemistry},
  year    = {2025},
  doi     = {10.1016/j.jbc.2025.108224},
  pmid    = {39864627},
  url     = {https://doi.org/10.1016/j.jbc.2025.108224}
}

@article{schievink2025-39848780,
  author  = {Schievink, Wouter I. and Maya, M. Marcel and Saouaf, Rola and LIPSHUTZ, HERBERT and Taché, Rachelle B. and Scoffings, Daniel J. and Schmahmann, Jeremy Dan},
  title   = {{Azygos Vein Stenosis in Frontotemporal Dementia Sagging Brain Syndrome}},
  journal = {American Journal of Neuroradiology},
  year    = {2025},
  doi     = {10.3174/ajnr.a8532},
  pmid    = {39848780},
  url     = {https://doi.org/10.3174/ajnr.a8532}
}

@article{zhu2025-39842821,
  author  = {Zhu, Sanyong and Song, Zhenfeng and Tapayan, April Sweet and Singh, Kartikey and Wang, Kuang‐Wei and Hagar, Hsiao‐Tien Chien and Zhang, Jicheng and Kim, Hyunbae and others},
  title   = {{Effects of Heparan Sulfate Trisaccharide Containing Oleanolic Acid in Attenuating Hyperphosphorylated Tau-Induced Cell Dysfunction Associated with Alzheimer’s Disease}},
  journal = {Journal of Medicinal Chemistry},
  year    = {2025},
  doi     = {10.1021/acs.jmedchem.4c02563},
  pmid    = {39842821},
  url     = {https://doi.org/10.1021/acs.jmedchem.4c02563}
}

@article{saks2025-39840612,
  author  = {Saks, Danit and Sachdev, Perminder Singh},
  title   = {{Monogenic causes of cerebral small vessel disease- models for vascular cognitive impairment and dementia?}},
  journal = {Current Opinion in Psychiatry},
  year    = {2025},
  doi     = {10.1097/yco.0000000000000978},
  pmid    = {39840612},
  url     = {https://doi.org/10.1097/yco.0000000000000978}
}

@article{coles2025-40226383,
  author  = {Coles, Nathan P. and Elsheikh, Suzan and Quesnel, Agathe and Butler, Lucy and Achadu, Ojodomo J. and Islam, Meez and Kalesh, Karunakaran and Occhipinti, Annalisa and others},
  title   = {{Alpha-synuclein aggregation induces prominent cellular lipid changes as revealed by Raman spectroscopy and machine learning analysis}},
  journal = {Brain Communications},
  year    = {2025},
  doi     = {10.1093/braincomms/fcaf133},
  pmid    = {40226383},
  url     = {https://doi.org/10.1093/braincomms/fcaf133}
}

@article{matyi2025-40716388,
  author  = {Matyi, Melanie A. and Radhakrishnan, Hamsanandini and Olm, Christopher A. and Phillips, Jeffrey S. and Cook, Philip A. and Rhodes, Emma and Gee, James C. and Irwin, David John and others},
  title   = {{Executive dysfunction relates to salience network desegregation in behavioural variant frontotemporal dementia}},
  journal = {NeuroImage Clinical},
  year    = {2025},
  doi     = {10.1016/j.nicl.2025.103853},
  pmid    = {40716388},
  url     = {https://doi.org/10.1016/j.nicl.2025.103853}
}

@article{thomas2025-41210610,
  author  = {Thomas, Sarah T and Palanikumar, Logesh and Darby, David and Brodtmann, Amy G.},
  title   = {{FDG-PET anterior cingulate cortex hypometabolism as a marker of cerebral small vessel disease in Alzheimer's and vascular cognitive impairment and dementia}},
  journal = {Cerebral Circulation - Cognition and Behavior},
  year    = {2025},
  doi     = {10.1016/j.cccb.2025.100404},
  pmid    = {41210610},
  url     = {https://doi.org/10.1016/j.cccb.2025.100404}
}

@article{brennan2024-38865485,
  author  = {Brennan, F. H. and Swarts, E. A. and Kigerl, K. A. and Mifflin, K. A. and Guan, Z. and Noble, B. T. and Wang, Y. and Witcher, K. G. and others},
  title   = {{Microglia promote maladaptive plasticity in autonomic circuitry after spinal cord injury in mice}},
  journal = {Science translational medicine},
  year    = {2024},
  doi     = {10.1126/scitranslmed.adi3259},
  pmid    = {38865485},
  url     = {https://doi.org/10.1126/scitranslmed.adi3259}
}

@article{seddighi2024-38277467,
  author  = {Seddighi, S. and Qi, Y. A. and Brown, A. L. and Wilkins, O. G. and Bereda, C. and Belair, C. and Zhang, Y. J. and Prudencio, M. and others},
  title   = {{Mis-spliced transcripts generate de novo proteins in TDP-43-related ALS/FTD}},
  journal = {Science translational medicine},
  year    = {2024},
  doi     = {10.1126/scitranslmed.adg7162},
  pmid    = {38277467},
  url     = {https://doi.org/10.1126/scitranslmed.adg7162}
}

@article{ross2024-38287652,
  author  = {Ross, F. C. and Mayer, D. E. and Horn, J. and Cryan, J. F. and Del Rio, D. and Randolph, E. and Gill, C. I. R. and Gupta, A. and others},
  title   = {{Potential of dietary polyphenols for protection from age-related decline and neurodegeneration: a role for gut microbiota?}},
  journal = {Nutritional neuroscience},
  year    = {2024},
  doi     = {10.1080/1028415x.2023.2298098},
  pmid    = {38287652},
  url     = {https://doi.org/10.1080/1028415x.2023.2298098}
}

@article{guzik2024-38172242,
  author  = {Guzik, T. J. and Nosalski, R. and Maffia, P. and Drummond, G. R.},
  title   = {{Immune and inflammatory mechanisms in hypertension}},
  journal = {Nature reviews. Cardiology},
  year    = {2024},
  doi     = {10.1038/s41569-023-00964-1},
  pmid    = {38172242},
  url     = {https://doi.org/10.1038/s41569-023-00964-1}
}

@article{gouveri2024-37950798,
  author  = {Gouveri, E. and Popovic, D. S. and Papanas, N.},
  title   = {{Potential New Therapeutic Implications of Semaglutide: New Colours of the Rainbow?}},
  journal = {Diabetes therapy : research, treatment and education of diabetes and related disorders},
  year    = {2024},
  doi     = {10.1007/s13300-023-01506-1},
  pmid    = {37950798},
  url     = {https://doi.org/10.1007/s13300-023-01506-1}
}

@article{chen2023-37042072,
  author  = {Chen, X. Q. and Sawa, M. and Becker, A. and Karachentsev, D. and Zuo, X. and Rynearson, K. D. and Tanzi, R. E. and Mobley, W. C.},
  title   = {{Retromer Proteins Reduced in Down Syndrome and the Dp16 Model: Impact of APP Dose and Preclinical Studies of a γ-Secretase Modulator}},
  journal = {Annals of neurology},
  year    = {2023},
  doi     = {10.1002/ana.26659},
  pmid    = {37042072},
  url     = {https://doi.org/10.1002/ana.26659}
}

@article{chun2022-35184428,
  author  = {Chun, M. Y. and Lee, J. and Jeong, J. H. and Roh, J. H. and Oh, S. J. and Oh, M. and Oh, J. S. and others},
  title   = {{18F-THK5351 PET Positivity and Longitudinal Changes in Cognitive Function in β-Amyloid-Negative Amnestic Mild Cognitive Impairment}},
  journal = {Yonsei medical journal},
  year    = {2022},
  doi     = {10.3349/ymj.2022.63.3.259},
  pmid    = {35184428},
  url     = {https://doi.org/10.3349/ymj.2022.63.3.259}
}

@article{desale2021-35006431,
  author  = {Desale, S. E. and Chidambaram, H. and Chinnathambi, S.},
  title   = {{G-protein coupled receptor, PI3K and Rho signaling pathways regulate the cascades of Tau and amyloid-β in Alzheimer's disease}},
  journal = {Molecular biomedicine},
  year    = {2021},
  doi     = {10.1186/s43556-021-00036-1},
  pmid    = {35006431},
  url     = {https://doi.org/10.1186/s43556-021-00036-1}
}

@article{zhao2021-33953790,
  author  = {Zhao, Z. J. and Wei, D. P. and Zheng, R. Z. and Peng, T. and Xiao, X. and Li, F. S.},
  title   = {{The Gene Coexpression Analysis Identifies Functional Modules Dynamically Changed After Traumatic Brain Injury}},
  journal = {Computational and mathematical methods in medicine},
  year    = {2021},
  doi     = {10.1155/2021/5511598},
  pmid    = {33953790},
  url     = {https://doi.org/10.1155/2021/5511598}
}

@article{filippone2021-33547827,
  author  = {Filippone, A. and Praticò, D.},
  title   = {{Endosome Dysregulation in Down Syndrome: A Potential Contributor to Alzheimer Disease Pathology}},
  journal = {Annals of neurology},
  year    = {2021},
  doi     = {10.1002/ana.26042},
  pmid    = {33547827},
  url     = {https://doi.org/10.1002/ana.26042}
}

@article{mota2020-33246465,
  author  = {Mota, M. and Porrini, V. and Parrella, E. and Benarese, M. and Bellucci, A. and Rhein, S. and Schwaninger, M. and Pizzi, M.},
  title   = {{Neuroprotective epi-drugs quench the inflammatory response and microglial/macrophage activation in a mouse model of permanent brain ischemia}},
  journal = {Journal of neuroinflammation},
  year    = {2020},
  doi     = {10.1186/s12974-020-02028-4},
  pmid    = {33246465},
  url     = {https://doi.org/10.1186/s12974-020-02028-4}
}

@article{kametani2020-33250706,
  author  = {Kametani, F. and Yoshida, M. and Matsubara, T. and Murayama, S. and Saito, Y. and Kawakami, I. and Onaya, M. and Tanaka, H. and others},
  title   = {{Comparison of Common and Disease-Specific Post-translational Modifications of Pathological Tau Associated With a Wide Range of Tauopathies}},
  journal = {Frontiers in neuroscience},
  year    = {2020},
  doi     = {10.3389/fnins.2020.581936},
  pmid    = {33250706},
  url     = {https://doi.org/10.3389/fnins.2020.581936}
}

@article{jiang2020-33177989,
  author  = {Jiang, S. and Bhaskar, K.},
  title   = {{Degradation and Transmission of Tau by Autophagic-Endolysosomal Networks and Potential Therapeutic Targets for Tauopathy}},
  journal = {Frontiers in molecular neuroscience},
  year    = {2020},
  doi     = {10.3389/fnmol.2020.586731},
  pmid    = {33177989},
  url     = {https://doi.org/10.3389/fnmol.2020.586731}
}

@article{huang2020-33028409,
  author  = {Huang, M. and Modeste, E. and Dammer, E. and Merino, P. and Taylor, G. and Duong, D. M. and Deng, Q. and Holler, C. J. and others},
  title   = {{Network analysis of the progranulin-deficient mouse brain proteome reveals pathogenic mechanisms shared in human frontotemporal dementia caused by GRN mutations}},
  journal = {Acta neuropathologica communications},
  year    = {2020},
  doi     = {10.1186/s40478-020-01037-x},
  pmid    = {33028409},
  url     = {https://doi.org/10.1186/s40478-020-01037-x}
}

@article{michalicova2020-33100967,
  author  = {Michalicova, A. and Majerova, P. and Kovac, A.},
  title   = {{Tau Protein and Its Role in Blood-Brain Barrier Dysfunction}},
  journal = {Frontiers in molecular neuroscience},
  year    = {2020},
  doi     = {10.3389/fnmol.2020.570045},
  pmid    = {33100967},
  url     = {https://doi.org/10.3389/fnmol.2020.570045}
}

@article{zhao2020-32964663,
  author  = {Zhao, Y. and Zeng, C. Y. and Li, X. H. and Yang, T. T. and Kuang, X. and Du, JR.},
  title   = {{Klotho overexpression improves amyloid-β clearance and cognition in the APP/PS1 mouse model of Alzheimer's disease}},
  journal = {Aging cell},
  year    = {2020},
  doi     = {10.1111/acel.13239},
  pmid    = {32964663},
  url     = {https://doi.org/10.1111/acel.13239}
}

@article{yang2020-32963694,
  author  = {Yang, W. and Liu, Y. and Xu, Q. Q. and Xian, Y. F. and Lin, Z. X.},
  title   = {{Sulforaphene Ameliorates Neuroinflammation and Hyperphosphorylated Tau Protein via Regulating the PI3K/Akt/GSK-3β Pathway in Experimental Models of Alzheimer's Disease}},
  journal = {Oxidative medicine and cellular longevity},
  year    = {2020},
  doi     = {10.1155/2020/4754195},
  pmid    = {32963694},
  url     = {https://doi.org/10.1155/2020/4754195}
}

@article{ruan2020-32811520,
  author  = {Ruan, Z. and Delpech, J. C. and Venkatesan Kalavai, S. and Van Enoo, A. A. and Hu, J. and Ikezu, S. and Ikezu, T.},
  title   = {{P2RX7 inhibitor suppresses exosome secretion and disease phenotype in P301S tau transgenic mice}},
  journal = {Molecular neurodegeneration},
  year    = {2020},
  doi     = {10.1186/s13024-020-00396-2},
  pmid    = {32811520},
  url     = {https://doi.org/10.1186/s13024-020-00396-2}
}

@article{afridi2020-32903682,
  author  = {Afridi, R. and Lee, W. H. and Suk, K.},
  title   = {{Microglia Gone Awry: Linking Immunometabolism to Neurodegeneration}},
  journal = {Frontiers in cellular neuroscience},
  year    = {2020},
  doi     = {10.3389/fncel.2020.00246},
  pmid    = {32903682},
  url     = {https://doi.org/10.3389/fncel.2020.00246}
}

@article{alosco2020-32778942,
  author  = {Alosco, M. L. and Cherry, J. D. and Huber, B. R. and Tripodis, Y. and Baucom, Z. and Kowall, N. W. and Saltiel, N. and Goldstein, L. E. and others},
  title   = {{Characterizing tau deposition in chronic traumatic encephalopathy (CTE): utility of the McKee CTE staging scheme}},
  journal = {Acta neuropathologica},
  year    = {2020},
  doi     = {10.1007/s00401-020-02197-9},
  pmid    = {32778942},
  url     = {https://doi.org/10.1007/s00401-020-02197-9}
}

@article{dealmeida2020-32692110,
  author  = {de Almeida, S. M. and Ribeiro, C. E. and Tang, B. and de Pereira, A. P. and Rotta, I. and Vaida, F. and Letendre, S. and Potter, M. and others},
  title   = {{Neurocytoskeleton Proteins in Cerebrospinal Fluid of People With HIV-1 Subtypes B and C}},
  journal = {Journal of acquired immune deficiency syndromes (1999)},
  year    = {2020},
  doi     = {10.1097/qai.0000000000002389},
  pmid    = {32692110},
  url     = {https://doi.org/10.1097/qai.0000000000002389}
}

@article{hannan2020-32714148,
  author  = {Hannan, M. A. and Dash, R. and Sohag, A. A. M. and Haque, M. N. and Moon, I. S.},
  title   = {{Neuroprotection Against Oxidative Stress: Phytochemicals Targeting TrkB Signaling and the Nrf2-ARE Antioxidant System}},
  journal = {Frontiers in molecular neuroscience},
  year    = {2020},
  doi     = {10.3389/fnmol.2020.00116},
  pmid    = {32714148},
  url     = {https://doi.org/10.3389/fnmol.2020.00116}
}

@article{lee2020-32419307,
  author  = {Lee, M. Y. and Lee, J. and Hyeon, S. J. and Cho, H. and Hwang, Y. J. and Shin, J. Y. and McKee, A. C. and Kowall, N. W. and others},
  title   = {{Epigenome signatures landscaped by histone H3K9me3 are associated with the synaptic dysfunction in Alzheimer's disease}},
  journal = {Aging cell},
  year    = {2020},
  doi     = {10.1111/acel.13153},
  pmid    = {32419307},
  url     = {https://doi.org/10.1111/acel.13153}
}

@article{fang2019-32009956,
  author  = {Fang, K. and Li, H. R. and Chen, X. X. and Gao, X. R. and Huang, L. L. and Du, A. Q. and Jiang, C. and Li, H. and others},
  title   = {{Quercetin Alleviates LPS-Induced Depression-Like Behavior in Rats via Regulating BDNF-Related Imbalance of Copine 6 and TREM1/2 in the Hippocampus and PFC}},
  journal = {Frontiers in pharmacology},
  year    = {2019},
  doi     = {10.3389/fphar.2019.01544},
  pmid    = {32009956},
  url     = {https://doi.org/10.3389/fphar.2019.01544}
}

@article{parbo2020-31898549,
  author  = {Parbo, P. and Madsen, L. S. and Ismail, R. and Zetterberg, H. and Blennow, K. and Eskildsen, S. F. and Vorup-Jensen, T. and Brooks, D. J.},
  title   = {{Low plasma neurofilament light levels associated with raised cortical microglial activation suggest inflammation acts to protect prodromal Alzheimer's disease}},
  journal = {Alzheimer's research \& therapy},
  year    = {2020},
  doi     = {10.1186/s13195-019-0574-0},
  pmid    = {31898549},
  url     = {https://doi.org/10.1186/s13195-019-0574-0}
}

@article{gallardofernandez2019-31906130,
  author  = {Gallardo-Fernández, M. and Hornedo-Ortega, R. and Alonso-Bellido, I. M. and Rodríguez-Gómez, J. A. and Troncoso, A. M. and García-Parrilla, M. C. and Venero, J. L. and Espinosa-Oliva, A. M. and others},
  title   = {{Hydroxytyrosol Decreases LPS- and α-Synuclein-Induced Microglial Activation In Vitro}},
  journal = {Antioxidants (Basel, Switzerland)},
  year    = {2019},
  doi     = {10.3390/antiox9010036},
  pmid    = {31906130},
  url     = {https://doi.org/10.3390/antiox9010036}
}

@article{jia2019-31801553,
  author  = {Jia, L. and Piña-Crespo, J. and Li, Y.},
  title   = {{Restoring Wnt/β-catenin signaling is a promising therapeutic strategy for Alzheimer's disease}},
  journal = {Molecular brain},
  year    = {2019},
  doi     = {10.1186/s13041-019-0525-5},
  pmid    = {31801553},
  url     = {https://doi.org/10.1186/s13041-019-0525-5}
}

@article{garciarevilla2019-31627485,
  author  = {García-Revilla, J. and Alonso-Bellido, I. M. and Burguillos, M. A. and Herrera, A. J. and Espinosa-Oliva, A. M. and Ruiz, R. and Cruz-Hernández, L. and García-Domínguez, I. and others},
  title   = {{Reformulating Pro-Oxidant Microglia in Neurodegeneration}},
  journal = {Journal of clinical medicine},
  year    = {2019},
  doi     = {10.3390/jcm8101719},
  pmid    = {31627485},
  url     = {https://doi.org/10.3390/jcm8101719}
}

@article{igbokwe2019-32206026,
  author  = {Igbokwe, I. O. and Igwenagu, E. and Igbokwe, N. A.},
  title   = {{Aluminium toxicosis: a review of toxic actions and effects}},
  journal = {Interdisciplinary toxicology},
  year    = {2019},
  doi     = {10.2478/intox-2019-0007},
  pmid    = {32206026},
  url     = {https://doi.org/10.2478/intox-2019-0007}
}

@article{visanji2019-31508228,
  author  = {Visanji, N. P. and Lang, A. E. and Kovacs, G. G.},
  title   = {{Beyond the synucleinopathies: alpha synuclein as a driving force in neurodegenerative comorbidities}},
  journal = {Translational neurodegeneration},
  year    = {2019},
  doi     = {10.1186/s40035-019-0172-x},
  pmid    = {31508228},
  url     = {https://doi.org/10.1186/s40035-019-0172-x}
}

@article{hallett2019-31331333,
  author  = {Hallett, P. J. and Engelender, S. and Isacson, O.},
  title   = {{Lipid and immune abnormalities causing age-dependent neurodegeneration and Parkinson's disease}},
  journal = {Journal of neuroinflammation},
  year    = {2019},
  doi     = {10.1186/s12974-019-1532-2},
  pmid    = {31331333},
  url     = {https://doi.org/10.1186/s12974-019-1532-2}
}

@article{xu2019-31283973,
  author  = {Xu, Q. and Xu, W. and Cheng, H. and Yuan, H. and Tan, X.},
  title   = {{Efficacy and mechanism of cGAMP to suppress Alzheimer's disease by elevating TREM2}},
  journal = {Brain, behavior, and immunity},
  year    = {2019},
  doi     = {10.1016/j.bbi.2019.07.004},
  pmid    = {31283973},
  url     = {https://doi.org/10.1016/j.bbi.2019.07.004}
}

@article{paula2019-31226738,
  author  = {Paula, P. C. and Angelica Maria, S. G. and Luis, C. H. and Gloria Patricia, C. G.},
  title   = {{Preventive Effect of Quercetin in a Triple Transgenic Alzheimer's Disease Mice Model}},
  journal = {Molecules (Basel, Switzerland)},
  year    = {2019},
  doi     = {10.3390/molecules24122287},
  pmid    = {31226738},
  url     = {https://doi.org/10.3390/molecules24122287}
}

@article{evans2019-31268600,
  author  = {Evans, H. T. and Benetatos, J. and van Roijen, M. and Bodea, L. G. and Götz, J.},
  title   = {{Decreased synthesis of ribosomal proteins in tauopathy revealed by non-canonical amino acid labelling}},
  journal = {The EMBO journal},
  year    = {2019},
  doi     = {10.15252/embj.2018101174},
  pmid    = {31268600},
  url     = {https://doi.org/10.15252/embj.2018101174}
}

@article{choi2019-31086314,
  author  = {Choi, S. Y. and Lopez-Gonzalez, R. and Krishnan, G. and Phillips, H. L. and Li, A. N. and Seeley, W. W. and Yao, W. D. and Almeida, S. and others},
  title   = {{C9ORF72-ALS/FTD-associated poly(GR) binds Atp5a1 and compromises mitochondrial function in vivo}},
  journal = {Nature neuroscience},
  year    = {2019},
  doi     = {10.1038/s41593-019-0397-0},
  pmid    = {31086314},
  url     = {https://doi.org/10.1038/s41593-019-0397-0}
}

@article{beaver2019-31091472,
  author  = {Beaver, S. K. and Mesa-Torres, N. and Pey, A. L. and Timson, D. J.},
  title   = {{NQO1: A target for the treatment of cancer and neurological diseases, and a model to understand loss of function disease mechanisms}},
  journal = {Biochimica et biophysica acta. Proteins and proteomics},
  year    = {2019},
  doi     = {10.1016/j.bbapap.2019.05.002},
  pmid    = {31091472},
  url     = {https://doi.org/10.1016/j.bbapap.2019.05.002}
}

@article{inoue2019-31036637,
  author  = {Inoue, T. and Saito, S. and Tanaka, M. and Yamakage, H. and Kusakabe, T. and Shimatsu, A. and Ihara, M. and Satoh-Asahara, N.},
  title   = {{Pleiotropic neuroprotective effects of taxifolin in cerebral amyloid angiopathy}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2019},
  doi     = {10.1073/pnas.1901659116},
  pmid    = {31036637},
  url     = {https://doi.org/10.1073/pnas.1901659116}
}

@article{gomezsuaga2019-30841933,
  author  = {Gómez-Suaga, P. and Pérez-Nievas, B. G. and Glennon, E. B. and Lau, D. H. W. and Paillusson, S. and Mórotz, G. M. and Calì, T. and Pizzo, P. and others},
  title   = {{The VAPB-PTPIP51 endoplasmic reticulum-mitochondria tethering proteins are present in neuronal synapses and regulate synaptic activity}},
  journal = {Acta neuropathologica communications},
  year    = {2019},
  doi     = {10.1186/s40478-019-0688-4},
  pmid    = {30841933},
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  year    = {2011},
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  pmid    = {21427166},
  url     = {https://doi.org/10.1093/cercor/bhr033}
}

@article{butler2011-21309754,
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  title   = {{Vitamin D receptor gene as a candidate gene for Parkinson disease}},
  journal = {Annals of human genetics},
  year    = {2011},
  doi     = {10.1111/j.1469-1809.2010.00631.x},
  pmid    = {21309754},
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}

@article{bellucci2011-21212632,
  author  = {Bellucci, A. and Bugiani, O. and Ghetti, B. and Spillantini, M. G.},
  title   = {{Presence of reactive microglia and neuroinflammatory mediators in a case of frontotemporal dementia with P301S mutation}},
  journal = {Neuro-degenerative diseases},
  year    = {2011},
  doi     = {10.1159/000322228},
  pmid    = {21212632},
  url     = {https://doi.org/10.1159/000322228}
}

@article{linnartz2010-20721346,
  author  = {Linnartz, B. and Wang, Y. and Neumann, H.},
  title   = {{Microglial immunoreceptor tyrosine-based activation and inhibition motif signaling in neuroinflammation}},
  journal = {International journal of Alzheimer's disease},
  year    = {2010},
  doi     = {10.4061/2010/587463},
  pmid    = {20721346},
  url     = {https://doi.org/10.4061/2010/587463}
}

@article{fisher2010-20520819,
  author  = {Fisher, Y. and Nemirovsky, A. and Baron, R. and Monsonego, A.},
  title   = {{T cells specifically targeted to amyloid plaques enhance plaque clearance in a mouse model of Alzheimer's disease}},
  journal = {PloS one},
  year    = {2010},
  doi     = {10.1371/journal.pone.0010830},
  pmid    = {20520819},
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}

@article{kang2010-20484053,
  author  = {Kang, E. L. and Cameron, A. N. and Piazza, F. and Walker, K. R. and Tesco, G.},
  title   = {{Ubiquitin regulates GGA3-mediated degradation of BACE1}},
  journal = {The Journal of biological chemistry},
  year    = {2010},
  doi     = {10.1074/jbc.m109.092742},
  pmid    = {20484053},
  url     = {https://doi.org/10.1074/jbc.m109.092742}
}

@article{mcallister2010-20505099,
  author  = {McAllister, C. and Long, J. and Bowers, A. and Walker, A. and Cao, P. and Honda, S. and Harada, N. and Staufenbiel, M. and others},
  title   = {{Genetic targeting aromatase in male amyloid precursor protein transgenic mice down-regulates beta-secretase (BACE1) and prevents Alzheimer-like pathology and cognitive impairment}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2010},
  doi     = {10.1523/jneurosci.1180-10.2010},
  pmid    = {20505099},
  url     = {https://doi.org/10.1523/jneurosci.1180-10.2010}
}

@article{lanfranchi2010-20202074,
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  title   = {{Executive function in adolescents with Down Syndrome}},
  journal = {Journal of intellectual disability research : JIDR},
  year    = {2010},
  doi     = {10.1111/j.1365-2788.2010.01262.x},
  pmid    = {20202074},
  url     = {https://doi.org/10.1111/j.1365-2788.2010.01262.x}
}

@article{plaschke2010-20110613,
  author  = {Plaschke, K. and Kopitz, J. and Siegelin, M. and Schliebs, R. and Salkovic-Petrisic, M. and Riederer, P. and Hoyer, S.},
  title   = {{Insulin-resistant brain state after intracerebroventricular streptozotocin injection exacerbates Alzheimer-like changes in Tg2576 AbetaPP-overexpressing mice}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2010},
  doi     = {10.3233/jad-2010-1270},
  pmid    = {20110613},
  url     = {https://doi.org/10.3233/jad-2010-1270}
}

@article{granic2010-20032300,
  author  = {Granic, A. and Padmanabhan, J. and Norden, M. and Potter, H.},
  title   = {{Alzheimer Abeta peptide induces chromosome mis-segregation and aneuploidy, including trisomy 21: requirement for tau and APP}},
  journal = {Molecular biology of the cell},
  year    = {2010},
  doi     = {10.1091/mbc.e09-10-0850},
  pmid    = {20032300},
  url     = {https://doi.org/10.1091/mbc.e09-10-0850}
}

@article{middeldorp2009-19888461,
  author  = {Middeldorp, J. and van den Berge, S. A. and Aronica, E. and Speijer, D. and Hol, E. M.},
  title   = {{Specific human astrocyte subtype revealed by affinity purified GFAP antibody; unpurified serum cross-reacts with neurofilament-L in Alzheimer}},
  journal = {PloS one},
  year    = {2009},
  doi     = {10.1371/journal.pone.0007663},
  pmid    = {19888461},
  url     = {https://doi.org/10.1371/journal.pone.0007663}
}

@article{yadav2009-19768553,
  author  = {Yadav, A. and Collman, R. G.},
  title   = {{CNS inflammation and macrophage/microglial biology associated with HIV-1 infection}},
  journal = {Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology},
  year    = {2009},
  doi     = {10.1007/s11481-009-9174-2},
  pmid    = {19768553},
  url     = {https://doi.org/10.1007/s11481-009-9174-2}
}

@article{eggert2009-19596858,
  author  = {Eggert, S. and Midthune, B. and Cottrell, B. and Koo, E. H.},
  title   = {{Induced dimerization of the amyloid precursor protein leads to decreased amyloid-beta protein production}},
  journal = {The Journal of biological chemistry},
  year    = {2009},
  doi     = {10.1074/jbc.m109.038646},
  pmid    = {19596858},
  url     = {https://doi.org/10.1074/jbc.m109.038646}
}

@article{kraska2011-19564059,
  author  = {Kraska, A. and Dorieux, O. and Picq, J. L. and Petit, F. and Bourrin, E. and Chenu, E. and Volk, A. and Perret, M. and others},
  title   = {{Age-associated cerebral atrophy in mouse lemur primates}},
  journal = {Neurobiology of aging},
  year    = {2011},
  doi     = {10.1016/j.neurobiolaging.2009.05.018},
  pmid    = {19564059},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2009.05.018}
}

@article{kusters2009-19250275,
  author  = {Kusters, M. A. and Verstegen, R. H. and Gemen, E. F. and de Vries, E.},
  title   = {{Intrinsic defect of the immune system in children with Down syndrome: a review}},
  journal = {Clinical and experimental immunology},
  year    = {2009},
  doi     = {10.1111/j.1365-2249.2009.03890.x},
  pmid    = {19250275},
  url     = {https://doi.org/10.1111/j.1365-2249.2009.03890.x}
}

@article{braak2009-19230552,
  author  = {Braak, H. and Del Tredici, K.},
  title   = {{Neuroanatomy and pathology of sporadic Parkinson's disease}},
  journal = {Advances in anatomy, embryology, and cell biology},
  year    = {2009},
  doi     = {10.1007/978-3-540-79850-7},
  pmid    = {19230552},
  url     = {https://doi.org/10.1007/978-3-540-79850-7}
}

@article{ko2009-19011241,
  author  = {Ko, M. H. and Puglielli, L.},
  title   = {{Two endoplasmic reticulum (ER)/ER Golgi intermediate compartment-based lysine acetyltransferases post-translationally regulate BACE1 levels}},
  journal = {The Journal of biological chemistry},
  year    = {2009},
  doi     = {10.1074/jbc.m804901200},
  pmid    = {19011241},
  url     = {https://doi.org/10.1074/jbc.m804901200}
}

@article{cheeran2008-18845611,
  author  = {Cheeran, B. and Talelli, P. and Mori, F. and Koch, G. and Suppa, A. and Edwards, M. and Houlden, H. and Bhatia, K. and others},
  title   = {{A common polymorphism in the brain-derived neurotrophic factor gene (BDNF) modulates human cortical plasticity and the response to rTMS}},
  journal = {The Journal of physiology},
  year    = {2008},
  doi     = {10.1113/jphysiol.2008.159905},
  pmid    = {18845611},
  url     = {https://doi.org/10.1113/jphysiol.2008.159905}
}

@article{hopwood2009-18840552,
  author  = {Hopwood, B. and Tsykin, A. and Findlay, D. M. and Fazzalari, N. L.},
  title   = {{Gene expression profile of the bone microenvironment in human fragility fracture bone}},
  journal = {Bone},
  year    = {2009},
  doi     = {10.1016/j.bone.2008.08.120},
  pmid    = {18840552},
  url     = {https://doi.org/10.1016/j.bone.2008.08.120}
}

@article{jonas2008-18660751,
  author  = {Jonas, M. C. and Costantini, C. and Puglielli, L.},
  title   = {{PCSK9 is required for the disposal of non-acetylated intermediates of the nascent membrane protein BACE1}},
  journal = {EMBO reports},
  year    = {2008},
  doi     = {10.1038/embor.2008.132},
  pmid    = {18660751},
  url     = {https://doi.org/10.1038/embor.2008.132}
}

@article{marcade2008-18397369,
  author  = {Marcade, M. and Bourdin, J. and Loiseau, N. and Peillon, H. and Rayer, A. and Drouin, D. and Schweighoffer, F. and Désiré, L.},
  title   = {{Etazolate, a neuroprotective drug linking GABA(A) receptor pharmacology to amyloid precursor protein processing}},
  journal = {Journal of neurochemistry},
  year    = {2008},
  doi     = {10.1111/j.1471-4159.2008.05396.x},
  pmid    = {18397369},
  url     = {https://doi.org/10.1111/j.1471-4159.2008.05396.x}
}

@article{rosen2008-18481275,
  author  = {Rosen, R. F. and Farberg, A. S. and Gearing, M. and Dooyema, J. and Long, P. M. and Anderson, D. C. and Davis-Turak, J. and Coppola, G. and others},
  title   = {{Tauopathy with paired helical filaments in an aged chimpanzee}},
  journal = {The Journal of comparative neurology},
  year    = {2008},
  doi     = {10.1002/cne.21744},
  pmid    = {18481275},
  url     = {https://doi.org/10.1002/cne.21744}
}

@article{price2008-18447615,
  author  = {Price, R. W. and Spudich, S.},
  title   = {{Antiretroviral therapy and central nervous system HIV type 1 infection}},
  journal = {The Journal of infectious diseases},
  year    = {2008},
  doi     = {10.1086/533419},
  pmid    = {18447615},
  url     = {https://doi.org/10.1086/533419}
}

@article{charles2008-18391000,
  author  = {Charles, J. F. and Humphrey, M. B. and Zhao, X. and Quarles, E. and Nakamura, M. C. and Aderem, A. and Seaman, W. E. and Smith, K. D.},
  title   = {{The innate immune response to Salmonella enterica serovar Typhimurium by macrophages is dependent on TREM2-DAP12}},
  journal = {Infection and immunity},
  year    = {2008},
  doi     = {10.1128/iai.00115-08},
  pmid    = {18391000},
  url     = {https://doi.org/10.1128/iai.00115-08}
}

@article{mckeon2007-17923638,
  author  = {McKeon, A. and Marnane, M. and O'connell, M. and Stack, J. P. and Kelly, P. J. and Lynch, T.},
  title   = {{Potassium channel antibody associated encephalopathy presenting with a frontotemporal dementia like syndrome}},
  journal = {Archives of neurology},
  year    = {2007},
  doi     = {10.1001/archneur.64.10.1528},
  pmid    = {17923638},
  url     = {https://doi.org/10.1001/archneur.64.10.1528}
}

@article{bandyopadhyay2007-17428800,
  author  = {Bandyopadhyay, B. and Li, G. and Yin, H. and Kuret, J.},
  title   = {{Tau aggregation and toxicity in a cell culture model of tauopathy}},
  journal = {The Journal of biological chemistry},
  year    = {2007},
  doi     = {10.1074/jbc.m700192200},
  pmid    = {17428800},
  url     = {https://doi.org/10.1074/jbc.m700192200}
}

@article{dekosky2007-17420316,
  author  = {DeKosky, S. T. and Abrahamson, E. E. and Ciallella, JR. and Paljug, W. R. and Wisniewski, SR. and Clark, R. S. and Ikonomovic, M. D.},
  title   = {{Association of increased cortical soluble abeta42 levels with diffuse plaques after severe brain injury in humans}},
  journal = {Archives of neurology},
  year    = {2007},
  doi     = {10.1001/archneur.64.4.541},
  pmid    = {17420316},
  url     = {https://doi.org/10.1001/archneur.64.4.541}
}

@article{pieczenik2007-17239370,
  author  = {Pieczenik, SR. and Neustadt, J.},
  title   = {{Mitochondrial dysfunction and molecular pathways of disease}},
  journal = {Experimental and molecular pathology},
  year    = {2007},
  doi     = {10.1016/j.yexmp.2006.09.008},
  pmid    = {17239370},
  url     = {https://doi.org/10.1016/j.yexmp.2006.09.008}
}

@article{pierrot2006-17085446,
  author  = {Pierrot, N. and Santos, S. F. and Feyt, C. and Morel, M. and Brion, J. P. and Octave, J. N.},
  title   = {{Calcium-mediated transient phosphorylation of tau and amyloid precursor protein followed by intraneuronal amyloid-beta accumulation}},
  journal = {The Journal of biological chemistry},
  year    = {2006},
  doi     = {10.1074/jbc.m606015200},
  pmid    = {17085446},
  url     = {https://doi.org/10.1074/jbc.m606015200}
}

@article{wang2006-16645044,
  author  = {Wang, R. and Zhang, Y. W. and Zhang, X. and Liu, R. and Hong, S. and Xia, K. and Xia, J. and others},
  title   = {{Transcriptional regulation of APH-1A and increased gamma-secretase cleavage of APP and Notch by HIF-1 and hypoxia}},
  journal = {FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year    = {2006},
  doi     = {10.1096/fj.06-5839fje},
  pmid    = {16645044},
  url     = {https://doi.org/10.1096/fj.06-5839fje}
}

@article{kojro2006-16401644,
  author  = {Kojro, E. and Postina, R. and Buro, C. and Meiringer, C. and Gehrig-Burger, K. and Fahrenholz, F.},
  title   = {{The neuropeptide PACAP promotes the alpha-secretase pathway for processing the Alzheimer amyloid precursor protein}},
  journal = {FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year    = {2006},
  doi     = {10.1096/fj.05-4812fje},
  pmid    = {16401644},
  url     = {https://doi.org/10.1096/fj.05-4812fje}
}

@article{desire2005-16150730,
  author  = {Désiré, L. and Bourdin, J. and Loiseau, N. and Peillon, H. and Picard, V. and De Oliveira, C. and Bachelot, F. and Leblond, B. and others},
  title   = {{RAC1 inhibition targets amyloid precursor protein processing by gamma-secretase and decreases Abeta production in vitro and in vivo}},
  journal = {The Journal of biological chemistry},
  year    = {2005},
  doi     = {10.1074/jbc.m507913200},
  pmid    = {16150730},
  url     = {https://doi.org/10.1074/jbc.m507913200}
}

@article{fotinopoulou2005-16027166,
  author  = {Fotinopoulou, A. and Tsachaki, M. and Vlavaki, M. and Poulopoulos, A. and Rostagno, A. and Frangione, B. and Ghiso, J. and Efthimiopoulos, S.},
  title   = {{BRI2 interacts with amyloid precursor protein (APP) and regulates amyloid beta (Abeta) production}},
  journal = {The Journal of biological chemistry},
  year    = {2005},
  doi     = {10.1074/jbc.c500231200},
  pmid    = {16027166},
  url     = {https://doi.org/10.1074/jbc.c500231200}
}

@article{tamboli2005-15923191,
  author  = {Tamboli, I. Y. and Prager, K. and Barth, E. and Heneka, M. and Sandhoff, K. and Walter, J.},
  title   = {{Inhibition of glycosphingolipid biosynthesis reduces secretion of the beta-amyloid precursor protein and amyloid beta-peptide}},
  journal = {The Journal of biological chemistry},
  year    = {2005},
  doi     = {10.1074/jbc.m414525200},
  pmid    = {15923191},
  url     = {https://doi.org/10.1074/jbc.m414525200}
}

@article{yancopoulou2005-15804056,
  author  = {Yancopoulou, D. and Xuereb, J. H. and Crowther, R. A. and Hodges, JR. and Spillantini, M. G.},
  title   = {{Tau and alpha-synuclein inclusions in a case of familial frontotemporal dementia and progressive aphasia}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2005},
  doi     = {10.1093/jnen/64.3.245},
  pmid    = {15804056},
  url     = {https://doi.org/10.1093/jnen/64.3.245}
}

@article{kiialainen2005-15686960,
  author  = {Kiialainen, A. and Hovanes, K. and Paloneva, J. and Kopra, O. and Peltonen, L.},
  title   = {{Dap12 and Trem2, molecules involved in innate immunity and neurodegeneration, are co-expressed in the CNS}},
  journal = {Neurobiology of disease},
  year    = {2005},
  doi     = {10.1016/j.nbd.2004.09.007},
  pmid    = {15686960},
  url     = {https://doi.org/10.1016/j.nbd.2004.09.007}
}

@article{youdim2005-15573406,
  author  = {Youdim, M. B. and Bar Am, O. and Yogev-Falach, M. and Weinreb, O. and Maruyama, W. and Naoi, M. and Amit, T.},
  title   = {{Rasagiline: neurodegeneration, neuroprotection, and mitochondrial permeability transition}},
  journal = {Journal of neuroscience research},
  year    = {2005},
  doi     = {10.1002/jnr.20350},
  pmid    = {15573406},
  url     = {https://doi.org/10.1002/jnr.20350}
}

@article{trommer2004-15570172,
  author  = {Trommer, B. L. and Shah, C. and Yun, S. H. and Gamkrelidze, G. and Pasternak, E. S. and Ye, G. L. and Sotak, M. and Sullivan, P. M. and others},
  title   = {{ApoE isoform affects LTP in human targeted replacement mice}},
  journal = {Neuroreport},
  year    = {2004},
  doi     = {10.1097/00001756-200412030-00020},
  pmid    = {15570172},
  url     = {https://doi.org/10.1097/00001756-200412030-00020}
}

@article{avison2004-15579291,
  author  = {Avison, M. J. and Nath, A. and Greene-Avison, R. and Schmitt, F. A. and Greenberg, R. N. and Berger, JR.},
  title   = {{Neuroimaging correlates of HIV-associated BBB compromise}},
  journal = {Journal of neuroimmunology},
  year    = {2004},
  doi     = {10.1016/j.jneuroim.2004.08.025},
  pmid    = {15579291},
  url     = {https://doi.org/10.1016/j.jneuroim.2004.08.025}
}

@article{saito2004-15099022,
  author  = {Saito, Y. and Suzuki, K. and Hulette, C. M. and Murayama, S.},
  title   = {{Aberrant phosphorylation of alpha-synuclein in human Niemann-Pick type C1 disease}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2004},
  doi     = {10.1093/jnen/63.4.323},
  pmid    = {15099022},
  url     = {https://doi.org/10.1093/jnen/63.4.323}
}

@article{zitnanova2004-14967170,
  author  = {Zitnanová, I. and Korytár, P. and Aruoma, O. I. and Sustrová, M. and Garaiová, I. and Muchová, J. and Kalnovicová, T. and others},
  title   = {{Uric acid and allantoin levels in Down syndrome: antioxidant and oxidative stress mechanisms?}},
  journal = {Clinica chimica acta; international journal of clinical chemistry},
  year    = {2004},
  doi     = {10.1016/j.cccn.2003.11.020},
  pmid    = {14967170},
  url     = {https://doi.org/10.1016/j.cccn.2003.11.020}
}

@article{mizuno2004-14975696,
  author  = {Mizuno, T. and Kurotani, T. and Komatsu, Y. and Kawanokuchi, J. and Kato, H. and Mitsuma, N. and Suzumura, A.},
  title   = {{Neuroprotective role of phosphodiesterase inhibitor ibudilast on neuronal cell death induced by activated microglia}},
  journal = {Neuropharmacology},
  year    = {2004},
  doi     = {10.1016/j.neuropharm.2003.09.009},
  pmid    = {14975696},
  url     = {https://doi.org/10.1016/j.neuropharm.2003.09.009}
}

@article{bianchin2004-15049507,
  author  = {Bianchin, M. M. and Capella, H. M. and Chaves, D. L. and Steindel, M. and Grisard, E. C. and Ganev, G. G. and da Silva Júnior, J. P. and Neto Evaldo, S. and others},
  title   = {{Nasu-Hakola disease (polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy--PLOSL): a dementia associated with bone cystic lesions. From clinical to genetic and molecular aspects}},
  journal = {Cellular and molecular neurobiology},
  year    = {2004},
  doi     = {10.1023/b:cemn.0000012721.08168.ee},
  pmid    = {15049507},
  url     = {https://doi.org/10.1023/b:cemn.0000012721.08168.ee}
}

@article{deane2003-12808450,
  author  = {Deane, R. and Du Yan, S. and Submamaryan, R. K. and LaRue, B. and Jovanovic, S. and Hogg, E. and Welch, D. and Manness, L. and others},
  title   = {{RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain}},
  journal = {Nature medicine},
  year    = {2003},
  doi     = {10.1038/nm890},
  pmid    = {12808450},
  url     = {https://doi.org/10.1038/nm890}
}

@article{hawkes2003-12671941,
  author  = {Hawkes, C.},
  title   = {{Olfaction in neurodegenerative disorder}},
  journal = {Movement disorders : official journal of the Movement Disorder Society},
  year    = {2003},
  doi     = {10.1002/mds.10379},
  pmid    = {12671941},
  url     = {https://doi.org/10.1002/mds.10379}
}

@article{iwata2002-12484568,
  author  = {Iwata, A. and Chen, X. H. and McIntosh, T. K. and Browne, K. D. and Smith, D. H.},
  title   = {{Long-term accumulation of amyloid-beta in axons following brain trauma without persistent upregulation of amyloid precursor protein genes}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2002},
  doi     = {10.1093/jnen/61.12.1056},
  pmid    = {12484568},
  url     = {https://doi.org/10.1093/jnen/61.12.1056}
}

@article{banisadr2002-12431218,
  author  = {Banisadr, G. and Fontanges, P. and Haour, F. and Kitabgi, P. and Rostène, W. and Mélik Parsadaniantz, S.},
  title   = {{Neuroanatomical distribution of CXCR4 in adult rat brain and its localization in cholinergic and dopaminergic neurons}},
  journal = {The European journal of neuroscience},
  year    = {2002},
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  title   = {{Electrical stimulation of the vagus nerve improves amyloid pathology in delirium superimposed on dementia}},
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  title   = {{The White Matter Hyperintensity Shape and Brain Clearance (WHIMAS) Study for Identification of Novel 7T Magnetic Resonance Imaging Markers of Cerebral Small Vessel Disease: Protocol for a Cross-Sectional Study}},
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@article{nelson2025-41433607,
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  title   = {{Adaptation of a Protocol for Disclosure of Amyloid PET Results for Adults with Down Syndrome and Their Caregivers}},
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@article{millar2025-41434143,
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  title   = {{Differing network patterns of functional connectivity and amyloid PET between tau PET subtypes}},
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@article{millar2025-41442473,
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  title   = {{Differing network patterns of functional connectivity and amyloid PET between tau PET subtypes}},
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@article{flores2025-41433453,
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  title   = {{Comparing Off‐Target Meningeal and Skull Signal in Head‐to‐Head MK‐6240 and AV‐1451 Tau PET}},
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  title   = {{Monoamine Oxidase‐B (MAO‐B) Identifies Neurotoxic Reactive Astrocytes in Alzheimer's Disease and Related Dementias}},
  journal = {Alzheimer s \& Dementia},
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@article{reyes2025-41434809,
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  title   = {{Harmonization Remains Unresolved: The Case of White Matter Hyperintensity Using ComBat And Deming Regression}},
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@article{massey2025-41213966,
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  title   = {{Refining the diagnostic accuracy of Parkinsonian disorders using metaphenomic annotation of the clinicopathological literature}},
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@article{yan2025-41101651,
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  title   = {{Characterizing the distinct neuroanatomical phenotypes, cognitive profiles, and transcriptomic signatures of brain structural subtypes in Parkinson's disease with mild cognitive impairment}},
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@article{chu2025-41061808,
  author  = {Chu, Min and Yue, Ailing and Nan, Haitian and Ye, Hong and Qu, Miao and Wu, Liyong},
  title   = {{Glymphatic activity is linked to the synaptic vesicle cycle pathway in frontotemporal dementia: A metabolomics study}},
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  year    = {2025},
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@article{zoatier2025-41047159,
  author  = {Zoatier, Bayan and Yildiztekin, Gizem and Alagöz, Mehmet Abdullah and Hepokur, Ceylan and Dilek, Esra and Algül, Öztekin},
  title   = {{Benzoxazole Derivatives as Dual p38α Mitogen‐Activated Protein Kinase and Acetylcholinesterase Inhibitors: Design, Synthesis, and Evaluation for Alzheimer's Disease and Cancer Therapy}},
  journal = {ChemMedChem},
  year    = {2025},
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@article{ginerperez2025-41035890,
  author  = {Giner-Pérez, Lola and Gallego, Juan and Giménez‐Garzó, Carla and Batallas, Daniela and Jarquín‐Díaz, Víctor Hugo and Casanova‐Ferrer, Franc and Fiorillo, Alessandra and Urios, Amparo and others},
  title   = {{The analysis of the gut microbiome during liver disease progression led to the identification of biomarkers for related mild cognitive impairment}},
  journal = {Frontiers in Microbiology},
  year    = {2025},
  doi     = {10.3389/fmicb.2025.1670512},
  pmid    = {41035890},
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@article{haddad2025-40970479,
  author  = {Haddad, Celine and Daneault, Véronique and Ayral, Violette and Filiatrault, Marie and Pastor‐Bernier, Alexandre and Tremblay, Christina and Boré, Arnaud and Descoteaux, Maxime and others},
  title   = {{Free water predicts dementia with Lewy bodies in isolated REM sleep behavior disorder}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
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  pmid    = {40970479},
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}

