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sleep
196 studies tagged sleep, dated 1983 to 2026-10-16. Bibliography: BibTeX (.bib) · RIS (.ris)
Newest in this topic
- Progressive neurodegeneration of the locus coeruleus drives rapid eye movement sleep fragmentation 2026-10-16
- REM sleep EEG slowing signals basal forebrain integrity in older adults with subjective and mild cognitive impairment 2026-10-02
- A systems-level model of sleep-dependent memory-consolidation failure in neurodegeneration: the spindle–slow-oscillation decoupling cascade dissociates amyloid and tau 2026-09-29
Studies
196 studies carry this tag.
Date range
1983 to 2026
Top journals
- Alzheimer's & dementia : the journal of the Alzheimer's Association 12
- bioRxiv 7
- medRxiv 7
- Journal of Alzheimer's disease : JAD 6
- Sleep 5
128 journals in all.
Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.
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16/100
Sleep disturbances are common early features of neurodegenerative disorders such as Alzheimer’s disease (AD) and Parkinson’s disease (PD).
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The basal forebrain is an early site of pathology in Alzheimer’s disease (AD).
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We built a computer model that reproduces the rhythms and, crucially, lets the measured timing between slow waves and spindles control how strongly memories are written into cortex.
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In the English Longitudinal Study of Ageing (ELSA: n=9,473, median age 64, range 50 to ≥90), linear mixed-effects models examined age-specific differences in cognitive change (recall and fluency) associated with sleep duration, difficulty falling asleep, nocturnal awakenings, incorporating sleep-by-age-by-time interactions, with initial adjustment for sociodemographic factors and further adjustment for health and lifestyle factors.
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16/100
Sleep disturbances are pervasive in Lewy body disorders (LBD), but their neurophysiological basis remains unclear.
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Insomnia disorder affects approximately 10–20% of adults and is usually chronic.
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16/100
Amyloid-beta (Aβ) accumulation in the brain is linked to Alzheimer’s disease.
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Participants were aged 60–94 years, with a mean age of 78.5 ± 7.9 years, and 45.7% were women.
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The short-wavelength content of available light declines steadily through the afternoon, well before nightfall, while the long-wavelength component remains nearly constant.
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16/100
Circadian disruption, notably sleep disturbances, serves as an early indicator of Alzheimer’s disease (AD), preceding cognitive symptoms like memory loss.
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Sleep disturbance in Alzheimer’s disease (AD), particularly the reduction of slow wave sleep (SWS), has been proposed as a novel therapeutic target, with disease-modifying potential.
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Controlling for baseline differences, treatment of OSA improved delayed recall and may reduce the slope of memory decline in Alzheimer’s disease and vascular dementia.
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50/100
Sleep apnea is associated with an increased risk of Parkinson disease.
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Sleeping more than one’s usual average the night before testing was associated with better delayed memory ( β = 0.03, p = 0.02), while no between-person sleep effects emerged.
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Traumatic brain injuries (TBIs) are associated with increased risk of neurodegenerative disease, including Alzheimer’s disease (AD); however, the mechanisms by which TBI promotes AD pathogenesis remain poorly understood.
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16/100
Sleep disruption is common in Alzheimer’s disease (AD).
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Agitation days showed higher median sample entropy (1.23 vs 1.06; p<0.001) and approximate entropy (1.24 vs 1.08; p<5 × 10−19).
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Sleep duration exhibited a U-shaped association with SPARE-AD (p = 0.001), Trail Making Tests A and B, and the Digit Symbol Substitution Test (all p < 0.001).
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Baseline sleep disturbance was associated with a faster rate of longitudinal CSF Aβ42 decline.
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After multivariable adjustment, longer sleep duration was associated with lower Aβ42/40, poor sleep quality with higher NfL, daytime sleepiness with both lower Aβ42/40 and higher NfL, and insomnia symptoms with higher SPARE-AD.
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Passive sleep monitoring identified physiologically interpretable sleep markers associated with next-day agitation occurrence, supporting prospective evaluation of under-mattress sensing as a source of short-term risk information for dementia care.
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In cognitively unimpaired older adults, associations between sleep disturbances and psycho-affective symptoms differ according to Aβ status.
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Shorter sleep duration and greater REM sleep variability may index early AD-related brain changes, warranting longitudinal studies to establish their prognostic significance.
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The MCI group had the most surprising findings—although they were cognitively similar to the control group, they were less physically active than the AD group and had the worst sleep efficiency.
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The study included 44 iRBD patients (81.8% males, mean age 71.0 ± 6.4 years), 55 HC (66.3% males, mean age 69.1 ± 5.5 years), and 28 AD patients (82.1% males, mean age of 70.4 ± 6.7 years). iRBD patients showed significantly higher plasma NfL and GFAP levels and similar pTau181 levels compared to HC.
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Over 3.7 years, 22 patients phenoconverted (7 multiple system atrophy [MSA]; 15 Lewy body diseases [LBDs]).
