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Home › Research › Topic

Inflammation, microglia and astrocytes

730 studies in this group. A computer grouped them by what their titles and summaries are about, not by a hand-made list. The name describes most of the group, not every study in it.

Each study has a usefulness score out of 100 (rubric version 4.0). Tap a score to see what makes it up.

Highest usefulness score first. Studies without a score come last.

  1. Microglia TFEB activation attenuates Alzheimer's disease pathology by enhancing autophagy-lysosomal function

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Journal of neuroinflammation 2026-02-11 Inflammation and the immune system

    Alzheimer's disease (AD) is characterized by amyloid-β (Aβ) accumulation, neuroinflammation, synaptic dysfunction, and cognitive decline.

  2. Glymphatic transport and ocular diseases

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Progress in retinal and eye research 2025-12-23 Brain scans and imaging

    The high metabolic demand of retinal neurons requires tightly regulated mechanisms to maintain homeostasis and ensure the efficient clearance of metabolic waste and excess water.

  3. The Alzheimer's disease risk genes MS4A4A and MS4A6A cooperate to negatively regulate TREM2 and microglia states

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Neuron 2025-12-22 TREM2 and immune genetics

    Genetic variations in MS4A4A and MS4A6A Triggering receptor expressed on myeloid cells 2 (TREM2) are linked to the regulation of cerebrospinal-fluid-soluble TREM2 levels and are associated with Alzheimer's disease (AD) risk and progression.

  4. Role of TREM2 in neuroinflammation

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Experimental neurology 2025-11-08 TREM2 and immune genetics

    Triggering receptor expressed on myeloid cells 2 (TREM2) is cell surface transmembrane receptor of the TREM family, predominantly expressed on microglia within the central nervous system (CNS).

  5. Mouse models of Anti-Aβ immunotherapies

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Molecular neurodegeneration 2025-05-13 Treatments

    This review considers the use of these mouse models in understanding the mechanisms of Aβ clearance, cerebral amyloid angiopathy (CAA), blood brain barrier breakdown, neuroinflammation, and neuronal dysfunction in response to Aβ immunotherapy.

  6. The role of neuroinflammation in cerebral amyloid angiopathy

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. EBioMedicine 2024-11-29 Treatments

    Cerebral amyloid angiopathy (CAA) is a cerebrovascular disease characterized by vascular amyloid-β (Aβ) deposition.

  7. Amyloid-β (Aβ) immunotherapy induced microhemorrhages are linked to vascular inflammation and cerebrovascular damage in a mouse model of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Molecular neurodegeneration 2024-10-21 Treatments

    Our study has established a significant link between CAA-Aβ antibody immune complex formation, immune activation and vascular damage leading to smooth muscle cell loss.

  8. Three major effects of APOE ε4 on Aβ immunotherapy induced ARIA

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Frontiers in aging neuroscience 2024-05-02 Treatments

    The targeting of amyloid-beta (Aβ) plaques therapeutically as one of the primary causes of Alzheimer's disease (AD) dementia has been an ongoing effort spanning decades.

  9. INPP5D regulates inflammasome activation in human microglia

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Nature communications 2023-11-29 Inflammation and the immune system

    Microglia and neuroinflammation play an important role in the development and progression of Alzheimer's disease (AD).

  10. Targeting NLRP3 inflammasome for neurodegenerative disorders

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Molecular psychiatry 2023-09-05 Inflammation and the immune system

    Neuroinflammation is a key pathological feature in neurological diseases, including Alzheimer's disease (AD).

  11. Single-cell analysis reveals inflammatory interactions driving macular degeneration

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Nature communications 2023-05-05 Genetics

    Due to commonalities in pathophysiology, age-related macular degeneration (AMD) represents a uniquely accessible model to investigate therapies for neurodegenerative diseases, leading us to examine whether pathways of disease progression are shared across neurodegenerative conditions.