@article{zheng2025-40919134,
  author  = {Zheng, Kai and Huang, He‐Zhou and Liu, Dan and Brazhe, Nadezda A. and Chen, Jiajie and Zhu, Ling‐Qiang},
  title   = {{Targeting the miR‐96‐5p/Cathepsin B Pathway to Alleviate Neuron‐Derived Neuroinflammation in Alzheimer's Disease}},
  journal = {MedComm},
  year    = {2025},
  doi     = {10.1002/mco2.70368},
  pmid    = {40919134},
  url     = {https://doi.org/10.1002/mco2.70368}
}

@article{weiss2025-40816764,
  author  = {Weiss, Blaine E. and Gant, John C. and Lin, Ruei‐Lung and Gollihue, Jenna L. and Rogers, Colin B. and Kraner, Susan D. and Rucker, Edmund B. and Katsumata, Yuriko and others},
  title   = {{Disrupted Calcium Dynamics in Reactive Astrocytes Occur with End Feet–Arteriole Decoupling in an Amyloid Mouse Model of Alzheimer's Disease}},
  journal = {Journal of Neuroscience},
  year    = {2025},
  doi     = {10.1523/jneurosci.0349-25.2025},
  pmid    = {40816764},
  url     = {https://doi.org/10.1523/jneurosci.0349-25.2025}
}

@article{du2025-40783546,
  author  = {Du, Muzi and Akerman, Suleyman C. and Fare, Charlotte M. and Ruan, Linhao and Vidensky, Svetlana and Mamedova, Lyudmila and Koo, Katie K. and Lee, Joshua Y. and others},
  title   = {{Divergent and convergent TMEM106B pathology in murine models of neurodegeneration and human disease}},
  journal = {Acta Neuropathologica Communications},
  year    = {2025},
  doi     = {10.1186/s40478-025-02087-9},
  pmid    = {40783546},
  url     = {https://doi.org/10.1186/s40478-025-02087-9}
}

@article{demunter2025-40801602,
  author  = {de Munter, Johannes and Chaprov, Kirill and Lang, Ekkehard and Sitdikova, Kseniia and Wolters, Erik Ch. and Svirin, Evgeniy P. and Kassenova, Aliya and Tsoy, Andrey and others},
  title   = {{Neuro-Cells Mitigate Amyloid Plaque Formation and Behavioral Deficits in the APPswe/PS1dE9 Model of Alzheimer Disease While Also Reducing IL-6 Production in Human Monocytes}},
  journal = {Cells},
  year    = {2025},
  doi     = {10.3390/cells14151168},
  pmid    = {40801602},
  url     = {https://doi.org/10.3390/cells14151168}
}

@article{oshaghi2025-40741424,
  author  = {Oshaghi, Ebrahim Abbasi and Khodadadi, Iraj},
  title   = {{High-fat diet may increase the risk of insulin resistance by inducing dysbiosis}},
  journal = {Metabolism Open},
  year    = {2025},
  doi     = {10.1016/j.metop.2025.100381},
  pmid    = {40741424},
  url     = {https://doi.org/10.1016/j.metop.2025.100381}
}

@article{boyle2025-40633679,
  author  = {Boyle, Nicholas R. and Fox, Stephanie N. and Tadepalli, Aniketh S. and Seyfried, Nicholas T. and Kukar, Thomas L. and Ramos, Eliana Marisa and Nana, Alissa L. and Spina, Salvatore and others},
  title   = {{Reduction of sphingomyelinase activity associated with progranulin deficiency and frontotemporal dementia}},
  journal = {Neurobiology of Disease},
  year    = {2025},
  doi     = {10.1016/j.nbd.2025.107024},
  pmid    = {40633679},
  url     = {https://doi.org/10.1016/j.nbd.2025.107024}
}

@article{youssef2025-40722308,
  author  = {Youssef, Hossam and Weissmann, Carina and Uruk, Gӧkhan and Gatto, Rodolfo G.},
  title   = {{Looking into Abnormal Co-Expressions of Tau and TDP-43 in the Realm of Mixed Dementia Types: A Double-Punch Scenario}},
  journal = {Brain Sciences},
  year    = {2025},
  doi     = {10.3390/brainsci15070716},
  pmid    = {40722308},
  url     = {https://doi.org/10.3390/brainsci15070716}
}

@article{hung2025-40570368,
  author  = {Hung, Christy and Llorian, Miriam and Pal, Koustav and Livesey, Frederick J. and Choudhary, Jyoti Sharma and Roumeliotis, Theodoros I. and Patani, Rickie},
  title   = {{Mislocalization of nucleic acids is a convergent and targetable mechanism in Alzheimer's disease and frontotemporal dementia}},
  journal = {Cell Reports},
  year    = {2025},
  doi     = {10.1016/j.celrep.2025.115867},
  pmid    = {40570368},
  url     = {https://doi.org/10.1016/j.celrep.2025.115867}
}

@article{choo2025-40561557,
  author  = {Choo, Cameron Mavericks and Tan, Chin Hong},
  title   = {{Effects of regional white matter hyperintensities and β-amyloid on domain-specific cognition and progression to dementia}},
  journal = {Brain and Cognition},
  year    = {2025},
  doi     = {10.1016/j.bandc.2025.106332},
  pmid    = {40561557},
  url     = {https://doi.org/10.1016/j.bandc.2025.106332}
}

@article{rosas2025-40474237,
  author  = {Rosas, H. D. and Lai, F. and Mercaldo, N.},
  title   = {{Lipoprotein(a) levels in Down syndrome: A conundrum}},
  journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
  year    = {2025},
  doi     = {10.1002/alz.70338},
  pmid    = {40474237},
  url     = {https://doi.org/10.1002/alz.70338}
}

@article{onu2025-40430185,
  author  = {Onu, Ana and Trofin, Daniela Marilena and Tutu, Andrei and Onu, Ilie and Galaction, Anca‐Irina and Sardaru, Dragos-Petrica and Trofin, Dan and Onita, Cristiana Amalia and others},
  title   = {{Integrative Strategies for Preventing and Managing Metabolic Syndrome: The Impact of Exercise and Diet on Oxidative Stress Reduction—A Review}},
  journal = {Life},
  year    = {2025},
  doi     = {10.3390/life15050757},
  pmid    = {40430185},
  url     = {https://doi.org/10.3390/life15050757}
}

@article{chaigneau2025-40304030,
  author  = {Chaigneau, Thomas and Sha, Sha and Roux, Candice M. and Aïd, Saba and Faucher, Alice and Chantran, Yannick and Dorothée, Guillaume and Krantic, Slavica},
  title   = {{Subtle Alterations in Hippocampal Neuronal Activity Coincide With Early Sex‐Specific Differences in Amyloidosis and Microglia in a Pre‐Symptomatic Mouse Model of Alzheimer‐Like Pathology}},
  journal = {Glia},
  year    = {2025},
  doi     = {10.1002/glia.70029},
  pmid    = {40304030},
  url     = {https://doi.org/10.1002/glia.70029}
}

@article{heller2025-41051875,
  author  = {Heller, Nathan H. and Barrett, Frederick Streeter and Buchborn, Tobias and Collerton, Daniel and Dupuis, David and Halberstadt, Adam L. and Jardri, Renaud and Noorani, Tehseen N. and others},
  title   = {{Visual Hallucinations in Serotonergic Psychedelics and Lewy Body Diseases}},
  journal = {Schizophrenia Bulletin},
  year    = {2025},
  doi     = {10.1093/schbul/sbaf068},
  pmid    = {41051875},
  url     = {https://doi.org/10.1093/schbul/sbaf068}
}

@article{zedde2025-40299513,
  author  = {Zedde, Marialuisa and Piazza, Fabrizio and Pascarella, Rosario},
  title   = {{Traumatic Brain Injury and Chronic Traumatic Encephalopathy: Not Only Trigger for Neurodegeneration but Also for Cerebral Amyloid Angiopathy?}},
  journal = {Biomedicines},
  year    = {2025},
  doi     = {10.3390/biomedicines13040881},
  pmid    = {40299513},
  url     = {https://doi.org/10.3390/biomedicines13040881}
}

@article{tseriotis2025-40244061,
  author  = {Tseriotis, Vasilis‐Spyridon and Liampas, Andreas and Lazaridou, Irene-Zacharo and Karachrysafi, Sofia and Vavougios, George D. and Hadjigeorgiou, Georgios M. and Papamitsou, Theodora and Kouvelas, Dimitrios and others},
  title   = {{Repulsive Guidance Molecule-A as a Therapeutic Target Across Neurological Disorders: An Update}},
  journal = {International Journal of Molecular Sciences},
  year    = {2025},
  doi     = {10.3390/ijms26073221},
  pmid    = {40244061},
  url     = {https://doi.org/10.3390/ijms26073221}
}

@article{shao2025-40145953,
  author  = {Shao, Qi and Chen, Simin and Zheng, Yuxiao and Xu, Wen‐Xiu and Chen, Jiahui and Shao, Wei Dong and Wang, Qingguo and Li, Changxiang and others},
  title   = {{Crucial role of microglia-mediated myelin sheath damage in vascular dementia: Antecedents and consequences}},
  journal = {Neural Regeneration Research},
  year    = {2025},
  doi     = {10.4103/nrr.nrr-d-24-01109},
  pmid    = {40145953},
  url     = {https://doi.org/10.4103/nrr.nrr-d-24-01109}
}

@article{yang2025-40136659,
  author  = {Yang, Yujie and Deng, Chunchu and Aldali, Fatima and Huang, Yunjie and Luo, Hong and Liu, Yizhou and Huang, Danxia and Cao, Xiaojian and others},
  title   = {{Therapeutic Approaches and Potential Mechanisms of Small Extracellular Vesicles in Treating Vascular Dementia}},
  journal = {Cells},
  year    = {2025},
  doi     = {10.3390/cells14060409},
  pmid    = {40136659},
  url     = {https://doi.org/10.3390/cells14060409}
}

@article{cao2025-39957423,
  author  = {Cao, Le and Wang, Hang and Hao, Jinkui and Kwapong, William Robert and Xiong, Zhouwei and Wang, Ruilin and Ye, Chen and Zhao, Yitian and others},
  title   = {{Lower Retinal Arteriolar Density Is Associated With Higher Cerebral Small Vessel Disease Burden: An Optical Coherence Tomography Angiography Study}},
  journal = {Brain and Behavior},
  year    = {2025},
  doi     = {10.1002/brb3.70342},
  pmid    = {39957423},
  url     = {https://doi.org/10.1002/brb3.70342}
}

@article{coles2025-39875340,
  author  = {Coles, Nathan P. and Elsheikh, Suzan and Quesnel, Agathe and Butler, Lucy and Jennings, Claire and Tarzi, Chaimaa and Achadu, Ojodomo J. and Islam, Meez and others},
  title   = {{Molecular Insights into α-Synuclein Fibrillation: A Raman Spectroscopy and Machine Learning Approach}},
  journal = {ACS Chemical Neuroscience},
  year    = {2025},
  doi     = {10.1021/acschemneuro.4c00726},
  pmid    = {39875340},
  url     = {https://doi.org/10.1021/acschemneuro.4c00726}
}

@article{kaufer2025-39973511,
  author  = {Käufer, Christopher and Stanojlović, Miloš and Schidlitzki, Alina and Bonsberger, Jana and Storch, Alexander and Richter, Franziska},
  title   = {{Alterations in non-REM sleep and EEG spectra precede REM-sleep deficits in a model of synucleinopathy}},
  journal = {Journal of Parkinson s Disease},
  year    = {2025},
  doi     = {10.1177/1877718x241310723},
  pmid    = {39973511},
  url     = {https://doi.org/10.1177/1877718x241310723}
}

@article{figliano2025-39892296,
  author  = {Figliano, Giusi and Miraglia, Laura and Manzi, Fatuma and Ruggerone, L and Nazzario, Matteo and Borgini, Irene and Donini, Massimo and Martellosio, V and others},
  title   = {{“Tom and Pepper Lab”. Robotics for cognitive stimulation and social skills: A preliminary study}},
  journal = {Asian Journal of Psychiatry},
  year    = {2025},
  doi     = {10.1016/j.ajp.2025.104375},
  pmid    = {39892296},
  url     = {https://doi.org/10.1016/j.ajp.2025.104375}
}

@article{alberti2025-39941343,
  author  = {Alberti, Giuseppe and Portelli, Daniele and Polito, Francesca and Graceffa, Anita Maria Stella and Licitri, Laura and Loteta, Sabrina and Torre, Margherita Maria and Gasparo, Irene and others},
  title   = {{Blood Neurofilament Light Chain and Phospho-Tau 181 in Subjects with Mild Cognitive Impairment Due to Age-Related Hearing Loss}},
  journal = {Journal of Clinical Medicine},
  year    = {2025},
  doi     = {10.3390/jcm14030672},
  pmid    = {39941343},
  url     = {https://doi.org/10.3390/jcm14030672}
}

@article{he2025-39786603,
  author  = {He, Puyi and Li, Xiaomei and Zou, Dan and Tang, Futian and Chen, Hao and Li, Yumin},
  title   = {{Environmental factors inducing gastric cancer: insights into risk and prevention strategies}},
  journal = {Discover Oncology},
  year    = {2025},
  doi     = {10.1007/s12672-025-01771-5},
  pmid    = {39786603},
  url     = {https://doi.org/10.1007/s12672-025-01771-5}
}

@article{khokhar2025-40487360,
  author  = {Khokhar, Sunil Kumar and Kumar, Manoj and Arshad, Faheem and Goyal, Sheetal and Tiwari, M. and Thanissery, Nithin and Ramakrishnan, Subasree and Nagaraj, Chandana and others},
  title   = {{Multiplex connectomics reveal altered networks in frontotemporal dementia: A multisite study}},
  journal = {Network Neuroscience},
  year    = {2025},
  doi     = {10.1162/netn_a_00448},
  pmid    = {40487360},
  url     = {https://doi.org/10.1162/netn_a_00448}
}

@article{fukumoto2024-39565643,
  author  = {Fukumoto, H. and Kao, T. H. and Tai, C. Y. and Jang, M. K. and Miyamoto, M.},
  title   = {{High-molecular-weight oligomer tau (HMWoTau) species are dramatically increased in Braak-stage dependent manner in the frontal lobe of human brains, demonstrated by a novel oligomer Tau ELISA with a mouse monoclonal antibody (APNmAb005)}},
  journal = {FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year    = {2024},
  doi     = {10.1096/fj.202401704r},
  pmid    = {39565643},
  url     = {https://doi.org/10.1096/fj.202401704r}
}

@article{michael2024-38924770,
  author  = {Michael, Faran and Dhiman, Ray and Shubhadeep, Nag and Umberto, Raucci and Michele, Parrinello and Gili, Bisker},
  title   = {{A Stochastic Landscape Approach for Protein Folding State Classification}},
  journal = {Journal of chemical theory and computation},
  year    = {2024},
  doi     = {10.1021/acs.jctc.4c00464},
  pmid    = {38924770},
  url     = {https://doi.org/10.1021/acs.jctc.4c00464}
}

@article{smart2023-37314125,
  author  = {Smart, C. D. and Fehrenbach, D. J. and Wassenaar, J. W. and Agrawal, V. and Fortune, N. L. and Dixon, D. D. and Cottam, M. A. and Hasty, A. H. and others},
  title   = {{Immune profiling of murine cardiac leukocytes identifies triggering receptor expressed on myeloid cells 2 as a novel mediator of hypertensive heart failure}},
  journal = {Cardiovascular research},
  year    = {2023},
  doi     = {10.1093/cvr/cvad093},
  pmid    = {37314125},
  url     = {https://doi.org/10.1093/cvr/cvad093}
}

@article{mitchell2022-36714789,
  author  = {Mitchell, C. and Gaitán, J. M. and Pewowaruk, R. J. and Gepner, A. D. and Hess, T. and Wilbrand, S. M. and Dempsey, R. J. and Dougherty, R. J. and others},
  title   = {{Transcranial Color-Coded Doppler Cerebral Hemodynamics Following Aerobic Exercise Training: Outcomes From a Pilot Randomized Clinical Trial}},
  journal = {Journal for vascular ultrasound : JVU},
  year    = {2022},
  doi     = {10.1177/15443167221099274},
  pmid    = {36714789},
  url     = {https://doi.org/10.1177/15443167221099274}
}

@article{chi2022-35963237,
  author  = {Chi, S. and Cui, Y. and Wang, H. and Jiang, J. and Zhang, T. and Sun, S. and Zhou, Z. and Zhong, Y. and others},
  title   = {{Astrocytic Piezo1-mediated mechanotransduction determines adult neurogenesis and cognitive functions}},
  journal = {Neuron},
  year    = {2022},
  doi     = {10.1016/j.neuron.2022.07.010},
  pmid    = {35963237},
  url     = {https://doi.org/10.1016/j.neuron.2022.07.010}
}

@article{spurrier2022-35648810,
  author  = {Spurrier, J. and Nicholson, L. and Fang, X. T. and Stoner, A. J. and Toyonaga, T. and Holden, D. and Siegert, T. R. and Laird, W. and others},
  title   = {{Reversal of synapse loss in Alzheimer mouse models by targeting mGluR5 to prevent synaptic tagging by C1Q}},
  journal = {Science translational medicine},
  year    = {2022},
  doi     = {10.1126/scitranslmed.abi8593},
  pmid    = {35648810},
  url     = {https://doi.org/10.1126/scitranslmed.abi8593}
}

@article{carson2022-35649655,
  author  = {Carson, R. E. and Naganawa, M. and Toyonaga, T. and Koohsari, S. and Yang, Y. and Chen, M. K. and Matuskey, D. and Finnema, S. J.},
  title   = {{Imaging of Synaptic Density in Neurodegenerative Disorders}},
  journal = {Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year    = {2022},
  doi     = {10.2967/jnumed.121.263201},
  pmid    = {35649655},
  url     = {https://doi.org/10.2967/jnumed.121.263201}
}

@article{ayoub2022-35137748,
  author  = {Ayoub, I. M. and George, M. Y. and Menze, E. T. and Mahmoud, M. and Botros, M. and Essam, M. and Ashmawy, I. and Shendi, P. and others},
  title   = {{Insights into the neuroprotective effects of Salvia officinalis L. and Salvia microphylla Kunth in the memory impairment rat model}},
  journal = {Food \& function},
  year    = {2022},
  doi     = {10.1039/d1fo02988f},
  pmid    = {35137748},
  url     = {https://doi.org/10.1039/d1fo02988f}
}

@article{mann2022-35171651,
  author  = {Mann, C. N. and Devi, S. S. and Kersting, C. T. and Bleem, A. V. and Karch, C. M. and Holtzman, D. M. and Gallardo, G.},
  title   = {{Astrocytic α2-Na+/K+ ATPase inhibition suppresses astrocyte reactivity and reduces neurodegeneration in a tauopathy mouse model}},
  journal = {Science translational medicine},
  year    = {2022},
  doi     = {10.1126/scitranslmed.abm4107},
  pmid    = {35171651},
  url     = {https://doi.org/10.1126/scitranslmed.abm4107}
}

@article{markovinovic2022-35129196,
  author  = {Markovinovic, A. and Greig, J. and Martín-Guerrero, S. M. and Salam, S. and Paillusson, S.},
  title   = {{Endoplasmic reticulum-mitochondria signaling in neurons and neurodegenerative diseases}},
  journal = {Journal of cell science},
  year    = {2022},
  doi     = {10.1242/jcs.248534},
  pmid    = {35129196},
  url     = {https://doi.org/10.1242/jcs.248534}
}

@article{fu2022-35091012,
  author  = {Fu, C. and Wu, Y. and Liu, S. and Luo, C. and Lu, Y. and Liu, M. and Wang, L. and Zhang, Y. and others},
  title   = {{Rehmannioside A improves cognitive impairment and alleviates ferroptosis via activating PI3K/AKT/Nrf2 and SLC7A11/GPX4 signaling pathway after ischemia}},
  journal = {Journal of ethnopharmacology},
  year    = {2022},
  doi     = {10.1016/j.jep.2022.115021},
  pmid    = {35091012},
  url     = {https://doi.org/10.1016/j.jep.2022.115021}
}

@article{ruganzu2022-34959070,
  author  = {Ruganzu, J. B. and Peng, X. and He, Y. and Wu, X. and Zheng, Q. and Ding, B. and Lin, C. and Guo, H. and others},
  title   = {{Downregulation of TREM2 expression exacerbates neuroinflammatory responses through TLR4-mediated MAPK signaling pathway in a transgenic mouse model of Alzheimer's disease}},
  journal = {Molecular immunology},
  year    = {2022},
  doi     = {10.1016/j.molimm.2021.12.018},
  pmid    = {34959070},
  url     = {https://doi.org/10.1016/j.molimm.2021.12.018}
}

@article{barker2021-34731014,
  author  = {Barker, S. J. and Raju, R. M. and Milman, N. E. P. and Wang, J. and Davila-Velderrain, J. and Gunter-Rahman, F. and Parro, C. C. and Bozzelli, P. L. and others},
  title   = {{MEF2 is a key regulator of cognitive potential and confers resilience to neurodegeneration}},
  journal = {Science translational medicine},
  year    = {2021},
  doi     = {10.1126/scitranslmed.abd7695},
  pmid    = {34731014},
  url     = {https://doi.org/10.1126/scitranslmed.abd7695}
}

@article{jiang2021-34453888,
  author  = {Jiang, L. and Lin, W. and Zhang, C. and Ash, P. E. A. and Verma, M. and Kwan, J. and van Vliet, E. and Yang, Z. and others},
  title   = {{Interaction of tau with HNRNPA2B1 and N6-methyladenosine RNA mediates the progression of tauopathy}},
  journal = {Molecular cell},
  year    = {2021},
  doi     = {10.1016/j.molcel.2021.07.038},
  pmid    = {34453888},
  url     = {https://doi.org/10.1016/j.molcel.2021.07.038}
}

@article{geula2021-34272732,
  author  = {Geula, C. and Dunlop, SR. and Ayala, I. and Kawles, A. S. and Flanagan, M. E. and Gefen, T. and Mesulam, M. M.},
  title   = {{Basal forebrain cholinergic system in the dementias: Vulnerability, resilience, and resistance}},
  journal = {Journal of neurochemistry},
  year    = {2021},
  doi     = {10.1111/jnc.15471},
  pmid    = {34272732},
  url     = {https://doi.org/10.1111/jnc.15471}
}

@article{lall2021-34133945,
  author  = {Lall, D. and Lorenzini, I. and Mota, T. A. and Bell, S. and Mahan, T. E. and Ulrich, J. D. and Davtyan, H. and Rexach, J. E. and others},
  title   = {{C9orf72 deficiency promotes microglial-mediated synaptic loss in aging and amyloid accumulation}},
  journal = {Neuron},
  year    = {2021},
  doi     = {10.1016/j.neuron.2021.05.020},
  pmid    = {34133945},
  url     = {https://doi.org/10.1016/j.neuron.2021.05.020}
}

@article{mirzaei2021-34243604,
  author  = {Mirzaei, R. and Bouzari, B. and Hosseini-Fard, SR. and Mazaheri, M. and Ahmadyousefi, Y. and Abdi, M. and Jalalifar, S. and others},
  title   = {{Role of microbiota-derived short-chain fatty acids in nervous system disorders}},
  journal = {Biomedicine \& pharmacotherapy = Biomedecine \& pharmacotherapie},
  year    = {2021},
  doi     = {10.1016/j.biopha.2021.111661},
  pmid    = {34243604},
  url     = {https://doi.org/10.1016/j.biopha.2021.111661}
}

@article{trudler2021-33483428,
  author  = {Trudler, D. and Sanz-Blasco, S. and Eisele, Y. S. and Ghatak, S. and Bodhinathan, K. and Akhtar, M. W. and Lynch, W. P. and Piña-Crespo, J. C. and others},
  title   = {{α-Synuclein Oligomers Induce Glutamate Release from Astrocytes and Excessive Extrasynaptic NMDAR Activity in Neurons, Thus Contributing to Synapse Loss}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2021},
  doi     = {10.1523/jneurosci.1871-20.2020},
  pmid    = {33483428},
  url     = {https://doi.org/10.1523/jneurosci.1871-20.2020}
}

@article{maornof2021-33482083,
  author  = {Maor-Nof, M. and Shipony, Z. and Lopez-Gonzalez, R. and Nakayama, L. and Zhang, Y. J. and Couthouis, J. and Blum, J. A. and Castruita, P. A. and others},
  title   = {{p53 is a central regulator driving neurodegeneration caused by C9orf72 poly(PR)}},
  journal = {Cell},
  year    = {2021},
  doi     = {10.1016/j.cell.2020.12.025},
  pmid    = {33482083},
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  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2021},
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@article{sun2020-33297569,
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@article{ali2021-33159979,
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  journal = {Neurochemistry international},
  year    = {2021},
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  title   = {{Hydroxytyrosol improves mitochondrial energetics of a cellular model of Alzheimer's disease}},
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@article{li2018-29655369,
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  title   = {{TREM2 regulates innate immunity in Alzheimer's disease}},
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  year    = {2018},
  doi     = {10.1186/s12974-018-1148-y},
  pmid    = {29655369},
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@article{hu2018-29051087,
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  title   = {{Triggering receptor expressed on myeloid cells 2 (TREM2) dependent microglial activation promotes cisplatin-induced peripheral neuropathy in mice}},
  journal = {Brain, behavior, and immunity},
  year    = {2018},
  doi     = {10.1016/j.bbi.2017.10.011},
  pmid    = {29051087},
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@article{castranio2017-28502803,
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  title   = {{Gene co-expression networks identify Trem2 and Tyrobp as major hubs in human APOE expressing mice following traumatic brain injury}},
  journal = {Neurobiology of disease},
  year    = {2017},
  doi     = {10.1016/j.nbd.2017.05.006},
  pmid    = {28502803},
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@article{zheng2017-28366226,
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  title   = {{Selective deletion of apolipoprotein E in astrocytes ameliorates the spatial learning and memory deficits in Alzheimer's disease (APP/PS1) mice by inhibiting TGF-β/Smad2/STAT3 signaling}},
  journal = {Neurobiology of aging},
  year    = {2017},
  doi     = {10.1016/j.neurobiolaging.2017.03.002},
  pmid    = {28366226},
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@article{imamura2016-27721502,
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  title   = {{Calcium dysregulation contributes to neurodegeneration in FTLD patient iPSC-derived neurons}},
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@article{hamblin2016-27752476,
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  title   = {{Shining light on the head: Photobiomodulation for brain disorders}},
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  year    = {2016},
  doi     = {10.1016/j.bbacli.2016.09.002},
  pmid    = {27752476},
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}

@article{silva2016-27594585,
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  title   = {{Human iPSC-Derived Neuronal Model of Tau-A152T Frontotemporal Dementia Reveals Tau-Mediated Mechanisms of Neuronal Vulnerability}},
  journal = {Stem cell reports},
  year    = {2016},
  doi     = {10.1016/j.stemcr.2016.08.001},
  pmid    = {27594585},
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}

@article{lovelace2016-27540379,
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  title   = {{Current Evidence for a Role of the Kynurenine Pathway of Tryptophan Metabolism in Multiple Sclerosis}},
  journal = {Frontiers in immunology},
  year    = {2016},
  doi     = {10.3389/fimmu.2016.00246},
  pmid    = {27540379},
  url     = {https://doi.org/10.3389/fimmu.2016.00246}
}

@article{kazim2016-27400746,
  author  = {Kazim, S. F. and Iqbal, K.},
  title   = {{Neurotrophic factor small-molecule mimetics mediated neuroregeneration and synaptic repair: emerging therapeutic modality for Alzheimer's disease}},
  journal = {Molecular neurodegeneration},
  year    = {2016},
  doi     = {10.1186/s13024-016-0119-y},
  pmid    = {27400746},
  url     = {https://doi.org/10.1186/s13024-016-0119-y}
}

@article{bodea2016-27306859,
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  title   = {{Tau physiology and pathomechanisms in frontotemporal lobar degeneration}},
  journal = {Journal of neurochemistry},
  year    = {2016},
  doi     = {10.1111/jnc.13600},
  pmid    = {27306859},
  url     = {https://doi.org/10.1111/jnc.13600}
}

@article{nakano2016-27102354,
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  title   = {{Bone marrow-derived mesenchymal stem cells improve diabetes-induced cognitive impairment by exosome transfer into damaged neurons and astrocytes}},
  journal = {Scientific reports},
  year    = {2016},
  doi     = {10.1038/srep24805},
  pmid    = {27102354},
  url     = {https://doi.org/10.1038/srep24805}
}

@article{kremmyda2016-27065838,
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  title   = {{Beyond Dizziness: Virtual Navigation, Spatial Anxiety and Hippocampal Volume in Bilateral Vestibulopathy}},
  journal = {Frontiers in human neuroscience},
  year    = {2016},
  doi     = {10.3389/fnhum.2016.00139},
  pmid    = {27065838},
  url     = {https://doi.org/10.3389/fnhum.2016.00139}
}

@article{antonenko2016-27047376,
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  title   = {{Hippocampal Pathway Plasticity Is Associated with the Ability to Form Novel Memories in Older Adults}},
  journal = {Frontiers in aging neuroscience},
  year    = {2016},
  doi     = {10.3389/fnagi.2016.00061},
  pmid    = {27047376},
  url     = {https://doi.org/10.3389/fnagi.2016.00061}
}

@article{elobeid2016-26979082,
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  title   = {{Altered Proteins in the Aging Brain}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2016},
  doi     = {10.1093/jnen/nlw002},
  pmid    = {26979082},
  url     = {https://doi.org/10.1093/jnen/nlw002}
}

@article{di2016-26888634,
  author  = {Di, J. and Cohen, L. S. and Corbo, C. P. and Phillips, G. R. and El Idrissi, A. and Alonso, A. D.},
  title   = {{Abnormal tau induces cognitive impairment through two different mechanisms: synaptic dysfunction and neuronal loss}},
  journal = {Scientific reports},
  year    = {2016},
  doi     = {10.1038/srep20833},
  pmid    = {26888634},
  url     = {https://doi.org/10.1038/srep20833}
}

@article{perezlloret2016-28725692,
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  title   = {{Deficits in cholinergic neurotransmission and their clinical correlates in Parkinson's disease}},
  journal = {NPJ Parkinson's disease},
  year    = {2016},
  doi     = {10.1038/npjparkd.2016.1},
  pmid    = {28725692},
  url     = {https://doi.org/10.1038/npjparkd.2016.1}
}

@article{barini2016-26858121,
  author  = {Barini, E. and Antico, O. and Zhao, Y. and Asta, F. and Tucci, V. and Catelani, T. and Marotta, R. and Xu, H. and others},
  title   = {{Metformin promotes tau aggregation and exacerbates abnormal behavior in a mouse model of tauopathy}},
  journal = {Molecular neurodegeneration},
  year    = {2016},
  doi     = {10.1186/s13024-016-0082-7},
  pmid    = {26858121},
  url     = {https://doi.org/10.1186/s13024-016-0082-7}
}

@article{siman2015-26540269,
  author  = {Siman, R. and Cocca, R. and Dong, Y.},
  title   = {{The mTOR Inhibitor Rapamycin Mitigates Perforant Pathway Neurodegeneration and Synapse Loss in a Mouse Model of Early-Stage Alzheimer-Type Tauopathy}},
  journal = {PloS one},
  year    = {2015},
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  pmid    = {26540269},
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}

@article{slevin2015-26335098,
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  title   = {{Monomeric C-reactive protein--a key molecule driving development of Alzheimer's disease associated with brain ischaemia?}},
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  year    = {2015},
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  pmid    = {26335098},
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@article{lucassen2015-26330520,
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  title   = {{Regulation of Adult Neurogenesis and Plasticity by (Early) Stress, Glucocorticoids, and Inflammation}},
  journal = {Cold Spring Harbor perspectives in biology},
  year    = {2015},
  doi     = {10.1101/cshperspect.a021303},
  pmid    = {26330520},
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@article{rocha2015-26094487,
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  title   = {{Sustained Systemic Glucocerebrosidase Inhibition Induces Brain α-Synuclein Aggregation, Microglia and Complement C1q Activation in Mice}},
  journal = {Antioxidants \& redox signaling},
  year    = {2015},
  doi     = {10.1089/ars.2015.6307},
  pmid    = {26094487},
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}

@article{ottum2015-26236094,
  author  = {Ottum, M. S. and Mistry, A. M.},
  title   = {{Advanced glycation end-products: modifiable environmental factors profoundly mediate insulin resistance}},
  journal = {Journal of clinical biochemistry and nutrition},
  year    = {2015},
  doi     = {10.3164/jcbn.15-3},
  pmid    = {26236094},
  url     = {https://doi.org/10.3164/jcbn.15-3}
}

@article{birnbaum2015-26086964,
  author  = {Birnbaum, J. H. and Bali, J. and Rajendran, L. and Nitsch, R. M. and Tackenberg, C.},
  title   = {{Calcium flux-independent NMDA receptor activity is required for Aβ oligomer-induced synaptic loss}},
  journal = {Cell death \& disease},
  year    = {2015},
  doi     = {10.1038/cddis.2015.160},
  pmid    = {26086964},
  url     = {https://doi.org/10.1038/cddis.2015.160}
}

@article{sephton2015-26047658,
  author  = {Sephton, C. F. and Yu, G.},
  title   = {{The function of RNA-binding proteins at the synapse: implications for neurodegeneration}},
  journal = {Cellular and molecular life sciences : CMLS},
  year    = {2015},
  doi     = {10.1007/s00018-015-1943-x},
  pmid    = {26047658},
  url     = {https://doi.org/10.1007/s00018-015-1943-x}
}

@article{jin2015-25918155,
  author  = {Jin, N. and Yin, X. and Gu, J. and Zhang, X. and Shi, J. and Qian, W. and Ji, Y. and Cao, M. and others},
  title   = {{Truncation and Activation of Dual Specificity Tyrosine Phosphorylation-regulated Kinase 1A by Calpain I: A MOLECULAR MECHANISM LINKED TO TAU PATHOLOGY IN ALZHEIMER DISEASE}},
  journal = {The Journal of biological chemistry},
  year    = {2015},
  doi     = {10.1074/jbc.m115.645507},
  pmid    = {25918155},
  url     = {https://doi.org/10.1074/jbc.m115.645507}
}

@article{fu2015-25814669,
  author  = {Fu, W. and Shi, D. and Westaway, D. and Jhamandas, J. H.},
  title   = {{Bioenergetic mechanisms in astrocytes may contribute to amyloid plaque deposition and toxicity}},
  journal = {The Journal of biological chemistry},
  year    = {2015},
  doi     = {10.1074/jbc.m114.618157},
  pmid    = {25814669},
  url     = {https://doi.org/10.1074/jbc.m114.618157}
}

@article{booij2015-25781010,
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  title   = {{DNA methylation of the serotonin transporter gene in peripheral cells and stress-related changes in hippocampal volume: a study in depressed patients and healthy controls}},
  journal = {PloS one},
  year    = {2015},
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  pmid    = {25781010},
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@article{harrington2015-25759392,
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  title   = {{Cellular Models of Aggregation-dependent Template-directed Proteolysis to Characterize Tau Aggregation Inhibitors for Treatment of Alzheimer Disease}},
  journal = {The Journal of biological chemistry},
  year    = {2015},
  doi     = {10.1074/jbc.m114.616029},
  pmid    = {25759392},
  url     = {https://doi.org/10.1074/jbc.m114.616029}
}

@article{hu2015-25871773,
  author  = {Hu, J. and Liu, C. C. and Chen, X. F. and Zhang, Y. W. and Xu, H. and Bu, G.},
  title   = {{Opposing effects of viral mediated brain expression of apolipoprotein E2 (apoE2) and apoE4 on apoE lipidation and Aβ metabolism in apoE4-targeted replacement mice}},
  journal = {Molecular neurodegeneration},
  year    = {2015},
  doi     = {10.1186/s13024-015-0001-3},
  pmid    = {25871773},
  url     = {https://doi.org/10.1186/s13024-015-0001-3}
}

@article{park2015-25615530,
  author  = {Park, J. S. and Ji, I. J. and An, H. J. and Kang, M. J. and Kang, S. W. and Kim, D. H. and Yoon, S. Y.},
  title   = {{Disease-Associated Mutations of TREM2 Alter the Processing of N-Linked Oligosaccharides in the Golgi Apparatus}},
  journal = {Traffic (Copenhagen, Denmark)},
  year    = {2015},
  doi     = {10.1111/tra.12264},
  pmid    = {25615530},
  url     = {https://doi.org/10.1111/tra.12264}
}

@article{wells2015-25700953,
  author  = {Wells, J. A. and O'Callaghan, J. M. and Holmes, H. E. and Powell, N. M. and Johnson, R. A. and Siow, B. and Torrealdea, F. and Ismail, O. and others},
  title   = {{In vivo imaging of tau pathology using multi-parametric quantitative MRI}},
  journal = {NeuroImage},
  year    = {2015},
  doi     = {10.1016/j.neuroimage.2015.02.023},
  pmid    = {25700953},
  url     = {https://doi.org/10.1016/j.neuroimage.2015.02.023}
}

@article{wilkins2015-25537010,
  author  = {Wilkins, H. M. and Carl, S. M. and Weber, S. G. and Ramanujan, S. A. and Festoff, B. W. and Linseman, D. A. and Swerdlow, R. H.},
  title   = {{Mitochondrial lysates induce inflammation and Alzheimer's disease-relevant changes in microglial and neuronal cells}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2015},
  doi     = {10.3233/jad-142334},
  pmid    = {25537010},
  url     = {https://doi.org/10.3233/jad-142334}
}

@article{yang2015-25483398,
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  title   = {{Perineuronal net digestion with chondroitinase restores memory in mice with tau pathology}},
  journal = {Experimental neurology},
  year    = {2015},
  doi     = {10.1016/j.expneurol.2014.11.013},
  pmid    = {25483398},
  url     = {https://doi.org/10.1016/j.expneurol.2014.11.013}
}

@article{lue2015-25281879,
  author  = {Lue, L. F. and Schmitz, C. and Walker, D. G.},
  title   = {{What happens to microglial TREM2 in Alzheimer's disease: Immunoregulatory turned into immunopathogenic?}},
  journal = {Neuroscience},
  year    = {2015},
  doi     = {10.1016/j.neuroscience.2014.09.050},
  pmid    = {25281879},
  url     = {https://doi.org/10.1016/j.neuroscience.2014.09.050}
}

@article{dai2015-25233799,
  author  = {Dai, C. L. and Chen, X. and Kazim, S. F. and Liu, F. and Gong, C. X. and Grundke-Iqbal, I. and Iqbal, K.},
  title   = {{Passive immunization targeting the N-terminal projection domain of tau decreases tau pathology and improves cognition in a transgenic mouse model of Alzheimer disease and tauopathies}},
  journal = {Journal of neural transmission (Vienna, Austria : 1996)},
  year    = {2015},
  doi     = {10.1007/s00702-014-1315-y},
  pmid    = {25233799},
  url     = {https://doi.org/10.1007/s00702-014-1315-y}
}

@article{mitsis2014-25226550,
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  title   = {{Tauopathy PET and amyloid PET in the diagnosis of chronic traumatic encephalopathies: studies of a retired NFL player and of a man with FTD and a severe head injury}},
  journal = {Translational psychiatry},
  year    = {2014},
  doi     = {10.1038/tp.2014.91},
  pmid    = {25226550},
  url     = {https://doi.org/10.1038/tp.2014.91}
}

@article{liu2014-25119742,
  author  = {Liu, C. G. and Song, J. and Zhang, Y. Q. and Wang, P. C.},
  title   = {{MicroRNA-193b is a regulator of amyloid precursor protein in the blood and cerebrospinal fluid derived exosomal microRNA-193b is a biomarker of Alzheimer's disease}},
  journal = {Molecular medicine reports},
  year    = {2014},
  doi     = {10.3892/mmr.2014.2484},
  pmid    = {25119742},
  url     = {https://doi.org/10.3892/mmr.2014.2484}
}

@article{park2015-25114293,
  author  = {Park, M. and Yi, J. W. and Kim, E. M. and Yoon, I. J. and Lee, E. H. and Lee, H. Y. and Ji, K. Y. and Lee, K. H. and others},
  title   = {{Triggering receptor expressed on myeloid cells 2 (TREM2) promotes adipogenesis and diet-induced obesity}},
  journal = {Diabetes},
  year    = {2015},
  doi     = {10.2337/db13-1869},
  pmid    = {25114293},
  url     = {https://doi.org/10.2337/db13-1869}
}

@article{kimura2014-25076872,
  author  = {Kimura, T. and Ishiguro, K. and Hisanaga, S.},
  title   = {{Physiological and pathological phosphorylation of tau by Cdk5}},
  journal = {Frontiers in molecular neuroscience},
  year    = {2014},
  doi     = {10.3389/fnmol.2014.00065},
  pmid    = {25076872},
  url     = {https://doi.org/10.3389/fnmol.2014.00065}
}

@article{grasso2014-24858274,
  author  = {Grasso, M. and Piscopo, P. and Confaloni, A. and Denti, M. A.},
  title   = {{Circulating miRNAs as biomarkers for neurodegenerative disorders}},
  journal = {Molecules (Basel, Switzerland)},
  year    = {2014},
  doi     = {10.3390/molecules19056891},
  pmid    = {24858274},
  url     = {https://doi.org/10.3390/molecules19056891}
}

@article{vargas2014-24658113,
  author  = {Vargas, L. M. and Leal, N. and Estrada, L. D. and González, A. and Serrano, F. and Araya, K. and Gysling, K. and Inestrosa, N. C. and others},
  title   = {{EphA4 activation of c-Abl mediates synaptic loss and LTP blockade caused by amyloid-β oligomers}},
  journal = {PloS one},
  year    = {2014},
  doi     = {10.1371/journal.pone.0092309},
  pmid    = {24658113},
  url     = {https://doi.org/10.1371/journal.pone.0092309}
}

@article{li2014-24603599,
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@article{peng2013-23962980,
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@article{walker2013-23847533,
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  title   = {{Canonical Wnt signaling protects hippocampal neurons from Aβ oligomers: role of non-canonical Wnt-5a/Ca(2+) in mitochondrial dynamics}},
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@article{hazrati2013-23745112,
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  title   = {{Absence of chronic traumatic encephalopathy in retired football players with multiple concussions and neurological symptomatology}},
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@article{ermak2013-23369757,
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  title   = {{Amyloid Oligomers Exacerbate Tau Pathology in a Mouse Model of Tauopathy}},
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  year    = {2012},
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@article{liu2008-18208556,
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  title   = {{Phosphorylated PP2A (tyrosine 307) is associated with Alzheimer neurofibrillary pathology}},
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  year    = {2008},
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@article{elliott2007-17954934,
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  year    = {2007},
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@article{becker2008-17893702,
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  title   = {{Repeated social defeat-induced depression-like behavioral and biological alterations in rats: involvement of cholecystokinin}},
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  title   = {{Higher frequency of regulatory T cells in the elderly and increased suppressive activity in neurodegeneration}},
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  year    = {2007},
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@article{hashimoto2007-17387318,
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  title   = {{Pituitary adenylate cyclase-activating polypeptide is associated with schizophrenia}},
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@article{carrera2006-16801643,
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  year    = {2006},
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  pmid    = {16801643},
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}

@article{vermetten2006-16585437,
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  title   = {{Hippocampal and amygdalar volumes in dissociative identity disorder}},
  journal = {The American journal of psychiatry},
  year    = {2006},
  doi     = {10.1176/ajp.2006.163.4.630},
  pmid    = {16585437},
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}

@article{galpern2006-16489609,
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  title   = {{Interface between tauopathies and synucleinopathies: a tale of two proteins}},
  journal = {Annals of neurology},
  year    = {2006},
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  pmid    = {16489609},
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}

@article{mcewen2006-17290796,
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  title   = {{Protective and damaging effects of stress mediators: central role of the brain}},
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  year    = {2006},
  doi     = {10.31887/dcns.2006.8.4/bmcewen},
  pmid    = {17290796},
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}

@article{morgan2005-16141783,
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  title   = {{Dynamic complexity of the microglial activation response in transgenic models of amyloid deposition: implications for Alzheimer therapeutics}},
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  year    = {2005},
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  pmid    = {16141783},
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@article{snyder2005-16025111,
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  title   = {{Regulation of NMDA receptor trafficking by amyloid-beta}},
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@article{mrak2004-15290893,
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  year    = {2004},
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@article{saykin2004-15140813,
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  title   = {{Cholinergic enhancement of frontal lobe activity in mild cognitive impairment}},
  journal = {Brain : a journal of neurology},
  year    = {2004},
  doi     = {10.1093/brain/awh177},
  pmid    = {15140813},
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@article{wu2004-15285800,
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  title   = {{Induction of serine racemase expression and D-serine release from microglia by amyloid beta-peptide}},
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  year    = {2004},
  doi     = {10.1186/1742-2094-1-2},
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@article{schultz2004-15123344,
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  title   = {{High prevalence of thorn-shaped astrocytes in the aged human medial temporal lobe}},
  journal = {Neurobiology of aging},
  year    = {2004},
  doi     = {10.1016/s0197-4580(03)00113-1},
  pmid    = {15123344},
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@article{hogg2003-12883828,
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  title   = {{The L266V tau mutation is associated with frontotemporal dementia and Pick-like 3R and 4R tauopathy}},
  journal = {Acta neuropathologica},
  year    = {2003},
  doi     = {10.1007/s00401-003-0734-x},
  pmid    = {12883828},
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@article{percy2003-12833399,
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  title   = {{Relation between apolipoprotein E genotype, hepatitis B virus status, and thyroid status in a sample of older persons with Down syndrome}},
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  year    = {2003},
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  pmid    = {12833399},
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@article{fuerst2003-12601713,
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  title   = {{Hippocampal sclerosis is a progressive disorder: a longitudinal volumetric MRI study}},
  journal = {Annals of neurology},
  year    = {2003},
  doi     = {10.1002/ana.10509},
  pmid    = {12601713},
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}

@article{redwine2003-12552120,
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  title   = {{Dentate gyrus volume is reduced before onset of plaque formation in PDAPP mice: a magnetic resonance microscopy and stereologic analysis}},
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  year    = {2003},
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@article{boeve2003-12584413,
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  title   = {{Progressive nonfluent aphasia and subsequent aphasic dementia associated with atypical progressive supranuclear palsy pathology}},
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  year    = {2003},
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@article{chaudhury2003-12528817,
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  title   = {{Neuregulin-1 and erbB4 immunoreactivity is associated with neuritic plaques in Alzheimer disease brain and in a transgenic model of Alzheimer disease}},
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  year    = {2003},
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@article{tschape2002-12456644,
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  title   = {{The neurodegeneration mutant löchrig interferes with cholesterol homeostasis and Appl processing}},
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@article{dhandapani2002-12390866,
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@article{apelt2002-12384234,
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@article{vanerp2002-12202271,
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  title   = {{Contributions of genetic risk and fetal hypoxia to hippocampal volume in patients with schizophrenia or schizoaffective disorder, their unaffected siblings, and healthy unrelated volunteers}},
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@article{vanderhart2002-12399945,
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  title   = {{Substance P receptor antagonist and clomipramine prevent stress-induced alterations in cerebral metabolites, cytogenesis in the dentate gyrus and hippocampal volume}},
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@article{schuff2001-11750891,
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@article{kuzuhara2001-11310628,
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  title   = {{Familial amyotrophic lateral sclerosis and parkinsonism-dementia complex of the Kii Peninsula of Japan: clinical and neuropathological study and tau analysis}},
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  title   = {{Amygdala and hippocampal volumes in children with Down syndrome: a high-resolution MRI study}},
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  year    = {2001},
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  journal = {Journal of investigative medicine : the official publication of the American Federation for Clinical Research},
  year    = {2001},
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@article{mehlhorn2000-10817926,
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@article{plassman1997-9109888,
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@article{bramlett1997-9039468,
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  title   = {{Convergence of neuroinflammation across major neurotropic viral exposomes in AD and ADRD}},
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@article{cao2026-42163676,
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  title   = {{High-definition Transcranial Direct Current Stimulation Improves Cognitive Function in Patients with Cerebral Small Vessel Disease: An Open-label Pilot Study Informed by Cross-sectional Analysis}},
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  year    = {2026},
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}