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Fifty-nine primary studies met all criteria.
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AD was characterized by longer time in bed, more bed exits, less snoring, and changes in estimated sleep states.
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Obstructive sleep apnea is one of the most common sleep disorders.
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About 30% to 40% of the general population experiences insomnia symptoms of difficulty initiating or maintaining sleep, and another 10% to 15% of the general population experiences chronic insomnia disorder.
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Sleep disorders, particularly insomnia and obstructive sleep apnea, are increasingly implicated as significant contributors to cognitive decline, dementia, and neurodegenerative diseases such as Alzheimer's disease (AD) and vascular cognitive impairment and dementia (VCID).
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In total, 30 studies were included comprising 14,997 subjects.
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Insomnia has now become a major health problem of global concern, with about 1/3 of the population suffering from sleep problems, a proportion that is still rising year by year.
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Studies suggest that individuals who experience memory loss may encounter sleep disturbances before noticing other symptoms.
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Alzheimer's disease (AD) is the most prevalent dementia, pathologically featuring abnormal accumulation of amyloid-β (Aβ) and hyperphosphorylated tau, while sleep, divided into rapid eye movement sleep (REM) and nonrapid eye movement sleep (NREM), plays a key role in consolidating social and spatial memory.
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59/100
Baseline pRBD was associated with faster decline in global cognition and all cognitive domains, including verbal episodic memory, visuospatial ability, executive function, language, and processing speed.
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54/100
In participants with impaired cognition, baseline sleep apnea was related to better baseline MoCA performance (b = 0.65, 95% confidence interval [95% CI] = [0.07, 1.23]) and less decline in GCA over time (b = 0.06, 95% CI = [0.001, 0.12]).
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Sleep apnea is regarded as an important risk factor in the pathogenesis of Alzheimer disease (AD).
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Lower cerebrospinal fluid (CSF) ApoE, higher CSF p-tau181/amyloid-β (Aβ)42, and higher plasma p-tau231/Aβ42 were associated with higher variability of sleep midpoint, sleep duration, and/or activity count.
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In IPTW, we observed a decreased risk of terminated healthspan for healthy sleep behaviors such as 'sleep duration 7-8h/d' (Hazard ratio, HR = 0.93; 95 % confidence interval, CI: 0.92-0.96; P < 0.001); 'morningness' (HR = 0.95; 95%CI: 0.93-0.98; P < 0.01); 'napping' (HR = 0.93; 95%CI: 0.91-0.94; P < 0.001); 'easy getting up from bed' (HR = 0.91; 95%CI: 0.88-0.93; P < 0.001); and, 'never/rarely experience sleeplessness/insomnia' (HR = 0.94; 95%CI: 0.92-0.96; P < 0.001).
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Accumulating evidence supports a link between sleep disorders, disturbed sleep, and adverse brain health, ranging from stroke to subclinical cerebrovascular disease to cognitive outcomes, including the development of Alzheimer disease and Alzheimer disease-related dementias.
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Compared to controls, bvFTD patients showed longer time in bed (95% confidence interval [CI]: 79.31, 321.83) and total sleep time (95% CI: 24.38, 321.88), lower sleep efficiency (95% CI: -12.58, -95.54), and rest-activity rhythm alterations in the morning and early afternoon.
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The important functions of sleep include cleaning processes such as the elimination of metabolic products, e.g., amyloid, via the glymphatic system; consolidation of memory; and anabolic regulation of metabolism.
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Poor sleep efficiency and sleep fragmentation are linked with poorer executive function and increased risk of dementia during follow-up.
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The final analytic sample included n = 2334 participants.
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Sleep is essential for human well-being, yet the quality and quantity of sleep reduce as age advances.
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41/100
Aging is associated with changes in sleep structure and cerebral deposition of amyloid beta and tau proteins.
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A growing number of studies, in animal models and humans, have highlighted the link between sleep and Alzheimer's disease (AD) pathophysiology.
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Sample sizes for individuals with comorbid insomnia ranged from 23,168 (T2DM) to 3,015 (ADRDs).
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In the whole sample, a higher apnea-hypopnea index was significantly associated with lower FC between (i) the medial prefrontal cortex and bilateral hippocampi, and (ii) the left hippocampus and both the posterior cingulate cortex and precuneus.
From across this tag
8 of the 196 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 8. The same 8 appear here every time.
- Sleep-related behaviors in Alzheimer’s disease and dementia with Lewy bodies
- Polysomnographic assessment of suvorexant in patients with probable Alzheimer's disease dementia and insomnia: a randomized trial
- A multicenter, placebo-controlled trial of melatonin for sleep disturbance in Alzheimer's disease
- Insomnia in Older Adults
- Sharper in the morning: Cognitive time of day effects revealed with high-frequency smartphone testing
- Sleep apnoea and cognitive impairment: myth or reality?
- Sleep, Pain, and Neurodegeneration: A Mendelian Randomization Study
- Longitudinal associations between sleep duration and cognitive impairment in Chinese elderly