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Home › Research › Topics › mice

mice

1,163 studies tagged mice, dated 1986-01-01 to 2026-09-25. Bibliography: BibTeX (.bib) · RIS (.ris)

Newest in this topic

  1. What Do Sugar, Gila Monsters, and the Therapeutic Dance Have in Common With GLP-1RA, Stroke, and Dementia? 2026-09-25
  2. Myo-inositol as a spectroscopic marker of neuroinflammation in frontotemporal lobar degeneration 2026-09-20
  3. Laromestrocel preserves brain volume and cognitive function in Alzheimers disease by inhibiting neuroinflammation 2026-09-17

Studies

1,163 studies carry this tag.

Date range

1986 to 2026

Top journals

  • The Journal of biological chemistry 109
  • The Journal of neuroscience : the official journal of the Society for Neuroscience 42
  • Proceedings of the National Academy of Sciences of the United States of America 39
  • Neuron 28
  • Nature 23

365 journals in all.

Newest first, then by address. Each study has a usefulness score out of 100 (rubric version 4.0); tap a score to see what makes it up. Tags were assigned automatically from each study's title and summary. The same studies as a filter in the library.

  1. Apolipoprotein E4 impairs the response of neurodegenerative retinal microglia and prevents neuronal loss in glaucoma

    ✓ Peer-reviewed alzhub usefulness score 54 out of 100. Immunity 2022-08-16 Genetics

    The apolipoprotein E4 (APOE4) allele is associated with an increased risk of Alzheimer disease and a decreased risk of glaucoma, but the underlying mechanisms remain poorly understood.

  2. Galectin-3, a rising star in modulating microglia activation under conditions of neurodegeneration

    ✓ Peer-reviewed alzhub usefulness score 49 out of 100. Cell death & disease 2022-07-20 TREM2 and immune genetics

    The advent of high-throughput single-cell transcriptomic analysis of microglia has revealed different phenotypes that are inherently associated with disease conditions.

  3. Insulin and insulin-like growth factor-I receptors in astrocytes exert different effects on behavior and Alzheimer´s-like pathology

    ✓ Peer-reviewed alzhub usefulness score 34 out of 100. F1000Research 2022-06-16 Biomarkers

    We observed that mice lacking IR in GFAP astrocytes (GFAP IR KO mice) develop mood disturbances and maintained intact cognition, while at the same time show greater pathology when cross-bred with APP/PS1 mice, a model of familial Alzheimer´s disease (AD).

  4. Long term high fat diet induces metabolic disorders and aggravates behavioral disorders and cognitive deficits in MAPT P301L transgenic mice

    ✓ Peer-reviewed alzhub usefulness score 38 out of 100. Metabolic brain disease 2022-06-15 Tau biomarkers

    Most Alzheimer disease (AD) patients present as sporadic late onset AD, with metabolic factors playing an important role in the occurrence and development of AD.

  5. Lipid-associated macrophages in the tumor-adipose microenvironment facilitate breast cancer progression

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Oncoimmunology 2022-06-08 TREM2 and immune genetics

    The tumor-adipose microenvironment (TAME) is a universal microecosystem, that is characterized by the dysfunction of lipid metabolism, such as excessive free fatty acids (FFAs).

  6. Cyanidin-3-O-Glucoside Regulates the M1/M2 Polarization of Microglia via PPARγ and Aβ42 Phagocytosis Through TREM2 in an Alzheimer's Disease Model

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. Molecular neurobiology 2022-06-07 TREM2 and immune genetics

    Microglial polarization plays an essential role in the progression and regression of neurodegenerative disorders.

  7. Reversal of synapse loss in Alzheimer mouse models by targeting mGluR5 to prevent synaptic tagging by C1Q

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Science translational medicine 2022-06-01 Disease mechanisms

    Microglia-mediated synaptic loss contributes to the development of cognitive impairments in Alzheimer's disease (AD).

  8. Myeloid LXR (Liver X Receptor) Deficiency Induces Inflammatory Gene Expression in Foamy Macrophages and Accelerates Atherosclerosis

    ✓ Peer-reviewed alzhub usefulness score 48 out of 100. Arteriosclerosis, thrombosis, and vascular biology 2022-04-28 TREM2 and immune genetics

    Cholesterol loaded macrophage foam cells are a prominent feature of atherosclerotic plaques.