@article{shukla2026-42123310,
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  title   = {{Microglial Plasticity in Vascular Dementia: Mechanisms and Therapeutic Reprogramming}},
  journal = {International Journal of Molecular Sciences},
  year    = {2026},
  doi     = {10.3390/ijms27093719},
  pmid    = {42123310},
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}

@article{tramutola2026-42072161,
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  title   = {{Loss of Proteostasis and Early-Onset Neurodegeneration in Down Syndrome: From Mechanisms to Interventions}},
  journal = {Antioxidants (Basel, Switzerland)},
  year    = {2026},
  doi     = {10.3390/antiox15040520},
  pmid    = {42072161},
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}

@article{tramutola2026-08b5b6ac,
  author  = {Tramutola, A. and Lanzillotta, C. and Di Domenico, F. and Barone, E. and Perluigi, M.},
  title   = {{Loss of Proteostasis and Abnormal Aging in Down Syndrome: From Mechanisms to Interventions}},
  journal = {Antioxidants (Basel, Switzerland)},
  year    = {2026},
  doi     = {10.20944/preprints202603.1305.v1},
  url     = {https://doi.org/10.20944/preprints202603.1305.v1}
}

@article{chakraborty2026-41807755,
  author  = {Chakraborty, Anirban and Mitra, Joy and Malojirao, Vikas H. and Kodavati, Manohar M. and Mandal, Santi M. and Gill, Satkarjeet K. and Sreenivasmurthy, Sravan Gopalkrishnashetty and Vasquez, Velmarini and others},
  title   = {{Fructose-2,6-bisphosphate restores TDP-43 pathology-driven genome repair deficiency in motor neuron diseases}},
  journal = {Communications Biology},
  year    = {2026},
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  pmid    = {41807755},
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}

@article{draper2026-41525887,
  author  = {Draper, Derk and George, Anna E. and Veenendaal, Tineke and van Dijk, Suzanne M. and Soltani, Elly and Sanzà, Paolo and Verweij, Frederik J. and Klumperman, Judith and others},
  title   = {{HOPS disruption impairs APP trafficking and processing, promoting exosomal secretion of APP-CTFs}},
  journal = {Neurobiology of Disease},
  year    = {2026},
  doi     = {10.1016/j.nbd.2026.107269},
  pmid    = {41525887},
  url     = {https://doi.org/10.1016/j.nbd.2026.107269}
}

@article{eyamu2026-41583006,
  author  = {Eyamu, Joel and Ku, Boncho Uk and Kim, Kahye and Lee, Kun Ho and Kim, Jaeuk U.},
  title   = {{Aperiodic EEG signatures: unveiling the interplay between APOE ε4 and mild cognitive impairment subtypes}},
  journal = {Frontiers in Aging Neuroscience},
  year    = {2026},
  doi     = {10.3389/fnagi.2025.1675330},
  pmid    = {41583006},
  url     = {https://doi.org/10.3389/fnagi.2025.1675330}
}

@article{ciervo2026-41499526,
  author  = {Ciervo, Yuri and Rigoni, Pietro and Bucciarelli, Linda and Lombi, Martina and Pratesi, Federico and Bologna, Nadia and Accardo, Massimo and Recchi, Chiara and others},
  title   = {{Restoration of progranulin by engineered hematopoietic stem cell–derived microglia corrects phenotypes of granulin knockout mice}},
  journal = {Science Translational Medicine},
  year    = {2026},
  doi     = {10.1126/scitranslmed.adw9930},
  pmid    = {41499526},
  url     = {https://doi.org/10.1126/scitranslmed.adw9930}
}

@article{kandimalla2026-41574776,
  author  = {Kandimalla, Mahathi and Lim, Seokbeen and Jacobson, David N and Lee, Jeyeon and Min, Paul H. and Nycklemoe, Marin and Lee, Seung Baek and Lundt, Emily S. and others},
  title   = {{Neuroinflammation demonstrated by 11 C‐ER176 PET with amyloid and tau pathology}},
  journal = {Alzheimer s \& Dementia},
  year    = {2026},
  doi     = {10.1002/alz.71027},
  pmid    = {41574776},
  url     = {https://doi.org/10.1002/alz.71027}
}

@article{wadia2025-41448718,
  author  = {Wadia, Lyla and Garriga, Stella M. and Belliveau, Timothy and Arias, Franchesca and Carrión, Carmen I.},
  title   = {{Does Neighborhood Disadvantage Moderate the Relationship between Apolipoprotein E Status and Cognitive Functioning?}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70857_103936},
  pmid    = {41448718},
  url     = {https://doi.org/10.1002/alz70857_103936}
}

@article{akgun2025-41444117,
  author  = {Akgün, Bilçağ and Cornejo-Olivas, Mario R and Mena, Pedro Ramon and Adams, Larry Deon and Celis, Katrina and Whitehead, Patrice G. and Hamilton‐Nelson, Kara L. and Ríos‐Pinto, Julia and others},
  title   = {{Peruvian Population Empowers Discovery of a TREM2 Missense Variant in Alzheimer Disease}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70855_105970},
  pmid    = {41444117},
  url     = {https://doi.org/10.1002/alz70855_105970}
}

@article{tuil2025-41447298,
  author  = {Tuil, Marie Emilie and Allehyany, Bshaier and Punnota, Rifa Sanjida and Edison, Paul},
  title   = {{CSF sTREM2 is associated with distinct microglial responses with separate effects on Alzheimer's pathology in the disease's trajectory}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70856_100766},
  pmid    = {41447298},
  url     = {https://doi.org/10.1002/alz70856_100766}
}

@article{mclachlan2025-41450092,
  author  = {McLachlan, Max and DiFilippo, Alexandra H and Bettcher, Brecca and LeMerise, Lisette and McVea, Andrew K and Zammit, Matthew D. and Hartley, Sigan L. and Bendlin, Barbara B. and others},
  title   = {{Relationship between tau and SV2A in the neurotypical population and translation to the Down syndrome population}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70856_103321},
  pmid    = {41450092},
  url     = {https://doi.org/10.1002/alz70856_103321}
}

@article{mclachlan2025-41434190,
  author  = {McLachlan, Max and DiFilippo, Alexandra H and Bettcher, Brecca and LeMerise, Lisette and McVea, Andrew K and Zammit, Matthew D. and Hartley, Sigan L. and Bendlin, Barbara B. and others},
  title   = {{Relationship between tau and SV2A in the neurotypical population and translation to the Down syndrome population}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70862_110209},
  pmid    = {41434190},
  url     = {https://doi.org/10.1002/alz70862_110209}
}

@article{guerrero2025-41433957,
  author  = {Guerrero, Alejandro and Garcia‐Cifuentes, Elkin and Rodas-Marín, Jan Karlo and Baena, Ana Y. and Serna, Laura and Leon‐Varela, Yudy M and Duque, S Francisco Levi and Martínez, Juan F and others},
  title   = {{Phenotypic Characterization of Recently Identified PSEN1 Genetic Variants in ADAD in Colombia}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70861_108984},
  pmid    = {41433957},
  url     = {https://doi.org/10.1002/alz70861_108984}
}

@article{celis2025-41443185,
  author  = {Celis, Katrina and Griswold, Anthony J. and Rajabli, Farid and Ramírez, Aura María and Nam, Younji and Adams, Larry Deon and Whitehead, Patrice G. and Mena, Pedro Ramon and others},
  title   = {{Transcriptomic analysis from 3D cultures of Presilinin‐1 G206A carriers reveals genetic expression differences associated with age‐of‐onset variability}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70855_104923},
  pmid    = {41443185},
  url     = {https://doi.org/10.1002/alz70855_104923}
}

@article{agarwal2025-41434452,
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  title   = {{The MIND diet association with lower microglial inflammation in the hippocampus: A Community‐Based Neuropathologic Study}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70860_100482},
  pmid    = {41434452},
  url     = {https://doi.org/10.1002/alz70860_100482}
}

@article{oportocolicoi2025-41303517,
  author  = {Oporto-Colicoi, Valeria and Sepúlveda-Lara, Alexis and Marzuca-Nassr, Gabriel Nasri and Sepúlveda-Figueroa, Paulina},
  title   = {{Mild Cognitive Impairment and Sarcopenia: Effects of Resistance Exercise Training on Neuroinflammation, Cognitive Performance, and Structural Brain Changes}},
  journal = {International Journal of Molecular Sciences},
  year    = {2025},
  doi     = {10.3390/ijms262211036},
  pmid    = {41303517},
  url     = {https://doi.org/10.3390/ijms262211036}
}

@article{boreland2025-41205777,
  author  = {Boreland, Andrew J. and Abbo, Yara and Li, Xindi and Stillitano, Alessandro C. and Zhang, Siwei and Duan, Jubao and Pang, Zhiping P. and Hart, Ronald P.},
  title   = {{Ethanol induces neuroimmune dysregulation and soluble TREM2 generation in a human iPSC neuron, astrocyte, microglia triculture model}},
  journal = {Alcohol},
  year    = {2025},
  doi     = {10.1016/j.alcohol.2025.10.006},
  pmid    = {41205777},
  url     = {https://doi.org/10.1016/j.alcohol.2025.10.006}
}

@article{choe2025-41204331,
  author  = {Choe, Kyonghwan and Ahmad, Riaz and Kang, Min Hwa and Lee, Hyeon Jin and Ahmad, Sareer and Park, Tae Ju and Kim, Myeong Ok},
  title   = {{The novel sphingolipids cP1P and P1P attenuate neuroinflammation and enhance S1PR1/Akt/mTOR signaling to mitigate cognitive decline in an Alzheimer’s disease mouse model}},
  journal = {Cell Communication and Signaling},
  year    = {2025},
  doi     = {10.1186/s12964-025-02485-5},
  pmid    = {41204331},
  url     = {https://doi.org/10.1186/s12964-025-02485-5}
}

@article{zupan2025-41281549,
  author  = {Zupan, Matija and Splavski, Bruno and Frol, Senta},
  title   = {{Iatrogenic cerebral proteinopathies—The dawn of transmissible neurodegeneration? The example of cerebral amyloid angiopathy}},
  journal = {Frontiers in Neurology},
  year    = {2025},
  doi     = {10.3389/fneur.2025.1693566},
  pmid    = {41281549},
  url     = {https://doi.org/10.3389/fneur.2025.1693566}
}

@article{espejo2025-561ddaf5,
  author  = {Espejo, Nuria H. and Feito, Alejandro and Sanchez‐Burgos, Ignacio and Garaizar, Adiran and Conde, M. M. and Rey, Antonio and Pedraza, Eduardo and Castro, Alejandro and others},
  title   = {{Compositional Control of Aging Kinetics in TDP-43 Condensates}},
  journal = {PRX Life},
  year    = {2025},
  doi     = {10.1103/w7g3-6rsd},
  url     = {https://doi.org/10.1103/w7g3-6rsd}
}

@article{ye2025-41074912,
  author  = {Ye, Rong and Goodheart, Anna E. and Locascio, Joseph J. and Peterec, Erin and Stancu, Patrick and Wang, Yanhong and Gomperts, Stephen N.},
  title   = {{APOE ε4 linked effects on clinical features and neuropathology in dementia with Lewy bodies}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz.70795},
  pmid    = {41074912},
  url     = {https://doi.org/10.1002/alz.70795}
}

@article{liu2025-41013506,
  author  = {Liu, Jiahui and Zaidi, Ali Hussainy and Pike, Christian J.},
  title   = {{Microglia/macrophage-specific deletion of TLR-4 protects against neural effects of diet-induced obesity in a sexually dimorphic manner}},
  journal = {Journal of Neuroinflammation},
  year    = {2025},
  doi     = {10.1186/s12974-025-03534-z},
  pmid    = {41013506},
  url     = {https://doi.org/10.1186/s12974-025-03534-z}
}

@article{huber2025-41006764,
  author  = {Huber, Nadine and Hietanen, Tomi and Heikkinen, Sami and Shakirzyanova, Anastasia and Hoffmann, Dorit B. and Rostalski, Hannah and Dhingra, Ashutosh and Rodriguez-Nieto, Salvador and others},
  title   = {{Frontotemporal dementia patient-derived iPSC neurons show cell pathological hallmarks and evidence for synaptic dysfunction and DNA damage}},
  journal = {Molecular Psychiatry},
  year    = {2025},
  doi     = {10.1038/s41380-025-03272-x},
  pmid    = {41006764},
  url     = {https://doi.org/10.1038/s41380-025-03272-x}
}

@article{salzano2025-40972833,
  author  = {Salzano, Sara and Bertasini, Chiara and Haghighi, Shima Tavakolian and Lundkvist, Johan and Wahlberg, Lars U. and Chiamulera, Cristiano and Vattemi, Gaetano Nicola Alfio and Gardoni, Fabrizio and others},
  title   = {{Frontotemporal dementia as a consequence of GRN mutations: From disease cause to models to therapies}},
  journal = {Pharmacological Research},
  year    = {2025},
  doi     = {10.1016/j.phrs.2025.107957},
  pmid    = {40972833},
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}

@article{fu2025-40969184,
  author  = {Fu, Pan and Hu, Meiling},
  title   = {{Associations of plasma von Willebrand Factor levels with cognitive decline and neurodegeneration in older adults without dementia}},
  journal = {Frontiers in Aging Neuroscience},
  year    = {2025},
  doi     = {10.3389/fnagi.2025.1595071},
  pmid    = {40969184},
  url     = {https://doi.org/10.3389/fnagi.2025.1595071}
}

@article{wang2025-40905109,
  author  = {Wang, Yuying and Gao, Yang and Wang, Yarong and Zhang, Fuqiang and Sun, Fei and Wang, Xin and Xie, Jiazhao and Xu, Zhipeng and others},
  title   = {{ApoE4 Upregulates GSK ‐3β to Aggravate Alzheimer‐Like Pathologies and Cognitive Impairment in Type 2 Diabetic Mice}},
  journal = {CNS Neuroscience \& Therapeutics},
  year    = {2025},
  doi     = {10.1111/cns.70575},
  pmid    = {40905109},
  url     = {https://doi.org/10.1111/cns.70575}
}

@article{mearelli2025-40888599,
  author  = {Mearelli, Marika and Hirschberg, Insa and Weissleder, Christin and Giachino, Carmela and Maria Jose Perez, J. and Dubroux, Malvina and Provenzano, Francesca and Rizzuti, Mafalda and others},
  title   = {{C9orf72 Repeat Expansion Induces Metabolic Dysfunction in Human iPSC ‐Derived Microglia and Modulates Glial‐Neuronal Crosstalk}},
  journal = {Glia},
  year    = {2025},
  doi     = {10.1002/glia.70080},
  pmid    = {40888599},
  url     = {https://doi.org/10.1002/glia.70080}
}

@article{carnicerosenabre2025-40902316,
  author  = {Carnicero-Senabre, Daniel and Barata, Mariana Afonso and Jiménez-Villegas, José and Almeida, Cláudia Guimas and Cuadrado, Antonio and Rojo, Ana Isabel},
  title   = {{NRF2 deficiency is associated with synaptic alterations and ether-linked phospholipid imbalance in the hippocampus}},
  journal = {Redox Biology},
  year    = {2025},
  doi     = {10.1016/j.redox.2025.103853},
  pmid    = {40902316},
  url     = {https://doi.org/10.1016/j.redox.2025.103853}
}

@article{calderongarciduenas2025-40803397,
  author  = {Calderón-Garcidueñas, Lilian and Cejudo, Rubén and González-Maciel, Angélica and Reynoso-Robles, Rafael and Ramos-Morales, Andrea and Pérez-Guillé, Beatríz and Soriano‐Rosales, Rosa Eugenia and Torres‐Jardón, Ricardo},
  title   = {{Cardiovascular damage, arrhythmogenesis and overlapping Alzheimer and Parkinson's diseases and TDP-43 pathology start in pediatric and young adult urban populations: Magnetic ultrafine particulate matter and industrial particles with motion behavior play a key role}},
  journal = {Environmental Research},
  year    = {2025},
  doi     = {10.1016/j.envres.2025.122558},
  pmid    = {40803397},
  url     = {https://doi.org/10.1016/j.envres.2025.122558}
}

@article{sathyaseelan2025-40770913,
  author  = {Sathyaseelan, Chakkarai and Le Grand, Quentin and Shaoxuan, Lucas Wang and Debette, Stéphanie and Sargurupremraj, Muralidharan},
  title   = {{Unravelling the genetic architecture of cerebral small vessel disease in the context of stroke}},
  journal = {Journal of Cerebral Blood Flow \& Metabolism},
  year    = {2025},
  doi     = {10.1177/0271678x251362977},
  pmid    = {40770913},
  url     = {https://doi.org/10.1177/0271678x251362977}
}

@article{cordella2025-40810332,
  author  = {Cordella, Federica and Mautone, Lorenza and Salerno, Debora and Tondo, Lucrezia and Ghirga, Silvia and D’Antoni, Chiara and Parente, Erika and Romeo, Maria Anele and others},
  title   = {{Bezafibrate treatment rescues neurodevelopmental and neurodegenerative defects in 3D cortical organoid model of MAPT frontotemporal dementia}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz.70419},
  pmid    = {40810332},
  url     = {https://doi.org/10.1002/alz.70419}
}

@article{colwell2025-40771194,
  author  = {Colwell, Julia C. and Emborg, Marina Elena},
  title   = {{Tau and tauopathies across primate species: implications for modeling neurodegenerative disorders}},
  journal = {Frontiers in Aging Neuroscience},
  year    = {2025},
  doi     = {10.3389/fnagi.2025.1598245},
  pmid    = {40771194},
  url     = {https://doi.org/10.3389/fnagi.2025.1598245}
}

@article{sun2025-40718100,
  author  = {Sun, Kedi and Liu, Hui},
  title   = {{Emerging biomarkers and frontier therapies: unveiling the role of endothelial dysfunction in cerebral small vessel disease}},
  journal = {Frontiers in Neurology},
  year    = {2025},
  doi     = {10.3389/fneur.2025.1615883},
  pmid    = {40718100},
  url     = {https://doi.org/10.3389/fneur.2025.1615883}
}

@article{krick2025-40602729,
  author  = {Krick, Katelynn E. and Weekman, Erica M. and Johnson, Sherika N. and Sudduth, Tiffany L. and Rogers, Colin B. and Nicolayson, Emma J and Kleinhenz, Maureen T. and Wilcock, Donna M.},
  title   = {{Age-related cerebral amyloid angiopathy accumulation in the APPSw mouse model is associated with perivascular inflammation and brain-wide vascular and inflammatory gene and protein changes}},
  journal = {Neurobiology of Disease},
  year    = {2025},
  doi     = {10.1016/j.nbd.2025.107013},
  pmid    = {40602729},
  url     = {https://doi.org/10.1016/j.nbd.2025.107013}
}

@article{nicholls2025-1226f07b,
  author  = {Nicholls, Laura E. and Nimmo, Jacqui and Cooke, Rebekah S. and Baggott, Taine J. and Bright, Matthew and Byrne, Robert A.J. and Fenn, Gareth D. and Keat, Samuel and others},
  title   = {{C3 and C3a as indicators of complement dysregulation in tauopathies and FTLD-associated disorders}},
  journal = {Immunobiology},
  year    = {2025},
  doi     = {10.1016/j.imbio.2025.152946},
  url     = {https://doi.org/10.1016/j.imbio.2025.152946}
}

@article{akter2025-40649239,
  author  = {Akter, Sharmin and Tohge, Takayuki and Ananda, Sahithya Hulimane and Kuragano, Masahiro and Tokuraku, Kiyotaka and Uwai, Koji},
  title   = {{Anti-Amyloid Aggregation Effects of Gobaishi (Galla chinensis) and Its Active Constituents}},
  journal = {Molecules},
  year    = {2025},
  doi     = {10.3390/molecules30132720},
  pmid    = {40649239},
  url     = {https://doi.org/10.3390/molecules30132720}
}

@article{ochneva2025-40518820,
  author  = {Ochneva, Aleksandra and Zakurazhnaya, Valeriya and Zorkina, Yana and Abramova, Olga V. and Ushakova, Valeriya M. and Tsurina, Anna M. and Golubeva, Elizaveta and Gurina, Olga Ivanovna and others},
  title   = {{The increase in TDP-43 and neurogranin blood levels at different stages of cognitive impairment in the elderly people: A cross-sectional study}},
  journal = {Journal of Alzheimer s Disease},
  year    = {2025},
  doi     = {10.1177/13872877251350385},
  pmid    = {40518820},
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}

@article{gonzalezperez2025-40494433,
  author  = {González Pérez, N. and Bellotto, M. and Porte Alcón, S. and Bentivegna, M. and Arcucci, L. and Á, Vinuesa and Presa, J. and Brites, F. and others},
  title   = {{Metformin protects against insulin resistance-related dementia risk involving restored microglial homeostasis}},
  journal = {Life sciences},
  year    = {2025},
  doi     = {10.1016/j.lfs.2025.123803},
  pmid    = {40494433},
  url     = {https://doi.org/10.1016/j.lfs.2025.123803}
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@article{kim2025-40431734,
  author  = {Kim, Dong‐Hwi and Kim, Dong-Hwi and Kim, Jae‐Hyeong and Jeon, Min‐Tae and Kim, Kyu‐Sung and Kim, Do-Geun and Choi, In-Soo},
  title   = {{The Role of TDP-43 in SARS-CoV-2-Related Neurodegenerative Changes}},
  journal = {Viruses},
  year    = {2025},
  doi     = {10.3390/v17050724},
  pmid    = {40431734},
  url     = {https://doi.org/10.3390/v17050724}
}

@article{zhou2025-40339618,
  author  = {Zhou, Constance Q. and Hardin, Evelyn J. and Zimmer, Till S. and Jackvony, Stephanie and BARNETT, DANIEL H. and Khobrekar, Noopur V. and Giacomelli, Elisa and Studer, Lorenz and others},
  title   = {{Neuroimmune signaling mediates astrocytic nucleocytoplasmic disruptions and stress granule formation associated with TDP-43 pathology}},
  journal = {Neurobiology of Disease},
  year    = {2025},
  doi     = {10.1016/j.nbd.2025.106939},
  pmid    = {40339618},
  url     = {https://doi.org/10.1016/j.nbd.2025.106939}
}

@article{abdellah2025-40325262,
  author  = {Abdel-Lah, Ebtsam S and Sherkawy, Hoda S. and Mohamed, Wafaa H. and Fawy, Mariam A. and Hasan, Asmaa A. and Muhammed, Asmaa A. and Taha, Amira F. and Tony, Abeer A. and others},
  title   = {{Empagliflozin and memantine combination ameliorates cognitive impairment in scopolamine + heavy metal mixture-induced Alzheimer’s disease in rats: role of AMPK/mTOR, BDNF, BACE-1, neuroinflammation, and oxidative stress}},
  journal = {Inflammopharmacology},
  year    = {2025},
  doi     = {10.1007/s10787-025-01755-5},
  pmid    = {40325262},
  url     = {https://doi.org/10.1007/s10787-025-01755-5}
}

@article{morito2025-40220760,
  author  = {Morito, Takahiro and Qi, Meng and Kamano, Naoko and Sasaguri, Hiroki and Bez, Sumi and Foiani, Martha S. and Duff, Karen and Benner, Seico and others},
  title   = {{Human MAPT knockin mouse models of frontotemporal dementia for the neurodegenerative research community}},
  journal = {Cell Reports Methods},
  year    = {2025},
  doi     = {10.1016/j.crmeth.2025.101024},
  pmid    = {40220760},
  url     = {https://doi.org/10.1016/j.crmeth.2025.101024}
}

@article{zhao2025-40145977,
  author  = {Zhao, Wenhui and Liu, Zhongxuan and Wu, Jiannan and Liu, Anran and Yan, Junqiang},
  title   = {{Potential targets of microglia in the treatment of neurodegenerative diseases: Mechanism and therapeutic implications}},
  journal = {Neural Regeneration Research},
  year    = {2025},
  doi     = {10.4103/nrr.nrr-d-24-01343},
  pmid    = {40145977},
  url     = {https://doi.org/10.4103/nrr.nrr-d-24-01343}
}

@article{downs2025-40122182,
  author  = {Downs, Anthony M. and Kmiec, Gracianne E. and Catavero, Christina M. and Wykoff, Luke A. and McElligott, Zoé A.},
  title   = {{Loss of excitatory inputs and decreased tonic and evoked activity of locus coeruleus neurons in aged P301S mice}},
  journal = {Neurobiology of Disease},
  year    = {2025},
  doi     = {10.1016/j.nbd.2025.106883},
  pmid    = {40122182},
  url     = {https://doi.org/10.1016/j.nbd.2025.106883}
}

@article{gliaudelyte2025-40113786,
  author  = {Gliaudelytė, Lina and Rushton, Steven and Palmini, Rolando Berlinguer and Thomas, Alan J. and Morris, Christopher M.},
  title   = {{Dopaminergic changes in the subgenual cingulate cortex in dementia with lewy bodies associates with presence of depression}},
  journal = {Translational Psychiatry},
  year    = {2025},
  doi     = {10.1038/s41398-025-03298-3},
  pmid    = {40113786},
  url     = {https://doi.org/10.1038/s41398-025-03298-3}
}

@article{chen2025-40141445,
  author  = {Chen, Danni and Fasina, Opeyemi B. and Lin, Jiahui and Zeng, Jiayuan and Manzoor, Majid and Ohno, Hiroshi and Xiang, Lan and Qi, Jianhua},
  title   = {{TBG096 Ameliorates Memory Deficiency in AD Mouse Model via Promoting Neurogenesis and Regulation of Hsc70/HK2/PKM2/LAMP2A Signaling Pathway}},
  journal = {International Journal of Molecular Sciences},
  year    = {2025},
  doi     = {10.3390/ijms26062804},
  pmid    = {40141445},
  url     = {https://doi.org/10.3390/ijms26062804}
}

@article{liu2025-40081583,
  author  = {Liu, Jia and Li, Zhaoqing},
  title   = {{Autoimmune thyroid disease is a risk factor for mood disorders, a Mendelian randomization study}},
  journal = {Journal of Affective Disorders},
  year    = {2025},
  doi     = {10.1016/j.jad.2025.03.033},
  pmid    = {40081583},
  url     = {https://doi.org/10.1016/j.jad.2025.03.033}
}

@article{lee2025-40075889,
  author  = {Lee, Ryung S. and Kumar, Rahul and Weaver, Alex C. and Kim, Ji Hyun and Raza, Arriyan and Ong, Joshua and Waisberg, Ethan and Pandit, Rahul T.},
  title   = {{Cornea Oculomics: A Clinical Blueprint for Extending Corneal Diagnostics and Artificial Intelligence in Systemic Health Insights}},
  journal = {Diagnostics},
  year    = {2025},
  doi     = {10.3390/diagnostics15050643},
  pmid    = {40075889},
  url     = {https://doi.org/10.3390/diagnostics15050643}
}

@article{bentum2025-6fba29c0,
  author  = {Bentum, Kingsley E. and Kuufire, Emmanuel and Nyarku, Rejoice and Osei, Viona and Price, Stuart B. and Bourassa, Dianna V. and Samuel, Temesgen and Jackson, Charlene R. and others},
  title   = {{Salmonellosis in Cattle: Sources and Risk of Infection, Control, and Prevention}},
  journal = {Zoonotic Diseases},
  year    = {2025},
  doi     = {10.3390/zoonoticdis5010004},
  url     = {https://doi.org/10.3390/zoonoticdis5010004}
}

@article{arafi2025-99d20e91,
  author  = {Arafi, Parnian and Devkota, Sujan and Williams, Emily L. and Maesako, Masato and Wolfe, Michael S.},
  title   = {{Alzheimer-mutant γ-secretase complexes stall amyloid β-peptide production}},
  journal = {eLife},
  year    = {2025},
  doi     = {10.7554/elife.102274.3},
  url     = {https://doi.org/10.7554/elife.102274.3}
}

@article{mengr2025-39932627,
  author  = {Mengr, Anna and Šmotková, Zuzana and Pačesová, Andrea and Železná, Blanka and Kuneš, Jaroslav and Maletı́nská, Lenka},
  title   = {{Reduction of Neuroinflammation as a Common Mechanism of Action of Anorexigenic and Orexigenic Peptide Analogues in the Triple Transgenic Mouse Model of Alzheimer´s Disease}},
  journal = {Journal of Neuroimmune Pharmacology},
  year    = {2025},
  doi     = {10.1007/s11481-025-10174-w},
  pmid    = {39932627},
  url     = {https://doi.org/10.1007/s11481-025-10174-w}
}

@article{fischer2025-39838428,
  author  = {Fischer, D. Luke and Menard, Marissa A. and Abdelaziz, Omar Z. and Kanaan, Nicholas M. and Cobbs, Virginia G. and Kennedy, Richard and Serrano, Geidy E. and Beach, Thomas G. and others},
  title   = {{Distinct subcellular localization of tau and alpha-synuclein in lewy body disease}},
  journal = {Acta Neuropathologica Communications},
  year    = {2025},
  doi     = {10.1186/s40478-024-01913-w},
  pmid    = {39838428},
  url     = {https://doi.org/10.1186/s40478-024-01913-w}
}

@article{chen2025-40630682,
  author  = {Chen, Xi and Chen, Silu and Chen, Liangliang and Zheng, Hong and Nie, Jing and Yang, Lingyan and Li, Xia and Ju, Kang},
  title   = {{Profiling characteristics of plasma exosomal miRNAs across cognitive stages: from normalcy to mild cognitive impairment and Alzheimer's disease}},
  journal = {RSC Advances},
  year    = {2025},
  doi     = {10.1039/d5ra02993g},
  pmid    = {40630682},
  url     = {https://doi.org/10.1039/d5ra02993g}
}

@article{hong2025-da1417b6,
  author  = {Hong and Jihyun and An and Hyun-kyu and Nam and Hyeri and Choi and Jieun and others},
  title   = {{Presenilin 2 regulates corticosterone-induced autophagic death of adult hippocampal neural stem cells}},
  journal = {Figshare},
  year    = {2025},
  doi     = {10.6084/m9.figshare.30753007.v1},
  url     = {https://doi.org/10.6084/m9.figshare.30753007.v1}
}

@article{lu2025-8a2dac90,
  author  = {Lu and Jiayi and Florio, Di and Damian, N. and Boya and Patricia and Maday and Sandra and others},
  title   = {{Autophagy and mitophagy at the synapse and beyond: implications for learning, memory and neurological disorders}},
  journal = {Figshare},
  year    = {2025},
  doi     = {10.6084/m9.figshare.30691938.v1},
  url     = {https://doi.org/10.6084/m9.figshare.30691938.v1}
}

@article{kapoor2025-40034682,
  author  = {Kapoor, Arunima and Dutt, Shubir and Nguyen, Amy and Lohman, Trevor and Gaubert, Aimée and Alitin, John Paul M and Sible, Isabel J. and Marshall, Anisa J. and others},
  title   = {{Endothelial progenitor cells and cerebral small vessel disease in APOE4 carriers}},
  journal = {Cerebral Circulation - Cognition and Behavior},
  year    = {2025},
  doi     = {10.1016/j.cccb.2025.100378},
  pmid    = {40034682},
  url     = {https://doi.org/10.1016/j.cccb.2025.100378}
}

@article{boyle2024-5a1c3594,
  author  = {Boyle, Rory Thomas and Dehghani, Nadia and Stites, Shana D. and Nelson, Sacha B. and Irwin, David John and McMillan, Corey T. and Massimo, Lauren M.},
  title   = {{Greater neighborhood deprivation is related to shorter survival in behavioral‐variant frontotemporal degeneration}},
  journal = {Alzheimer s \& Dementia},
  year    = {2024},
  doi     = {10.1002/alz.095411},
  url     = {https://doi.org/10.1002/alz.095411}
}

@article{zhang2024-39448576,
  author  = {Zhang, R. and Ohshima, M. and Brodin, D. and Wang, Y. and Morancé, A. and Schultzberg, M. and Chen, G. and Johansson, J.},
  title   = {{Intravenous chaperone treatment of late-stage Alzheimer´s disease (AD) mouse model affects amyloid plaque load, reactive gliosis and AD-related genes}},
  journal = {Translational psychiatry},
  year    = {2024},
  doi     = {10.1038/s41398-024-03161-x},
  pmid    = {39448576},
  url     = {https://doi.org/10.1038/s41398-024-03161-x}
}

@article{sushma2024-38143280,
  author  = {Sushma and Sahu, M. R. and Murugan, N. A. and Mondal, A. C.},
  title   = {{Amelioration of Amyloid-β Induced Alzheimer's Disease by Bacopa monnieri through Modulation of Mitochondrial Dysfunction and GSK-3β/Wnt/β-Catenin Signaling}},
  journal = {Molecular nutrition \& food research},
  year    = {2024},
  doi     = {10.1002/mnfr.202300245},
  pmid    = {38143280},
  url     = {https://doi.org/10.1002/mnfr.202300245}
}

@article{housini2023-bed5ab2c,
  author  = {Housini, Mohammad and Zhou, Zhengyang and Kind, Amy and Reid, Danielle Marie and Daniel, Ann Abraham and Silzer, Talisa K. and O’Bryant, Sid E. and Phillips, Nicole and others},
  title   = {{Interaction between DNA methylation and neighborhood disadvantage may impact risk for cognitive decline among Mexican Americans enrolled in the Health and Aging Brain Study – Health Disparities (HABS‐HD) Cohort}},
  journal = {Alzheimer s \& Dementia},
  year    = {2023},
  doi     = {10.1002/alz.080609},
  url     = {https://doi.org/10.1002/alz.080609}
}

@article{rustamzadeh2023-38318412,
  author  = {Rustamzadeh, A. and Sadigh, N. and Shabani, R. and Ahadi, R. and Vahabi, Z. and Shabani, A. and Mohebi, N. and Khamseh, F. and others},
  title   = {{Neurochemical Ameliorating of the Hippocampus in Dyslipidemic Alzheimer Patients Following Silymarin; a Double-Blind Placebo-Controlled Randomized Clinical Trial}},
  journal = {Medical journal of the Islamic Republic of Iran},
  year    = {2023},
  doi     = {10.47176/mjiri.37.123},
  pmid    = {38318412},
  url     = {https://doi.org/10.47176/mjiri.37.123}
}

@article{czerminski2022-36817096,
  author  = {Czerminski, J. T. and King, O. D. and Lawrence, J. B.},
  title   = {{Large-scale organoid study suggests effects of trisomy 21 on early fetal neurodevelopment are more subtle than variability between isogenic lines and experiments}},
  journal = {Frontiers in neuroscience},
  year    = {2022},
  doi     = {10.3389/fnins.2022.972201},
  pmid    = {36817096},
  url     = {https://doi.org/10.3389/fnins.2022.972201}
}

@article{pacia2023-36719290,
  author  = {Pacia, C. P. and Yuan, J. and Yue, Y. and Leuthardt, E. C. and Benzinger, T. L. S. and Nazeri, A. and Chen, H.},
  title   = {{Focused Ultrasound-mediated Liquid Biopsy in a Tauopathy Mouse Model}},
  journal = {Radiology},
  year    = {2023},
  doi     = {10.1148/radiol.220869},
  pmid    = {36719290},
  url     = {https://doi.org/10.1148/radiol.220869}
}

@article{abdelfatah2021-34052296,
  author  = {Abd El-Fatah, I. M. and Abdelrazek, H. M. A. and Ibrahim, S. M. and Abdallah, D. M. and El-Abhar, H. S.},
  title   = {{Dimethyl fumarate abridged tauo-/amyloidopathy in a D-Galactose/ovariectomy-induced Alzheimer's-like disease: Modulation of AMPK/SIRT-1, AKT/CREB/BDNF, AKT/GSK-3β, adiponectin/Adipo1R, and NF-κB/IL-1β/ROS trajectories}},
  journal = {Neurochemistry international},
  year    = {2021},
  doi     = {10.1016/j.neuint.2021.105082},
  pmid    = {34052296},
  url     = {https://doi.org/10.1016/j.neuint.2021.105082}
}

@article{lleo2021-870cda97,
  author  = {Lleó, A. and Carmona-Iragui, M. and Videla, L. and Fernández, S. and Benejam, B. and Pegueroles, J. and Barroeta, I. and Altuna, M. and others},
  title   = {{VAMP-2 Is a Surrogate Cerebrospinal Fluid Marker of Alzheimer-related Cognitive Impairment in Adults With Down Syndrome}},
  journal = {Alzheimer's research \& therapy},
  year    = {2021},
  doi     = {10.21203/rs.3.rs-340117/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-340117/v1}
}

@article{moelgg2021-33804246,
  author  = {Moelgg, K. and Jummun, F. and Humpel, C.},
  title   = {{Spreading of Beta-Amyloid in Organotypic Mouse Brain Slices and Microglial Elimination and Effects on Cholinergic Neurons}},
  journal = {Biomolecules},
  year    = {2021},
  doi     = {10.3390/biom11030434},
  pmid    = {33804246},
  url     = {https://doi.org/10.3390/biom11030434}
}

@article{chen2021-33691783,
  author  = {Chen, X. Q. and Das, U. and Park, G. and Mobley, W. C.},
  title   = {{Normal levels of KIF5 but reduced KLC1 levels in both Alzheimer disease and Alzheimer disease in Down syndrome: evidence suggesting defects in anterograde transport}},
  journal = {Alzheimer's research \& therapy},
  year    = {2021},
  doi     = {10.1186/s13195-021-00796-6},
  pmid    = {33691783},
  url     = {https://doi.org/10.1186/s13195-021-00796-6}
}

@article{davtyan2019-31847886,
  author  = {Davtyan, H. and Hovakimyan, A. and Kiani Shabestari, S. and Antonyan, T. and Coburn, M. A. and Zagorski, K. and Chailyan, G. and Petrushina, I. and others},
  title   = {{Testing a MultiTEP-based combination vaccine to reduce Aβ and tau pathology in Tau22/5xFAD bigenic mice}},
  journal = {Alzheimer's research \& therapy},
  year    = {2019},
  doi     = {10.1186/s13195-019-0556-2},
  pmid    = {31847886},
  url     = {https://doi.org/10.1186/s13195-019-0556-2}
}

@article{zhou2019-31843022,
  author  = {Zhou, L. and Flores, J. and Noël, A. and Beauchet, O. and Sjöström, P. J. and LeBlanc, A. C.},
  title   = {{Methylene blue inhibits Caspase-6 activity, and reverses Caspase-6-induced cognitive impairment and neuroinflammation in aged mice}},
  journal = {Acta neuropathologica communications},
  year    = {2019},
  doi     = {10.1186/s40478-019-0856-6},
  pmid    = {31843022},
  url     = {https://doi.org/10.1186/s40478-019-0856-6}
}

@article{bortolotti2019-31831060,
  author  = {Bortolotti, D. and Gentili, V. and Rotola, A. and Caselli, E. and Rizzo, R.},
  title   = {{HHV-6A infection induces amyloid-beta expression and activation of microglial cells}},
  journal = {Alzheimer's research \& therapy},
  year    = {2019},
  doi     = {10.1186/s13195-019-0552-6},
  pmid    = {31831060},
  url     = {https://doi.org/10.1186/s13195-019-0552-6}
}

@article{xue2020-31836271,
  author  = {Xue, D. and Tabib, T. and Morse, C. and Lafyatis, R.},
  title   = {{Transcriptome landscape of myeloid cells in human skin reveals diversity, rare populations and putative DC progenitors}},
  journal = {Journal of dermatological science},
  year    = {2020},
  doi     = {10.1016/j.jdermsci.2019.11.012},
  pmid    = {31836271},
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@article{gao2019-31301160,
  author  = {Gao, T. and Jernigan, J. and Raza, S. A. and Dammer, E. B. and Xiao, H. and Seyfried, N. T. and Levey, A. I. and Rangaraju, S.},
  title   = {{Transcriptional regulation of homeostatic and disease-associated-microglial genes by IRF1, LXRβ, and CEBPα}},
  journal = {Glia},
  year    = {2019},
  doi     = {10.1002/glia.23678},
  pmid    = {31301160},
  url     = {https://doi.org/10.1002/glia.23678}
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@article{liu2019-30684126,
  author  = {Liu, A. H. and Chu, M. and Wang, Y. P.},
  title   = {{Up-Regulation of Trem2 Inhibits Hippocampal Neuronal Apoptosis and Alleviates Oxidative Stress in Epilepsy via the PI3K/Akt Pathway in Mice}},
  journal = {Neuroscience bulletin},
  year    = {2019},
  doi     = {10.1007/s12264-018-0324-5},
  pmid    = {30684126},
  url     = {https://doi.org/10.1007/s12264-018-0324-5}
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@article{zhang2018-30318466,
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  title   = {{Structural Basis for Recognition of a Unique Epitope by a Human Anti-tau Antibody}},
  journal = {Structure (London, England : 1993)},
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  title   = {{Distinct and combined interferon-ɑ/β-receptor-1 loss in neurons and astrocytes disrupt brain energy metabolism and drive Parkinsonian dementia}},
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@article{grobner2026-42143322,
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@article{wang2026-42187024,
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  title   = {{Systemic delivery of synapsin‐promoted caveolin‐1 overexpression ameliorates pathological TDP‐43–induced cognitive decline and neurodegenerative changes}},
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  year    = {2026},
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@article{viola2026-41925203,
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  title   = {{Cinnamon Bud Extract Is a Source of Biomolecules Active against the Aggregation and Condensation of Alzheimer′s-Associated Tau Protein}},
  journal = {Journal of Agricultural and Food Chemistry},
  year    = {2026},
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@article{zainurin2026-41927515,
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  title   = {{Microglial reactivity predicts hippocampal, but not global, atrophy in cerebral small vessel disease}},
  journal = {Alzheimer s \& Dementia},
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}

@article{royse2026-41919494,
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  title   = {{Synaptic loss in alcohol use disorder: clinical and mechanistic insights from a PET imaging study}},
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  year    = {2026},
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}

@article{ryan2026-41982423,
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  title   = {{Clinicopathological features of primary tauopathies: a brain bank series}},
  journal = {Frontiers in Neurology},
  year    = {2026},
  doi     = {10.3389/fneur.2026.1768959},
  pmid    = {41982423},
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}

@article{puech2026-41630648,
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  title   = {{APP‐mediated intracellular signaling rescues sleep impairment and blood–brain barrier leakage in Alzheimer's disease mouse model}},
  journal = {Alzheimer s \& Dementia},
  year    = {2026},
  doi     = {10.1002/alz.71134},
  pmid    = {41630648},
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}

@article{purvinsh2026-41609580,
  author  = {Purvinsh, Yana and Matveyenka, Mikhail and Kurouski, Dmitry},
  title   = {{Elucidation of Molecular Mechanisms of Lipid-Altered Cytotoxicity of TDP-43 Fibrils}},
  journal = {ACS Chemical Neuroscience},
  year    = {2026},
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  pmid    = {41609580},
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}

@article{bosch2026-41695615,
  author  = {Bosch, Megan E. and Ulrich, Jason D.},
  title   = {{Spilling the T: T cells in tauopathy mechanisms, disease progression, and therapeutic horizons}},
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  year    = {2026},
  doi     = {10.1186/s44477-026-00020-5},
  pmid    = {41695615},
  url     = {https://doi.org/10.1186/s44477-026-00020-5}
}

@article{halbgebauer2026-a544b959,
  author  = {Halbgebauer, Rebecca and Otto, Markus and weitere], [und viele},
  title   = {{Blood-based analysis of different tau variants in patients with multiple traumatic injuries}},
  journal = {Digitalen Hochschulbibliothek Sachsen-Anhalt (Universitäts- und Landesbibliothek Sachsen-Anhalt)},
  year    = {2026},
  doi     = {10.25673/123000},
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}

@article{shenouda2026-41549027,
  author  = {Shenouda, Marc and Shenouda, Sandra and Kartono, Bryan and Eid, Shehab and Cheng, Cheryl and Robertson, Janice},
  title   = {{Small molecule JRMS modulating importin-β1 chaperone activity as a therapeutic strategy reducing TDP-43 pathology}},
  journal = {Neurotherapeutics},
  year    = {2026},
  doi     = {10.1016/j.neurot.2026.e00834},
  pmid    = {41549027},
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}

@article{toledo2025-41434679,
  author  = {Toledo, Lauren and Besser, Lilah M. and Le, Elaine H. and Joshi, Mahesh S. and Galvin, James E},
  title   = {{Associations between systemic inflammation, neighborhood tree canopy, and white matter hyperintensities: The Healthy Brain Initiative}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70860_104126},
  pmid    = {41434679},
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}

@article{morcillonieto2025-89e62d72,
  author  = {Morcillo-Nieto, Alejandra Omaira and Arriola‐Infante, José Enrique and Franquesa‐Mullerat, María and Zsadanyi, Sára E. and Vaqué‐Alcázar, Lídia and Aranha, Mateus Rozalem and Parra, Jose Allende and Zhao, Zili and others},
  title   = {{Early Detection of White Matter Integrity Changes in Down Syndrome: The Promise of PSMD as a Sensitive Biomarker}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70856_106537},
  url     = {https://doi.org/10.1002/alz70856_106537}
}

@article{vanbrabant2025-41518608,
  author  = {Vanbrabant, Jeroen and Van Loo, Maxime and Blancke, Nathan and Antwi‐Berko, Daniel and van der Flier, Wiesje M. and Verberk, Inge M.W. and Teunissen, Charlotte Elisabeth and Stoops, Erik},
  title   = {{Analytical Qualification of the BD‐Tau Xplorer kit on LUMIPULSE® G1200}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
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  pmid    = {41518608},
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}

@article{zhang2025-41291718,
  author  = {Zhang, Minjie and You, Tongyao and Guo, Min and Zhao, Yichen and Shen, Weiwei and Jiang, Yanfeng and others},
  title   = {{Activated microglial exosomes enhance α-Synuclein internalization and accelerate neurodegeneration in lewy body dementia}},
  journal = {Journal of Nanobiotechnology},
  year    = {2025},
  doi     = {10.1186/s12951-025-03838-5},
  pmid    = {41291718},
  url     = {https://doi.org/10.1186/s12951-025-03838-5}
}

@article{min2025-41300248,
  author  = {Min, Young and Lee, Yoon-Seob and Lee, Juwon and Keum, Da-Young and Gwag, Joo-Young and Jeon, Soyeon and Jo, Heejin and Kang, Sung-Ung},
  title   = {{The cGAS–STING Pathway in Dementia: An Emerging Mechanism of Neuroinflammation}},
  journal = {Brain Sciences},
  year    = {2025},
  doi     = {10.3390/brainsci15111241},
  pmid    = {41300248},
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}

@article{gbadamosi2025-41303511,
  author  = {Gbadamosi, Monsurat T. and Romano, Giulia and Simbula, Michela and Canarutto, Giulia and Ottoboni, Linda K. and Corti, Stefania Paola and Feiguin, Fabian M.},
  title   = {{TDP-43 Regulates Rab4 Levels to Support Synaptic Vesicle Recycling and Neuromuscular Connectivity in Drosophila and Human ALS Models}},
  journal = {International Journal of Molecular Sciences},
  year    = {2025},
  doi     = {10.3390/ijms262211030},
  pmid    = {41303511},
  url     = {https://doi.org/10.3390/ijms262211030}
}