  12. APOE and immunity: Research highlights

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2023-03-28 TREM2 and immune genetics

    During the 4-day meeting, presenters illuminated aspects of the cross-talk between APOE and immunity, with a focus on the roles of microglia, triggering receptor expressed on myeloid cells 2 (TREM2), and components of inflammation (e.g., tumor necrosis factor α [TNFα]).

  13. Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Nature 2023-03-08 Brain scans and imaging

    Extracellular deposition of amyloid-β as neuritic plaques and intracellular accumulation of hyperphosphorylated, aggregated tau as neurofibrillary tangles are two of the characteristic hallmarks of Alzheimer's disease 1,2 .

  14. TOMM40 Genetic Variants Cause Neuroinflammation in Alzheimer's Disease

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. International journal of molecular sciences 2023-02-17 Inflammation and the immune system

    Translocase of outer mitochondrial membrane 40 (TOMM40) is located in the outer membrane of mitochondria.

  15. Pyroptosis in Alzheimer's disease: cell type-specific activation in microglia, astrocytes and neurons

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Acta neuropathologica 2022-12-09 Inflammation and the immune system

    The major neuropathological hallmarks of Alzheimer's disease (AD) are amyloid β (Aβ) plaques and neurofibrillary tangles (NFT), accompanied by neuroinflammation and neuronal loss.

  16. Parenchymal border macrophages regulate the flow dynamics of the cerebrospinal fluid

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Nature 2022-11-09 Genetics

    Macrophages are important players in the maintenance of tissue homeostasis 1 .

  17. Exercise plasma boosts memory and dampens brain inflammation via clusterin

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Nature 2021-12-08 Genetics

    Physical exercise is generally beneficial to all aspects of human and animal health, slowing cognitive ageing and neurodegeneration 1 .

  18. Acute systemic inflammation exacerbates neuroinflammation in Alzheimer's disease: IL-1β drives amplified responses in primed astrocytes and neuronal network dysfunction

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Alzheimer's & dementia : the journal of the Alzheimer's Association 2021-06-03 Inflammation and the immune system

    Neuroinflammation contributes to Alzheimer's disease (AD) progression.

  19. Gamma subunit of complement component 8 is a neuroinflammation inhibitor

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Brain : a journal of neurology 2021-03-03 Inflammation and the immune system

    The complement system is part of the innate immune system that comprises several small proteins activated by sequential cleavages.

  20. The influence of the R47H triggering receptor expressed on myeloid cells 2 variant on microglial exosome profiles

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Brain communications 2021-02-03 TREM2 and immune genetics

    Variants in the triggering receptor expressed on myeloid cells 2 gene are linked with an increased risk of dementia, in particular the R47Hhet triggering receptor expressed on myeloid cells 2 variant is linked to late-onset Alzheimer's disease.

  21. Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Nature communications 2020-11-30 Genetics

    The extent of microglial heterogeneity in humans remains a central yet poorly explored question in light of the development of therapies targeting this cell type.

  22. CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Brain : a journal of neurology 2019-10-01 Genetics

    Neuroinflammation and microglial activation are significant processes in Alzheimer's disease pathology.

  23. Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer's disease model

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Nature communications 2019-08-21 Inflammation and the immune system

    Many risk genes for the development of Alzheimer's disease (AD) are exclusively or highly expressed in myeloid cells.

  24. A transcriptomic atlas of aged human microglia

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Nature communications 2018-02-07 Genetics

    With a rapidly aging global human population, finding a cure for late onset neurodegenerative diseases has become an urgent enterprise.

  25. Functional morphology of the blood-brain barrier in health and disease

    ✓ Peer-reviewed alzhub usefulness score 45 out of 100. Acta neuropathologica 2018-02-06 Inflammation and the immune system

    The adult quiescent blood-brain barrier (BBB), a structure organised by endothelial cells through interactions with pericytes, astrocytes, neurons and microglia in the neurovascular unit, is highly regulated but fragile at the same time.

From across this topic

10 of the 730 studies in this topic, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

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