  9. Loss of perivascular aquaporin-4 localization impairs glymphatic exchange and promotes amyloid β plaque formation in mice

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Alzheimer's research & therapy 2022-04-26 Caregiving

    These findings suggest that the loss of perivascular AQP4 localization may contribute to the development of AD pathology in human populations.

  10. Hypoxic pretreatment of adipose-derived stem cell exosomes improved cognition by delivery of circ-Epc1 and shifting microglial M1/M2 polarization in an Alzheimer's disease mice model

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Aging 2022-04-01 TREM2 and immune genetics

    Alzheimer's disease (AD) is the most common dementia in the world.

  11. Retraction: High-Affinity Naloxone Binding to Filamin A Prevents Mu Opioid Receptor-Gs Coupling / Retraction: Naloxone's Pentapeptide Binding Site on Filamin A Blocks Mu Opioid Receptor-Gs Coupling (among five Wang-authored papers retracted)

    ⚠ Retracted — do not rely on it alzhub usefulness score 12 out of 100. PLOS ONE 2022-03-30 Laboratory science

    Following an anonymous 2021 whistleblower petition to the FDA alleging manipulated research underlying the Alzheimer's drug simufilam, PLOS ONE conducted its own investigation and retracted five papers co-authored by Hoau-Yan Wang, some of them co-authored with a Cassava Sciences executive, after finding that background patterns in blot images appeared 'more similar than would be expected for data obtained in independent experiments.'

  12. TDP-43 loss and ALS-risk SNPs drive mis-splicing and depletion of UNC13A

    ✓ Peer-reviewed alzhub usefulness score 64 out of 100. Nature 2022-02-23 Lewy body dementia

    Variants of UNC13A, a critical gene for synapse function, increase the risk of amyotrophic lateral sclerosis and frontotemporal dementia 1-3 , two related neurodegenerative diseases defined by mislocalization of the RNA-binding protein TDP-43 4,5 .

  13. TDP-43 represses cryptic exon inclusion in the FTD-ALS gene UNC13A

    ✓ Peer-reviewed alzhub usefulness score 64 out of 100. Nature 2022-02-23 Lewy body dementia

    A hallmark pathological feature of the neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is the depletion of RNA-binding protein TDP-43 from the nucleus of neurons in the brain and spinal cord 1 .

  14. Astrocytic α2-Na+/K+ ATPase inhibition suppresses astrocyte reactivity and reduces neurodegeneration in a tauopathy mouse model

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Science translational medicine 2022-02-16 Disease mechanisms

    Alzheimer's disease (AD) is the most dominant form of dementia characterized by the deposition of extracellular amyloid plaques and intracellular neurofibrillary tau tangles (NFTs).

  15. Endoplasmic reticulum-mitochondria signaling in neurons and neurodegenerative diseases

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Journal of cell science 2022-02-07 Disease mechanisms

    Recent advances have revealed common pathological changes in neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis with related frontotemporal dementia (ALS/FTD).

  16. Disease-linked TDP-43 hyperphosphorylation suppresses TDP-43 condensation and aggregation

    ✓ Peer-reviewed alzhub usefulness score 52 out of 100. The EMBO journal 2022-02-03 Brain tissue and pathology

    Post-translational modifications (PTMs) have emerged as key modulators of protein phase separation and have been linked to protein aggregation in neurodegenerative disorders.

  17. Glucosylceramide synthase inhibition reduces ganglioside GM3 accumulation, alleviates amyloid neuropathology, and stabilizes remote contextual memory in a mouse model of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Alzheimer's research & therapy 2022-02-01 Prevention trials

    Our results indicate that glycosphingolipids regulated by GCS are important modulators of Aβ neuropathology and that glycosphingolipid homeostasis plays a critical role in the consolidation of remote memories.

  18. Rehmannioside A improves cognitive impairment and alleviates ferroptosis via activating PI3K/AKT/Nrf2 and SLC7A11/GPX4 signaling pathway after ischemia

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Journal of ethnopharmacology 2022-01-26 Vascular contributions

    Materials and methods Differentially expressed proteins (DEPs) in patients after cerebral ischemic stroke were revealed by a RayBio protein array.

  19. Antisense oligonucleotide silencing of FUS expression as a therapeutic approach in amyotrophic lateral sclerosis

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Nature medicine 2022-01-24 Caregiving

    Fused in sarcoma (FUS) is an RNA-binding protein that is genetically and pathologically associated with rare and aggressive forms of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).