@article{liu2025-41199342,
  author  = {Liu, Yue and Sobue, Akira and Sahara, Naruhiko and Isobe, Madoka and Tanaka, Rinako and Zhu, Youyun and Zhu, Wenjun and Matsuzaki, Tetsuo and others},
  title   = {{Abnormal behaviors and glial responses in an animal model of tau pathology}},
  journal = {Molecular Brain},
  year    = {2025},
  doi     = {10.1186/s13041-025-01252-4},
  pmid    = {41199342},
  url     = {https://doi.org/10.1186/s13041-025-01252-4}
}

@article{nasb2025-81f12896,
  author  = {Nasb, Mohammad and Dayoub, Lamis and Chen, Ning},
  title   = {{Precision prevention in exercise: Integrating OMICS biomarkers and artificial intelligence for injury risk assessment}},
  journal = {Advanced Exercise and Health Science},
  year    = {2025},
  doi     = {10.1016/j.aehs.2025.09.001},
  url     = {https://doi.org/10.1016/j.aehs.2025.09.001}
}

@article{heavener2025-40987420,
  author  = {Heavener, Kelsey S. and Tamucci, Kirstin A. and Lee, Annie and Kabra, Khushbu and Chatila, Zena K. and Yidenk, Maedot and Bennett, David and Vardarajan, Badri Narayan and others},
  title   = {{P2RX7 modulates the function of human microglia-like cells and mediates the association of IL18 with Alzheimer's disease traits}},
  journal = {Neurobiology of Disease},
  year    = {2025},
  doi     = {10.1016/j.nbd.2025.107106},
  pmid    = {40987420},
  url     = {https://doi.org/10.1016/j.nbd.2025.107106}
}

@article{rivera2025-01964e62,
  author  = {Rivera, Sofía Lucila Rodríguez and Martínez, Héctor R. and Cantú, José Antonio Infante and Osorio, Enrique Caro},
  title   = {{Exploring the relationship between epilepsy and neurodegenerative diseases}},
  journal = {Romanian Journal of Neurology},
  year    = {2025},
  doi     = {10.37897/rjn.2025.3.2},
  url     = {https://doi.org/10.37897/rjn.2025.3.2}
}

@article{lee2025-40702818,
  author  = {Lee, Tsz‐lok and Kwok, Timothy C. Y. and LINDA C. W., L. A. M. and Fung, Helene Hoi-Lam and Cheung, Mei‐chun and Han, Yvonne M. Y. and Chan, Agnes Sui-Yin},
  title   = {{Improved cognitive function, efficiency, saccadic eye movement, and depressive symptoms in mild cognitive impairment with transcranial photobiomodulation}},
  journal = {Journal of Alzheimer s Disease},
  year    = {2025},
  doi     = {10.1177/13872877251361033},
  pmid    = {40702818},
  url     = {https://doi.org/10.1177/13872877251361033}
}

@article{atwal2025-40772263,
  author  = {Atwal, Manpreet Singh and Nimac, Jerneja and Čerček, Urša and Goesch, Sarah Ricarda and Goesch, Hannah Rebecca and Tziortzouda, Paraskevi and Ercolani, Tiziana and Zatorska, Anna and others},
  title   = {{Accumulation of TDP-43 causes karyopherin-α4 pathology that characterises amyotrophic lateral sclerosis}},
  journal = {Frontiers in Neuroscience},
  year    = {2025},
  doi     = {10.3389/fnins.2025.1558227},
  pmid    = {40772263},
  url     = {https://doi.org/10.3389/fnins.2025.1558227}
}

@article{diedrich2025-40653428,
  author  = {Diedrich, Lukas and Izhak, Shachar Ben and Kolhoff, Hannah I. and Bergmann, Clara and Chakalov, Ivan and Bähr, Mathias and Lavidor, Michal and Antal, Andrea},
  title   = {{No robust add-on effects of prefrontal theta–gamma tACS to cognitive training on episodic memory in non-demented older adults}},
  journal = {Clinical Neurophysiology},
  year    = {2025},
  doi     = {10.1016/j.clinph.2025.2110808},
  pmid    = {40653428},
  url     = {https://doi.org/10.1016/j.clinph.2025.2110808}
}

@article{jann2025-40799842,
  author  = {Jann, Kay and Park, Gilsoon and Ringman, John Matthew and Kim, Hosung},
  title   = {{Classifying mild cognitive impairment from normal cognition: fMRI complexity matches tau PET performance}},
  journal = {Alzheimer s \& Dementia Diagnosis Assessment \& Disease Monitoring},
  year    = {2025},
  doi     = {10.1002/dad2.70159},
  pmid    = {40799842},
  url     = {https://doi.org/10.1002/dad2.70159}
}

@article{zhang2025-40537012,
  author  = {Zhang, Meiyan and Lan, Xiaoyan and Gao, Yue and Li, Shen and Qiao, Guanda and Liang, Yajie and Janowski, Mirosław and Walczak, Piotr and others},
  title   = {{MCC950 suppresses NLRP3-dependent neuroinflammation and ameliorates cognitive decline in a rat model of cerebral small vessel disease}},
  journal = {Neural Regeneration Research},
  year    = {2025},
  doi     = {10.4103/nrr.nrr-d-24-01055},
  pmid    = {40537012},
  url     = {https://doi.org/10.4103/nrr.nrr-d-24-01055}
}

@article{kochen2025-40493571,
  author  = {Kochen, Noah Nathan and Murray, Marguerite and Zafari, Sophia and Vunnam, Nagamani and Liao, Elly E. and Chen, Lihsia and Braun, Anthony R. and Sachs, Jonathan N.},
  title   = {{Fluorescence Lifetime-Based FRET Biosensors for Monitoring N Terminal Domain-Dependent Interactions of TDP-43 in Living Cells: A Novel Approach for ALS and FTD Drug Discovery}},
  journal = {ACS Chemical Neuroscience},
  year    = {2025},
  doi     = {10.1021/acschemneuro.5c00266},
  pmid    = {40493571},
  url     = {https://doi.org/10.1021/acschemneuro.5c00266}
}

@article{bergh2025-40426231,
  author  = {Bergh, Sofia and Casadei, Nicolas and Gabery, Sanaz and Simonsson, Oskar and Duarte, João M. N. and Kirik, Deniz and Nguyen, Huu Phuc and Petersén, Åsa},
  title   = {{TDP-43 overexpression in the hypothalamus drives neuropathology, dysregulates metabolism and impairs behavior in mice}},
  journal = {Acta Neuropathologica Communications},
  year    = {2025},
  doi     = {10.1186/s40478-025-02018-8},
  pmid    = {40426231},
  url     = {https://doi.org/10.1186/s40478-025-02018-8}
}

@article{kraller2025-40405265,
  author  = {Kraller, Markus and Faßbender, Julia and Jabali, Ammar and Kroeger, Joseph A. and Fink, Barbara and Popper, Bastian and Ungerer, Martin and Christlmeier, Miriam A.},
  title   = {{Novel fully human high-affinity anti-TREM2 antibody shows efficacy in clinically relevant Alzheimer´s mouse model}},
  journal = {Alzheimer s Research \& Therapy},
  year    = {2025},
  doi     = {10.1186/s13195-025-01759-x},
  pmid    = {40405265},
  url     = {https://doi.org/10.1186/s13195-025-01759-x}
}

@article{arandaabreu2025-40423231,
  author  = {Aranda-Abreu, Gonzálo Emiliano and Rojas-Durán, Fausto and Hernández‐Aguilar, María Elena and Herrera‐Covarrubias, Deissy and García, Luis I. and Toledo‐Cárdenas, María Rebeca and Chi-Castañeda, Donají},
  title   = {{The Role of Tau in Neuronal Function and Neurodegeneration}},
  journal = {Neurology International},
  year    = {2025},
  doi     = {10.3390/neurolint17050075},
  pmid    = {40423231},
  url     = {https://doi.org/10.3390/neurolint17050075}
}

@article{lu2025-40326096,
  author  = {Lu, Yujia and Cheng, Lin and Xiong, Yinyi and Huang, Chunyan and Liu, Ziying and Shen, Chunxiao and Wang, Huaying and Qiu, Yuemin and others},
  title   = {{NLRP3 Inflammasome in Vascular Dementia: Regulatory Mechanisms, Functions, and Therapeutic Implications: A Comprehensive Review}},
  journal = {CNS Neuroscience \& Therapeutics},
  year    = {2025},
  doi     = {10.1111/cns.70403},
  pmid    = {40326096},
  url     = {https://doi.org/10.1111/cns.70403}
}

@article{kim2025-40358180,
  author  = {Kim, Eun‐Young and Hong, Ki-Sung and Lee, Dong-Hun and Lee, Eun Chae and Chung, Hyung-Min and Park, Se‐Pill and Lee, Man Ryul and Oh, Jae Sang},
  title   = {{Multipotent Mesenchymal Stem Cell Therapy for Vascular Dementia}},
  journal = {Cells},
  year    = {2025},
  doi     = {10.3390/cells14090651},
  pmid    = {40358180},
  url     = {https://doi.org/10.3390/cells14090651}
}

@article{litus2025-50e87e79,
  author  = {Litus, E. A. and Shevelyova, M. P. and Vologzhannikova, A. A. and Deryusheva, E. I. and Chaplygina, A. V. and Rastrygina, V. A. and Machulin, A. V. and Alikova, V. D. and others},
  title   = {{Interaction of Glucagon-Like Peptide 1 and Its Analogues with Amyloid-β Peptide Affects Its Fibrillation and Cytotoxicity}},
  journal = {International journal of molecular sciences},
  year    = {2025},
  doi     = {10.20944/preprints202504.2038.v1},
  url     = {https://doi.org/10.20944/preprints202504.2038.v1}
}

@article{richter2025-40116674,
  author  = {Richter, Nils and Breidenbach, Laura and Schmieschek, Maximilian H.T. and Heiss, Wolf‐Dieter and Fink, Gereon R. and Onur, Oezguer A.},
  title   = {{Alzheimer-typical temporo-parietal atrophy and hypoperfusion are associated with a more significant cholinergic impairment in amnestic neurodegenerative syndromes}},
  journal = {Journal of Alzheimer s Disease},
  year    = {2025},
  doi     = {10.1177/13872877251324080},
  pmid    = {40116674},
  url     = {https://doi.org/10.1177/13872877251324080}
}

@article{ordonez2025-40056267,
  author  = {Ordoñez, Willian Orlando Castillo and Palomino, Nilza Velasco and Varela, Patricia Eugenia Vélez and Martinez, Indeara and Alves, Levy Bueno and Giuliatti, Silvana},
  title   = {{Alkaloids from Caliphruria subedentata (Amaryllidaceae) as Regulators of AChE, BuChE, NMDA and GSK3 Activity: An In Vitro and In Silico Approach for Mimicking Alzheimer´s Disease}},
  journal = {Neurochemical Research},
  year    = {2025},
  doi     = {10.1007/s11064-025-04354-6},
  pmid    = {40056267},
  url     = {https://doi.org/10.1007/s11064-025-04354-6}
}

@article{gonzalez2025-40063372,
  author  = {Gonzalez, Amanda Inez and Edwards, Lauren C. and Thomas, Kelsey R. and Weigand, Alexandra J. and Bordyug, Maria and Brenner, Einat K. and Urias, Uriel A. and Bangen, Katherine J.},
  title   = {{Growth-associated protein 43 is associated with faster functional decline among amyloid-positive individuals with objectively defined subtle cognitive decline and mild cognitive impairment}},
  journal = {Neuropsychology},
  year    = {2025},
  doi     = {10.1037/neu0000981},
  pmid    = {40063372},
  url     = {https://doi.org/10.1037/neu0000981}
}

@article{citu2025-40124487,
  author  = {Citu, Citu and Chang, Le and Manuel, Astrid Marilyn and Enduru, Nitesh and Zhao, Zhongming},
  title   = {{Identification and catalog of viral transcriptional regulators in human diseases}},
  journal = {iScience},
  year    = {2025},
  doi     = {10.1016/j.isci.2025.112081},
  pmid    = {40124487},
  url     = {https://doi.org/10.1016/j.isci.2025.112081}
}

@article{nadtochy2025-40149527,
  author  = {Nadtochy, Julia A. and Medvedev, Sergey P. and Grigor’eva, Elena V. and Pavlova, Sophia V. and Minina, Julia M. and Chechushkov, Anton V. and Malakhova, Anastasia A. and Коваленко, Л. В. and others},
  title   = {{Transgenic iPSC Lines with Genetically Encoded MitoTimer to Study Mitochondrial Biogenesis in Dopaminergic Neurons with Tauopathy}},
  journal = {Biomedicines},
  year    = {2025},
  doi     = {10.3390/biomedicines13030550},
  pmid    = {40149527},
  url     = {https://doi.org/10.3390/biomedicines13030550}
}

@article{yuan2025-40013095,
  author  = {Yuan, Ziyi and Huang, Zhaodi and Li, Chaojun and Li, Shengrong and Ren, Qingguo and Xia, Xiaona and Jiang, Qingjun and Zhang, Daoqiang and others},
  title   = {{Multimodal fusion model for diagnosing mild cognitive impairment in unilateral middle cerebral artery steno-occlusive disease}},
  journal = {Frontiers in Aging Neuroscience},
  year    = {2025},
  doi     = {10.3389/fnagi.2025.1527323},
  pmid    = {40013095},
  url     = {https://doi.org/10.3389/fnagi.2025.1527323}
}

@article{carbonell2025-39989007,
  author  = {Carbonell, Félix and McNicoll, Carolann and Zijdenbos, Alex P. and Bedell, Barry J. and {Alzheimer's Disease Neuroimaging Initiative}},
  title   = {{Tau‐related reduction of glucose metabolism in mild cognitive impairment occurs independently of APOE ε4 genotype and is influenced by Aβ}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz.14625},
  pmid    = {39989007},
  url     = {https://doi.org/10.1002/alz.14625}
}

@article{silvallanes2025-39931431,
  author  = {Silva-Llanes, Ignacio and Madruga, Enrique López and Martı́nez, Ana and Lastres‐Becker, Isabel},
  title   = {{RIPK1 expression and inhibition in tauopathies: implications for neuroinflammation and neuroprotection}},
  journal = {Frontiers in Neuroscience},
  year    = {2025},
  doi     = {10.3389/fnins.2024.1530809},
  pmid    = {39931431},
  url     = {https://doi.org/10.3389/fnins.2024.1530809}
}

@article{wang2025-39911382,
  author  = {Wang, Xiaohang and Wang, Qianqian and Cai, Zhensheng and Ni, Chengming and Wang, Huan and Liu, Hui and Zhao, Yusong and Wang, Jinbang and others},
  title   = {{Knockdown of PDPN in astrocytes reduces hippocampal inflammation in T2DM mice}},
  journal = {Frontiers in Immunology},
  year    = {2025},
  doi     = {10.3389/fimmu.2025.1503807},
  pmid    = {39911382},
  url     = {https://doi.org/10.3389/fimmu.2025.1503807}
}

@article{liu2025-39794619,
  author  = {Liu, Qianshuo and Jiang, Meixi and Wang, Zening and Meng, Jihong and Jia, Hui and Li, Jing and Lin, Jing‐Jer and Guo, Libin and others},
  title   = {{SENP1 inhibits aerobic glycolysis in Aβ1-42-incubated astrocytes by promoting PUM2 deSUMOylation}},
  journal = {Cell Biology and Toxicology},
  year    = {2025},
  doi     = {10.1007/s10565-025-09986-6},
  pmid    = {39794619},
  url     = {https://doi.org/10.1007/s10565-025-09986-6}
}

@article{lana2025-39835288,
  author  = {Lana, Daniele and Ugolini, Filippo and Iovino, Ludovica and Attorre, Selene and Giovannini, Maria Grazia},
  title   = {{Astrocytes phenomics as new druggable targets in healthy aging and Alzheimer’s disease progression}},
  journal = {Frontiers in Cellular Neuroscience},
  year    = {2025},
  doi     = {10.3389/fncel.2024.1512985},
  pmid    = {39835288},
  url     = {https://doi.org/10.3389/fncel.2024.1512985}
}

@article{cidfernandez2025-40237781,
  author  = {Cid‐Fernández, Susana and Nieto‐Vieites, Ana and Pereiro, Arturo X. and Dı́az, Fernando},
  title   = {{Transcranial Alternating Current Stimulation and Cognitive Training Enhanced Performance and Theta Activity in Adults With Cognitive Impairment}},
  journal = {Psicothema},
  year    = {2025},
  doi     = {10.70478/psicothema.2025.37.11},
  pmid    = {40237781},
  url     = {https://doi.org/10.70478/psicothema.2025.37.11}
}

@article{fan2024-0f42f421,
  author  = {Fan, Erica and Royse, Sarah K. and Reese, Alexandria C. and Karikari, Thomas K. and Pascoal, Tharick Ali and Shaaban, C. Elizabeth and Villemagne, Victor L. and Cohen, Ann D.},
  title   = {{NEIGHBORHOOD DISADVANTAGE AND THE ASSOCIATION OF PLASMA BIOMARKERS WITH COGNITION IN A COHORT OF DIVERSE ADULTS}},
  journal = {Innovation in Aging},
  year    = {2024},
  doi     = {10.1093/geroni/igae098.1504},
  url     = {https://doi.org/10.1093/geroni/igae098.1504}
}

@article{zou2024-39545066,
  author  = {Zou, Y. and Wang, C. and Li, H. and Zhong, M. and Lin, J. and Hu, Y. and Chen, Z. and Gan, C. L.},
  title   = {{Epileptic seizures induced by pentylenetetrazole kindling accelerate Alzheimer-like neuropathology in 5×FAD mice}},
  journal = {Frontiers in pharmacology},
  year    = {2024},
  doi     = {10.3389/fphar.2024.1500105},
  pmid    = {39545066},
  url     = {https://doi.org/10.3389/fphar.2024.1500105}
}

@article{schuy2024-39669604,
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  title   = {{A combination of long- and short-read genomics reveals frequent p-arm breakpoints within chromosome 21 complex genomic rearrangements}},
  journal = {Genetics in medicine open},
  year    = {2024},
  doi     = {10.1016/j.gimo.2024.101863},
  pmid    = {39669604},
  url     = {https://doi.org/10.1016/j.gimo.2024.101863}
}

@article{ali2024-36567300,
  author  = {Ali, M. U. and Anwar, L. and Ali, M. H. and Iqubal, M. K. and Iqubal, A. and Baboota, S. and Ali, J.},
  title   = {{Signalling Pathways Involved in Microglial Activation in Alzheimer's Disease and Potential Neuroprotective Role of Phytoconstituents}},
  journal = {CNS \& neurological disorders drug targets},
  year    = {2024},
  doi     = {10.2174/1871527322666221223091529},
  pmid    = {36567300},
  url     = {https://doi.org/10.2174/1871527322666221223091529}
}

@article{xiong2022-35704147,
  author  = {Xiong, J. and Deng, I. and Kelliny, S. and Lin, L. and Bobrovskaya, L. and Zhou, X. F.},
  title   = {{Long term high fat diet induces metabolic disorders and aggravates behavioral disorders and cognitive deficits in MAPT P301L transgenic mice}},
  journal = {Metabolic brain disease},
  year    = {2022},
  doi     = {10.1007/s11011-022-01029-x},
  pmid    = {35704147},
  url     = {https://doi.org/10.1007/s11011-022-01029-x}
}

@article{powell2021-bcef8f4e,
  author  = {Powell, W. Ryan and Zuelsdorff, Megan L. and Chin, Nathaniel A. and Buckingham, William R. and Rissman, Robert A. and Bendlin, Barbara B. and Kind, Amy},
  title   = {{Geographic proximity, neuropathology and ADRC brain donation}},
  journal = {Alzheimer s \& Dementia},
  year    = {2021},
  doi     = {10.1002/alz.057512},
  url     = {https://doi.org/10.1002/alz.057512}
}

@article{lemoine2020-33222700,
  author  = {Lemoine, L. and Ledreux, A. and Mufson, E. J. and Perez, S. E. and Simic, G. and Doran, E. and Lott, I. and Carroll, S. and others},
  title   = {{Regional binding of tau and amyloid PET tracers in Down syndrome autopsy brain tissue}},
  journal = {Molecular neurodegeneration},
  year    = {2020},
  doi     = {10.1186/s13024-020-00414-3},
  pmid    = {33222700},
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@article{lowry2020-33161065,
  author  = {Lowry, JR. and Marshall, N. and Wenzel, T. J. and Murray, T. E. and Klegeris, A.},
  title   = {{The dietary fatty acids α-linolenic acid (ALA) and linoleic acid (LA) selectively inhibit microglial nitric oxide production}},
  journal = {Molecular and cellular neurosciences},
  year    = {2020},
  doi     = {10.1016/j.mcn.2020.103569},
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@article{martinezcue2020-32962300,
  author  = {Martínez-Cué, C. and Rueda, N.},
  title   = {{Signalling Pathways Implicated in Alzheimer's Disease Neurodegeneration in Individuals with and without Down Syndrome}},
  journal = {International journal of molecular sciences},
  year    = {2020},
  doi     = {10.3390/ijms21186906},
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}

@article{massaccesi2020-32814082,
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  title   = {{Erythrocytes as markers of oxidative stress related pathologies}},
  journal = {Mechanisms of ageing and development},
  year    = {2020},
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  pmid    = {32814082},
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@article{santisteban2020-32654560,
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  title   = {{Endothelium-Macrophage Crosstalk Mediates Blood-Brain Barrier Dysfunction in Hypertension}},
  journal = {Hypertension (Dallas, Tex. : 1979)},
  year    = {2020},
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  pmid    = {32654560},
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}

@article{schwarz2020-32629145,
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  title   = {{Spermidine intake is associated with cortical thickness and hippocampal volume in older adults}},
  journal = {NeuroImage},
  year    = {2020},
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  pmid    = {32629145},
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@article{riad2020-32572762,
  author  = {Riad, A. and Lengyel-Zhand, Z. and Zeng, C. and Weng, C. C. and Lee, V. M. and Trojanowski, J. Q. and Mach, R. H.},
  title   = {{The Sigma-2 Receptor/TMEM97, PGRMC1, and LDL Receptor Complex Are Responsible for the Cellular Uptake of Aβ42 and Its Protein Aggregates}},
  journal = {Molecular neurobiology},
  year    = {2020},
  doi     = {10.1007/s12035-020-01988-1},
  pmid    = {32572762},
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}

@article{wang2020-32493725,
  author  = {Wang, X. and Li, W. and Marcus, J. and Pearson, M. and Song, L. and Smith, K. and Terracina, G. and Lee, J. and others},
  title   = {{MK-8719, a Novel and Selective O-GlcNAcase Inhibitor That Reduces the Formation of Pathological Tau and Ameliorates Neurodegeneration in a Mouse Model of Tauopathy}},
  journal = {The Journal of pharmacology and experimental therapeutics},
  year    = {2020},
  doi     = {10.1124/jpet.120.266122},
  pmid    = {32493725},
  url     = {https://doi.org/10.1124/jpet.120.266122}
}

@article{cervellati2020-32143546,
  author  = {Cervellati, C. and Trentini, A. and Pecorelli, A. and Valacchi, G.},
  title   = {{Inflammation in Neurological Disorders: The Thin Boundary Between Brain and Periphery}},
  journal = {Antioxidants \& redox signaling},
  year    = {2020},
  doi     = {10.1089/ars.2020.8076},
  pmid    = {32143546},
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}

@article{zhao2020-32024798,
  author  = {Zhao, N. and Attrebi, O. N. and Ren, Y. and Qiao, W. and Sonustun, B. and Martens, Y. A. and Meneses, A. D. and Li, F. and others},
  title   = {{APOE4 exacerbates α-synuclein pathology and related toxicity independent of amyloid}},
  journal = {Science translational medicine},
  year    = {2020},
  doi     = {10.1126/scitranslmed.aay1809},
  pmid    = {32024798},
  url     = {https://doi.org/10.1126/scitranslmed.aay1809}
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@article{henderson2020-31899072,
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  title   = {{Glucocerebrosidase Activity Modulates Neuronal Susceptibility to Pathological α-Synuclein Insult}},
  journal = {Neuron},
  year    = {2020},
  doi     = {10.1016/j.neuron.2019.12.004},
  pmid    = {31899072},
  url     = {https://doi.org/10.1016/j.neuron.2019.12.004}
}

@article{niaki2020-31630970,
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  title   = {{Loss of Dynamic RNA Interaction and Aberrant Phase Separation Induced by Two Distinct Types of ALS/FTD-Linked FUS Mutations}},
  journal = {Molecular cell},
  year    = {2020},
  doi     = {10.1016/j.molcel.2019.09.022},
  pmid    = {31630970},
  url     = {https://doi.org/10.1016/j.molcel.2019.09.022}
}

@article{lauterborn2020-31410926,
  author  = {Lauterborn, J. C. and Cox, C. D. and Chan, S. W. and Vanderklish, P. W. and Lynch, G. and Gall, C. M.},
  title   = {{Synaptic actin stabilization protein loss in Down syndrome and Alzheimer disease}},
  journal = {Brain pathology (Zurich, Switzerland)},
  year    = {2020},
  doi     = {10.1111/bpa.12779},
  pmid    = {31410926},
  url     = {https://doi.org/10.1111/bpa.12779}
}

@article{allen2019-31484829,
  author  = {Allen, M. D. and Springer, D. A. and Burg, M. B. and Boehm, M. and Dmitrieva, N. I.},
  title   = {{Suboptimal hydration remodels metabolism, promotes degenerative diseases, and shortens life}},
  journal = {JCI insight},
  year    = {2019},
  doi     = {10.1172/jci.insight.130949},
  pmid    = {31484829},
  url     = {https://doi.org/10.1172/jci.insight.130949}
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@article{hernandez2019-30918111,
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  title   = {{A farnesyltransferase inhibitor activates lysosomes and reduces tau pathology in mice with tauopathy}},
  journal = {Science translational medicine},
  year    = {2019},
  doi     = {10.1126/scitranslmed.aat3005},
  pmid    = {30918111},
  url     = {https://doi.org/10.1126/scitranslmed.aat3005}
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@article{signaevsky2019-30770886,
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  title   = {{Artificial intelligence in neuropathology: deep learning-based assessment of tauopathy}},
  journal = {Laboratory investigation; a journal of technical methods and pathology},
  year    = {2019},
  doi     = {10.1038/s41374-019-0202-4},
  pmid    = {30770886},
  url     = {https://doi.org/10.1038/s41374-019-0202-4}
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@article{brown2018-29726891,
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  title   = {{Understanding the role of the perivascular space in cerebral small vessel disease}},
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  year    = {2018},
  doi     = {10.1093/cvr/cvy113},
  pmid    = {29726891},
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@article{tapias2018-29860433,
  author  = {Tapias, V. and Jainuddin, S. and Ahuja, M. and Stack, C. and Elipenahli, C. and Vignisse, J. and Gerges, M. and Starkova, N. and others},
  title   = {{Benfotiamine treatment activates the Nrf2/ARE pathway and is neuroprotective in a transgenic mouse model of tauopathy}},
  journal = {Human molecular genetics},
  year    = {2018},
  doi     = {10.1093/hmg/ddy201},
  pmid    = {29860433},
  url     = {https://doi.org/10.1093/hmg/ddy201}
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@article{kim2018-29988049,
  author  = {Kim, D. and Yoo, J. M. and Hwang, H. and Lee, J. and Lee, S. H. and Yun, S. P. and Park, M. J. and Lee, M. and others},
  title   = {{Graphene quantum dots prevent α-synucleinopathy in Parkinson's disease}},
  journal = {Nature nanotechnology},
  year    = {2018},
  doi     = {10.1038/s41565-018-0179-y},
  pmid    = {29988049},
  url     = {https://doi.org/10.1038/s41565-018-0179-y}
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@article{rajani2018-29973407,
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  title   = {{Reversal of endothelial dysfunction reduces white matter vulnerability in cerebral small vessel disease in rats}},
  journal = {Science translational medicine},
  year    = {2018},
  doi     = {10.1126/scitranslmed.aam9507},
  pmid    = {29973407},
  url     = {https://doi.org/10.1126/scitranslmed.aam9507}
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@article{palma2018-29508455,
  author  = {Palma, J. A. and Kaufmann, H.},
  title   = {{Treatment of autonomic dysfunction in Parkinson disease and other synucleinopathies}},
  journal = {Movement disorders : official journal of the Movement Disorder Society},
  year    = {2018},
  doi     = {10.1002/mds.27344},
  pmid    = {29508455},
  url     = {https://doi.org/10.1002/mds.27344}
}

@article{arrant2018-29378861,
  author  = {Arrant, A. E. and Onyilo, V. C. and Unger, D. E. and Roberson, E. D.},
  title   = {{Progranulin Gene Therapy Improves Lysosomal Dysfunction and Microglial Pathology Associated with Frontotemporal Dementia and Neuronal Ceroid Lipofuscinosis}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2018},
  doi     = {10.1523/jneurosci.3081-17.2018},
  pmid    = {29378861},
  url     = {https://doi.org/10.1523/jneurosci.3081-17.2018}
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@article{mckee2018-30482357,
  author  = {Mckee, A. C. and Abdolmohammadi, B. and Stein, T. D.},
  title   = {{The neuropathology of chronic traumatic encephalopathy}},
  journal = {Handbook of clinical neurology},
  year    = {2018},
  doi     = {10.1016/b978-0-444-63954-7.00028-8},
  pmid    = {30482357},
  url     = {https://doi.org/10.1016/b978-0-444-63954-7.00028-8}
}

@article{strang2018-29259137,
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  title   = {{Distinct differences in prion-like seeding and aggregation between Tau protein variants provide mechanistic insights into tauopathies}},
  journal = {The Journal of biological chemistry},
  year    = {2018},
  doi     = {10.1074/jbc.m117.815357},
  pmid    = {29259137},
  url     = {https://doi.org/10.1074/jbc.m117.815357}
}

@article{boku2018-28926161,
  author  = {Boku, S. and Nakagawa, S. and Toda, H. and Hishimoto, A.},
  title   = {{Neural basis of major depressive disorder: Beyond monoamine hypothesis}},
  journal = {Psychiatry and clinical neurosciences},
  year    = {2018},
  doi     = {10.1111/pcn.12604},
  pmid    = {28926161},
  url     = {https://doi.org/10.1111/pcn.12604}
}

@article{tai2018-29050859,
  author  = {Tai, J. and Liu, W. and Li, Y. and Li, L. and Hölscher, C.},
  title   = {{Neuroprotective effects of a triple GLP-1/GIP/glucagon receptor agonist in the APP/PS1 transgenic mouse model of Alzheimer's disease}},
  journal = {Brain research},
  year    = {2018},
  doi     = {10.1016/j.brainres.2017.10.012},
  pmid    = {29050859},
  url     = {https://doi.org/10.1016/j.brainres.2017.10.012}
}

@article{li2017-28983098,
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  title   = {{Tau-based therapies in neurodegeneration: opportunities and challenges}},
  journal = {Nature reviews. Drug discovery},
  year    = {2017},
  doi     = {10.1038/nrd.2017.155},
  pmid    = {28983098},
  url     = {https://doi.org/10.1038/nrd.2017.155}
}

@article{kim2017-28581123,
  author  = {Kim, J. H. and Ko, P. W. and Lee, H. W. and Jeong, J. Y. and Lee, M. G. and Lee, W. H. and Yu, R. and others},
  title   = {{Astrocyte-derived lipocalin-2 mediates hippocampal damage and cognitive deficits in experimental models of vascular dementia}},
  journal = {Glia},
  year    = {2017},
  doi     = {10.1002/glia.23174},
  pmid    = {28581123},
  url     = {https://doi.org/10.1002/glia.23174}
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@article{sompol2017-28559377,
  author  = {Sompol, P. and Furman, J. L. and Pleiss, M. M. and Kraner, S. D. and Artiushin, I. A. and Batten, SR. and Quintero, J. E. and Simmerman, L. A. and others},
  title   = {{Calcineurin/NFAT Signaling in Activated Astrocytes Drives Network Hyperexcitability in Aβ-Bearing Mice}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2017},
  doi     = {10.1523/jneurosci.0877-17.2017},
  pmid    = {28559377},
  url     = {https://doi.org/10.1523/jneurosci.0877-17.2017}
}

@article{milenkovic2018-28455903,
  author  = {Milenkovic, I. and Jarc, J. and Dassler, E. and Aronica, E. and Iyer, A. and Adle-Biassette, H. and Scharrer, A. and Reischer, T. and others},
  title   = {{The physiological phosphorylation of tau is critically changed in fetal brains of individuals with Down syndrome}},
  journal = {Neuropathology and applied neurobiology},
  year    = {2018},
  doi     = {10.1111/nan.12406},
  pmid    = {28455903},
  url     = {https://doi.org/10.1111/nan.12406}
}

@article{schoenfeld2017-28629541,
  author  = {Schoenfeld, T. J. and McCausland, H. C. and Morris, H. D. and Padmanaban, V. and Cameron, H. A.},
  title   = {{Stress and Loss of Adult Neurogenesis Differentially Reduce Hippocampal Volume}},
  journal = {Biological psychiatry},
  year    = {2017},
  doi     = {10.1016/j.biopsych.2017.05.013},
  pmid    = {28629541},
  url     = {https://doi.org/10.1016/j.biopsych.2017.05.013}
}

@article{smith2017-27940601,
  author  = {Smith, L. M. and Strittmatter, S. M.},
  title   = {{Binding Sites for Amyloid-β Oligomers and Synaptic Toxicity}},
  journal = {Cold Spring Harbor perspectives in medicine},
  year    = {2017},
  doi     = {10.1101/cshperspect.a024075},
  pmid    = {27940601},
  url     = {https://doi.org/10.1101/cshperspect.a024075}
}

@article{ayers2018-28506438,
  author  = {Ayers, J. I. and Giasson, B. I. and Borchelt, D. R.},
  title   = {{Prion-like Spreading in Tauopathies}},
  journal = {Biological psychiatry},
  year    = {2018},
  doi     = {10.1016/j.biopsych.2017.04.003},
  pmid    = {28506438},
  url     = {https://doi.org/10.1016/j.biopsych.2017.04.003}
}

@article{liu2017-28202389,
  author  = {Liu, D. and Tang, H. and Li, X. Y. and Deng, M. F. and Wei, N. and Wang, X. and Zhou, Y. F. and Wang, D. Q. and others},
  title   = {{Targeting the HDAC2/HNF-4A/miR-101b/AMPK Pathway Rescues Tauopathy and Dendritic Abnormalities in Alzheimer's Disease}},
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  url     = {https://doi.org/10.1002/alz.71319}
}

@article{qi2026-41604700,
  author  = {Qi, Zihe and Li, Qianyu and Cao, Juanjuan and Xu, Bufan and Jiang, Fan and Wang, Yanbo and Wu, Di and Li, Guoliang},
  title   = {{Chronic Exposure to Thermally Processed Food-Derived Carbon Polymers Accelerated Neuroinflammation in Alzheimer Disease Mice through Microbe–Gut–Brain Axis}},
  journal = {Journal of Agricultural and Food Chemistry},
  year    = {2026},
  doi     = {10.1021/acs.jafc.5c11423},
  pmid    = {41604700},
  url     = {https://doi.org/10.1021/acs.jafc.5c11423}
}

@article{ibrahim2026-41484454,
  author  = {Ibrahim, Mennatallah and Khalil, Asmaa M. and Attia, Heba and Alseekh, Saleh and Mohamed, Ahmed F. and El-Yamany, Mohammed F.},
  title   = {{Gut Microbiome–Sphingolipid Metabolism–Brain Axis Interactions: Neuroprotective Effects of Amitriptyline as Functional Inhibitor of Acid Sphingomyelinase in a Mouse Model of Tauopathy}},
  journal = {Journal of Neuroimmune Pharmacology},
  year    = {2026},
  doi     = {10.1007/s11481-025-10270-x},
  pmid    = {41484454},
  url     = {https://doi.org/10.1007/s11481-025-10270-x}
}

@article{xie2025-41376284,
  author  = {Xie, Xiao‐Yong and Wang, Lu and Xie, Shi-Qi and Zhou, Gui‐Feng and Wen, Qi‐Xin and Ma, Yuanlin and Zhang, Qi‐Lei and Yan, Xiao‐Xin and others},
  title   = {{Cerebral FURIN deficiency impairs astrocytic lipophagy through ITGAV maturation}},
  journal = {Autophagy},
  year    = {2025},
  doi     = {10.1080/15548627.2025.2601039},
  pmid    = {41376284},
  url     = {https://doi.org/10.1080/15548627.2025.2601039}
}

@article{moore2025-41439341,
  author  = {Moore, Noel C. and Song, Yeunjoo E. and Gulyayev, Alex V. and Miskimen, Kristy L. S. and Laux, Reneé A. and Lynn, Audrey H. and Fuzzell, Sarada L. and Hochstetler, Sherri D. and others},
  title   = {{Investigating the effects of complement loci CFH and ARMS2/HTRA1 on Alzheimer Disease}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70855_106578},
  pmid    = {41439341},
  url     = {https://doi.org/10.1002/alz70855_106578}
}

@article{jayaprakash2025-41433750,
  author  = {Jayaprakash, Theyaneshwaran and Cornelison, Connor Lee and Powla, Plamena P. and Zhang, Lu and Fredericks, Carolyn A. and Saykin, Andrew J. and Wang, Selena},
  title   = {{Deep Learning Framework for Characterizing Tau‐PET Spatial Heterogeneity along AD Spectrum: A Self‐supervised Approach}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70862_109949},
  pmid    = {41433750},
  url     = {https://doi.org/10.1002/alz70862_109949}
}

@article{jayaprakash2025-41442629,
  author  = {Jayaprakash, Theyaneshwaran and Cornelison, Connor Lee and Powla, Plamena P. and Zhang, Lu and Fredericks, Carolyn A. and Saykin, Andrew J. and Wang, Selena},
  title   = {{Deep Learning Framework for Characterizing Tau‐PET Spatial Heterogeneity along AD Spectrum: A Self‐supervised Approach}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70856_102531},
  pmid    = {41442629},
  url     = {https://doi.org/10.1002/alz70856_102531}
}

@article{tuil2025-41447471,
  author  = {Tuil, Marie Emilie and Allehyany, Bshaier and Edison, Paul},
  title   = {{CSF YKL‐40 demonstrates stage‐specific effects of astrocytic reactivity on Alzheimer's Disease pathology}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70856_100751},
  pmid    = {41447471},
  url     = {https://doi.org/10.1002/alz70856_100751}
}

@article{kiran2025-41373431,
  author  = {Kiran, Sonia and Thilanka, Uvindu and Xue, Yu and Sang, Qing‐Xiang Amy},
  title   = {{Polystyrene Micro- and Nanoplastic Exposure Triggers an Activation and Stress Response in Human Astrocytes}},
  journal = {International Journal of Molecular Sciences},
  year    = {2025},
  doi     = {10.3390/ijms262311273},
  pmid    = {41373431},
  url     = {https://doi.org/10.3390/ijms262311273}
}

@article{ray2025-41216864,
  author  = {Ray, Sudipta and Kumar, Mohit and Chemparathy, Divya T. and Dash, Prasanta K. and Sil, Susmita},
  title   = {{HIF‐1 Targeting Intervention Renders Protection From Alzheimer's‐Like Pathology in a Humanized Mice Model of HIV Infection}},
  journal = {Journal of Extracellular Vesicles},
  year    = {2025},
  doi     = {10.1002/jev2.70191},
  pmid    = {41216864},
  url     = {https://doi.org/10.1002/jev2.70191}
}

@article{barbosa2025-41141721,
  author  = {Barbosa, Deyse Brito and de Oliveira, Lucas Matheus Gonçalves and Mendes, Géssica Oliveira and Costa, David Bacelar and de Oliveira, Tiago Alves and da Silva, Michel Pires and Damázio, Laila Cristina Moreira and Maia, Eduardo Habib Bechelane and others},
  title   = {{Silodosin as a Novel Inhibitor of Acetylcholinesterase, Butyrylcholinesterase, and BETA-Secretase 1: In Vitro and In Silico Studies}},
  journal = {ACS Omega},
  year    = {2025},
  doi     = {10.1021/acsomega.5c07084},
  pmid    = {41141721},
  url     = {https://doi.org/10.1021/acsomega.5c07084}
}

@article{peng2025-40898457,
  author  = {Peng, Shijun and Ouyang, Jia and Liu, Yezu and Wang, Lepeng and Liu, Ruen},
  title   = {{Causal effect of infectious mononucleosis on neurodegenerative diseases: A Mendelian randomization study}},
  journal = {Medicine},
  year    = {2025},
  doi     = {10.1097/md.0000000000044145},
  pmid    = {40898457},
  url     = {https://doi.org/10.1097/md.0000000000044145}
}

@article{goud2025-40862394,
  author  = {Goud, Alladi Charanraj and Kozlov, Iu P and Skoupilová, Patricie and Malina, Lukáš and Roy, Sudeep and Das, Viswanath},
  title   = {{Structural and functional insights into the selective inhibition of mutant tau aggregation by purpurin and oleocanthal in frontotemporal dementia}},
  journal = {Protein Science},
  year    = {2025},
  doi     = {10.1002/pro.70240},
  pmid    = {40862394},
  url     = {https://doi.org/10.1002/pro.70240}
}

@article{wu2025-41268317,
  author  = {Wu, Yuying and Zhang, Zhizhen and Lian, Xiao‐Yuan},
  title   = {{Ginsenoside Rc mitigates hippocampal neuronal damage and cognitive impairment in vascular dementia rats via the pY705-Stat3/Foxo3a and pS727-Stat3/GRIM-19 pathways}},
  journal = {Journal of Ginseng Research},
  year    = {2025},
  doi     = {10.1016/j.jgr.2025.07.003},
  pmid    = {41268317},
  url     = {https://doi.org/10.1016/j.jgr.2025.07.003}
}

@article{watkins2025-51cf21da,
  author  = {Watkins, Lewis M. and Nicholls, Laura E. and Lee, K. and Byrne, Robert A.J. and Cooke, Rebekah S. and Morgan, B. Paul and Sogorb‐Esteve, Aitana and Zelek, Wioleta Milena},
  title   = {{Profiling complement dysregulation in frontotemporal dementia using cerebrospinal fluid, plasma, and exosomes}},
  journal = {Immunobiology},
  year    = {2025},
  doi     = {10.1016/j.imbio.2025.152941},
  url     = {https://doi.org/10.1016/j.imbio.2025.152941}
}

@article{zou2025-40642384,
  author  = {Zou, Xin and Cai, Luo-yang and Zhang, Jin and Yuan, Ying Shu and Song, Jie Young and Hu, Zheng and Ruan, Xiao-feng and Peng, Rui and others},
  title   = {{Mechanism of heme oxygenase-1 regulation of ferroptosis in vascular dementia}},
  journal = {Frontiers in Molecular Neuroscience},
  year    = {2025},
  doi     = {10.3389/fnmol.2025.1585079},
  pmid    = {40642384},
  url     = {https://doi.org/10.3389/fnmol.2025.1585079}
}

@article{mcgill2025-40494894,
  author  = {McGill, Cassandra Joan and Christensen, Amy and Qian, Wenjie and Thorwald, Max Andrew and Godoy-Lugo, José Arquimides and Namvari, Sara and White, Olivia S. and Finch, Caleb E. and others},
  title   = {{Protection against APOE4-associated phenotypes with the longevity-promoting intervention 17α-estradiol in middle-aged male mice}},
  journal = {Communications Medicine},
  year    = {2025},
  doi     = {10.1038/s43856-025-00942-3},
  pmid    = {40494894},
  url     = {https://doi.org/10.1038/s43856-025-00942-3}
}

@article{rullmann2025-40494919,
  author  = {Rullmann, Michael and Meyer, Philipp and Schildan, Andreas and Hoffmann, Karl‐Titus and Sabri, Osama and Tiepolt, Solveig},
  title   = {{Impact of white matter hyperintensities on α4β2 nicotinic acetylcholine receptor binding in the human brain}},
  journal = {European Journal of Nuclear Medicine and Molecular Imaging},
  year    = {2025},
  doi     = {10.1007/s00259-025-07383-z},
  pmid    = {40494919},
  url     = {https://doi.org/10.1007/s00259-025-07383-z}
}

@article{smith2025-40447946,
  author  = {Smith, Ethan D. and Paterno, Giavanna and Bell, Brach M. and Gorion, Kimberly-Marie M. and Prokop, Stefan and Giasson, Benoit I.},
  title   = {{Tau from SPAM Transgenic Mice Exhibit Potent Strain-Specific Prion-Like Seeding Properties Characteristic of Human Neurodegenerative Diseases}},
  journal = {NeuroMolecular Medicine},
  year    = {2025},
  doi     = {10.1007/s12017-025-08850-4},
  pmid    = {40447946},
  url     = {https://doi.org/10.1007/s12017-025-08850-4}
}

@article{zhang2025-40521199,
  author  = {Zhang, Yueqi and Jiang, Lixian and Wu, Rongrong and Gao, Wei and Zhang, Xiaojie and Liu, Lan and Zhang, Yaxuan and others},
  title   = {{An AIM2 inflammasome biomimetic mineralization inhibitor for vascular dementia therapy}},
  journal = {Theranostics},
  year    = {2025},
  doi     = {10.7150/thno.110389},
  pmid    = {40521199},
  url     = {https://doi.org/10.7150/thno.110389}
}

@article{chikhradze2025-00095b0c,
  author  = {Chikhradze, A. and Kacharava, M. and Surmanidze, A. and Vashadze, Shorena},
  title   = {{About genotype and allele distributions of APP promoter single-nucleotide polymorphisms}},
  journal = {INTERNATIONAL NEUROLOGICAL JOURNAL},
  year    = {2025},
  doi     = {10.22141/2224-0713.21.3.2025.1172},
  url     = {https://doi.org/10.22141/2224-0713.21.3.2025.1172}
}

@article{hulse2025-40360566,
  author  = {Hulse, Jonathan P. and Maphis, Nicole M. and Peabody, Julianne and Bondu, Virginie and Chackerian, Bryce and Bhaskar, Kiran},
  title   = {{pS396/pS404 (PHF1) tau vaccine outperforms pS199/pS202 (AT8) in rTg4510 tauopathy model}},
  journal = {npj Vaccines},
  year    = {2025},
  doi     = {10.1038/s41541-025-01147-4},
  pmid    = {40360566},
  url     = {https://doi.org/10.1038/s41541-025-01147-4}
}

@article{ralph2025-40233814,
  author  = {Ralph, Buchert and Alexander, Drzezga and Mathias, Schreckenberger and Josef, Langen Karl and Meyer Philipp, T.},
  title   = {{The Status of Neuroimaging with SPECT and PET in Germany: Results from the 1st Survey on Nuclear Neuroimaging in Germany in 2023}},
  journal = {Nuklearmedizin. Nuclear medicine},
  year    = {2025},
  doi     = {10.1055/a-2566-1487},
  pmid    = {40233814},
  url     = {https://doi.org/10.1055/a-2566-1487}
}

@article{hou2025-40235770,
  author  = {Hou, Chao and Zhang, Victor Wei and Li, Fang-Xian and Li, Shuo and Yang, Lizhi and Ma, Hui-Yu and Nie, Fang and Wang, Xue-Mei and others},
  title   = {{Association between third ventricular width assessed by transcranial sonography and plasma homocysteine in Parkinson’s disease with cognitive impairment and their potential to predict conversion to dementia}},
  journal = {Quantitative Imaging in Medicine and Surgery},
  year    = {2025},
  doi     = {10.21037/qims-24-1736},
  pmid    = {40235770},
  url     = {https://doi.org/10.21037/qims-24-1736}
}

@article{kour2025-40183098,
  author  = {Kour, Dilpreet and Khajuria, Parul and Sharma, Kuhu and Sharma, Alpa and Sharma, Ankita and Ali, Syed Mudassir and Wazir, Priya and Ramajayan, P. and others},
  title   = {{Isobavachalcone ameliorates Alzheimer disease pathology by autophagy-mediated clearance of amyloid beta and inhibition of NLRP3 inflammasome in primary astrocytes and 5x-FAD mice}},
  journal = {Frontiers in Pharmacology},
  year    = {2025},
  doi     = {10.3389/fphar.2025.1525364},
  pmid    = {40183098},
  url     = {https://doi.org/10.3389/fphar.2025.1525364}
}

@article{liu2025-40183082,
  author  = {Liu, Shu and Song, Xiaochen and Sun, Yuefeng and Sun, Ailin and Li, Yang and Li, Yuyu and Chen, Jing},
  title   = {{Kai-Xin-San ameliorates mild cognitive impairment in SAMP8 mice by inhibiting neuroinflammation and pyroptosis via NLRP3/Caspase-1 pathway modulation}},
  journal = {Frontiers in Pharmacology},
  year    = {2025},
  doi     = {10.3389/fphar.2025.1528011},
  pmid    = {40183082},
  url     = {https://doi.org/10.3389/fphar.2025.1528011}
}

@article{bukrinsky2025-40144622,
  author  = {Bukrinsky, Michael},
  title   = {{Nef is a key player in neuroinflammation and myelin impairment associated with neuroHIV}},
  journal = {Frontiers in Neurology},
  year    = {2025},
  doi     = {10.3389/fneur.2025.1553594},
  pmid    = {40144622},
  url     = {https://doi.org/10.3389/fneur.2025.1553594}
}

@article{nataraj2025-40116546,
  author  = {Nataraj, Andrew and Blahna, Karel and Ježek, Karel},
  title   = {{Insights From TgF344-AD, a Double Transgenic Rat Model in Alzheimer’s Disease Research}},
  journal = {Physiological Research},
  year    = {2025},
  doi     = {10.33549/physiolres.935464},
  pmid    = {40116546},
  url     = {https://doi.org/10.33549/physiolres.935464}
}

@article{castillo2025-1162a433,
  author  = {Castillo, Darwin and Rodríguez-Álvarez, María José and Samaniego, René and Lakshminarayanan, Vasudevan},
  title   = {{Models to Identify Small Brain White Matter Hyperintensity Lesions}},
  journal = {Applied Sciences},
  year    = {2025},
  doi     = {10.3390/app15052830},
  url     = {https://doi.org/10.3390/app15052830}
}

@article{tang2025-39950843,
  author  = {Tang, Jiaxing and Wang, Feng and Xu, Zhengdong and Zou, Yu Feng and Zhang, Qingwen},
  title   = {{Mechanistic Insights into the Inhibitory and Destabilizing Effects of K353 Acetylation on Tau Peptides and Protofibrils}},
  journal = {The Journal of Physical Chemistry B},
  year    = {2025},
  doi     = {10.1021/acs.jpcb.4c07977},
  pmid    = {39950843},
  url     = {https://doi.org/10.1021/acs.jpcb.4c07977}
}

@article{huang2025-39923578,
  author  = {Huang, Ping and Sun, Hao and Chen, Yuang and Li, Jiacheng and Peng, Yuqin and Ge, Chaowen and Zhu, Kai and Zhou, Xian and others},
  title   = {{Muscone enhances synaptic function in vascular dementia through activating BDNF-TrkB-NP2 signaling pathway}},
  journal = {International Immunopharmacology},
  year    = {2025},
  doi     = {10.1016/j.intimp.2025.114232},
  pmid    = {39923578},
  url     = {https://doi.org/10.1016/j.intimp.2025.114232}
}

@article{qiu2025-39915907,
  author  = {Qiu, Yuemin and Cheng, Lin and Xiong, Yinyi and Liu, Ziying and Shen, Chunxiao and Wang, Liangliang and Lu, Yujia and Wei, Shufei and others},
  title   = {{Advances in the Study of Necroptosis in Vascular Dementia: Focus on Blood–Brain Barrier and Neuroinflammation}},
  journal = {CNS Neuroscience \& Therapeutics},
  year    = {2025},
  doi     = {10.1111/cns.70224},
  pmid    = {39915907},
  url     = {https://doi.org/10.1111/cns.70224}
}

@article{babaei2025-39980585,
  author  = {Babaei, Farnaz Ghayour and Saburi, Ehsan and Forouzanfar, Fatemeh and Asgari, Mohadese and Keshavarzi, Zakieh and Hajali, Vahid},
  title   = {{Effect of epigallocatechin-3-gallate (EGCG) on cognitive functioning and the expression of APP and BDNF in the hippocampus of rats with streptozotocin -induced Alzheimer-like disease}},
  journal = {Biochemistry and Biophysics Reports},
  year    = {2025},
  doi     = {10.1016/j.bbrep.2025.101930},
  pmid    = {39980585},
  url     = {https://doi.org/10.1016/j.bbrep.2025.101930}
}

@article{oldhammark2024-38503671,
  author  = {Oldham Mark, A. and Thomas, Heinrich and James, Luccarelli},
  title   = {{Requesting That Delirium Achieve Parity With Acute Encephalopathy in the MS-DRG System}},
  journal = {Journal of the Academy of Consultation-Liaison Psychiatry},
  year    = {2024},
  doi     = {10.1016/j.jaclp.2024.02.004},
  pmid    = {38503671},
  url     = {https://doi.org/10.1016/j.jaclp.2024.02.004}
}

@article{huf2024-37874493,
  author  = {Huf, F. and Gutierres, J. M. and da Silva, G. N. and Zago, A. M. and Koenig, L. F. C. and Fernandes, M. C.},
  title   = {{Neuroprotection elicited by taurine in sporadic Alzheimer-like disease: benefits on memory and control of neuroinflammation in the hippocampus of rats}},
  journal = {Molecular and cellular biochemistry},
  year    = {2024},
  doi     = {10.1007/s11010-023-04872-3},
  pmid    = {37874493},
  url     = {https://doi.org/10.1007/s11010-023-04872-3}
}

@article{merkel2022-a693eb78,
  author  = {Merkel, Emily X. and Ennis, Gilda E. and Cadman, Robert V. and Koscik, Rebecca L. and Ma, Yue and Asthana, Sanjay and Johnson, Sterling C. and Kind, Amy and others},
  title   = {{Testing the Association Between Neighborhood Disadvantage and White Matter Hyperintensities}},
  journal = {Alzheimer s \& Dementia},
  year    = {2022},
  doi     = {10.1002/alz.069324},
  url     = {https://doi.org/10.1002/alz.069324}
}

@article{mazzarino2021-34283828,
  author  = {Mazzarino, R. C. and Baresova, V. and Zikánová, M. and Duval, N. and Wilkinson, T. G. and Patterson, D. and Vacano, G. N.},
  title   = {{Transcriptome and metabolome analysis of crGART, a novel cell model of de novo purine synthesis deficiency: Alterations in CD36 expression and activity}},
  journal = {PloS one},
  year    = {2021},
  doi     = {10.1371/journal.pone.0247227},
  pmid    = {34283828},
  url     = {https://doi.org/10.1371/journal.pone.0247227}
}

@article{mandour2021-34170456,
  author  = {Mandour, D. A. and Bendary, M. A. and Alsemeh, A. E.},
  title   = {{Histological and imunohistochemical alterations of hippocampus and prefrontal cortex in a rat model of Alzheimer like-disease with a preferential role of the flavonoid "hesperidin"}},
  journal = {Journal of molecular histology},
  year    = {2021},
  doi     = {10.1007/s10735-021-09998-6},
  pmid    = {34170456},
  url     = {https://doi.org/10.1007/s10735-021-09998-6}
}

@article{gonzalezmolina2021-33679370,
  author  = {González-Molina, L. A. and Villar-Vesga, J. and Henao-Restrepo, J. and Villegas, A. and Lopera, F. and Cardona-Gómez, G. P. and Posada-Duque, R.},
  title   = {{Extracellular Vesicles From 3xTg-AD Mouse and Alzheimer's Disease Patient Astrocytes Impair Neuroglial and Vascular Components}},
  journal = {Frontiers in aging neuroscience},
  year    = {2021},
  doi     = {10.3389/fnagi.2021.593927},
  pmid    = {33679370},
  url     = {https://doi.org/10.3389/fnagi.2021.593927}
}

@article{vasta2021-33563811,
  author  = {Vasta, Rosario and Canosa, Antonio and Manera, Umberto and Di Pede, Francesca and Cabras, Sara and De Marchi, Fabiola and Mazzini, Letizia and Moglia, Cristina and others},
  title   = {{Do ecological factors influence the clinical presentation of amyotrophic lateral sclerosis?}},
  journal = {Journal of Neurology Neurosurgery \& Psychiatry},
  year    = {2021},
  doi     = {10.1136/jnnp-2020-325625},
  pmid    = {33563811},
  url     = {https://doi.org/10.1136/jnnp-2020-325625}
}

@article{tapp2020-32164485,
  author  = {Tapp, Z. M. and Kumar, J. E. and Witcher, K. G. and Atluri, R. R. and Velasquez, J. A. and O'Neil, S. M. and Dziabis, J. E. and Bray, C. E. and others},
  title   = {{Sleep Disruption Exacerbates and Prolongs the Inflammatory Response to Traumatic Brain Injury}},
  journal = {Journal of neurotrauma},
  year    = {2020},
  doi     = {10.1089/neu.2020.7010},
  pmid    = {32164485},
  url     = {https://doi.org/10.1089/neu.2020.7010}
}

@article{long2019-31134514,
  author  = {Long, H. and Zhong, G. and Wang, C. and Zhang, J. and Zhang, Y. and Luo, J. and Shi, S.},
  title   = {{TREM2 Attenuates Aβ1-42-Mediated Neuroinflammation in BV-2 Cells by Downregulating TLR Signaling}},
  journal = {Neurochemical research},
  year    = {2019},
  doi     = {10.1007/s11064-019-02817-1},
  pmid    = {31134514},
  url     = {https://doi.org/10.1007/s11064-019-02817-1}
}

@article{of2017-28342141,
  author  = {ÖF, Demirel and Cetin, I. and Ş, Turan and Yıldız, N. and Sağlam, T. and Duran, A.},
  title   = {{Total Tau and Phosphorylated Tau Protein Serum Levels in Patients with Schizophrenia Compared with Controls}},
  journal = {The Psychiatric quarterly},
  year    = {2017},
  doi     = {10.1007/s11126-017-9507-x},
  pmid    = {28342141},
  url     = {https://doi.org/10.1007/s11126-017-9507-x}
}

@article{daschil2016-27092076,
  author  = {Daschil, N. and Humpel, C.},
  title   = {{Green-Fluorescent Protein(+) Astrocytes Attach to Beta-Amyloid Plaques in an Alzheimer Mouse Model and Are Sensitive for Clasmatodendrosis}},
  journal = {Frontiers in aging neuroscience},
  year    = {2016},
  doi     = {10.3389/fnagi.2016.00075},
  pmid    = {27092076},
  url     = {https://doi.org/10.3389/fnagi.2016.00075}
}

@article{hamlett2016-26391050,
  author  = {Hamlett, E. D. and Boger, H. A. and Ledreux, A. and Kelley, C. M. and Mufson, E. J. and Falangola, M. F. and Guilfoyle, D. N. and Nixon, R. A. and others},
  title   = {{Cognitive Impairment, Neuroimaging, and Alzheimer Neuropathology in Mouse Models of Down Syndrome}},
  journal = {Current Alzheimer research},
  year    = {2016},
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  title   = {{Human TDP-43 expression worsens FTD-related phenotypes in progranulin-insufficient mice}},
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  title   = {{Transcriptome-informed metabolic modeling reveals astrocyte-specific vulnerabilities in mild cognitive impairment and Alzheimer’s disease progression}},
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  title   = {{Porphyromonas gingivalis disrupts hippocampal circadian clock via PI3K/AKT pathway, exacerbating Alzheimer‐like pathology}},
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  title   = {{Autophagosome-targeting single-domain antibody clears tau in patient-derived neurons and improves motor function in tauopathy mice}},
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  title   = {{Human TDP-43 overexpression in zebrafish motor neurons triggers MND-like phenotypes through gain-of-function mechanism}},
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  title   = {{Functional connectivity differences in the default mode and frontoparietal networks in older adults with Down syndrome are related to obstructive sleep apnea}},
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  title   = {{Distinct Sensitivity of MRI Versus [ 18 F]FDG‐PET To Detect Cerebral Changes Across the Alzheimer's Continuum in Down Syndrome: A Multimodal Imaging Study}},
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@article{coles2025-41238048,
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  title   = {{A modified α-synuclein seed amplification assay in Lewy body dementia using Raman spectroscopy and machine learning analysis}},
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  title   = {{A deep dive into statistical modeling of RNA splicing QTLs reveals variants that explain neurodegenerative disease}},
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@article{pluta2025-41245147,
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  title   = {{Characterization of endothelin-converting enzyme 1 as a key enzyme in the multienzyme Aβ degradation pathway}},
  journal = {Proceedings of the National Academy of Sciences},
  year    = {2025},
  doi     = {10.1073/pnas.2507450122},
  pmid    = {41144673},
  url     = {https://doi.org/10.1073/pnas.2507450122}
}

@article{xu2025-41138884,
  author  = {Xu, Yuan and Peng, Ya and Zhi, Feng and Yang, Yilin and Li, Jiahui and Fan, Ligang and Xia, Ying and Shao, Nan},
  title   = {{Delta-opioid receptor ameliorates microglia-induced synapse loss by regulating C1q in Alzheimer disease pathology}},
  journal = {Brain Behavior and Immunity},
  year    = {2025},
  doi     = {10.1016/j.bbi.2025.106149},
  pmid    = {41138884},
  url     = {https://doi.org/10.1016/j.bbi.2025.106149}
}

@article{tang2025-41129691,
  author  = {Tang, Jiaxing and Feng, Dushuo and Guan, Lulu and Qi, Bote and Zou, Yu Feng},
  title   = {{Computational Insights into the Destabilization of Baicalein on the Tau Protofibrils Associated with Alzheimer’ s Disease and Chronic Traumatic Encephalopathy}},
  journal = {The Journal of Physical Chemistry B},
  year    = {2025},
  doi     = {10.1021/acs.jpcb.5c05778},
  pmid    = {41129691},
  url     = {https://doi.org/10.1021/acs.jpcb.5c05778}
}

@article{ryoo2025-41059602,
  author  = {Ryoo, Si Won and Lin, William Z. and Magliocco, Alexandra and Ruthirakuhan, Myuri T. and Wong, Yuen Yan and Perfetto, Sofia E. and Huang, Celine and Anita, Natasha Z. and others},
  title   = {{Metabolic and vascular contributions to dementia: Soluble epoxide hydrolase‐derived linoleic acid oxylipins and glycemic status are related to cerebral small vessel disease markers, atrophy, and cognitive performance}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz.70718},
  pmid    = {41059602},
  url     = {https://doi.org/10.1002/alz.70718}
}

@article{lu2025-40893564,
  author  = {Lu, Wenli and Yang, Li and Chen, Ran and Chen, Xinyi and Zhu, Shengnan and Ji, Liya and Liao, Han-Tsung and Qiang, Jing and others},
  title   = {{An exploratory study of the diffusion tensor imaging analysis along perivascular spaces (DTI-ALPS) index combined with quantitative analysis of choroid plexus volume and perivascular spaces in different cognitive stages of cerebral small vessel disease}},
  journal = {Quantitative Imaging in Medicine and Surgery},
  year    = {2025},
  doi     = {10.21037/qims-2025-733},
  pmid    = {40893564},
  url     = {https://doi.org/10.21037/qims-2025-733}
}

@article{galamba2025-feffdf1a,
  author  = {Galamba, Elizabeth},
  title   = {{The Hidden Global Health Crisis of Omega-3 Deficiency}},
  journal = {Oncology Times},
  year    = {2025},
  doi     = {10.1097/01.cot.0000000000000129},
  url     = {https://doi.org/10.1097/01.cot.0000000000000129}
}

@article{yamamoto2025-40707862,
  author  = {Yamamoto, Y. and Kubota, Toshiki and Noguchi, Daisuke and Saido, Takaomi C. and Ohshima, Toshio},
  title   = {{Co-Expression of Mutant Tau and α-Synuclein in Neurons Promotes Tau Phosphorylation, Neuronal Loss, and Neuroinflammation in Mouse Brain}},
  journal = {Molecular Neurobiology},
  year    = {2025},
  doi     = {10.1007/s12035-025-05248-y},
  pmid    = {40707862},
  url     = {https://doi.org/10.1007/s12035-025-05248-y}
}

@article{bernhardt2025-40713844,
  author  = {Bernhardt, Alexander Maximilian and Roeber, Sigrun and Ruf, Viktoria and Wlasich, Elisabeth and Weidinger, Endy and Longen, Sebastian and Trossbach, Svenja Verena and Gnörich, Johannes S. and others},
  title   = {{Co-occurrence of multiple pathologies in a case of frontotemporal dementia with TBK1 mutation: first in vivo detection of alpha-synuclein and tau co-pathology}},
  journal = {Acta Neuropathologica Communications},
  year    = {2025},
  doi     = {10.1186/s40478-025-02081-1},
  pmid    = {40713844},
  url     = {https://doi.org/10.1186/s40478-025-02081-1}
}

@article{masegosa2025-40671688,
  author  = {Masegosa, Vera M. and Fritz, Elsa and Corvalán, Daniela and Rojas, Fabiola and Garcés, Polett and Navarro, Xavier and Bloms‐Funke, Petra and van Zundert, Brigitte and others},
  title   = {{Novel Dual Mechanism GRT-X Agonist Acting on Kv7 Potassium Channel/Translocator Protein Receptor Prevents Motoneuron Degeneration Following Exposure to Mouse and Human Amyotrophic Lateral Sclerosis/Frontotemporal Dementia Astrocyte-Conditioned Media}},
  journal = {ACS Chemical Neuroscience},
  year    = {2025},
  doi     = {10.1021/acschemneuro.5c00197},
  pmid    = {40671688},
  url     = {https://doi.org/10.1021/acschemneuro.5c00197}
}

@article{du2025-40539508,
  author  = {Du, Miaomiao and Wang, Yujia and Wang, Xinyuan and Liu, Yifei and Xiao, Fuchuan and Zhang, Jing and Meng, Xia and Ma, Kunhe and others},
  title   = {{Age‐Related Complement C3 Drives Memory Impairments and Associated Neuropathologies in a Mouse Model}},
  journal = {Aging Cell},
  year    = {2025},
  doi     = {10.1111/acel.70145},
  pmid    = {40539508},
  url     = {https://doi.org/10.1111/acel.70145}
}

@article{delval2025-40518671,
  author  = {del Val, Greg and Gauye, Florence and Audrain, Mickaël and Menant, Sébastien and Ratnam, Monisha and Chevalier, Elodie and Ollier, Romain and Bhatia, Daisy and others},
  title   = {{A single dose of a vectorized mAb targeting TDP-43 potently inhibits the neuropathology in a model of ALS/FTD}},
  journal = {Molecular Therapy},
  year    = {2025},
  doi     = {10.1016/j.ymthe.2025.06.026},
  pmid    = {40518671},
  url     = {https://doi.org/10.1016/j.ymthe.2025.06.026}
}

@article{reyes2025-40495448,
  author  = {Reyes, Fernanda S. Peralta and Sommerhage, Simon and Willbold, Dieter and Schröder, Gunnar F. and Gremer, Lothar},
  title   = {{Lecanemab Binds to Transgenic Mouse Model‐Derived Amyloid‐β Fibril Structures Resembling Alzheimer's Disease Type I, Type II and Arctic Folds}},
  journal = {Neuropathology and Applied Neurobiology},
  year    = {2025},
  doi     = {10.1111/nan.70022},
  pmid    = {40495448},
  url     = {https://doi.org/10.1111/nan.70022}
}

@article{yu2025-40543993,
  author  = {Yu, Mingjing and Qi, Zhi and Zhang, Jiaxin and Zhang, Ziyi and Chen, Jieli and Yan, Tao and Chen, Zhili},
  title   = {{Targeting CD38 to alleviate brain endothelial cell dysfunction and cognitive impairment in vascular dementia}},
  journal = {Journal of Pharmacological Sciences},
  year    = {2025},
  doi     = {10.1016/j.jphs.2025.05.013},
  pmid    = {40543993},
  url     = {https://doi.org/10.1016/j.jphs.2025.05.013}
}

@article{bougea2025-40392273,
  author  = {Bougea, A. and Colosimo, C. and Falup-Pecurariu, C. and Palermo, G. and Degirmenci, Y.},
  title   = {{Fluid biomarkers in atypical Parkinsonism: current state and future perspectives}},
  journal = {Journal of neural transmission (Vienna, Austria : 1996)},
  year    = {2025},
  doi     = {10.1007/s00702-025-02930-2},
  pmid    = {40392273},
  url     = {https://doi.org/10.1007/s00702-025-02930-2}
}

@article{bu2025-40337511,
  author  = {Bu, Yifan and Li, Songzhe and Ye, Ting and Wang, Yuqing and Song, Mingrong and Chen, Jing},
  title   = {{Volatile oil of Acori tatarinowii rhizoma: potential candidate drugs for mitigating dementia}},
  journal = {Frontiers in Pharmacology},
  year    = {2025},
  doi     = {10.3389/fphar.2025.1552801},
  pmid    = {40337511},
  url     = {https://doi.org/10.3389/fphar.2025.1552801}
}

@article{zuo2025-40249934,
  author  = {Zuo, X.},
  title   = {{Mitochondrial Imbalance in Down Syndrome: A Driver of Accelerated Brain Aging?}},
  journal = {Aging and disease},
  year    = {2025},
  doi     = {10.14336/ad.2025.0189},
  pmid    = {40249934},
  url     = {https://doi.org/10.14336/ad.2025.0189}
}

@article{dunacka2025-40283962,
  author  = {Dunacka, Joanna and Grembecka, Beata and Majkutewicz, Irena and Wrona, Danuta},
  title   = {{Central Insulin-like Growth Factor-1 Treatment Enhances Working and Reference Memory by Reducing Neuroinflammation and Amyloid Beta Deposition in a Rat Model of Sporadic Alzheimer’s Disease}},
  journal = {Pharmaceuticals},
  year    = {2025},
  doi     = {10.3390/ph18040527},
  pmid    = {40283962},
  url     = {https://doi.org/10.3390/ph18040527}
}

@article{ding2025-39936620,
  author  = {Ding, N. and Song, Y. and Zhang, Y. and Yu, W. and Li, X. and Li, W. and Li, L.},
  title   = {{Heat-shock chaperone HSPB1 mitigates poly-glycine-induced neurodegeneration via restoration of autophagic flux}},
  journal = {Autophagy},
  year    = {2025},
  doi     = {10.1080/15548627.2025.2466144},
  pmid    = {39936620},
  url     = {https://doi.org/10.1080/15548627.2025.2466144}
}

@article{graur2025-39992414,
  author  = {Graur, Alexandru and Erickson, Natalie and Sinclair, Patricia and Nusir, Aya and Kabbani, Nadine},
  title   = {{HIV-1 gp120 Interactions with Nicotine Modulate Mitochondrial Network Properties and Amyloid Release in Microglia}},
  journal = {Neurochemical Research},
  year    = {2025},
  doi     = {10.1007/s11064-025-04357-3},
  pmid    = {39992414},
  url     = {https://doi.org/10.1007/s11064-025-04357-3}
}

@article{nuovo2025-39931956,
  author  = {Nuovo, Gerard J. and Rice, Madison and Zanesi, Nicola A. O. and Sawant, Dwitiya B. and Crilly, Candice J. and Tili, Esmerina},
  title   = {{The Prevention of Fatal Tauopathy in a Mouse Model of Alzheimer Disease by Blocking BCL2}},
  journal = {Applied immunohistochemistry \& molecular morphology},
  year    = {2025},
  doi     = {10.1097/pai.0000000000001251},
  pmid    = {39931956},
  url     = {https://doi.org/10.1097/pai.0000000000001251}
}

@article{hornung2025-276be469,
  author  = {Hornung, Simon and Vogl, Dominik P. and Naltsas, Denise and Volta, Beatrice Dalla and Ballmann, Markus and Marcon, Beatrice and Syed, Muhammed Muazzam Kamil and Wu, Yiyang and others},
  title   = {{Multi‐Targeting Makrozyklische Peptide als Nanomolare Inhibitoren der Selbst‐ und Kreuznukleation der Amyloiden Selbstassemblierung von α‐Synuclein}},
  journal = {Angewandte Chemie},
  year    = {2025},
  doi     = {10.1002/ange.202422834},
  url     = {https://doi.org/10.1002/ange.202422834}
}

@article{yang2025-39834810,
  author  = {Yang, Chaokai and Zhao, Enlong and Zhang, Hu and Duan, Li-Qi and Han, Xinyue and Ding, Hongli and Cheng, Yan and Wang, Dengkun and others},
  title   = {{Xixin Decoction’s novel mechanism for alleviating Alzheimer’s disease cognitive dysfunction by modulating amyloid-β transport across the blood–brain barrier to reduce neuroinflammation}},
  journal = {Frontiers in Pharmacology},
  year    = {2025},
  doi     = {10.3389/fphar.2024.1508726},
  pmid    = {39834810},
  url     = {https://doi.org/10.3389/fphar.2024.1508726}
}

@article{garniercrussard2025-41312509,
  author  = {Garnier‐Crussard, Antoine and Sadr, Alexandre Bani and Quadrio, Isabelle and Formaglio, Maïté and Desestret, Virginie and Tournier‐Lasserve, Elisabeth and Coste, Thibault},
  title   = {{Late-onset dementia with leukoencephalopathy and a COL4A2 gene variant, causal link or fortuitous association: a case report}},
  journal = {Cerebral Circulation - Cognition and Behavior},
  year    = {2025},
  doi     = {10.1016/j.cccb.2025.100518},
  pmid    = {41312509},
  url     = {https://doi.org/10.1016/j.cccb.2025.100518}
}

@article{demoraes2024-39596576,
  author  = {de Moraes, Ruan Carlos Macêdo and Roth, Jonathan R. and Mao, Hailey and Crawley, Savannah R. and Xu, Brittney P. and Watson, John C. and Melkani, Girish C.},
  title   = {{Apolipoprotein E Induces Lipid Accumulation Through Dgat2 That Is Prevented with Time-Restricted Feeding in Drosophila}},
  journal = {Genes},
  year    = {2024},
  doi     = {10.3390/genes15111376},
  pmid    = {39596576},
  url     = {https://doi.org/10.3390/genes15111376}
}

@article{murthy2024-39339550,
  author  = {Murthy, Hosakatte Niranjana and Yadav, Guggalada Govardhana and Paek, Kee‐Yoeup and Park, So‐Young},
  title   = {{Production of Terpene Trilactones from Cell and Organ Cultures of Ginkgo biloba}},
  journal = {Plants},
  year    = {2024},
  doi     = {10.3390/plants13182575},
  pmid    = {39339550},
  url     = {https://doi.org/10.3390/plants13182575}
}

@article{betters2022-5909f2fc,
  author  = {Betters, R. K. and Luhmann, E. and Gottschalk, A. C. and Xu, Z. and Ptak, C. P. and Fiock, K. L. and Radoshevich, L. C. and Hefti, M. M.},
  title   = {{Characterization of the Tau Interactome in Human Brain Reveals Isoform-Dependent Interaction with 14-3-3 Family Proteins}},
  journal = {eNeuro},
  year    = {2022},
  doi     = {10.1101/2022.10.17.512532},
  url     = {https://doi.org/10.1101/2022.10.17.512532}
}

@article{im2022-4ba4a0f3,
  author  = {Im, E. and Jiang, Y. and Stavrides, P. and Darji, S. and Erdjument-Bromage, H. and Neubert, T. A. and Choi, J. Y. and Wegiel, J. and others},
  title   = {{Lysosomal dysfunction in Down Syndrome and Alzheimer mouse models is caused by selective v-ATPase inhibition by Tyr 682 phosphorylated APP βCTF}},
  journal = {Science advances},
  year    = {2022},
  doi     = {10.1101/2022.06.02.494546},
  url     = {https://doi.org/10.1101/2022.06.02.494546}
}

@article{saviano2021-33845375,
  author  = {Saviano, A. and Casillo, G. M. and Raucci, F. and Pernice, A. and Santarcangelo, C. and Piccolo, M. and Ferraro, M. G. and Ciccone, M. and others},
  title   = {{Supplementation with ribonucleotide-based ingredient (Ribodiet®) lessens oxidative stress, brain inflammation, and amyloid pathology in a murine model of Alzheimer}},
  journal = {Biomedicine \& pharmacotherapy = Biomedecine \& pharmacotherapie},
  year    = {2021},
  doi     = {10.1016/j.biopha.2021.111579},
  pmid    = {33845375},
  url     = {https://doi.org/10.1016/j.biopha.2021.111579}
}

@article{kim2021-33332107,
  author  = {Kim, D. and Bae, G. H. and Kim, H. Y. and Jeon, H. and Kim, K. and Shin, J. and Lee, S. and Hong, S. and others},
  title   = {{Orally Administered Benzofuran Derivative Disaggregated Aβ Plaques and Oligomers in the Brain of 5XFAD Alzheimer Transgenic Mouse}},
  journal = {ACS chemical neuroscience},
  year    = {2021},
  doi     = {10.1021/acschemneuro.0c00606},
  pmid    = {33332107},
  url     = {https://doi.org/10.1021/acschemneuro.0c00606}
}

@article{decarlo2020-f7466f98,
  author  = {DeCarlo, Kristen and O’Brien, Matthew T. and Liss, David T. and Kang, Raymond H. and Cooper, Andrew and Cherupally, Manisha and Parker, Emily D. and Aikman, Cassandra and others},
  title   = {{1414-P: Characteristics Associated with Sulfonylureas and Basal Insulin Use following Metformin in Older Adults}},
  journal = {Diabetes},
  year    = {2020},
  doi     = {10.2337/db20-1414-p},
  url     = {https://doi.org/10.2337/db20-1414-p}
}

@article{reeves2019-30800043,
  author  = {Reeves, R. H. and Delabar, J. and Potier, M. C. and Bhattacharyya, A. and Head, E. and Lemere, C. and Dekker, A. D. and De Deyn, P. and others},
  title   = {{Paving the Way for Therapy: The Second International Conference of the Trisomy 21 Research Society}},
  journal = {Molecular syndromology},
  year    = {2019},
  doi     = {10.1159/000494231},
  pmid    = {30800043},
  url     = {https://doi.org/10.1159/000494231}
}

@article{remmler2018-29964137,
  author  = {Remmler, D. and Schwaar, T. and Pickhardt, M. and Donth, C. and Mandelkow, E. and Weller, M. G. and Börner, H. G.},
  title   = {{On the way to precision formulation additives: 2D-screening to select solubilizers with tailored host and release capabilities}},
  journal = {Journal of controlled release : official journal of the Controlled Release Society},
  year    = {2018},
  doi     = {10.1016/j.jconrel.2018.06.032},
  pmid    = {29964137},
  url     = {https://doi.org/10.1016/j.jconrel.2018.06.032}
}

@article{deming2018-3f7a9435,
  author  = {Deming, Y. and Filipello, F. and Cignarella, F. and Cantoni, C. and Hsu, S. and Mikesell, R. and Li, Z. and Del-Aguila, J. L. and others},
  title   = {{The MS4A gene cluster is a key regulator of soluble TREM2 and Alzheimer disease risk}},
  journal = {Science translational medicine},
  year    = {2018},
  doi     = {10.1101/352179},
  url     = {https://doi.org/10.1101/352179}
}

@article{monzon2018-29642165,
  author  = {Monzón, M. and Hernández, R. S. and Garcés, M. and Sarasa, R. and Badiola, J. J.},
  title   = {{Glial alterations in human prion diseases: A correlative study of astroglia, reactive microglia, protein deposition, and neuropathological lesions}},
  journal = {Medicine},
  year    = {2018},
  doi     = {10.1097/md.0000000000010320},
  pmid    = {29642165},
  url     = {https://doi.org/10.1097/md.0000000000010320}
}

@article{deleye2017-28611242,
  author  = {Deleye, S. and Waldron, A. M. and Verhaeghe, J. and Bottelbergs, A. and Wyffels, L. and Van Broeck, B. and Langlois, X. and Schmidt, M. and others},
  title   = {{Evaluation of Small-Animal PET Outcome Measures to Detect Disease Modification Induced by BACE Inhibition in a Transgenic Mouse Model of Alzheimer Disease}},
  journal = {Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year    = {2017},
  doi     = {10.2967/jnumed.116.187625},
  pmid    = {28611242},
  url     = {https://doi.org/10.2967/jnumed.116.187625}
}

@article{haller2016-27755938,
  author  = {Haller, S. and Zaharchuk, G. and Thomas, D. L. and Lovblad, K. O. and Barkhof, F. and Golay, X.},
  title   = {{Arterial Spin Labeling Perfusion of the Brain: Emerging Clinical Applications}},
  journal = {Radiology},
  year    = {2016},
  doi     = {10.1148/radiol.2016150789},
  pmid    = {27755938},
  url     = {https://doi.org/10.1148/radiol.2016150789}
}

@article{lanedonovan2016-27683909,
  author  = {Lane-Donovan, C. and Wong, W. M. and Durakoglugil, M. S. and Wasser, C. R. and Jiang, S. and Xian, X. and Herz, J.},
  title   = {{Genetic Restoration of Plasma ApoE Improves Cognition and Partially Restores Synaptic Defects in ApoE-Deficient Mice}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2016},
  doi     = {10.1523/jneurosci.1054-16.2016},
  pmid    = {27683909},
  url     = {https://doi.org/10.1523/jneurosci.1054-16.2016}
}

@article{lenart2016-27486046,
  author  = {Lénárt, N. and Brough, D. and Á, Dénes},
  title   = {{Inflammasomes link vascular disease with neuroinflammation and brain disorders}},
  journal = {Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year    = {2016},
  doi     = {10.1177/0271678x16662043},
  pmid    = {27486046},
  url     = {https://doi.org/10.1177/0271678x16662043}
}

@article{crino2016-27340022,
  author  = {Crino, P. B.},
  title   = {{The mTOR signalling cascade: paving new roads to cure neurological disease}},
  journal = {Nature reviews. Neurology},
  year    = {2016},
  doi     = {10.1038/nrneurol.2016.81},
  pmid    = {27340022},
  url     = {https://doi.org/10.1038/nrneurol.2016.81}
}

@article{dorard2016-27460148,
  author  = {Dorard, E. and Gorisse-Hussonnois, L. and Guihenneuc-Jouyaux, C. and Albac, C. and Potier, M. C. and Allinquant, B.},
  title   = {{Increases of SET level and translocation are correlated with tau hyperphosphorylation at ser202/thr205 in CA1 of Ts65Dn mice}},
  journal = {Neurobiology of aging},
  year    = {2016},
  doi     = {10.1016/j.neurobiolaging.2016.06.010},
  pmid    = {27460148},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2016.06.010}
}

@article{gitler2016-27059391,
  author  = {Gitler, A. D. and Tsuiji, H.},
  title   = {{There has been an awakening: Emerging mechanisms of C9orf72 mutations in FTD/ALS}},
  journal = {Brain research},
  year    = {2016},
  doi     = {10.1016/j.brainres.2016.04.004},
  pmid    = {27059391},
  url     = {https://doi.org/10.1016/j.brainres.2016.04.004}
}

@article{tracy2016-27041503,
  author  = {Tracy, T. E. and Sohn, P. D. and Minami, S. S. and Wang, C. and Min, S. W. and Li, Y. and Zhou, Y. and Le, D. and others},
  title   = {{Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss}},
  journal = {Neuron},
  year    = {2016},
  doi     = {10.1016/j.neuron.2016.03.005},
  pmid    = {27041503},
  url     = {https://doi.org/10.1016/j.neuron.2016.03.005}
}

@article{hwang2016-26910914,
  author  = {Hwang, C. J. and Park, M. H. and Hwang, J. Y. and Kim, J. H. and Yun, N. Y. and Oh, S. Y. and Song, J. K. and Seo, H. O. and others},
  title   = {{CCR5 deficiency accelerates lipopolysaccharide-induced astrogliosis, amyloid-beta deposit and impaired memory function}},
  journal = {Oncotarget},
  year    = {2016},
  doi     = {10.18632/oncotarget.7453},
  pmid    = {26910914},
  url     = {https://doi.org/10.18632/oncotarget.7453}
}

@article{leszek2016-26831258,
  author  = {Leszek, J. and Barreto, G. E. and Gąsiorowski, K. and Koutsouraki, E. and Ávila-Rodrigues, M. and Aliev, G.},
  title   = {{Inflammatory Mechanisms and Oxidative Stress as Key Factors Responsible for Progression of Neurodegeneration: Role of Brain Innate Immune System}},
  journal = {CNS \& neurological disorders drug targets},
  year    = {2016},
  doi     = {10.2174/1871527315666160202125914},
  pmid    = {26831258},
  url     = {https://doi.org/10.2174/1871527315666160202125914}
}

@article{kanaan2016-26671985,
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  title   = {{Characterization of Early Pathological Tau Conformations and Phosphorylation in Chronic Traumatic Encephalopathy}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2016},
  doi     = {10.1093/jnen/nlv001},
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  url     = {https://doi.org/10.1093/jnen/nlv001}
}

@article{booth2016-26758828,
  author  = {Booth, C. A. and Witton, J. and Nowacki, J. and Tsaneva-Atanasova, K. and Jones, M. W. and Randall, A. D. and Brown, J. T.},
  title   = {{Altered Intrinsic Pyramidal Neuron Properties and Pathway-Specific Synaptic Dysfunction Underlie Aberrant Hippocampal Network Function in a Mouse Model of Tauopathy}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2016},
  doi     = {10.1523/jneurosci.2151-15.2016},
  pmid    = {26758828},
  url     = {https://doi.org/10.1523/jneurosci.2151-15.2016}
}

@article{platt2016-26701291,
  author  = {Platt, T. L. and Beckett, T. L. and Kohler, K. and Niedowicz, D. M. and Murphy, M. P.},
  title   = {{Obesity, diabetes, and leptin resistance promote tau pathology in a mouse model of disease}},
  journal = {Neuroscience},
  year    = {2016},
  doi     = {10.1016/j.neuroscience.2015.12.011},
  pmid    = {26701291},
  url     = {https://doi.org/10.1016/j.neuroscience.2015.12.011}
}

@article{geschwind2015-26633779,
  author  = {Geschwind, M. D.},
  title   = {{Prion Diseases}},
  journal = {Continuum (Minneapolis, Minn.)},
  year    = {2015},
  doi     = {10.1212/con.0000000000000251},
  pmid    = {26633779},
  url     = {https://doi.org/10.1212/con.0000000000000251}
}

@article{ishiki2016-26485083,
  author  = {Ishiki, A. and Kamada, M. and Kawamura, Y. and Terao, C. and Shimoda, F. and Tomita, N. and Arai, H. and Furukawa, K.},
  title   = {{Glial fibrillar acidic protein in the cerebrospinal fluid of Alzheimer's disease, dementia with Lewy bodies, and frontotemporal lobar degeneration}},
  journal = {Journal of neurochemistry},
  year    = {2016},
  doi     = {10.1111/jnc.13399},
  pmid    = {26485083},
  url     = {https://doi.org/10.1111/jnc.13399}
}

@article{asadi2015-26484504,
  author  = {Asadi, F. and Jamshidi, A. H. and Khodagholi, F. and Yans, A. and Azimi, L. and Faizi, M. and Vali, L. and Abdollahi, M. and others},
  title   = {{Reversal effects of crocin on amyloid β-induced memory deficit: Modification of autophagy or apoptosis markers}},
  journal = {Pharmacology, biochemistry, and behavior},
  year    = {2015},
  doi     = {10.1016/j.pbb.2015.10.011},
  pmid    = {26484504},
  url     = {https://doi.org/10.1016/j.pbb.2015.10.011}
}

@article{morgan2015-26483679,
  author  = {Morgan, T. E. and Finch, C. E.},
  title   = {{Astrocytic estrogen receptors and impaired neurotrophic responses in a rat model of perimenopause}},
  journal = {Frontiers in aging neuroscience},
  year    = {2015},
  doi     = {10.3389/fnagi.2015.00179},
  pmid    = {26483679},
  url     = {https://doi.org/10.3389/fnagi.2015.00179}
}

@article{zhao2015-26335643,
  author  = {Zhao, Y. and Tseng, I. C. and Heyser, C. J. and Rockenstein, E. and Mante, M. and Adame, A. and Zheng, Q. and Huang, T. and others},
  title   = {{Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis}},
  journal = {Neuron},
  year    = {2015},
  doi     = {10.1016/j.neuron.2015.08.020},
  pmid    = {26335643},
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@article{lisofsky2015-26057590,
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  title   = {{Hippocampal volume and functional connectivity changes during the female menstrual cycle}},
  journal = {NeuroImage},
  year    = {2015},
  doi     = {10.1016/j.neuroimage.2015.06.012},
  pmid    = {26057590},
  url     = {https://doi.org/10.1016/j.neuroimage.2015.06.012}
}

@article{acharya2015-25960348,
  author  = {Acharya, N. K. and Goldwaser, E. L. and Forsberg, M. M. and Godsey, G. A. and Johnson, C. A. and Sarkar, A. and DeMarshall, C. and Kosciuk, M. C. and others},
  title   = {{Sevoflurane and Isoflurane induce structural changes in brain vascular endothelial cells and increase blood-brain barrier permeability: Possible link to postoperative delirium and cognitive decline}},
  journal = {Brain research},
  year    = {2015},
  doi     = {10.1016/j.brainres.2015.04.054},
  pmid    = {25960348},
  url     = {https://doi.org/10.1016/j.brainres.2015.04.054}
}

@article{iglesias2015-25936807,
  author  = {Iglesias, J. E. and Augustinack, J. C. and Nguyen, K. and Player, C. M. and Player, A. and Wright, M. and Roy, N. and Frosch, M. P. and others},
  title   = {{A computational atlas of the hippocampal formation using ex vivo, ultra-high resolution MRI: Application to adaptive segmentation of in vivo MRI}},
  journal = {NeuroImage},
  year    = {2015},
  doi     = {10.1016/j.neuroimage.2015.04.042},
  pmid    = {25936807},
  url     = {https://doi.org/10.1016/j.neuroimage.2015.04.042}
}

@article{kreutzmann2015-25937398,
  author  = {Kreutzmann, J. C. and Havekes, R. and Abel, T. and Meerlo, P.},
  title   = {{Sleep deprivation and hippocampal vulnerability: changes in neuronal plasticity, neurogenesis and cognitive function}},
  journal = {Neuroscience},
  year    = {2015},
  doi     = {10.1016/j.neuroscience.2015.04.053},
  pmid    = {25937398},
  url     = {https://doi.org/10.1016/j.neuroscience.2015.04.053}
}

@article{marsland2015-25882911,
  author  = {Marsland, A. L. and Gianaros, P. J. and Kuan, D. C. and Sheu, L. K. and Krajina, K. and Manuck, S. B.},
  title   = {{Brain morphology links systemic inflammation to cognitive function in midlife adults}},
  journal = {Brain, behavior, and immunity},
  year    = {2015},
  doi     = {10.1016/j.bbi.2015.03.015},
  pmid    = {25882911},
  url     = {https://doi.org/10.1016/j.bbi.2015.03.015}
}

@article{menkescaspi2015-25704951,
  author  = {Menkes-Caspi, N. and Yamin, H. G. and Kellner, V. and Spires-Jones, T. L. and Cohen, D. and Stern, E. A.},
  title   = {{Pathological tau disrupts ongoing network activity}},
  journal = {Neuron},
  year    = {2015},
  doi     = {10.1016/j.neuron.2015.01.025},
  pmid    = {25704951},
  url     = {https://doi.org/10.1016/j.neuron.2015.01.025}
}

@article{alleralvarez2017-25661268,
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  title   = {{Myoclonic epilepsy in Down syndrome and Alzheimer disease}},
  journal = {Neurologia (Barcelona, Spain)},
  year    = {2017},
  doi     = {10.1016/j.nrl.2014.12.008},
  pmid    = {25661268},
  url     = {https://doi.org/10.1016/j.nrl.2014.12.008}
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@article{sabogalguaqueta2015-25666032,
  author  = {Sabogal-Guáqueta, A. M. and Muñoz-Manco, J. I. and Ramírez-Pineda, JR. and Lamprea-Rodriguez, M. and Osorio, E. and Cardona-Gómez, G. P.},
  title   = {{The flavonoid quercetin ameliorates Alzheimer's disease pathology and protects cognitive and emotional function in aged triple transgenic Alzheimer's disease model mice}},
  journal = {Neuropharmacology},
  year    = {2015},
  doi     = {10.1016/j.neuropharm.2015.01.027},
  pmid    = {25666032},
  url     = {https://doi.org/10.1016/j.neuropharm.2015.01.027}
}

@article{witton2016-25480798,
  author  = {Witton, J. and Staniaszek, L. E. and Bartsch, U. and Randall, A. D. and Jones, M. W. and Brown, J. T.},
  title   = {{Disrupted hippocampal sharp-wave ripple-associated spike dynamics in a transgenic mouse model of dementia}},
  journal = {The Journal of physiology},
  year    = {2016},
  doi     = {10.1113/jphysiol.2014.282889},
  pmid    = {25480798},
  url     = {https://doi.org/10.1113/jphysiol.2014.282889}
}

@article{yang2015-26444086,
  author  = {Yang, P. and Pavlovic, D. and Waldvogel, H. and Dragunow, M. and Synek, B. and Turner, C. and Faull, R. and Guan, J.},
  title   = {{String Vessel Formation is Increased in the Brain of Parkinson Disease}},
  journal = {Journal of Parkinson's disease},
  year    = {2015},
  doi     = {10.3233/jpd-140454},
  pmid    = {26444086},
  url     = {https://doi.org/10.3233/jpd-140454}
}

@article{wang2015-25079798,
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  title   = {{Helicobacter pylori filtrate induces Alzheimer-like tau hyperphosphorylation by activating glycogen synthase kinase-3β}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2015},
  doi     = {10.3233/jad-140198},
  pmid    = {25079798},
  url     = {https://doi.org/10.3233/jad-140198}
}

@article{rubenstein2015-25177776,
  author  = {Rubenstein, R. and Chang, B. and Davies, P. and Wagner, A. K. and Robertson, C. S. and Wang, K. K.},
  title   = {{A novel, ultrasensitive assay for tau: potential for assessing traumatic brain injury in tissues and biofluids}},
  journal = {Journal of neurotrauma},
  year    = {2015},
  doi     = {10.1089/neu.2014.3548},
  pmid    = {25177776},
  url     = {https://doi.org/10.1089/neu.2014.3548}
}

@article{svensson2015-25527485,
  author  = {Svensson, M. and Lexell, J. and Deierborg, T.},
  title   = {{Effects of Physical Exercise on Neuroinflammation, Neuroplasticity, Neurodegeneration, and Behavior: What We Can Learn From Animal Models in Clinical Settings}},
  journal = {Neurorehabilitation and neural repair},
  year    = {2015},
  doi     = {10.1177/1545968314562108},
  pmid    = {25527485},
  url     = {https://doi.org/10.1177/1545968314562108}
}

@article{zhao2015-25352419,
  author  = {Zhao, Y. and Gong, C. X.},
  title   = {{From chronic cerebral hypoperfusion to Alzheimer-like brain pathology and neurodegeneration}},
  journal = {Cellular and molecular neurobiology},
  year    = {2015},
  doi     = {10.1007/s10571-014-0127-9},
  pmid    = {25352419},
  url     = {https://doi.org/10.1007/s10571-014-0127-9}
}

@article{lv2015-25261783,
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  title   = {{Multi-faced neuroprotective effects of geniposide depending on the RAGE-mediated signaling in an Alzheimer mouse model}},
  journal = {Neuropharmacology},
  year    = {2015},
  doi     = {10.1016/j.neuropharm.2014.09.019},
  pmid    = {25261783},
  url     = {https://doi.org/10.1016/j.neuropharm.2014.09.019}
}

@article{gorrie2014-25246588,
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  title   = {{Dendritic spinopathy in transgenic mice expressing ALS/dementia-linked mutant UBQLN2}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2014},
  doi     = {10.1073/pnas.1405741111},
  pmid    = {25246588},
  url     = {https://doi.org/10.1073/pnas.1405741111}
}

@article{liu2014-25242217,
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  title   = {{Deficiency in LRP6-mediated Wnt signaling contributes to synaptic abnormalities and amyloid pathology in Alzheimer's disease}},
  journal = {Neuron},
  year    = {2014},
  doi     = {10.1016/j.neuron.2014.08.048},
  pmid    = {25242217},
  url     = {https://doi.org/10.1016/j.neuron.2014.08.048}
}

@article{li2014-24977637,
  author  = {Li, C. and Liu, S. and Xing, Y. and Tao, F.},
  title   = {{The role of hippocampal tau protein phosphorylation in isoflurane-induced cognitive dysfunction in transgenic APP695 mice}},
  journal = {Anesthesia and analgesia},
  year    = {2014},
  doi     = {10.1213/ane.0000000000000315},
  pmid    = {24977637},
  url     = {https://doi.org/10.1213/ane.0000000000000315}
}