  20. A Perspective on Nrf2 Signaling Pathway for Neuroinflammation: A Potential Therapeutic Target in Alzheimer's and Parkinson's Diseases

    ✓ Peer-reviewed alzhub usefulness score 49 out of 100. Frontiers in cellular neuroscience 2022-01-21 Inflammation and the immune system

    Neuroinflammation plays a pivotal role in Alzheimer's disease (AD) and Parkinson's disease (PD), the leading causes of dementia.

  21. Progranulin as a therapeutic target in neurodegenerative diseases

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Trends in pharmacological sciences 2022-01-15 Inflammation and the immune system

    Progranulin (PGRN, encoded by the GRN gene) plays a key role in the development, survival, function, and maintenance of neurons and microglia in the mammalian brain.

  22. Elevated microglial oxidative phosphorylation and phagocytosis stimulate post-stroke brain remodeling and cognitive function recovery in mice

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. Communications biology 2022-01-11 TREM2 and immune genetics

    New research shows that disease-associated microglia in neurodegenerative brains present features of elevated phagocytosis, lysosomal functions, and lipid metabolism, which benefit brain repair.

  23. Soluble TAM receptors sAXL and sTyro3 predict structural and functional protection in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 59 out of 100. Neuron 2022-01-06 Tau biomarkers

    There is an urgent need to improve the understanding of neuroinflammation in Alzheimer's disease (AD).

  24. Human neural cell type-specific extracellular vesicle proteome defines disease-related molecules associated with activated astrocytes in Alzheimer's disease brain

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Journal of extracellular vesicles 2022-01-01 Mild cognitive impairment

    In neurodegenerative diseases, extracellular vesicles (EVs) transfer pathogenic molecules and are consequently involved in disease progression.

  25. APOE2, E3, and E4 differentially modulate cellular homeostasis, cholesterol metabolism, and inflammatory response in isogenic iPSC-derived astrocytes

    ✓ Peer-reviewed alzhub usefulness score 33 out of 100. Stem cell reports 2021-12-16 Genetics

    The apolipoprotein E4 (APOE4) variant is the strongest genetic risk factor for Alzheimer disease (AD), while the APOE2 allele is protective.

  26. Plasma neurofilament light chain protein is not increased in treatment-resistant schizophrenia and first-degree relatives

    ✓ Peer-reviewed alzhub usefulness score 49 out of 100. The Australian and New Zealand journal of psychiatry 2021-11-17 Biomarkers

    Treatment-resistant schizophrenia does not appear to be associated with neuronal, particularly axonal degeneration.

  27. Novel Galectin-3 Roles in Neurogenesis, Inflammation and Neurological Diseases

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Cells 2021-11-05 TREM2 and immune genetics

    Galectin-3 (Gal-3) is an evolutionarily conserved and multifunctional protein that drives inflammation in disease.

  28. MEF2 is a key regulator of cognitive potential and confers resilience to neurodegeneration

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Science translational medicine 2021-11-03 Disease mechanisms

    Recent increases in human longevity have been accompanied by a rise in the incidence of dementia, highlighting the need to preserve cognitive function in an aging population.

  29. Microglial activation states drive glucose uptake and FDG-PET alterations in neurodegenerative diseases

    ✓ Peer-reviewed alzhub usefulness score 57 out of 100. Science translational medicine 2021-10-13 TREM2 and immune genetics

    2-Deoxy-2-[ 18 F]fluoro-d-glucose positron emission tomography (FDG-PET) is widely used to study cerebral glucose metabolism.

  30. Whole-exome sequencing reveals a role of HTRA1 and EGFL8 in brain white matter hyperintensities

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. Brain : a journal of neurology 2021-10-01 Long-term cohort studies

    White matter hyperintensities (WMH) are among the most common radiological abnormalities in the ageing population and an established risk factor for stroke and dementia.

  31. METTL3-dependent RNA m6A dysregulation contributes to neurodegeneration in Alzheimer's disease through aberrant cell cycle events

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Molecular neurodegeneration 2021-09-30 Disease mechanisms

    These data suggested that METTL3 reduction-mediated m 6 A dysregulation likely contributes to neurodegeneration in AD which may be a therapeutic target for AD.

  32. NAD+ improves cognitive function and reduces neuroinflammation by ameliorating mitochondrial damage and decreasing ROS production in chronic cerebral hypoperfusion models through Sirt1/PGC-1α pathway

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. Journal of neuroinflammation 2021-09-16 Inflammation and the immune system

    Microglial-mediated neuroinflammation plays an important role in vascular dementia, and modulating neuroinflammation has emerged as a promising treatment target.

  33. Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic

    ✓ Peer-reviewed alzhub usefulness score 53 out of 100. Cell 2021-08-26 Inflammation and the immune system

    GRN mutations cause frontotemporal dementia (GRN-FTD) due to deficiency in progranulin (PGRN), a lysosomal and secreted protein with unclear function.

  34. Biomarkers of conversion to α-synucleinopathy in isolated rapid-eye-movement sleep behaviour disorder

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. The Lancet. Neurology 2021-08-01 Risk factors

    Patients with isolated rapid-eye-movement sleep behaviour disorder (RBD) are commonly regarded as being in the early stages of a progressive neurodegenerative disease involving α-synuclein pathology, such as Parkinson's disease, dementia with Lewy bodies, or multiple system atrophy.

  35. Microglial-glucocorticoid receptor depletion alters the response of hippocampal microglia and neurons in a chronic unpredictable mild stress paradigm in female mice

    ✓ Peer-reviewed alzhub usefulness score 46 out of 100. Brain, behavior, and immunity 2021-07-31 TREM2 and immune genetics

    Chronic psychological stress is one of the most important triggers and environmental risk factors for neuropsychiatric disorders.

  36. Lysosomal TPCN (two pore segment channel) inhibition ameliorates beta-amyloid pathology and mitigates memory impairment in Alzheimer disease

    ✓ Peer-reviewed alzhub usefulness score 43 out of 100. Autophagy 2021-07-27 Biomarkers

    Abbreviations Aβ: β-amyloid; AD: Alzheimer disease; AIF1/IBA1: allograft inflammatory factor 1; ALP: autophagy-lysosomal pathway; APP: amyloid beta precursor protein; ATP6V1B1/V-ATPase V1b1: ATPase H+ transporting V1 subunit B1; AVs: autophagy vacuoles; BAF: bafilomycin A 1 ; CFC: contextual/cued fear conditioning assay; CHX: Ca 2+ /H + exchanger; CTF-β: carboxy-terminal fragment derived from β-secretase; CTSD: cathepsin D; fAD: familial Alzheimer disease; GFAP: glial fibrillary acidic protein; LAMP1: lysosomal associated membrane protein 1; LTP: long-term potentiation; MCOLN1/TRPML1: mucolipin 1; MAP1LC3B/LC3B: microtubule associated protein 1 light chain 3 beta; MAPT: microtubule associated protein tau; MWM: Morris water maze; NFT: neurofibrillary tangles; PFC: prefrontal cortex; PSEN1: presenilin 1; SQSTM1/p62: sequestosome 1; TBS: theta burst stimulation; TEM: transmission electronic microscopy; TPCN2/TPC2: two pore segment channel 2; WT: wild-type; V-ATPase: vacuolar type H + -ATPase.

  37. Tau oligomer induced HMGB1 release contributes to cellular senescence and neuropathology linked to Alzheimer's disease and frontotemporal dementia

    ✓ Peer-reviewed alzhub usefulness score 49 out of 100. Cell reports 2021-07-01 Inflammation and the immune system

    Aging, pathological tau oligomers (TauO), and chronic inflammation in the brain play a central role in tauopathies, including Alzheimer's disease (AD) and frontotemporal dementia (FTD).

  38. Histological and imunohistochemical alterations of hippocampus and prefrontal cortex in a rat model of Alzheimer like-disease with a preferential role of the flavonoid "hesperidin"

    ✓ Peer-reviewed alzhub usefulness score 37 out of 100. Journal of molecular histology 2021-06-25 Biomarkers

    Alzheimer's disease (AD) is a chronic age-related neurodegenerative disease characterized by degeneration of the central cholinergic neurons, inflammation and oxidative stress in the basal forebrain, prefrontal cortex and hippocampus.

  39. COVID-19 and RA share an SPP1 myeloid pathway that drives PD-L1+ neutrophils and CD14+ monocytes

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. JCI insight 2021-06-18 TREM2 and immune genetics

    We explored the potential link between chronic inflammatory arthritis and COVID-19 pathogenic and resolving macrophage pathways and their role in COVID-19 pathogenesis.

  40. Infiltration by CXCL10 Secreting Macrophages Is Associated With Antitumor Immunity and Response to Therapy in Ovarian Cancer Subtypes

    ✓ Peer-reviewed alzhub usefulness score 51 out of 100. Frontiers in immunology 2021-06-18 TREM2 and immune genetics

    Ovarian carcinomas (OCs) are poorly immunogenic and immune checkpoint inhibitors (ICIs) have offered a modest benefit.