@article{opel2014-24924799,
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  title   = {{Hippocampal atrophy in major depression: a function of childhood maltreatment rather than diagnosis?}},
  journal = {Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology},
  year    = {2014},
  doi     = {10.1038/npp.2014.145},
  pmid    = {24924799},
  url     = {https://doi.org/10.1038/npp.2014.145}
}

@article{jiang2014-24880087,
  author  = {Jiang, T. and Yu, J. T. and Zhu, X. C. and Zhang, Q. Q. and Cao, L. and Wang, H. F. and Tan, M. S. and Gao, Q. and others},
  title   = {{Temsirolimus attenuates tauopathy in vitro and in vivo by targeting tau hyperphosphorylation and autophagic clearance}},
  journal = {Neuropharmacology},
  year    = {2014},
  doi     = {10.1016/j.neuropharm.2014.05.032},
  pmid    = {24880087},
  url     = {https://doi.org/10.1016/j.neuropharm.2014.05.032}
}

@article{andersson2014-24781550,
  author  = {Andersson, E. R. and Lendahl, U.},
  title   = {{Therapeutic modulation of Notch signalling--are we there yet?}},
  journal = {Nature reviews. Drug discovery},
  year    = {2014},
  doi     = {10.1038/nrd4252},
  pmid    = {24781550},
  url     = {https://doi.org/10.1038/nrd4252}
}

@article{liu2014-24468471,
  author  = {Liu, R. and Li, J. Z. and Song, J. K. and Zhou, D. and Huang, C. and Bai, X. Y. and Xie, T. and Zhang, X. and others},
  title   = {{Pinocembrin improves cognition and protects the neurovascular unit in Alzheimer related deficits}},
  journal = {Neurobiology of aging},
  year    = {2014},
  doi     = {10.1016/j.neurobiolaging.2013.12.031},
  pmid    = {24468471},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2013.12.031}
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@article{asuni2014-24366862,
  author  = {Asuni, A. A. and Gray, B. and Bailey, J. and Skipp, P. and Perry, V. H. and O'Connor, V.},
  title   = {{Analysis of the hippocampal proteome in ME7 prion disease reveals a predominant astrocytic signature and highlights the brain-restricted production of clusterin in chronic neurodegeneration}},
  journal = {The Journal of biological chemistry},
  year    = {2014},
  doi     = {10.1074/jbc.m113.502690},
  pmid    = {24366862},
  url     = {https://doi.org/10.1074/jbc.m113.502690}
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@article{patzke2015-24178679,
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  title   = {{In contrast to many other mammals, cetaceans have relatively small hippocampi that appear to lack adult neurogenesis}},
  journal = {Brain structure \& function},
  year    = {2015},
  doi     = {10.1007/s00429-013-0660-1},
  pmid    = {24178679},
  url     = {https://doi.org/10.1007/s00429-013-0660-1}
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@article{winston2013-23879560,
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  title   = {{Controlled cortical impact results in an extensive loss of dendritic spines that is not mediated by injury-induced amyloid-beta accumulation}},
  journal = {Journal of neurotrauma},
  year    = {2013},
  doi     = {10.1089/neu.2013.2960},
  pmid    = {23879560},
  url     = {https://doi.org/10.1089/neu.2013.2960}
}

@article{gu2013-24089520,
  author  = {Gu, J. and Congdon, E. E. and Sigurdsson, E. M.},
  title   = {{Two novel Tau antibodies targeting the 396/404 region are primarily taken up by neurons and reduce Tau protein pathology}},
  journal = {The Journal of biological chemistry},
  year    = {2013},
  doi     = {10.1074/jbc.m113.494922},
  pmid    = {24089520},
  url     = {https://doi.org/10.1074/jbc.m113.494922}
}

@article{teicher2013-23982148,
  author  = {Teicher, M. H. and Samson, J. A.},
  title   = {{Childhood maltreatment and psychopathology: A case for ecophenotypic variants as clinically and neurobiologically distinct subtypes}},
  journal = {The American journal of psychiatry},
  year    = {2013},
  doi     = {10.1176/appi.ajp.2013.12070957},
  pmid    = {23982148},
  url     = {https://doi.org/10.1176/appi.ajp.2013.12070957}
}

@article{tiribuzi2014-24064186,
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  title   = {{miR128 up-regulation correlates with impaired amyloid β(1-42) degradation in monocytes from patients with sporadic Alzheimer's disease}},
  journal = {Neurobiology of aging},
  year    = {2014},
  doi     = {10.1016/j.neurobiolaging.2013.08.003},
  pmid    = {24064186},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2013.08.003}
}

@article{zhang2014-24022672,
  author  = {Zhang, Z. and Liu, X. and Schroeder, J. P. and Chan, C. B. and Song, M. and Yu, S. P. and Weinshenker, D. and Ye, K.},
  title   = {{7,8-dihydroxyflavone prevents synaptic loss and memory deficits in a mouse model of Alzheimer's disease}},
  journal = {Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology},
  year    = {2014},
  doi     = {10.1038/npp.2013.243},
  pmid    = {24022672},
  url     = {https://doi.org/10.1038/npp.2013.243}
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@article{soleman2013-24012743,
  author  = {Soleman, S. and Filippov, M. A. and Dityatev, A. and Fawcett, J. W.},
  title   = {{Targeting the neural extracellular matrix in neurological disorders}},
  journal = {Neuroscience},
  year    = {2013},
  doi     = {10.1016/j.neuroscience.2013.08.050},
  pmid    = {24012743},
  url     = {https://doi.org/10.1016/j.neuroscience.2013.08.050}
}

@article{ew2013-24048854,
  author  = {ÉW, Griffin and Skelly, D. T. and Murray, C. L. and Cunningham, C.},
  title   = {{Cyclooxygenase-1-dependent prostaglandins mediate susceptibility to systemic inflammation-induced acute cognitive dysfunction}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2013},
  doi     = {10.1523/jneurosci.6361-11.2013},
  pmid    = {24048854},
  url     = {https://doi.org/10.1523/jneurosci.6361-11.2013}
}

@article{bihaqi2013-23973560,
  author  = {Bihaqi, S. W. and Zawia, N. H.},
  title   = {{Enhanced taupathy and AD-like pathology in aged primate brains decades after infantile exposure to lead (Pb)}},
  journal = {Neurotoxicology},
  year    = {2013},
  doi     = {10.1016/j.neuro.2013.07.010},
  pmid    = {23973560},
  url     = {https://doi.org/10.1016/j.neuro.2013.07.010}
}

@article{parihar2013-23807240,
  author  = {Parihar, V. K. and Hattiangady, B. and Shuai, B. and Shetty, A. K.},
  title   = {{Mood and memory deficits in a model of Gulf War illness are linked with reduced neurogenesis, partial neuron loss, and mild inflammation in the hippocampus}},
  journal = {Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology},
  year    = {2013},
  doi     = {10.1038/npp.2013.158},
  pmid    = {23807240},
  url     = {https://doi.org/10.1038/npp.2013.158}
}

@article{balu2013-23729812,
  author  = {Balu, D. T. and Li, Y. and Puhl, M. D. and Benneyworth, M. A. and Basu, A. C. and Takagi, S. and Bolshakov, V. Y. and Coyle, J. T.},
  title   = {{Multiple risk pathways for schizophrenia converge in serine racemase knockout mice, a mouse model of NMDA receptor hypofunction}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2013},
  doi     = {10.1073/pnas.1304308110},
  pmid    = {23729812},
  url     = {https://doi.org/10.1073/pnas.1304308110}
}

@article{alexandrov2013-23778113,
  author  = {Alexandrov, P. N. and Zhao, Y. and Jones, B. M. and Bhattacharjee, S. and Lukiw, W. J.},
  title   = {{Expression of the phagocytosis-essential protein TREM2 is down-regulated by an aluminum-induced miRNA-34a in a murine microglial cell line}},
  journal = {Journal of inorganic biochemistry},
  year    = {2013},
  doi     = {10.1016/j.jinorgbio.2013.05.010},
  pmid    = {23778113},
  url     = {https://doi.org/10.1016/j.jinorgbio.2013.05.010}
}

@article{lu2013-23674053,
  author  = {Lu, B. and Nagappan, G. and Guan, X. and Nathan, P. J. and Wren, P.},
  title   = {{BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases}},
  journal = {Nature reviews. Neuroscience},
  year    = {2013},
  doi     = {10.1038/nrn3505},
  pmid    = {23674053},
  url     = {https://doi.org/10.1038/nrn3505}
}

@article{hawkins2013-23632019,
  author  = {Hawkins, B. E. and Krishnamurthy, S. and Castillo-Carranza, D. L. and Sengupta, U. and Prough, D. S. and Jackson, G. R. and DeWitt, D. S. and Kayed, R.},
  title   = {{Rapid accumulation of endogenous tau oligomers in a rat model of traumatic brain injury: possible link between traumatic brain injury and sporadic tauopathies}},
  journal = {The Journal of biological chemistry},
  year    = {2013},
  doi     = {10.1074/jbc.m113.472746},
  pmid    = {23632019},
  url     = {https://doi.org/10.1074/jbc.m113.472746}
}

@article{sahm2013-23548271,
  author  = {Sahm, F. and Oezen, I. and Opitz, C. A. and Radlwimmer, B. and von Deimling, A. and Ahrendt, T. and Adams, S. and Bode, H. B. and others},
  title   = {{The endogenous tryptophan metabolite and NAD+ precursor quinolinic acid confers resistance of gliomas to oxidative stress}},
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@article{mohler2012-22898099,
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@article{niblock2012-22817715,
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  title   = {{Inhibition of tau aggregation in a novel Caenorhabditis elegans model of tauopathy mitigates proteotoxicity}},
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@article{deak2012-22503992,
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  title   = {{Dantrolene ameliorates cognitive decline and neuropathology in Alzheimer triple transgenic mice}},
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@article{congdon2012-22361619,
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  title   = {{Methylthioninium chloride (methylene blue) induces autophagy and attenuates tauopathy in vitro and in vivo}},
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@article{capone2012-22492044,
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  title   = {{Central cardiovascular circuits contribute to the neurovascular dysfunction in angiotensin II hypertension}},
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  title   = {{Abnormalities in hippocampal functioning with persistent pain}},
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@article{ono2012-22393064,
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  title   = {{Phenolic compounds prevent amyloid β-protein oligomerization and synaptic dysfunction by site-specific binding}},
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@article{tran2012-22249463,
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  title   = {{Endogenous TDP-43 localized to stress granules can subsequently form protein aggregates}},
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  title   = {{Hyperphosphorylated Tau in an α-synuclein-overexpressing transgenic model of Parkinson's disease}},
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  title   = {{The neuronal transporter gene SLC6A15 confers risk to major depression}},
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@article{guo2011-21372138,
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@article{murakami2011-21558647,
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  title   = {{Vitamin C restores behavioral deficits and amyloid-β oligomerization without affecting plaque formation in a mouse model of Alzheimer's disease}},
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@article{chen2011-21164132,
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  title   = {{Diminished gray matter in the hippocampus of cannabis users: possible protective effects of cannabidiol}},
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  year    = {2011},
  doi     = {10.1016/j.drugalcdep.2010.09.020},
  pmid    = {21050680},
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}

@article{takata2010-20947502,
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  title   = {{Galantamine-induced amyloid-beta clearance mediated via stimulation of microglial nicotinic acetylcholine receptors}},
  journal = {The Journal of biological chemistry},
  year    = {2010},
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  pmid    = {20947502},
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}

@article{kimura2010-20921222,
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  title   = {{Aggregation of detergent-insoluble tau is involved in neuronal loss but not in synaptic loss}},
  journal = {The Journal of biological chemistry},
  year    = {2010},
  doi     = {10.1074/jbc.m110.136630},
  pmid    = {20921222},
  url     = {https://doi.org/10.1074/jbc.m110.136630}
}

@article{silverberg2010-20838242,
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  title   = {{Amyloid efflux transporter expression at the blood-brain barrier declines in normal aging}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2010},
  doi     = {10.1097/nen.0b013e3181f46e25},
  pmid    = {20838242},
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}

@article{dineley2010-20544830,
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  title   = {{Amyloid-beta oligomers impair fear conditioned memory in a calcineurin-dependent fashion in mice}},
  journal = {Journal of neuroscience research},
  year    = {2010},
  doi     = {10.1002/jnr.22445},
  pmid    = {20544830},
  url     = {https://doi.org/10.1002/jnr.22445}
}

@article{inoue2010-20832055,
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  title   = {{Association between the oxytocin receptor gene and amygdalar volume in healthy adults}},
  journal = {Biological psychiatry},
  year    = {2010},
  doi     = {10.1016/j.biopsych.2010.07.019},
  pmid    = {20832055},
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}

@article{behrens2010-20683840,
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  title   = {{Clinical spectrum of Kufor-Rakeb syndrome in the Chilean kindred with ATP13A2 mutations}},
  journal = {Movement disorders : official journal of the Movement Disorder Society},
  year    = {2010},
  doi     = {10.1002/mds.22996},
  pmid    = {20683840},
  url     = {https://doi.org/10.1002/mds.22996}
}

@article{steinert2010-20817920,
  author  = {Steinert, JR. and Chernova, T. and Forsythe, I. D.},
  title   = {{Nitric oxide signaling in brain function, dysfunction, and dementia}},
  journal = {The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry},
  year    = {2010},
  doi     = {10.1177/1073858410366481},
  pmid    = {20817920},
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}

@article{guglielmotto2012-20638753,
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  title   = {{AGEs/RAGE complex upregulates BACE1 via NF-κB pathway activation}},
  journal = {Neurobiology of aging},
  year    = {2012},
  doi     = {10.1016/j.neurobiolaging.2010.05.026},
  pmid    = {20638753},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2010.05.026}
}

@article{hampton2010-20668182,
  author  = {Hampton, D. W. and Webber, D. J. and Bilican, B. and Goedert, M. and Spillantini, M. G. and Chandran, S.},
  title   = {{Cell-mediated neuroprotection in a mouse model of human tauopathy}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2010},
  doi     = {10.1523/jneurosci.0834-10.2010},
  pmid    = {20668182},
  url     = {https://doi.org/10.1523/jneurosci.0834-10.2010}
}

@article{noonan2010-19580383,
  author  = {Noonan, K. A. and Jefferies, E. and Corbett, F. and Lambon Ralph, M. A.},
  title   = {{Elucidating the nature of deregulated semantic cognition in semantic aphasia: evidence for the roles of prefrontal and temporo-parietal cortices}},
  journal = {Journal of cognitive neuroscience},
  year    = {2010},
  doi     = {10.1162/jocn.2009.21289},
  pmid    = {19580383},
  url     = {https://doi.org/10.1162/jocn.2009.21289}
}

@article{wills2010-20599975,
  author  = {Wills, J. and Jones, J. and Haggerty, T. and Duka, V. and Joyce, J. N. and Sidhu, A.},
  title   = {{Elevated tauopathy and alpha-synuclein pathology in postmortem Parkinson's disease brains with and without dementia}},
  journal = {Experimental neurology},
  year    = {2010},
  doi     = {10.1016/j.expneurol.2010.06.017},
  pmid    = {20599975},
  url     = {https://doi.org/10.1016/j.expneurol.2010.06.017}
}

@article{scott2010-20554859,
  author  = {Scott, D. A. and Tabarean, I. and Tang, Y. and Cartier, A. and Masliah, E. and Roy, S.},
  title   = {{A pathologic cascade leading to synaptic dysfunction in alpha-synuclein-induced neurodegeneration}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2010},
  doi     = {10.1523/jneurosci.1091-10.2010},
  pmid    = {20554859},
  url     = {https://doi.org/10.1523/jneurosci.1091-10.2010}
}

@article{zong2010-20504772,
  author  = {Zong, H. and Madden, A. and Ward, M. and Mooney, M. H. and Elliott, C. T. and Stitt, A. W.},
  title   = {{Homodimerization is essential for the receptor for advanced glycation end products (RAGE)-mediated signal transduction}},
  journal = {The Journal of biological chemistry},
  year    = {2010},
  doi     = {10.1074/jbc.m110.133827},
  pmid    = {20504772},
  url     = {https://doi.org/10.1074/jbc.m110.133827}
}

@article{bamburg2010-20088812,
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  title   = {{ADF/Cofilin-actin rods in neurodegenerative diseases}},
  journal = {Current Alzheimer research},
  year    = {2010},
  doi     = {10.2174/156720510791050902},
  pmid    = {20088812},
  url     = {https://doi.org/10.2174/156720510791050902}
}

@article{nordanskog2010-20190603,
  author  = {Nordanskog, P. and Dahlstrand, U. and Larsson, M. R. and Larsson, E. M. and Knutsson, L. and Johanson, A.},
  title   = {{Increase in hippocampal volume after electroconvulsive therapy in patients with depression: a volumetric magnetic resonance imaging study}},
  journal = {The journal of ECT},
  year    = {2010},
  doi     = {10.1097/yct.0b013e3181a95da8},
  pmid    = {20190603},
  url     = {https://doi.org/10.1097/yct.0b013e3181a95da8}
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@article{vance2010-20170744,
  author  = {Vance, J. E. and Hayashi, H.},
  title   = {{Formation and function of apolipoprotein E-containing lipoproteins in the nervous system}},
  journal = {Biochimica et biophysica acta},
  year    = {2010},
  doi     = {10.1016/j.bbalip.2010.02.007},
  pmid    = {20170744},
  url     = {https://doi.org/10.1016/j.bbalip.2010.02.007}
}

@article{mondelli2010-20071148,
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  title   = {{Higher cortisol levels are associated with smaller left hippocampal volume in first-episode psychosis}},
  journal = {Schizophrenia research},
  year    = {2010},
  doi     = {10.1016/j.schres.2009.12.021},
  pmid    = {20071148},
  url     = {https://doi.org/10.1016/j.schres.2009.12.021}
}

@article{ueno2010-20175745,
  author  = {Ueno, M. and Nakagawa, T. and Wu, B. and Onodera, M. and Huang, C. L. and Kusaka, T. and Araki, N. and Sakamoto, H.},
  title   = {{Transporters in the brain endothelial barrier}},
  journal = {Current medicinal chemistry},
  year    = {2010},
  doi     = {10.2174/092986710790827816},
  pmid    = {20175745},
  url     = {https://doi.org/10.2174/092986710790827816}
}

@article{heckers2010-21312412,
  author  = {Heckers, S. and Konradi, C.},
  title   = {{Hippocampal pathology in schizophrenia}},
  journal = {Current topics in behavioral neurosciences},
  year    = {2010},
  doi     = {10.1007/7854_2010_43},
  pmid    = {21312412},
  url     = {https://doi.org/10.1007/7854_2010_43}
}

@article{zhao2010-20032460,
  author  = {Zhao, W. Q. and Santini, F. and Breese, R. and Ross, D. and Zhang, X. D. and Stone, D. J. and Ferrer, M. and Townsend, M. and others},
  title   = {{Inhibition of calcineurin-mediated endocytosis and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors prevents amyloid beta oligomer-induced synaptic disruption}},
  journal = {The Journal of biological chemistry},
  year    = {2010},
  doi     = {10.1074/jbc.m109.057182},
  pmid    = {20032460},
  url     = {https://doi.org/10.1074/jbc.m109.057182}
}

@article{calabrese2009-19558211,
  author  = {Calabrese, V. and Cornelius, C. and Rizzarelli, E. and Owen, J. B. and Dinkova-Kostova, A. T. and Butterfield, D. A.},
  title   = {{Nitric oxide in cell survival: a janus molecule}},
  journal = {Antioxidants \& redox signaling},
  year    = {2009},
  doi     = {10.1089/ars.2009.2721},
  pmid    = {19558211},
  url     = {https://doi.org/10.1089/ars.2009.2721}
}

@article{whiteman2009-19828813,
  author  = {Whiteman, I. T. and Gervasio, O. L. and Cullen, K. M. and Guillemin, G. J. and Jeong, E. V. and Witting, P. K. and Antao, S. T. and Minamide, L. S. and others},
  title   = {{Activated actin-depolymerizing factor/cofilin sequesters phosphorylated microtubule-associated protein during the assembly of alzheimer-like neuritic cytoskeletal striations}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2009},
  doi     = {10.1523/jneurosci.3531-09.2009},
  pmid    = {19828813},
  url     = {https://doi.org/10.1523/jneurosci.3531-09.2009}
}

@article{waxman2009-19722699,
  author  = {Waxman, E. A. and Mazzulli, JR. and Giasson, B. I.},
  title   = {{Characterization of hydrophobic residue requirements for alpha-synuclein fibrillization}},
  journal = {Biochemistry},
  year    = {2009},
  doi     = {10.1021/bi900539p},
  pmid    = {19722699},
  url     = {https://doi.org/10.1021/bi900539p}
}

@article{tata2010-19786041,
  author  = {Tata, D. A. and Anderson, B. J.},
  title   = {{The effects of chronic glucocorticoid exposure on dendritic length, synapse numbers and glial volume in animal models: implications for hippocampal volume reductions in depression}},
  journal = {Physiology \& behavior},
  year    = {2010},
  doi     = {10.1016/j.physbeh.2009.09.008},
  pmid    = {19786041},
  url     = {https://doi.org/10.1016/j.physbeh.2009.09.008}
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@article{wang2009-19654187,
  author  = {Wang, Y. and Martinez-Vicente, M. and Krüger, U. and Kaushik, S. and Wong, E. and Mandelkow, E. M. and Cuervo, A. M. and Mandelkow, E.},
  title   = {{Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing}},
  journal = {Human molecular genetics},
  year    = {2009},
  doi     = {10.1093/hmg/ddp367},
  pmid    = {19654187},
  url     = {https://doi.org/10.1093/hmg/ddp367}
}

@article{decalignon2009-19535996,
  author  = {de Calignon, A. and Spires-Jones, T. L. and Pitstick, R. and Carlson, G. A. and Hyman, B. T.},
  title   = {{Tangle-bearing neurons survive despite disruption of membrane integrity in a mouse model of tauopathy}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2009},
  doi     = {10.1097/nen.0b013e3181a9fc66},
  pmid    = {19535996},
  url     = {https://doi.org/10.1097/nen.0b013e3181a9fc66}
}

@article{schlenzig2009-19518051,
  author  = {Schlenzig, D. and Manhart, S. and Cinar, Y. and Kleinschmidt, M. and Hause, G. and Willbold, D. and Funke, S. A. and Schilling, S. and others},
  title   = {{Pyroglutamate formation influences solubility and amyloidogenicity of amyloid peptides}},
  journal = {Biochemistry},
  year    = {2009},
  doi     = {10.1021/bi900818a},
  pmid    = {19518051},
  url     = {https://doi.org/10.1021/bi900818a}
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@article{poon2011-19540623,
  author  = {Poon, W. W. and Blurton-Jones, M. and Tu, C. H. and Feinberg, L. M. and Chabrier, M. A. and Harris, J. W. and Jeon, N. L. and Cotman, C. W.},
  title   = {{β-Amyloid impairs axonal BDNF retrograde trafficking}},
  journal = {Neurobiology of aging},
  year    = {2011},
  doi     = {10.1016/j.neurobiolaging.2009.05.012},
  pmid    = {19540623},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2009.05.012}
}

@article{study2009-19647672,
  author  = {{NP-C Guidelines Working Group} and Wraith, J. E. and Baumgartner, M. R. and Bembi, B. and Covanis, A. and Levade, T. and Mengel, E. and Pineda, M. and others},
  title   = {{Recommendations on the diagnosis and management of Niemann-Pick disease type C}},
  journal = {Molecular genetics and metabolism},
  year    = {2009},
  doi     = {10.1016/j.ymgme.2009.06.008},
  pmid    = {19647672},
  url     = {https://doi.org/10.1016/j.ymgme.2009.06.008}
}

@article{yuede2009-19524672,
  author  = {Yuede, C. M. and Zimmerman, S. D. and Dong, H. and Kling, M. J. and Bero, A. W. and Holtzman, D. M. and Timson, B. F. and Csernansky, J. G.},
  title   = {{Effects of voluntary and forced exercise on plaque deposition, hippocampal volume, and behavior in the Tg2576 mouse model of Alzheimer's disease}},
  journal = {Neurobiology of disease},
  year    = {2009},
  doi     = {10.1016/j.nbd.2009.06.002},
  pmid    = {19524672},
  url     = {https://doi.org/10.1016/j.nbd.2009.06.002}
}

@article{ohmi2009-19416848,
  author  = {Ohmi, K. and Kudo, L. C. and Ryazantsev, S. and Zhao, H. Z. and Karsten, S. L. and Neufeld, E. F.},
  title   = {{Sanfilippo syndrome type B, a lysosomal storage disease, is also a tauopathy}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2009},
  doi     = {10.1073/pnas.0903223106},
  pmid    = {19416848},
  url     = {https://doi.org/10.1073/pnas.0903223106}
}

@article{li2009-19380826,
  author  = {Li, M. and Shang, D. S. and Zhao, W. D. and Tian, L. and Li, B. and Fang, W. G. and Zhu, L. and Man, S. M. and others},
  title   = {{Amyloid beta interaction with receptor for advanced glycation end products up-regulates brain endothelial CCR5 expression and promotes T cells crossing the blood-brain barrier}},
  journal = {Journal of immunology (Baltimore, Md. : 1950)},
  year    = {2009},
  doi     = {10.4049/jimmunol.0803013},
  pmid    = {19380826},
  url     = {https://doi.org/10.4049/jimmunol.0803013}
}

@article{zhao2009-19406747,
  author  = {Zhao, W. Q. and Lacor, P. N. and Chen, H. and Lambert, M. P. and Quon, M. J. and Krafft, G. A. and Klein, W. L.},
  title   = {{Insulin receptor dysfunction impairs cellular clearance of neurotoxic oligomeric abeta}},
  journal = {The Journal of biological chemistry},
  year    = {2009},
  doi     = {10.1074/jbc.m109.011015},
  pmid    = {19406747},
  url     = {https://doi.org/10.1074/jbc.m109.011015}
}

@article{paquet2009-19363289,
  author  = {Paquet, D. and Bhat, R. and Sydow, A. and Mandelkow, E. M. and Berg, S. and Hellberg, S. and Fälting, J. and Distel, M. and others},
  title   = {{A zebrafish model of tauopathy allows in vivo imaging of neuronal cell death and drug evaluation}},
  journal = {The Journal of clinical investigation},
  year    = {2009},
  doi     = {10.1172/jci37537},
  pmid    = {19363289},
  url     = {https://doi.org/10.1172/jci37537}
}

@article{du2011-19362755,
  author  = {Du, H. and Guo, L. and Zhang, W. and Rydzewska, M. and Yan, S.},
  title   = {{Cyclophilin D deficiency improves mitochondrial function and learning/memory in aging Alzheimer disease mouse model}},
  journal = {Neurobiology of aging},
  year    = {2011},
  doi     = {10.1016/j.neurobiolaging.2009.03.003},
  pmid    = {19362755},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2009.03.003}
}

@article{savitz2009-19358877,
  author  = {Savitz, J. B. and Drevets, W. C.},
  title   = {{Imaging phenotypes of major depressive disorder: genetic correlates}},
  journal = {Neuroscience},
  year    = {2009},
  doi     = {10.1016/j.neuroscience.2009.03.082},
  pmid    = {19358877},
  url     = {https://doi.org/10.1016/j.neuroscience.2009.03.082}
}

@article{montag2009-19335934,
  author  = {Montag, C. and Weber, B. and Fliessbach, K. and Elger, C. and Reuter, M.},
  title   = {{The BDNF Val66Met polymorphism impacts parahippocampal and amygdala volume in healthy humans: incremental support for a genetic risk factor for depression}},
  journal = {Psychological medicine},
  year    = {2009},
  doi     = {10.1017/s0033291709005509},
  pmid    = {19335934},
  url     = {https://doi.org/10.1017/s0033291709005509}
}

@article{yu2009-19339601,
  author  = {Yu, H. and Wang, Y. and Pattwell, S. and Jing, D. and Liu, T. and Zhang, Y. and Bath, K. G. and Lee, F. S. and others},
  title   = {{Variant BDNF Val66Met polymorphism affects extinction of conditioned aversive memory}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2009},
  doi     = {10.1523/jneurosci.5539-08.2009},
  pmid    = {19339601},
  url     = {https://doi.org/10.1523/jneurosci.5539-08.2009}
}

@article{veena2009-19429116,
  author  = {Veena, J. and Srikumar, B. N. and Raju, T. R. and Shankaranarayana Rao, B. S.},
  title   = {{Exposure to enriched environment restores the survival and differentiation of new born cells in the hippocampus and ameliorates depressive symptoms in chronically stressed rats}},
  journal = {Neuroscience letters},
  year    = {2009},
  doi     = {10.1016/j.neulet.2009.03.059},
  pmid    = {19429116},
  url     = {https://doi.org/10.1016/j.neulet.2009.03.059}
}

@article{veena2009-19006089,
  author  = {Veena, J. and Srikumar, B. N. and Mahati, K. and Bhagya, V. and Raju, T. R. and Shankaranarayana Rao, B. S.},
  title   = {{Enriched environment restores hippocampal cell proliferation and ameliorates cognitive deficits in chronically stressed rats}},
  journal = {Journal of neuroscience research},
  year    = {2009},
  doi     = {10.1002/jnr.21907},
  pmid    = {19006089},
  url     = {https://doi.org/10.1002/jnr.21907}
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@article{terni2010-19298596,
  author  = {Terni, B. and Boada, J. and Portero-Otin, M. and Pamplona, R. and Ferrer, I.},
  title   = {{Mitochondrial ATP-synthase in the entorhinal cortex is a target of oxidative stress at stages I/II of Alzheimer's disease pathology}},
  journal = {Brain pathology (Zurich, Switzerland)},
  year    = {2010},
  doi     = {10.1111/j.1750-3639.2009.00266.x},
  pmid    = {19298596},
  url     = {https://doi.org/10.1111/j.1750-3639.2009.00266.x}
}

@article{torner2009-19211889,
  author  = {Torner, L. and Karg, S. and Blume, A. and Kandasamy, M. and Kuhn, H. G. and Winkler, J. and Aigner, L. and Neumann, I. D.},
  title   = {{Prolactin prevents chronic stress-induced decrease of adult hippocampal neurogenesis and promotes neuronal fate}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2009},
  doi     = {10.1523/jneurosci.3178-08.2009},
  pmid    = {19211889},
  url     = {https://doi.org/10.1523/jneurosci.3178-08.2009}
}

@article{tchantchou2009-19661619,
  author  = {Tchantchou, F. and Lacor, P. N. and Cao, Z. and Lao, L. and Hou, Y. and Cui, C. and Klein, W. L. and Luo, Y.},
  title   = {{Stimulation of neurogenesis and synaptogenesis by bilobalide and quercetin via common final pathway in hippocampal neurons}},
  journal = {Journal of Alzheimer's disease : JAD},
  year    = {2009},
  doi     = {10.3233/jad-2009-1189},
  pmid    = {19661619},
  url     = {https://doi.org/10.3233/jad-2009-1189}
}

@article{vankasteren2009-19106304,
  author  = {van Kasteren, S. I. and Campbell, S. J. and Serres, S. and Anthony, D. C. and Sibson, N. R. and Davis, B. G.},
  title   = {{Glyconanoparticles allow pre-symptomatic in vivo imaging of brain disease}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2009},
  doi     = {10.1073/pnas.0806787106},
  pmid    = {19106304},
  url     = {https://doi.org/10.1073/pnas.0806787106}
}

@article{jicha2010-19026468,
  author  = {Jicha, G. A. and Schmitt, F. A. and Abner, E. and Nelson, P. T. and Cooper, G. E. and Smith, C. D. and Markesbery, W. R.},
  title   = {{Prodromal clinical manifestations of neuropathologically confirmed Lewy body disease}},
  journal = {Neurobiology of aging},
  year    = {2010},
  doi     = {10.1016/j.neurobiolaging.2008.09.017},
  pmid    = {19026468},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2008.09.017}
}

@article{venna2009-18848400,
  author  = {Venna, V. R. and Deplanque, D. and Allet, C. and Belarbi, K. and Hamdane, M. and Bordet, R.},
  title   = {{PUFA induce antidepressant-like effects in parallel to structural and molecular changes in the hippocampus}},
  journal = {Psychoneuroendocrinology},
  year    = {2009},
  doi     = {10.1016/j.psyneuen.2008.08.025},
  pmid    = {18848400},
  url     = {https://doi.org/10.1016/j.psyneuen.2008.08.025}
}

@article{kovacs2008-18800011,
  author  = {Kovacs, G. G. and Majtenyi, K. and Spina, S. and Murrell, JR. and Gelpi, E. and Hoftberger, R. and Fraser, G. and Crowther, R. A. and others},
  title   = {{White matter tauopathy with globular glial inclusions: a distinct sporadic frontotemporal lobar degeneration}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2008},
  doi     = {10.1097/nen.0b013e318187a80f},
  pmid    = {18800011},
  url     = {https://doi.org/10.1097/nen.0b013e318187a80f}
}

@article{reese2008-18782350,
  author  = {Reese, L. C. and Zhang, W. and Dineley, K. T. and Kayed, R. and Taglialatela, G.},
  title   = {{Selective induction of calcineurin activity and signaling by oligomeric amyloid beta}},
  journal = {Aging cell},
  year    = {2008},
  doi     = {10.1111/j.1474-9726.2008.00434.x},
  pmid    = {18782350},
  url     = {https://doi.org/10.1111/j.1474-9726.2008.00434.x}
}

@article{staropoli2008-18623069,
  author  = {Staropoli, J. F.},
  title   = {{Tumorigenesis and neurodegeneration: two sides of the same coin?}},
  journal = {BioEssays : news and reviews in molecular, cellular and developmental biology},
  year    = {2008},
  doi     = {10.1002/bies.20784},
  pmid    = {18623069},
  url     = {https://doi.org/10.1002/bies.20784}
}

@article{heim2008-18602762,
  author  = {Heim, C. and Newport, D. J. and Mletzko, T. and Miller, A. H. and Nemeroff, C. B.},
  title   = {{The link between childhood trauma and depression: insights from HPA axis studies in humans}},
  journal = {Psychoneuroendocrinology},
  year    = {2008},
  doi     = {10.1016/j.psyneuen.2008.03.008},
  pmid    = {18602762},
  url     = {https://doi.org/10.1016/j.psyneuen.2008.03.008}
}

@article{hwang2008-18639562,
  author  = {Hwang, J. and Zheng, L. T. and Ock, J. and Lee, M. G. and Kim, S. H. and Lee, H. W. and Lee, W. H. and Park, H. C. and others},
  title   = {{Inhibition of glial inflammatory activation and neurotoxicity by tricyclic antidepressants}},
  journal = {Neuropharmacology},
  year    = {2008},
  doi     = {10.1016/j.neuropharm.2008.06.045},
  pmid    = {18639562},
  url     = {https://doi.org/10.1016/j.neuropharm.2008.06.045}
}

@article{jin2008-18483410,
  author  = {Jin, S. and Hansson, E. M. and Tikka, S. and Lanner, F. and Sahlgren, C. and Farnebo, F. and Baumann, M. and Kalimo, H. and others},
  title   = {{Notch signaling regulates platelet-derived growth factor receptor-beta expression in vascular smooth muscle cells}},
  journal = {Circulation research},
  year    = {2008},
  doi     = {10.1161/circresaha.107.167965},
  pmid    = {18483410},
  url     = {https://doi.org/10.1161/circresaha.107.167965}
}

@article{lim2008-18431510,
  author  = {Lim, J. and Balastik, M. and Lee, T. H. and Nakamura, K. and Liou, Y. C. and Sun, A. and Finn, G. and Pastorino, L. and others},
  title   = {{Pin1 has opposite effects on wild-type and P301L tau stability and tauopathy}},
  journal = {The Journal of clinical investigation},
  year    = {2008},
  doi     = {10.1172/jci34308},
  pmid    = {18431510},
  url     = {https://doi.org/10.1172/jci34308}
}

@article{boeve2008-18413467,
  author  = {Boeve, B. F. and Hutton, M.},
  title   = {{Refining frontotemporal dementia with parkinsonism linked to chromosome 17: introducing FTDP-17 (MAPT) and FTDP-17 (PGRN)}},
  journal = {Archives of neurology},
  year    = {2008},
  doi     = {10.1001/archneur.65.4.460},
  pmid    = {18413467},
  url     = {https://doi.org/10.1001/archneur.65.4.460}
}

@article{lodygensky2008-18356754,
  author  = {Lodygensky, G. A. and Seghier, M. L. and Warfield, S. K. and Tolsa, C. B. and Sizonenko, S. and Lazeyras, F. and Hüppi, P. S.},
  title   = {{Intrauterine growth restriction affects the preterm infant's hippocampus}},
  journal = {Pediatric research},
  year    = {2008},
  doi     = {10.1203/pdr.0b013e318165c005},
  pmid    = {18356754},
  url     = {https://doi.org/10.1203/pdr.0b013e318165c005}
}

@article{rosenmann2008-18490011,
  author  = {Rosenmann, H. and Grigoriadis, N. and Eldar-Levy, H. and Avital, A. and Rozenstein, L. and Touloumi, O. and Behar, L. and Ben-Hur, T. and others},
  title   = {{A novel transgenic mouse expressing double mutant tau driven by its natural promoter exhibits tauopathy characteristics}},
  journal = {Experimental neurology},
  year    = {2008},
  doi     = {10.1016/j.expneurol.2008.03.007},
  pmid    = {18490011},
  url     = {https://doi.org/10.1016/j.expneurol.2008.03.007}
}

@article{lee2008-18326497,
  author  = {Lee, S. G. and Su, Z. Z. and Emdad, L. and Gupta, P. and Sarkar, D. and Borjabad, A. and Volsky, D. J. and Fisher, P. B.},
  title   = {{Mechanism of ceftriaxone induction of excitatory amino acid transporter-2 expression and glutamate uptake in primary human astrocytes}},
  journal = {The Journal of biological chemistry},
  year    = {2008},
  doi     = {10.1074/jbc.m707697200},
  pmid    = {18326497},
  url     = {https://doi.org/10.1074/jbc.m707697200}
}

@article{murray2008-18289522,
  author  = {Murray, F. and Smith, D. W. and Hutson, P. H.},
  title   = {{Chronic low dose corticosterone exposure decreased hippocampal cell proliferation, volume and induced anxiety and depression like behaviours in mice}},
  journal = {European journal of pharmacology},
  year    = {2008},
  doi     = {10.1016/j.ejphar.2008.01.014},
  pmid    = {18289522},
  url     = {https://doi.org/10.1016/j.ejphar.2008.01.014}
}

@article{zheng2008-18279803,
  author  = {Zheng, L. T. and Ock, J. and Kwon, B. M. and Suk, K.},
  title   = {{Suppressive effects of flavonoid fisetin on lipopolysaccharide-induced microglial activation and neurotoxicity}},
  journal = {International immunopharmacology},
  year    = {2008},
  doi     = {10.1016/j.intimp.2007.12.012},
  pmid    = {18279803},
  url     = {https://doi.org/10.1016/j.intimp.2007.12.012}
}

@article{mocanu2008-18199773,
  author  = {Mocanu, M. M. and Nissen, A. and Eckermann, K. and Khlistunova, I. and Biernat, J. and Drexler, D. and Petrova, O. and Schönig, K. and others},
  title   = {{The potential for beta-structure in the repeat domain of tau protein determines aggregation, synaptic decay, neuronal loss, and coassembly with endogenous Tau in inducible mouse models of tauopathy}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2008},
  doi     = {10.1523/jneurosci.2824-07.2008},
  pmid    = {18199773},
  url     = {https://doi.org/10.1523/jneurosci.2824-07.2008}
}

@article{sedaghat2008-19158963,
  author  = {Sedaghat, F. and Notopoulos, A.},
  title   = {{S100 protein family and its application in clinical practice}},
  journal = {Hippokratia},
  year    = {2008},
  pmid    = {19158963}
}

@article{andersen2008-18806232,
  author  = {Andersen, S. L. and Tomada, A. and Vincow, E. S. and Valente, E. and Polcari, A. and Teicher, M. H.},
  title   = {{Preliminary evidence for sensitive periods in the effect of childhood sexual abuse on regional brain development}},
  journal = {The Journal of neuropsychiatry and clinical neurosciences},
  year    = {2008},
  doi     = {10.1176/jnp.2008.20.3.292},
  pmid    = {18806232},
  url     = {https://doi.org/10.1176/jnp.2008.20.3.292}
}

@article{bremner2008-18037014,
  author  = {Bremner, J. D. and Elzinga, B. and Schmahl, C. and Vermetten, E.},
  title   = {{Structural and functional plasticity of the human brain in posttraumatic stress disorder}},
  journal = {Progress in brain research},
  year    = {2008},
  doi     = {10.1016/s0079-6123(07)67012-5},
  pmid    = {18037014},
  url     = {https://doi.org/10.1016/s0079-6123(07)67012-5}
}

@article{assaf2008-18157658,
  author  = {Assaf, Y. and Pasternak, O.},
  title   = {{Diffusion tensor imaging (DTI)-based white matter mapping in brain research: a review}},
  journal = {Journal of molecular neuroscience : MN},
  year    = {2008},
  doi     = {10.1007/s12031-007-0029-0},
  pmid    = {18157658},
  url     = {https://doi.org/10.1007/s12031-007-0029-0}
}

@article{head2009-18006193,
  author  = {Head, E. and Corrada, M. M. and Kahle-Wrobleski, K. and Kim, R. C. and Sarsoza, F. and Goodus, M. and Kawas, C. H.},
  title   = {{Synaptic proteins, neuropathology and cognitive status in the oldest-old}},
  journal = {Neurobiology of aging},
  year    = {2009},
  doi     = {10.1016/j.neurobiolaging.2007.10.001},
  pmid    = {18006193},
  url     = {https://doi.org/10.1016/j.neurobiolaging.2007.10.001}
}

@article{chaudhuri2008-18003888,
  author  = {Chaudhuri, A. and Yang, B. and Gendelman, H. E. and Persidsky, Y. and Kanmogne, G. D.},
  title   = {{STAT1 signaling modulates HIV-1-induced inflammatory responses and leukocyte transmigration across the blood-brain barrier}},
  journal = {Blood},
  year    = {2008},
  doi     = {10.1182/blood-2007-05-091207},
  pmid    = {18003888},
  url     = {https://doi.org/10.1182/blood-2007-05-091207}
}

@article{milnerwood2007-17947312,
  author  = {Milnerwood, A. J. and Raymond, L. A.},
  title   = {{Corticostriatal synaptic function in mouse models of Huntington's disease: early effects of huntingtin repeat length and protein load}},
  journal = {The Journal of physiology},
  year    = {2007},
  doi     = {10.1113/jphysiol.2007.142448},
  pmid    = {17947312},
  url     = {https://doi.org/10.1113/jphysiol.2007.142448}
}

@article{moore2008-17913979,
  author  = {Moore, C. I. and Cao, R.},
  title   = {{The hemo-neural hypothesis: on the role of blood flow in information processing}},
  journal = {Journal of neurophysiology},
  year    = {2008},
  doi     = {10.1152/jn.01366.2006},
  pmid    = {17913979},
  url     = {https://doi.org/10.1152/jn.01366.2006}
}

@article{chen2007-18023959,
  author  = {Chen, J. F. and Sonsalla, P. K. and Pedata, F. and Melani, A. and Domenici, M. R. and Popoli, P. and Geiger, J. and Lopes, L. V. and others},
  title   = {{Adenosine A2A receptors and brain injury: broad spectrum of neuroprotection, multifaceted actions and "fine tuning" modulation}},
  journal = {Progress in neurobiology},
  year    = {2007},
  doi     = {10.1016/j.pneurobio.2007.09.002},
  pmid    = {18023959},
  url     = {https://doi.org/10.1016/j.pneurobio.2007.09.002}
}

@article{frey2007-17762510,
  author  = {Frey, B. N. and Andreazza, A. C. and Nery, F. G. and Martins, M. R. and Quevedo, J. and Soares, J. C. and Kapczinski, F.},
  title   = {{The role of hippocampus in the pathophysiology of bipolar disorder}},
  journal = {Behavioural pharmacology},
  year    = {2007},
  doi     = {10.1097/fbp.0b013e3282df3cde},
  pmid    = {17762510},
  url     = {https://doi.org/10.1097/fbp.0b013e3282df3cde}
}

@article{czeh2007-17401728,
  author  = {Czéh, B. and Lucassen, P. J.},
  title   = {{What causes the hippocampal volume decrease in depression? Are neurogenesis, glial changes and apoptosis implicated?}},
  journal = {European archives of psychiatry and clinical neuroscience},
  year    = {2007},
  doi     = {10.1007/s00406-007-0728-0},
  pmid    = {17401728},
  url     = {https://doi.org/10.1007/s00406-007-0728-0}
}

@article{macmaster2008-17640621,
  author  = {MacMaster, F. P. and Mirza, Y. and Szeszko, P. R. and Kmiecik, L. E. and Easter, P. C. and Taormina, S. P. and Lynch, M. and Rose, M. and others},
  title   = {{Amygdala and hippocampal volumes in familial early onset major depressive disorder}},
  journal = {Biological psychiatry},
  year    = {2008},
  doi     = {10.1016/j.biopsych.2007.05.005},
  pmid    = {17640621},
  url     = {https://doi.org/10.1016/j.biopsych.2007.05.005}
}

@article{yucel2008-17406649,
  author  = {Yucel, K. and Taylor, V. H. and McKinnon, M. C. and Macdonald, K. and Alda, M. and Young, L. T. and MacQueen, G. M.},
  title   = {{Bilateral hippocampal volume increase in patients with bipolar disorder and short-term lithium treatment}},
  journal = {Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology},
  year    = {2008},
  doi     = {10.1038/sj.npp.1301405},
  pmid    = {17406649},
  url     = {https://doi.org/10.1038/sj.npp.1301405}
}

@article{centonze2007-17350694,
  author  = {Centonze, D. and Finazzi-Agrò, A. and Bernardi, G. and Maccarrone, M.},
  title   = {{The endocannabinoid system in targeting inflammatory neurodegenerative diseases}},
  journal = {Trends in pharmacological sciences},
  year    = {2007},
  doi     = {10.1016/j.tips.2007.02.004},
  pmid    = {17350694},
  url     = {https://doi.org/10.1016/j.tips.2007.02.004}
}

@article{garzon2007-17344400,
  author  = {Garzon, D. J. and Fahnestock, M.},
  title   = {{Oligomeric amyloid decreases basal levels of brain-derived neurotrophic factor (BDNF) mRNA via specific downregulation of BDNF transcripts IV and V in differentiated human neuroblastoma cells}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2007},
  doi     = {10.1523/jneurosci.5053-06.2007},
  pmid    = {17344400},
  url     = {https://doi.org/10.1523/jneurosci.5053-06.2007}
}

@article{blard2007-17309878,
  author  = {Blard, O. and Feuillette, S. and Bou, J. and Chaumette, B. and Frébourg, T. and Campion, D. and Lecourtois, M.},
  title   = {{Cytoskeleton proteins are modulators of mutant tau-induced neurodegeneration in Drosophila}},
  journal = {Human molecular genetics},
  year    = {2007},
  doi     = {10.1093/hmg/ddm011},
  pmid    = {17309878},
  url     = {https://doi.org/10.1093/hmg/ddm011}
}

@article{kramer2007-17287515,
  author  = {Kramer, M. L. and Schulz-Schaeffer, W. J.},
  title   = {{Presynaptic alpha-synuclein aggregates, not Lewy bodies, cause neurodegeneration in dementia with Lewy bodies}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2007},
  doi     = {10.1523/jneurosci.4564-06.2007},
  pmid    = {17287515},
  url     = {https://doi.org/10.1523/jneurosci.4564-06.2007}
}

@article{wu2006-17167099,
  author  = {Wu, Y. and Wu, Z. and Butko, P. and Christen, Y. and Lambert, M. P. and Klein, W. L. and Link, C. D. and Luo, Y.},
  title   = {{Amyloid-beta-induced pathological behaviors are suppressed by Ginkgo biloba extract EGb 761 and ginkgolides in transgenic Caenorhabditis elegans}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2006},
  doi     = {10.1523/jneurosci.3448-06.2006},
  pmid    = {17167099},
  url     = {https://doi.org/10.1523/jneurosci.3448-06.2006}
}