  41. C9orf72 deficiency promotes microglial-mediated synaptic loss in aging and amyloid accumulation

    ✓ Peer-reviewed alzhub usefulness score 40 out of 100. Neuron 2021-06-15 Disease mechanisms

    C9orf72 repeat expansions cause inherited amyotrophic lateral sclerosis (ALS)/frontotemporal dementia (FTD) and result in both loss of C9orf72 protein expression and production of potentially toxic RNA and dipeptide repeat proteins.

  42. G-protein coupled receptor, PI3K and Rho signaling pathways regulate the cascades of Tau and amyloid-β in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 41 out of 100. Molecular biomedicine 2021-06-10 TREM2 and immune genetics

    Alzheimer's disease is a progressive neurodegenerative disease characterized by the presence of amyloid-β plaques in the extracellular environment and aggregates of Tau protein that forms neurofibrillary tangles (NFTs) in neuronal cells.

  43. Ubiquitination of G3BP1 mediates stress granule disassembly in a context-specific manner

    ✓ Peer-reviewed alzhub usefulness score 55 out of 100. Science (New York, N.Y.) 2021-06-01 Lewy body dementia

    Stress granules are dynamic, reversible condensates composed of RNA and protein that assemble in eukaryotic cells in response to a variety of stressors and are normally disassembled after stress is removed.

  44. Dimethyl fumarate abridged tauo-/amyloidopathy in a D-Galactose/ovariectomy-induced Alzheimer's-like disease: Modulation of AMPK/SIRT-1, AKT/CREB/BDNF, AKT/GSK-3β, adiponectin/Adipo1R, and NF-κB/IL-1β/ROS trajectories

    ✓ Peer-reviewed alzhub usefulness score 39 out of 100. Neurochemistry international 2021-05-28 Biomarkers

    Since the role of estrogen in postmenauposal-associated dementia is still debatable, this issue urges the search for other medications.

  45. Meningeal lymphatics affect microglia responses and anti-Aβ immunotherapy

    ✓ Peer-reviewed alzhub usefulness score 61 out of 100. Nature 2021-04-28 Inflammation and the immune system

    Alzheimer's disease (AD) is the most prevalent cause of dementia 1 .

  46. Blocking microglial activation of reactive astrocytes is neuroprotective in models of Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 50 out of 100. Acta neuropathologica communications 2021-04-26 Inflammation and the immune system

    Alzheimer's disease (AD) is the most common cause of age-related dementia.

  47. Supplementation with ribonucleotide-based ingredient (Ribodiet®) lessens oxidative stress, brain inflammation, and amyloid pathology in a murine model of Alzheimer

    ✓ Peer-reviewed alzhub usefulness score 36 out of 100. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021-04-10 Biomarkers

    Alzheimer's disease (AD) is the most common type of dementia worldwide, characterized by the deposition of neurofibrillary tangles and amyloid-β (Aβ) peptides in the brain.

  48. Pancreatic cancer is marked by complement-high blood monocytes and tumor-associated macrophages

    ✓ Peer-reviewed alzhub usefulness score 47 out of 100. Life science alliance 2021-03-29 TREM2 and immune genetics

    Pancreatic ductal adenocarcinoma (PDA) is accompanied by reprogramming of the local microenvironment, but changes at distal sites are poorly understood.

  49. Extracellular signal-regulated kinase regulates microglial immune responses in Alzheimer's disease

    ✓ Peer-reviewed alzhub usefulness score 44 out of 100. Journal of neuroscience research 2021-03-17 TREM2 and immune genetics

    The importance of mitogen-activated protein kinase (MAPK) pathway signaling in regulating microglia-mediated neuroinflammation in Alzheimer's disease (AD) remains unclear.

  50. Triad of TDP43 control in neurodegeneration: autoregulation, localization and aggregation

    ✓ Peer-reviewed alzhub usefulness score 49 out of 100. Nature reviews. Neuroscience 2021-03-02 Brain tissue and pathology

    Cytoplasmic aggregation of TAR DNA-binding protein 43 (TDP43; also known as TARDBP or TDP-43) is a key pathological feature of several neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).

From across this tag

10 of the 1,159 studies in this tag, picked by a fixed rule (a hash of each study's address), not by score or date; each page of this list shows a different 10. The same 10 appear here every time.

All topic tags with their study counts