@article{xie2006-17234824,
  author  = {Xie, Z. and Dong, Y. and Maeda, U. and Moir, R. and Inouye, S. K. and Culley, D. J. and Crosby, G. and Tanzi, R. E.},
  title   = {{Isoflurane-induced apoptosis: a potential pathogenic link between delirium and dementia}},
  journal = {The journals of gerontology. Series A, Biological sciences and medical sciences},
  year    = {2006},
  doi     = {10.1093/gerona/61.12.1300},
  pmid    = {17234824},
  url     = {https://doi.org/10.1093/gerona/61.12.1300}
}

@article{serretti2006-17168841,
  author  = {Serretti, A. and Calati, R. and Mandelli, L. and De Ronchi, D.},
  title   = {{Serotonin transporter gene variants and behavior: a comprehensive review}},
  journal = {Current drug targets},
  year    = {2006},
  doi     = {10.2174/138945006779025419},
  pmid    = {17168841},
  url     = {https://doi.org/10.2174/138945006779025419}
}

@article{engel2006-17059563,
  author  = {Engel, T. and Goñi-Oliver, P. and Lucas, J. J. and Avila, J. and Hernández, F.},
  title   = {{Chronic lithium administration to FTDP-17 tau and GSK-3beta overexpressing mice prevents tau hyperphosphorylation and neurofibrillary tangle formation, but pre-formed neurofibrillary tangles do not revert}},
  journal = {Journal of neurochemistry},
  year    = {2006},
  doi     = {10.1111/j.1471-4159.2006.04139.x},
  pmid    = {17059563},
  url     = {https://doi.org/10.1111/j.1471-4159.2006.04139.x}
}

@article{oddo2006-17056594,
  author  = {Oddo, S. and Vasilevko, V. and Caccamo, A. and Kitazawa, M. and Cribbs, D. H. and LaFerla, F. M.},
  title   = {{Reduction of soluble Abeta and tau, but not soluble Abeta alone, ameliorates cognitive decline in transgenic mice with plaques and tangles}},
  journal = {The Journal of biological chemistry},
  year    = {2006},
  doi     = {10.1074/jbc.m608485200},
  pmid    = {17056594},
  url     = {https://doi.org/10.1074/jbc.m608485200}
}

@article{wen2007-17113760,
  author  = {Wen, Y. and Yang, S. H. and Liu, R. and Perez, E. J. and Brun-Zinkernagel, A. M. and Koulen, P. and Simpkins, J. W.},
  title   = {{Cdk5 is involved in NFT-like tauopathy induced by transient cerebral ischemia in female rats}},
  journal = {Biochimica et biophysica acta},
  year    = {2007},
  doi     = {10.1016/j.bbadis.2006.10.011},
  pmid    = {17113760},
  url     = {https://doi.org/10.1016/j.bbadis.2006.10.011}
}

@article{sairanen2007-17049169,
  author  = {Sairanen, M. and O'Leary, O. F. and Knuuttila, J. E. and Castrén, E.},
  title   = {{Chronic antidepressant treatment selectively increases expression of plasticity-related proteins in the hippocampus and medial prefrontal cortex of the rat}},
  journal = {Neuroscience},
  year    = {2007},
  doi     = {10.1016/j.neuroscience.2006.08.069},
  pmid    = {17049169},
  url     = {https://doi.org/10.1016/j.neuroscience.2006.08.069}
}

@article{miklossy2006-17021400,
  author  = {Miklossy, J. and Arai, T. and Guo, J. P. and Klegeris, A. and Yu, S. and McGeer, E. G. and McGeer, P. L.},
  title   = {{LRRK2 expression in normal and pathologic human brain and in human cell lines}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2006},
  doi     = {10.1097/01.jnen.0000235121.98052.54},
  pmid    = {17021400},
  url     = {https://doi.org/10.1097/01.jnen.0000235121.98052.54}
}

@article{nardone2006-16931146,
  author  = {Nardone, R. and Marth, R. and Ausserer, H. and Bratti, A. and Tezzon, F.},
  title   = {{Reduced short latency afferent inhibition in patients with Down syndrome and Alzheimer-type dementia}},
  journal = {Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology},
  year    = {2006},
  doi     = {10.1016/j.clinph.2006.07.134},
  pmid    = {16931146},
  url     = {https://doi.org/10.1016/j.clinph.2006.07.134}
}

@article{kelly2006-16864575,
  author  = {Kelly, B. L. and Ferreira, A.},
  title   = {{beta-Amyloid-induced dynamin 1 degradation is mediated by N-methyl-D-aspartate receptors in hippocampal neurons}},
  journal = {The Journal of biological chemistry},
  year    = {2006},
  doi     = {10.1074/jbc.m605081200},
  pmid    = {16864575},
  url     = {https://doi.org/10.1074/jbc.m605081200}
}

@article{lorenzi2006-16828061,
  author  = {Lorenzi, H. A. and Reeves, R. H.},
  title   = {{Hippocampal hypocellularity in the Ts65Dn mouse originates early in development}},
  journal = {Brain research},
  year    = {2006},
  doi     = {10.1016/j.brainres.2006.05.022},
  pmid    = {16828061},
  url     = {https://doi.org/10.1016/j.brainres.2006.05.022}
}

@article{counts2006-16783169,
  author  = {Counts, S. E. and Nadeem, M. and Lad, S. P. and Wuu, J. and Mufson, E. J.},
  title   = {{Differential expression of synaptic proteins in the frontal and temporal cortex of elderly subjects with mild cognitive impairment}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2006},
  doi     = {10.1097/00005072-200606000-00007},
  pmid    = {16783169},
  url     = {https://doi.org/10.1097/00005072-200606000-00007}
}

@article{chong2006-16714296,
  author  = {Chong, Y. H. and Shin, Y. J. and Lee, E. O. and Kayed, R. and Glabe, C. G. and Tenner, A. J.},
  title   = {{ERK1/2 activation mediates Abeta oligomer-induced neurotoxicity via caspase-3 activation and tau cleavage in rat organotypic hippocampal slice cultures}},
  journal = {The Journal of biological chemistry},
  year    = {2006},
  doi     = {10.1074/jbc.m601016200},
  pmid    = {16714296},
  url     = {https://doi.org/10.1074/jbc.m601016200}
}

@article{spires2006-16651626,
  author  = {Spires, T. L. and Orne, J. D. and SantaCruz, K. and Pitstick, R. and Carlson, G. A. and Ashe, K. H. and Hyman, B. T.},
  title   = {{Region-specific dissociation of neuronal loss and neurofibrillary pathology in a mouse model of tauopathy}},
  journal = {The American journal of pathology},
  year    = {2006},
  doi     = {10.2353/ajpath.2006.050840},
  pmid    = {16651626},
  url     = {https://doi.org/10.2353/ajpath.2006.050840}
}

@article{josephs2006-16691120,
  author  = {Josephs, K. A. and Katsuse, O. and Beccano-Kelly, D. A. and Lin, W. L. and Uitti, R. J. and Fujino, Y. and Boeve, B. F. and Hutton, M. L. and others},
  title   = {{Atypical progressive supranuclear palsy with corticospinal tract degeneration}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2006},
  doi     = {10.1097/01.jnen.0000218446.38158.61},
  pmid    = {16691120},
  url     = {https://doi.org/10.1097/01.jnen.0000218446.38158.61}
}

@article{boekhoorn2006-16571759,
  author  = {Boekhoorn, K. and Terwel, D. and Biemans, B. and Borghgraef, P. and Wiegert, O. and Ramakers, G. J. and de Vos, K. and Krugers, H. and others},
  title   = {{Improved long-term potentiation and memory in young tau-P301L transgenic mice before onset of hyperphosphorylation and tauopathy}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2006},
  doi     = {10.1523/jneurosci.5425-05.2006},
  pmid    = {16571759},
  url     = {https://doi.org/10.1523/jneurosci.5425-05.2006}
}

@article{deramecourt2006-16651889,
  author  = {Deramecourt, V. and Bombois, S. and Maurage, C. A. and Ghestem, A. and Drobecq, H. and Vanmechelen, E. and Lebert, F. and Pasquier, F. and others},
  title   = {{Biochemical staging of synucleinopathy and amyloid deposition in dementia with Lewy bodies}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2006},
  doi     = {10.1097/01.jnen.0000205145.54457.ea},
  pmid    = {16651889},
  url     = {https://doi.org/10.1097/01.jnen.0000205145.54457.ea}
}

@article{jayatissa2006-16482085,
  author  = {Jayatissa, M. N. and Bisgaard, C. and Tingström, A. and Papp, M. and Wiborg, O.},
  title   = {{Hippocampal cytogenesis correlates to escitalopram-mediated recovery in a chronic mild stress rat model of depression}},
  journal = {Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology},
  year    = {2006},
  doi     = {10.1038/sj.npp.1301041},
  pmid    = {16482085},
  url     = {https://doi.org/10.1038/sj.npp.1301041}
}

@article{bueller2006-16442082,
  author  = {Bueller, J. A. and Aftab, M. and Sen, S. and Gomez-Hassan, D. and Burmeister, M. and Zubieta, J. K.},
  title   = {{BDNF Val66Met allele is associated with reduced hippocampal volume in healthy subjects}},
  journal = {Biological psychiatry},
  year    = {2006},
  doi     = {10.1016/j.biopsych.2005.09.022},
  pmid    = {16442082},
  url     = {https://doi.org/10.1016/j.biopsych.2005.09.022}
}

@article{dabir2006-16407562,
  author  = {Dabir, D. V. and Robinson, M. B. and Swanson, E. and Zhang, B. and Trojanowski, J. Q. and Lee, V. M. and Forman, M. S.},
  title   = {{Impaired glutamate transport in a mouse model of tau pathology in astrocytes}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2006},
  doi     = {10.1523/jneurosci.3861-05.2006},
  pmid    = {16407562},
  url     = {https://doi.org/10.1523/jneurosci.3861-05.2006}
}

@article{berger2006-16368705,
  author  = {Berger, Z. and Ravikumar, B. and Menzies, F. M. and Oroz, L. G. and Underwood, B. R. and Pangalos, M. N. and Schmitt, I. and Wullner, U. and others},
  title   = {{Rapamycin alleviates toxicity of different aggregate-prone proteins}},
  journal = {Human molecular genetics},
  year    = {2006},
  doi     = {10.1093/hmg/ddi458},
  pmid    = {16368705},
  url     = {https://doi.org/10.1093/hmg/ddi458}
}

@article{czeh2006-16395301,
  author  = {Czéh, B. and Simon, M. and Schmelting, B. and Hiemke, C. and Fuchs, E.},
  title   = {{Astroglial plasticity in the hippocampus is affected by chronic psychosocial stress and concomitant fluoxetine treatment}},
  journal = {Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology},
  year    = {2006},
  doi     = {10.1038/sj.npp.1300982},
  pmid    = {16395301},
  url     = {https://doi.org/10.1038/sj.npp.1300982}
}

@article{miyasaka2005-16242642,
  author  = {Miyasaka, T. and Ding, Z. and Gengyo-Ando, K. and Oue, M. and Yamaguchi, H. and Mitani, S. and Ihara, Y.},
  title   = {{Progressive neurodegeneration in C. elegans model of tauopathy}},
  journal = {Neurobiology of disease},
  year    = {2005},
  doi     = {10.1016/j.nbd.2005.03.017},
  pmid    = {16242642},
  url     = {https://doi.org/10.1016/j.nbd.2005.03.017}
}

@article{khlistunova2006-16246844,
  author  = {Khlistunova, I. and Biernat, J. and Wang, Y. and Pickhardt, M. and von Bergen, M. and Gazova, Z. and Mandelkow, E. and Mandelkow, E. M.},
  title   = {{Inducible expression of Tau repeat domain in cell models of tauopathy: aggregation is toxic to cells but can be reversed by inhibitor drugs}},
  journal = {The Journal of biological chemistry},
  year    = {2006},
  doi     = {10.1074/jbc.m507753200},
  pmid    = {16246844},
  url     = {https://doi.org/10.1074/jbc.m507753200}
}

@article{murakami2005-16024125,
  author  = {Murakami, S. and Imbe, H. and Morikawa, Y. and Kubo, C. and Senba, E.},
  title   = {{Chronic stress, as well as acute stress, reduces BDNF mRNA expression in the rat hippocampus but less robustly}},
  journal = {Neuroscience research},
  year    = {2005},
  doi     = {10.1016/j.neures.2005.06.008},
  pmid    = {16024125},
  url     = {https://doi.org/10.1016/j.neures.2005.06.008}
}

@article{armulik2005-16166562,
  author  = {Armulik, A. and Abramsson, A. and Betsholtz, C.},
  title   = {{Endothelial/pericyte interactions}},
  journal = {Circulation research},
  year    = {2005},
  doi     = {10.1161/01.res.0000182903.16652.d7},
  pmid    = {16166562},
  url     = {https://doi.org/10.1161/01.res.0000182903.16652.d7}
}

@article{bhaskar2005-16115884,
  author  = {Bhaskar, K. and Yen, S. H. and Lee, G.},
  title   = {{Disease-related modifications in tau affect the interaction between Fyn and Tau}},
  journal = {The Journal of biological chemistry},
  year    = {2005},
  doi     = {10.1074/jbc.m505895200},
  pmid    = {16115884},
  url     = {https://doi.org/10.1074/jbc.m505895200}
}

@article{kelly2005-16002400,
  author  = {Kelly, B. L. and Vassar, R. and Ferreira, A.},
  title   = {{Beta-amyloid-induced dynamin 1 depletion in hippocampal neurons. A potential mechanism for early cognitive decline in Alzheimer disease}},
  journal = {The Journal of biological chemistry},
  year    = {2005},
  doi     = {10.1074/jbc.m503259200},
  pmid    = {16002400},
  url     = {https://doi.org/10.1074/jbc.m503259200}
}

@article{lodygensky2005-15995023,
  author  = {Lodygensky, G. A. and Rademaker, K. and Zimine, S. and Gex-Fabry, M. and Lieftink, A. F. and Lazeyras, F. and Groenendaal, F. and de Vries, L. S. and others},
  title   = {{Structural and functional brain development after hydrocortisone treatment for neonatal chronic lung disease}},
  journal = {Pediatrics},
  year    = {2005},
  doi     = {10.1542/peds.2004-1275},
  pmid    = {15995023},
  url     = {https://doi.org/10.1542/peds.2004-1275}
}

@article{forman2005-15814784,
  author  = {Forman, M. S. and Lal, D. and Zhang, B. and Dabir, D. V. and Swanson, E. and Lee, V. M. and Trojanowski, J. Q.},
  title   = {{Transgenic mouse model of tau pathology in astrocytes leading to nervous system degeneration}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2005},
  doi     = {10.1523/jneurosci.0081-05.2005},
  pmid    = {15814784},
  url     = {https://doi.org/10.1523/jneurosci.0081-05.2005}
}

@article{pamplona2005-15799962,
  author  = {Pamplona, R. and Dalfó, E. and Ayala, V. and Bellmunt, M. J. and Prat, J. and Ferrer, I. and Portero-Otín, M.},
  title   = {{Proteins in human brain cortex are modified by oxidation, glycoxidation, and lipoxidation. Effects of Alzheimer disease and identification of lipoxidation targets}},
  journal = {The Journal of biological chemistry},
  year    = {2005},
  doi     = {10.1074/jbc.m502255200},
  pmid    = {15799962},
  url     = {https://doi.org/10.1074/jbc.m502255200}
}

@article{malberg2005-15638755,
  author  = {Malberg, J. E. and Schechter, L. E.},
  title   = {{Increasing hippocampal neurogenesis: a novel mechanism for antidepressant drugs}},
  journal = {Current pharmaceutical design},
  year    = {2005},
  doi     = {10.2174/1381612053382223},
  pmid    = {15638755},
  url     = {https://doi.org/10.2174/1381612053382223}
}

@article{chiesa2005-15618403,
  author  = {Chiesa, R. and Piccardo, P. and Dossena, S. and Nowoslawski, L. and Roth, K. A. and Ghetti, B. and Harris, D. A.},
  title   = {{Bax deletion prevents neuronal loss but not neurological symptoms in a transgenic model of inherited prion disease}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2005},
  doi     = {10.1073/pnas.0406173102},
  pmid    = {15618403},
  url     = {https://doi.org/10.1073/pnas.0406173102}
}

@article{vanmarle2004-15518810,
  author  = {van Marle, G. and Henry, S. and Todoruk, T. and Sullivan, A. and Silva, C. and Rourke, S. B. and Holden, J. and McArthur, J. C. and others},
  title   = {{Human immunodeficiency virus type 1 Nef protein mediates neural cell death: a neurotoxic role for IP-10}},
  journal = {Virology},
  year    = {2004},
  doi     = {10.1016/j.virol.2004.08.024},
  pmid    = {15518810},
  url     = {https://doi.org/10.1016/j.virol.2004.08.024}
}

@article{wen2004-15353210,
  author  = {Wen, Y. and Yang, S. and Liu, R. and Simpkins, J. W.},
  title   = {{Transient cerebral ischemia induces site-specific hyperphosphorylation of tau protein}},
  journal = {Brain research},
  year    = {2004},
  doi     = {10.1016/j.brainres.2004.05.106},
  pmid    = {15353210},
  url     = {https://doi.org/10.1016/j.brainres.2004.05.106}
}

@article{hatakeyama2004-15447663,
  author  = {Hatakeyama, S. and Matsumoto, M. and Kamura, T. and Murayama, M. and Chui, D. H. and Planel, E. and Takahashi, R. and Nakayama, K. I. and others},
  title   = {{U-box protein carboxyl terminus of Hsc70-interacting protein (CHIP) mediates poly-ubiquitylation preferentially on four-repeat Tau and is involved in neurodegeneration of tauopathy}},
  journal = {Journal of neurochemistry},
  year    = {2004},
  doi     = {10.1111/j.1471-4159.2004.02713.x},
  pmid    = {15447663},
  url     = {https://doi.org/10.1111/j.1471-4159.2004.02713.x}
}

@article{chen2004-15270197,
  author  = {Chen, F. and David, D. and Ferrari, A. and Götz, J.},
  title   = {{Posttranslational modifications of tau--role in human tauopathies and modeling in transgenic animals}},
  journal = {Current drug targets},
  year    = {2004},
  doi     = {10.2174/1389450043345236},
  pmid    = {15270197},
  url     = {https://doi.org/10.2174/1389450043345236}
}

@article{lange2004-15554576,
  author  = {Lange, C. and Irle, E.},
  title   = {{Enlarged amygdala volume and reduced hippocampal volume in young women with major depression}},
  journal = {Psychological medicine},
  year    = {2004},
  doi     = {10.1017/s0033291703001806},
  pmid    = {15554576},
  url     = {https://doi.org/10.1017/s0033291703001806}
}

@article{shigeri2004-15210307,
  author  = {Shigeri, Y. and Seal, R. P. and Shimamoto, K.},
  title   = {{Molecular pharmacology of glutamate transporters, EAATs and VGLUTs}},
  journal = {Brain research. Brain research reviews},
  year    = {2004},
  doi     = {10.1016/j.brainresrev.2004.04.004},
  pmid    = {15210307},
  url     = {https://doi.org/10.1016/j.brainresrev.2004.04.004}
}

@article{zhang2004-15140937,
  author  = {Zhang, B. and Higuchi, M. and Yoshiyama, Y. and Ishihara, T. and Forman, M. S. and Martinez, D. and Joyce, S. and Trojanowski, J. Q. and others},
  title   = {{Retarded axonal transport of R406W mutant tau in transgenic mice with a neurodegenerative tauopathy}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2004},
  doi     = {10.1523/jneurosci.0797-04.2004},
  pmid    = {15140937},
  url     = {https://doi.org/10.1523/jneurosci.0797-04.2004}
}

@article{malberg2004-15173896,
  author  = {Malberg, J. E.},
  title   = {{Implications of adult hippocampal neurogenesis in antidepressant action}},
  journal = {Journal of psychiatry \& neuroscience : JPN},
  year    = {2004},
  doi     = {10.1139/jpn.0422},
  pmid    = {15173896},
  url     = {https://doi.org/10.1139/jpn.0422}
}

@article{finsterer2004-15009163,
  author  = {Finsterer, J.},
  title   = {{Mitochondriopathies}},
  journal = {European journal of neurology},
  year    = {2004},
  doi     = {10.1046/j.1351-5101.2003.00728.x},
  pmid    = {15009163},
  url     = {https://doi.org/10.1046/j.1351-5101.2003.00728.x}
}

@article{wen2004-14982935,
  author  = {Wen, Y. and Yang, S. and Liu, R. and Brun-Zinkernagel, A. M. and Koulen, P. and Simpkins, J. W.},
  title   = {{Transient cerebral ischemia induces aberrant neuronal cell cycle re-entry and Alzheimer's disease-like tauopathy in female rats}},
  journal = {The Journal of biological chemistry},
  year    = {2004},
  doi     = {10.1074/jbc.m311768200},
  pmid    = {14982935},
  url     = {https://doi.org/10.1074/jbc.m311768200}
}

@article{isgor2004-15301440,
  author  = {Isgor, C. and Kabbaj, M. and Akil, H. and Watson, S. J.},
  title   = {{Delayed effects of chronic variable stress during peripubertal-juvenile period on hippocampal morphology and on cognitive and stress axis functions in rats}},
  journal = {Hippocampus},
  year    = {2004},
  doi     = {10.1002/hipo.10207},
  pmid    = {15301440},
  url     = {https://doi.org/10.1002/hipo.10207}
}

@article{heine2004-14750971,
  author  = {Heine, V. M. and Maslam, S. and Zareno, J. and Joëls, M. and Lucassen, P. J.},
  title   = {{Suppressed proliferation and apoptotic changes in the rat dentate gyrus after acute and chronic stress are reversible}},
  journal = {The European journal of neuroscience},
  year    = {2004},
  doi     = {10.1046/j.1460-9568.2003.03100.x},
  pmid    = {14750971},
  url     = {https://doi.org/10.1046/j.1460-9568.2003.03100.x}
}

@article{gale2004-14751008,
  author  = {Gale, S. D. and Hopkins, R. O.},
  title   = {{Effects of hypoxia on the brain: neuroimaging and neuropsychological findings following carbon monoxide poisoning and obstructive sleep apnea}},
  journal = {Journal of the International Neuropsychological Society : JINS},
  year    = {2004},
  doi     = {10.1017/s1355617704101082},
  pmid    = {14751008},
  url     = {https://doi.org/10.1017/s1355617704101082}
}

@article{lipton2004-15717010,
  author  = {Lipton, S. A.},
  title   = {{Failures and successes of NMDA receptor antagonists: molecular basis for the use of open-channel blockers like memantine in the treatment of acute and chronic neurologic insults}},
  journal = {NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics},
  year    = {2004},
  doi     = {10.1602/neurorx.1.1.101},
  pmid    = {15717010},
  url     = {https://doi.org/10.1602/neurorx.1.1.101}
}

@article{shulman2003-14668378,
  author  = {Shulman, J. M. and Feany, M. B.},
  title   = {{Genetic modifiers of tauopathy in Drosophila}},
  journal = {Genetics},
  year    = {2003},
  doi     = {10.1093/genetics/165.3.1233},
  pmid    = {14668378},
  url     = {https://doi.org/10.1093/genetics/165.3.1233}
}

@article{coe2003-14625144,
  author  = {Coe, C. L. and Kramer, M. and Czéh, B. and Gould, E. and Reeves, A. J. and Kirschbaum, C. and Fuchs, E.},
  title   = {{Prenatal stress diminishes neurogenesis in the dentate gyrus of juvenile rhesus monkeys}},
  journal = {Biological psychiatry},
  year    = {2003},
  doi     = {10.1016/s0006-3223(03)00698-x},
  pmid    = {14625144},
  url     = {https://doi.org/10.1016/s0006-3223(03)00698-x}
}

@article{gorry2003-15049431,
  author  = {Gorry, P. R. and Ong, C. and Thorpe, J. and Bannwarth, S. and Thompson, K. A. and Gatignol, A. and Vesselingh, S. L. and Purcell, D. F.},
  title   = {{Astrocyte infection by HIV-1: mechanisms of restricted virus replication, and role in the pathogenesis of HIV-1-associated dementia}},
  journal = {Current HIV research},
  year    = {2003},
  doi     = {10.2174/1570162033485122},
  pmid    = {15049431},
  url     = {https://doi.org/10.2174/1570162033485122}
}

@article{schlueter2003-14580673,
  author  = {Schlueter, C. and Hauke, S. and Flohr, A. M. and Rogalla, P. and Bullerdiek, J.},
  title   = {{Tissue-specific expression patterns of the RAGE receptor and its soluble forms--a result of regulated alternative splicing?}},
  journal = {Biochimica et biophysica acta},
  year    = {2003},
  doi     = {10.1016/j.bbaexp.2003.08.008},
  pmid    = {14580673},
  url     = {https://doi.org/10.1016/j.bbaexp.2003.08.008}
}

@article{brucekeller2003-12968004,
  author  = {Bruce-Keller, A. J. and Chauhan, A. and Dimayuga, F. O. and Gee, J. and Keller, J. N. and Nath, A.},
  title   = {{Synaptic transport of human immunodeficiency virus-Tat protein causes neurotoxicity and gliosis in rat brain}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2003},
  doi     = {10.1523/jneurosci.23-23-08417.2003},
  pmid    = {12968004},
  url     = {https://doi.org/10.1523/jneurosci.23-23-08417.2003}
}

@article{kraemer2003-12872001,
  author  = {Kraemer, B. C. and Zhang, B. and Leverenz, J. B. and Thomas, J. H. and Trojanowski, J. Q. and Schellenberg, G. D.},
  title   = {{Neurodegeneration and defective neurotransmission in a Caenorhabditis elegans model of tauopathy}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2003},
  doi     = {10.1073/pnas.1533448100},
  pmid    = {12872001},
  url     = {https://doi.org/10.1073/pnas.1533448100}
}

@article{yamasue2003-12853571,
  author  = {Yamasue, H. and Kasai, K. and Iwanami, A. and Ohtani, T. and Yamada, H. and Abe, O. and Kuroki, N. and Fukuda, R. and others},
  title   = {{Voxel-based analysis of MRI reveals anterior cingulate gray-matter volume reduction in posttraumatic stress disorder due to terrorism}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2003},
  doi     = {10.1073/pnas.1530467100},
  pmid    = {12853571},
  url     = {https://doi.org/10.1073/pnas.1530467100}
}

@article{camicioli2003-12815657,
  author  = {Camicioli, R. and Moore, M. M. and Kinney, A. and Corbridge, E. and Glassberg, K. and Kaye, J. A.},
  title   = {{Parkinson's disease is associated with hippocampal atrophy}},
  journal = {Movement disorders : official journal of the Movement Disorder Society},
  year    = {2003},
  doi     = {10.1002/mds.10444},
  pmid    = {12815657},
  url     = {https://doi.org/10.1002/mds.10444}
}

@article{mehta2003-12757888,
  author  = {Mehta, P. D. and Mehta, S. P. and Fedor, B. and Patrick, B. A. and Emmerling, M. and Dalton, A. J.},
  title   = {{Plasma amyloid beta protein 1-42 levels are increased in old Down Syndrome but not in young Down Syndrome}},
  journal = {Neuroscience letters},
  year    = {2003},
  doi     = {10.1016/s0304-3940(03)00275-1},
  pmid    = {12757888},
  url     = {https://doi.org/10.1016/s0304-3940(03)00275-1}
}

@article{bremner2003-12727697,
  author  = {Bremner, J. D. and Vythilingam, M. and Vermetten, E. and Southwick, S. M. and McGlashan, T. and Nazeer, A. and Khan, S. and Vaccarino, L. V. and others},
  title   = {{MRI and PET study of deficits in hippocampal structure and function in women with childhood sexual abuse and posttraumatic stress disorder}},
  journal = {The American journal of psychiatry},
  year    = {2003},
  doi     = {10.1176/appi.ajp.160.5.924},
  pmid    = {12727697},
  url     = {https://doi.org/10.1176/appi.ajp.160.5.924}
}

@article{hirayama2003-12689696,
  author  = {Hirayama, A. and Horikoshi, Y. and Maeda, M. and Ito, M. and Takashima, S.},
  title   = {{Characteristic developmental expression of amyloid beta40, 42 and 43 in patients with Down syndrome}},
  journal = {Brain \& development},
  year    = {2003},
  doi     = {10.1016/s0387-7604(02)00209-7},
  pmid    = {12689696},
  url     = {https://doi.org/10.1016/s0387-7604(02)00209-7}
}

@article{guillemin2003-12555204,
  author  = {Guillemin, G. J. and Croitoru-Lamoury, J. and Dormont, D. and Armati, P. J. and Brew, B. J.},
  title   = {{Quinolinic acid upregulates chemokine production and chemokine receptor expression in astrocytes}},
  journal = {Glia},
  year    = {2003},
  doi     = {10.1002/glia.10175},
  pmid    = {12555204},
  url     = {https://doi.org/10.1002/glia.10175}
}

@article{wardlaw2003-12624314,
  author  = {Wardlaw, J. M. and Sandercock, P. A. and Dennis, M. S. and Starr, J.},
  title   = {{Is breakdown of the blood-brain barrier responsible for lacunar stroke, leukoaraiosis, and dementia?}},
  journal = {Stroke},
  year    = {2003},
  doi     = {10.1161/01.str.0000058480.77236.b3},
  pmid    = {12624314},
  url     = {https://doi.org/10.1161/01.str.0000058480.77236.b3}
}

@article{su2003-12578975,
  author  = {Su, Z. Z. and Leszczyniecka, M. and Kang, D. C. and Sarkar, D. and Chao, W. and Volsky, D. J. and Fisher, P. B.},
  title   = {{Insights into glutamate transport regulation in human astrocytes: cloning of the promoter for excitatory amino acid transporter 2 (EAAT2)}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2003},
  doi     = {10.1073/pnas.0136555100},
  pmid    = {12578975},
  url     = {https://doi.org/10.1073/pnas.0136555100}
}

@article{chauhan2003-12551932,
  author  = {Chauhan, A. and Turchan, J. and Pocernich, C. and Bruce-Keller, A. and Roth, S. and Butterfield, D. A. and Major, E. O. and Nath, A.},
  title   = {{Intracellular human immunodeficiency virus Tat expression in astrocytes promotes astrocyte survival but induces potent neurotoxicity at distant sites via axonal transport}},
  journal = {The Journal of biological chemistry},
  year    = {2003},
  doi     = {10.1074/jbc.m209381200},
  pmid    = {12551932},
  url     = {https://doi.org/10.1074/jbc.m209381200}
}

@article{shim2003-15068244,
  author  = {Shim, K. S. and Bergelson, J. M. and Furuse, M. and Ovod, V. and Krude, T. and Lubec, G.},
  title   = {{Reduction of chromatin assembly factor 1 p60 and C21orf2 protein, encoded on chromosome 21, in Down syndrome brain}},
  journal = {Journal of neural transmission. Supplementum},
  year    = {2003},
  doi     = {10.1007/978-3-7091-6721-2_10},
  pmid    = {15068244},
  url     = {https://doi.org/10.1007/978-3-7091-6721-2_10}
}

@article{macmillan2003-12804127,
  author  = {MacMillan, S. and Szeszko, P. R. and Moore, G. J. and Madden, R. and Lorch, E. and Ivey, J. and Banerjee, S. P. and Rosenberg, D. R.},
  title   = {{Increased amygdala: hippocampal volume ratios associated with severity of anxiety in pediatric major depression}},
  journal = {Journal of child and adolescent psychopharmacology},
  year    = {2003},
  doi     = {10.1089/104454603321666207},
  pmid    = {12804127},
  url     = {https://doi.org/10.1089/104454603321666207}
}

@article{csernansky2002-12450948,
  author  = {Csernansky, J. G. and Wang, L. and Jones, D. and Rastogi-Cruz, D. and Posener, J. A. and Heydebrand, G. and Miller, J. P. and Miller, M. I.},
  title   = {{Hippocampal deformities in schizophrenia characterized by high dimensional brain mapping}},
  journal = {The American journal of psychiatry},
  year    = {2002},
  doi     = {10.1176/appi.ajp.159.12.2000},
  pmid    = {12450948},
  url     = {https://doi.org/10.1176/appi.ajp.159.12.2000}
}

@article{tatebayashi2002-12368474,
  author  = {Tatebayashi, Y. and Miyasaka, T. and Chui, D. H. and Akagi, T. and Mishima, K. and Iwasaki, K. and Fujiwara, M. and Tanemura, K. and others},
  title   = {{Tau filament formation and associative memory deficit in aged mice expressing mutant (R406W) human tau}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2002},
  doi     = {10.1073/pnas.202205599},
  pmid    = {12368474},
  url     = {https://doi.org/10.1073/pnas.202205599}
}

@article{clements2002-12232830,
  author  = {Clements, J. E. and Babas, T. and Mankowski, J. L. and Suryanarayana, K. and Piatak, M. and Tarwater, P. M. and Lifson, J. D. and Zink, M. C.},
  title   = {{The central nervous system as a reservoir for simian immunodeficiency virus (SIV): steady-state levels of SIV DNA in brain from acute through asymptomatic infection}},
  journal = {The Journal of infectious diseases},
  year    = {2002},
  doi     = {10.1086/343768},
  pmid    = {12232830},
  url     = {https://doi.org/10.1086/343768}
}

@article{maier2002-12194501,
  author  = {Maier, C. M. and Chan, P. H.},
  title   = {{Role of superoxide dismutases in oxidative damage and neurodegenerative disorders}},
  journal = {The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry},
  year    = {2002},
  doi     = {10.1177/107385840200800408},
  pmid    = {12194501},
  url     = {https://doi.org/10.1177/107385840200800408}
}

@article{villarreal2002-12114003,
  author  = {Villarreal, G. and Hamilton, D. A. and Petropoulos, H. and Driscoll, I. and Rowland, L. M. and Griego, J. A. and Kodituwakku, P. W. and Hart, B. L. and others},
  title   = {{Reduced hippocampal volume and total white matter volume in posttraumatic stress disorder}},
  journal = {Biological psychiatry},
  year    = {2002},
  doi     = {10.1016/s0006-3223(02)01359-8},
  pmid    = {12114003},
  url     = {https://doi.org/10.1016/s0006-3223(02)01359-8}
}

@article{kalimo2002-12146805,
  author  = {Kalimo, H. and Ruchoux, M. M. and Viitanen, M. and Kalaria, R. N.},
  title   = {{CADASIL: a common form of hereditary arteriopathy causing brain infarcts and dementia}},
  journal = {Brain pathology (Zurich, Switzerland)},
  year    = {2002},
  doi     = {10.1111/j.1750-3639.2002.tb00451.x},
  pmid    = {12146805},
  url     = {https://doi.org/10.1111/j.1750-3639.2002.tb00451.x}
}

@article{fiscus2002-12393944,
  author  = {Fiscus, R. R.},
  title   = {{Involvement of cyclic GMP and protein kinase G in the regulation of apoptosis and survival in neural cells}},
  journal = {Neuro-Signals},
  year    = {2002},
  doi     = {10.1159/000065431},
  pmid    = {12393944},
  url     = {https://doi.org/10.1159/000065431}
}

@article{rampoldi2002-12185448,
  author  = {Rampoldi, L. and Danek, A. and Monaco, A. P.},
  title   = {{Clinical features and molecular bases of neuroacanthocytosis}},
  journal = {Journal of molecular medicine (Berlin, Germany)},
  year    = {2002},
  doi     = {10.1007/s00109-002-0349-z},
  pmid    = {12185448},
  url     = {https://doi.org/10.1007/s00109-002-0349-z}
}

@article{togo2002-12071638,
  author  = {Togo, T. and Sahara, N. and Yen, S. H. and Cookson, N. and Ishizawa, T. and Hutton, M. and de Silva, R. and Lees, A. and others},
  title   = {{Argyrophilic grain disease is a sporadic 4-repeat tauopathy}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2002},
  doi     = {10.1093/jnen/61.6.547},
  pmid    = {12071638},
  url     = {https://doi.org/10.1093/jnen/61.6.547}
}

@article{heckers2002-12111476,
  author  = {Heckers, S. and Konradi, C.},
  title   = {{Hippocampal neurons in schizophrenia}},
  journal = {Journal of neural transmission (Vienna, Austria : 1996)},
  year    = {2002},
  doi     = {10.1007/s007020200073},
  pmid    = {12111476},
  url     = {https://doi.org/10.1007/s007020200073}
}

@article{lee2002-12071509,
  author  = {Lee, A. L. and Ogle, W. O. and Sapolsky, R. M.},
  title   = {{Stress and depression: possible links to neuron death in the hippocampus}},
  journal = {Bipolar disorders},
  year    = {2002},
  doi     = {10.1034/j.1399-5618.2002.01144.x},
  pmid    = {12071509},
  url     = {https://doi.org/10.1034/j.1399-5618.2002.01144.x}
}

@article{steffenach2002-11867718,
  author  = {Steffenach, H. A. and Sloviter, R. S. and Moser, E. I. and Moser, M. B.},
  title   = {{Impaired retention of spatial memory after transection of longitudinally oriented axons of hippocampal CA3 pyramidal cells}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2002},
  doi     = {10.1073/pnas.042700999},
  pmid    = {11867718},
  url     = {https://doi.org/10.1073/pnas.042700999}
}

@article{levinallerhand2002-12474021,
  author  = {Levin-Allerhand, J. A. and Lominska, C. E. and Smith, J. D.},
  title   = {{Increased amyloid- levels in APPSWE transgenic mice treated chronically with a physiological high-fat high-cholesterol diet}},
  journal = {The journal of nutrition, health \& aging},
  year    = {2002},
  pmid    = {12474021}
}

@article{carrion2001-11750890,
  author  = {Carrion, V. G. and Weems, C. F. and Eliez, S. and Patwardhan, A. and Brown, W. and Ray, R. D. and Reiss, A. L.},
  title   = {{Attenuation of frontal asymmetry in pediatric posttraumatic stress disorder}},
  journal = {Biological psychiatry},
  year    = {2001},
  doi     = {10.1016/s0006-3223(01)01218-5},
  pmid    = {11750890},
  url     = {https://doi.org/10.1016/s0006-3223(01)01218-5}
}

@article{sheng2001-11578769,
  author  = {Sheng, J. G. and Jones, R. A. and Zhou, X. Q. and McGinness, J. M. and Van Eldik, L. J. and Mrak, R. E. and Griffin, W. S.},
  title   = {{Interleukin-1 promotion of MAPK-p38 overexpression in experimental animals and in Alzheimer's disease: potential significance for tau protein phosphorylation}},
  journal = {Neurochemistry international},
  year    = {2001},
  doi     = {10.1016/s0197-0186(01)00041-9},
  pmid    = {11578769},
  url     = {https://doi.org/10.1016/s0197-0186(01)00041-9}
}

@article{golarai2001-11606641,
  author  = {Golarai, G. and Greenwood, A. C. and Feeney, D. M. and Connor, J. A.},
  title   = {{Physiological and structural evidence for hippocampal involvement in persistent seizure susceptibility after traumatic brain injury}},
  journal = {The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year    = {2001},
  doi     = {10.1523/jneurosci.21-21-08523.2001},
  pmid    = {11606641},
  url     = {https://doi.org/10.1523/jneurosci.21-21-08523.2001}
}

@article{czeh2001-11675510,
  author  = {Czéh, B. and Michaelis, T. and Watanabe, T. and Frahm, J. and de Biurrun, G. and van Kampen, M. and Bartolomucci, A. and Fuchs, E.},
  title   = {{Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine}},
  journal = {Proceedings of the National Academy of Sciences of the United States of America},
  year    = {2001},
  doi     = {10.1073/pnas.211427898},
  pmid    = {11675510},
  url     = {https://doi.org/10.1073/pnas.211427898}
}

@article{varghese2001-15014598,
  author  = {Varghese, F. P. and Brown, E. S.},
  title   = {{The Hypothalamic-Pituitary-Adrenal Axis in Major Depressive Disorder: A Brief Primer for Primary Care Physicians}},
  journal = {Primary care companion to the Journal of clinical psychiatry},
  year    = {2001},
  doi     = {10.4088/pcc.v03n0401},
  pmid    = {15014598},
  url     = {https://doi.org/10.4088/pcc.v03n0401}
}

@article{castellani2001-11440829,
  author  = {Castellani, R. J. and Harris, P. L. and Sayre, L. M. and Fujii, J. and Taniguchi, N. and Vitek, M. P. and Founds, H. and Atwood, C. S. and others},
  title   = {{Active glycation in neurofibrillary pathology of Alzheimer disease: N(epsilon)-(carboxymethyl) lysine and hexitol-lysine}},
  journal = {Free radical biology \& medicine},
  year    = {2001},
  doi     = {10.1016/s0891-5849(01)00570-6},
  pmid    = {11440829},
  url     = {https://doi.org/10.1016/s0891-5849(01)00570-6}
}

@article{anello2001-11403974,
  author  = {Anello, G. and Guéant, J. and Romano, C. and Barone, C. and Pettinato, R. and Pillot, T. and Rodriguez, R. and Romano, A. and others},
  title   = {{Allele varepsilon4 of apolipoprotein E gene is less frequent in Down syndrome patient of the Sicilian population and has no influence on the grade of mental retardation}},
  journal = {Neuroscience letters},
  year    = {2001},
  doi     = {10.1016/s0304-3940(01)01851-1},
  pmid    = {11403974},
  url     = {https://doi.org/10.1016/s0304-3940(01)01851-1}
}

@article{stone2001-11240212,
  author  = {Stone, T. W.},
  title   = {{Kynurenines in the CNS: from endogenous obscurity to therapeutic importance}},
  journal = {Progress in neurobiology},
  year    = {2001},
  doi     = {10.1016/s0301-0082(00)00032-0},
  pmid    = {11240212},
  url     = {https://doi.org/10.1016/s0301-0082(00)00032-0}
}

@article{hulse2001-11180514,
  author  = {Hulse, R. E. and Winterfield, J. and Kunkler, P. E. and Kraig, R. P.},
  title   = {{Astrocytic clasmatodendrosis in hippocampal organ culture}},
  journal = {Glia},
  year    = {2001},
  doi     = {10.1002/1098-1136(200102)33:2<169::aid-glia1016>3.0.co;2-b},
  pmid    = {11180514},
  url     = {https://doi.org/10.1002/1098-1136(200102)33:2<169::aid-glia1016>3.0.co;2-b}
}

@article{gurwell2001-11226693,
  author  = {Gurwell, J. A. and Nath, A. and Sun, Q. and Zhang, J. and Martin, K. M. and Chen, Y. and Hauser, K. F.},
  title   = {{Synergistic neurotoxicity of opioids and human immunodeficiency virus-1 Tat protein in striatal neurons in vitro}},
  journal = {Neuroscience},
  year    = {2001},
  doi     = {10.1016/s0306-4522(00)00461-9},
  pmid    = {11226693},
  url     = {https://doi.org/10.1016/s0306-4522(00)00461-9}
}

@article{yehuda2001-11495096,
  author  = {Yehuda, R.},
  title   = {{Biology of posttraumatic stress disorder}},
  journal = {The Journal of clinical psychiatry},
  year    = {2001},
  pmid    = {11495096}
}

@article{takeuchi2000-11138929,
  author  = {Takeuchi, M. and Bucala, R. and Suzuki, T. and Ohkubo, T. and Yamazaki, M. and Koike, T. and Kameda, Y. and Makita, Z.},
  title   = {{Neurotoxicity of advanced glycation end-products for cultured cortical neurons}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2000},
  doi     = {10.1093/jnen/59.12.1094},
  pmid    = {11138929},
  url     = {https://doi.org/10.1093/jnen/59.12.1094}
}

@article{rizzini2000-11089577,
  author  = {Rizzini, C. and Goedert, M. and Hodges, JR. and Smith, M. J. and Jakes, R. and Hills, R. and Xuereb, J. H. and Crowther, R. A. and others},
  title   = {{Tau gene mutation K257T causes a tauopathy similar to Pick's disease}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2000},
  doi     = {10.1093/jnen/59.11.990},
  pmid    = {11089577},
  url     = {https://doi.org/10.1093/jnen/59.11.990}
}

@article{sapolsky2000-11015810,
  author  = {Sapolsky, R. M.},
  title   = {{Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders}},
  journal = {Archives of general psychiatry},
  year    = {2000},
  doi     = {10.1001/archpsyc.57.10.925},
  pmid    = {11015810},
  url     = {https://doi.org/10.1001/archpsyc.57.10.925}
}

@article{sapolsky2000-11063972,
  author  = {Sapolsky, R. M.},
  title   = {{The possibility of neurotoxicity in the hippocampus in major depression: a primer on neuron death}},
  journal = {Biological psychiatry},
  year    = {2000},
  doi     = {10.1016/s0006-3223(00)00971-9},
  pmid    = {11063972},
  url     = {https://doi.org/10.1016/s0006-3223(00)00971-9}
}

@article{stone2000-10964484,
  author  = {Stone, D. J. and Rozovsky, I. and Morgan, T. E. and Anderson, C. P. and Lopez, L. M. and Shick, J. and Finch, C. E.},
  title   = {{Effects of age on gene expression during estrogen-induced synaptic sprouting in the female rat}},
  journal = {Experimental neurology},
  year    = {2000},
  doi     = {10.1006/exnr.2000.7455},
  pmid    = {10964484},
  url     = {https://doi.org/10.1006/exnr.2000.7455}
}

@article{yamazaki2000-10901229,
  author  = {Yamazaki, M. and Arai, Y. and Baba, M. and Iwatsubo, T. and Mori, O. and Katayama, Y. and Oyanagi, K.},
  title   = {{Alpha-synuclein inclusions in amygdala in the brains of patients with the parkinsonism-dementia complex of Guam}},
  journal = {Journal of neuropathology and experimental neurology},
  year    = {2000},
  doi     = {10.1093/jnen/59.7.585},
  pmid    = {10901229},
  url     = {https://doi.org/10.1093/jnen/59.7.585}
}

@article{detoledomorrell2000-10911878,
  author  = {de Toledo-Morrell, L. and Goncharova, I. and Dickerson, B. and Wilson, R. S. and Bennett, D. A.},
  title   = {{From healthy aging to early Alzheimer's disease: in vivo detection of entorhinal cortex atrophy}},
  journal = {Annals of the New York Academy of Sciences},
  year    = {2000},
  doi     = {10.1111/j.1749-6632.2000.tb06730.x},
  pmid    = {10911878},
  url     = {https://doi.org/10.1111/j.1749-6632.2000.tb06730.x}
}

@article{joutel2000-10712431,
  author  = {Joutel, A. and Andreux, F. and Gaulis, S. and Domenga, V. and Cecillon, M. and Battail, N. and Piga, N. and Chapon, F. and others},
  title   = {{The ectodomain of the Notch3 receptor accumulates within the cerebrovasculature of CADASIL patients}},
  journal = {The Journal of clinical investigation},
  year    = {2000},
  doi     = {10.1172/jci8047},
  pmid    = {10712431},
  url     = {https://doi.org/10.1172/jci8047}
}

@article{klein2000-11041281,
  author  = {Klein, J.},
  title   = {{Membrane breakdown in acute and chronic neurodegeneration: focus on choline-containing phospholipids}},
  journal = {Journal of neural transmission (Vienna, Austria : 1996)},
  year    = {2000},
  doi     = {10.1007/s007020070051},
  pmid    = {11041281},
  url     = {https://doi.org/10.1007/s007020070051}
}

@article{hasel1999-10596928,
  author  = {Hasel, K. M. and Summers, B. A. and De Lahunta, A.},
  title   = {{Encephalopathy with idiopathic hyperammonaemia and Alzheimer type II astrocytes in equidae}},
  journal = {Equine veterinary journal},
  year    = {1999},
  doi     = {10.1111/j.2042-3306.1999.tb03854.x},
  pmid    = {10596928},
  url     = {https://doi.org/10.1111/j.2042-3306.1999.tb03854.x}
}

@article{seidman1999-10509177,
  author  = {Seidman, L. J. and Faraone, S. V. and Goldstein, J. M. and Goodman, J. M. and Kremen, W. S. and Toomey, R. and Tourville, J. and Kennedy, D. and others},
  title   = {{Thalamic and amygdala-hippocampal volume reductions in first-degree relatives of patients with schizophrenia: an MRI-based morphometric analysis}},
  journal = {Biological psychiatry},
  year    = {1999},
  doi     = {10.1016/s0006-3223(99)00075-x},
  pmid    = {10509177},
  url     = {https://doi.org/10.1016/s0006-3223(99)00075-x}
}

@article{parsons1999-10465680,
  author  = {Parsons, C. G. and Danysz, W. and Quack, G.},
  title   = {{Memantine is a clinically well tolerated N-methyl-D-aspartate (NMDA) receptor antagonist--a review of preclinical data}},
  journal = {Neuropharmacology},
  year    = {1999},
  doi     = {10.1016/s0028-3908(99)00019-2},
  pmid    = {10465680},
  url     = {https://doi.org/10.1016/s0028-3908(99)00019-2}
}

@article{janke1999-10320789,
  author  = {Janke, C. and Beck, M. and Stahl, T. and Holzer, M. and Brauer, K. and Bigl, V. and Arendt, T.},
  title   = {{Phylogenetic diversity of the expression of the microtubule-associated protein tau: implications for neurodegenerative disorders}},
  journal = {Brain research. Molecular brain research},
  year    = {1999},
  doi     = {10.1016/s0169-328x(99)00079-0},
  pmid    = {10320789},
  url     = {https://doi.org/10.1016/s0169-328x(99)00079-0}
}

@article{debellis1999-10349033,
  author  = {De Bellis, M. D. and Keshavan, M. S. and Clark, D. B. and Casey, B. J. and Giedd, J. N. and Boring, A. M. and Frustaci, K. and Ryan, N. D.},
  title   = {{A.E. Bennett Research Award. Developmental traumatology. Part II: Brain development}},
  journal = {Biological psychiatry},
  year    = {1999},
  doi     = {10.1016/s0006-3223(99)00045-1},
  pmid    = {10349033},
  url     = {https://doi.org/10.1016/s0006-3223(99)00045-1}
}

@article{schmidt1999-10082470,
  author  = {Schmidt, A. M. and Yan, S. D. and Wautier, J. L. and Stern, D.},
  title   = {{Activation of receptor for advanced glycation end products: a mechanism for chronic vascular dysfunction in diabetic vasculopathy and atherosclerosis}},
  journal = {Circulation research},
  year    = {1999},
  doi     = {10.1161/01.res.84.5.489},
  pmid    = {10082470},
  url     = {https://doi.org/10.1161/01.res.84.5.489}
}

@article{galea1999-10199627,
  author  = {Galea, L. A. and McEwen, B. S.},
  title   = {{Sex and seasonal differences in the rate of cell proliferation in the dentate gyrus of adult wild meadow voles}},
  journal = {Neuroscience},
  year    = {1999},
  doi     = {10.1016/s0306-4522(98)00345-5},
  pmid    = {10199627},
  url     = {https://doi.org/10.1016/s0306-4522(98)00345-5}
}

@article{doble1999-10334661,
  author  = {Doble, A.},
  title   = {{The role of excitotoxicity in neurodegenerative disease: implications for therapy}},
  journal = {Pharmacology \& therapeutics},
  year    = {1999},
  doi     = {10.1016/s0163-7258(98)00042-4},
  pmid    = {10334661},
  url     = {https://doi.org/10.1016/s0163-7258(98)00042-4}
}

@article{iijima1999-10208578,
  author  = {Iijima, M. and Tabira, T. and Poorkaj, P. and Schellenberg, G. D. and Trojanowski, J. Q. and Lee, V. M. and Schmidt, M. L. and Takahashi, K. and others},
  title   = {{A distinct familial presenile dementia with a novel missense mutation in the tau gene}},
  journal = {Neuroreport},
  year    = {1999},
  doi     = {10.1097/00001756-199902250-00010},
  pmid    = {10208578},
  url     = {https://doi.org/10.1097/00001756-199902250-00010}
}

@article{labudova1999-10210286,
  author  = {Labudova, O. and Cairns, N. and Koeck, T. and Kitzmueller, E. and Rink, H. and Lubec, G.},
  title   = {{Thyroid stimulating hormone-receptor overexpression in brain of patients with Down syndrome and Alzheimer's disease}},
  journal = {Life sciences},
  year    = {1999},
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  doi     = {10.1016/j.bpj.2025.08.010},
  pmid    = {40817583},
  url     = {https://doi.org/10.1016/j.bpj.2025.08.010}
}

@article{mercado2025-1839cdb4,
  author  = {Mercado, Francisco and Kop, Michaela and Trinh, Michelle},
  title   = {{GLP-1 receptor agonists in delirium and encephalopathies: a neuroprotective scoping review}},
  journal = {Discover Medicine},
  year    = {2025},
  doi     = {10.1007/s44337-025-00428-0},
  url     = {https://doi.org/10.1007/s44337-025-00428-0}
}

@article{schrader2025-40683561,
  author  = {Schrader, Joseph M. and Xu, Feng and Zhu, Xiaoyue and Majchrzak, Mark J. and Davis, Judianne and Van Nostrand, William E.},
  title   = {{Parenchymal and Dyshoric Fibrillar Amyloid Pathology in the rTg-D Rat Model of Cerebral Amyloid Angiopathy Type-2}},
  journal = {American Journal Of Pathology},
  year    = {2025},
  doi     = {10.1016/j.ajpath.2025.06.008},
  pmid    = {40683561},
  url     = {https://doi.org/10.1016/j.ajpath.2025.06.008}
}

@article{schwartz2025-40584633,
  author  = {Schwartz, Nicholas U. and Dietz, Connor D. and Araújo, Igor Prufer and Villanueva-Meyer, Javier E. and Chiong, Winston and Lane‐Donovan, Courtney and VandeVrede, Lawren A. and Ljubenkov, Peter Alexander and others},
  title   = {{Changes of a Cerebral Cavernous Malformation Associated With Lecanemab Therapy in a Patient With Alzheimer Disease}},
  journal = {Neurology Clinical Practice},
  year    = {2025},
  doi     = {10.1212/cpj.0000000000200508},
  pmid    = {40584633},
  url     = {https://doi.org/10.1212/cpj.0000000000200508}
}

@article{tzekaki2025-40427737,
  author  = {Tzekaki, Elena E. and Katsipis, Georgios and Chatzikostopoulos, Athanasios and Koutoupa, Anna and Lavrentiadou, Sophia N. and Tsolaki, Magda and Pantazaki, Αnastasia A.},
  title   = {{Neuroprotective, Antioxidant and Anti-Inflammatory Effect of Greek Pomegranate Seed Oil on N2a Neuroblastoma Cells and Mild Cognitive Impairment Patients}},
  journal = {Biology},
  year    = {2025},
  doi     = {10.3390/biology14050548},
  pmid    = {40427737},
  url     = {https://doi.org/10.3390/biology14050548}
}

@article{marongiu2025-40438709,
  author  = {Marongiu, Roberta and Platholi, Jimcy and Park, Laibaik and Yu, Fangmin and Sommer, Garrett and Woods, Clara and Milner, Teresa A. and Glass, Michael J.},
  title   = {{Promotion of neuroinflammation in select hippocampal regions in a mouse model of perimenopausal Alzheimer’s disease}},
  journal = {Frontiers in Molecular Biosciences},
  year    = {2025},
  doi     = {10.3389/fmolb.2025.1597130},
  pmid    = {40438709},
  url     = {https://doi.org/10.3389/fmolb.2025.1597130}
}

@article{bianchini2025-40231522,
  author  = {Bianchini, Matheus Chimelo and Franscescon, Francini and Soares, Adinei Abadio and Ansolin, Vinicius and Pretto, Kailane Paula and da Cunha, Marcelo Lemos Vieira and Silva, Débora Tavares de Resende e},
  title   = {{Potential Benefits of Quercetin through P2X7 Modulation against Neuroinflammation in Alzheimer's Disease}},
  journal = {Current Neuropharmacology},
  year    = {2025},
  doi     = {10.2174/011570159x355614250130100132},
  pmid    = {40231522},
  url     = {https://doi.org/10.2174/011570159x355614250130100132}
}

@article{scialo2025-40157355,
  author  = {Scialò, Carlo and Zhong, Weijia and Jagannath, Somanath and Wilkins, Oscar G. and Caredio, Davide and Hruška-Plocháň, Marián and Lurati, Flavio and Peter, Martina and others},
  title   = {{Seeded aggregation of TDP-43 induces its loss of function and reveals early pathological signatures}},
  journal = {Neuron},
  year    = {2025},
  doi     = {10.1016/j.neuron.2025.03.008},
  pmid    = {40157355},
  url     = {https://doi.org/10.1016/j.neuron.2025.03.008}
}

@article{shahidehpour2025-40042444,
  author  = {Shahidehpour, Ryan K. and Nelson, Peter T. and Srinivasan, Sukanya and Zhong, Yu and Bachstetter, Adam D.},
  title   = {{Assessing Co‐Localization of ITM2B With Alzheimer's Disease and Limbic‐Predominant Age‐Related TDP ‐43 Encephalopathy Neuropathologic Changes}},
  journal = {Neuropathology},
  year    = {2025},
  doi     = {10.1111/neup.70003},
  pmid    = {40042444},
  url     = {https://doi.org/10.1111/neup.70003}
}

@article{salama2025-ba0980c1,
  author  = {Salama, Abeer and Mohasib, Rasha M.M. and Shalaby, Eman Samy},
  title   = {{Neuroprotective role of Origanum majorana essential oil loaded in mixed surfactants based nano emulsion against lipopolysaccharide-induced Alzheimer in mice}},
  journal = {Journal of Pharmaceutical Investigation},
  year    = {2025},
  doi     = {10.1007/s40005-024-00696-5},
  url     = {https://doi.org/10.1007/s40005-024-00696-5}
}

@article{richardson2025-39994734,
  author  = {Richardson, Tyrique and Hou, Xu and Fiesel, Fabienne C. and Wszołek, Zbigniew K. and Dickson, Dennis W. and Springer, Wolfdieter},
  title   = {{Hippocampal mitophagy alterations in MAPT-associated frontotemporal dementia with parkinsonism}},
  journal = {Acta Neuropathologica Communications},
  year    = {2025},
  doi     = {10.1186/s40478-025-01955-8},
  pmid    = {39994734},
  url     = {https://doi.org/10.1186/s40478-025-01955-8}
}

@article{cantone2025-39918606,
  author  = {Cantone, Anna Flavia and Burgaletto, Chiara and Di Benedetto, Giulia and Gaudio, Gabriella and Giallongo, Cesarina and Caltabiano, Rosario and Broggi, Giuseppe and Bellanca, Carlo Maria and others},
  title   = {{Rebalancing Immune Interactions within the Brain-Spleen Axis Mitigates Neuroinflammation in an Aging Mouse Model of Alzheimer’s Disease}},
  journal = {Journal of Neuroimmune Pharmacology},
  year    = {2025},
  doi     = {10.1007/s11481-025-10177-7},
  pmid    = {39918606},
  url     = {https://doi.org/10.1007/s11481-025-10177-7}
}

@article{chami2025-39778789,
  author  = {Chami, Anna A. and Gravel, Claude and Weng, Yuan Cheng and Križ, Jasna and Julien, Jean-Pierre},
  title   = {{Virus-mediated delivery of single-chain antibody targeting TDP-43 protects against neuropathology, cognitive impairment and motor deficit caused by chronic cerebral hypoperfusion}},
  journal = {Experimental Neurology},
  year    = {2025},
  doi     = {10.1016/j.expneurol.2025.115138},
  pmid    = {39778789},
  url     = {https://doi.org/10.1016/j.expneurol.2025.115138}
}

@article{cuello2025-40340070,
  author  = {Cuello, A. C. and Do Carmo, S.},
  title   = {{The dependence of basal forebrain cholinergic neurons on NGF: The case in Alzheimer pathology}},
  journal = {Handbook of clinical neurology},
  year    = {2025},
  doi     = {10.1016/b978-0-443-19088-9.00010-x},
  pmid    = {40340070},
  url     = {https://doi.org/10.1016/b978-0-443-19088-9.00010-x}
}

@article{park2025-40856064,
  author  = {Park, Joon Hyuk and Yang, Hyun Ju and Park, Suyeon and Kim, Bong Soo},
  title   = {{Greater White Matter Hyperintensities and More Severe Cognitive Dysfunction in Mild Cognitive Impairment With Motoric Cognitive Risk Syndrome}},
  journal = {Journal of Korean Medical Science},
  year    = {2025},
  doi     = {10.3346/jkms.2025.40.e200},
  pmid    = {40856064},
  url     = {https://doi.org/10.3346/jkms.2025.40.e200}
}

@article{azimzadeh2024-39307112,
  author  = {Azimzadeh, M. and Cheah, P. S. and Ling, K. H.},
  title   = {{Brain insulin resistance in Down syndrome: Involvement of PI3K-Akt/mTOR axis in early-onset of Alzheimer's disease and its potential as a therapeutic target}},
  journal = {Biochemical and biophysical research communications},
  year    = {2024},
  doi     = {10.1016/j.bbrc.2024.150713},
  pmid    = {39307112},
  url     = {https://doi.org/10.1016/j.bbrc.2024.150713}
}

@article{lindsay2024-38663907,
  author  = {Lindsay, Pett and Zhenjiang, Li and Sarina, Abrishamcar and Kenyaita, Hodge and Todd, Everson and Grace, Christensen and Marla, Gearing and Kobor Michael, S. and others},
  title   = {{The association between neighborhood deprivation and DNA methylation in an autopsy cohort}},
  journal = {Aging},
  year    = {2024},
  doi     = {10.18632/aging.205764},
  pmid    = {38663907},
  url     = {https://doi.org/10.18632/aging.205764}
}

@article{deng2024-38604526,
  author  = {Deng, J. and Liu, B. and Tao, Q. and Luo, Y. and Zhu, Y. and Huang, X. and Yue, F.},
  title   = {{The Co-oligomers of Aβ42 and Human Islet Amyloid Polypeptide Exacerbate Neurotoxicity and Alzheimer-like Pathology at Cellular Level}},
  journal = {Neuroscience},
  year    = {2024},
  doi     = {10.1016/j.neuroscience.2024.04.002},
  pmid    = {38604526},
  url     = {https://doi.org/10.1016/j.neuroscience.2024.04.002}
}

@article{bernstein2023-37524128,
  author  = {Bernstein, H. G. and Smalla, K. H. and Keilhoff, G. and Dobrowolny, H. and Kreutz, M. R. and Steiner, J.},
  title   = {{The many "Neurofaces" of Prohibitins 1 and 2: Crucial for the healthy brain, dysregulated in numerous brain disorders}},
  journal = {Journal of chemical neuroanatomy},
  year    = {2023},
  doi     = {10.1016/j.jchemneu.2023.102321},
  pmid    = {37524128},
  url     = {https://doi.org/10.1016/j.jchemneu.2023.102321}
}

@article{ganguly2023-36371073,
  author  = {Ganguly, B. B. and Kadam, N. N.},
  title   = {{Therapeutics for mitochondrial dysfunction-linked diseases in Down syndrome}},
  journal = {Mitochondrion},
  year    = {2023},
  doi     = {10.1016/j.mito.2022.11.003},
  pmid    = {36371073},
  url     = {https://doi.org/10.1016/j.mito.2022.11.003}
}

@article{hoilundcarlsen2022-35452007,
  author  = {Høilund-Carlsen, P. F. and Werner, T. J. and Alavi, A. and Revheim, M. E.},
  title   = {{Aducanumab-Related Amyloid-Related Imaging Abnormalities: Paean or Lament?}},
  journal = {Clinical nuclear medicine},
  year    = {2022},
  doi     = {10.1097/rlu.0000000000004250},
  pmid    = {35452007},
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@article{grossberg2021-35822037,
  author  = {Grossberg, A. N. and Bettcher, B. M. and Gorgens, K. A. and Ledreux, A.},
  title   = {{Curiosity-Based Interventions Increase Everyday Functioning Score But Not Serum BDNF Levels in a Cohort of Healthy Older Adults}},
  journal = {Frontiers in aging},
  year    = {2021},
  doi     = {10.3389/fragi.2021.700838},
  pmid    = {35822037},
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@article{wei2020-32854771,
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  title   = {{Prenatal to early postnatal neurotrophic treatment prevents Alzheimer-like behavior and pathology in mice}},
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  year    = {2020},
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@article{wang2020-31997558,
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  journal = {Brain and behavior},
  year    = {2020},
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@article{zafeer2019-31029786,
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  title   = {{Prolong treatment with Trans-ferulic acid mitigates bioenergetics loss and restores mitochondrial dynamics in streptozotocin-induced sporadic dementia of Alzheimer's type}},
  journal = {Neurotoxicology},
  year    = {2019},
  doi     = {10.1016/j.neuro.2019.04.006},
  pmid    = {31029786},
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@article{yang2018-30273629,
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  title   = {{Fluoride activates microglia, secretes inflammatory factors and influences synaptic neuron plasticity in the hippocampus of rats}},
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  year    = {2018},
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@article{diaz2018-30154946,
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  title   = {{Metabolic Syndrome Exacerbates the Recognition Memory Impairment and Oxidative-Inflammatory Response in Rats with an Intrahippocampal Injection of Amyloid Beta 1-42}},
  journal = {Oxidative medicine and cellular longevity},
  year    = {2018},
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@article{heide2017-28318110,
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  title   = {{On the association analysis of genome-sequencing data: A spatial clustering approach for partitioning the entire genome into nonoverlapping windows}},
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  title   = {{Longitudinal noninvasive magnetic resonance imaging of brain microhemorrhages in BACE inhibitor-treated APP transgenic mice}},
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  year    = {2016},
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@article{shen2015-25890254,
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  year    = {2015},
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@article{chohan2015-25255260,
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  title   = {{Enhancement of neurogenesis and memory by a neurotrophic peptide in mild to moderate traumatic brain injury}},
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@article{ringseis2015-25825956,
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@article{karlsen2014-25220902,
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  title   = {{A stereological study of the mediodorsal thalamic nucleus in Down syndrome}},
  journal = {Neuroscience},
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@article{muchova2014-24908086,
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@article{kirby2011-21992352,
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@article{schaeffer2011-21387172,
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  year    = {2011},
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@article{leoni2009-19199127,
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@article{yoo2007-17221321,
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@article{desimone2006-16987746,
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  year    = {2006},
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  title   = {{Extracellular deposits of A beta produced in cultures of Alzheimer disease brain vascular smooth muscle cells}},
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  journal = {Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis},
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@article{bernstein2003-14707550,
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  year    = {2003},
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@article{seidl2001-11417611,
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  title   = {{Evidence for apoptosis in the fetal Down syndrome brain}},
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  year    = {2001},
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  pmid    = {11417611},
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  title   = {{Unaltered expression of Fas (CD95/APO-1), caspase-3, Bcl-2 and annexins in brains of fetal Down syndrome: evidence against increased apoptosis}},
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  pmid    = {11771740},
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@article{ferrer2000-10837922,
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@article{tu2026-42434904,
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@article{meng2026-42108759,
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@article{zhu2026-41578175,
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  title   = {{Cognitive–exercise dual-task training delays natural aging/d-galactose-induced cognitive decline in mice}},
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@article{patel2026-41560705,
  author  = {Patel, Prachetas Jai and Yan, Zhen},
  title   = {{Epigenomic aberrations of histone methylation in prefrontal cortex of humans with mild cognitive impairment and Alzheimer's disease}},
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  year    = {2026},
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@article{huang2026-41665027,
  author  = {Huang, Sufen and Bei, Yuzhang and Zhang, Qingxiang and Nan, Haitian and Li, Junjie},
  title   = {{Behavioral Variant Frontotemporal Dementia With C9orf72 Intermediate Repeat Expansion}},
  journal = {Alzheimer Disease \& Associated Disorders},
  year    = {2026},
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@article{nelson2025-41433690,
  author  = {Nelson, Heather A. and La’ulu, Sonia L. and Erickson, J. Alan and Cunningham, Sierra and Doyle, Kelly J.},
  title   = {{Clinical validation of a plasma p ‐tau217 immunoassay and evaluation of the impact of kidney function}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70861_108683},
  pmid    = {41433690},
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}

@article{ruhela2025-41447294,
  author  = {Ruhela, Vivek and Cieza, Basilio and Mayeux, Richard P and Reyes‐Dumeyer, Dolly and Teich, Andrew F. and Tosto, Giuseppe},
  title   = {{Genetic Colocalization of Expression Quantitative Trait Loci (eQTL) Mapping and GWAS in a multiethnic brain bank: An Insight into ancestry‐specific Regulatory Architecture in Alzheimer's disease}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70855_107199},
  pmid    = {41447294},
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}

@article{polydoro2025-41447159,
  author  = {Polydoro, Manuela and Geric, Ivana and Zheng, Jin and Bisgaard, Tina Sommer and Comer, Ashley L. and Sans, Laura and Lu, Ashley and Vilstrup, Joachim and others},
  title   = {{A Novel TREM2 Small Molecule Agonist MTX46943 Re‐Programs Human Microglia and Reduces Amyloid Pathology In Vivo}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
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  pmid    = {41447159},
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@article{shenouda2025-41447225,
  author  = {Shenouda, Marc and Robertson, Janice},
  title   = {{Small Molecule Targeting of Chaperone IP Protein Prevents and Reverses TDP‐43 Aggregation In‐vitro and In‐vivo}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70859_099984},
  pmid    = {41447225},
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@article{heimfarth2025-41439604,
  author  = {Heimfarth, Luana and Ribeiro, Felipe Campos and Fortuna, Juliana T S and Stelzer, Gustavo Trevizani and Ferreira, Sergio Teixeira},
  title   = {{Irisin attenuates astrocyte activation and rescues memory in Alzheimer model mice}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70855_104063},
  pmid    = {41439604},
  url     = {https://doi.org/10.1002/alz70855_104063}
}

@article{dannert2025-41452866,
  author  = {Dannert, Angelika},
  title   = {{A human iPSC model of Tauopathies engineered for 4R Tau isoform expression endogenously develops late‐stage neuronal Tau pathology}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70855_100354},
  pmid    = {41452866},
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}

@article{spyropoulos2025-41445252,
  author  = {Spyropoulos, Demetri D. and Jenkins, Dorea P. and Carroll, Steven Lewis},
  title   = {{Mice with pR927Q and pI712M Erbb4 Mutations Develop Features of Frontotemporal Dementia and ALS}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70855_106736},
  pmid    = {41445252},
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@article{keszycki2025-41446915,
  author  = {Keszycki, Rachel M. and Ayala, Ivan and Zouridakis, Antonia and Kawles, Allegra and Macomber, Alyssa and Nelson, Caroline M and Minogue, Grace and Weıntraub, Sandra and others},
  title   = {{Amygdala nuclei are not uniformly vulnerable to FTLD‐tauopathies in PPA}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70855_107447},
  pmid    = {41446915},
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@article{stocks2025-41447155,
  author  = {Stocks, Jane K. and Keszycki, Rachel M. and Gutstein, Daniel and Parrish, Todd and Castellani, Rudolph J. and Geula, Changiz and Barbieri, Elena and Weıntraub, Sandra and others},
  title   = {{Amygdala parcellation reveals unique subregions of atrophy in FTLD‐tauopathies}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70856_100335},
  pmid    = {41447155},
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@article{stocks2025-41434382,
  author  = {Stocks, Jane K. and Keszycki, Rachel M. and Gutstein, Daniel and Parrish, Todd B. and Castellani, Rudolph J. and Geula, Changiz and Barbieri, Elena and Weıntraub, Sandra and others},
  title   = {{Amygdala parcellation reveals unique subregions of atrophy in FTLD‐tauopathies}},
  journal = {Alzheimer s \& Dementia},
  year    = {2025},
  doi     = {10.1002/alz70862_109842},
  pmid    = {41434382},
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@article{xing2025-41322351,
  author  = {Xing, Hang and Hu, Wen-Long and Bao, Sheng-yong},
  title   = {{Acupuncture modulates the microbiota-gut-brain axis: a novel therapeutic strategy for amnestic mild cognitive impairment}},
  journal = {Frontiers in Neuroscience},
  year    = {2025},
  doi     = {10.3389/fnins.2025.1710066},
  pmid    = {41322351},
  url     = {https://doi.org/10.3389/fnins.2025.1710066}
}

@article{feng2025-41229080,
  author  = {Feng, Mengmeng and Wang, Yuan and Liu, Xiaoyi and Zhang, Senhao and Lu, Weizhao and Wang, Tao and Song, Haiqing and Lu, Jie},
  title   = {{Increased iron deposition in putamen and substantia nigra correlates with cognitive function in cerebral small vessel disease: A quantitative susceptibility mapping study}},
  journal = {Journal of Cerebral Blood Flow \& Metabolism},
  year    = {2025},
  doi     = {10.1177/0271678x251377569},
  pmid    = {41229080},
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@article{shaw2025-41191004,
  author  = {Shaw, Benjamin C. F. and Kaiser, Kaitlin E. and Smith, Brandon C. and Timken, J Payton and Louveau, Antoine and Williams, Jessica Lynn},
  title   = {{Astrocytes upregulate interleukin-15 in response to neuroinflammation during Alzheimer's disease}},
  journal = {Journal of Alzheimer s Disease},
  year    = {2025},
  doi     = {10.1177/13872877251393275},
  pmid    = {41191004},
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}

@article{acero2025-40906020,
  author  = {Acero, Gonzalo and Rodríguez-López, Adrián and Díaz, Georgina and Esteban, Daniel and Herrera-Ángeles, Mónica and Gevorkian, Goar},
  title   = {{Splenomegaly, Spleen Amyloidosis and Neutrophil Infiltration are Present in 3xTg-AD, but not Tg-SwDI Mice}},
  journal = {NeuroMolecular Medicine},
  year    = {2025},
  doi     = {10.1007/s12017-025-08884-8},
  pmid    = {40906020},
  url     = {https://doi.org/10.1007/s12017-025-08884-8}
}

@article{dave2025-41018303,
  author  = {Dave, Mili and Le, Peter},
  title   = {{Rapidly Progressive Dementia After Platelet-Rich Plasma Therapy: A Case of Sporadic Creutzfeldt-Jakob Disease in the Context of Chronic Ehrlichiosis}},
  journal = {Cureus},
  year    = {2025},
  doi     = {10.7759/cureus.91152},
  pmid    = {41018303},
  url     = {https://doi.org/10.7759/cureus.91152}
}

@article{du2025-40933048,
  author  = {Du, Lin and Wang, Lieping and Shen, Gang and Zeng, Min and Li, Desheng and Li, Weiguo},
  title   = {{Progress of radiomics research on white matter hyperintensity lesions}},
  journal = {Frontiers in Neurology},
  year    = {2025},
  doi     = {10.3389/fneur.2025.1647724},
  pmid    = {40933048},
  url     = {https://doi.org/10.3389/fneur.2025.1647724}
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@article{tang2025-40329537,
  author  = {Tang, Shizhen and Liu, Shihan and Buchman, Aron S. and Bennett, David Alan and De Jager, Philip L. and Yang, Jingjing and Hu, Jian},
  title   = {{Integrating spatial transcriptomics and snRNA-seq data enhances differential gene expression analysis results of AD-related phenotypes}},
  journal = {Human Genetics and Genomics Advances},
  year    = {2025},
  doi     = {10.1016/j.xhgg.2025.100447},
  pmid    = {40329537},
  url     = {https://doi.org/10.1016/j.xhgg.2025.100447}
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@article{nietobenito2025-40204134,
  author  = {Nieto-Benito, L. M. and Suárez-Fernández, R.},
  title   = {{Unraveling the Link Between Bullous Pemphigoid and Neurological Disease: A Single-center Study of 257 Patients}},
  journal = {Actas dermo-sifiliograficas},
  year    = {2025},
  doi     = {10.1016/j.ad.2024.10.071},
  pmid    = {40204134},
  url     = {https://doi.org/10.1016/j.ad.2024.10.071}
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@article{rullmann2025-2ee7545f,
  author  = {Rullmann, Michael and Tiepolt, Solveig and Willmer, F. and Peppert, F and Brendel, Matthias and Gnörich, Johannes S. and Schroeter, Matthias Leopold and Saur, Dorothee and others},
  title   = {{Perfusionsmuster der [18F]PI-2620-Tau-PET bei verschiedenen neurodegenerativen Tauopathien}},
  journal = {Nuklearmedizin - NuclearMedicine},
  year    = {2025},
  doi     = {10.1055/s-0045-1804306},
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@article{anderson2025-39864404,
  author  = {Anderson, Ashley N. and Dopler, Matthew B and Arezoumandan, Sanaz and Osei‐KanKam, Damian and Davis, Stephani A. and Ajroud, Kaouther and Lilek, Jaclyn N and Bambakadis, Eva and others},
  title   = {{Cytoplasmic expression of trans-active response DNA-binding protein-43 in aged mice display hippocampal sclerosis-like degeneration and neuronal loss with reduced lifespan}},
  journal = {Journal of Neuropathology \& Experimental Neurology},
  year    = {2025},
  doi     = {10.1093/jnen/nlae137},
  pmid    = {39864404},
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@article{wan2025-39791204,
  author  = {Wan, Tianchi and Wang, Chunkai},
  title   = {{SMOC2 promotes microglia activity and neuroinflammation in Alzheimer's disease}},
  journal = {Journal of Alzheimer s Disease},
  year    = {2025},
  doi     = {10.1177/13872877241307337},
  pmid    = {39791204},
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@article{sisman2025-40476457,
  author  = {Şişman, Aysel Büşra and Merve, Savaş and Koral, Gizem and Bayar, Muhammet Duran and Yildiz, Oğuz and Mutlu, Aytül and Yılmaz, Vuslat and Tüzün, Erdem and others},
  title   = {{Treatment-resistant patients with focal epilepsy of unknown cause display reduced neurogranin levels: a preliminary study}},
  journal = {Ideggyógyászati Szemle},
  year    = {2025},
  doi     = {10.18071/isz.78.0163},
  pmid    = {40476457},
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@article{perry2024-39127343,
  author  = {Perry, J. C. and Vann, S. D.},
  title   = {{Reduction in neurons immunoreactive for calcium-binding proteins in the anteroventral thalamic nuclei of individuals with Down syndrome}},
  journal = {Neuroscience},
  year    = {2024},
  doi     = {10.1016/j.neuroscience.2024.08.004},
  pmid    = {39127343},
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@article{deleeuw2022-34919811,
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  title   = {{APOE2, E3, and E4 differentially modulate cellular homeostasis, cholesterol metabolism, and inflammatory response in isogenic iPSC-derived astrocytes}},
  journal = {Stem cell reports},
  year    = {2022},
  doi     = {10.1016/j.stemcr.2021.11.007},
  pmid    = {34919811},
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@article{mengr2021-34551697,
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  title   = {{Palmitoylated Prolactin-releasing Peptide Reduced Aβ Plaques and Microgliosis in the Cerebellum: APP/PS1 Mice Study}},
  journal = {Current Alzheimer research},
  year    = {2021},
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@article{arai2019-30086988,
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  title   = {{Elimination of amyloid precursor protein in senile plaques in the brain of a patient with Alzheimer-type dementia and Down syndrome}},
  journal = {Brain \& development},
  year    = {2019},
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@article{vargasrestrepo2018-29809330,
  author  = {Vargas-Restrepo, F. and Sabogal-Guáqueta, A. M. and Cardona-Gómez, G. P.},
  title   = {{[Quercetin ameliorates inflammation in CA1 hippocampal region in aged triple transgenic Alzheimer´s disease mice model.]}},
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  year    = {2018},
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  title   = {{Classification of tauopathies from human brain homogenates through salt-modulated tau amplification}},
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  title   = {{Deposition of aggregated cystatin C-amyloid-β complexes and reduced cathepsin B activity modulate cerebral amyloid angiopathy pathogenesis}},
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  title   = {{Retinal vessel density using optical coherence tomography angiography as a potential biomarker in patients with cerebral small vessel disease}},
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@article{paolillo2026-7ef6cdb9,
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  title   = {{Smartphone Passive Digital Phenotyping in Frontotemporal Lobar Degeneration}},
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@article{zhao2026-a7c7238d,
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  title   = {{Genetically Predicted Blood DNA Methylation Reveals Putative Regulatory Signals Associated with ALS Risk}},
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@article{ma2026-a6a56bb0,
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  title   = {{Varenicline as a Repurposable Drug Candidate for ADRD Prevention}},
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@article{tan2026-e830449b,
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  title   = {{Myo-inositol as a spectroscopic marker of neuroinflammation in frontotemporal lobar degeneration}},
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@article{rash2026-3d07c8bf,
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  title   = {{Laromestrocel preserves brain volume and cognitive function in Alzheimers disease by inhibiting neuroinflammation}},
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@article{du2026-54b6b226,
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  title   = {{Development and External Validation of a Plasma p-tau217-Based Model for MCI-to-Dementia Progression}},
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@article{karim2026-9885f5da,
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  title   = {{Down syndrome postmortem brains exhibit reduction in [ 18 F]nifene binding to α4β2* nicotinic acetylcholinergic receptors}},
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@article{yang2026-a81a35f6,
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  title   = {{The APOL1 protective M1 modifier occurs exclusively with the KIK protein haplotype to suppress channel conductance}},
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@article{ono2026-f0890d90,
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  title   = {{Diagnostic Value of Large Language Model-Extracted Gross Brain Findings in Neurodegenerative Diseases}},
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@article{daoust2026-6c3e8264,
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  title   = {{Pathway-specific polygenic risk scores reveal underlying mechanisms of cerebral small vessel disease}},
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@article{wang2026-94ee023c,
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  title   = {{Serum Brain-Derived Neurotrophic Factor Across the Human Lifespan: A Systematic Review and Meta-Analysis}},
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@article{moqadam2026-8c3654ac,
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  title   = {{Vascular and neurodegenerative contributions to cognitive decline and multidomain progression in de novo Parkinsons disease}},
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  year    = {2026},
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@article{baumel2026-f0e62b39,
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  title   = {{Amyloid-Independent Elevation of Plasma phosphorylated tau-217 Tracks Neurodegenerative Risk in Tuberous Sclerosis Complex: Implications for mTOR-Targeted Intervention}},
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@article{kuik2026-fb8d9249,
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  title   = {{Effects of sex, treatment resistance, and antidepressant treatment on monoamine oxidase B total distribution volume}},
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  year    = {2026},
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@article{javidnia2026-df90200c,
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  year    = {2026},
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}

@article{liu2026-47e80dff,
  author  = {Liu, T. and Ko, E. and Yang, Y. and Wu, H. and Unjitwattana, T. and Wang, S. and Kang, J. and Li and others},
  title   = {{Population-Scale Integration of Spatial Omics Networks for Clinical Prediction and Biological Discovery by SPIN}},
  journal = {medRxiv (preprint)},
  year    = {2026},
  doi     = {10.1101/2025.08.09.25333297},
  url     = {https://doi.org/10.1101/2025.08.09.25333297}
}

@article{cheng2026-ba023161,
  author  = {Cheng, Z. and Judaprawira, S. and Perez, J. and Goldstein, A.},
  title   = {{Sex-aware Cross-tissue Regulatory Transformer Identified Sexually Dimorphic Alzheimer's Disease Risk Loci and Causal Cellular Circuit}},
  journal = {medRxiv (preprint)},
  year    = {2026},
  doi     = {10.64898/2026.09.08.26362488},
  url     = {https://doi.org/10.64898/2026.09.08.26362488}
}

@article{cao2026-517396ca,
  author  = {Cao, X. and Sun, H. and Feng, R. and Mazumder, R. and Najar, C. F. B. A. and Li, Y. I. and De Jager, P. L. and Bennett and others},
  title   = {{Integrative multi-omics QTL colocalization maps regulatory architecture in aging human brain}},
  journal = {medRxiv (preprint)},
  year    = {2026},
  doi     = {10.1101/2025.04.17.25326042},
  url     = {https://doi.org/10.1101/2025.04.17.25326042}
}

@article{bernasconi2026-bb689293,
  author  = {Bernasconi, F. and Stampacchia, S. and Burget, L. and Potheegadoo, J. and Maradan, M. and Habiby Alaoui, S. and Catalano Chiuve, S. and De Ville, Van and others},
  title   = {{Dopaminergic therapy selectively amplifies hallucination susceptibility in patients with Parkinson's disease with cortico-striatal hyperconnectivity}},
  journal = {medRxiv (preprint)},
  year    = {2026},
  doi     = {10.64898/2026.09.01.26361921},
  url     = {https://doi.org/10.64898/2026.09.01.26361921}
}

@article{sadia2026-3b48aef7,
  author  = {Sadia, H. and Doyon, N. and Duchesne, S.},
  title   = {{External Validation of a Mathematical Model of Brain Health}},
  journal = {medRxiv (preprint)},
  year    = {2026},
  doi     = {10.64898/2026.09.01.26361929},
  url     = {https://doi.org/10.64898/2026.09.01.26361929}
}

@article{haskins2026-2ab27f16,
  author  = {Haskins, W. E. and Wang, K. K. and Cai, G. and Boukholda, K. and Elbayoumi, E. and Bajpai, R. and Jackson, D. and Tehas and others},
  title   = {{Proteoform-resolved neoGFAP as a diagnostic and prognostic biomarker across the TBI--MCI--AD continuum in Veterans}},
  journal = {medRxiv (preprint)},
  year    = {2026},
  doi     = {10.64898/2026.09.01.26361845},
  url     = {https://doi.org/10.64898/2026.09.01.26361845}
}

@article{langbaum2026-7a589453,
  author  = {Langbaum, J. B. and Erickson, C. M. and Langlois, C. and Wood, E. M. and Egleston, B. L. and Harkins, K. and Mim, R. and John and others},
  title   = {{Returning APOE and pTau-217 Results: the eSMARTER Randomized Noninferiority Clinical Trial}},
  journal = {medRxiv (preprint)},
  year    = {2026},
  doi     = {10.64898/2026.08.27.26361535},
  url     = {https://doi.org/10.64898/2026.08.27.26361535}
}

@article{raikes2026-16df6f75,
  author  = {Raikes, A. C. and Garza, M. and Tirambulo, C. V. G. and Murrell, A. N. and Brinton, R. D.},
  title   = {{Meta-analysis of glucose metabolism across Alzheimer's, Parkinson's and ALS reveals distinct patterns of cortical hypometabolism versus subcortical hypermetabolism with disease-specific spatial signatures}},
  journal = {medRxiv (preprint)},
  year    = {2026},
  doi     = {10.64898/2026.04.07.26350339},
  url     = {https://doi.org/10.64898/2026.04.07.26350339}
}

@article{martinaguilar2026-a46fba4d,
  author  = {Martin-Aguilar, L. and Gonzalez-Ortiz, F. and Zetterberg, H. and Karikari, T. K. and Suarez-Calvet, M. and Casasnovas, C. and Gutierrez-Gutierrez, G. and Sedano-Tous and others},
  title   = {{Big tau and brain-derived tau reveal peripheral and central nervous system involvement in neuropathies}},
  journal = {medRxiv (preprint)},
  year    = {2026},
  doi     = {10.64898/2026.08.27.26361202},
  url     = {https://doi.org/10.64898/2026.08.27.26361202}
}

@article{marti2026-32527300,
  author  = {Marti, M. B. and Morrison, S. D. and Pars, S. and Al-mhanawi, B. and Noakes, P. G. and Wolvetang, E. J. and Shaker, M. R.},
  title   = {{Oligodendrocyte Enriched Brain Organoids Reveal Impaired Oligodendroglial Maturation and Altered Neural Network Activity in Down Syndrome}},
  journal = {bioRxiv},
  year    = {2026},
  doi     = {10.64898/2026.08.27.747500},
  url     = {https://doi.org/10.64898/2026.08.27.747500}
}

@article{zheng2026-e4fc5f6b,
  author  = {Zheng, C. and Shivakumar, M. and Shen, L. and Kim, D.},
  title   = {{Absorption and Co-expression Modules Show Where Polygenic and Proteomic Risk Scores Diverge in Neurodegenerative Diseases}},
  journal = {medRxiv (preprint)},
  year    = {2026},
  doi     = {10.64898/2026.08.24.26361271},
  url     = {https://doi.org/10.64898/2026.08.24.26361271}
}

@article{weightman2026-f57e2efc,
  author  = {Weightman, M. and Robinson, B. and Smyth, H. and Pick, A. and Martin, E. and Walsh, J. and Stagg, C. J. and Fleming and others},
  title   = {{Perceptions of non-invasive brain stimulation and barriers to it's clinical translation: a multi-stakeholder focus group study}},
  journal = {medRxiv (preprint)},
  year    = {2026},
  doi     = {10.64898/2026.08.24.26361180},
  url     = {https://doi.org/10.64898/2026.08.24.26361180}
}

@article{wu2026-b062eef4,
  author  = {Wu, R. and Pugh, S. and OCOnnor, K. B. and Xie, K. and O'Brien, K. and Johnson, K.},
  title   = {{Detecting Self-Repairs from Spontaneous Speech with Prompt Ablation Across LLMs and Fine-Tuned Encoder}},
  journal = {medRxiv (preprint)},
  year    = {2026},
  doi     = {10.64898/2026.08.21.26360471},
  url     = {https://doi.org/10.64898/2026.08.21.26360471}
}

@article{han2026-6bbe6bcc,
  author  = {Han, S. and Hewett, J. and Ahmadizar, F. and Biessels, G. J.},
  title   = {{Metabolomic signatures of data-driven type 2 diabetes subtypes and their associations with dementia and stroke risk}},
  journal = {medRxiv (preprint)},
  year    = {2026},
  doi     = {10.64898/2026.08.21.26361082},
  url     = {https://doi.org/10.64898/2026.08.21.26361082}
}

@article{turcan2026-c0254966,
  author  = {Turcan, A. and Hou, K. and Lin, K. Z. and Pfenning, A. and Sakaue, S. and Zhang, M. J.},
  title   = {{Conditional polygenic enrichment distinguishes causal from tagging disease-critical cell populations in single-cell RNA-seq}},
  journal = {medRxiv (preprint)},
  year    = {2026},
  doi     = {10.64898/2026.08.20.26360914},
  url     = {https://doi.org/10.64898/2026.08.20.26360914}
}

@article{kacar2026-3f99fee9,
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  title   = {{Genome-wide analyses reveal shared and distinct genetic architecture linking amyotrophic lateral sclerosis, sporadic frontotemporal dementia and cognitive traits}},
  journal = {medRxiv (preprint)},
  year    = {2026},
  doi     = {10.64898/2026.08.17.26360494},
  url     = {https://doi.org/10.64898/2026.08.17.26360494}
}

@article{jensen2026-322d13ed,
  author  = {Jensen, T. D. and Le Guen, Y. and Talozzi, L. and Yang, S. and Gorzynski, J. and Pena-Tauber, A. and Stewart, I. and Ferrasse and others},
  title   = {{Long-read genome sequencing and multi-omics in aging and neurodegeneration}},
  journal = {medRxiv (preprint)},
  year    = {2026},
  doi     = {10.1101/2025.10.10.25337775},
  url     = {https://doi.org/10.1101/2025.10.10.25337775}
}

@article{skjaerbaek2026-ad526bca,
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  title   = {{Self-applied single-channel mastoid ExG for fully automated detection of REM sleep behaviour disorder}},
  journal = {medRxiv (preprint)},
  year    = {2026},
  doi     = {10.64898/2026.08.14.26360475},
  url     = {https://doi.org/10.64898/2026.08.14.26360475}
}

@article{kuruvilla2026-cd8b8955,
  author  = {Kuruvilla, J. M. and Rifai, O. M. and Longden, J. and Gregory, J. M. and Vallejo, M.},
  title   = {{Exploring Machine Learning Models to Uncover Pathways in ALS Pathogenesis Using Immunohistochemical Features}},
  journal = {medRxiv (preprint)},
  year    = {2026},
  doi     = {10.64898/2025.12.19.25342356},
  url     = {https://doi.org/10.64898/2025.12.19.25342356}
}

@article{ignatavicius2026-d2399b77,
  author  = {Ignatavicius, A. and Konuri, A. and Churchill, L. and Anderson, J. and Halliday, G. M. and Lewis, S. J. and Matar, E.},
  title   = {{Impaired cerebrovascular-cerebrospinal fluid coupling is associated with non-motor features of Lewy body disease}},
  journal = {medRxiv (preprint)},
  year    = {2026},
  doi     = {10.64898/2026.05.13.26353090},
  url     = {https://doi.org/10.64898/2026.05.13.26353090}
}

@article{shin2026-a566b431,
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  title   = {{GCH1 genetic variation as a prognostic factor in Parkinsons disease across populations}},
  journal = {medRxiv (preprint)},
  year    = {2026},
  doi     = {10.64898/2026.08.14.26359677},
  url     = {https://doi.org/10.64898/2026.08.14.26359677}
}

@article{salazar2026-28f7dc41,
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  title   = {{Fine-mapping reveals four TMEM106B haplotypes associated with neurodegenerative risk and preserved cognition at extreme age}},
  journal = {medRxiv (preprint)},
  year    = {2026},
  doi     = {10.1101/2025.02.02.25321330},
  url     = {https://doi.org/10.1101/2025.02.02.25321330}
}

@article{taylor2026-9c23dcf2,
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  title   = {{A Phase 2b randomized clinical trial of the oral p38α inhibitor neflamapimod in dementia with Lewy bodies (DLB)}},
  journal = {Research Square},
  year    = {2026},
  doi     = {10.21203/rs.3.rs-10623740/v1},
  url     = {https://doi.org/10.21203/rs.3.rs-10623740/v1}
}

@article{legrand2026-1c507e85,
  author  = {Le Grand, Q. and Koch, A. and Imtiaz, M.-A. and Maier, G. and Talevi, V. and Liu, D. and Aziz, N. A. and Breteler and others},
  title   = {{Diffusion kurtosis imaging (gen)omics unravels mechanisms of cerebral small vessel disease}},
  journal = {medRxiv (preprint)},
  year    = {2026},
  doi     = {10.64898/2026.08.12.26360241},
  url     = {https://doi.org/10.64898/2026.08.12.26360241}
}

@article{lehmann2026-77405502,
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  title   = {{Population-based reference equations and Z-scores for blood biomarkers of neurodegenerative diseases}},
  journal = {medRxiv},
  year    = {2026},
  doi     = {10.64898/2026.08.09.26360027},
  url     = {https://doi.org/10.64898/2026.08.09.26360027}
}

@article{gunasekaran2026-cddcbabb,
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  title   = {{Antemortem α-Synuclein levels from neuron-derived extracellular vesicles identify Lewy Body pathology in Parkinson’s Disease and Alzheimer Disease}},
  journal = {medRxiv},
  year    = {2026},
  doi     = {10.64898/2026.08.03.26359636},
  url     = {https://doi.org/10.64898/2026.08.03.26359636}
}

@article{nuanyi2026-41674595,
  author  = {Nuanyi, Liang and Siamak, Mahmoudiandehkordi and Heston Margo, B. and Pallavi, Kaushik and Ryan, Powell W and Naama, Karu and Dempsey Desarae, A. and Labus Jennifer, S. and others},
  title   = {{The Metabolome as a Readout for Adverse Social Exposome Influences on Human Health - A Roadmap for Modifiable Factors and Proactive Health}},
  journal = {medRxiv : the preprint server for health sciences},
  year    = {2026},
  doi     = {10.64898/2026.02.02.26344798},
  pmid    = {41674595},
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}

@article{khaliq2025-40633409,
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  title   = {{RETRACTED: Revolutionizing medical imaging: A cutting-edge AI framework with vision transformers and perceiver IO for multi-disease diagnosis}},
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  year    = {2025},
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  pmid    = {40633409},
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@article{zammit2025-8ec63439,
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  title   = {{A head-to-head comparison of multiple amyloid PET radiotracers for Down syndrome clinical trials}},
  journal = {medRxiv},
  year    = {2025},
  doi     = {10.1101/2025.03.18.25324200},
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@article{sciences2024-e69e4b94,
  author  = {Sciences, Cassava},
  title   = {{Cassava Sciences Topline Phase 3 Data Did Not Meet Co-Primary Endpoints (ReThink-ALZ)}},
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}

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  author  = {Lesné, S. and Koh, M. T. and Kotilinek, L. and Kayed, R. and Glabe, C. G. and Yang, A. and Gallagher, M. and Ashe, K. H.},
  title   = {{Retraction Note: A specific amyloid-beta protein assembly in the brain impairs memory}},
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  title   = {{A disease similarity approach identifies short-lived Niemann-Pick type C disease mice with accelerated brain aging as a novel mouse model for Alzheimer’s disease and aging research}},
  journal = {bioRxiv},
  year    = {2024},
  doi     = {10.1101/2024.04.19.590328},
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  journal = {bioRxiv},
  year    = {2024},
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